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<projects><project>
<id>1321</id><title_hr><![CDATA[Metode slabih convergencija i primjene]]></title_hr><title_en><![CDATA[Weak convergence methods and applications]]></title_en><user_id>58</user_id><user_firstLast_name>Nenad Antonić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2013-11</proposal_call><code>IP-2013-11-9780</code><acronim><![CDATA[WeConMApp]]></acronim><duration>01.07.2014 - 30.06.2018</duration><status>Završio</status><financ_value>114.136,16 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Matematika, </scie_field_hr><scie_field_en>Mathematics, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>349, 72, 637, 866, 3374, 86, 1460, 628, 19188, 23449, </team_members_id><team_members_names><![CDATA[Krešimir Burazin, Marko Erceg, Ivan Ivec, Martin Lazar, Nedžad Limić, Marin Mišur, Darko Mitrovic, Marko Vrdoljak, Boris Pawilowski, Ivana Vojnović, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[weak convergences, partial differential equation, homogenisation, optimal design, H-measures, semiclassical measures, transport problems]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Weak convergences are the foundation of most successful methods in the investigation of partial differential equations today. The approach known as Tartar&#39;s programme proved particularly convenient for partial differential equations modelling physical laws; the basic assumption being that weak convergences of sequences of solutions model the transition from microscale to macroscale. Of importance are also mathematical objects being, in a generalised sense, accumulation points of weakly convergent sequences, such as defect measures or H-measures. The research will be directed towards improving the existing weak convergence methods, designing new mathematical objects for that purpose, as well as developing new methods, with particular attention paid to their applications to practical problems.Problems known as homogenisation are tied to properties of mixtures of materials, with important applications in optimal design. Problems related to evolutionary equations and their admissibility conditions mainly concern transport problems in free and porous media, where it is sometimes natural to include continuous time random walk variables in the model. Such problems sometimes also lead to fractional derivative equations. Some problems are related to hyperbolic conservation laws and the propagation and interaction of singularities. High-frequency waves corresponding to solutions of hyperbolic systems are governed by ODEs, allowing for final interpretation as particles. Particularly interesting are situations where the equation changes its type (like transonic fluid flow), motivating our interest in Friedrichs systems. Further results for semilinear systems could open a new approach to the Maxwell-Dirac system, with potential applications in quantum field theory. Practical computation of coefficients in specific applications is also important; as the unknown functions have the domain in multidimensional space, quite often more efficient numerical methods have to be developed.]]></summary_en></project><project>
<id>1326</id><title_hr><![CDATA[Konceptualiziranje nacije i kolektivnih identiteta u Hrvatskoj: Politički rituali i kulturalna memorija trauma 20. stoljeća]]></title_hr><title_en><![CDATA[Framing the Nation and Collective Identity in Croatia: Political Rituals and the Cultural Memory of Twentieth Century Traumas]]></title_en><user_id>2671</user_id><user_firstLast_name>Vjeran Pavlaković</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2013-11</proposal_call><code>IP-2013-11-3782</code><acronim><![CDATA[FRAMNAT]]></acronim><duration>10.06.2014 - 09.06.2018</duration><status>Završio</status><financ_value>68.541,97 eur</financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Povijest, </scie_field_hr><scie_field_en>History, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Filozofski fakultet u Rijeci]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Humanities and Social Sciences]]></institution_en><team_members_id>6622, 4388, 7594, 17786, 7594, </team_members_id><team_members_names><![CDATA[DAVOR PAUKOVIĆ, Benedikt Perak, Tamara Banjeglav, Renato Stanković, Tamara Banjeglav, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[Cultural memory, war, discourse analysis, collective identity, media]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Commemorations and other political rituals are key components of a nation’s cultural memory, crucial for the construction and reinforcement of ideological, ethnic, economic, gender, and other identities. FRAMNAT will involve a dynamic team of young scholars and develop innovative methodologies for cultural memory research and cognitive linguistics analysis relevant for Croatia’s academic and policy-making community, as well as a much broader transnational audience. Croatia’s commemorative culture regarding the wars of the 20th century serves as a platform for politicians to operate within the nation-building narratives. Our project will analyze both top-down and bottom-up strategies of framing the nation and collective identities through commemorative practices of World War Two and the Homeland War in Croatia.  These discourses will be analyzed at three levels: top-down political discourse (elites), media representation and transmission, and the reception of the narratives in Croatian society (bottom-up reactions). Seven commemorations related to World War 2 and the Homeland War will be observed and analyzed using corpus-based linguistic analysis and frame analysis. The media representations of the commemorative events and opinion poll data will likewise be analyzed in order to map how these discourses are transmitted and received in Croatian society. The project results will be disseminated via a regularly updated website (which includes a database of the collected research materials), journal articles, an edited volume, and papers presented at international conferences. Students and other members of the scholarly community will be encouraged to participate in the project through a variety of workshops to be held at the University of Rijeka. The long-term goal is to develop a Cultural Memory Research Center with scientific methods which can be applied to other regional and international case studies.    ]]></summary_en></project><project>
<id>1327</id><title_hr><![CDATA[Pravni aspekti korporativnih akvizicija i restrukturiranje trgovačkih društava utemeljeno na znanju ]]></title_hr><title_en><![CDATA[Legal Aspects of Corporate Acquisitions and Knowledge Driven Companies&#39; Restructuring]]></title_en><user_id>345</user_id><user_firstLast_name>Edita Čulinović-Herc</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2013-11</proposal_call><code>IP-2013-11-9366</code><acronim><![CDATA[LACAKDCR]]></acronim><duration>01.02.2015 - 31.01.2019</duration><status>Završio</status><financ_value>78.145,60 eur</financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Pravo, </scie_field_hr><scie_field_en>Law, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Pravni fakultet]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Law]]></institution_en><team_members_id>3403, 3741, 618, 2793, 3020, 3047, 2685, 626, 4067, </team_members_id><team_members_names><![CDATA[Nataša Žunić Kovačević, Dionis Jurić, Ivana Kunda, Vlatka Butorac Malnar, Antonija Zubović, Mihaela Braut Filipović, Stjepan Gadžo, Danijela Vrbljanac, Nikolina Grković, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[corporate acquisitions, mergers, takeovers, concentrations, taxation of corporate acquisitions,  knowledge based restructuring ]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[In the EU post-accession era, Croatian companies are facing the challenges of corporate acquisitions and restructurings. The latter is an inevitable result of new EU competitors entering the Croatian market. Cross-border and/or domestic corporate regrouping may take different forms depending on the chosen legal model. While being multi-layered phenomena, corporate acquisitions and restructurings are covered by several specialized legal disciplines which the contemporary legal doctrine does not observe as a whole. The aim of this research is to combine the various legal aspects of corporate acquisitions focusing on knowledge driven companies’ restructuring as the most beneficial model. Accordingly, the proposed research will analyze legal models of corporate acquisitions, financing techniques, taxation issues, intellectual property and related competition law concerns, covering thus the topic from the point of company law, capital market law, tax law, competition law and intellectual property law. The research will combine the legislative, judicial and theoretical analysis with the relevant empirical analysis. Cross-referenced results in the respective fields and their systemization will enable the creation of scientifically founded and empirically tested legislative proposals in one single-package. The aim is to enhance the level of protection of all interested parties of corporate acquisitions and knowledge driven restructurings either via strengthening ex ante and/ or ex post control. The results will be disseminated to the legislator, regulators, judiciary and companies as ultimate beneficiaries. What more, project results will enable companies to optimize their choices of restructuring and their position on the market. The dissemination of the project results will ultimately promote and develop knowledge driven restructuring that should in turn increase the competitiveness of the Croatian companies and stimulate the overall economic growth. ]]></summary_en></project><project>
<id>1329</id><title_hr><![CDATA[Fizika Standardnog modela i njena proširenja]]></title_hr><title_en><![CDATA[Physics of the Standard Model and Beyond]]></title_en><user_id>2665</user_id><user_firstLast_name>Blazenka Melic</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2013-11</proposal_call><code>IP-2013-11-5169</code><acronim><![CDATA[PhySMaB]]></acronim><duration>01.10.2014 - 30.09.2018</duration><status>Završio</status><financ_value>96.064,69 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, </scie_field_hr><scie_field_en>Physics, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>5180, 4709, 5888, 17814, 21412, </team_members_id><team_members_names><![CDATA[Goran Duplančić, Fabrizio Nesti, Kornelija Passek-Kumerički, Goran Popara, Domagoj Leljak, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[theoretical particle physics,  Standard Model, perturbative calculations, physics beyond Standard Model, neutrinos]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[In high energy particle physics it is widely believed that the energy frontier experiments at LHC and the planned linear colliders, ILC and/or CLIC, together with ongoing and new experiments in neutrino and flavour physics will unravel fundamental problems in particle and astroparticle physics. A prerequisite for this progress is the complete understanding of the Standard model (SM) predictions. One of the triumphs of SM physics has been the extent to which QCD successfully describes strong interaction processes observed at colliders. More accurate QCD calculations are nowadays essential in understanding the enormous amount of available high-precision data, particularly since new physics effects are obscured by standard QCD processes. Our focus in that area will be to improve the description of hard exclusive processes by including higher-order contributions and by further developing the corresponding methods for automatic QCD calculations. Furthermore, we plan to do precision studies of top-quark production and decay observables which provide a unique view to the mechanism of electroweak symmetry breaking, important for understanding of particle mass generation. In the top-quark decay the information about its spin polarization imprinted by the production process is preserved, and can be calculated and measured in angular distributions of decay products providing other way to search for deviations from the SM expectations. Regarding new physics, the fact that neutrinos have a mass already requires an extension of the SM and calls for an understanding of the origin of neutrino masses. The seesaw mechanism, included in a theory as the one where left-right symmetry (parity) is restored at accessible LHC energies, stands out as a prominent theoretical candidate, and this theory links the origin of neutrino masses to new interactions at high energies and to the restoration of parity. A phenomenological investigation of these predictions is thus compelling and timely.]]></summary_en></project><project>
<id>1338</id><title_hr><![CDATA[Uloga signalnog puta Wnt u epitelno-mezenhimskoj tranziciji]]></title_hr><title_en><![CDATA[The Role of Wnt signaling in Epithelial to Mesenchymal Transition]]></title_en><user_id>139</user_id><user_firstLast_name>Nives Pećina-Šlaus</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2013-11</proposal_call><code>IP-2013-11-6625</code><acronim><![CDATA[WNT4EMT]]></acronim><duration>01.09.2014 - 31.08.2018</duration><status>Završio</status><financ_value>106.178,25 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb School of Medicine]]></institution_en><team_members_id>2813, 1169, 2587, 441, 354, 445, 1170, 3553, 4751, 4287, 4859, 19002, </team_members_id><team_members_names><![CDATA[Davor Tomas, Tomislav Vladušić, Hrvoje Ivan Pećina, Tamara Nikuševa Martić, Anja Kafka, Ljiljana  Šerman, Reno Hrašćan, vili beroš, Martina Zeljko, Goran Mrak, Denys Neville  WHEATLEY, Anja Bukovac, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[Wnt signaling, EMT, brain tumors, invasion, dishevelled, TCF/LEF]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[In the proposed research project we aim to determine the involvement of Dishevelled and TCF/LEF families of human genes in the process of Epithelial-to-Mesenchymal Transition (EMT) in brain tumors. We believe that the changes of structure and expression of the selected genes correlate with the phenotypic changes of tumor cells. EMT is a process very much involved in invasion and progression of tumors. Many oncogenic signaling pathways can induce EMT. The classical Wnt pathway has a particularly tight link with EMT and it has been shown that nuclear translocation of beta-catenin can induce EMT. Wnt pathway is one of the basic cellular pathways whose misregulation plays important roles in tumorigenesis and whose mediators of transcription are members of TCF/LEF family. Another important protein family is the Dishevelled considered to be the central hub of Wnt signaling since it interacts with Wnt receptors and recruits the multiprotein beta-catenin destruction complex. The experiments of the proposed research will use modern methods of molecular biology for the analyses of brain tumor samples of different malignancy grades. The genetic changes will be tracked by PCR/loss of heterozygosity, heteroduplex and Spreadex electorphoresis (Elchrom Scientific, Switzerland) methods. Expression of selected proteins will be studied by immunohistochemistry demonstrating their location in tumor cells. Besides its scientific value, results from the proposed project will have an application in medical diagnostics. Identifying changes in molecules responsible for control of cell motility will give us the preconditions for understanding the invasiveness of brain tumors and offer new disease progression markers. Our experimental evidence would also encourage the development of therapies that specifically interfere with Wnt signaling in cancer. ]]></summary_en></project><project>
<id>1340</id><title_hr><![CDATA[Algebarske i kombinatorne metode u teoriji verteks algebri]]></title_hr><title_en><![CDATA[Algebraic and combinatorial methods in vertex algebra theory]]></title_en><user_id>92</user_id><user_firstLast_name>Dražen Adamović</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2013-11</proposal_call><code>IP-2013-11-2634</code><acronim><![CDATA[ACMVAT]]></acronim><duration>01.07.2014 - 30.06.2018</duration><status>Završio</status><financ_value>70.677,00 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Matematika, </scie_field_hr><scie_field_en>Mathematics, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>1285, 1098, 746, 1252, 631, 636, 632, 687, 1138, 638, 4027, 17775, </team_members_id><team_members_names><![CDATA[Goran Trupčević, Marijan Polić, Josip Vujčić, Tomislav Šikić, Gordan Radobolja, Slaven Kožić, Ozren Perše, Marijana Butorac, Miroslav Jerković, Mirko Primc, Boris Širola, Ana Kontrec, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[vertex algebras, W-algebras,  affine  Lie algebras, logarithmic  CFT, combinatorial bases,  Zhu&#39;s algebras, C2 cofiniteness,]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[In the proposed project we shall study the representation theory of important classes of vertex algebras with particular emphasis on the theory of vertex algebras with origins  in physics. We shall also study the affine vertex algebras and their connections with W-algebras. Based on previous research of D. Adamović and O. Perše from the papers J. Algebra 319 (2008); SIGMA 8 (2012); Algebras and Representation Theory 16 (2013) we shall apply the representation theory of vertex algebras of affine type   to the structure and representation theory of W-algebras. In the last few years, C2-cofinite, irrational vertex algebras with non-semisimple representation categories attracted a lot of interest. Such vertex algebras also appear in the logarithmic conformal field theory. By using methods developed in the papers by  D. Adamović and  A. Milas: Adv. Math. 217 (2008), Comm. Math. Phys. 288 (2009),  Adv. Math. 227 (2011)  and  J. Math. Phys. 73511 (2012) we shall study the representation theory of certain irrational, C2-cofinite vertex algebras and their connections with the theory of quantum groups. An emphasis will be put on the tensor categories of modules of C2-cofinite vertex algebras, the determination of fusion rules, orbifold vertex subalgebras and the explicit realization of logarithmic representations.  A part of the research will be devoted to some combinatorial aspects of the  representation theory of affine Kac-Moody Lie algebras. We will study  the application of intertwining operators   on the determination of   combinatorial bases of Feigin-Stoyanovsky type subspace and the associated fermionic character formulas developed by M. Primc and  collaborators. We also plan to apply the above methods on the combinatorial structures related to triplet vertex algebras and logarithmic CFT.]]></summary_en></project><project>
<id>1341</id><title_hr><![CDATA[Otvaranje obrazovanja kroz učenje unutar i izvan škola i kolaboraciju na mobilnim tablet računalima]]></title_hr><title_en><![CDATA[Opening up education through Seamless and COLLAborative Mobile learning on tablet computers]]></title_en><user_id>151</user_id><user_firstLast_name>Ivica Botički</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2013-11</proposal_call><code>UIP-2013-11-7908</code><acronim><![CDATA[SCOLLAm]]></acronim><duration>01.09.2014 - 31.08.2017</duration><status>Završio</status><financ_value>102.115,27 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Računarstvo, </scie_field_hr><scie_field_en>Computer sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id>2986, 2994, 3154, 3186, 6008, 3612, </team_members_id><team_members_names><![CDATA[Neven Drljevic, Vedran Mornar, Igor Mekterovic, Natasa Hoic-Bozic, Peter Seow, Tomislav Jagušt, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[seamless learning, mobile learning, technology enhanced learning, collaborative learning, informal learning, educational technology]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[This project explores the potential of using mobile technology for seamless and mobile learning in Croatia and proposes a technologically innovative mobile learning platform named SCOLLAm. Being one of the first scientific mobile learning projects in Croatian schools, it explores both technology and pedagogies through two studies leveraging tablet computers in Croatian classrooms. In the first study, SCOLLAm will be deployed in a primary school to support new seamless and collaborative lessons in and across the existing subjects. In the second study, augmented mobile learning technology and the accompanying digital lessons will be used as a tool to support seamless and collaborative learning in a vocational school. These studies seek to stimulate and explore the effectiveness of mobile learning in Croatian schools in a strictly scientific manner, by engaging in digital mobile lesson co-design with the school teachers. The project will leverage experience from mobile learning research groups from Singapore, Sweden and USA in order to develop a new set of tools and lessons suitable for Croatian educational system. In order to move away from the tools typically targeting one platform and providing only limited adaptation mechanisms with virtually no learning analytics, one of the project objectives is the design, development and deployment of a scalable, adaptive and analytics driven platform SCOLLAm. Through the designed studies, produced open localizable educational resources and the SCOLLAm platform, we expect to see that the participants benefit from the introduction and use of mobile technology and applications through increased learning, collaboration skills and self-directedness, and acquire 21st century skills needed in their further education and life.]]></summary_en></project><project>
<id>1350</id><title_hr><![CDATA[Uvjeti, resursi, neprijatelji i bioraznolikost: Sile koje oblikuju morske zajednice u plitkom Jadranskom moru]]></title_hr><title_en><![CDATA[Conditions, Resources, Enemies, and Biodiversity: Forces structuring marine communities of the shallow Adriatic Sea]]></title_en><user_id>1269</user_id><user_firstLast_name>Stewart Schultz</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2013-11</proposal_call><code>IP-2013-11-3107</code><acronim><![CDATA[COREBIO]]></acronim><duration>01.10.2014 - 30.09.2018</duration><status>Prekinut</status><financ_value>97.694,66 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Biologija, </scie_field_hr><scie_field_en>Biology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zadru]]></institution_hr><institution_en><![CDATA[University of Zadar]]></institution_en><team_members_id>3702, 5004, 4486, 6648, 17825, </team_members_id><team_members_names><![CDATA[Tatjana Bakran-Petricioli, Claudia Kruschel, Donat Petricioli, Alen Soldo, Dubravko Pejdo, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[community ecology, fish, Posidonia, habitat, monitoring]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[This project is an investigation of the major drivers of fish community structure in the shallow Adriatic Sea of Croatia.  This information is crucial for the sustainable, scientific management of coastal ecosystems, as required by EU instruments such as the Habitats Directive, Marine Strategy Framework Directive, Water Framework Directive, and the Common Fisheries Policy.   The major questions asked are 1) What are the ecological baselines in Croatia in community structure?  2) How does anthropogenic activity (harvesting, coastal development) shift community structure from baseline?  3) How do marine protected areas maintain functional communities?  4) How is community structure changing over time?   We will investigate these questions using innovative, non-destructive techniques for quantifying fish abundance and size distribution, and benthic habitat quality.  These techniques include lure-assisted, underwater visual census which was originally developed in the Schultz laboratory; baited, underwater video; and DGPS-assisted, towed underwater video.  EU policies require that non-destructive methods for assessment and monitoring replace destructive harvest-based methods currently in widespread use, and these methods are among the most scientifically supported non-destructive methods currently available.  These methods will be used to quantify fish community structure and benthic habitat at all major MPAs and former MPAs in Croatia, to compare communities within MPAs to matched locations outside MPAs.   Matched locations will be chosen to test for specific anthropogenic drivers of community structure, such as high fishing pressure, coastal development, marine tourism, aquaculture, and terrestrial runoff.  These results will advance our basic understanding of coastal ecosystems, and will be crucial for satisfying Croatia&#39;s responsibilities as an EU citizen in MPA construction, management, and monitoring of marine resources.]]></summary_en></project><project>
<id>1352</id><title_hr><![CDATA[Hrvatska u 20. stoljeću: modernizacija u uvjetima pluralizma i monizma]]></title_hr><title_en><![CDATA[Croatia in the 20th century: modernization in the context of pluralism and monism]]></title_en><user_id>515</user_id><user_firstLast_name>Zdenko Radelić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2013-11</proposal_call><code>IP-2013-11-3481</code><acronim><![CDATA[Croatia20thcentury]]></acronim><duration>01.07.2014 - 30.06.2018</duration><status>Završio</status><financ_value>27.367,44 eur</financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Povijest, </scie_field_hr><scie_field_en>History, </scie_field_en><institution_hr><![CDATA[Hrvatski institut za povijest]]></institution_hr><institution_en><![CDATA[Croatian Institute of History]]></institution_en><team_members_id>1344, 1060, 1350, 1375, 1361, 2545, 1357, 1345, 286, 2834, 2933, </team_members_id><team_members_names><![CDATA[Miroslav Akmadža, Nikica Barić, Davor  Kovačić, Zdravka Jelaska Marijan, Hrvoje Čapo, Josip Kajinić, Josip Mihaljević, Ivana Šubic Kovačević, Marko Zubak, Stipe Kljajić, Mario Jareb, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[Croatia, Kingdom of Yugoslavia, Independent State of Croatia, Socialist Federative Republic of Yugoslavia, democracy, dictatorship, totalitarianism]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[The aim of the project is to research the political, economical, social and cultural developments in Croatia from 1918 when Austro-Hungarian Empire collapsed, to 1991 when socialist Yugoslavia disintegrated. Thus the project covers the period of about 70 years, from 1914/1918 to 1991. The project will cover complete present day Croatian territory as well as neighbouring areas where necessary. The project will include various topic – ideologies and politics, national and religious questions, as well as culture, especially the role of media and sport in the social life. Research will cover a wide range of events and historical processes: formation and spreading of national and political ideas and their realization through the activities of political parties and movements; organization of state security and police; reconstruction of everyday life; the question of identity of various groups of Croatian society. The project will also cover the biographies of certain persons and how certain regimes treated them. More specifically the project will research the consequences of World War I on the population; the activities of state authorities of Kingdom of Serbs, Croats and Slovenes/Yugoslavia, Independent State of Croatia, Federal People&#39;s Republic of Yugoslavia/Socialist Federative Republic of Yugoslavia and to the present day Republic of Croatia. The research will concentrate on the question of freedom of nations and individuals and the influence of external political forces.]]></summary_en></project><project>
<id>1358</id><title_hr><![CDATA[Računalna rješenja u bioznanostima: Značaj savitljivosti molekula]]></title_hr><title_en><![CDATA[Computational Solutions in the Life Sciences: The Importance of Molecular Flexibility]]></title_en><user_id>326</user_id><user_firstLast_name>David Smith</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2013-11</proposal_call><code>IP-2013-11-8238</code><acronim><![CDATA[CompSoLS-MolFlex]]></acronim><duration>15.07.2014 - 14.12.2018</duration><status>Završio</status><financ_value>119.450,53 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, </scie_field_hr><scie_field_en>Chemistry, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>2848, 854, 56, 3235, 2682, 3093, 2666, 2736, 3618, 5501, 18936, </team_members_id><team_members_names><![CDATA[Nadja Doslic, Darko Babić, Borislav Kovačević, Danijela  Barić, Ana-Sunčana Smith, Karmen Čondić-Jurkić, Momir Mališ, Jurica Novak, Zlatko Brkljača, Ivan DRAGIČEVIĆ, Marko Hanževački, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[Molecular Flexibility, Computational Chemistry, Peptides, Proteins, Enzyme Catalysis]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Molecular flexibility controls a number of key processes ranging from protein folding to the design of advanced materials. However, the detailed understanding of its impact on a given process is poorly understood. Direct investigation of this phenomenon by experimental means, is a challenging endeavour, as the microscopic details are frequently hidden from macroscopic observations. Computational simulations, on the other hand, provide detailed information regarding molecular dynamics and flexibility. The theoretical approach is thus crucial in both understanding the experimental results and in expanding the underlying conceptual framework.The present project proposes to utilize state-of-the-art computational techniques to address the importance of molecular flexibility across a range of carefully selected examples from the life sciences. The examples, which can be classified under the headings: (i) peptides and spectroscopy, (ii) protein flexibility, and (iii) enzyme related transformations, have been chosen to span multiple time and length scales and thus to highlight the diverse and wide-reaching nature of molecular flexibility. The selected examples exhibit a significant degree complementarity and synergy with one another and are all associated with their own applicative importance in different areas of (bio)chemistry.In addition to the scientific research proposed, the project aims to consolidate a highly successful and competitive platform in computational life sciences that has been established at the RBI. This platform was already recognized through the granting of an EU-FP6 project (2007-2010). The current project team is thus well equipped for the proposed work and exhibits a good balance between senior researchers, with excellent track records, and junior scientists with outstanding potential. The support of the project team by HrZZ is crucial for maintaining their competitiveness in the international scientific environment of computational life sciences.]]></summary_en></project><project>
<id>1366</id><title_hr><![CDATA[SINTEZA I CITOSTATSKA ISPITIVANJA  BIBLIOTEKE NOVIH DUŠIKOVIH HETEROCIKLA]]></title_hr><title_en><![CDATA[SYNTHESIS AND CYTOSTATIC EVALUATIONS OF NOVEL NITROGEN HETEROCYCLES LIBRARY]]></title_en><user_id>76</user_id><user_firstLast_name>Silvana Raić-Malić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2013-11</proposal_call><code>IP-2013-11-5596</code><acronim><![CDATA[SCIENcENTRY]]></acronim><duration>02.06.2014 - 31.05.2018</duration><status>Završio</status><financ_value>123.967,88 eur</financ_value><scie_area_hr>Prirodne znanosti, Biomedicina i zdravstvo, </scie_area_hr><scie_area_en>Natural sciences, Biomedicine and health sciences, </scie_area_en><scie_field_hr>Kemija, </scie_field_hr><scie_field_en>Chemistry, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet kemijskog inženjerstva i tehnologije]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Chemical Engineering and Technology]]></institution_en><team_members_id>3924, 2914, 2865, 2847, 2768, 2769, 1135, 3913, 1219, 2835, 2767, 3261, 2811, 17839, </team_members_id><team_members_names><![CDATA[Tatjana Gazivoda Kraljević, Marijana Hranjec, Livio Racané, Irena Sović, Maja Aleksić, Nataša Perin, Andrijana Meščić, Silvija Maračić, Maja Stipković Babić, Višnja Stepanić, Krešimir Pavelić, Mirela Sedić, Grace Karminski-Zamola, Andrea Bistrović, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[1,2,3-triazole-heterocycles hybrids, benzimidazoles, benzothiazoles, synthesis, cytostatic activity, in silico and docking analysis, DNA binding]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Cancer is one of the most serious health problems of a worldwide dimension. One in three of the population develops cancer at some time in their lives and one in four dies from this disease. The main problems in antitumor chemotherapy are drug resistance and side effects on normal tissues. In the recent years a tremendous growth was witnessed in synthesis and development of vast number and types of new heterocyclic antitumor agents, with an emphasis on creation of new drugs with better selectivity or activity. The latter are indeed major requirements in development of novel anticancer drugs. The proposed scientific project is highly interdisciplinary and objective-oriented with the principal aim to develop the novel lead compounds with pronounced and selective anticancer activity that would be used for further phases of drug development.To achieve the principal aim following specific tasks are foreseen. The goal of the first one is to synthesize small-compound library (Classes A–H) comprising new conjugates of pseudopurines, coumarines and quinolines with 1,2,3-triazole scaffold, N-acyclic 5-unsaturated pyrimidine derivatives, amino-, amido- and amidino substituted benzimidazole, benzothiazole and benzo[b]thieno-2-carboxamide derivatives. Molecule library will be synthesized using modern synthetic approaches such as click chemistry, palladium mediated cross-coupling, eco-friendly microwave assisted and photochemical reactions as well as classical organic synthetic methods. The aim of the second task is to predict plausible biological targets and pharmacological activities using cheminformatics/in silico analysis. The third task is to perform cytostatic evaluations based on which hit molecules with desired biological effect will be selected for structure optimization that will be subsequently carried out. Finally, the molecular mechanism studies are anticipated for the most effective compounds from synthesized N-heterocycles library.]]></summary_en></project><project>
<id>1367</id><title_hr><![CDATA[Periodički npregnuti grfen; strukturna i elektroska svojstva]]></title_hr><title_en><![CDATA[Periodically strained graphene; structural and electronic properties]]></title_en><user_id>105</user_id><user_firstLast_name>Petar Pervan</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2013-11</proposal_call><code>IP-2013-11-2727</code><acronim><![CDATA[PerStaGra]]></acronim><duration>01.07.2014 - 31.08.2016</duration><status>Prekinut</status><financ_value>46.851,15 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, </scie_field_hr><scie_field_en>Physics, </scie_field_en><institution_hr><![CDATA[Institut za fiziku]]></institution_hr><institution_en><![CDATA[Institute of Physics in Zagreb]]></institution_en><team_members_id>3486, 3090, 3104, 6373, 6283, </team_members_id><team_members_names><![CDATA[Vesna Mikšić Trontl, Iva Šrut Rakić, Ivo Pletikosić , Tonica Valla, Asensio Maria Carmen, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[graphene, strain, vicinal surface, fermi velocity, spin-orbit coupling, STM, ARPES]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[A strained graphene offers a valuable avenue for the manipulation in altering its electronic structure. Graphene can withstand rather large elastic deformation and it appears that within the elastic response there is a range of different modifications in graphene’s electronic structure. This is a basis of what is called “strain engineering”. Recent theoretical calculations suggest that uniaxial strain or shear deformations can induce opening of the electron band gap, anisotropic modification of the Fermi velocity, spin-orbit interaction  and consequently alter the transport properties. However, there is still no consensus on the mechanical conditions required to obtain a particular electronic modification. In this project we propose a systematic study of structural and electronic properties of periodically rippled graphene. We have already demonstrated that graphene conforms to the stepped (vicinal) iridium surface – Ir(332) creating periodic structure at nanometer scale. It is aim of this project to experimentally explore the dependence of the electronic structure of graphene with respect to periodicity of the graphene corrugation, orientation of the graphene with respect to the shear deformation (zig-zag with respect to armchair direction). By intercalation of different elements we will alter the graphene substrate interaction with the aim to control the structure of the underlying surface and consequently valence band structure of graphene. We shall investigate structural properties of graphene on Ir(332) by Scanning Tunneling Microscope (STM) and Atomic Force Microscope (AFM). The focus in the investigation of electronic properties will be on the ARPES study of anisotropic distortion of the Dirac cone, relation with the direction of the graphene modulation, spin-orbit interaction and on the possibility to induce electron band gap. ]]></summary_en></project><project>
<id>1371</id><title_hr><![CDATA[Procjena i predviđanje produktivnosti šumskog ekosustava objedinjavanjem terenskih izmjera, daljinskih istraživanja i modeliranja]]></title_hr><title_en><![CDATA[Estimating and Forecasting Forest Ecosystem Productivity by Integrating Field Measurements, Remote Sensing and Modelling]]></title_en><user_id>360</user_id><user_firstLast_name>Hrvoje Marjanović</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2013-11</proposal_call><code>UIP-2013-11-2492</code><acronim><![CDATA[EFFEctivity]]></acronim><duration>01.07.2014 - 30.06.2017</duration><status>Završio</status><financ_value>80.084,94 eur</financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Šumarstvo, </scie_field_hr><scie_field_en>Forestry, </scie_field_en><institution_hr><![CDATA[Hrvatski šumarski institut]]></institution_hr><institution_en><![CDATA[Croatian Forest Research Institute]]></institution_en><team_members_id>819, 1275, 843, 6352, 7033, 18937, 17816, </team_members_id><team_members_names><![CDATA[Maša Zorana Ostrogović, Ivan  Balenović, Elvis Paladinić, Krunoslav Indir, Zoltan Barcza, Anikó Kern, Mislav Anić, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[forest productivity, Quercus robur, GPP, NPP, eddy covariance, MODIS, Biome-BGC, photogrammetry, dendrometers, soil respiration]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Forest play important role in climate regulation and secure resources vital for local economy,  but the imminent climate change will affect their productivity, and for some tree species possibly even their sustainability. Thus, monitoring forest productivity and understanding effects of key environmental drivers becomes essential for forest management. This is a challenging task, particularly due to great costs related to it. Hereby we propose a research, aimed at addressing this issue, with a novel approach that could facilitate fast and cost-effective assessments of forest productivity. The research would be conducted on pedunculate oak forests (Quercus robur L.) which are economically, and ecologically, one of the most important in Croatia.  Main objective of the proposed research is to develop and test methods and workflows for the estimation of annual productivity of forests at the local scale by using existing research infrastructure for measurement of carbon fluxes (EC monitoring system), freely available high temporal resolution data from remote sensing (MODIS) and state of the art process model (Biome-BGC). The proposed research will provide the first evaluation on the quality of MODIS GPP and NPP estimates for Central-European lowland forests. Field measurement campaigns combined with state of the art digital photogrammetry will be performed to parameterise Biome-BGC model, and validate data from MODIS and model simulations. Using available data on future climate scenarion, productivity of oak forests for the future 30-50 years will be simulated with Biome-BGC model.   The proposed research is in line with the objectives of the EU Forest Action Plan which, among others proposes to encourage adaptation to the effects of climate change (key action 6), and to work toward a European Forest Monitoring System (key action 8).]]></summary_en></project><project>
<id>1381</id><title_hr><![CDATA[PRIMJENA PLAZME STVORENE VISOKONAPONSKIM ELEKTRIČNIM PRAŽNJENJEM  PRI KONZERVIRANJU TEKUĆE HRANE ]]></title_hr><title_en><![CDATA[APPLICATION OF ELECTRICAL DISCHARGE PLASMA FOR PRESERVATION OF LIQUID FOODS]]></title_en><user_id>206</user_id><user_firstLast_name>Zoran Herceg</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2013-11</proposal_call><code>IP-2013-11-6248</code><acronim><![CDATA[NTP01]]></acronim><duration>15.09.2014 - 14.09.2018</duration><status>Završio</status><financ_value>112.814,39 eur</financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Prehrambena tehnologija, </scie_field_hr><scie_field_en>Food technology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prehrambeno-biotehnološki fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Food Technology and Biotechnology]]></institution_en><team_members_id>526, 1307, 453, 448, 707, 493, 591, 590, 1002, 2653, 3170, 2917, 2609, 4033, </team_members_id><team_members_names><![CDATA[Selma Mededovic Thagard, Damir Stanzer, Jasna Mrvčić, Suzana Rimac Brnčić, Hrvoje Juretić, Tomislava  Vukušić, Marija  Badanjak Sabolović, Višnja Stulić, Ivona Elez Garofulić, Stela Križanović, Mara Banović, Ivančica Delaš, Zlatko Kregar, Vlasta Horvatić, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[Electrical discharge plasma, liquid-phase plasma reactor, liquid food, physico-chemical properties, nutritional and sensory properties]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[With the growing knowledge of the importance of food in maintaining the human health, the food industry is faced with increasing challenges to develop new non-thermal food treatment technologies that would prevent and mitigate food contamination while retaining nutritional and functional properties of the treated food. Electrical discharge plasma is one of these more promising techniques. Plasmas formed directly in liquid inactivate microorganisms and without significant increase in temperature during the treatment. However, knowledge gaps regarding the nature of sterilization, inactivation mechanism and the plasma reactor design have been identified as major constraints for the applicability of this technology in food industry. Thus the main goal of the proposed project is to design and develop a non-thermal plasma reactor for the treatment of fruit juices and milk and optimize it to maximize the utilization of UV light and chemical species produced by plasma.  To achieve this goal, we propose to address the following research objectives (R):R1     Develop and optimize a liquid-phase plasma reactor for treatment of fruit juices and milk.R2       Characterize the chemical and electrical properties of the liquid plasmas. R3  Evaluate the ability of the liquid-phase plasma to inactivate pathogenic microorganisms in suspensions of pure culture microorganisms and suspended in fruit juices and milk respectively. R4       Determine inactivation mechanism of the plasma treatments on microorganisms R5      Determine the effect of the plasma treatments on the physico-chemical, nutritional and sensory properties of juices and milk.The significance of the proposed research lies in the development of a novel plasma reactor as well as acquires new knowledge regarding the science behind the forthcoming plasma technology which can then be applied towards introducing and potentially replacing current processing technologies with plasma.]]></summary_en></project><project>
<id>1382</id><title_hr><![CDATA[Uloga receptora autofagije u selektivnom uklanjanju mitohondrija]]></title_hr><title_en><![CDATA[The role of autophagy receptors in selective removal of mitochondria]]></title_en><user_id>62</user_id><user_firstLast_name>Ivana Novak Nakir</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2013-11</proposal_call><code>UIP-2013-11-5246</code><acronim><![CDATA[AutoMito]]></acronim><duration>01.03.2015 - 30.09.2018</duration><status>Završio</status><financ_value>132.722,81 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Splitu, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Split School of Medicine]]></institution_en><team_members_id>3657, 6096, 17855, </team_members_id><team_members_names><![CDATA[Brady Nathan, Ivan Đikić, Mija Marinković, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[autophagy, mitochondria, mitophagy, receptor, neurodegeneration, cancer]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Autophagy is cellular degradation pathway essential for cell survival, development and differentiation. Its digestive property has been shown important in different pathologies including cancer, neurodegeneration and pathogen removal. Discoveries of specific autophagy receptors have opened a new chapter in the autophagy field. Of great interest is the removal of damaged or excess mitochondria through specialized autophagy- mitophagy. Together with colleagues, I have identified and characterized mitochondrial proteins Nix/Bnip3L and Bnip3 as a mitophagy receptors for recruiting the autophagic machinery to damaged mitochondria and help their elimination (Novak et al, 2010; Zhu et al, 2013). We demonstrated that receptors mediate mitochondrial clearance during reticulocyte differentiation. Our goal is to further study autophagy receptors and proteins associated with mitochondrial clearance to better understand the role of mitophagy and its mechanism. We will study: (1) phosphorylation and dimerization of receptors and the consequences of this events on mitophagy progression; (2)factors that regulate tight connection of apoptosis and mitophagy; (3)potential interplay between mitophagy receptors and other mitophagy-related proteins, like  E3-ligase Parkin and kinase PINK1; (4)the effects of mitophagy on cancer development. To reach our goals we will use established methodology in our laboratories including protein identification and interaction techniques (Western blot, IP, GST-pull down, RNAi), immunofluorescent microscopy, mass spectrometry, ITC and NMR. All experiments will be performed using cultured cells. This project proposal has a high capacity to generate very interesting data with high possibility for publications in top scientific journals. Fundamentally, generated data will help to understand the physiological and pathological conditions, such as neurodegeneration and cancer and allow us to manipulate mitophagy to fight diseases.]]></summary_en></project><project>
<id>1386</id><title_hr><![CDATA[Notch u diferencijaciji hematopoetskih stanica matica i u razvoju leukemija]]></title_hr><title_en><![CDATA[Notch in hematopoietic stem cell differentiation and leukaemia development ]]></title_en><user_id>498</user_id><user_firstLast_name>Mariastefania Antica</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2013-11</proposal_call><code>IP-2013-11-7140</code><acronim><![CDATA[NOBLE]]></acronim><duration>10.09.2014 - 09.02.2019</duration><status>Završio</status><financ_value>116.132,46 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>3776, 3576, 559, 3672, 6232, 17773, </team_members_id><team_members_names><![CDATA[Ivan Bilić, Maja Matulić, Isidoro Feliciello, Li Wu, Mladen Paradzik, Luka Horvat, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[ hematopoietic stem cells, leukemia, Notch, Ikaros, non-coding RNA,differentiation, ]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[The relevance of adult (somatic) stem cell research is increasing steeply with a growing number of human diseases shown to be curable by stem cell therapy. The present study plan aims the research towards the gene regulatory mechanisms that control hematopoietic stem cell (HSCs) homeostasis and differentiation, which is tightly regulated by an interplay of a number of transcription factors and environmental signals mediated by a Notch signaling pathway. Our group designed an experimental approach for studying the interaction of Notch signaling pathway with transcription factor genes associated with hematopoiesis with focus on Ikaros gene family. Our laboratory has established a diagnostic technique for quick and sensitive detection of aberrant Notch and Ikaros forms by single cell multiplex qRT-PCR, which is a unique tool enabling us to dissect the contribution of different members of the Ikaros and Notch families on differentiation and survival of hematopoietic cells in a context of regulation of expression of target genes as well as non-coding RNAs, since they maintain the spatial organization of chromosome structure and regulate cell commitment. Our results will improve diagnosis and risk stratification for leukaemia patients which will be an important aid in informed clinical decisions. Therefore the proposed project will substantially advance the field towards better therapeutic options and contribute significantly to the field of stem cell medicine. ]]></summary_en></project><project>
<id>1387</id><title_hr><![CDATA[Bioindikatori vodenih masa u Jadranu]]></title_hr><title_en><![CDATA[Bio-tracing Adriatic water masses (BIOTA)]]></title_en><user_id>2829</user_id><user_firstLast_name>Zrinka Ljubešić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2013-11</proposal_call><code>UIP-2013-11-6433</code><acronim><![CDATA[BIOTA]]></acronim><duration>01.10.2014 - 30.09.2017</duration><status>Završio</status><financ_value>124.597,26 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Biologija, </scie_field_hr><scie_field_en>Biology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>2843, 4351, 4337, 451, 1519, 17842, 1305, </team_members_id><team_members_names><![CDATA[Damir Viličić, Petar Kružić, Sunčica Bosak, Jelena Godrijan, Marijana Miloslavić, Maja Mejdandžić, Ivana Bosnjak, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[Adriatic Sea, climate changes, water mass tracers, cyanobacteria, coccolithophorids]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Interannual changes in the circulation patterns and water mass dynamics highly influence biogeochemical processes in the Adriatic Sea, consequently impacting the functioning of the Adriatic ecosystem. Specific phytoplankton ecological preferences drive their temporal and spatial distribution, reflecting their dependence on specific temperature ranges, light levels, nutrient availability and other environmental gradients. Hence, some phytoplankton taxa can be used as water mass tracers (biotracers). We hypothesize that picophytoplanktonic prokaryote Prochlorococcus and nanophytoplanktonic eukaryotes coccolithophores: Emiliania huxleyi and/or Gephyrocapsa oceanic are such organisms, and can be used for tracing water masses in the Adriatic. Here, we propose interdisciplinary study where oceanography, taxonomy of phytoplankton and molecular recognition are combined to detect and follow water masses. Two winter cruises in the southern Adriatic will be conducted with station positions and sampling depths defined in situ. Water mass detection will be based on pre-defined physical characteristics; however, we also plan to use optical measurements in conjunction with the proposed sampling to develop an optical based criterion for definition of the targeted water masses. Phytoplankton community will be assessed using multiple tools to confirm the presence and to determine distribution, abundance and diversity of the proposed biotracers in sampled water masses. With the variability and trends of the Adriatic circulation as well as the water mass characteristics brought on by changing climate, we believe that proposed study is timely and needed as it is offering a holistic and integrated approach to oceanography of the Adriatic. Most importantly, this study is proposing to develop a new set of interdisciplinary tools that will be essential for future research activities.]]></summary_en></project><project>
<id>1400</id><title_hr><![CDATA[Dijagnostika Interakcije lasera i hladne plazme]]></title_hr><title_en><![CDATA[Laser - Cold Plasma Interaction and Diagnostics]]></title_en><user_id>140</user_id><user_firstLast_name>Slobodan Milošević</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2013-11</proposal_call><code>IP-2013-11-2753</code><acronim><![CDATA[LaCPID]]></acronim><duration>01.06.2014 - 31.05.2018</duration><status>Završio</status><financ_value>112.984,74 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, </scie_field_hr><scie_field_en>Physics, </scie_field_en><institution_hr><![CDATA[Institut za fiziku]]></institution_hr><institution_en><![CDATA[Institute of Physics in Zagreb]]></institution_en><team_members_id>2611, 2867, 1500, 3306, 4041, 4033, 1271, 17797, </team_members_id><team_members_names><![CDATA[Marijan Bišćan, Robert Beuc, Damir Veža, Mladen Movre, Čedomil Vadla, Vlasta Horvatić, Nikša Krstulović, Dean Popović, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[low temperature plasmas, laser produced plasmas, cold plasmas, atmospherics plasmas, laser spectroscopy]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Cold and low-density plasmas are currently in focus of basic research worldwide due to many open questions regarding their complex nature and simultaneously due to their high potential for applications in various fields of research and technology. Plasmas can be produced by bombarding matter either with energetic electrons or with energetic photons. The first kind is related to use of various discharges and the second to use of powerful lasers. Our interest is in plasmas produced in vacuum, under low-pressure gas environment, at atmospheric air or on/within liquids. Discharges which we use range from electrodeless, single electrode to various designs of two electrode systems. Lasers we use are cw or pulsed nanosecond.  In our research special care will be devoted to tailoring the electron energy distribution functions as a key factor influencing plasma content and features. This is usually done by changing macroscopic plasma parameters - gas pressure, electrical fields and geometry of discharges. In this project we shall combine laser produced plasmas with discharge plasmas to achieve that goal. To understand the complex nature of plasma or processes of plasma interaction with other matter phases (gases, liquids and solids) basic approach is to perform plasma diagnostics by various types of optical and laser spectroscopies. To interpret findings we study basic atomic collision processes in plasmas and structure and spectra of various complexes formed within plasma (dimers, radicals etc). Modeling of various processes within cold plasmas and laser produced plasmas is performed in addition. In various applications in which plasma treatment of matter is used there is a need for in situ monitoring of processes both in plasma and at interfaces and therefore both spatial and temporal spectral resolution of applied detection techniques are important. We use classical emission and absorption laser spectroscopies and modern techniques such as a cavity ring-down spectroscopy.]]></summary_en></project><project>
<id>1402</id><title_hr><![CDATA[Utjecaj endemskog ratovanja na zdravlje kasnosrednjovjekovnih i ranonovovjekovnih populacija Hrvatske]]></title_hr><title_en><![CDATA[The effects of endemic warfare on the health of historic period populations from Croatia]]></title_en><user_id>2788</user_id><user_firstLast_name>Mario Šlaus</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2013-11</proposal_call><code>IP-2013-11-8100</code><acronim><![CDATA[Warandhealth]]></acronim><duration>30.06.2014 - 29.06.2018</duration><status>Završio</status><financ_value>79.615,20 eur</financ_value><scie_area_hr>Humanističke znanosti, Biomedicina i zdravstvo, Prirodne znanosti, </scie_area_hr><scie_area_en>Humanities, Biomedicine and health sciences, Natural sciences, </scie_area_en><scie_field_hr>Etnologija i antropologija, </scie_field_hr><scie_field_en>Ethnology and anthropology, </scie_field_en><institution_hr><![CDATA[Hrvatska akademija znanosti i umjetnosti]]></institution_hr><institution_en><![CDATA[Croatian Academy of Sciences and Arts]]></institution_en><team_members_id>2670, 567, 596, 2583, 2919, 3780, 1439, 19012, </team_members_id><team_members_names><![CDATA[Mario Novak, Željka Bedić, Vlasta Vyroubal, Marin Vodanović, Emma Lightfoot, Hrvoje Brkić, Mislav Čavka, Anita Adamić, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[physical anthropology, bioarchaeology, paleopathology, health, war, osteological analyses, medieval period, Croatia]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Warfare has afflicted humankind throughout its history, and is a phenomenon that still fundamentally affects the modern world. Despite the fact that violence -related mortality is profoundly undercounted, violent conflict represents the third most important source of mortality around the world. Analyzing the effects that war had on health through the deep time perspective that archaeological investigations afford can provide unique data on the interactions between warfare, health and the environment and provided conclusions that are particularly relevant to disadvantaged communities throughout the developing world where most wars are currently being fought. This project assembles an international and multidisciplinary team of collaborators to conduct bioarchaeological investigations on two large composite skeletal samples from Croatia. The two composite series represent individuals who inhabited Croatia throughout: a) the Late Medieval period (1100-1400 AD) a period of relative prosperity and peace prior to the arrival of Ottoman Turks, and b) individuals who inhabited Croatia in the Historic period (1400-1700 AD) during which time the Ottoman Empire gradually expanded into East and Central Europe. The research will reconstruct Historic period health, diet, weaning practices, and disease and trauma patterns by comparing them with data from the Late Medieval period using bioarchaeological, paleopathological and stable isotope analyses of human burials from Croatia. The project is a collaboration between researchers and postgraduate students who specialize in bioarchaeology, paleopathology, paleodemography, paleodontology, radiology and stable isotope analyses from four institutions: the Croatian Academy of Sciences and Arts, the School of Dental Medicine of the University of Zagreb, the Department of Diagnostic and Interventional Radiology of the University Hospital Dubrava, and the McDonald Institute for Archaeological Research of the University of Cambridge. ]]></summary_en></project><project>
<id>1404</id><title_hr><![CDATA[Istraživanje dinamike Jadrana pomoću naprednih mjerenja i metode asimilacije podataka]]></title_hr><title_en><![CDATA[Exploring the Adriatic Sea Dynamics using Advanced Data Assimilation Methods and Measurements]]></title_en><user_id>357</user_id><user_firstLast_name>Ivica Janeković</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2013-11</proposal_call><code>IP-2013-11-5928</code><acronim><![CDATA[ADAM-ADRIA]]></acronim><duration>01.08.2014 - 31.07.2018</duration><status>Završio</status><financ_value>64.803,54 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Geofizika, </scie_field_hr><scie_field_en>Geophysics, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>1044, 1020, 1417, 2898, 3461, 3525, </team_members_id><team_members_names><![CDATA[Milivoj Kuzmić, Mathieu Dutour Sikirić, Zoran Pasarić, Miroslava Pasarić, Stjepan Ivatek-Šahdan, Hrvoje Mihanović, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[Physical Oceanography, Data Assimilation, 4D-Var, ADCP, CTD profiler, Po river dynamics, Dense Water Dynamics, Adriatic Sea]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Using advanced numerical techniques and data assimilation (ROMS 4D-Var) at the same time with modern observations in a dynamically consistent way we aim to improve knowledge of the Adriatic Sea dynamics. During the project we will explore open questions in the field of physical oceanography of the Adriatic Sea: (I) dynamics of the dense water (DW), especially flow at the eastern side of the Adriatic Sea, (II) dynamics of the Po river outflow during stratified and vertically homogeneous conditions, as well as  (III) generation and dynamics of the sharp Istrian temperature and salinity front. In order to capture those phenomena  we plan to use advanced field observations (ADCPs, CTDs, towed CTD profiler, underway ship CTD), as well as high resolution nested numerical models. This type of measurements could arguably prove hypothesis on the importance of the East Adriatic DW contribution to the overall northern Adriatic DW budget. Measuring synchronously at all important entrances of the Kvarner Bay, we can determine time-evolving dynamics of this socio-economically important region. ROMS 4D-Var system is a powerful tool capable to provide insight into a optimal observation setup, predictability and limits of the linearized adjoint techniques for a shelf sea as the Adriatic. Results from the project could serve as basis for other research fields like ocean biology (DW bringing O2 at the bottom), chemistry or geology, or even applied like oil spills, integrated environmental planning where correct dynamics is of a crucial importance. The project team members come from the four institutions: Ruđer Bošković Institute, Faculty of Science, Croatian Meteorological and Hydrological Service, and Hydrographic Institute bringing unique competences for the proposed project to succeed.Last but not least, it is important to emphasize that after the project completion, all the insitu collected and model data will be made available to the scientific and applied research community.]]></summary_en></project><project>
<id>1406</id><title_hr><![CDATA[Uloga biotičkih čimbenika na vitalnost poljskoga jasena (Fraxinus angustifolia Vahl.) u poplavnim šumama Hrvatske]]></title_hr><title_en><![CDATA[The role of biotic agents on vitality of narrow-leafed ash (Fraxinus angustifolia Vahl.) in Croatian floodplain forests]]></title_en><user_id>2886</user_id><user_firstLast_name>Josip Margaletić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2013-11</proposal_call><code>IP-2013-11-4250</code><acronim><![CDATA[FRAXINPRO]]></acronim><duration>13.06.2014 - 12.06.2018</duration><status>Završio</status><financ_value>124.759,44 eur</financ_value><scie_area_hr>Biotehničke znanosti, Prirodne znanosti, Biomedicina i zdravstvo, </scie_area_hr><scie_area_en>Biotechnical sciences, Natural sciences, Biomedicine and health sciences, </scie_area_en><scie_field_hr>Šumarstvo, </scie_field_hr><scie_field_en>Forestry, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet šumarstva i drvne tehnologije]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Forestry and Wood Technology]]></institution_en><team_members_id>5650, 5656, 3892, 4036, 3748, 727, 4230, 3731, 3754, 5989, 6347, 5242, 5801, 5291, 5641, 6605, 4731, 3730, 5905, 3750, 6189, 1128, 17430, 19025, </team_members_id><team_members_names><![CDATA[Ante Tadin, Dario Baričević, Marko Vucelja, Linda  Bjedov, Milivoj Franjevic, Boris Hrašovec, Kristijan Tomljanović, Marijan Grubešić, Stjepan Mikac, Daniela Pilarska, Renata Pernar, Zrinka Štritof Majetić, Nenad Turk, Josipa Habuš, Petra Svoboda, Mario Ančić, Chandelier Anne, Danko Diminić, LUCIO MONTECCHIO, Marno Milotić, Thomas Cech, Davorin Kajba, Ivan Andrić, Jelena Kranjec, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[Fraxinus angustifolia, vitality, biotic agents, floodplain forests, modelling]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Close to half of the Croatian flood plain forests (67 470 ha) are represented by narrow-leaf ash (Fraxinus angustifolia), covering 29 748 ha in major river basins. Respective welfare value of these forests amount to 6,4 billion €, 2,8 billion € being attributed exclusively to ash forests. Growing stock in narrow-leafed ash forests reaches 4,3 million m3, binding 11,8 million tons of carbon dioxide acting as an important carbon sink depository. Natural and artificial regeneration of ash stands is under direct impact of numerous biotic and abiotic factors, many of which seriously hamper the viability of ash. Insect pests, pathogenic fungi, large game ungulates and ruminantes and small rodent populations play dominant role in the complex processes of tree decline and stand deterioration. Additionally, in the course of recent Europe-wide dramatic spread of newly identified lethal disease on ashes (Chalara fraxinea), introduction of a highly damaging Emerald Ash Borer (Agrilus planipennis) on the eastern borders of Europe, and increased frequency of climatic extremes urge the need to intensify the research of this phenomena. Through an integrated, multidisciplinary approach, in the course of 4 years, the proposed research project targets on several critical aspects of aforementioned biotic detrimental factors analyzing them in the given area and time and aiming to provide a multitude of new details on the mechanisms of their impact. Modern methodological approach covers the following major research topics: presence, local impact and ash disease spread and host resistance tests; additive impact of ash defoliators in the course of recent decline and possibility to manage their populations via entomopathogenic organisms; the impact of small rodents on tree regeneration, acting also as an important human diseases reservoir; negative impact of large game in ash regeneration; geospatial and temporal analysis of major biotic influences in given forest communities. ]]></summary_en></project><project>
<id>1407</id><title_hr><![CDATA[Stohastičke metode u analitičkim i primijenjenim problemima]]></title_hr><title_en><![CDATA[Stochastic Methods in Analytical and Applied Problems]]></title_en><user_id>145</user_id><user_firstLast_name>Zoran Vondraček</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2013-11</proposal_call><code>IP-2013-11-3526</code><acronim><![CDATA[SMAAP]]></acronim><duration>01.09.2014 - 31.08.2018</duration><status>Završio</status><financ_value>58.289,35 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Matematika, </scie_field_hr><scie_field_en>Mathematics, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>522, 790, 570, 740, 781, 987, 793, 760, 1087, 853, 635, 1447, 999, 577, 19109, 19068, </team_members_id><team_members_names><![CDATA[Hrvoje Šikić, Bojan Basrak, Miljenko Huzak, Vjekoslav Kovač, Ante Mimica, Nikola Sandrić, Danijel Krizmanić, Ivana Geček Tuđen, Azra Tafro, Drago Špoljarić, Vanja Wagner, Tvrtko Tadić, Kristina Ana Škreb, Snježana Lubura, Hrvoje Planinić, Stjepan Šebek, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[stochastic methods, stochastic processes, Markov processes, martingales, heavy tails, point processes, branching processes]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[In this project we apply modern stochastic methods to study a number of analytical and applied problems. Many phenomena in science and everyday life exhibit inherent uncertainty. We commonly use stochastic models to describe such behaviour and rely on stochastic methods to gain insights, make forecasts or inference about them. Various stochastic methods have appeared over the years in biology, medicine, biomedicine, geology, climatology, social sciences, finance and insurance, and many other scientific fields. The area of mathematics that lies in the background is probability theory, in particular, theory of stochastic processes. It is a rich mathematical theory with proven potential to solve not only applied problems, but also some quite theoretical problems coming from other areas of mathematics.The problems that we plan to study can be broadly divided into four groups: 1. Analysis and potential theory of Markov processes, 2. Stochastic methods in modelling heavy tailed phenomena, 3. Stochastic methods in harmonic analysis, and 4. Stochastic methods in biomedical and social sciences problems. This choice of problems is influenced by importance in the current international research as well as the background and expertise of members of our team. The goal of the project is to advance understanding of the role of randomness in each of these four settings. The unifying feature behind our approach to these problems is common stochastic methods in their analysis. These methods include, but are not limited to, martingale methods, point processes and random measure methods, potential-theoretic methods (both probabilistic and analytic), Markov processes methods, methods from the Dirichlet form theory, stochastic integrals, diffusion processes, branching processes and measure-valued processes methods, time-series methods, wavelets and methods for statistical inference.]]></summary_en></project><project>
<id>1415</id><title_hr><![CDATA[Dizajn, sinteza i evaluacija novih protuotrova kod trovanja živčanim bojnim otrovima i pesticidima]]></title_hr><title_en><![CDATA[Design, synthesis and evaluation of new antidotes in nerve agent and pesticide poisoning]]></title_en><user_id>872</user_id><user_firstLast_name>Zrinka Kovarik</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2013-11</proposal_call><code>IP-2013-11-4307</code><acronim><![CDATA[CHOLINESTERASE]]></acronim><duration>01.09.2014 - 31.08.2018</duration><status>Završio</status><financ_value>132.715,75 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, </scie_field_hr><scie_field_en>Chemistry, </scie_field_en><institution_hr><![CDATA[Institut za medicinska istraživanja i medicinu rada]]></institution_hr><institution_en><![CDATA[Institute for Medical Research and Occupational Health]]></institution_en><team_members_id>982, 991, 489, 1224, 601, 411, 657, 3033, 3076, 5926, 17747, </team_members_id><team_members_names><![CDATA[Maja Katalinić, Anita Bosak, Goran Šinko, Gordana Mendaš Starčević, Vladimir Vinković, Nikolina  Maček Hrvat, Nikola Maraković, Suzana Žunec, Ana Lucić Vrdoljak, Zoran Radić, Tamara Zorbaz, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[acetylcholinesterase, butyrylcholinesterase, bioscavengers, prophylaxis, in silico drug-design, oximes, bronchodilatators]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Our main goal is to develop new compounds to serve as more efficient antidotes and improve the treatment of highly toxic organophosphorus (OP) compound poisoning. OP compounds used as pesticides account for over 3,000,000 registered accidental or deliberate cases of poisoning per year worldwide. Furthermore, OPs known as nerve agents (soman, sarin, tabun, VX) present a threat in terrorist attacks and conflicts, as was the case recently in Syria. The main targets of OP compounds are cholinesterases: acetylcholinesterase (AChE), the essential enzyme in neurotransmission, and butyrylcholinesterase (BChE), its back-up enzyme. However, the antidotes currently in use, which act as reactivators of inhibited AChE, were empirically synthesized before the two enzyme’s crystal structures were resolved. Due to structural requirements, their binding affinity and reactivation rate have not been well-balanced. This project utilizes new compounds to gain a better understanding of the mechanistic basis of the limitations of reactivation and find new effective leads for further in vivo study. We will combine several approaches, including: a study of the finely tuned interplay between these two sister enzymes, computational and experimental studies of cholinesterase interactions with a wide range of ligands defining favourable characteristic for potential new antidotes, in silico design of novel compounds that will direct the subsequent synthesis of selected leads, and thorough in vitro and in vivo experimental evaluation guided by strict cost-benefit criteria. Such a comprehensive approach will enable us to test a wide selection of candidates in a more reliable manner and obtain unambiguous data for further enhancements of the antidotal treatment. This will also enable us to explore other possible OP treatments such as highly-effective bioscavengers. Many of the findings that would arise from this project should have an impact that reaches far beyond the level of cholinesterases.]]></summary_en></project><project>
<id>1417</id><title_hr><![CDATA[MOLEKULARNI MEHANIZMI POVEĆANJA OSJETLJIVOSTI NA PROTUTUMORSKE LIJEKOVE STANICA KARCINOMA DOJKE I MELANOMA ČOVJEKA UTIŠAVANJEM INTEGRINA]]></title_hr><title_en><![CDATA[MOLECULAR MECHANISMS OF CHEMOSENSITISATION OF HUMAN BREAST CARCINOMA AND MELANOMA CELL LINES BY SILENCING OF INTEGRINS]]></title_en><user_id>1211</user_id><user_firstLast_name>Andreja Ambriović Ristov</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2013-11</proposal_call><code>IP-2013-11-2465</code><acronim><![CDATA[INSILCELL]]></acronim><duration>01.09.2014 - 31.08.2018</duration><status>Završio</status><financ_value>132.533,26 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Biologija, </scie_field_hr><scie_field_en>Biology, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>1380, 3536, 3899, 2888, 3147, 420, 6232, </team_members_id><team_members_names><![CDATA[Maja Osmak, Mario Cindrić, Sanjica Rak, Nikolina Stojanović, Tihana De Zan, Ana Dekanić, Mladen Paradzik, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[breast cancer, melanoma, signalling pathways, anticancer drug resistance, focal adhesion, migration, invasion]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[The recognition of molecular mechanisms involved in drug resistance may improve basic knowledge of signalling pathways involved in resistance to anticancer drugs and also improve outcomes in patients with drug-resistant cancers that have poor prognosis, such as triple negative breast cancer (TNBC) and metastatic melanoma. Integrins are cell surface molecules that mediate sensitivity to anticancer drugs, migration and invasion, and therefore represent a suitable target for therapy. This proposal investigates the molecular mechanism behind knockdown of integrins alpha v beta 3, alpha v beta 5, alpha v beta 6, alpha 3 beta 1, alpha 4 beta 1 and alpha 5 beta 1 using integrin subunit specific siRNAs (beta 3, beta 5, beta 6, alpha v, alpha 3, alpha 4 or alpha 5) and the ability of such a treatment to sensitise TNBC and melanoma cell lines to anticancer drugs paclitaxel, vincristine and cisplatin. Our next goal is to identify how specific integrin knockdown influences cell migration and invasion. The focal adhesions (FA) are sites of attachment between cells and extracellular matrix which may mediate differential cell responses by variation of FA protein composition. Therefore, the FA protein composition will be investigated before and upon integrin silencing using proteomics methodology. We will monitor formation and temporal evolution of FA in living cells during spreading or migration using reflection interference contrast microscopy (RICM). On the basis of these data, several signalling pathways will be proposed and their involvement in sensitivity to anticancer drugs, migration and invasion will be experimentally verified. Our data will contribute to the knowledge on integrin signalling pathways, structure and function of focal adhesions. The understanding of integrin pathways involved in sensitivity to anticancer drugs, migration and invasion processes may provide novel insights into biology of these cancer cells and identify new target molecules in TNBC or melanoma.]]></summary_en></project><project>
<id>1421</id><title_hr><![CDATA[Transformacije kolektivnih i individualnih identiteta u Dubrovačkoj Republici od kasnog srednjeg vijeka do 19. stoljeća]]></title_hr><title_en><![CDATA[Transformations of the Collective and Individual Identities in the Dubrovnik Republic from the Late Middle Ages until the Nineteenth Century]]></title_en><user_id>393</user_id><user_firstLast_name>Nenad Vekarić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2013-11</proposal_call><code>IP-2013-11-5106</code><acronim><![CDATA[COLINDA]]></acronim><duration>01.07.2014 - 30.06.2018</duration><status>Završio</status><financ_value>78.306,46 eur</financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Povijest, </scie_field_hr><scie_field_en>History, </scie_field_en><institution_hr><![CDATA[Hrvatska akademija znanosti i umjetnosti]]></institution_hr><institution_en><![CDATA[Croatian Academy of Sciences and Arts]]></institution_en><team_members_id>384, 386, 389, 398, 481, 458, 726, 739, 430, 1091, 1097, 1115, 1112, 1254, 330, </team_members_id><team_members_names><![CDATA[Ivana Lazarević, Nella Lonza, Rina Kralj-Brassard, Relja Seferović, Vesna Miović, Stanislava (Slavica) Stojan, Lovro  Kunčević, Zdenka Janeković Roemer, Irena Ipšić, Antun Koncul, Kristina Puljizević, Marija Gjurašić, Marinko Marić, Štefica Curić Lenert, Zrinka Pešorda Vardić, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[Dubrovnik, Identity, Middle Ages, Early Modern Period, cultural history]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[The proposed project is an interdisciplinary study of various forms of identity in the Republic of Dubrovnik during almost half a millennium of its independent statehood (mid 14th – early 19th century). Adopting a broad perspective it will take into account most diverse aspects of identity, such as social, political, religious, ethnic, or individual, as well as their interactions. This requires investigation of diverse historical sources which range from texts (e.g. historiography, diplomatic correspondence, notary records), to social practices (e.g. ritual) or urban topography and visual arts. Besides such comprehensiveness, another important novelty of the project is its chronological scope. It takes into account long period of almost half a millennium, thereby disregarding the conventional divide between the Middle Ages and the Early Modern Period, which will enable valuable insights into long term (dis)continuities. Yet another important novelty is that the project focuses on a premodern city-state, a type of community relatively neglected in the field of identity studies mostly focused on modern period and national states. Finally, the project will also adopt a strongly comparative perspective, investigating the (dis)similarities between Dubrovnik and other Mediterranean cities.Since the enterprise of this scope necessarily involves specialists in different fields and methodologies, the project assembles an interdisciplinary team led by the Academician Nenad Vekarić. It consists of ten scientists, two postdoctoral researchers and four doctoral students. The project proposes to publish more than 10 scientific books, numerous articles, and organize four workshops. Besides offering the answer to an important scientific problem, the main objective of the project is to present to the international audiences the less known but important case of Dubrovnik, thus contributing to the visibility and networks of Croatian scholars. ]]></summary_en></project><project>
<id>1422</id><title_hr><![CDATA[Aproksimacija ovisna o konfiguraciji u nelinearnoj analizi konstrukcija metodom konačnih elemenata]]></title_hr><title_en><![CDATA[Configuration-dependent Approximation in Non-linear Finite-element Analysis of Structures]]></title_en><user_id>527</user_id><user_firstLast_name>Gordan Jelenić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2013-11</proposal_call><code>IP-2013-11-1631</code><acronim><![CDATA[CANFAS]]></acronim><duration>01.09.2014 - 31.08.2018</duration><status>Završio</status><financ_value>124.557,44 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Temeljne tehničke znanosti, </scie_field_hr><scie_field_en>Basic engineering sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Građevinski fakultet u Rijeci]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Civil Engineering]]></institution_en><team_members_id>1064, 1014, 906, 856, 3167, 19011, 17756, 22702, </team_members_id><team_members_names><![CDATA[Paulo Šćulac, Dragan Ribarić, Leo Škec, Maja Gaćeša, Edita Papa Dukić, Nina Čeh, Sara Grbčić, Miran Tuhtan, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[non-linear structural analysis, finite-element method, configuration-dependent approximation, beams, shells, dynamics]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[This proposal explores the configuration-dependent interpolation as a novel, unorthodox and remarkably promising expansion of the framework within which the non-linear finite-element method has been traditionally contained. The basic idea underlying the project stems from an apparent disparity between the rather advanced extensions of the traditional linear finite-element principles to non-linear problems and the fact that the key finite-element concept – that of interpolation of the unknown functions – is surprisingly kept mostly constant, i.e. configuration-independent. Enabling the finite-element approximation to become configuration-dependent is motivated by the existing need to improve the current non-linear finite-element procedures, in particular for mechanical problems defined on non-linear manifolds. This principle is presented as the general concept providing viable novel development paradigm with obvious benefits for a wider class of mechanical problems. The configuration-dependent approximation to be designed shall obey the essential convergence requirements, with its extra flexibility (arising from the potential of the new approximation to vary with the configuration) employed to improve the solution in some clearly defined manner. In particular, during the design process, the following two basic principles will be consistently adhered to:(i) In the limiting case where the non-linear mechanical problem becomes linear, the configuration-dependent approximation sought must coincide with a known reference interpolation for linear analysis.(ii) In a general non-linear situation, the configuration-dependent approximation should preserve a set of selected mechanical or mathematical properties of equilibrium or motion defined beforehand.In this way, a variety of finite-elements for static and dynamic analysis will be derived.]]></summary_en></project><project>
<id>1423</id><title_hr><![CDATA[Inovativno pametno poduzeće]]></title_hr><title_en><![CDATA[Innovative Smart Enterprise]]></title_en><user_id>2921</user_id><user_firstLast_name>Ivica Veža</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2013-11</proposal_call><code>IP-2013-11-1353</code><acronim><![CDATA[INSENT]]></acronim><duration>01.09.2014 - 31.08.2018</duration><status>Završio</status><financ_value>95.825,87 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Strojarstvo, </scie_field_hr><scie_field_en>Mechnical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Splitu, Fakultet elektrotehnike, strojarstva i brodogradnje]]></institution_hr><institution_en><![CDATA[University of Split, Faculty of Electrical Engineering, Mechanical Engineering and Naval Architecture]]></institution_en><team_members_id>3561, 5080, 4743, 5276, 5799, 5752, 18966, 18965, 18956, 17852, </team_members_id><team_members_names><![CDATA[Marko Mladineo, Željko Stojkić, Zoran Babić, Nikola Gjeldum, Stipe Čelar, Boženko Bilić, Nikola Banduka, Igor Bošnjak, Mii Turić, Ivan Peko, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[innovation, smart enterprise, learning factory, production systems, business model]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[The introduction of the Internet of Things and Services into the manufacturing environment is ushering in a fourth industrial revolution: Industry 4.0. This new type of industry is based on Smart Factory model or Smart Enterprise. The main features of Smart Enterprise can be summarized into the following: smart personalized product, product and service provider, and high level of collaboration.Manufacturing is today, as it always has been, a cornerstone of the economy of developed nations. An important advantage of manufacturing is that it calls on the skills of everyone from entry-level factory workers to scientists, engineers, and business professionals. Hence, main focus of this project will be Manufacturing Enterprises. Vision of Innovative Smart Enterprise for next generation manufacturing can be summarized into following features: Lean, Flexible, Agile, Efficient, Responsive, Information Enabled, Predictive, and Safe. All these features result with long term sustainability.The main objective of this project is to develop Croatian model of Innovative Smart Enterprise (HR-ISE model). Hence, a profound research will be performed to describe current state of Croatian manufacturing enterprise. It will be the answer on the question: “Where are we?”Furthermore, a synthesis of analysis of Croatian manufacturing enterprises will be done through development of HR-ISE model. It will be the answer on the question: “Where we want to be?”Finally, a special learning environment will be established: Learning Factory. It will be a place in which transfer of developed HR-ISE model to the economy subjects will be achieved. It will be the answer on the question: “How can we get there?”Results of this project will be of the highest value for “fallen” Croatian industry. The development of HR-ISE model and its transfer to economy can have strong impact on recovery of Croatian industry, and it can significantly improve competencies and capabilities of Croatian enterprises.]]></summary_en></project><project>
<id>1427</id><title_hr><![CDATA[Kompetencijski profil akademske profesije: između novih zahtjeva i mogućnosti]]></title_hr><title_en><![CDATA[Academic Profession Competence Framework: Between New Requirements and Possibilities]]></title_en><user_id>380</user_id><user_firstLast_name>Jasminka Ledić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2013-11</proposal_call><code>IP-2013-11-2004</code><acronim><![CDATA[APROFRAME]]></acronim><duration>01.06.2014 - 31.05.2017</duration><status>Završio</status><financ_value>38.783,57 eur</financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Pedagogija, </scie_field_hr><scie_field_en>Pedagogy, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Filozofski fakultet u Rijeci]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Humanities and Social Sciences]]></institution_en><team_members_id>2588, 500, 18914, 18911, </team_members_id><team_members_names><![CDATA[Bojana Ćulum, Marko Turk, Marija Brajdić Vuković, Bojana Vignjevic, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[higher education, academic profession, competence framework, academic roles, higher education policy]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Changes in social environment indicate the need for a redefinition of the academic profession’ traditional role and for its more comprehensive understanding, which leads to the requirements for the development of new competences. Research results indicate the increased scope of workload and demands for new approaches to teaching, disharmony between teaching and research, increasing administrative duties, and the insistence on a stronger connection between the academic community and social environment.This project aims to determine how academics in Croatia assess the relevance of various competences, and how they assess, perceive and interpret possession of various competences that shape contemporary academic profession. It is expected that the research results in a proposal of the academic profession’ competence framework.In the research quantitative and qualitative methodological approach (survey and semi-structured interview) will be used. The survey consists of the competence framework elements which are to be evaluated by the participants in terms of the assessment of their (1) relevance and (2) possession. The interviews will explore the deeper perception of academics and challenging issues within the framework, and gain a ‘holistic’ (comprehensive, systemic, integrated) understanding of context, while capturing data on the participants perceptions ‘from the inside’.The final definition of an integrated competence framework which includes different dimensions of the academic profession is an original research contribution. Bearing in mind that the research of the academic profession is neglected in the national research discourse, the results of this study will also be a starting point for defining recommendations for (national) educational policies. This will particularly apply to profiling the academic profession in the context of recent strategic directions in Croatia, in accordance with the requirements of the international scientific community.]]></summary_en></project><project>
<id>1431</id><title_hr><![CDATA[Anaerobni kapaciteti  u udaračkim borilačkim sportovima]]></title_hr><title_en><![CDATA[Anaerobic capacities in kicking combat sports]]></title_en><user_id>784</user_id><user_firstLast_name>Dražen Čular</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2013-11</proposal_call><code>UIP-2013-11-6524</code><acronim><![CDATA[ACIKCS]]></acronim><duration>15.06.2014 - 14.03.2018</duration><status>Završio</status><financ_value>52.659,13 eur</financ_value><scie_area_hr>Društvene znanosti, Biomedicina i zdravstvo, Tehničke znanosti, </scie_area_hr><scie_area_en>Social sciences, Biomedicine and health sciences, Technological sciences, </scie_area_en><scie_field_hr>Kineziologija, </scie_field_hr><scie_field_en>Kinesiology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Splitu, Kineziološki fakultet]]></institution_hr><institution_en><![CDATA[University of Split, Faculty of Kinesiology]]></institution_en><team_members_id>3449, 1463, 3312, 4560, 3813, 4737, 17896, 18978, </team_members_id><team_members_names><![CDATA[Alen Miletić, mirjana milić, Goran Kuvačić, Vladimir Ivancev, TEA BEŠLIJA, Damir Zubac, Luka Pezelj, Johnny Padulo, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[anaerobic capacity, combat sport, test construction, taekwondo, karate, kickboxing, fitness  tests,  ]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[The main aim of the project is to construct and validate a measuring instrument of good metric characteristics and with high applicability that will, in a quality way, describe the level of specific anaerobic capacities in kicking combat sports (taekwondo, karate, kickboxing). Due to the complexity of the problems regarding the object of research, and in case the newly constructed test does not show satisfactory metric characteristics, a secondary aim is set which entails revalidation and selection of one or more existing “non-specific” tests which will be proven appropriate for each sport after testing the metric characteristics. The project is designed as a research in duration of 36 months. For the purposes of realization of the aims set, the research will be conducted on a sample of 300 subjects minimum, divided into subsamples according to sport, gender and age category (cadets, juniors, seniors). The project consists of three phases. In the first phase a Web page and computer application will be created for: input, storage, reviewing and monitoring of subjects and results, and, based on a pilot study and previous findings, a certain number of the existing “non-specific” measuring instruments will be selected. In the second phase of the project data will be collected on anthropometric characteristics and the level of anaerobic capacities of the subjects will be measured by field tests with confirmed metric characteristics. At the same time, the construction of a new specific measuring instrument will begin during the second phase. The third phase of the project includes the testing of metric characteristics of the newly constructed specific field test for assessing anaerobic capacities in kicking combat sports, as well as the selection of the existing tests appropriate for practical application on a specific sample. After the project is finished, selection normative according to sport, gender and age category will be created based on the obtained results.]]></summary_en></project><project>
<id>1440</id><title_hr><![CDATA[Dokumentiranje i interpretiranje najstarijih razdoblja hrvatskoga jezika]]></title_hr><title_en><![CDATA[Documentation and Interpretation of the Earliest Croatian]]></title_en><user_id>995</user_id><user_firstLast_name>Amir Kapetanović</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2013-11</proposal_call><code>IP-2013-11-2698</code><acronim><![CDATA[DOCINEC]]></acronim><duration>01.07.2014 - 30.06.2018</duration><status>Završio</status><financ_value>56.539,25 eur</financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Filologija, </scie_field_hr><scie_field_en>Philology, </scie_field_en><institution_hr><![CDATA[Institut za hrvatski jezik]]></institution_hr><institution_en><![CDATA[Institute of Croatian Language]]></institution_en><team_members_id>3723, 5648, 5864, 5965, 3726, 6131, 5332, </team_members_id><team_members_names><![CDATA[Dunja Brozović Rončević, Željka Brlobaš, Vuk-Tadija Barbarić, Saskia Elisabeth Pronk-Tiethoff, Tijmen Pronk, Dubravka Ivšić, Branimir Brgles, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[Old Croatian, Proto-Slavic, onomastics, earliest linguistic attestations, loanwords, issogloses]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[The oldest Slavic language attestations on Croatian territory date from two periods - the first which saw the disintegration of Common Slavic (9th-11th c.), and the second which saw the beginnings of the Croatian language (12th-13th c.). This Slavic vernacular, which was the direct predecessor of present-day Croatian, coexisted with the liturgical Croatian Church Slavic, whose oldest written texts can be dated to the 11th c. The earliest attestations of the Croatian language are scattered throughout written sources of various nature, from individual words found in Latin and Church Slavic texts, glosses, and notes in the margins of medieval codices to Glagolitic epigraphs. This language has not yet been analyzed in its entirety.The backbone of the project will be formed by a corpus of the earliest attested Croatian lexical data. Such a corpus does not yet exist. This early Croatian corpus will reflect the development of the languages between the 9th and 13th centuries, some of the earliest isoglosses between Croatian and other Slavic languages, as well as some of the earliest Croatian dialectal isoglosses and interaction with western European – especially Romance and Germanic – and eastern European cultural and linguistic entities. The earliest onomastic data of Slavic origin plays an important role in this research.The research will be conducted using the traditional methods and tools of historical linguistics, such as text analysis and interpretation and the comparative method. The research team consists of four researchers and five junior researchers from a number of academic institutions (Zagreb, Zadar, Leiden).The aims of the proposed project are: (1) to create a complete collection of the oldest attestations of the Croatian language; (2) to improve our understanding of the structural changes in early Croatian and the rise of the earliest isoglosses within Croatian; (3) to place the beginnings of the Croatian language in a wider Slavic and non-Slavic context.]]></summary_en></project><project>
<id>1442</id><title_hr><![CDATA[Mulitidisciplinarni pristup otkriću lijekova s ciljanim djelovanjem na matične stanice tumora – uloga transporta kalija ]]></title_hr><title_en><![CDATA[A multidisciplinary approach to discover selective drugs targeting cancer stem cells: The role of potassium transport ]]></title_en><user_id>613</user_id><user_firstLast_name>Marijeta Kralj</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2013-11</proposal_call><code>IP-2013-11-5660</code><acronim><![CDATA[MultiCaST]]></acronim><duration>01.10.2014 - 28.02.2019</duration><status>Završio</status><financ_value>131.589,36 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo, Prirodne znanosti, Biotehničke znanosti, </scie_area_hr><scie_area_en>Biomedicine and health sciences, Natural sciences, Biotechnical sciences, </scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>629, 859, 2607, 3445, 647, 3806, 1421, 698, 17804, 21401, </team_members_id><team_members_names><![CDATA[Marko Marjanović, Katja Ester, Irena Martin-Kleiner, Ana-Matea Mikecin, Lidija Uzelac, Tomislav Šmuc, Fran Supek, Kata Majerski, Iva Guberović, Marija Ćosić, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[cancer stem cells, potassium transport, salinomycin, crown ethers, ion channels, ABC transporters, predictive QSAR modeling, drug discovery, therapy]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Targeting cancer stem cells (CSC), rather than cancer cells in general, is a novel and highly promising strategy for cancer treatment. The defining characteristics of CSC are self-renewal, propagation into heterogeneous lineages of cancer cells, and increased resistance to chemotherapy, thus, attacking the CSC should abolish a tumor&#39;s ability to recur or metastasize. Recently, a natural potassium ionophore salinomycin was identified as one of a few available CSC-selective substances, but the precise mechanism of its selectivity remains elusive. Based on hypothesis that the potassium transport is an important process of CSC biology, the objective of the proposed research is to understand fundamental processes of CSC-resistance to therapy and to discover novel compounds with ion homeostasis-modulating properties to selectively target CSC. Project methodology orchestrates research in three principle areas and their close interactions, covering synthesis and characterization of molecules (chemistry), assessment of their activity in biological models (biology, medicine) and computer-aided drug design (computational sciences). We’ll focus on salinomycin and a series of proprietary crown ether compounds, which will be optimized and developed. Their efficacy/selectivity and influence on drug transporters P-gp- and/or ABCG2-mediated efflux of chemoterapeutics will be assessed, as well as the toxicity and in vivo activity of the most promising compound. Deploying cutting-edge techniques in cell and molecular biology, bioimaging, molecular electrophysiology and transgenic cell lines (e.g. a unique CSC model - HMLEshEcad cells) we will strive to recognize novel biomarkers for identification and enrichment of CSC, related to abnormal potassium transport regulation that promote acquisition of CSC phenotype and/or influence their proliferation, death and migratory potential. The ultimate aim is to translate this knowledge into innovative mechanism-based therapeutic approaches. ]]></summary_en></project><project>
<id>1445</id><title_hr><![CDATA[Kateterska denervacija pulmonalnih arterija u liječenju primarne i sekundarne plućne hipertenzije]]></title_hr><title_en><![CDATA[CATHETER DENERVATION OF PULMONARY ARTERIES IN THE TREATMENT OF PRIMARY AND SECONDARY PULMONARY HYPERTENSION]]></title_en><user_id>315</user_id><user_firstLast_name>Aleksander Ernst</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2013-11</proposal_call><code>IP-2013-11-2505</code><acronim><![CDATA[CADOPA]]></acronim><duration>01.07.2014 - 30.06.2018</duration><status>Prekinut</status><financ_value>132.722,81 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Kliničke medicinske znanosti, </scie_field_hr><scie_field_en>Clinical sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb School of Medicine]]></institution_en><team_members_id>1334, 1092, 1021, 985, 3393, 3452, </team_members_id><team_members_names><![CDATA[Jadranka Šeparović Hanževački, Mladen Vidovich, Boško Skorić, Joško Bulum, Maja Strozzi, Miroslav Samarzija, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[idiopathic pulmonary hypertension, secondary pulmonary hypertension, radiofrequency denervation, cryodenervation, pulmonary arteries]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[The role of neural reflexes in the mediation and development of idiopathic pulmonary artery hypertension (IPAH) and secondary pulmonary artery hypertension (SPAH) has not been adequately investigated. The existence of a pulmopulmonary baroreceptor reflex that originates in the large pulmonary branches, unrelated to the vagus nerve has been reported (1,2,3).Very recently, experimentally induced acute pulmonary hypertension in 10 Mongolian dogs was completely abolished by radiofrequency pulmonary artery denervation at the main bifurcation area of the left pulmonary artery (4). Also,the effect of radiofrequency pulmonary artery denervation on functional capacity and hemodynamics showed significant reduction of mean pulmonary artery pressure (PAP) in 13 patients with IPAH not responding optimally to medical therapy(5).The aim of research proposal is to assess and compare the safety and efficacy of radiofrequency and cryodenervation of pulmonary arteries on decrease in pulmonary vascular resistance in 20 patients with IPAH (mean pulmonary artery pressure >25 mmHg) and in 20 patients with secondary pulmonary hypertension due to pulmonary disease or due to left heart disease not responding optimally to medical therapy.Already well established and aproved radifrequency and cryo ablation technology modified for pulmonary artery denervation will be utilized in proposed clinical trial of new indication. All procedures will be performed in the Clinical Hospital Center Catheterization laboratory. Proposed duration of the trial is 4 years. Expected scientific contribution of this clinical trial might provide invaluable impact on improvement of quality of life and possibly on a deacrease in mortality of patients with pulmonary hypertension. Positive results of proposed study might generate several scientific publications, doctoral theses and above all would strengthen the international scientist collaboration and reputation of Medical Faculty of University of Zagreb.]]></summary_en></project><project>
<id>1447</id><title_hr><![CDATA[Otkrivanje novih genetskih lokusa uključenih u regulaciju funkcije štitne i doštitne žlijezde]]></title_hr><title_en><![CDATA[Identification of new genetic loci implicated in regulation of thyroid and parathyroid function]]></title_en><user_id>118</user_id><user_firstLast_name>Tatijana Zemunik</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2013-11</proposal_call><code>IP-2013-11-1498</code><acronim><![CDATA[THYPARATHYFUNCTION]]></acronim><duration>15.09.2014 - 31.12.2018</duration><status>Završio</status><financ_value>112.814,39 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Splitu, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Split School of Medicine]]></institution_en><team_members_id>137, 588, 611, 262, 3571, 4137, 17479, 19036, 23035, </team_members_id><team_members_names><![CDATA[Maja Barbalić, Dubravka Brdar, Vesela Torlak, Bernarda Lozić, Ante Punda, Caroline Hayward, Antonela Boljat, Ivana Gunjača, Marijana Popović, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[thyroid function, parathyroid function, genetic variants, polymorphisms, genome-wide study, gene-environmental interaction, complex phenotypes]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Thyroid diseases affect up to 10% of the general population creating an important public health problem. Parathyroid diseases are less frequent but not insignificant. Thyroid hormones act on every tissue regulating cellular development, differentiation and metabolism. Parathyroid hormones control the amount of calcium in the blood. The expression of thyroid and parathyroid hormones/antibodies is under polygenic control and influenced by environmental factors. The aim of this study is to identify genetic loci that are associated with levels of thyroid/parathyroid hormones and antibodies that will advance our understanding of the genetic basis of their function and thus provide additional knowledge relevant to clinical outcomes.  We will perform genome-wide association analysis of thyroid and parathyroid hormones/antibodies on 1,000 individuals from Split region (participants from the 10,001 Dalmatians project). The thyroid and parathyroid hormones/antibodies that are planned to be analysed are: free triiodothyronine, free thyroxine, thyroid-stimulating hormone, thyroglobulin, thyroid microsomal antibody titer, thyroglobulin antibody titer and parathiroid hormone. In addition, detailed anamnestic data and phenotype measurements already taken from study participants will be used in realization of second and third project objectives: investigation of relevant gene-environment interactions and determination of phenotype-phenotype correlation. We plan to follow-up interesting findings in additional 2,000 individuals and in datasets sought through international collaboration.Outcomes of such comprehensive approach will be generation of a new knowledge of genetic background, gene-environment interaction and phenotype-phenotype correlation associated with thyroid and parathyroid function that will lead to better understanding of biological pathways and clinically relevant disorders related to their function. The obtained results will promote excellence of Croatian research.]]></summary_en></project><project>
<id>1451</id><title_hr><![CDATA[Otkrivanje novih proteinskih interakcija kao podloga za nove pristupe liječenju melanoma čovjeka]]></title_hr><title_en><![CDATA[New protein networks for novel therapeutic avenues in human melanoma]]></title_en><user_id>649</user_id><user_firstLast_name>Neda Slade</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2013-11</proposal_call><code>IP-2013-11-1615</code><acronim><![CDATA[ProNetMel]]></acronim><duration>01.09.2014 - 31.01.2019</duration><status>Završio</status><financ_value>120.558,76 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>1107, 3089, 942, 3401, 1322, 712, 1033, 2812, 1470, 17835, 15915, </team_members_id><team_members_names><![CDATA[Maja Herak Bosnar, Sonja Levanat, Vesna Musani, Mladen Jokić, Anđela Horvat, Petar Ozretić, Diana Car, Božena Šarčević, Ivan Milas, Nikolina Hanžić, Vjekoslav Tomaić, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[melanoma, protein interactions, p53, p73, nm23, Gli]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Metastatic melanoma represents a major clinical problem due to rising incidence and resistance to available therapies. Therefore, there is a necessity for developing novel molecular approaches to treat this disease. Unlike other tumors, in melanoma p53 is relatively rarely mutated. However, overexpressed p53 fails to function as a tumor suppressor and tumor cells continue to proliferate and spread. This suggests that regulation of p53 activity depends on the interplay between p53 and its binding partners. Based on current state of knowledge, we hypothesize that p53 function in malignant melanoma might be altered through the interactions with p53 small molecular weight and p73 isoforms, nm23/NDPK and Gli families of proteins. Thus we will search for p53 protein binding partners in melanoma. The interactions identified by mass spectrometry will be further confirmed using microarray-based approaches and co-immunoprecipitation techniques. Furthermore, the expression profile of genes/proteins of interest in panel of melanoma cell lines and melanoma tissue samples will be investigated. The potential impact of the identified p53 interacting partners on its transcriptional activity and the stimulation of apoptosis will be determined. The depletion of partners using siRNA technology would confirm the involvement of selected proteins on p53 activity. The subcellular localization of the proteins in complex will be revealed by advanced fluorescent microscopy methods on state-of-the-art instrumentation what would give us the insight on dynamics of their interactions. The proposed research could provide a possible explanation why p53 function in melanoma is abrogated. The aim of this project is to determine the complexity of p53 interactions and their role in the onset and progression of human melanoma and offer new, innovative solutions in diagnosis, prognosis and therapy.]]></summary_en></project><project>
<id>1456</id><title_hr><![CDATA[Automorfne forme, reprezentacije i primjene]]></title_hr><title_en><![CDATA[Automorphic forms, representations, and applications]]></title_en><user_id>820</user_id><user_firstLast_name>Goran Muić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2013-11</proposal_call><code>IP-2013-11-9364</code><acronim><![CDATA[Automorphic forms]]></acronim><duration>01.07.2014 - 30.06.2018</duration><status>Završio</status><financ_value>50.169,22 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Matematika, </scie_field_hr><scie_field_en>Mathematics, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>863, 831, 850, 890, 1154, 1000, 1079, 901, 17779, </team_members_id><team_members_names><![CDATA[Darija Brajković, Iva Kodrnja, Ivan Matić, Neven Grbac, Marko Tadić, Igor Ciganović, Marcela Hanzer, Nevena Jurčević Peček, Sonja Žunar, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[automorphic forms, representations, Eisenstein series, cuspidal forms, theta correspondence]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Recent and major breakthrough in the Langlands programme is a proof of existence endoscopic transfer of representations both local and global automorphic from split classical groups to GL(n) proved mainly by Arthur. Our research proposal  fits very well with this recent development. First of all, the work of Arthur has its local application in  the classification of representations of discrete series that was done by Moeglin and Tadić. Based on those results we plan to pursue the following investigations in the representation theory of p-adic groups.  We would like to compute the Jacquet modules of discrete series representations completely.This will help us understand representations parabolically induced from those discrete series (generalized principal series) completely. This will have consequence on the problems of determination of complementary series for classical groups a problem related to the classification of unitary representations. Results of Gan, Savin and Ichino will help us extend some of those results to metaplectic groups. This will have important consequence on the determination of theta correspondence for dual pairs consisting of odd orthogonal and metaplectic groups such as explicit determination of all theta lifts. In the theory of automorphic forms, we would like to understand the construction of Arthur and Moeglin more explicitly. This will construct new series of square integrable representations; some special cases were obtained earlier by Muić, and Muić and Hanzer.This will give locally many interesting unitary representations which are more complicated than that has appeared in earlier works of Speh, Rogawski, Tadić, Muić, Savin, and Hanzer. We will apply those methods to study cohomology and poles of automorphic L-functions. ]]></summary_en></project><project>
<id>1458</id><title_hr><![CDATA[Razvoj voltametrijskih metoda za karakterizaciju prirodnih antioksidansa]]></title_hr><title_en><![CDATA[Development of voltammetric methods for the characterisation of natural antioxidants]]></title_en><user_id>442</user_id><user_firstLast_name>Šebojka  Komorsky-Lovrić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2013-11</proposal_call><code>IP-2013-11-2072</code><acronim><![CDATA[DVMCNA]]></acronim><duration>01.07.2014 - 30.06.2017</duration><status>Završio</status><financ_value>14.599,51 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, </scie_field_hr><scie_field_en>Chemistry, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>1099, 595, 438, 17762, </team_members_id><team_members_names><![CDATA[Ivana Novak Jovanović, Dijana Jadreško, Milivoj Lovrić, Lara Čižmek, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[voltammetry, antioksidans, radicals, squave wave, simulations]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Oxidant is an ion or a compound that reacts with a certain component of a living cell and oxidizes it. The reactive oxygen species produced in cells include hydrogen peroxide, hypochlorous acid, hydroxyl radical and superoxide anion. Antioxidant is a foreign substance that reacts with the oxidant faster than the components of the cell. An imbalance between oxidants and antioxidants in favour of the oxidants is termed oxidative stress. Antioxidants act as free radical scavengers and therefore can lower the risk of numerous degenerative diseases by preventing damages caused by free radicals. Fruits and vegetables are the major sources of antioxidants in human diet. Several natural compounds found in food, such as polyphenols, vitamins A and E, and some carotenoids, have been found to show excellent antioxidant activity. Chlorophylls and their derivatives have also been reported to possess this activity. However, literature is still scarce regarding their antioxidant properties. It is known that the amount of each antioxidant in fruits, vegetables and their derivatives is strongly influenced by numerous factors such as agro-technical processes, environmental conditions, processing factors and storage conditions. Continuous monitoring of antioxidant capacity of plant-based foods through different phases, from cultivation to storage, is needed to maintain or even improve the beneficial properties of food. The goal of this project is to develop several cyclic multi-pulse voltammetric techniques for the characterization of natural antioxidants and to apply them in routine analysis of food quality. Experimental results will be explained by the comparison with the theoretical simulation of responses of various electrode mechanisms of independent and conjugated multiple redox centers.]]></summary_en></project><project>
<id>1459</id><title_hr><![CDATA[Istraživanje utjecaja na okoliš primjene nanomaterijala u pročišćavanju voda]]></title_hr><title_en><![CDATA[Environmental Implications of the Application of Nanomaterials in Water Purification Technologies]]></title_en><user_id>984</user_id><user_firstLast_name>Hrvoje Kušić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2013-11</proposal_call><code>UIP-2013-11-7900</code><acronim><![CDATA[NanoWaP]]></acronim><duration>20.07.2014 - 19.07.2017</duration><status>Završio</status><financ_value>125.949,23 eur</financ_value><scie_area_hr>Tehničke znanosti, Prirodne znanosti, </scie_area_hr><scie_area_en>Technological sciences, Natural sciences, </scie_area_en><scie_field_hr>Kemijsko inženjerstvo, </scie_field_hr><scie_field_en>Chemical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet kemijskog inženjerstva i tehnologije]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Chemical Engineering and Technology]]></institution_en><team_members_id>1122, 1123, 3191, 3845, 3168, 17765, </team_members_id><team_members_names><![CDATA[Ana Lončarić Božić, Daria Juretić, Dionysios Dionysiou, Urska Lavrencic Stangar, Panaghiotis Karamanis, Marin Kovačić, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[Water treatment, Advanced oxidation technologies, Photocatalysis, Pharmaceuticals degradation, Nanocomposites, Toxicity]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[The water resources globally are facing tremendous pressures due to increased consumption and pollution caused by growing population and industrialization. Thus, the development of advanced treatment technologies is highly required. Technologies using nanomaterials are one of the fast-growing fields creating variety of new commercial nanoparticles. One of the innovative applications of nanomaterials with a great potential involve their usage as water treatment tools. The photocatalytic treatment using nano-TiO2 as a destructive and “zero” waste method for water purification provides a synergy of advanced oxidation technologies and nanomaterials application with a great potential to be commercialized. However, some features of TiO2 photocatalysis, its mechanical and chemical stability, have to be improved to minimize the potential negative implications.The main goal of NanoWaP project is to develop the sustainable photo-AOT with nanocomposite photocatalysts for the purification of water containing pharmaceuticals. In order to overcome the limitations of nano-TiO2 technologies: agglomeration tendency, post-separation, low activation potential under the sunlight, novel nano-TiO2-based composites with iron-exchanged zeolites and SnS2 will be investigated for degradation of pharmaceuticals in water. The efficiency will be evaluated using an innovative integral approach including: (i) pharmaceuticals removal expressed in a terms of common ecological parameters, (ii) energy consumption per decreased concentration of chosen ecological parameter for one order of magnitude, and (iii) the assessment of adverse environmental effects. Besides, the photocatalysts characterization prior and after the treatment would provide an additional insight in its stability which will be also examined through consecutive runs.]]></summary_en></project><project>
<id>1465</id><title_hr><![CDATA[Lokalna proba i mezoskopska dinamika u novim fazama jako koreliranih elektronskih sustava]]></title_hr><title_en><![CDATA[Local Probe and Mesoscopic Dynamics of New Phases in Strongly Correlated Electron Systems]]></title_en><user_id>50</user_id><user_firstLast_name>Miroslav Požek</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2013-11</proposal_call><code>IP-2013-11-2729</code><acronim><![CDATA[LOMEDY]]></acronim><duration>01.09.2014 - 31.08.2018</duration><status>Završio</status><financ_value>125.427,28 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, </scie_field_hr><scie_field_en>Physics, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>3145, 3099, 3159, 3165, 3109, 3116, 17735, 23833, </team_members_id><team_members_names><![CDATA[Antonije Dulčić, Dalibor Paar, Mihael Srđan Grbić, Marko Bosiočić, Damjan Pelc, Tonči Cvitanić, Marija Došlić, Ana Najev, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[nuclear magnetic resonance, microwaves, cuprates, pnictides, frustrated spin systems, charge order]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Investigations of strongly correlated electron systems (SCES) attract an ever-growing scientific community, not only because of high potential for new technological applications, but also as a virtually unfailing source of new basic phenomena and theoretical concepts. The properties of such systems can be described only by taking into account collective phenomena governed by strong and competing interactions, often leading to frustrations. The subtle interplay of interactions is, in turn, a key ingredient for extraordinary complex phase diagrams exhibited by SCES. Even more interesting are regions of instabilities away from stable phases.The way a new phase emerges close to a phase boundary reveals hidden properties of the studied system. It is extremely important to understand how symmetry breaks in the transition itself and identify the space and time-scales relevant for the changes of order parameter within the transition. Sometimes an intermediate state emerges between two stable phases, bringing new physics to light. This project aims to study some of these new, mostly unexplored states that emerge between well explored stable phases in SCES, or as a consequence of some kind of frustration. In order to obtain a complete picture of new states of matter we will combine several advanced experimental methods: nuclear magnetic and quadrupolar resonance (NMR and NQR) as an atomic-scale, local probe, and nonlinear conductivity as a mesoscopic probe of electronic physics. We will be able to systematically study the many phases and transitions in SCES, provide answers to some currently burning questions, and significantly advance our knowledge about them. In particular, we will study charge order in novel superconductors, and spin liquid and spin nematic states in frustrated quantum spin systems.The project will fully employ the new broadband NMR laboratory in Zagreb, strengthen its visibility and international collaborations, and enable finishing of three PhD theses.]]></summary_en></project><project>
<id>1473</id><title_hr><![CDATA[Defolijatori kao invazivni šumski štetnici u uvjetima klimatskih promjena ]]></title_hr><title_en><![CDATA[Defoliators as invasive forest pests in changing climate conditions]]></title_en><user_id>3209</user_id><user_firstLast_name>Milan Pernek</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2013-11</proposal_call><code>IP-2013-11-7616</code><acronim><![CDATA[DIFPEST]]></acronim><duration>16.06.2014 - 15.06.2017</duration><status>Završio</status><financ_value>52.292,79 eur</financ_value><scie_area_hr>Biotehničke znanosti, Prirodne znanosti, </scie_area_hr><scie_area_en>Biotechnical sciences, Natural sciences, </scie_area_en><scie_field_hr>Šumarstvo, </scie_field_hr><scie_field_en>Forestry, </scie_field_en><institution_hr><![CDATA[Hrvatski šumarski institut]]></institution_hr><institution_en><![CDATA[Croatian Forest Research Institute]]></institution_en><team_members_id>868, 2968, 4683, 6691, 6721, 6774, 6993, 17805, </team_members_id><team_members_names><![CDATA[Dinka Matošević, Nikola Lacković, Andreas Linde, Christa Schafellner, Leellen Solter, George Melika, Christian STAUFFER, Ivan Lukić, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[invasive forest pests, climate change, biodiversity, insect pathology, Lymantria dispar, Abraxas pantaria,Cydalima perspectalis]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Climate change, particularly extreme weather events, can directly affect forest pests and the damage they cause by influencing the pests’ development, survival, reproduction and spread and by altering host defences and susceptibility. Basic knowledge of the identity, origin, pathway, and time of introduction of invasive species is essential for assessing the threats. Warming is expected to force species to shift their distributions by expanding into new climatic areas. Several projects have shown that genotypes have increasingly migrated to the north in the last decade, mainly caused by climate change. Records of changes as a result of pest-host-climate change interaction, including possible reasons for changes, are a crucial point of forest monitoring which forms the basis for control strategies and forest management decisions. We will build case studies to represent a specific pest-host-climate change interaction model: native and potentially invasive: i) from one isolated population to other population, (Gypsy Moth); ii) from one climate/geographic region to another (Abraxas pantaria) and non-native potentially invasive in a new climate/geographic region (Cydalima perspectalis). The study presents an extensive research on targeted insect pests in Croatia, taking into account the biology of the pest and host plants and all aspects of the bioecology of the species like genetic constitution and origin, thermal requirements, possible host plants, palatability, influence of antagonists etc.) that influence its spread in a novel environment influenced by climate change and possible serious damage. All the gained data could be used for predictive pest risk analysis models for the researched species, as well as for other native and non-native invasive species that could become a serious threat to Croatian forest ecosystems in changed climate conditions in the near future. ]]></summary_en></project><project>
<id>1478</id><title_hr><![CDATA[GENOMIKA I MOLEKULARNA EPIDEMIOLOGIJA HUMANIH PARAMIKSOVIRUSA U HRVATSKOJ]]></title_hr><title_en><![CDATA[GENOMICS AND MOLECULAR EPIDEMIOLOGY OF HUMAN PARAMYXOVIRUSES IN CROATIA]]></title_en><user_id>936</user_id><user_firstLast_name>DUBRAVKO FORČIĆ</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2013-11</proposal_call><code>IP-2013-11-6255</code><acronim><![CDATA[ParamyxoCro]]></acronim><duration>01.09.2014 - 31.08.2018</duration><status>Završio</status><financ_value>127.015,73 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu]]></institution_hr><institution_en><![CDATA[University of Zagreb]]></institution_en><team_members_id>2510, 3085, 2521, 4279, 4779, 2562, 3357, 3005, 3622, 17817, 23373, </team_members_id><team_members_names><![CDATA[Maja Šantak, Jelena Ivančić Jelečki, Tanja Košutić Gulija, Krešo Bendelja, Goran Tešović, Sunčanica Ljubin-Sternak, Maja Markušić, Ana  Savić Mlakar, Mladen Jergović, Anamarija Slović, Nataša Bauk, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[Paramyxoviruses, molecular evolution, genomics, virus genotype, molecular epidemiology]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[The family Paramyxoviridae harbors a broad spectrum of serious virus pathogens that are of importance to human health and global economics. Paramyxoviruses are RNA viruses with a single-stranded negative sense genome. They have been isolated from a wide variety of species, demonstrating a vast host range and great viral genetic diversity. These ubiquitous pathogens are among the most common causatives of respiratory tract infections and are responsible for a high degree of morbidity and mortality worldwide. The biology of RNA viruses is influenced by their high potential of continuous evolution. Because of the error-prone nature of their RNA-dependent RNA polymerases and large population sizes, RNA viruses show high levels of genetic diversity. Mutations can significantly influence virus biological properties and lead to appearance of new strains. The knowledge of viral evolution depends on the amount of genomic data available for analysis.We propose the research of viral genomics of wild type paramyxoviruses currently circulating in Croatia. It is our goal to increase the number of genetically well characterized paramyxoviral wild-type strains. The proposed work will add to knowledge about paramyxoviral ecology, variability and evolutionary capacities. As molecular epidemiologic monitoring of circulating wild type viruses enables analysis of current relations between existing viral genotypes, it is an invaluable part of virus surveillance and control, facilitating the detection of endemic areas, estimations of vaccine efficacies and predications of possible outbreaks.]]></summary_en></project><project>
<id>1479</id><title_hr><![CDATA[Nano-mreže kvantnih točaka u staklima: Od samouređenja do pretvorbe energije i pohrane vodika]]></title_hr><title_en><![CDATA[Nano-networks of Quantum Dots in Glasses: From Self-assembly to Energy Conversion and Hydrogen Storage]]></title_en><user_id>1362</user_id><user_firstLast_name>Maja Buljan</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2013-11</proposal_call><code>UIP-2013-11-2334</code><acronim><![CDATA[NanoDeSign]]></acronim><duration>01.06.2014 - 31.05.2017</duration><status>Završio</status><financ_value>97.349,99 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, </scie_field_hr><scie_field_en>Physics, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>2755, 3498, 3526, 3509, 3556, 19015, 17815, 21151, </team_members_id><team_members_names><![CDATA[Ivančica Bogdanović Radović, Marko Karlušić, Tihomir Car, Marko Jerčinović, Nikola Radić, Davor Galonja, Nikolina Nekić, Stefano (Antonio) Mezzasalma, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[Quantum dots, Self-assembly, Magnetron sputtering, Quantum dot crystal, Hydrogen storage, Energy conversion, Solar cell, Ion-beam irradiation]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[The main goal of the project is to investigate the capabilities of the recently developed materials based on self-assembled quantum dots organized as nano-networks in glass matrices for application in energy-conversion and Hydrogen-storage devices. Two new self-assembly processes of Ge quantum dots in dielectric amorphous matrices and consequently novel material types have been discovered recently by our group.  We have performed intensive investigation of their structural properties since then, and we had found that they appear in many different shapes, internal structures and ordering types. One material can store large amounts of Hydrogen. However, only properties of Ge and SiGe quantum dots have been investigated, while all other materials and their properties are completely unknown. These materials are theoretically very suitable for applications, especially in photo-electric conversion and energy storage, so the investigations of their properties related to the applications are also very important.We intend to form a group which will be excellent in production, characterization and application of these materials. Precisely, we intend to (i) further investigate the observed self-assembly processes and develop new material types with interesting or extraordinary structural properties; (ii) determine the basic optical and electrical properties of these materials and (iii) produce simple devices based on these materials for energy conversion and storage.We expect preparation of new, applicative materials with exceptional properties, observation of unusual effects caused by specific structure, and preparation of efficient thin-film coatings for conversion and storage of Sun energy. These results could be of great relevance for the production of super-efficient energy-converting window glasses, as the method that we use for the preparation (magnetron sputtering deposition), is a standard technique for production of window coatings and low-emissivity glasses.]]></summary_en></project><project>
<id>1483</id><title_hr><![CDATA[Postupci strojnog učenja za dubinsku analizu složenih struktura podataka]]></title_hr><title_en><![CDATA[Machine learning algorithms for insightful analysis of complex data structures]]></title_en><user_id>4140</user_id><user_firstLast_name>Strahil Ristov</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2013-11</proposal_call><code>IP-2013-11-9623</code><acronim><![CDATA[DescriptiveInduction]]></acronim><duration>16.08.2014 - 15.08.2017</duration><status>Završio</status><financ_value>45.391,20 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Računarstvo, </scie_field_hr><scie_field_en>Computer sciences, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>3806, 3548, 3945, 3822, 4312, 4568, 4718, 17767, 1483, </team_members_id><team_members_names><![CDATA[Tomislav Šmuc, Ivan Michieli, Peter Škoda, Branka Medved Rogina, Nino Antulov-Fantulin, Matija Piškorec, Damir Korenčić, Maria Brbic, Dragan Gamberger, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[machine learning, knowledge discovery, structured data, rule learning, FPGA]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[ Induction is a process of knowledge extraction from information contained in data. In our work we will concentrate on descriptive induction whose goal is to construct knowledge that enables human understanding of the data. Included are techniques for construction of user-interpretable models, segmentation of the corpus of examples, and detection of outliers. The methodology is relevant for the computer science fields known as intelligent data analysis, knowledge discovery from data, and data mining. At Rudjer Boskovic Institute we are developing machine learning algorithms for more than 15 years and we have successfully applied them in various domains including chemistry, biology, medicine, social sciences, economics, and manufacturing. With this project we want to extend the existing methodology and to implement novel techniques able to cope with data contained in complex structures. The main topic will be spatio-temporal structures but we will work also with networks of data, relational databases, and data contained in ontologies. Previous experience clearly demonstrates that complete transformation of information contained in structured data into a form that may enter the induction process is not a simple task. Our goal is to develop and implement systematic and general approaches for this conversion. The consequence will be explosion of generated data that must enter into the process of induction. Therefore, the second goal will be implementation of efficient algorithms for descriptive induction. The work includes development of novel algorithms for clustering and outlier detection in sets of unclassified examples and implementation of hardware for fast execution of rule learning algorithms. The third goal is application and evaluation of implemented algorithms in various real-life domains. The success of the complete project will be measured by the quality and usefulness of knowledge obtained in these applications.]]></summary_en></project><project>
<id>1484</id><title_hr><![CDATA[Bioinspirirani materijali - mehanizmi nastajanja i interakcija]]></title_hr><title_en><![CDATA[Bioinspired Materials - Formation Mechanisms and Interactions]]></title_en><user_id>922</user_id><user_firstLast_name>Damir Kralj</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2013-11</proposal_call><code>IP-2013-11-5055</code><acronim><![CDATA[Bio-Mat-Form]]></acronim><duration>01.10.2014 - 31.01.2019</duration><status>Završio</status><financ_value>118.587,83 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, </scie_field_hr><scie_field_en>Chemistry, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>224, 339, 340, 336, 3922, 3932, 220, 425, 406, 297, 4209, 404, 17878, </team_members_id><team_members_names><![CDATA[Maja Dutour Sikirić, Darija Jurašin, Vlasta Tomašić, Tea Mihelj, Andreja Gajović, Milivoj Plodinec, Jasminka Kontrec, Branka Njegić Džakula, Marko Ukrainczyk, Iva Buljan, Nadica Maltar Strmečki, Vida Čadež, Lara Štajner, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[Biomineralization, Calcium Phosphates, Calcium Carbonates, Precipitation, Model organic molecules]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Prosperity of modern society at large extent relies on the design of new and advanced materials. Many classes of organic, inorganic or hybrid materials are produced by process of precipitation (crystallization) in which the size, morphology, chemical and structural composition could be tuned by the strict control of formation conditions. Process by which living organisms produce hard tissues is known as biomineralization and such tissues are, actually, the organic-inorganic composites. In comparison to their geological analogues, biominerals have the superior mechanical and chemical properties that are a consequence of just a minor presence of extracellular matrix proteins or polysaccharides, as well as of the specific confined environment in which the process occur. In addition, such materials are produced from aqueous systems, chemically neutral precursors, at low temperature and pressure, thus inspiring the scientists investigating the biomimetic syntheses routes for design of functional materials for advanced application.In order to contribute to the understanding of basic interactions between the mineral phases and complex macromolecules, underlying biomineralization, we propose the investigations in which the representative inorganic salts (calcium carbonates & phosphates) will be precipitated in a presence of simple and representative organic molecules (acidic and hydrogen bonding amino acids and custom-designed small peptides) while the complexity of systems will be systematic increased by confining the precipitation in polysaccharide hydrogel or synthetic vesicular microenvironment. Particular attention will be paid on a role of the amorphous and other precursor phases on formation of stable modifications relevant for biomineralization. Besides the precipitation kinetic analyses, the advanced characterization techniques (HR-TEM, EPR, confocal microscopy) will be applied in order to reveal the mechanisms of organic molecules – mineral surface interactions.]]></summary_en></project><project>
<id>1487</id><title_hr><![CDATA[Procjena ponašanja konstrukcija u graničnim uvjetima rada]]></title_hr><title_en><![CDATA[Assessment of structural  behaviour in limit state operating conditions]]></title_en><user_id>3256</user_id><user_firstLast_name>Josip Brnić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2013-11</proposal_call><code>IP-2013-11-6876</code><acronim><![CDATA[STRUBECON]]></acronim><duration>21.07.2014 - 20.07.2018</duration><status>Završio</status><financ_value>128.727,85 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Strojarstvo, </scie_field_hr><scie_field_en>Mechnical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Tehnički fakultet]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Engineering]]></institution_en><team_members_id>3309, 3419, 3329, 3323, 3325, 3328, 3332, 3330, 3318, 17760, </team_members_id><team_members_names><![CDATA[Goran Turkalj, Marko Čanađija, Domagoj Lanc, Marino Brčić, Goran Vukelić, Igor Pešić, Sanjin Kršćanski, Neven Munjas, Edin Merdanović, Damjan Banić, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[structures, material properties, experimental investigations, numerical investigations, limit state, assessment of structural behaviour]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Structures are designed according to their purpose taking into account all relevant service life requirements, which are usually related to a factor of safety, material properties, service life conditions and of course service life prediction. Structure may be sometimes exposed to unexpected conditions, let say adverse or hazard conditions. These conditions may cause failures making structure incapable to perform the function for which it has been designed. The task is to make an assessment of the structure behaviour at mentioned conditions and decide if the structure is capable for further operation. This means the assessment should provide an answer if the structure has sustained irreparable damage. Therefore, the main objective is to provide an assessment of structure behaviour, by comparing of the parameters like stress, strain, crack occurring, etc., caused by certain load level and temperature at this unexpected limit state with those allowed by material properties. To assess structural behaviour in operation at limit state, the following research sub-objectives should be accomplished: testing of material properties for the different environmental conditions; definition of impact energy as well as the determination of the crack driving force and life assessment of structural elements; evaluation of the semi-rigid structural joints/connections behaviour; development of a numerical algorithm for optimization of semi-rigid framed structures; creep buckling simulations of composite beam-type structures; proper constitutive modelling at limit operating conditions (i.e. plasticity, damage, thermomechanical coupling); application of new materials to be used at limit state – nanocomposites. Targeted structures are single and multi storey steel buildings, rigs, high-power electrical transmission towers, ship structures, etc.]]></summary_en></project><project>
<id>1493</id><title_hr><![CDATA[Višeskalno numeričko modeliranje deformiranja materijala od makro do nanorazine]]></title_hr><title_en><![CDATA[Multiscale Numerical Modeling of Material Deformation Responses from Macro- to Nanolevel]]></title_en><user_id>927</user_id><user_firstLast_name>Jurica Sorić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2013-11</proposal_call><code>IP-2013-11-2516</code><acronim><![CDATA[MNumMacroNano]]></acronim><duration>15.07.2014 - 14.07.2018</duration><status>Završio</status><financ_value>127.376,63 eur</financ_value><scie_area_hr>Tehničke znanosti, Biotehničke znanosti, Prirodne znanosti, </scie_area_hr><scie_area_en>Technological sciences, Biotechnical sciences, Natural sciences, </scie_area_en><scie_field_hr>Temeljne tehničke znanosti, </scie_field_hr><scie_field_en>Basic engineering sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet strojarstva i brodogradnje]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Mechanical Engineering and Naval Architecture]]></institution_en><team_members_id>1010, 1039, 1028, 2803, 1012, 3311, 285, 17578, 17579, 21241, 21256, 21254, </team_members_id><team_members_names><![CDATA[Igor Karšaj, Ivica Skozrit, Boris Jalušić, Tomislav Lesičar, Lana Virag, Zdenko Tonković, Robert Pezer, Filip Putar, Ivan Trapić, Karlo Seleš, Christian Weißenfels, Joško Frančeski, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[Engineering materials, bilogical tissues, multiscale modeling, finite element  method, meshless method, damage modeling, molecular dynamics]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Many engineering materials as well as biological tissues have a heterogeneous structure particularly when they are observed at microlevel. In order to assess structural integrity as well as to predict structural lifetime, an analysis at microlevel is required. In recent years, a special attention has been directed to the investigation of relations between macroscopic properties of materials and their microstructure as well as to perform a link to atomistic scale. Since classical continuum mechanics cannot consider structural effects in the material at the micro- and nanolevel, multiscale techniques are developed that model material deformation responses at multiple levels using appropriate numerical procedures. Deformation responses of arteries will be considered by using multiscale computational strategy too. A special attention will be directed toward the mathematical modeling of arterial growth and remodeling, which could help physicians to track certain cardiovascular diseases and predict their development. For modeling of engineering materials, a new micro-macro numerical procedure based on the second-order computational homogenization approach employing nonlocal continuum theory will be proposed. Both finite element and meshless spatial discretization will be applied. The damage evaluation at the microlevel which may lead to macroscopic fracture will be modeled. Here the damage evaluation law based on the computational averaging procedure will be used and the modeling at atomistic scale will be performed in the very narrow domain of localization. In the atomistic modeling using molecular dynamics, a special attention will be directed to the coupling of atomistic domain with the discretized continuum domain. An approach inspired by the quasicontinuum and bridging domain will be proposed. All results of the research will be tested by the modeling deformation responses of realistic materials.]]></summary_en></project><project>
<id>1497</id><title_hr><![CDATA[Djelovanje progesterona u reproduktivnim i ne-reproduktivnim tkivima]]></title_hr><title_en><![CDATA[Progesterone action in reproductive and non-reproductive tissues]]></title_en><user_id>1286</user_id><user_firstLast_name>Biserka Mulac-Jeričević</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2013-11</proposal_call><code>IP-2013-11-3432</code><acronim><![CDATA[reproduction2013]]></acronim><duration>01.09.2014 - 30.11.2018</duration><status>Završio</status><financ_value>132.191,92 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Javno zdravstvo i zdravstvena zaštita, </scie_field_hr><scie_field_en>Public health and health services, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Medicine]]></institution_en><team_members_id>3456, 3448, 3361, 3467, 5756, 4733, 5775, </team_members_id><team_members_names><![CDATA[Sandra Šućurović, Zdravko Jotanović, Jagoda Ravlić-Gulan, Gordan Gulan, Jan Brosens, Neda Smiljan Severinski, Hrvoje Jakovac, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[Progesterone, progesterone receptors, uterus, bone, physiology, pathophysiology, animal model, human]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Progesterone (P) is an indispensable regulator of female reproductive function, but also has an important role in non-reproductive tissues. Aberrant P signaling has been associated with reproductive conditions, cancer, metabolic disorders, cardiovascular defects, and neurological defects. In humans and mice the physiological effects of P are mediated by two intracellular receptors, termed PR-A and PR-B, expressed in subset of cells in target tissues. PR-A and PR-B isoforms are transcribed from a single gene by alternative promoter usage. PR-A (94 kD) isoform differ from PR-B (120 kD) by lacking 164 amino acids at the N terminus . Analyses to date have shown that PR-A and PR-B mediate mostly distinct but partially overlapping reproductive tissue selective physiological responses to P. The overall objective of this research is to establish the selective physiological roles of each of the individual PR isoforms in their natural physiological context. For this research we will use a genetically modified mouse in which gene targeting was used to knockout expression of either the PR-A or PR-B isoform in mice. The specific aims of this application are as follows: 1. To examine the isoform-selective molecular mechanisms by which PR-A and PR-B differentially regulate uterine epithelial proliferation, uterine receptivity and stromal decidualization. 2. To examine the selective contributions of the PR-A and PR-B isoforms to the P dependent immunomodulatory activity during early pregnancy. 3. To identify progesterone-regulated genes in musculoskeletal tissue using a genetically altered mouse models lacking progesterone receptors. 4. To determine whether differential signaling pathways of PR isoforms are conserved from rodent to human. It is expected that this research will contribute to understanding the molecular mechanisms of P in reproductive tissues and musculoskeletal and could lead to new strategies for disease prevention and treatment.]]></summary_en></project><project>
<id>1503</id><title_hr><![CDATA[Genetika i fiziologija tolerancije na višestruki stres kod kukuruza]]></title_hr><title_en><![CDATA[Genetics and physiology of multiple stress tolerance in maize]]></title_en><user_id>3305</user_id><user_firstLast_name>Domagoj Šimić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2013-11</proposal_call><code>IP-2013-11-5707</code><acronim><![CDATA[MUST-MAIZE]]></acronim><duration>16.06.2014 - 15.06.2018</duration><status>Završio</status><financ_value>107.505,47 eur</financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Poljoprivreda, </scie_field_hr><scie_field_en>Agriculture, </scie_field_en><institution_hr><![CDATA[Poljoprivredni institut Osijek]]></institution_hr><institution_en><![CDATA[Agricultural Institute Osijek]]></institution_en><team_members_id>4241, 4812, 5221, 5133, 3283, 6391, 4899, 6193, 4907, 3281, 2824, 6447, 17788, </team_members_id><team_members_names><![CDATA[Mario Franić, Antun Jambrović, Tatjana Ledenčan, Luka Andrić, Maja Mazur, Vera  Cesar, Josip B rkić, Lidija Begović, Zvonimir Zdunić, Andrija Brkić, Jasenka Antunović, Ivan Brkić, Vlatko Galić, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[drought, diabrotica, plant density, cadmium excess, genomic selection]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Plant responses to different stresses are highly complex and involve changes at the genetic and physiological levels. Maize as a major crop worldwide is essential for industry and is cultivated mostly in rain-fed cropping systems where changes in climate or diminishing water supply take place. Grain yield, the most important trait in maize as a composite trait is influenced by many stress-related traits. The main goal of this project is to elucidate and integrate common genetic and physiological mechanisms underlying the multiple-stress tolerance in maize. The specific aims are to detect genetic and physiological factors responsible for plant response to high plant density, drought, Diabrotica and Fusarium attacks as well as cadmium excess in soil in testcrosses of two maize populations (reference IBM population and a doubled haploid population) and their respective parents. By investigating root and leaf characteristics including chlorophyll fluorescence and other stress parameters as reliable indicators of stress in four-year field and pot experiments conducted in Croatia and Turkey, DNA marker-assisted selection and genomic selection could accelerate maize breeding for yield, abiotic and biotic stress tolerance. A multidisciplinary approach, which ties together breeding, physiology and molecular genetics, can bring a synergistic understanding to the response of maize to multiple stresses.]]></summary_en></project><project>
<id>1513</id><title_hr><![CDATA[Povijesne perspektive transnacionalne prakse i međukulturnog dijaloga u Austro-Ugarskoj monarhiji]]></title_hr><title_en><![CDATA[Historical Perspectives on Transnationalism and Intercultural Dialogue in the  Austro-Hungarian Empire]]></title_en><user_id>1018</user_id><user_firstLast_name>Anita Sujoldžić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2013-11</proposal_call><code>IP-2013-11-3914</code><acronim><![CDATA[TIDA]]></acronim><duration>01.09.2014 - 31.08.2018</duration><status>Završio</status><financ_value>73.608,07 eur</financ_value><scie_area_hr>Humanističke znanosti, Društvene znanosti, </scie_area_hr><scie_area_en>Humanities, Social sciences, </scie_area_en><scie_field_hr>Etnologija i antropologija, </scie_field_hr><scie_field_en>Ethnology and anthropology, </scie_field_en><institution_hr><![CDATA[Institut za antropologiju]]></institution_hr><institution_en><![CDATA[Institute for Anthropological Research]]></institution_en><team_members_id>2965, 3447, 1284, 4784, 1524, 3749, 2753, 20152, 3395, </team_members_id><team_members_names><![CDATA[Zrinjka Glovacki-Bernardi, Gottsmann Andreas, Olga Orlić, Stefan Wedrac, Mirna Jernej Pulić, Anja Ivekovic Martinis, Marina Rončević, Duga Mavrinac, Krešimir Sučević-Međeral, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[multilingualism, transnational, intercultural, communication, hybridity, legacy]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[This interdisciplinary project aims to provide a new way of learning from the past about strategies used in the South-Eastern part of the Austro-Hungarian Empire to overcome social tensions as a potential legacy of intercultural dialogue in the present European context. It will explore how in  the multilingual imperial space of intensive cultural exchange and economic mobility the interethnic and social tensions were shaped by (trans)-intercultural communication and practices, both from above and from below. It focuses on accounts of plural belongings and hybrid identities that are geographically grounded, socio-economically situated and embedded in cultural and linguistic practices manifested by multilingualism  and intercultural competence of social scripts and behaviour.The project will cover spatially and regionally confined patterns of interaction in the Croatian part of Istria, and the cities of Pula and Zadar under direct Habsburg influence and in the cities of Rijeka and Zagreb, politically bound to the Hungarian part of the Empire during the period 1870-1918. The main strains of research will focus on uncovering discourses produced through three social spaces, those of institutions (administration and education), associations (cultural, sport), and those visible in everyday life, through consumption practices and tourism. The analyses will encompass social practices in different domains of life, symbolic system (focusing on language) and the use of artifacts, or material life. The specific objective is to provide a contrastive reading of Austro-German, Italian and Slavic sources illuminating both the established discourses of knowledge production, emanating from imperial centres of Vienna and Budapest, and the counter-discourses, and their reception by common people in the periphery.]]></summary_en></project><project>
<id>1516</id><title_hr><![CDATA[Pravni status i stvarni položaj osoba s duševnim smentnjama - interdisciplinarni pristup i europske perspektive]]></title_hr><title_en><![CDATA[Legal Status and Real Position of People with Mental Difficulties – Interdisciplinary Approach and European Perspectives]]></title_en><user_id>597</user_id><user_firstLast_name>Velinka Grozdanić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2013-11</proposal_call><code>IP-2013-11-2287</code><acronim><![CDATA[LSRPPMDIAEP]]></acronim><duration>01.03.2015 - 28.02.2018</duration><status>Završio</status><financ_value>19.389,77 eur</financ_value><scie_area_hr>Društvene znanosti, Biomedicina i zdravstvo, </scie_area_hr><scie_area_en>Social sciences, Biomedicine and health sciences, </scie_area_en><scie_field_hr>Pravo, </scie_field_hr><scie_field_en>Law, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Pravni fakultet]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Law]]></institution_en><team_members_id>3337, 2985, 7306, 2901, 4639, 2875, 3315, 19033, </team_members_id><team_members_names><![CDATA[Miroslav Goreta, Vesna  Šendula Jengić, Zoran Kanduč, Kristijan  Grđan, Marissabell Škorić, Dalida Rittossa, Igor Martinović, Dražen Tripalo, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[people with mental disorders, legal status, actual position, interdisciplinary perspective, European standards  ]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[In last two years the European Court for Human Rights assessed three major cases involving rights of persons with mental disorders in the Republic of Croatia (Đorđević v. Croatia, M.S. v. Croatia and A.K. and L. v. Croatia). The Court concluded that current legal regulations and practice governing the prevention of violence against mentally disabled persons, their power to instigate criminal proceedings without explicit guardian&#39;s consent and divestment of parental rights have violated the Article 3 and 8 of the Convention of Human Rights and Fundamental Freedoms. Court decisions present a clear warning that rights of people with mental difficulties have not been adequately protected in Croatia and that there is a need for substantial reform of the laws regulating their legal status. Bearing this in mind, the Project is designed to critically analyse current legal regulations in the light of already accepted high international standards and to conduct empirical research at four county courts with the widest jurisdiction in order to evaluate whether the regulations are adequately applied in practice. Analytical and empirical results will be used as a valid basis to create a new Bill on Protection of Persons with Mental Difficulties as the main legal instrument to regulating the legal status of this especially vulnerable group. In order to facilitate application of the new Law in practice and to make a concrete impact on real position of people with mental health issues, the project will seek to organise seminars, round table discussions and workshops for mental health lawyers and psychiatrists. By its in-depth research approach in interdisciplinary settings, the ultimate Project goal is to improve and promote rights of people with mental disability and increase their empowerment, enabling them to enjoy full citizenship on an equal basis with other members of Croatian society.]]></summary_en></project><project>
<id>1518</id><title_hr><![CDATA[Standardizacija i primjenjena istraživanja kvartarnih sedimenata Hrvatske]]></title_hr><title_en><![CDATA[STANDARDISATION AND APPLYED INVESTIGATION OF QUATERNARY SEDIMENTS IN CROATIA]]></title_en><user_id>3320</user_id><user_firstLast_name>Lidija Galović</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2013-11</proposal_call><code>UIP-2013-11-4425</code><acronim><![CDATA[SAPIQ]]></acronim><duration>01.09.2014 - 31.12.2017</duration><status>Završio</status><financ_value>129.811,14 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Geologija, </scie_field_hr><scie_field_en>Geology, </scie_field_en><institution_hr><![CDATA[Hrvatski geološki institut]]></institution_hr><institution_en><![CDATA[Croatian Geological Survey]]></institution_en><team_members_id>3963, 4030, 4262, 3950, 3511, 3956, 165, 4536, 7107, 20279, 20272, 20205, </team_members_id><team_members_names><![CDATA[Lara Wacha, Adriano Banak, Anita Grizelj, Hrvoje Posilović, Koraljka Bakrač, Danijel Ivanišević, Jadranka Mauch Lenardić, Manfred Frechen, Petar Stejic, Rodoljub Gajić, Mihajlo Pandurov, MARSCHE INGEBORG Soulie-Marsche , ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[Quaternary, litostratigraphical unites, Croatia, spatial distribution, climate proxies]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Quaternary sediments in Croatia cover about 40% of the surface and have hence an important role in the economy of the country. Achieved models and tools for investigation enable wider application of results in economy. Furthermore, Quaternary deposits are direct results of ancient climatic conditions and hence understanding them can help interpreting and predicting actual events. The goal of this Installation Research Project is to establish a group of researchers in the Croatian Geological Survey (CGS), Department of Geology, to additionally equip and train them, so they could standardise and carry out their research of Quaternary sediments of Croatia applying new analytical techniques and new scientific findings. Those new compositional data will enable correlating our results with the EU, especially for the middle and south Europe. In this project we would like to deal with Quaternary sediments on the both regions: Pannonian and Dinaric. During the first year we plan to get know new equipment, methodology and to investigate all the different types of Quaternary sediments in Croatia. In the second and third year plan is to scrutinize the sediments in selected area in the each region (Pannonian and Dinaric).The strategic importance of Quaternary sediments for Croatia is based partly on the agricultural utilization of the Holocene soils developed on these deposits and partly as a collector of drinking water, reflecting to the whole biosphere. Furthermore, the hydrogeological properties of separate horizons of Quaternary sediments are different, so, insight in the structures of sediment layers could lead to finding new water resources.]]></summary_en></project><project>
<id>1526</id><title_hr><![CDATA[Razvoj višenamjenskog sustava upravljanja zemljištem]]></title_hr><title_en><![CDATA[Development of Multipurpose Land Administration System]]></title_en><user_id>426</user_id><user_firstLast_name>Miodrag Roić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2013-11</proposal_call><code>IP-2013-11-7714</code><acronim><![CDATA[DEMLAS]]></acronim><duration>01.09.2014 - 31.08.2018</duration><status>Završio</status><financ_value>122.469,97 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Geodezija, </scie_field_hr><scie_field_en>Geodesy, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Geodetski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Geodesy]]></institution_en><team_members_id>5698, 3172, 3563, 3628, 3704, 3304, 3205, 837, 3180, 3060, 4353, 3245, 3065, 3889, 4200, 4197, 3758, 3356, 3629, 3725, 4349, 4189, 5610, 6782, 21294, 21295, </team_members_id><team_members_names><![CDATA[Siniša Mastelić Ivić, Vlado Cetl, Rinaldo Paar, Dražen Tutić, Hrvoje Matijević, Ante Marendić, Loris Redovniković, Hrvoje Tomić, Mario Mađer, Baldo Stančić, Iva Ališić, Goran Jurakić, Saša Vranić, Boris Blagonić, Irena Benasić, Veljko Flego, Blaženka Mičević, Nikola Vučić, Darko Šiško, Jelena Jurišić, Tiana Pribanić, Marijan Ratkajec, Frančesko Duboković, Miroslav Kuburić, Dragan Divjak, Igor Grgac, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[Land Administration System, Land Registers, Land Management, Sustainable Development, Geoinformation]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[The primary purpose of a land administration system (LAS) is the registration of legal or other formal relations of persons to land. Besides its primary purpose, land administration system can and should also serve as a basis for land management. Different to the land administration, land management is a set of processes ensuring that the land is used in an efficient and sustainable manner. Unfortunately, land administration systems are rarely able to fulfill such additional requirements, even in the developed countries.This project aims at finding what needs to be done in order to transform a traditional land administration system into a modern multipurpose land administration system (MLAS), which can efficiently support land management. Our hypothesis says that such a transformation can be done by improving two aspects of a LAS, its efficiency and its usability.Under efficiency we consider the ability of a LAS to update its data quickly whilst ensuring the consistency and correctness thereof. Within the project we will investigate options for outsourcing the preparation of transactions to private sector and the possibilities to more efficiently collect field data within the improved process of updating LAS data.Even more important that its efficiency, is the usability of a LAS. This is the second aspect that we try to improve within the project. Besides the mere registration of the land, MLAS must be able to efficiently support processes of land valuation, urban planning and various rearrangements aiming to increase agricultural productivity of the land. Within the project we will investigate which additional data needs to be collected, processed and stored within the LAS in order to enable efficient support to land management processes.As a starting point for the research we use our previous research closely related to the topics of land administration and land management, and the Land Administration Domain Model (LADM), which recently became the ISO standard.]]></summary_en></project><project>
<id>1528</id><title_hr><![CDATA[Repozitorij metafora hrvatskoga jezika]]></title_hr><title_en><![CDATA[Croatian Metaphor Repository]]></title_en><user_id>3388</user_id><user_firstLast_name>Kristina Štrkalj Despot</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2013-11</proposal_call><code>UIP-2013-11-3624</code><acronim><![CDATA[Meta4Cro]]></acronim><duration>01.09.2014 - 31.08.2017</duration><status>Završio</status><financ_value>74.324,77 eur</financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Filologija, </scie_field_hr><scie_field_en>Philology, </scie_field_en><institution_hr><![CDATA[Institut za hrvatski jezik]]></institution_hr><institution_en><![CDATA[Institute of Croatian Language]]></institution_en><team_members_id>4388, 4516, 2966, 4665, 5556, </team_members_id><team_members_names><![CDATA[Benedikt Perak, Mirjana Tonković, Bruno Nahod, Mario Essert, Mario Brdar, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[conceptual metaphor, image schemas, frames, metonymy, metaphor in natural language processing and artificial intelligence]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[The Croatian Metaphor Repository project will involve: theoretical research of conceptual metaphor, metonymy, image schemas and frames in the Croatian language from a synchronic and diachronic perspective; computational linguistic research on metaphor in natural language processing and artificial intelligence involving developing tools for semi-automatic metaphor detection and semi-automatic extraction of linguistic metaphors; psychological experiments to further explain the nature of the links between concept meaning and perception as manifested through primary metaphors. The applied goal of the project is to create a metaphorical language database ? the Croatian Metaphor Repository. The database will be available on the Internet. It will include the following levels: conceptual metaphors, linguistic metaphors, image schemas, cogs and frames. Metaphors will be divided by type (primary, complex and entailed metaphors), by level (general, specific), and by family (Event Structure Metaphors, Mind Metaphors, Morality Metaphors, Scalar Metaphors, Time Metaphors, Emotion Metaphors, Economics Metaphors, Governance Metaphors, Cascade Metaphors, Well-being Metaphors etc.). The theoretical background for the linguistic analysis of conceptual metaphors is the Neural Theory of Language and Thought and the Neural Theory of Metaphor. Formal annotation tools are taken from embodied construction grammar. Both theoretical research and the creation of the repository will significantly advance Croatian cognitive and computational linguistics, artificial intelligence studies and the research of language and learning processes. The database will allow for generalizations and will become a very useful tool for cross-linguistic and cross-cultural research of metaphor and thought leading to further development of the theory and the field and to understanding how people learn, understand, and use language. The project has significant potential for further international development.]]></summary_en></project><project>
<id>1531</id><title_hr><![CDATA[Kodovi i s njima povezane kombinatoričke strukture]]></title_hr><title_en><![CDATA[Codes and Related Combinatorial Structures]]></title_en><user_id>885</user_id><user_firstLast_name>Dean Crnković</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2013-11</proposal_call><code>IP-2013-11-1637</code><acronim><![CDATA[CoCoS]]></acronim><duration>01.07.2014 - 30.06.2018</duration><status>Završio</status><financ_value>114.972,04 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Matematika, </scie_field_hr><scie_field_en>Mathematics, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Fakultet za matematiku]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Mathematics]]></institution_en><team_members_id>919, 907, 5381, 5935, 4515, 4484, 4992, 841, 1089, 3161, 3906, 3468, 3226, 5384, 17780, 20561, </team_members_id><team_members_names><![CDATA[Sanja Rukavina, Vedrana Mikulić Crnković, Mario Osvin Pavčević, Vedran Krčadinac, Andrea Švob, Anamari Nakić, Kristijan Tabak, Loredana Simčić, Doris Dumičić, Marija Maksimović, Ana Grbac, Nina Mostarac, Marina Šimac, Sanja Vranić, Renata Vlahović, Ronan Egan, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[code, network coding, t-design, q-ary design, graph, strongly regular graph, finite group]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[The project will deal with construction of codes and combinatorial structures, such as combinatorial designs, designs over finite fields (q-ary designs), difference sets and various types of graphs, for example strongly regular graphs and divisible design graphs. Beside linear codes over finite fields and finite rings, we will also investigate quantum codes and network codes. In fact, the links and connections between codes and combinatorial structures are the main focus and emphasis of the proposed project. For constructions of the combinatorial structures and codes we will mainly use algebraic, geometric and enumerative techniques, as well as computational methods. When dealing with combinatorial structures, these include in particular constructions from finite groups and constructions using orbit matrices. The very general Kramer-Mesner method will be implemented and combined with other methods like that of tactical decompositions. Codes will be constructed directly from the obtained combinatorial structures, and vice versa. Our research in scope of this project will also include constructions of Hadamard matrices and related designs and codes. All gotten structures will be analyzed in terms of their automorphism groups and other structural (geometric, algebraic) properties. Obtained codes, designs and graphs will be compared with the previously known structures. As a result of the proposed research, we expect constructions of codes with good properties, possibly better than the presently known codes, and constructions and classifications of various combinatorial structures.]]></summary_en></project><project>
<id>1535</id><title_hr><![CDATA[Upravljanje vodom i toplinom i trajnost membranskih gorivnih članaka]]></title_hr><title_en><![CDATA[Water and Heat Management and Durability of PEM Fuel Cells]]></title_en><user_id>1118</user_id><user_firstLast_name>Frano Barbir</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2013-11</proposal_call><code>IP-2013-11-8700</code><acronim><![CDATA[PEMFUELCELL]]></acronim><duration>01.01.2015 - 30.06.2018</duration><status>Završio</status><financ_value>106.427,77 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Strojarstvo, </scie_field_hr><scie_field_en>Mechnical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Splitu, Fakultet elektrotehnike, strojarstva i brodogradnje]]></institution_hr><institution_en><![CDATA[University of Split, Faculty of Electrical Engineering, Mechanical Engineering and Naval Architecture]]></institution_en><team_members_id>3668, 4330, 3698, 4347, 4058, 97, 4479, 17740, 18920, </team_members_id><team_members_names><![CDATA[Ivan Tolj, Dario Bezmalinović, Gojmir Radica, Gojko Magazinović, Jagoda Radošević, Ante Bilušić, Paško Županović, Ivan Pivac, Željko Penga, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[PEM fuel cell,  temperature control, humidity of reactant gases, durability stressors, decay mechanisms]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[The subject of the proposed research and development are the fuel cells – devices for direct electrochemical conversion of fuel (usually hydrogen) into electricity, with many potential applications, from propulsion of vehicles to mobile and stationary power generation at different scales (from mW to MW). This project will investigate a possibility to design and operate a Polymer Electrolyte Membrane (PEM) fuel cell with ambient air without external humidification using water and heat produced inside the fuel cell. This may be accomplished with adequate temperature distribution along the cathode channel, which would require a specific design of the fuel cell in terms of spatially variable heat transfer rates, and corresponding control of the cooling subsystem. In order to determine whether the proposed concept would result in longer life of fuel cell, some basic understanding of causes of fuel cell degradation is needed, particularly related to water and heat management. Particularly, it is proposed to investigate heat transfer in nano-structured catalyst layer because inadequate heat removal from the electrochemical reaction sites may be one of the causes for fuel cell degradation. Other stressors will be studied as well, and procedures for accelerated durability testing will be established, in order to confirm that the proposed concept of  water and heat management is beneficial to fuel cell durability.The proposed research is expected to improve understanding of water and heat transfer in PEM fuel cell, including the effects that dry conditions and inadequate heat removal from the catalyst sites may have on fuel cell durability. This novel concept of variable temperature along the cathode channel would result in simplification of the fuel cell support system by eliminating the devices needed for external humidification, without affecting fuel cell performance and durability in various applications.]]></summary_en></project><project>
<id>1540</id><title_hr><![CDATA[Hrvatska i Srednja Europa: umjetnost i politika u razdoblju moderne (1780. - 1945.)]]></title_hr><title_en><![CDATA[Croatia and Central Europe: Art and Politics in the Late Modern Period (1780-1945)]]></title_en><user_id>3499</user_id><user_firstLast_name>Dragan Damjanović</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2013-11</proposal_call><code>UIP-2013-11-4153</code><acronim><![CDATA[CroCE-ArtPolitics]]></acronim><duration>15.06.2014 - 14.06.2017</duration><status>Završio</status><financ_value>74.590,22 eur</financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Povijest umjetnosti, </scie_field_hr><scie_field_en>Art history, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Filozofski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Humanities and Social Sciences]]></institution_en><team_members_id>4143, 4151, 4195, 4206, 4237, 4446, 4475, 4459, 4416, 4794, 4554, </team_members_id><team_members_names><![CDATA[Željka Miklošević, Nadežda Čačinovič, Zvonko Maković, Sandi Bulimbašić, Daniel Zec, Lovorka Magaš Bilandžić, Sanja  Zadro, Iskra Iveljić, Silvija Lučevnjak, Frano Dulibić, Jasminka Najcer Sabljak, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[Croatia, Central Europe, 19th Century Art, 20th Century Art, Modernism, Sociopolitical Context, Art Discourses, Visual Communication, Popular Culture]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[The main aim of the project Croatia and Central Europe: Art and Politics in the Late Modern Period (1780-1945), is to get a comprehensive insight on the basis of fundamental research into relationships between art and political regimes seen from various perspectives and based on different discourses (governmental, social, economic, religious, gender, ethnic and the like) in the given area which has a common political and sociocultural background. The project spans the period from the 1780s, which was marked by great changes in the Hapsburg Monarchy during the reign of Joseph II, to the end of the Second World War when political circumstances brought an end to the integrity of Central Europe. The project has been conceived as a broad-based research of fine and applied arts (painting, sculpture, architecture, graphic arts, photography, comics, cartoons, etc.) through multidisciplinary and interdisciplinary approaches using methods pertaining to humanities and social sciences. Research will comprise topics relating to (mis)use of art for or against political regimes, artistic heritage of marginalized groups, the concept of unwanted heritage and institutional construction of art discourses and their reception. Understanding sociopolitical background can contribute to greater understanding of heritage-based conflicts, while indications of the transnational nature of Central European art can encourage its protection and ensure its sustainability. The research team, headed by an assistant professor from the Faculty of Humanities and Social Sciences, University of Zagreb, consists of academic researchers, doctoral candidates, and professionals from museums and monument protection institutes. Expected results and outcomes of the project include publications on the given topics, a more profound scientific knowledge about art developments within sociopolitical contexts and future collaboration with foreign researchers.]]></summary_en></project><project>
<id>1543</id><title_hr><![CDATA[Utjecaj okolišnog stresa na pojavnost i međudjelovanje biološki važnih organskih molekula i mikronutrijenata u morskom ekosustavu]]></title_hr><title_en><![CDATA[Appearance and interaction of biologically important organic molecules and micronutrient metals in marine ecosystem under environmental stress]]></title_en><user_id>81</user_id><user_firstLast_name>Blaženka Gašparović</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2013-11</proposal_call><code>IP-2013-11-8607</code><acronim><![CDATA[AMBIOMERES]]></acronim><duration>01.10.2014 - 31.01.2019</duration><status>Završio</status><financ_value>110.292,65 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, </scie_field_hr><scie_field_en>Chemistry, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>101, 75, 120, 84, 362, 106, 691, 85, 17849, </team_members_id><team_members_names><![CDATA[Marina  Mlakar, Marta Plavšić, Vlado Cuculić, Sanja Frka Milosavljević, Snježana Kazazić, Slađana Strmečki Kos, Petra Vukosav, Abra Penezić, Tihana Sesar, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[organic matter, lipids, acidic polysaccharides, micronutrient metals, oligotrophy, eutrophy, monocultures, field work]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Recently documented oligotrophication of the Adriatic Sea caused by global changes opened questions how this reflects on the quality and quantity of organic matter (OM) produced by the phytoplankton and on the consequent influence on the micronutrient metals availability and cycling. Within the project, a progressive (model and in-situ) approach will be accomplished to reveal crucial alterations in the marine ecosystem. Initial investigations will imply model experiments on the interaction of selected OM (polysaccharides, lipids, polymeric organic matter containing N catalytic atoms) with micronutrient metals (Fe, Co, Cu, Zn and Cd). Additionally, phytoplankton monoculture incubation under various growth conditions (nutrient concentrations and temperature variations) will be included in order to comprehend multiple impacts on the phytoplankton OM production and micronutrients metals distribution. Model experiments will be followed by in-situ investigations at the selected oligotrophic and eutrophic areas of the Adriatic Sea. This will give holistic informations on the natural marine biochemical cycles and linkage between OM and micronutrient metals. In-situ investigations will be focused on the seasonal variations of the OM and micronutrient appearance and concentrations in combination with physico-chemical parameters (temperature, salinity, pH, O2), and dissolved and particulate organic carbon content, surface-active organic substances and macronutrients (PO4, NO3, NO2, NH4). These investigations will be assessed by intercomparable and multimethodological approaches using various chromatographic to electrochemical techniques. Finally, taking into account all obtained results an important part of the natural marine ecosystem processes will be characterized in the prospective of climate changes.]]></summary_en></project><project>
<id>1551</id><title_hr><![CDATA[Što se zbiva u sjevernom Jadranu? - Klimatske promjene, acidifikacija, bioraznolokost, eutrofikacija. - Nove tehnologije]]></title_hr><title_en><![CDATA[What Works Within northern Adriatic? – Climatic changes, Acidification, Biodiversity, Eutrophication. - New Enhanced Technology]]></title_en><user_id>3596</user_id><user_firstLast_name>Robert Precali</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2013-11</proposal_call><code>IP-2013-11-8541</code><acronim><![CDATA[www.NA-CABE.net]]></acronim><duration>01.10.2014 - 30.09.2018</duration><status>Prekinut</status><financ_value>0,00 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Biologija, </scie_field_hr><scie_field_en>Biology, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>429, 318, 465, 467, 468, 451, 473, 4424, 3992, </team_members_id><team_members_names><![CDATA[Romina Kraus, Tina Šilović, Ingrid Ivančić, Tamara Đakovac, Nastenjka Supić, Jelena Godrijan, Paolo Paliaga, Daniela Maric Pfannkuchen, Jakica Njire, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[northern Adriatic, climatic changes, acidification, biodiversity, eutrophication]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[The northern Adriatic (NA) seems to be strongly influenced by the anthropogenic drivers - climatic changes, acidification and eutrophication. Its semi-enclosed nature, characterised by smaller inertia - due to the relative short residence time of its water masses, makes it highly reactive to the external forcing, in particular to the variations of the water, energy and matter fluxes at the interfaces. The NA, identified as a Mediterranean&#39;s climatic change „hotspot“, is expected to withstand environmental impacts that are considerably greater than in many other places worldwide. Such a uniquely dynamic system allows as to investigate the biological capacity and ecosystem elasticity in relation to these forcings. This project, at this state of knowledge, will be the first one that tries addressing the impact of the aforementioned anthropogenic drivers on the ecosystem behaviour (changes in water chemistry, metabolic activity and biodiversity). It will also advance the international state of the art in the following aspects: temporal resolution of the in situ acidification and phytoplankton physiology analysis, taxonomic resolution, combined taxonomic and metabolic analyses and molecular biodiversity.A buoy positioned at a point that integrates the most of the NA dynamics will serve as a hub for the continuous acquisition of the oceanographic and biological parameters. Together with the largest historical data set in the wider area and the most advanced approaches (in situ pH and phytoplankton physiology, taxonomy and analyses of metabolic activities), it will allow us an exhaustive insight in these interactions. At the end, this research will enable us to build scenarios of possible ecosystem reactions to predicted environmental changes in the NA and, in a wider sense, to all marine systems.]]></summary_en></project><project>
<id>1557</id><title_hr><![CDATA[Cjelogenomska analiza povezanosti Hashimotovog tiroiditisa]]></title_hr><title_en><![CDATA[Genome-wide association analysis of Hashimoto thyroiditis]]></title_en><user_id>63</user_id><user_firstLast_name>Vesna Boraska</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2013-11</proposal_call><code>UIP-2013-11-4950</code><acronim><![CDATA[HashimotoGWAS]]></acronim><duration>15.09.2014 - 14.01.2018</duration><status>Završio</status><financ_value>132.722,81 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Splitu, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Split School of Medicine]]></institution_en><team_members_id>118, 137, 3571, 388, 260, 611, 4749, 1067, 17744, 19036, 1113, </team_members_id><team_members_names><![CDATA[Tatijana Zemunik, Maja Barbalić, Ante Punda, Sanda Gračan, ANA BARIĆ, Vesela Torlak, Stana Tokić, Eleftheria Zeggini, Luka Brčić, Ivana Gunjača, Veselin Škrabić, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[Hashimoto thyroiditis, thyroid gland, genome-wide association analysis (GWAS), statistical genetics, single nucleotide polymorphism (SNP), biobank]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Autoimmune thyroid diseases (AITD) are very common and affect 2-5% of the general population. The most frequent form of AITD is Hashimoto thyroiditis (HT) that is characterised by progressive destruction of thyroid tissue. Many studies tried to unravel genetic contribution to HT development in the past few decades but with low success. The breakthrough of the genome-wide association studies (GWAS) tremendously increased the rate of detecting novel associations. However, HT has been unrepresented in the GWAS mostly because of the lack of large cohorts of HT patients and the performance of such study is a matter of urgency. We plan to recruit 500 HT patients and to create a DNA/serum/plasma biobank of deeply phenotyped HT patients that will serve as a powerful resource for current and future investigations. The aim of this study is to identify genetic variants underlying HT by performing the first GWAS focusing on HT exclusively. We will use newly recruited HT patients and 500 existing controls (from the “10,000 Dalmatians” study) in case-control GWAS and validate observed associations in an independent replication cohort. To further help in elucidating genetic contribution to HT we will perform pathway analysis and gene-interaction analysis using variety of environmental factors and medical records that will be collected from HT patients. We will also perform deep phenotype characterisation of HT patients that may provide additional clues about HT aetiology. This is timely planned study that aims to generate new knowledge that will advance our understanding of the genetic basis and underlying biological mechanisms of HT. This knowledge will be crucial in guiding the development of new prevention, diagnostic and therapeutic methods. Other benefits of this project include promotion of collaboration, transfer of knowledge, building of infrastructure and it will help in establishment of independent research carrier of principal investigator.]]></summary_en></project><project>
<id>1559</id><title_hr><![CDATA[Ultrazvučni sustav za određivanje parametara kompleksnih materijala u nelinearnim uvjetima rada]]></title_hr><title_en><![CDATA[Ultrasound system for  complex material parameters determination in the nonlinear working conditions]]></title_en><user_id>146</user_id><user_firstLast_name>Antonio Petošić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2013-11</proposal_call><code>UIP-2013-11-4996</code><acronim><![CDATA[ULTRASNON]]></acronim><duration>01.09.2014 - 31.12.2017</duration><status>Završio</status><financ_value>130.094,90 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Elektrotehnika, </scie_field_hr><scie_field_en>Electrical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id>962, 1392, 1379, 3153, 284, 682, </team_members_id><team_members_names><![CDATA[Ivan Đurek, Nazenin Bassiri Gharb, Marko Budimir, Dražan Skelin, Dragan Damjanovic, Marijan Klarica, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[material parameters, ultrasound, modular measurement system, nonlinear effects, effciency factor]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[The main objective of this project is to develop a new measurement procedure and to construct a modular measurement system for determination of complex material parameters that are used in ultrasound (US) systems  which are working in the nonlinear conditions. The materials&#39; parameters in existing US systems used in biomedicine and industry are determined at low excitation levels assuming linear physical principles and consistent thermodynamical conditions. This is different from real operating conditions where range of applied powers and types of excitation signals is various and very often far away from linear. The neglect of these nonlinearities in active and passive materials, used in the complete US system construction process, leads to the problem of the US systems’ efficiency factor in the nonlinear driving conditions. The construction of modular measurement system with included and modified interferometry and time of flight principle with added new measurement procedure is crucial for developing novel US systems with higher electroacoustic efficiency factors. The new method is based on tracking the resonant frequency changes of the nonlinear electro-mechanical-acoustical system for determination complex material parameters. The new modular measurement system will enable exposure of materials to the US fields with various driving conditions. Tracking the resonant frequency changes of excitated loading medium sample (active piezoceramic or passive construction elements or different types of loading mediums) is novel method for determination of material parameters when nonlinear effects appear in the loading mediums. As a result of more precise constructive material parameters determination, three prototypes of US systems with probes and electronic excitation circuits for applications in biomedicine and industry, with obtained higher electroacoustic efficiency factors will be developed, constructed and tested during this project.]]></summary_en></project><project>
<id>1560</id><title_hr><![CDATA[Održivost ekonomske politike i razvoja u Hrvatskoj]]></title_hr><title_en><![CDATA[Sustainability of Croatian Economic Policy and Development]]></title_en><user_id>503</user_id><user_firstLast_name>Jurica Šimurina</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2013-11</proposal_call><code>IP-2013-11-7031</code><acronim><![CDATA[SCrEPoDe]]></acronim><duration>01.10.2014 - 30.09.2018</duration><status>Završio</status><financ_value>50.913,27 eur</financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Ekonomija, </scie_field_hr><scie_field_en>Economy, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Ekonomski fakultet u Zagrebu]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Economics and Business]]></institution_en><team_members_id>3966, 3909, 3635, 3957, 4150, 3729, 3747, 4093, 3801, 4626, 3914, 3874, </team_members_id><team_members_names><![CDATA[Alka Obadić, Irena Raguž Krištić, Tomislav Globan, Tomislav Sekur, Josip Tica, Ozana Nadoveza, Vladimir Arčabić, Šime Smolić, Tamara Boras, Tomislav Gelo, Marija Penava, Ana Andabaka Badurina, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[sustainability, economic structure, resources, public sector economics, spatial economics]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[RESEARCH QUESTION: Do Croatian economic policies lead to sustainability with respect to scarce resources, demographic changes, spatial effects and economic structure?Long term Croatian economic policy and development stem from both short term policies and long term sustainability. By combining macroeconomic and development policies, the long term objectives of sustainability of natural resources, public sector economics, demographic changes, spatial economics and overall economic structure may be achieved. Thus, the goals of this research stem from the above stand point, and include:•	Establish development policies for Croatia based on sustainable use of natural resources•	Show how change of age structure in Croatia affects fiscal sustainability and short and long run economic development•	Explore how three way interaction among increasing returns, transportation costs, and movement of factors of production affect international, regional and urban development•	Analyze structure of Croatian economy suitable for sustainable and deeper integration into the EU•	Define integrative policies which lead to sustainable development of Croatian economyFor achieving above mentioned goals, the project team is separated into four equally contributing groups and is structured as follows:1. Sustainability of economic development within the context of scarce natural resources.2. Sustainability of public sector economics and the labor market in the context of demographic changes in Croatia.3. Sustainability of the degree of centralization in the context of spatial (international, urban and regional) economics.4. Sustainability of current economic structure within the context of the EU integrationOutcomes of the research will be innovative approach to controversy of long vs. short term development and stability, as well as integrative approach to different, and thus far, insufficiently interconnected fields of economic research.]]></summary_en></project><project>
<id>1563</id><title_hr><![CDATA[Primjena frazeološke teorije u frazeografiji ]]></title_hr><title_en><![CDATA[Application of phraseological theory in phraseography ]]></title_en><user_id>3653</user_id><user_firstLast_name>Željka Fink-Arsovski</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2013-11</proposal_call><code>IP-2013-11-4054</code><acronim><![CDATA[FRAZLOGGRAF]]></acronim><duration>01.07.2014 - 30.06.2018</duration><status>Završio</status><financ_value>18.461,74 eur</financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Filologija, </scie_field_hr><scie_field_en>Philology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Filozofski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Humanities and Social Sciences]]></institution_en><team_members_id>3577, 1477, 1516, </team_members_id><team_members_names><![CDATA[Branka Barčot, Anita Hrnjak, Antica Menac, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[phraseme, phraseology, phraseography, dictionaries, contrastive linguistics, Croatian, Slavic languages, non-Slavic languages]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[The active development of phraseology as an independent linguistic discipline began in the former USSR in the 1950s. Phraseology is primarily a linguistic and culturally multi-layered discipline. The basic unit of phraseology is a phraseme (idiom). It consists of at least two components. Its characteristic is that it is not created in the process of speaking, but is included in discourse as an already known whole. Its main features are continuity of use, integrity and a solid structure, higher or lower degree of desemanticization, a colourful nature, expressiveness and connotative meaning. The project will primarily include theoretical work on analyzing Croatian phrasemes from various aspects. Furthermore, with the application of the method of contrastive analysis, structural, semantic, etymological, motivational and cultural similarities and differences between Croatian idioms and idioms of other Slavic and non-Slavic languages will be examined. We consider the latter to be extremely important because in this way Croatian idioms would be placed in the context of European idioms. The second part of the project proposal relates to phraseographical work. Phraseography is an area that deals with the issue of compiling phraseological dictionaries. The publication of several phraseological dictionaries is planned. Particularly important will be the two phraseological dictionaries which will be completely new in a conceptual sense (a trilingual dictionary of associations and a dictionary of gender-marked phrasemes). All dictionaries will be compiled according to the latest phraseographical methodology. In addition, we should mention the work on the updated edition of the Bibliography of Croatian phraseology. We believe both of these aspects to be very important for the recognition of Croatian phraseology and phraseography within European phraseology, phraseography, Slavic studies and philology.]]></summary_en></project><project>
<id>1578</id><title_hr><![CDATA[Multidisciplinarni klaster za istraživanje tranzicijskog kriminaliteta - trgovanje ljudima, korupcija i gospodarski kriminalitet]]></title_hr><title_en><![CDATA[Multidisciplinary Research Cluster on Crime in Transition - Trafficking in Human Beings, Corruption and Economic Crime]]></title_en><user_id>125</user_id><user_firstLast_name>Davor Derenčinović</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2013-11</proposal_call><code>IP-2013-11-1949</code><acronim><![CDATA[Trans.Crim.]]></acronim><duration>01.01.2015 - 31.12.2018</duration><status>Završio</status><financ_value>59.893,95 eur</financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Pravo, </scie_field_hr><scie_field_en>Law, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Pravni fakultet u Zagrebu]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Law]]></institution_en><team_members_id>3828, 4083, 4111, 4199, 4292, 4357, 4492, 4457, 229, 3052, 4535, 580, 4165, 4158, 4222, 2814, 2928, 4522, 4297, 4187, 4274, 4763, 4774, 4955, 4467, 5073, 5549, </team_members_id><team_members_names><![CDATA[Maja  Munivrana Vajda, Anna-Maria Getoš, Aleksandar Maršavelski, Marta Dragičević Prtenjača, Vanja-Ivan Savić, Davorin  Lapaš, Peter Henning, Vanda Božić, Jasenko Marin, Iva  Savić, Dražen Dragičević, Hrvoje Lisičar, Nina Gumzej, Tihomir Katulić, Marko Jurić, Nikoleta Radionov, Mišo Mudrić, Richard Farkas, Marko Šikić, Lana Ofak, Frane  Staničić, Marko Turudić, Mateja Crnković, Ivana  Jaramaz Reskušić, Sanja Milivojevic, Suncana Roksandic Vidlicka, Leo Cvitanović, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[crime, transition,research cluster, trafficking in human beings, corruption, economic crime]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[The first project research focus is human trafficking, modern age slavery that has been condemned by the ECHR as a gross human rights violation. The number of those identified as victims in Croatia remains low. However, there is no dispute that the dark number in this field is significant. This could be explained by the structural deficiencies of national anti-trafficking policies and disregard of research and multidisciplinary approach in addressing three key priority areas – that of prevention, protection of victims, and prosecution of perpetrators. The need for the research based policies is indispensible for Croatia as a new EU member state that has been under the risk of turning into a country of destination for victims from the Western Balkan countries as well as from the countries either affected from internal instabilities and conflicts (e.g. Syria) or from the African countries (e.g. Nigeria). Therefore, the aim of this project is to contribute, through establishment of fully operational informal network of experts from different disciplines, in promoting research based policies and to provide support for establishment of National Rapporteur on THB (this is an obligation under the Directive 2011/36/EU that still has not been fully implemented by Croatia). The second research focus is corruption and economic crime, major obstacles for further development of society stretched between systemic dysfunctions characteristic for transition period and the rule of law standards formally accepted through the process of European integration. Informal network of experts will address the issues of liability of legal persons for corruption and economic criminal offences, shortcomings in legislation and case law, legislation that regulate access to information etc.]]></summary_en></project><project>
<id>1579</id><title_hr><![CDATA[Diofantove m-torke, eliptičke krivulje, Thueove i indeksne jednadžbe]]></title_hr><title_en><![CDATA[Diophantine m-tuples, elliptic curves, Thue and index form equations]]></title_en><user_id>95</user_id><user_firstLast_name>Andrej Dujella</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2013-11</proposal_call><code>IP-2013-11-6422</code><acronim><![CDATA[DIOPHANTINE]]></acronim><duration>01.07.2014 - 30.06.2018</duration><status>Završio</status><financ_value>101.962,27 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Matematika, </scie_field_hr><scie_field_en>Mathematics, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>1267, 1262, 1282, 2600, 3264, 1264, 2990, 1348, 1251, 1312, 4086, 17746, 23281, </team_members_id><team_members_names><![CDATA[Ivica Gusić, Alan Filipin, Borka Jadrijević, Zrinka Franušić, Mirela Jukić Bokun, Ana Jurasić, Tomislav Pejković, Ivan Soldo, Petra Tadic, Sanda Bujačić, Nikola Adžaga, Marija Bliznac, Vinko Petričević, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[Diophantine equations, elliptic curves, Diophantine approximations, polynomials, cryptography]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[The proposed project will coordinate and support research activities of Croatian number theory group. One of the main topics of research in this project will be Diophantine m-tuples (sets with the property that the product of its any two distinct elements increased by 1 is a perfect square) and their generalizations. The first Diophantine quadruple {1,3,8,120} was found by Fermat. Baker and Davenport proved that Fermat&#39;s set cannot be extended to a quintuple. This result motivated the famous conjecture that there does not exist a Diophantine quintuple. Dujella proved that there does not exist a Diophantine sextuple and that there are only finitely many Diophantine quintuples. Recently, Filipin, Fujita and Elsholtz significantly improved previously known upper bounds for the number of Diophantine quintuples, but the main conjecture still remains open. Various generalizations of Diophantine m-tuples will be studied, in particular, considering the problem in the rings of integers of number fields of small degree.  Diophantine triples were used by Dujella in construction of high-rank elliptic curves over Q and Q(T) and new results in that direction are expected. In determining exactly the Mordell-Weil group of several elliptic curves over Q(T), an important tool is recent algorithm by Gusić and Tadić for finding rationals at which the specialization map is injective. We plan to improve and extend this algorithm for elliptic curves over K(T) for general number fields K. Members of the group will also work on Thue, Thue-Mahler and index forms equations, problems related to sums of divisors, polynomial root separation and applications of Diophantine approximations to cryptanalysis. The results of the research will be published in respectable journals and presented on international conferences. Through this project we will intensify our scientific connections with international number-theorists and qualify young researchers for scientific research in number theory.]]></summary_en></project><project>
<id>1585</id><title_hr><![CDATA[Primjena metode scenarija u planiranju i razvoju ruralnih područja Hrvatske]]></title_hr><title_en><![CDATA[Croatian Rural Areas: Scenario-based Approach to Discuss Planning and Development]]></title_en><user_id>3724</user_id><user_firstLast_name>Aleksandar Lukić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2013-11</proposal_call><code>UIP-2013-11-4513</code><acronim><![CDATA[Croruris]]></acronim><duration>01.10.2014 - 30.09.2017</duration><status>Završio</status><financ_value>67.370,48 eur</financ_value><scie_area_hr>Društvene znanosti, Biotehničke znanosti, Prirodne znanosti, </scie_area_hr><scie_area_en>Social sciences, Biotechnical sciences, Natural sciences, </scie_area_en><scie_field_hr>Ekonomija, </scie_field_hr><scie_field_en>Economy, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>6156, 6662, 4934, 4600, 4881, 6407, 5671, 5139, 4846, 6137, </team_members_id><team_members_names><![CDATA[Dane Pejnović, Maja Štambuk, Anica Čuka, Ornella Mikuš, Ivan Zupanc, Ivana Lučev, Ivan Čanjevac, Petra Radeljak, Luka Valožić, Marin Cvitanović, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[scenario, rural areas, typology, planning, modelling, Delphi, Croatia]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[The main anticipated result of the interdisciplinary CRORURIS study is the production of a set of alternative future scenarios for Croatian rural areas in 2030 with the goal of encouraging informed and evidence-based public debate on rural futures. Rural areas account for almost 90% of the land and are home to almost half of the population, both in Croatia and the EU. They are still the most important food production zones in Europe, although this primary function has been challenged by numerous modernization and globalization processes and complemented by other economic, social, cultural, and environmental functions. As a result, we have witnessed the (re)emergence of heterogeneous and diversified rural areas, juxtaposing depopulation and land abandonment in some regions, and tourist development or agricultural intensification in others. Given their size, population number, functions and variety of challenges they face, the question of future of rural areas is one of the most pressing issues in Europe today. This is evident from recent scenario-based approaches to study future trends and driving forces for rural Europe, both in academic and political discourse, on national and EU level (e.g. SCENAR 2020, EURURALIS etc.). On the other hand, although the majority of rural areas in Croatia face tremendous demographic and economic challenges, to our knowledge no scenario-based research has been done and only a few partial impact analyses have been conducted in recent Croatian agricultural policy. Therefore, the main objectives of the CRORURIS study are as follows: 1. to develop a conceptual framework for understanding recent change in rural Croatia; 2. to develop methodological framework for identifying predominant trends and key uncertainties, differentiating them geographically and projecting them forward using statistical modelling and Delphi method; 3. to construct alternative future scenarios and relate them to the context of rural Europe.]]></summary_en></project><project>
<id>1588</id><title_hr><![CDATA[Istraživaje prirodnih spojeva i aroma: kemijsko profiliranje i otkrivanje potecijala]]></title_hr><title_en><![CDATA[Research of natural products and flavours: chemical fingerprinting and unlocking the potential]]></title_en><user_id>367</user_id><user_firstLast_name>Igor Jerković</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2013-11</proposal_call><code>IP-2013-11-8547</code><acronim><![CDATA[NaPro-Flav]]></acronim><duration>01.06.2014 - 31.05.2018</duration><status>Završio</status><financ_value>87.563,15 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, </scie_field_hr><scie_field_en>Chemistry, </scie_field_en><institution_hr><![CDATA[Sveučilište u Splitu, Kemijsko-tehnološki fakultet]]></institution_hr><institution_en><![CDATA[University of Split, Faculty of Chemistry and Technology]]></institution_en><team_members_id>664, 666, 3752, 1139, 1133, 507, 1520, 4186, 4185, 771, </team_members_id><team_members_names><![CDATA[Ani Radonić, Marina Zekić, Marina Kranjac, Maja Kliškić, Senka Gudić, Carlo Ignazio Giovanni Tuberoso, Zvonimir Marijanović, Dragan Bubalo, Lidija Svečnjak, Goran Baranović, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[natural products, flavours, preparative techniques, chromatography, spectroscopy, antioxidant assays, corrosion inhibition assays]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[The proposed project develops up-to date topic in the subject area, offers high-quality research of natural products (NPs) and flavours (FLs) and tends to impact the biodiversity, traceability and authentication issues of targeted samples (major EU concerns), as well as to unlock the potential (useful activities of the samples/NPs). Targeted samples are unexplored or insufficiently investigated honeys, honeydews, bee-products, wines, cheese, others. While characteristic NPs (secondary metabolites) already possess flavours, other flavour compounds can derive from precursors during processing, fermentation, dry-curing, heating, others (e.g. Maillard reactions, Strecker degradations, retro-aldol reactions, Amadori rearrangements, heterocyclizations, lipid oxidations and others). NPs/FLs isolation involves application of selective preparative procedures followed by the organic analysis applying modern chromatographic and spectroscopic techniques. Specific project goal is to determine reliable chemical fingerprints of targeted samples depending on biodiversity of natural sources in different regions. Varieties of acetate, shikimate, mevalonate and/or deoxyxylulose biosynthetic pathway derivatives are expected to be found. Among them, it can be possible to find specific or nonspecific chemical biomarkers characterizing certain sources. In addition, the obtained NPs or selected samples will be evaluated in order to unlock their potential, particularly antioxidant activity by different assays and corrosion inhibition potential with in-situ and ex-situ electrochemical/non-electrochemical techniques. Project work plan includes: 1) the samples selection and preliminary characterisation; 2) set-up of preparative/chromatographic/spectroscopic methods followed by elaboration of the obtained chemical fingerprints); 3) set-up of antioxidant/corrosion inhibition assays followed by unlocking the samples/NPs potential; 4) training of young researchers/cooperation.]]></summary_en></project><project>
<id>1590</id><title_hr><![CDATA[Taksonomija, Ekologija i Uporaba rogača (Ceratonia siliqua L.) i lovora (Laurus nobilis L.) u Hrvatskoj]]></title_hr><title_en><![CDATA[Taxonomy, Ecology and Utilization of Carob Tree (Ceratonia siliqua L.) and Bay Laurel (Laurus nobilis L.) in Croatia]]></title_en><user_id>372</user_id><user_firstLast_name>Siniša Srečec</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2013-11</proposal_call><code>IP-2013-11-3304</code><acronim><![CDATA[TEUCLIC]]></acronim><duration>07.07.2014 - 06.10.2018</duration><status>Završio</status><financ_value>95.553,20 eur</financ_value><scie_area_hr>Biotehničke znanosti, Prirodne znanosti, Biomedicina i zdravstvo, </scie_area_hr><scie_area_en>Biotechnical sciences, Natural sciences, Biomedicine and health sciences, </scie_area_en><scie_field_hr>Biotehnologija, </scie_field_hr><scie_field_en>Biotechnology, </scie_field_en><institution_hr><![CDATA[Veleučilište u Križevcima]]></institution_hr><institution_en><![CDATA[Križevci University of Applied Sciences]]></institution_en><team_members_id>4381, 4864, 5669, 5474, 6201, 313, 6170, 6304, 6326, 5692, 4916, 5084, 6046, 5510, 5662, 5690, 5630, 6097, 6236, 5853, 5364, 6184, 1317, </team_members_id><team_members_names><![CDATA[Dario Kremer, Snježana Bolarić, Nada  Bezić, Dubravka Dujmović Purgar, Irena Vedrina-Dragojević, Maja Popović, Ingrid Bauman, Marija Vukobratović, ŽELIMIR VUKOBRATOVIĆ, Ivka Kvaternjak, Ksenija Karlović, Renata Jurišić Grubešić, Nives Marušić, Gordan Mršić, Daniel Špoljarić, Zvjezdana Augustinović, Dejan Marenčić, Ivna Dragojević Müller, Maja Benković, Tomislava Peremin Volf, Renata Erhatić, Marinko Petrović, Valerija Dunkić, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[carob tree, Ceratonia siliqua L., bay laurel, Laurus nobilis L., biodiversity, utilization]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Carob tree (Ceratonia siliqua L.) is nutritionally and protectively very valuable plant, especially seeds which are widely used in the food industry. Carob pods and juice has a very important role in diet of Mediterranean countries. Bay laurel (Laurus nobilis L.) is also nutritionally and protectively very valuable plant overspread on the Mediterranean basin. The most important parts of the bay laurel plant are leaves which are used in traditional medicine, and in the food, pharmaceutical and cosmetic industries. Both species are also an important component of the Mediterranean vegetation and grows in marginal and prevailing calcareous soils. Since there is limited knowledge about Croatian populations of carob tree and bay laurel this studies will be conducted to determine morphological, genetic, phytochemical and ecological traits of Croatian populations of these species. Morphometric investigations will be made on leaves and fruits (carob tree) samples gathered in situ, while the genetic variability will be determined using AFLP analysis of genomic DNA isolated from the leaves. The content of polyphenolic compounds, antioxidant activity in vitro with the use of UV-Vis spectrophotometer, and the share of macro and microelements using emission spectrometry (AES) will be determined in the leaves and fruits samples. Carob based soft drinks and pastry fillings will be developed as new products on Croatian market. Additionally, possible positive effects of addition supplement of carob tree in standard food for animals on health and production parameters in weaned pigs as the natural replacement of antibiotic growth promoters will be investigated.]]></summary_en></project><project>
<id>1596</id><title_hr><![CDATA[Pouzdanost konstrukcije oštećenog naftnog tankera u Jadranskom moru]]></title_hr><title_en><![CDATA[Structural reliability of damaged oil tanker in the Adriatic Sea]]></title_en><user_id>810</user_id><user_firstLast_name>Joško Parunov</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2013-11</proposal_call><code>IP-2013-11-8658</code><acronim><![CDATA[DATAS]]></acronim><duration>01.09.2014 - 31.08.2018</duration><status>Završio</status><financ_value>126.973,39 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Brodogradnja, </scie_field_hr><scie_field_en>Naval architecture, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet strojarstva i brodogradnje]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Mechanical Engineering and Naval Architecture]]></institution_en><team_members_id>6629, 6823, 6385, 6793, 6254, 6626, 6227, 5584, 6309, 6166, 6437, 6414, 6209, 6640, 5212, 6271, 6483, 17869, 17868, 17787, </team_members_id><team_members_names><![CDATA[Vedran Žanić, Većeslav Čorić, Andreja Werner, Nastia Degiuli, Smiljko Rudan, Vedran Slapničar, Jerolim Andrić, Ivan Ćatipović, Stanislav Kitarović, Pero Prebeg, marko tomić, Karlo Pirić, Maro Ćorak, Jadranka Radanović, Branka Bužančić Primorac, Luka Mudronja, Ivan Munić, Marko Katalinic, Ivana Martić, Ivana Gledić, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[oil tanker, Adriatic sea, damaged ship, structural reliability, risk assessment]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[The aim of the project is to propose methodology of structural safety assessment of the damaged oil tanker in the Adriatic Sea and to set-up procedure for rational decision making of ship in the situations requiring emergency response actions. This can also be used to develop more rational rules and regulations related to the traffic of large ships operating in the Adriatic and to investigate possibilities of a ship structural design improvement with respect to the most dangerous incident types. Despite advancements in navigation systems, ship accidents continue to occur, the most recent one being the grounding of a cruise ship Costa Concordia. These accidents have resulted in the loss of cargo, pollution of environment, and most unfavorable the loss of life. Accidental damages of ships can occur in any number of ways. The two cases which exhibit most concerns are the collision between ships and hard grounding on seabed. When a ship is damaged, the operators need to decide on immediate repair actions by evaluating the effects of the damage on safety of the ship by considering simultaneously effects of the damage in the hull girder ultimate bending moment and in the applied loads (wave and still-water induced bending moments). In general, as the consequence of an accident still water loads on ship will considerably increase, while the ship strength will decrease. Disaster of the tanker Prestige in 2002 clearly showed that the ship in damaged condition can be broken due to the above mentioned phenomenon and sink as the most unfavorable outcome of such an accident with likely spillage of a large amount of pollutant oil on board.Since the Adriatic is an enclosed sea basin, with the low level of the activity of the sea waves and current, an accident of the oil tanker with significant oil spill would make irreversible ecological disaster with enormous economic losses. Therefore, safety of oil transportation in the Adriatic is a major concern of the whole society.]]></summary_en></project><project>
<id>1598</id><title_hr><![CDATA[Elektrokemijski superkondenzator visoke snage i velikog sadržaja energije za primjenu u električnim vozilima]]></title_hr><title_en><![CDATA[High power-high energy electrochemical supercapacitor for hybrid electric vehicles]]></title_en><user_id>961</user_id><user_firstLast_name>Zoran Mandić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2013-11</proposal_call><code>IP-2013-11-8825</code><acronim><![CDATA[ESUP-CAP]]></acronim><duration>03.11.2014 - 02.11.2018</duration><status>Završio</status><financ_value>126.856,46 eur</financ_value><scie_area_hr>Tehničke znanosti, Prirodne znanosti, </scie_area_hr><scie_area_en>Technological sciences, Natural sciences, </scie_area_en><scie_field_hr>Kemijsko inženjerstvo, </scie_field_hr><scie_field_en>Chemical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet kemijskog inženjerstva i tehnologije]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Chemical Engineering and Technology]]></institution_en><team_members_id>3029, 3035, 3651, 4131, 5278, 6109, 17810, 19020, 21370, </team_members_id><team_members_names><![CDATA[Višnja Horvat-Radošević, Katja Magdić, Marijana Kraljić Roković, Suzana Sopčić, Gabrijela Slavić, Željko Ban, Denis Sačer, Davor Antonić, Antonio Ivanković , ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[Supercapacitors, electrochemical energy sources, electric vehicles, renewable energy, carbon electrodes, conducting polymers]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[In the context of renewable and “clean” energy sources, the main aim of the present project is to provide a technology output for the novel, high power-high energy electrochemical supercapacitor device that could be implemented in hybrid electric vehicles. The project addresses an interdisciplinary research and combines fundamental and applied research activities in chemical, electrical and environmental engineering fields. The highest possible scientific and technological impact of the project is supposed to be ensured by joining of the human and experimental resources of several different Croatian’s groups. The novel, high power-high energy electrochemical supercapacitor device will be based on hybridization of two different types of electrodes (double-layer and pseudo-capacitive) in a respective electrolyte. Various forms of carbon and carbon based binary and ternary composites with transition metal oxides and/or conducting polymers will be tested as negative and positive electrodes, respectively. For being competitive in the area of energy storage, the tested electrodes should fulfil the requirements of high specific capacitance, long cycle-life, good charge/discharge efficiency, low self discharge and adequate operating voltage. The project is planned to be realized mostly on the basis of fundamental experimental research directed towards increasing of the basic knowledge comprising choice of material, proper design of electrodes and careful elucidation of all underlying physical and chemical processes at active electrode/electrolyte interfaces. The results of fundamental experimental research will be utilized for selection of proper electrodes, their arrangement into electrochemical supercapacitor device, optimization of device to the energy content and power ability, testing of device in practical environment and implementation of device into hybrid electrical vehicle. ]]></summary_en></project><project>
<id>1603</id><title_hr><![CDATA[Karakterizacija niskotemperaturne molekulske dinamike sustava s neuređenom rešetkom metodom ESR]]></title_hr><title_en><![CDATA[Low-temperature molecular dynamics of systems exhibiting lattice disorder probed by ESR]]></title_en><user_id>510</user_id><user_firstLast_name>Marina Ilakovac Kveder</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2013-11</proposal_call><code>IP-2013-11-1108</code><acronim><![CDATA[DESiRe]]></acronim><duration>01.09.2014 - 31.08.2018</duration><status>Završio</status><financ_value>105.096,96 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, </scie_field_hr><scie_field_en>Physics, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>3280, 3546, 3545, 1213, 4209, 2647, 17790, </team_members_id><team_members_names><![CDATA[Boris Rakvin, Mladen Andreis, Srećko Valić, Dalibor Merunka, Nadica Maltar Strmečki, Dijana Žilić, Jurica Jurec, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[ESR, disorder, boson peak, spin relaxation, spin frustration]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Systems exhibiting geometrical frustration challenge contemporary condensed-matter physics due to the fact that they exhibit strange dynamical properties such as boson peak excitations, which strongly deviate from the standard Debye model. Therefore, the quest for a self-consistent theory applicable for description of systems with lattice disorder is a fundamental issue. Despite the efforts put into investigation of vibrational excitations in disordered systems at low temperatures, the consensus about their physical origin is still lacking. This project aims to address the subject by fully exploiting the advantage of embedded paramagnetic centres through focusing on their relaxation behaviour, which bears the information about the local frustration of the environment. The energy exchange within the spin system and between the spin system and the lattice will be detected by electron spin resonance spectroscopy (ESR) as a function of disorder in the vicinity of the paramagnetic centre. This we can control by preparing the host matrix in the glassy, supercooled or crystalline state. We propose to investigate the specific molecular dynamics due to the presence of disorder in the system while switching the very same compound doped with paramagnetic centres from disordered to more ordered state, such as from glassy to crystalline state. Additionally, the microscopic picture of local disordered sites will be examined in other systems doped with paramagnetic centres such as various polymer matrices or hydrogen-bonded crystals. The origin of local disorder will be correlated with the influence of different numbers of hydrogen bonds in the vicinity of paramagnetic site as well as with the degree of local spin frustration. We expect that this comparative study will enlighten the peculiarities of vibrational density of states of amorphous materials and contribute towards development of the unique model of low-temperature molecular dynamics of disordered systems in general.]]></summary_en></project><project>
<id>1617</id><title_hr><![CDATA[Modeliranje ekonomskog rasta - napredno sekvenciranje i algoritam predviđanja]]></title_hr><title_en><![CDATA[Modelling Economic Growth - Advanced Sequencing and Forecasting Algorithm]]></title_en><user_id>3894</user_id><user_firstLast_name>Marinko Škare</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2013-11</proposal_call><code>IP-2013-11-9481</code><acronim><![CDATA[MEGASFORA]]></acronim><duration>16.06.2014 - 15.06.2018</duration><status>Završio</status><financ_value>73.571,48 eur</financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Ekonomija, </scie_field_hr><scie_field_en>Economy, </scie_field_en><institution_hr><![CDATA[Sveučilište Jurja Dobrile u Puli]]></institution_hr><institution_en><![CDATA[Juraj Dobrila University of Pula]]></institution_en><team_members_id>1166, 2963, 1268, 1331, 4628, 1094, 1055, 6579, 6549, 5351, 5675, 5391, 5396, 5635, 5036, 4659, 4863, 5062, 6832, 19122, </team_members_id><team_members_names><![CDATA[Steve Keen, Guglielmo Maria Caporale, Roman Semko, Daniel Tomić, Saša Stjepanović, Hazbo Skoko, Sanja Blažević, Tea Hasić, Sabina Lacmanović, Katarina Kostelić, Nawazish Mirza, Danijela Rabar, Soumitra Sharma, TOMASZ WOLOWIEC, Manuel Benazić, ROMINA  PRŽIKLAS DRUŽETA, Tea  Golja, Dean Sinković, Valter Boljunčić, Mieta Bobanović, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[Growth, forecasting, algorithm, dynamic models, golden triangle model]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[The main objective of the project is to give a final and scientifically based answer to the question whether economic growth can be forecasted and business cycles predicted? A practical objective of the proposed research project is to build an optimal economic growth/cycle model for Croatia using Advanced Growth Sequencing and Forecasting Algorithm (AGSIFAL) that we plan to build. In order to do so, an algorithm (selected from the best of artificial neural network model, structural econometric model, dynamic general equilibrium model, nonlinear econometric model, golden triangle model) for cycle/growth sequencing and forecasting will be developed. Sequencing of the economic growth on a international scale (119 countries) will be performed using business cycle tracer methods and novel golden triangle model developed by Škare (2010). For this purpose, advanced cycle/growth algorithm will be created. Using individual country data as primer, we plan to isolate growth determinants using three dimensional golden triangle model and spectral analysis techniques.  Output, inflation and employment form the three dimension of the cycle/growth triangle that will be used for sequencing growth. After a growth sequencing is finished, a best forecasting algorithm is built from the derived growth sequencing bases. Pairing isolated growth determinants help us to rebuild a growth sequence. Using different algorithm models, reconstructed economic growth series is compared to the actual growth series (observed data). Algorithm resulting in the smallest forecast error (RMSE) is selected as optimal to explain economic growth and predict business cycles. EThis conclusion will have important theoretical and policy implications both for the science of economics and economic agents on the market. ]]></summary_en></project><project>
<id>1619</id><title_hr><![CDATA[Razvoj i upotreba modela za procjenu potencijala za rast za mala i srednja poduzeća u Hrvatskoj]]></title_hr><title_en><![CDATA[Development and application of growth potential prediction models for small and medium enterprises in Croatia]]></title_en><user_id>2825</user_id><user_firstLast_name>Nataša Šarlija</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2013-11</proposal_call><code>IP-2013-11-3933</code><acronim><![CDATA[CROSMEGROWTH]]></acronim><duration>01.07.2014 - 30.06.2018</duration><status>Završio</status><financ_value>60.817,57 eur</financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Ekonomija, </scie_field_hr><scie_field_en>Economy, </scie_field_en><institution_hr><![CDATA[Sveučilište Josipa Jurja Strossmayera u Osijeku, Ekonomski fakultet u Osijeku]]></institution_hr><institution_en><![CDATA[Josip Juraj Strossmayer University of Osijek, Faculty of Economics]]></institution_en><team_members_id>4247, 6530, 5265, 305, 5065, 4797, 17875, </team_members_id><team_members_names><![CDATA[Sanja Pfeifer, Slavica (Vjekoslava) Singer, Marina Jeger, Danijel Grahovac, Anamarija Delić, Sunčica  Oberman Peterka, Ana Bilandžić, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[prediction of growth potential, high-growth SMEs, creative industry, policy recommendation for high growth SMEs, access to finance for high-growth SME]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[The importance of high-growth enterprises for job creation has been widely substantiated by economic research in recent years. The number and share of high-growth enterprises is relatively small, but the number and share of jobs they create is disproportionally large. The small and medium enterprises with the potential of growth are in the focus of this project. Two overarching goals of this project are:1.	Development of growth potential prediction models for SMEs in CroatiaThe main activities leading up to this goal are: (i) to analyse previous studies relevant for the topic of SMEs&#39; growth potential; (ii) to develop growth potential prediction models for SMEs in Croatia; (iii) to make the models for assessing growth potential available to SMEs to use for purposes of assessing and improving their businesses; (iv) to compare differences in growth potential among SMEs from main industries; (v) to analyse growth potential of SMEs within creative industries and within manufacturing industries.  2.	Providing recommendations to policy makers, recommendation for development of educational programs for SME owners and managers, and recommendations related to sources of finance available to SMEsBased on the research results and models created as part of this project, the main recommendations related to growth potential of SMEs will cover areas of: (i) policy making; (ii) education; and (iii) sources of finance. In recent years policy makers have shown increased interest in fostering fast growing enterprises as they are seen as a key driver of economic growth and employment. Studies conducted in listed companies have showed that two key aspects in supporting high-growth companies are education and access to finance. To allow for comparison of other countries with Croatia, results of this project will be published in relevant scientific journals. To help boost Croatian economy, the results will be presented to all stakeholders interested in this topic.]]></summary_en></project><project>
<id>1630</id><title_hr><![CDATA[Molekularna epidemiologija nekih invazijskih oboljenja divljih životinja]]></title_hr><title_en><![CDATA[Molecular epidemiology of selected parasitic diseases of wildlife]]></title_en><user_id>3919</user_id><user_firstLast_name>Dean Konjević</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2013-11</proposal_call><code>UIP-2013-11-3421</code><acronim><![CDATA[EpiMol]]></acronim><duration>01.09.2014 - 31.08.2017</duration><status>Završio</status><financ_value>128.342,96 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo, Prirodne znanosti, Biotehničke znanosti, </scie_area_hr><scie_area_en>Biomedicine and health sciences, Natural sciences, Biotechnical sciences, </scie_area_en><scie_field_hr>Veterinarska medicina, </scie_field_hr><scie_field_en>Veterinary medicine, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Veterinarski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Veterinary Medicine]]></institution_en><team_members_id>6172, 6141, 5928, 6315, 5763, 6460, 6444, 6598, 4742, 17766, </team_members_id><team_members_names><![CDATA[Ana Galov, Haidi Arbanasić, Krešimir Krapinec, Julian Drewe, Marina Pavlak, Magda Sindičić, Franjo Martinković, Živičnjak Tatjana, Krešimir Severin, Miljenko Bujanić, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[molecular epidemiology, wildlife, parasitology, MHC genes, GIS modelling]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Wildlife diseases are increasingly important field of veterinary medicine, conservation medicine, and protection of human health. Of all wildlife diseases parasitic diseases participate with 75%. In this project, selection of diseases encompasses potentially fatal diseases with high economic impact, frequently present disease with mainly subclinical course, and potential zoonotic diseases. Main objectives of the project are to: 1) determine the occurrence of selected parasitic diseases of gastrointestinal and respiratory system in red deer, roe deer, wild boar and jackal, 2) determine environmental factors that contribute disease occurrence, 3) determine the epidemiology of selected parasitic disease of wildlife, 4) analyse MHC genes expression in animals with different health status, and 5) analyse obtained results with molecular epidemiology tools. This will be achieved by interdisciplinary research team (composed of veterinarians, biologists and forester) divided in four main topics: parasitology, environmental conditions and GIS modelling, MHC genes polymorphism in wildlife and epidemiology and molecular epidemiology. Other objectives of the project are to facilitate establishment of internationally competent multidisciplinary research team through research, cooperation and continuing professional development and to enhance development of molecular epidemiology in Croatia. With such comprehensive approach proposed project offers for the first time in Croatia creation of multidisciplinary team that will analyse all aspects of wildlife diseases and important environmental factors. Furthermore, molecular epidemiology will provide insights into susceptibility to disease and potential survival rate that is dependent on major histocompatibility complex variations.]]></summary_en></project><project>
<id>1641</id><title_hr><![CDATA[Liječenje neuropatske boli stimulacijom spinalnog ganglija]]></title_hr><title_en><![CDATA[Treating neuropathic pain with dorsal root ganglion stimulation]]></title_en><user_id>4000</user_id><user_firstLast_name>Damir Sapunar</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2013-11</proposal_call><code>IP-2013-11-4126</code><acronim><![CDATA[NeuroMod]]></acronim><duration>15.12.2014 - 14.12.2019</duration><status>Završio</status><financ_value>132.722,81 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Splitu, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Split School of Medicine]]></institution_en><team_members_id>768, 4233, 4510, 4384, 4379, 4511, 4417, 4561, 3385, 6089, 6077, 17768, 21335, </team_members_id><team_members_names><![CDATA[Adriana Banozic, Antonia Jeličić Kadić, Livia Puljak, Marta Balog, Senka Blažetić, Vedrana Ivić, Robert Blažeković, Ozana Katarina Tot, Ivica Grković, Danijel Nejašmić, Damir Kovačić, Tihana Repić, Ivana Vuka, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[neuropathic pain, nerve injury, neuromodulation, dorsal root ganglion, ganglionic field stimulation, T-junction, microelectrode arrays]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Neuropathic pain is a debilitating disease of the somatosensory system that has a huge socio-economic impact. Numerous studies, including those from our laboratory have established that the injured dorsal root ganglion (DRG) is the important site for pathophysiologic changes that lead to development of neuropathic pain. Although DRG neurons are critical for the onset of neuropathic pain, there are no relevant clinical treatments for neuropathic pain that target this organ. With this proposal we aim to prove that neurostimulation techniques can be successfully used to manipulate neuronal function at the level of experimentally injured DRGs. In order to test this hypothesis we will construct a fully implantable neuronal stimulator for freely moving rats, devise an implantation technique and define stimulation protocols. This stimulator will be tested in rats with two types of experimentally induced nerve injury; spinal nerve ligation and carrageenan-induced inflammation model. Since this invasive procedure bears substantial risk of inflammation and other adverse neural tissue response, which can induce pain per se, we will also investigate connective tissue fibrosis and neuroinflammatory response in neural tissue of DRG and dorsal horn. The effect of the stimulation on excitability of injured DRG neurons will also be tested in vitro. Our last aim builds on our previous study in which we showed that neuronal injury may disable T-junction filtering and thereby increase the net conduction of afferent traffic. With this proposal we will test whether stimulation can modulate filtering properties of DRG T-junction. This will be addressed using recordings from injured sensory neurons of dorsal root ganglia excised from adult rats, and recently developed methodology that will allow us to electrically visualize action potential propagation in DRG neurons grown over custom microelectrode arrays.]]></summary_en></project><project>
<id>1643</id><title_hr><![CDATA[Uokvireno ziđe - kompozitni nosivi sustav kod armirano-betonskih zgrada]]></title_hr><title_en><![CDATA[Frame - masonry composites for modelling and standardization]]></title_en><user_id>3000</user_id><user_firstLast_name>IVICA GULJAŠ</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2013-11</proposal_call><code>IP-2013-11-3013</code><acronim><![CDATA[FRAmed-MAsonry]]></acronim><duration>01.09.2014 - 31.08.2017</duration><status>Završio</status><financ_value>96.068,75 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Građevinarstvo, </scie_field_hr><scie_field_en>Civil engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište Josipa Jurja Strossmayera u Osijeku, Građevinski i arhitektonski fakultet Osijek]]></institution_hr><institution_en><![CDATA[Josip Juraj Strossmayer University of Osijek, Faculty of Civil Engineering and Architecture Osijek]]></institution_en><team_members_id>3693, 2730, 3637, 3000, 4956, 3178, 3560, 3043, 3049, 3699, 2971, 1408, 7253, 3063, 765, 6190, 6177, 4046, 7284, 4805, 5368, 7288, 7309, 7489, 7389, </team_members_id><team_members_names><![CDATA[Damir Markulak, Damir Varevac, Petar Brana, IVICA GULJAŠ, MIRJANA BOŠNJAK-KLEČINA, JURKO ZOVKIĆ, Đurđica Matošević, Tanja Kalman Šipoš, Marin Grubišić, Goran Gazić, Mario Galić, Ivan Kraus, Damir Džakić, Davorin Penava, Mehmed Čaušević, Tatjana Isaković, Matej Fischinger, Veronika  Shendova, Golubka Nechevska-Cvetanovska, Đorđe Lađinović, Mustafa Hrasnica, Santiago Pujol, Schwarz Jochen Bernhard Rudolf, Christoph Butenweg, Mete Sozen, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[r/c frames, masonry infill, behavior, safety, modelling, standardization, framed-masonry]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[In r-c frames infilled with masonry (framed-masonry) the infill walls stiffen the frame and reduce the first-mode period leading to a reduction in drift response to strong ground motion. At the same time, the addition of the masonry wall to the frame tends to increase the base-shear response and reduce the drift capacity of the structure. The increase of lateral force and reduction of drift capacity leads to serious vulnerabilities unless proper proportioning is exercised. For frames with competent walls, the challenge for safe and economical design is to be able to take advantage of the stiffening but to make certain that the increase in lateral forces and reduction in drift capacity do not handicap performance. Available evidence has pointed out that shear strength of the confining column is the &#39;&#39;Achiless&#39;s heel&#39;&#39; of the system. Solution of the problem requires understanding the behavior of masonry and concrete subjected to dynamic and random loading reversals, a challenge that demands testing under reasonably realistic conditions for confident analysis of the problem and its generalization.This is a proposal to investigate the safety and behavior of buildings with masonry-infilled r-c frames through near full-scale dynamic earthquake-simulation tests accompanied by supporting pseudo-dynamic tests of structural assemblies and components and by calibrated analytical solutions. The overall goal is to develop pragmatic methods, by cooperative efforts of team members and co-working international body, for design, safety evaluation and standardization. Because framed-masonry serve both architectural and structural demands efficiently, people in seismic regions live and will continue to live in buildings of this type. An organized solution of the safety of such construction is essential. This proposal intends to put the &#39;&#39;framed-masonry&#39;&#39; composite up as a full-fledged building type, it is &#39;&#39;transformative&#39;&#39; and will change design practice.]]></summary_en></project><project>
<id>1650</id><title_hr><![CDATA[Stvaranje pšenice za budućnost-potraga za novim genima iz postojećih izvora]]></title_hr><title_en><![CDATA[Creating wheat for the future–quest for the new genes in the old gene pool ]]></title_en><user_id>3812</user_id><user_firstLast_name>Sonja Petrović</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2013-11</proposal_call><code>UIP-2013-11-2000</code><acronim><![CDATA[PHENOWHEAT]]></acronim><duration>16.06.2014 - 15.07.2017</duration><status>Završio</status><financ_value>110.558,10 eur</financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Poljoprivreda, </scie_field_hr><scie_field_en>Agriculture, </scie_field_en><institution_hr><![CDATA[Sveučilište Josipa Jurja Strossmayera u Osijeku, Fakultet agrobiotehničkih znanosti Osijek]]></institution_hr><institution_en><![CDATA[Josip Juraj Strossmayer University of Osijek, Faculty of Agrobiotechnical Sciences in Osijek]]></institution_en><team_members_id>381, 5094, 4574, 4054, 5925, </team_members_id><team_members_names><![CDATA[Sonja Marić, Tihomir Čupić, Andrijana Rebekić, Ivana Rukavina , Luka Drenjančević, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[wheat, adaptability, phenotyping, SSR, DArT, association mapping, candidate genes]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Around 20% of human food productions relays on wheat. Climate change evokes new demands for successful wheat breeding such as adaptability to various abiotic stress factors. The most important traits that are affected with climate changes such as drought are yield and quality. Drought tolerance in wheat is quantitative trait with very complex phenotype and genetic control. Significant number of wheat traits has different influence level on drought tolerance. Current global research trend is directed toward development of functional markers linked with wheat adaptability traits. Functional markers are derived from polymorphic sites within the gene that are directly associated with phenotypic variation. Proposed project includes total of 364 wheat accessions originated from five continents. Aims of the project are: assessment of phenotypic and molecular genetic diversity of wheat breeding germplasm; identification of existing functional markers for agronomical important traits in tested germplasm; identification of marker-trait associations; outlining the most suitable parents for future crossing and breeding programs. Project will include phenotyping of traits that are linked with wheat adaptability to drought. This project will contribute to improvement of knowledge of wheat genome research and detection of candidate genes for major marker-traits associations. Knowledge gained through this project will be helpful to better understand genetic control of wheat traits important for adaptation to climate change and drought tolerance. Project will bring out new skills to research group and to research institutions in Croatia by utilisation of DArT markers on wheat for the first time in Croatia. Project will also contribute to wheat selection – research will point out best parents for crossing and it will enable development of new wheat breeding population for further selection and research.]]></summary_en></project><project>
<id>1651</id><title_hr><![CDATA[Mjerenje svojstava Higgsovog bozona i potraga za novom fizikom detektorom CMS]]></title_hr><title_en><![CDATA[The Higgs boson properties measurements and search for new physics with the CMS detector]]></title_en><user_id>4052</user_id><user_firstLast_name>Ivica Puljak</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2013-11</proposal_call><code>IP-2013-11-7118</code><acronim><![CDATA[HIGGSPRO]]></acronim><duration>01.10.2014 - 30.09.2018</duration><status>Završio</status><financ_value>123.129,83 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, </scie_field_hr><scie_field_en>Physics, </scie_field_en><institution_hr><![CDATA[Sveučilište u Splitu, Fakultet elektrotehnike, strojarstva i brodogradnje]]></institution_hr><institution_en><![CDATA[University of Split, Faculty of Electrical Engineering, Mechanical Engineering and Naval Architecture]]></institution_en><team_members_id>6750, 6374, 6738, 6471, 7133, 7481, 7488, 7495, 7563, 19069, 19070, </team_members_id><team_members_names><![CDATA[Damir Lelas, Nikola Godinović, Ilja Doršner, Željko Antunović, Charlot Claude, Marko Kovač, Roberto Salerno, Ochando Christophe, Sirois Yves, Pedro Miguel Ribeiro Cipriano, Toni Šćulac, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[CMS detector, LHC, Higgs boson, leptoquarks, electron reconstruction]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[The discovery of a Higgs boson by the ATLAS and CMS experiments at the LHC has opened a new era for particle physics, namely precision consistency tests of the SM Higgs boson. The proposed project has two main goals: measurement of the SM Higgs boson properties, as the window for the search for new physics beyond the Standard model, and a direct search for new physical phenomena looking for hypothetical particles called leptoquarks. In the first year of project we will explore the data collected by the CMS experiment during 2011 and 2012, while preparing for the LHC Run II, which is expected to start in 2015. Preparation consists of developing and implementing new electron reconstruction, identification and isolation algorithms, which will be used by the whole collaboration when the new data taking starts.  During the second year of the project we will commission and maintain electron reconstruction algorithms, start collecting the data and make first analysis at new energy. During third and fourth year we will explore the data and concentrate to the two main goals of the project: SM Higgs boson properties measurements and search for new physics. ]]></summary_en></project><project>
<id>1667</id><title_hr><![CDATA[Poluvodičke kvantne strukture za napredne sklopove]]></title_hr><title_en><![CDATA[Quantum semiconductor structures for the next generation devices]]></title_en><user_id>627</user_id><user_firstLast_name>Branko Pivac</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2013-11</proposal_call><code>IP-2013-11-6135</code><acronim><![CDATA[QD STRUCTURES]]></acronim><duration>01.06.2014 - 31.05.2018</duration><status>Završio</status><financ_value>88.269,62 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, </scie_field_hr><scie_field_en>Physics, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>2639, 1240, 2934, </team_members_id><team_members_names><![CDATA[Pavo Dubček, Goran Kovačević, Jasna Dasović, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[nanoscience, quantum dots, percolation conductivity, tunneling, photoluminescence, scanning probe microscopy, small angle x-ray scattering, modeling,]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[The fundamental properties of matter are drastically changed due to quantum effects in nanoscopically confined particles. It presents the essence of nanoscience and hence is a cornerstone for the production of advanced materials and devices. The scope of this project is to explore semiconductor nanoparticles in 0-dim, so called quantum dots (QDs), which are the building blocks for advanced materials. We shall study QDs made of different semiconductors embedded in various dielectric materials. The main intention is to explore many of basic physical properties of such systems which are not clear yet and hence prevent their successful development and application. The several key issues that we shall explore are: a) the process of nucleation and growth of QDs, their self-assembly and self-organization. We shall study experimentally and theoretically nucleation growth and crystallinity of different QDs in various dielectrics, and possibility of superstructures formation. Once formed QDs present several serious challenges. The interface QD/dielectric and/or the structure of dielectric layers close to QDs as well as its impact on optical and electrical properties is still completely obscured. In this respect we shall study radiative and nonradiative recombinations of carriers in this region by PL and TRPL. A special effort will be given to theoretical modelling of interfaces, defect formation on such interfaces modeled with molecular dynamics and attempts to describe the transport properties with such modelling. Finally, electronic properties of such composite material will be explored by transport measurements and compared to several simulation models. Several models of unbiased and biased percolation will be explored and applied to this problem. Finally, formation of metal nanoparticles and their plasmonic effect will be explored and analyzed as a special approach to the light management. ]]></summary_en></project><project>
<id>1669</id><title_hr><![CDATA[Matematičko modeliranje i numeričke simulacije procesa u tankim i poroznim sredinama]]></title_hr><title_en><![CDATA[Mathematical modeling and numerical simulations of processes in thin or porous domains]]></title_en><user_id>1462</user_id><user_firstLast_name>Eduard Marušić-Paloka</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2013-11</proposal_call><code>IP-2013-11-3955</code><acronim><![CDATA[MaSiMo]]></acronim><duration>01.07.2014 - 30.06.2018</duration><status>Završio</status><financ_value>68.996,45 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Matematika, </scie_field_hr><scie_field_en>Mathematics, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>3164, 3683, 3254, 3179, 817, 3663, 3424, 5900, </team_members_id><team_members_names><![CDATA[Mladen Jurak, Josipa Pina Milišić, Ana Žgaljić Keko, Anja Vrbaški, Igor Pažanin, Maja Starčević, Andrijana Ćurković, Marija Prša, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[Mathematical modelling,Asymptotic analysis,Numerical simulations,Fluid flow,Homogenization, Boundary layer,Lubrication,Complex fluids,Porous medium]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[We frequently deal with systems described by the differential equations coming from conservation laws that are too complicated to be solved and are of limited use in practice. In many such situations the original physical laws can be replaced by empirical laws or other approximations derived on engineering level of rigor. Mathematical point of view requires justification of those models to see their validity, applicability and accuracy. That can be achieved theoretically by investigating the deviation from the original model, or numerically by comparing simulations with experimental data. Each approach, has its advantages and disadvantages and are, frequently, complementary. In the frame of MaSiMo project we will consider fluid flow through thin domains like pipes and fractures, as well as low permeability domains as porous media.The fluids are either Newtonian or micropolar, monophase or multiphase.  Physical processes in those fluids are convective, diffusive, dispersive or conductive, isothermal  or nonisothermal. Theoretical analysis is based on a priori estimates for governing differential equations, different notions of convergence and compactness. In particular asymptotic analysis and homogenization will be used.  For derivation of a priori estimates a powerful tool is the entropy dissipation method that is considered in this project in the context of nonlinear diffusion and population dynamics problems with a perspective of extension to other considered models. Proposed research is connected to many engineering disciplines, such as mechanical and petroleum engineering, hydrogeology etc. Expected results could improve engineering practice. In Croatian mathematical community  there is a significant  research in this field with several trained scientists. However,  they are dispersed in smaller groups. One of the aims of this project is formation of larger research group with focused scientific interests more competitive in a search for European grants.  ]]></summary_en></project><project>
<id>1672</id><title_hr><![CDATA[Općeslavenski lingvistički atlas (OLA) i Europski lingvistički atlas (ALE)]]></title_hr><title_en><![CDATA[General Slavic Linguistic Atlas (OLA) and European Linguistic Atlas (ALE)]]></title_en><user_id>18899</user_id><user_firstLast_name>Ranko Matasović</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2013-11</proposal_call><code>IP-2013-11-8706</code><acronim><![CDATA[OLAALE]]></acronim><duration>01.09.2014 - 31.10.2018</duration><status>Završio</status><financ_value>72.864,82 eur</financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Filologija, </scie_field_hr><scie_field_en>Philology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Filozofski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Humanities and Social Sciences]]></institution_en><team_members_id>751, 3723, 818, 787, 3726, 2596, 886, 869, 933, 3624, 2984, 3755, 2997, 3415, 3473, 3583, 3659, 5981, 5988, 6131, 5593, 17864, </team_members_id><team_members_names><![CDATA[Mira Menac-Mihalić, Dunja Brozović Rončević, Anđela Frančić, Anita Celinić, Tijmen Pronk, Silvana Vranić, Boris Kuzmić, Mijo Lončarić, Vesna Zečević, Sonja Wölke, Martina Ireinová, Jadwiga Waniakowa, Walentina Rusak, Pavlo Hrytsenko, Gabriela Núcsková, Petra Pradkova, Jana Villnow Komárková, Goran Filipi, Carmen Kenda-Jež, Dubravka Ivšić, Jožica Škofic, Ivana  Štokov, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[dialectology, linguistic atlas, linguistic maps, slavic languages, european languages]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[The “General Slavic Linguistic Atlas” (OLA) and the “European Linguistic Atlas” (ALE) are long-term international linguistic projects. The OLA project involved research material derived from a special survey carried out in 853 settlements, the result of which was an extremely rich dialectological registry. The material collected does not confirm the traditional view of the disintegration of the Proto-Slavic language, instead showing that the disintegration process of the Slavic whole was much more complex. This is seen in isoglosses that cut Slavic territory into the most highly differing directions. This is proof that particular Slavic groups in various historical periods found themselves in complex relationships amongst themselves and that were constantly changing for economic, political, or cultural reasons. Linguistic material for ALE was collected using a special survey carried out in a majority of European countries, including 15 Croatian survey points. The project also involves the etymological and onomasiological interpretation of linguistic material from all European survey points.This project of linguistic atlases provides world dialectology with organised data on the phonetic, phonological, morphological and lexical systems of a large number of languages and dialects, and enables the well-founded study of the linguistic development of European languages. Croatian material is presented and interpreted, and the linguistic relationships between data from the dialects researched is confirmed. Conclusions are drawn on the history and development of languages, on the relationships between them, and thus on the relationships of the Croatian language towards neighbouring and distant dialects. This will provide material for comparative genetic and typological research of linguistic systems in the Slavic and non-Slavic world. These synchronic and diachronic relationships will be presented in the OLA and ALE books and atlases in the form of maps and commentary.]]></summary_en></project><project>
<id>1673</id><title_hr><![CDATA[Pleitropija, genske mreže i putevi u izoliranim ljudskim populacijama: 10.001 Dalmatinac]]></title_hr><title_en><![CDATA[Pleitropy, gene networks and gene pathways in isolated human populations: the 10,001 Dalmatians biobank]]></title_en><user_id>4228</user_id><user_firstLast_name>Ozren Polašek</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2013-11</proposal_call><code>IP-2013-11-8875</code><acronim><![CDATA[10,001 Dalmatians]]></acronim><duration>01.07.2014 - 30.06.2018</duration><status>Završio</status><financ_value>127.599,71 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Javno zdravstvo i zdravstvena zaštita, </scie_field_hr><scie_field_en>Public health and health services, </scie_field_en><institution_hr><![CDATA[Sveučilište u Splitu, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Split School of Medicine]]></institution_en><team_members_id>5251, 5405, 5407, 1358, 19117, 17833, </team_members_id><team_members_names><![CDATA[Ana Miljković, Mirna Kirin, Igor Rudan, Ivana Kolčić, Ajka Relja, Andrea Gelemanović, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[Genomics, anthropometrics, 3 dimensional, exome, analysis]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[This project will investigate how pleitropy (the effect of one gene on multiple phenotypic traits), gene networks and gene pathways are determining a number of clinically relevant quantitative traits. Primary research focus is on the genetic basis of body shape and facial features, based on an innovative approach to produce large number of measurements from the 3-dimensional body and face scanning. In order to achieve this aim, we will perform 3D scanning of 2,000 healthy subjects from the island of Korcula, within one of the largest biomedical research resources in Croatia – the 10,001 Dalmatians biobank. Besides excellent genotyping and sequencing opportunities, the inclusion of subjects from the isolated island populations facilitates gene discovery and enables the search for the rare genetic variants. After completion of genome-wide association and exome analysis, we will also use gene networking and pathway analysis tools, as well as the advanced analytic tools, such as random forest, lasso regression and partial least squares regression in order to produce results that can be translated to clinical medicine, fitness and beauty, as well as legal medicine and forensics. Progress over the existing research designs will also be achieved by inclusion of extensive confounding information and family structure into analysis. All these findings will also be investigated in follow-up measurements and linked with the morbidity and mortality information in the future, thus further developing a coherent resource capable of producing highly competitive research results. With the excellent track record of the principal investigator, outstanding institutional support and well-established research team experienced in computational genomics and field work, this project will provide a substantial step forward over the existing state-of-the-art studies that rely on simple genomic associations, yet manage to publish their results in the top-end journals. ]]></summary_en></project><project>
<id>1674</id><title_hr><![CDATA[Starosno-ovisna ekspresija membranskih prijenosnika u štakora]]></title_hr><title_en><![CDATA[Aging-related expression of membrane transporters in rat]]></title_en><user_id>179</user_id><user_firstLast_name>Davorka Breljak</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2013-11</proposal_call><code>IP-2013-11-1481</code><acronim><![CDATA[AGEMETAR]]></acronim><duration>01.10.2014 - 31.03.2019</duration><status>Završio</status><financ_value>132.722,81 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Institut za medicinska istraživanja i medicinu rada]]></institution_hr><institution_en><![CDATA[Institute for Medical Research and Occupational Health]]></institution_en><team_members_id>200, 226, 951, 221, 128, 216, 201, 343, 1099, 87, 171, 1396, 19039, 126, </team_members_id><team_members_names><![CDATA[Marija Ljubojević, Ivana Vrhovac, Dean Karaica, Vedran Micek, Jasna Jurasović, Tatjana Orct, Maja Peraica, Dubravka Rašić, Ivana Novak Jovanović, Goran Gajski, Marko Gerić, Ivica Rubelj, Lucia Nanić, Ivan Sabolić, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[aging, antioxidants, drug transporters, hepatotoxicity, liver, kidney, Klotho, membrane transporters, nephrotoxicity, oxidative stress,  telomeres ]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Aging is a physiological process characterized by a gradual decline in physical fitness and other functional capabilities. The mechanisms of aging and possible actions of slowing down or ameliorating aging-related processes are poorly understood. In humans, one of the characteristics of old age is polypharmacy, which elevates risks of drug-drug interactions and drug-induced adverse reactions and organ toxicity, such as hepatotoxicity and nephrotoxicity. These reactions may partially result from diminished drug metabolism and/or mainly from impaired activity/expression of various membrane transporters that are responsible for drug excretion in liver and kidneys. These both mechanisms have been poorly studied in senescent organs. Here we promote a hypothesis that the aging-induced oxidative stress, known to downregulate the activity/expression of the aging suppressor gene (Klotho) and to shorten the length of telomeres, also diminishes the activity/expression of various membrane transporters in liver and kidneys, and that these changes can be ameliorated by treating animals with antioxidants resveratrol and melatonin. The extent and the intensity of aging-related changes, and the beneficial effects of antioxidants may be sex-related. To test this hypothesis, we propose various biochemical and cell- and molecular-biological studies of aging parameters and aging-dependent expression of various membrane transporters in the mammalian liver and kidneys using a rat model of experimental aging. Possible aging-related decline in the expression of these transporters may explain a higher incidence (women > man) of drug interactions and toxicity in old people. The studies will define the underlying cellular mechanisms that contribute to generation of the aging-related pathophysiological conditions in the liver and kidneys, and will indicate possible ways of their amelioration. Positive results may point to remedies to be used for improving the health of elderly people.]]></summary_en></project><project>
<id>1680</id><title_hr><![CDATA[Ekološki pristup projektiranju broda i optimalnom planiranju rute]]></title_hr><title_en><![CDATA[Greener Approach to Ship Design and Optimal Route Planning]]></title_en><user_id>4256</user_id><user_firstLast_name>Jasna Prpić-Oršić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2013-11</proposal_call><code>IP-2013-11-8722</code><acronim><![CDATA[GASDORP]]></acronim><duration>20.07.2014 - 19.07.2018</duration><status>Završio</status><financ_value>131.926,47 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Brodogradnja, </scie_field_hr><scie_field_en>Naval architecture, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Tehnički fakultet]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Engineering]]></institution_en><team_members_id>4179, 3868, 2951, 4580, 4658, 4890, 5599, 5931, 5403, 19041, </team_members_id><team_members_names><![CDATA[Duško Pavletić, Tomislav Mrakovčić, Marko Valčić, Roko Dejhalla, Dunja Matulja, Odd Magnus Faltinsen, Ozren Bukovac, Nikola Račić, Igor Rudan, Natalija Vitali, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[seakeeping, ship speed, ship resistance, ship propulsion, fuel consumption, GHG emission, weather routing]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[The accurate calculation of attainable ship speed at actual sea is essential from economical and also environmental aspects. Reliable ship speed loss estimation under real environmental conditions allows a more accurate prediction of the power increase and fuel consumption as well as gas emissions from ships. Nowadays this second issue becomes very important because of the problem of global warming. Following the increasing awareness of the environmental and human health concerns of shipping, legislative actions have been taken on global and national levels making mandatory (from January 1st 2013) that new ships over 400 gross tonnage, to comply with the regulations, should have emissions of CO2 under limiting value. Technological enhancement to ships like improved hull designs as well as improvement in power and propulsion systems could potentially reduce CO2 emission up to 35 %. These measures could effectively be combined with several other operational measures, such as weather routing and voyage planning, in order to ensure that fuel consumption and CO2 emissions from ships are minimized on every voyage.The proposed research will be conducted in three main areas: 1. Improvement of the methodology of ship speed, fuel consumption and greenhouse gases (GHG) emissions (especially CO2) calculation on actual weather conditions, 2. Optimization of the ship hull (bow and stern) and ship propulsion system operating in actual weather condition, 3. Optimization of ship route by taking into account all relevant parameters: weather prediction, attainable ship speed on waves, main engine performance and navigation constrains. The objective is to improve ship design and performance taking into accounts the environmental issue, creating a so called eco-efficient or “green” ship design. The project team consists of the scientists who are experts in the naval architecture, mechanical engineering and marine engineering field which allow solving this problem multidisciplinary. ]]></summary_en></project><project>
<id>1682</id><title_hr><![CDATA[Genetska osnova količne bioaktivnih hranivih tvari hrvatskih populacija graha]]></title_hr><title_en><![CDATA[Genetic basis of bioactive nutrient content in Croatian common bean landraces]]></title_en><user_id>1294</user_id><user_firstLast_name>Klaudija Carović-Stanko</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2013-11</proposal_call><code>UIP-2013-11-3290</code><acronim><![CDATA[BeanQual]]></acronim><duration>16.06.2014 - 15.06.2017</duration><status>Završio</status><financ_value>121.674,44 eur</financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Poljoprivreda, </scie_field_hr><scie_field_en>Agriculture, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Agronomski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Agriculture]]></institution_en><team_members_id>770, 6287, 3338, 4953, 5513, 5829, 4927, 4954, 3037, 17838, 12601, </team_members_id><team_members_names><![CDATA[Zlatko Liber, Jerko Gunjača, Mirjana Herak Ćustić, Marko Petek, Martina Grdiša, Ivan Radosavljević, Tomislav  Karažija, Boris Lazarević, Igor Palčić, Monika Vidak, Ana Barešić, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[Phaseolus vulgaris L., nutrients, bioactive substances, molecular markers, genetic diversity, association mapping]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Common bean is a valuable legume for human consumption worldwide, being an important source of proteins, vitamins and minerals with considerable potential as a functional food. However, the increased mineral content in the diet does not guarantee increased mineral status for consumers and consequently mineral malnutrition is one of the global health concerns. Phytic acid (PA) acts as antinutritive compound by binding mineral cations and forming mixed salts. PA is also the main storage molecule for phosphorus and it is essential for normal seed development and germination. Seed mineral and PA content varies widely among bean genotypes. In Croatia bean is traditionally grown in low input production systems. The production is based on landraces which are adapted to local environments and display high levels of morphological diversity. A broad variability is also expected in seed bioactive nutrient content as well as on genetic level. Through international collaboration on Phaseolus genomics, a lot of information has become available including genetic linkage maps, microsatellite databases and a massive number of single nucleotide polymorphisms (SNP) sequences. In proposed project an integrated approach will be used to characterize bioactive nutrient variability and the inherent genetic diversity. In conjunction with a detailed data on bioactive nutrient content, a whole genome association mapping analysis will be carried out in order to identify quantitative trait loci (QTLs) related to bioactive nutrient content. Success in bean breeding for higher quality relies on the availability of information on bioactive nutrient content and the knowledge of genetic bases of quality trait variability. The integration of fundamental (molecular genetics) and applied (plant nutrition, plant breeding) sciences will facilitate the management of traditional landraces as sources of bioactive nutrients in future breeding programs based on marker-assisted selection (MAS).]]></summary_en></project><project>
<id>1683</id><title_hr><![CDATA[Rekonstrukcija okoliša u Hrvatskoj tijekom kvartara primjenom izotopnih metoda]]></title_hr><title_en><![CDATA[Reconstruction of the Quaternary environment in Croatia using isotope methods]]></title_en><user_id>1168</user_id><user_firstLast_name>Ines KRAJCAR BRONIĆ</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2013-11</proposal_call><code>IP-2013-11-1623</code><acronim><![CDATA[REQUENCRIM]]></acronim><duration>01.09.2014 - 30.11.2018</duration><status>Završio</status><financ_value>132.676,06 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Geologija, </scie_field_hr><scie_field_en>Geology, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>353, 3702, 3367, 1159, 1343, 1413, 3789, 1324, 3115, 3097, 4142, </team_members_id><team_members_names><![CDATA[Nada Horvatinčić, Tatjana Bakran-Petricioli, Sanja Faivre, Jadranka Barešić, Maša Surić, Neven  Bočić, Andreja Sironić, Robert Lončarić, Nenad Buzjak, Nina Lončar, Iva Babić, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[paleoclimate, paleoenvironment, Quaternary, speleothem, algal rim, tufa, lake sediment, stable isotopes, 14C dating, U-Th series dating]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Interdisciplinary scientific study of paleoclimate and paleoenvironment is of the great importance for prediction of future climate and environmental changes. Croatia occupies a key position between eastern and western Mediterranean basins and delimits central European and the Mediterranean regions influenced by different climates. Dinaric karst, covering half of the Croatian territory, offers exquisite potential for such a research, having the wide range of karstic forms already proven as good (paleo)environmental archives, such as terrestrial and submerged speleothems, tufa deposits and lake sediments in karstic lakes and marine algal rims in the coastal area. Within this research various carbonate sediments from different climate zones will be studied: speleothems from 3 locations in littoral Croatia, mountainous Gorski Kotar region and central Croatia, lake sediments from Plitvice Lakes, tufa deposits from Zrmanja River, and marine algal rims from ~8 locations along the eastern Adriatic coast. Research will be based on isotopic methods that include analyses of stable isotope ratios 13C/12C and 18O/16O in carbonate deposits, 2H/1H and 18O/16O in water, and radioactive isotopes 14C and U-Th series for dating. Stable isotopes in carbonates will provide information about past environmental conditions, temperature variations, lake evaporation, bioactivity and productivity, and indicate the origin of carbon and mechanisms of calcite precipitation. Algal rims serve as good and precise sea-level indicators and additionally their morphology, age and stable isotope composition could be directly linked to climate changes.The expected outcome is the estimation of regional response of the environment in Croatia to global changes during the Quaternary, and of differences in response of various carbonates to paleoenvironmental changes and their correlations.The project combines groups from Ruđer Bošković Institute, Faculty of Science (Univ. of Zagreb), and University of Zadar.]]></summary_en></project><project>
<id>1687</id><title_hr><![CDATA[Zaštita privatnosti deidentifikacijom u nadzornim sustavima ]]></title_hr><title_en><![CDATA[De-identification for Privacy Protection in Surveillance Systems  ]]></title_en><user_id>4290</user_id><user_firstLast_name>Slobodan Ribarić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2013-11</proposal_call><code>IP-2013-11-6733</code><acronim><![CDATA[DePPSS]]></acronim><duration>01.10.2014 - 30.09.2018</duration><status>Završio</status><financ_value>81.633,69 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Računarstvo, </scie_field_hr><scie_field_en>Computer sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id>4689, 4593, 20381, 20383, 4584, </team_members_id><team_members_names><![CDATA[Branko Samaržija, Marijo Maračić, Vitomir  Štruc, Darko Mihalić, Darijan Marčetić, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[privacy protection, biometric identification, de-identification, surveillance systems, video ]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Owing to advances of video surveillance systems it is possible, besides detection of people&#39;s behavioural anomalies, by using of reliable recognition software to perform identification and simultaneously trace people in the real time. Whilst it is recognized that there are justified reasons for acquisition and sharing videos in manners such as security, bio-terrorism surveillance applications, low enforcement and forensics, there is also a strong need for protecting the privacy of the guiltless individuals who are inevitably captured in the recordings. Video surveillance is privacy intrusive because it allows the observation of certain information that is considered privacy intrusive. Face has central role in the process of human recognition and identification in videos, thus the special attention has to be devoted to the face de-identification methods for privacy protection. De-identification addresses, in context of our project, the automated methods of concealing or/and removing face identifiers of individuals captured in videos. The importance of privacy protection is mirrored in documents such as UN Universal Declaration of Human Rights, and EU’s Data Protection Directive (95/46/EC) as well as commissioned review of the Data Protection Directive (95/46/EC) by the EU Information Commissioner’s Office from July 2008. The general public has become increasingly aware of the potential danger for their personal data to be abused.Beside scientific objectives and goals (robust face localization, novel methods for face de-identification in videos, preserving data utility and naturalness in de-identification videos, privacy protection), the main objectives of the proposed project are human resources (early stage researchers and PhD students) development by transfer of knowledge in the fields of advanced technologies to carry out problem-oriented research, and increasing a competitiveness level of the research team for Horizon 2020 project applications. ]]></summary_en></project><project>
<id>1690</id><title_hr><![CDATA[Klasifikacija i objašnjenja antisocijalnog poremećaja osobnosti i moralna i kaznena odgovornost u kontekstu Hrvatskog zakona o mentalnom zdravlju i skrbi]]></title_hr><title_en><![CDATA[Classification and explanations of antisocial personality disorders and moral and criminal liability within the context of Croatian mental health law and care]]></title_en><user_id>4121</user_id><user_firstLast_name>Luca Malatesti</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2013-11</proposal_call><code>IP-2013-11-8071</code><acronim><![CDATA[CEASCRO]]></acronim><duration>01.09.2014 - 31.08.2018</duration><status>Završio</status><financ_value>42.232,40 eur</financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Filozofija, </scie_field_hr><scie_field_en>Philosophy, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Filozofski fakultet u Rijeci]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Humanities and Social Sciences]]></institution_en><team_members_id>2985, 4704, 4172, 3788, 4815, 6425, 7394, 7077, 4401, 2875, 22814, </team_members_id><team_members_names><![CDATA[Vesna  Šendula Jengić, Predrag Šustar, Marko Jurjako, Zdenka Brzović, John McMillan, Filip Čeč, Mariastella  Pulvirenti, Vanni D&amp;#39;Alessio, Jelena Hodak, Dalida Rittossa, Karge Heike, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[antisocial personality disorders, psychiatric classification,  psychiatric explanation, moral responsibility,  Croatian mental health law and care]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[This interdisciplinary project investigates the problem of the social response in Croatia to a class of offenders classified as having antisocial personality disorders. The core methodology consists in  conducting philosophical investigations that are aimed at offering practical recommendations and that are constrained by knowledge of the practical setting of Croatian mental health law and care.  Two central philosophical issues appear to be relevant to the philosophical investigation and, thus, addressing them  is the aim of the project. First, a significant part of the contemporary debate on the social response to antisocial personality disorder centers on this notion. Some have argued that this notion involves normative preconceptions  against the liberties of certain individuals. Others have questioned the accuracy and scientific robustness of the diagnosis of antisocial personality disorders and its precision of related risk predictions.  Second, the justification for choosing the appropriate treatment for people with antisocial personality disorder must also be a moral one. In particular, a relevant type of moral justification has to be grounded in principles that correlate psychological descriptions and explanations of a person’s behavior with his or her degree of responsibility.  Similarly, compulsory treatment appears to be conditional upon a person’s diminished responsibility or capacity to act accordingly to a treatment decision, together with the existence of a risk to themselves or to others.The philosophical investigation of the project will be integrated with the contributions of  a leading forensic psychiatrist in Croatia, a sociological qualitative analysis of the practices and challenges that are encountered by institutional representatives in the forensic department of the Rab psychiatric hospital and an historical investigation of the institutional response to antisocial personality disorder in the region in the period 1918-1980.]]></summary_en></project><project>
<id>1697</id><title_hr><![CDATA[Održiva proizvodnja bioetanola i biokemikalija iz otpadnih poljoprivrednih lignoceluloznih sirovina]]></title_hr><title_en><![CDATA[Sustainable production of bioethanol and biochemicals from agricultural waste lignocellulosic raw materials ]]></title_en><user_id>4332</user_id><user_firstLast_name>Božidar Šantek</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2013-11</proposal_call><code>IP-2013-11-9158</code><acronim><![CDATA[SPECH-LRM]]></acronim><duration>01.09.2014 - 31.08.2018</duration><status>Završio</status><financ_value>127.413,90 eur</financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Biotehnologija, </scie_field_hr><scie_field_en>Biotechnology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prehrambeno-biotehnološki fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Food Technology and Biotechnology]]></institution_en><team_members_id>5761, 5778, 5039, 4314, 3709, 4912, 6032, 450, 4102, 4098, 4100, 4321, 4324, 5414, 4450, 4544, 4437, 4438, 4430, 17840, 23620, </team_members_id><team_members_names><![CDATA[Predrag Horvat, Srđan Novak, Vesna  Zechner-Krpan, Anita Slavica, Vlatka Petravić Tominac, Sunčica Beluhan, Mirela Ivančić Šantek, Tonči Rezić, Mladen Pavlečić, Antonija Trontel, Mario Novak, Ivan-Krešimir Svetec, Anamarija Štafa, Marina Miklenić, Bojan Žunar, Draženka Komes, Ana Belščak-Cvitanović, Aleksandra  Vojvodić, Arijana Bušić, Martina Andlar, Nenad Marđetko, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[bioetahnol, lactic acid, physiological active oligosaccharides, lignocellulosic raw materials, integrated bioprocess, mathematical modeling, LCA]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[The aim of this project proposal is the development of sustainable bioprocesses for the production of bioethanol and biochemicals [lactic acid (LA) and physiologically active oligosaccharides (PAO)] from agricultural waste lignocellulosic raw materials (e.g. wheat straw, corn stover and cob, onion peels, cocoa husks, pea pods, walnut shells and sugar beet pulp). All these agricultural byproducts are abundant, cheap, non-food competing and renewable polysaccharide-based feedstocks.  In this project, agricultural waste lignocellulosic raw materials will be hydrolyzed by thermal, chemical or enzymatic methods or their combinations in order to obtain adequate disintegration of raw materials. Studies of bioethanol and LA production will be performed by the semi-solid or solid state fermentation in the new constructed horizontal rotating tubular bioreactor (HRTB). The most suitable microorganisms for bioetahnol and LA production will be identified and improved by genetic methods. Studies regarding suitable purification methods for all three bio-products will be performed in order to obtain pure compounds for theirs further practical use. Integration between production and separation bioprocess stages will be also examined in order to improve ecological and economical aspects of these bioprocesses. The sustainability of bioethanol and LA production will be evaluated through the realization of Life Cycle Assessment (LCA). The most efficient and sustainable bioprocess configuration will be determined and consequently scale-up procedure will be proposed. The scale-up procedure will be based on the developed integral bioprocess mathematical model and other scale-up criteria. Project outcomes will be new integrated bioprocesses for the transformation of agricultural waste lignocellulosic raw materials into high added value products.]]></summary_en></project><project>
<id>1699</id><title_hr><![CDATA[Klima jadranske regije u njenom globalnom kontekstu]]></title_hr><title_en><![CDATA[Climate of the Adriatic REgion in its global context]]></title_en><user_id>3375</user_id><user_firstLast_name>Mirko Orlić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2013-11</proposal_call><code>IP-2013-11-2831</code><acronim><![CDATA[CARE]]></acronim><duration>01.07.2014 - 30.06.2018</duration><status>Završio</status><financ_value>116.291,72 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Geofizika, </scie_field_hr><scie_field_en>Geophysics, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>4069, 2552, 2840, 1265, 2650, 1315, 2898, 1417, 2655, 2635, 1121, 3146, 2839, </team_members_id><team_members_names><![CDATA[Čedomir Branković, Ksenija Cindrić, Marjana Gajić-Čapka, Ivan Güttler, Ivana Herceg Bulić, Iva Međugorac, Miroslava Pasarić, Zoran Pasarić, Mirta Patarčić, Melita Perčec Tadić, Renata Sokol Jurković, Lidija Srnec, Ksenija Zaninović, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[Adriatic, climate change, extremes, climate models, downscaling, spatial interpolation, sea-level trend, coastal flooding, sea-level projections]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Temporal and spatial statistical analysis of climatological variables will be performed, with the emphasis on the multidecadal changes in temperature and precipitation indices of extremes in the Adriatic region. Particular attention will be paid to the analysis of drought, floods and heat waves. Possible change in climate suitability for tourism will be investigated. The obtained gridded fields will become a reference data for the validation of climate models and an input into the flash-flood warning systems. Current and future climate of the Mediterranean area will be examined by analyzing the results of global-model simulations and by using the statistical and dynamical downscaling approach. Simulations by RegCM4.2 regional climate model will be performed at the horizontal resolution of 12.5 km. Also planned is to utilize results from experiments based on coupled atmosphere-ocean models from the currently running Med-CORDEX project with a purpose of analyzing the contribution of oceanic component in the simulations over the Adriatic Sea and the surrounding land area. Trends and interdecadal variability of sea level in the Mediterranean sub-basins will be identified and contributions of the governing processes will be assessed. Coastal flooding in the Northern Adriatic and time evolution in occurrence of extreme sea levels in the context of mean-sea-level rise will be considered. Finally, older variants of semi-empirical method of projecting global sea level will be compared with the more general method recently developed. It is expected that the project thus considered will meet the three important criteria (relevance, reliability, feasibility), by addressing one of the few priorities put forward by the European Union in its growth strategy Europe 2020, by relying on the state-of-the-art methods of data analysis and modeling, and by involving a majority of researchers engaged in the study of climate-related physical processes in Croatia.]]></summary_en></project><project>
<id>1703</id><title_hr><![CDATA[Jako korelirani elektroni u slojnim organskim materijalima i manganitima: niskofrekventna pobuđenja i nelinearna dinamika]]></title_hr><title_en><![CDATA[Strongly  Correlated Electrons in Layered Organics and Manganites: Low Frequency Excitations and Non-linear Dynamics]]></title_en><user_id>2680</user_id><user_firstLast_name>Silvia Tomić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2013-11</proposal_call><code>IP-2013-11-1011</code><acronim><![CDATA[SCEinLOM]]></acronim><duration>01.06.2014 - 31.07.2018</duration><status>Završio</status><financ_value>128.316,98 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, </scie_field_hr><scie_field_en>Physics, </scie_field_en><institution_hr><![CDATA[Institut za fiziku]]></institution_hr><institution_en><![CDATA[Institute of Physics in Zagreb]]></institution_en><team_members_id>1433, 2708, 2752, 3073, 3184, 2842, 3352, 17776, 21185, </team_members_id><team_members_names><![CDATA[Amir Hamzić, Mario Basletić, Emil Tafra, Bojana Hamzić, Tomislav Ivek, Matija Čulo, Marko Pinterić, Branimir Mihaljević, David Rivas Góngra, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[correlated electrons, unconventional superconductivity, colossal magnetoresistance, charge and spin orderings, quantum spin liquids, nonlinear effects]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Strongly correlated electrons in solids generate broken symmetry phases and collective excitations that are fundamental to our understanding of the most intriguing properties of quantum matter. Phase diagrams of layered cuprate, organic superconductors and manganites, as well as some other transition-metal systems, famous for the phenomena of unconventional superconductivity (SC) and colossal magnetoresistance (CMR), respectively feature an extraordinary complexity of electronic phases, which can be tuned by chemical composition, magnetic field and pressure. A prominent place among these phases is held by stripes, patterns of charge order (CO), which are thought to be linked to SC and CMR, as well as by CO phases with ferroelectric signatures due to a rich variety of nonlinear properties and complex dynamics. Despite intense research efforts, these basic issues in condensed matter physics bear many open questions. We propose to investigate the nature of charge/spin-ordered phases and their motion developed in series of organic and transition metal solids applying modern experimental tools available at the Institute of Physics, Zagreb and at the Department of Physics, Faculty of Science, University of Zagreb (dielectric spectroscopy, pulsed nonlinear conductivity, ac/dc resistance, magnetoresistance and Hall effect).  Our overall contributions to the field and our expertise in condensed matter physics have been internationally recognized. Together with the available experimental means, this positions us as researchers fully suitable and competent for the proposed task. Our international partners will give an added value with samples, experiments and expertise in the terahertz and infrared spectroscopy. Integrated students and postdocs are going to acquire advanced skills in the materials science and learn to solve complex problems in a collaborative environment. Results will be published in international scientific journals and presented at international conferences.]]></summary_en></project><project>
<id>1706</id><title_hr><![CDATA[Kruženje sumpora i ugljika u morskom i slatkovodnom okolišu]]></title_hr><title_en><![CDATA[The Sulphur and Carbon Dynamics in the Sea- and Fresh-Water Environment]]></title_en><user_id>287</user_id><user_firstLast_name>Irena  Ciglenečki-Jušić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2013-11</proposal_call><code>IP-2013-11-1205</code><acronim><![CDATA[SPHERE]]></acronim><duration>01.09.2014 - 31.08.2018</duration><status>Završio</status><financ_value>128.920,89 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, </scie_field_hr><scie_field_en>Chemistry, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>561, 989, 454, 290, 278, 1155, 84, 17873, </team_members_id><team_members_names><![CDATA[Elvira Bura-Nakić, Nevenka Mikac, Palma  Orlović-Leko, Marija Marguš, Milan Čanković, Jelena Dautović, sanja frka milosavljević, Ana  Cvitešić, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[sulphur speciation, organic matter properties, nanoparticles in water environment, aerosols, global climate changes, extreme events, euxinia  ]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[The SPHERE aims to study sulphur (S) and carbon (C) dynamics between different environmental compartments (atmosphere, water, sediment, biota) of the sea- and fresh-water environment including distribution between organic, inorganic, dissolved, colloidal and nanoparticulate fractions. S and C cycles in the aqueous environment are recognized as important factors for regulating global climate. Nowadays, human activities have vastly affected the S and C cycles. The aquatic ecosystem responses to likely changes in physical, chemical and socio-economic forcing induced by global climate changes, including warming, acidification, biodiversity modifications as well changes in frequency of extreme events (flooding, dust input, hypoxia-anoxia appearance) and by growing anthropogenic pressures will be considered under SPHERE. Effects of the main natural and anthropogenic forcing (extreme events, eutrophication, global changes) related with S and C dynamics will be studied.The SPHERE objectives are: 1) testing and improving existing methods and development of new methods essential for S and organic matter (OM) characterization in water and atmospheric environment; 2) to estimate exchanges and interactions of S and C with other natural and potentially toxic trace elements within and between the major environmental compartments; 3) to monitor and couple S and C dynamics under extreme events (stratification-destratification, hypoxia-anoxia, extreme atmospheric inputs); 4) to synthesize all obtained data for assessment of ecosystem vulnerability and ecological status, in line with water framework directive and national strategy. The SPHERE will be implemented in the period of 4 years through 5 workpackages: 1) OM properties and dynamics; 2) S speciation and dynamic; 3) S, C interaction with trace metals and importance of chalcogenide nanoparticles; 4) thermodynamic predictions for S and C distribution and dynamics; 5) project management.]]></summary_en></project><project>
<id>1715</id><title_hr><![CDATA[Primjena matematičkog modeliranja i inteligentnih algoritama pri konstrukciji odjeće]]></title_hr><title_en><![CDATA[Application of mathematical modelling and intelligent algorithms in clothing construction]]></title_en><user_id>42</user_id><user_firstLast_name>Tomislav Rolich</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2013-11</proposal_call><code>IP-2013-11-3011</code><acronim><![CDATA[AMMIACC]]></acronim><duration>01.10.2014 - 30.09.2018</duration><status>Završio</status><financ_value>54.801,25 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Računarstvo, </scie_field_hr><scie_field_en>Computer sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Tekstilno-tehnološki fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Textile Technology]]></institution_en><team_members_id>4302, 1095, 5086, 7420, 4325, </team_members_id><team_members_names><![CDATA[Slavica  Bogović, Daniel Domović, Jacqueline Domjanic, Zoran Stjepanovič, Slavenka Petrak, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[intelligent algorithms, mathematical modelling, packaging, optimization, automatic marker-making, clothing construction, geometric morphometry]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[In the project it is intended to develop new computer programs based on mathematical modelling and intelligent algorithms. Scope of computer programs is an area of clothing construction, and therefore data from measurements and scanning using 3D body scanners will be collected. For the analysis of digitized data of human body, data acquisition of static and dynamic anthropometry will be collected and then processed with geometric morphometry and PCA methods. In that way data of shapes and sizes that cannot be acquired with the usual methods of measurement and data processing will be obtained. Based on these data new methods of construction will be developed, for which the most applicable methods of mathematical modelling will be defined. Intelligent algorithms will be used for solving problems related to the automatic marker making, where solutions to specific problems and conditions that must be met for that purpose will be found.Using distinctive interdisciplinary approach computer programs will be developed for the purpose of construction of specific garment that is not common in our market such as overalls for professional sports, diving suits or clothes that is used for medical purposes (compression garments, etc.), and protective clothing. The development of software applications will be based on scientific knowledge, and it also can have its practical application in the manufacture of clothing. In cooperation with industry, garments could be developed that are not in everyday use and for which there is a need in the domestic and foreign markets.]]></summary_en></project><project>
<id>1716</id><title_hr><![CDATA[Nekovalentne interakcije u dizajnu novih fotoosjetljivih molekula]]></title_hr><title_en><![CDATA[Non-covalent interactions in design of novel photosensitive molecules ]]></title_en><user_id>243</user_id><user_firstLast_name>Davor Margetić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2013-11</proposal_call><code>IP-2013-11-9310</code><acronim><![CDATA[NoncoPhoto]]></acronim><duration>01.09.2014 - 31.08.2018</duration><status>Završio</status><financ_value>122.863,28 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, </scie_field_hr><scie_field_en>Chemistry, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>3939, 368, 4851, 566, 963, 17759, </team_members_id><team_members_names><![CDATA[Vjekoslav Štrukil, Zoran Glasovac, Anamarija Briš, Ivana Antol, Tomislav Portada, Mateja Đud, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[physical-organic chemistry, green chemistry, synthesis, computational chemistry, organic materials]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Project addresses two key research objectives in the European Union: energy and environment conservation. The scientific approach is based on a combination of theoretical and experimental knowledge and experience of collaborators, and includes quantum-chemical calculations and molecular modelling in the molecular design, chemical synthesis and physico-chemical characterisation of molecules.The aim of project is to study fundamental physico-chemical properties of supramolecular systems built by non-covalent interactions (NC) - hydrogen bonding and metal-ligand coordination. The objectives are: a) Synthesis and structural characterization of functionalized bis-chromophoric molecular systems possessing guanidine, (thio)urea and carboxylate functionalities by employment of novel environmentally friendly synthetic methods; b) Detailed insight into the fundamental mechanisms how NC bonds mediate excited energy-transfer processes from one chromophore to another within assemblies; c) Analysis of influence of guanidine and (thio)urea functionalities and their anion complexation on the spectroscopic properties; d) Study of novel assemblies based on NC interactions and influence of different media; e) Development of model heterogeneous photo-responsive catalysis materials; f) Construction of complex multichromophoric supramolecular assemblies.Results of fundamental studies carried out within this project will enrich the understanding of physico-chemical factors in electron transfer processes in supramolecular systems constructed of chromophoric pairs employing the non-covalent bonding. Expected results will enable design of novel photoactive systems which could be applied in the technological development including sensors, fluorescent probes in biomedicine, organic photovoltaics, molecular electronics and heterogeneous catalysis.]]></summary_en></project><project>
<id>1718</id><title_hr><![CDATA[Nuklearna struktura i reakcije: eksperimentima prema neutronskoj liniji kapanja]]></title_hr><title_en><![CDATA[Nuclear structure and reactions – experiments towards the neutron drip line ]]></title_en><user_id>166</user_id><user_firstLast_name>Suzana Szilner</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2013-11</proposal_call><code>IP-2013-11-7194</code><acronim><![CDATA[SR-ETNo]]></acronim><duration>01.09.2014 - 31.10.2018</duration><status>Završio</status><financ_value>126.651,11 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, </scie_field_hr><scie_field_en>Physics, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>193, 257, 4019, 414, 185, 255, 163, 24613, </team_members_id><team_members_names><![CDATA[Deša Jelavić Malenica, Tea Mijatović, Matko Milin, Neven Soić, Milivoj Uroić, Mile Zadro, Igor Gašparić, Romana Popočovski, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[nuclear structure, nuclear reactions, neutron-rich nuclei, nucleon-nucleon correlations, nuclear pairing, nuclear clustering]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Understanding of atomic nuclei relies on knowledge about interaction between their components and details of their relationship. Recent advent of detector arrays allows systematic studies of nuclei away from the region of nuclear stability. With the proper selection of colliding systems and reaction energies, the exchange of nucleons can lead to the population of neutron-rich nuclei, peculiar systems having challenging aspects in their nuclear structure behaviour. The main objective of this research project is to advance understanding of the nuclear reactions and structure in the vicinity of the neutron drip line. By the use of the new generation instrumentation, we will experimentally study three different neutron-rich groups of nuclei: very heavy nuclei (difficult to access experimentally with other methods), medium-mass nuclei (where well known magic numbers disappear), and finally, lower mass nuclei (were the neutron drip line has already been experimentally reached). The major part of the proposed experimental work will be performed at the top international accelerator facilities, but in the well suited cases, the measurements will be performed at the RBI accelerator. The new experimental data will significantly improve our understanding of nuclei far from the stability line and will have a considerable impact on the reaction measurements at next generation of the radioactive beam facilities. Scientists involved in this project are active members of a number of  leading international collaborations in the field, with large experience in experimental research and considerable international reputation. Project PI has remarkable research track record and has led a successful project before. Senior scientists on the project have led a number of competitive projects (funded by MSES, FP7, ESF and Croatian SF). Finally, this project is well integrated with the strategic community document Long Range Plan of the Nuclear Physics European Collaboration Committee.]]></summary_en></project><project>
<id>1721</id><title_hr><![CDATA[Poslovna i osobna insolventnost - putevi izlaska iz prezaduženosti]]></title_hr><title_en><![CDATA[Business and Personal Insolvency - the Ways to Overcome Excessive Indebtedness]]></title_en><user_id>4238</user_id><user_firstLast_name>Mira Dimitrić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2013-11</proposal_call><code>IP-2013-11-6558</code><acronim><![CDATA[BPII]]></acronim><duration>01.07.2014 - 30.06.2018</duration><status>Završio</status><financ_value>39.576,61 eur</financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Ekonomija, </scie_field_hr><scie_field_en>Economy, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Ekonomski fakultet]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Economics and Business]]></institution_en><team_members_id>4370, 6745, 5495, 5884, 2915, 5117, 5618, 5867, 6706, 5536, 17867, </team_members_id><team_members_names><![CDATA[Ivana Tomas Žiković, Dunja Škalamera-Alilović, Andrea Arbula Blecich, Tomislav Ćorić, Saša Žiković, Dejan Bodul, Branka Crnković-Stumpf, Predrag Bejaković, Jana Katunar, Nikolina Dukić, Sonja Brlečić Valčić, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[Business Insolvency, Personal Insolvency, Indebtedness, Bankruptcy Law, Restructuring]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Project proposal targets the vital problem of contemporary economic reality and science: insolvency and excessive indebtedness. The goal is to shed light and to interconnect different views of the problem, therefore deepening the understanding of the subject area, and offer preventive and curative solutions. This is necessary because insolvency, on business level, disables development and adequate business and financial restructuring, on personal level it destroys an individual and a family, whereas at social level it creates poverty and enhances negative economic trends. Goals are aimed at: different levels of the principal groups of insolvency and over-indebtedness actors, which are: business, personal and public level, and at business environment as a platform for finding better indebtedness management possibilities. The results of the business level research should significantly improve the prediction possibilities of financial distress and enable larger time-opportunity-window to exploit different restructuring options. Also, the results should provide the scientific knowledge of such financial management that would encourage business development by financial leverage and not threaten the survival of business entities because of the inadequate capital structure. The results of the personal level research should make way to the widespread alteration of approach to new debt. New personal finance culture pattern is expected to be backed by these results and should emerge both among individuals (as demand force of debt), and financial institutions (as supply force of debt). Project proposal is directed toward the research of four distinctive segments of business environment, predominantly of political – legal or economic origin: personal insolvency regulation, business insolvency regulation, monetary and fiscal possibilities in overcoming excessive indebtedness, and banks and financial industry in generating anticipative consumption causing excessive indebtedness.]]></summary_en></project><project>
<id>1722</id><title_hr><![CDATA[Modeli i metode upravljanja inovacijama u razvoju kompleksnih inženjerskih sustava]]></title_hr><title_en><![CDATA[Models and Methods of Innovation Management in Complex Engineering Systems Development]]></title_en><user_id>4471</user_id><user_firstLast_name>Mario Štorga</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2013-11</proposal_call><code>IP-2013-11-6430</code><acronim><![CDATA[MInMED]]></acronim><duration>01.10.2014 - 30.09.2018</duration><status>Završio</status><financ_value>132.722,81 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Strojarstvo, </scie_field_hr><scie_field_en>Mechnical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet strojarstva i brodogradnje]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Mechanical Engineering and Naval Architecture]]></institution_en><team_members_id>6397, 6393, 19022, 17795, 20038, 19667, </team_members_id><team_members_names><![CDATA[Stanko Škec, Dorian Marjanović, Tomislav Martinec, Marija Majda Perišić, Vladimir Smojver, Jasmin Juranić, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[innovation dynamics, knowledge management , socio-technical systems, complex networks, engineering systems development]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[The goal of the proposed research project is to develop a set of fundamental models and methods for innovation management within and across hierarchical social networks exiting in contemporary private and public R&D organisations, and to explore and develop analyse and simulation tools for quantifying knowledge and information dynamics as a mean for prediction of the future trends in organisational innovation. The context of the socio-technological framework that transcends the organisational innovation dynamics within contemporary engineering systems and services life-cycle requires the research overriding commitment to methodological pluralism. The integrated analyse – evaluate - create – refine - validate approach will be used as research methodology.The research will build on state of the art developments in the exploration of principles of knowledge management for R&D organisations and will go further; in that it will seek to incorporate the insights from modelling, simulation and visualisation of the complex social, natural and technical systems to the knowledge and information dynamics that encompass the generation, storage, dissemination, filtering, and reprocessing of innovation across hierarchical socio-technological networks. The research effort will entail the development of concepts, theories, metrics and case studies related to the R&D organisational innovation management. The controlled experiments in real-world private and public R&D organisations will be used in research to gain valuable insights across different sectors (automotive, aerospace, energy, transportation, healthcare, public administration, etc.).It is expected that the results of the proposed research will provide valuable interdisciplinary contributions and improve overall understanding respective to the organisational innovation.]]></summary_en></project><project>
<id>1738</id><title_hr><![CDATA[Promjene u kristaliničnim materijalima izazvane ionskim snopovima MeV-skih energija]]></title_hr><title_en><![CDATA[MeV Ion Beam Induced Changes in Crystaline Materials]]></title_en><user_id>4589</user_id><user_firstLast_name>Stjepko Fazinić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2013-11</proposal_call><code>IP-2013-11-8127</code><acronim><![CDATA[MIOBICC]]></acronim><duration>15.06.2014 - 14.11.2018</duration><status>Završio</status><financ_value>107.588,26 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, </scie_field_hr><scie_field_en>Physics, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>4629, 5437, 4893, 4670, 5686, 5793, 4976, 5947, 21267, 19583, 24631, </team_members_id><team_members_names><![CDATA[Milko Jakšić, Ettore Vittone, Tonči Tadić, Zdravko Siketić, Natko Skukan, Veljko Grilj, Iva Božičević Mihalić, Donny Domagoj Cosic, Kristina Tomić, Ivana Zamboni, Marin Vukšić, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[MeV Ion Beams, Stopping Power, Ion Beam Modification of Materials, Ion Beam Analysis, Ion Beam Channeling, IBIC, RBS, PIXE, PIGE]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[In the recent years MeV ions have been extensively utilized as indispensable powerful tool in a wide range of materials science research. Ions are very efficient in creating numerous ionizations on their path through the material by ejecting/exciting electrons (electron stopping) and in creating vacancies by recoiling the whole atoms (nuclei) from their lattice sites (nuclear stopping). Therefore, irradiation of materials with energetic ion beams is considered as a) an efficient tool to alter materials physical, chemical, electrical and optical properties and b) a sensitive probe that can be used to characterise materials using some of the Ion Beam Analysis (IBA) methods. Understanding of complicated dynamical processes that lead to structural modifications of materials requires the knowledge of experimental data related to kinematics of defects during and after irradiation. Therefore the goal of the present proposal is experimental study of the time evolution of radiation induced changes induced by energetic (MeV) ion beams and their characterization using the RBI Tandem Accelerator Facility. The focus will be on studying: (i) influence of electronic stopping and related nanostructuring of materials by ion track methodology; (ii) influence of nuclear stopping to radiation damage and amorphization in crystals, including crystalline and functional materials of interest for future fusion reactors; (iii) charge transport properties in crystalline materials, focusing on novel semiconductor materials for radiation detection.  Experimental methodology relies mostly on the unique RBI dual-beam end station that will be used for ion beam irradiations and simultaneous characterization of induced changes using IBA methods like RBS and PIXE in channelling mode, ERDA, NRA and PIGE, as well as IBIC (Ion Beam Induced Charge).]]></summary_en></project><project>
<id>1741</id><title_hr><![CDATA[Razvoj suvremenog pravnog i osigurateljnog režima za hrvatske marine - unapređenje konkurentnosti, sigurnosti, sigurnosne zaštite i zaštite morskog okoliša]]></title_hr><title_en><![CDATA[Developing a Modern Legal and Insurance Regime for Croatian Marinas - Enhancing Competitiveness, Safety, Security and Marine Environmental Standards ]]></title_en><user_id>4076</user_id><user_firstLast_name>Adriana Vincenca Padovan</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2013-11</proposal_call><code>UIP-2013-11-3061</code><acronim><![CDATA[DELICROMAR]]></acronim><duration>01.03.2016 - 28.02.2019</duration><status>Završio</status><financ_value>52.442,52 eur</financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Pravo, </scie_field_hr><scie_field_en>Law, </scie_field_en><institution_hr><![CDATA[Hrvatska akademija znanosti i umjetnosti]]></institution_hr><institution_en><![CDATA[Croatian Academy of Sciences and Arts]]></institution_en><team_members_id>4077, 2814, 4464, 4201, 4194, 3984, 18987, 4386, 4187, </team_members_id><team_members_names><![CDATA[Vesna Skorupan Wolff, Nikoleta Radionov, Dorotea  Ćorić, Ranka Petrinović, Nikola Mandić, Božena Bulum, Iva Tuhtan Grgić, Marija Pijaca, Lana Ofak, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[marina, nautical tourism, transport law , marine insurance, liability, safety, security, marine environment]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[The proposed research project shall consist of an examination of the existing legal regime governing the establishment, management and the activities of the nautical tourism ports in Croatia, with a special focus on marina operator’s liabilities, insurance arrangements, standards of maritime safety and security and marine environmental protection; comparative analysis of the respective legislation, insurance arrangements and court practice in the European countries; analysis of the European marina operators’ common practices, general terms and conditions, their experiences in the combat against and dealing with the adverse events such as vessel thefts, fire, unauthorised entry, marine accidents within the port, marine pollution, etc; proposing improvements in the legal framework relating to the regime of liability and insurance of the Croatian marina operators, with a view of enhancing their competitiveness, safety, security and environmental protection standards; in particular, a recommended model of general terms and conditions would be created as an innovative business solution for marina operators and a possible reform of the respective positive legislation would be proposed, paying due respect to the necessary compliance with the relevant EU legislation. The proposed project is aimed at consolidating the relevant national legislation and clarifying the related legal concepts through the currently lacking doctrine, with a view of unifying the domestic court practice and contributing to legal certainty in the interest of all parties involved. This should lead to a progress and further sustainable development of the nautical tourism sector in Croatia subject to the requirements of the marine environmental protection, maritime safety and security, particularly considering the country’s strategic orientation to that sector of economy and the planned substantial increase of the nautical tourism ports’ berthing capacities in the following years.]]></summary_en></project><project>
<id>1742</id><title_hr><![CDATA[Sloboda volje, uzročnost i slučaj]]></title_hr><title_en><![CDATA[Free Will, Causality and Luck]]></title_en><user_id>242</user_id><user_firstLast_name>Filip Grgić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2013-11</proposal_call><code>IP-2013-11-5343</code><acronim><![CDATA[FreeWilL]]></acronim><duration>01.07.2014 - 30.06.2018</duration><status>Završio</status><financ_value>42.471,30 eur</financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Filozofija, </scie_field_hr><scie_field_en>Philosophy, </scie_field_en><institution_hr><![CDATA[Institut za filozofiju]]></institution_hr><institution_en><![CDATA[Institute for Philosophy in Zagreb]]></institution_en><team_members_id>1441, 3206, 2690, 3485, 3345, 2634, 4359, 4870, 1381, 17854, </team_members_id><team_members_names><![CDATA[Pavel Gregorić, Boris Kožnjak, Tvrtko Jolić, Ljudevit Hanžek, Dario Škarica, Ivana Skuhala Karasman, Marijan Palmovic, Tomislav Janović, Davor Pećnjak, Anna Kocsis, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[free will, causality, luck, determinism, compatibilism, moral responsibility, consciousness]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[The overall goal of our research is to contribute to our deeper understanding of what is involved in having and experiencing free will by offering some new insights and arguments in the pertaining areas. The more specific goal of our project is to produce original contributions in some central areas of research into free will, in the following disciplines: metaphysics, philosophy of mind, ethics, history of philosophy, philosophy of physics, as well in philosophical interpretations of relevant results of psychology and neuroscience. The most specific goals of the research are the following. First, we plan to show that deterministic threats to free will are surmountable. Second, we plan to show that indeterministic threats (i.e. those based on randomness and luck) are also surmountable. Third, we will argue that some problems with compatibilistic accounts are more serious than has hitherto been recognized. This is due, first, to the fact that, in our opinion, compatibilism is also susceptible to a specific luck objection, and second, to the fact that it is sometimes based on insufficiently clear notions of causality, determinism and natural laws. Fourth, we will argue that Aristotelian version of compatibilism can bring some fresh light to contemporary discussions, but that it is also susceptible to a specific luck objection.Research activities can be grouped under five main headings: 1. Causality, laws of nature and luck (1.1. Causality, laws of nature and action; 1.2. Indeterminism and luck; 1.3. The varieties of determinism), 2. Brain, mind and agency (2.1. Freedom and consciousness, 2.2. Mental causation and ascriptions of intentionality, 2.3. Some perspectives from neuroscience), 3. Moral responsibility (3.1. Principle of Alternative Possibilities, 3.2. Bioenhancement and responsibility), 4. Aristotelian perspective (4.1. Aristotle’s compatibilism, 4.2. Aristotle on moral responsibility and luck), 5. Free will, determinism and the quantum rescue.]]></summary_en></project><project>
<id>1743</id><title_hr><![CDATA[Nejednakosti i primjene]]></title_hr><title_en><![CDATA[Inequalities and Applications]]></title_en><user_id>3427</user_id><user_firstLast_name>Josip Pečarić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2013-11</proposal_call><code>IP-2013-11-5435</code><acronim><![CDATA[INEQUALITIES]]></acronim><duration>01.06.2014 - 30.05.2018</duration><status>Prekinut</status><financ_value>72.616,68 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Matematika, </scie_field_hr><scie_field_en>Mathematics, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Tekstilno-tehnološki fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Textile Technology]]></institution_en><team_members_id>1499, 3770, 4166, 3837, 3777, 4003, 3774, 630, 524, 3034, 3820, 4020, 3074, 3745, 3852, 3541, 3503, 3423, 857, 3762, 3736, 592, 3861, 3040, 3744, 4178, 3869, 3818, 795, 3484, 1149, 3389, 584, 3707, 2673, </team_members_id><team_members_names><![CDATA[Andrea Aglić Aljinović, Maja Andrić, Senka Banić, Ana Barbir, Josipa Barić, ILKO BRNETIĆ, Tomislav Burić, Vera Čuljak, Neven Elezović, Iva Franjić, Božidar Ivanković, Slavica Ivelić Bradanović, Julije Jakšetić, Rozarija Jakšić, Dragana Jankov Maširević, Milica Klaričić Bakula, Sanja Kovač, Mario Krnić, Kristina Krulić Himmelreich, Neda Lovričević, Anita Matković, Jadranka Mićić Hot, Zlatko Pavić, Ivan Perić, Jurica Peric, Tibor Poganj, Dora Pokaz, Marjan Praljak, Mihaela Ribičić Penava, Mirna Rodić Lipanović, Ksenija Smoljak, Sanja Varošanec, Ana Vukelić, Predrag Vuković, Lenka Vukšić, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[inequalities, convexity, operators, asymptotic expansions, series of special functions]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[The proposed research project belongs to the category of theoretical research in fundamental sciences, with the main purpose to stimulate gaining new knowledge. The general purpose of this project is to contribute to the systematic development of the theory of inequalities and to its integration in the current trends in mathematics, especially in the fields of real, functional and numerical analysis. Our aim is also to create and maintain a competent team of researchers whose relevant results and cooperation with other field experts from all over the world will contribute to the promotion of Croatian mathematics worldwide.Specific objectives are:-to improve, refine, interpolate, generalize Jensen’s type inequalities and related inequalities such as Jensen-Steffensen, Hermite-Hadamard, Jensen-Mercer etc.-to prove some generalizations, improvements and refinements of some classical inequalities (Holder, Minkowski, Hilbert, Hardy, Ostrowski, Gruss, Opial, Chebyshev etc.) in various settings-better understanding of different kinds of convexities (higher convexities, s-convexity and h-convexity, exponential convexity, local convexities, Schur-convexity, superquadracity etc.) with applications in inequalities;-to give further extensions and applications of the Mond-Pečarić method in operator theory, especially in obtaining reverse type operator inequalities;-to develop methods and applications of asymptotic expansions and series of special functions (asymptotic expansion and comparison of bivariate and multivariate means; research in series of Bessel and Bessel-like functions, integral expressions and summation formulae for Neumann and Kapteyn series, establishing sharp truncation error estimates occuring in sampling series approximations etc.).We expect to publish more than one hundred papers in this project period. One of our aims is to give overviews of the obtained research results. We plan to publish at least five monographs on these topics.]]></summary_en></project><project>
<id>1747</id><title_hr><![CDATA[Supramolekulska sinteza samo-organizirajućih funkcionalnih nanomaterijala i kompleksnih kemijskih sustava]]></title_hr><title_en><![CDATA[Supramolecular Synthesis of Self-Assembled Functional Nanomaterials and Complex Chemical Systems]]></title_en><user_id>348</user_id><user_firstLast_name>Leo Frkanec</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2013-11</proposal_call><code>IP-2013-11-7387</code><acronim><![CDATA[SInFONIA]]></acronim><duration>01.09.2014 - 30.09.2018</duration><status>Završio</status><financ_value>84.809,87 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, </scie_field_hr><scie_field_en>Chemistry, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>689, 4307, 963, 959, 1104, 4852, </team_members_id><team_members_names><![CDATA[JANJA MAKAREVIĆ, Milan Jokić, Tomislav Portada, Tihomir Pospišil, Ruža Frkanec, Adela Štimac, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[Supramolecular Chemistry, Self-Assembly, Gels, Hydrogels, Functional Materials, Nanomaterials, Molecular Surface Recognition, Complex Chemical Systems]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[The aim of this project proposal is supramolecular synthesis of self-assembled functional materials and study thus created complex chemical systems. Such systems exhibit a complex array of morphologies and dynamics and have a huge potential for new applications in areas ranging from materials science to medicine. The bottom–up synthesis of highly complex functional materials from simple modular blocks is an intriguing area of research. These hierarchically assembled systems extend beyond the individual molecule and rely on non-covalent interactions in a directed self-assembly process. Intrinsic properties of the materials can be modified by exploiting dynamic and specific uni-directional interactions among building blocks, thus allowing construction of novel supramolecular structures. These supramolecular networks belong to a novel category of soft biomaterials exhibiting attractive properties. Research in this project will include the formation of dynamic polymeric networks through molecular recognition and complex assembly formation. Self-assembly of small organic molecules is a suitable method for synthesis of organic nano-structured materials. LWM organo- and hydro-gels with oxalamide units represent construction units with high H-bonding potential; they are self-complementary, capable of unidirectional H-bonding suited for construction of self-assembled with fibrous morphology. In continuation of our previous research the attention will be focused on two main areas of research 1. nanofabrication; preparation of new materials by polymerization through cross linking the gel network or transcript to the TEOS and development of new organic materials that incorporate photoactive functional groups, and 2. bioinspired supramolecular systems for detection and degradation of fibrous supramolecular aggregates, such as Aß-protein and amyloid plaques (that are a major cause of Alzheimer’s disease) and vesicles functionalization for  surface molecular recognition studies. ]]></summary_en></project><project>
<id>1751</id><title_hr><![CDATA[Translacijsko istraživanje neuroplastičnosti disanja i učinka intermitentne hipoksije u anesteziji i spavanju]]></title_hr><title_en><![CDATA[Translational research on neuroplasticity of breathing and effect of intermittent hypoxia in anesthesia and sleep]]></title_en><user_id>4553</user_id><user_firstLast_name>Zoran Đogaš</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2013-11</proposal_call><code>IP-2013-11-5935</code><acronim><![CDATA[TIHO2_SLEEP_BREATH]]></acronim><duration>01.09.2014 - 31.08.2020</duration><status>Završio</status><financ_value>131.395,58 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Kliničke medicinske znanosti, </scie_field_hr><scie_field_en>Clinical sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Splitu, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Split School of Medicine]]></institution_en><team_members_id>4542, 83, 4547, 4549, 4543, 3359, 4635, 182, 65, 6675, 6725, 6329, 7034, 6899, 7175, 19211, </team_members_id><team_members_names><![CDATA[Ivana Pavlinac Dodig, Maja Rogić, Renata Pecotić, Maja Valić, Linda Lušić, Sunčana Kukolja Taradi, Mladen Carev, Tina Tičinović Kurir, Joško Božić, Mario Mihalj, Goran  Račić, Nenad Karanović, Toni Brešković, Marin Šimunić, Dušan Šuput, Tea Galić, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[intermittent hypoxia, phrenic long term facilitation, respiratory neuroplasticity, sleep apnea, neurophysiology, polysomnography]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Our understanding of the brain control of breathing and awareness of the widespread prevalence of obstructive sleep apnea syndrome (OSAS) have both increased in the last decade or two. The link between the two is poorly understood. There is growing evidence that OSAS contributes to the initiation and progression of hypertension, heart failure, cardiac ischemia, stroke and cognitive decline. Chronic sympathetic activation resulting in elevated sympathetic nerve activity and cardio-respiratory sensitivity to hypoxia appears to be important. Still, the exact mechanisms underlying the link between OSA and cardiovascular and neurophysiologic disturbances are not completely known. Intermittent hypoxia (IH) in experimental animals can mimic periods of repeated apneas seen in OSAS patients. Exposure to repeated bouts of hypoxia in human leads to increased sympathetic activity, whilst intermittent hypoxia in experimental animals evokes increases in phrenic and sympathetic nerve activities. The proposed study will examine the role of neurotransmitters/neuromodulators (e.g. serotonin and opioids) in evoking sympathetic long-term facilitation using anesthetized animal model of IH.The only way to understand complex pathophysiological interactions in OSAS patients is to use translational and multidisciplinary approach, as proposed in this project. Our focus in the human studies is to study neurophysiologic (brain motor control, control of breathing, neurographic features of peripheral nerves, and muscle sympathetic activity) function in OSAS patients and the links to metabolic, stress, and cognitive parameters. Preliminary data from pilot studies suggest it is possible to achieve the new findings using this novel approach. We will also study longitudinal therapeutic effects of the gold standard therapy in OSAS such as the overnight use of continuous positive airway pressure (CPAP) devices in Split Sleep Cohort of patients, which we plan to form during the work on this project.]]></summary_en></project><project>
<id>1755</id><title_hr><![CDATA[Uloga inozitolskih fosfata i inozitolskih pirofosfata u regulaciji staničnog ciklusa]]></title_hr><title_en><![CDATA[The role of inositol phosphates and inositol pyrophosphates in the regulation of cell cycle]]></title_en><user_id>4650</user_id><user_firstLast_name>Hrvoje Banfic</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2013-11</proposal_call><code>IP-2013-11-4597</code><acronim><![CDATA[Inopyrocycle]]></acronim><duration>01.07.2014 - 30.06.2018</duration><status>Prekinut</status><financ_value>130.731,97 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb School of Medicine]]></institution_en><team_members_id>4936, 4921, 6302, 4677, 4676, 4837, </team_members_id><team_members_names><![CDATA[Vesna Lukinović-Škudar, Vladiana Crljen, John York, Dora Višnjić, Hrvoje Lalić, Vilma Dembitz, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[inositol phosphates, inositol pyrophosphates, cell cycle, matabolism, protein pyrophosphorylation]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Inositol phosphates and pyrophosphates are second messengers generated by the sequential phosphorylation of inositol 1,4,5,-trisphosphate (InsP3). Several recent studies pointed to their role in the regulation of different cellular processes in eukaryotes, yet in many instances direct mechanistic roles remain elusive. Our recent study provided genetic, metabolic and biochemical evidence that synthesis of inositol pyrophosphates through activation of Plc1 and Kcs1 play an important role in the signalling response required for cell cycle progression after mating pheromone arrest in Saccharomyces cerevisiae (Banfic et al. J. Biol. Chem. 288: 1717-1725, 2013). However, it is still uncertain which of the pyrophosphates increased is/are responsible for Kcs1-mediated effects, and it is unclear what might be the possible link between the Kcs1-mediated increase in the level of pyrophosphates and the progression of yeast cells through the S phase of the cell cycle. This is a proposal that aims to define the mechanism of pyrophosphates-mediated regulation of cell cycle progression. We will use a set of yeasts deletion mutants to define a) the particular pyrophosphate responsible for S phase-associated effects, b) to test for the possibility that inositol pyrophosphates generated during S phase progression regulate telomere length, c) to test the possibility that the increase in the level of pyrophosphates in alpha-factor synchronized cells is associated with an increase in pyrophosphorylation of the proteins and/or protein expression or modification, and d) to determine the changes in metabolism in alpha-factor synchronized cells and to correlate them with the changes in the level of inositol pyrophosphates. Overall, this proposal seeks to elucidate lipid-derived inositol phosphate signal transduction pathways in the regulation of cell cycle and metabolism. ]]></summary_en></project><project>
<id>1762</id><title_hr><![CDATA[Prirodni zeoliti kao reaktivne barijere za obradu procjednih otpadnih voda odlagališta otpada]]></title_hr><title_en><![CDATA[Natural zeolites as a reactive barrier for landfill leachate treatment]]></title_en><user_id>639</user_id><user_firstLast_name>Marina Trgo</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2013-11</proposal_call><code>IP-2013-11-4981</code><acronim><![CDATA[NAZELLT]]></acronim><duration>20.07.2014 - 19.07.2018</duration><status>Završio</status><financ_value>89.269,36 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Kemijsko inženjerstvo, </scie_field_hr><scie_field_en>Chemical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Splitu, Kemijsko-tehnološki fakultet]]></institution_hr><institution_en><![CDATA[University of Split, Faculty of Chemistry and Technology]]></institution_en><team_members_id>4361, 3947, 917, 3380, 4454, 4501, </team_members_id><team_members_names><![CDATA[Nediljka Vukojević Medvidović, Jelena Perić, Ivona Nuić, Marin Ugrina, G. Diego Gatta, Sanja Slavica Matešić, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[natural zeolites, landfill leachate, column method, heavy metals, reactive barrier]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Limited reserves of fresh water are a serious global problem. For that reason the main objective is to preserve the quality of all available sources of drinking water. Among all the threats to water in nature, leachate landfills are most dangerous because of their complex chemical composition and continuous uncontrolled pollution of groundwater. Processes and methods of preventing the spread of pollution into groundwater and leachate treatment are a challenge for many researchers. This proposal should be a contribution to the landfill leachate treatment using natural zeolite as a reactive barrier. This material is available in nature, environmentally compatible, thermally and chemically stable, and possesses adsorption and ion exchange properties. Depending of the surface charge, zeolites can uptake organic and inorganic positive and negative species. The desired surface charge can be achieved by chemical modification using different methods at a controlled pH value. Modified zeolites should have significantly higher removal capacities and selectivity towards pollutants contained in the landfill leachate. These wastewaters are highly concentrated, have the most complex possible composition, contain low biodegradable organic matter (halogenated hydrocarbons, aromatic hydrocarbons and phenols), inorganic ions (Cl-, NH4+, SO42-,NO3-, NO2-,PO43-), and heavy metals (Cd, Cr, Cu, Ni, Pb, Zn, Mn). Many of these components have shown excellent removal from modal solutions onto zeolite; therefore investigations will start with batch studies, continue in lab-scale fixed bed columns, and finally in scale-up and multi stage columns filled with different modified zeolites. The multi stage column performance should be carried out with real leachate collected from the regulated landfills in the Dalmatian region. The exhausted zeolite, saturated with organic and inorganic pollutants, can be thermally treated and disposed of in nature, or solidified into the cement matrix.]]></summary_en></project><project>
<id>1793</id><title_hr><![CDATA[Evocirani potencijali moždanog debla i testiranje autonomnog živčanog sustava kao metode procijene progresije bolesti u bolesnika s klinički izoliranim sindromom]]></title_hr><title_en><![CDATA[Brainstem Evoked Potentials Score and Composite Autonomic Scoring Scale as a Predictors of Disease Progression in Clinically Isolated Syndrome]]></title_en><user_id>1081</user_id><user_firstLast_name>Mario Habek</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2013-11</proposal_call><code>UIP-2013-11-2622</code><acronim><![CDATA[BACIS]]></acronim><duration>01.09.2014 - 31.08.2017</duration><status>Završio</status><financ_value>98.573,23 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Kliničke medicinske znanosti, </scie_field_hr><scie_field_en>Clinical sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb School of Medicine]]></institution_en><team_members_id>5732, 4744, 4530, 3050, 5730, 4606, 5787, 4721, 4564, 4746, 5637, 5051, 17860, </team_members_id><team_members_names><![CDATA[Barbara Barun, Tereza  Gabelic, Ivan Adamec, Magdalena Krbot Skoric, Damir Petravić, Darija Mahović Lakušić, Branko Malojčić, Mila Lovrić, ivana zadro, Ivo Lušić, Silva Butković-Soldo, Marijana Lisak, Luka Crnošija, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[clinically isolated syndrome, multiple sclerosis, evoked potentials, autonomic nervous system testing, brainstem]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[About 85% of patients have onset of MS with a relapse, which is known as a clinically isolated syndrome (CIS). Several studies have shown that infratentorial lesions are related to conversion rate and long-term prognosis for patients with CIS and thus may help to identify patients at high risk for earlier occurrence of clinically relevant disability. Bearing in mind the poor correlation between clinical symptoms and MRI findings there is a need for ancillary tools in the evaluation of brainstem pathology in MS. The aim of the current study is to evaluate the role of the brainstem evoked potentials score (bilateral AEP, bilateral ocular and cervical VEMP and bilateral tongue SSEP), the modified evoked potentials score (combination of brainstem evoked potentials score and VEP and SSEP of the median and tibial nerve) and standardized autonomic nervous system testing (Composite Autonomic Severity Score (CASS)) in the prediction of conversion from CIS to MS and accumulation of future disability. After 24 months of follow-up, this study could reveal the prognostic value of the brainstem EP score, modified EP score and CASS in patients with CIS on a number of parameters including: time until second relapse, accumulation of disability, accumulation of MRI lesions in the first 6 months, time to conversion from CIS to MS according to the 2010 revision of the McDonald criteria, number of relapses in the first 2 years of follow up. It can be presumed that the brainstem EP score and CASS score as direct and indirect measures of brainstem dysfunction, respectively will prove as reliable markers of future disability of CIS and MS patients. As a consequence, this would allow us to start more appropriate treatment in a subset of patients with higher probability of worse outcome.]]></summary_en></project><project>
<id>1806</id><title_hr><![CDATA[Rimska ekonomija u Dalmaciji: proizvodnja, distribucija i potražnja u svijetlu keramičarskih radionica]]></title_hr><title_en><![CDATA[Roman Economy in Dalmatia: production, distribution and demand in the light of pottery workshops]]></title_en><user_id>3064</user_id><user_firstLast_name>Goranka Lipovac Vrkljan</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2013-11</proposal_call><code>IP-2013-11-3973</code><acronim><![CDATA[RED]]></acronim><duration>01.07.2014 - 30.06.2018</duration><status>Završio</status><financ_value>53.089,12 eur</financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Arheologija, </scie_field_hr><scie_field_en>Archeology, </scie_field_en><institution_hr><![CDATA[Institut za arheologiju]]></institution_hr><institution_en><![CDATA[Institute of Archaeology in Zagreb]]></institution_en><team_members_id>2786, 3216, 7577, 21192, 5318, 21199, 22964, </team_members_id><team_members_names><![CDATA[Ivana Ožanić Roguljić, Ana Konestra, Bartul Šiljeg, Marina Ugarković, Mato  Ilkić, Nera Šegvić, Fabian  Welc, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[Roman economy, Dalmatia, pottery, landscape archaeology, archaeometry]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Main goal of the RED project is to found out as much as possible about production, distribution and demand of goods in Roman Dalmatia through most common material found in arhaeological excavations – ceramics. From Late Hellenistic period when Central Dalmatia was enrolled in vivid Mediterranean trade, not only as a receiver of everything that comes from the larger centre, but also as a driving force of social and economic changes establishing pottery manufactures. This social transformation was enhanced by Romans. Trade of ceramic objects  is one of the main starting points for understanding the history of the Roman economy and society. For such scientific research it is necessary to establish a project using archaeometric analysis and archaeological research and a database of ceramics. Landscape archaeology methods such as field surveys, GIS, sampling patterns and statistical analysis will be used to analyse and interpret the wealth of data. RED project will include the development of an online database of documentary, archaeological material and archaeometric samples. Aim of this project will also be to establish relations between local production to the imports and to what extent was production in province Dalmatia driven by consumer demand and involvement of provincial communities within the Late Hellenistic/Republican and Imperial Roman economy.]]></summary_en></project><project>
<id>1807</id><title_hr><![CDATA[Primjena inovativnih tehnologija u proizvodnji biljnih ekstrakata kao sastojaka funkcionalne hrane]]></title_hr><title_en><![CDATA[Application of innovative technologies for production of plant extracts as ingredients for functional food]]></title_en><user_id>1243</user_id><user_firstLast_name>Verica Dragović-Uzelac</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2013-11</proposal_call><code>IP-2013-11-3035</code><acronim><![CDATA[IT-PE-FF]]></acronim><duration>01.09.2014 - 31.08.2018</duration><status>Završio</status><financ_value>128.475,68 eur</financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Prehrambena tehnologija, </scie_field_hr><scie_field_en>Food technology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prehrambeno-biotehnološki fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Food Technology and Biotechnology]]></institution_en><team_members_id>2657, 2702, 2644, 223, 2509, 2593, 2615, 2512, 2830, 1062, 1002, 1330, 1056, 2663, 2558, 3057, 3314, 5708, 17829, 24300, 25335, </team_members_id><team_members_names><![CDATA[Damir Jezek, Mladen Brnčić, Branka Levaj, IRENA LANDEKA JURČEVIĆ, Senka Djaković, Marijana Jukić, Danijela Bursać Kovačević, Jasmina Lapić, Ivana Kmetič, Sandra Pedisić, Ivona Elez Garofulić, Maja Repajić, Zoran Zorić, Sven Karlović, Marina Tranfić Bakić, Teuta Murati, Domagoj Đikić, Ivanka Žutić, Vanja Plazibat, Predrag Putnik, Domagoj Gabrić, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[medicinal and aromatic plants, innovative technologies, plant extracts, bioactive compounds, bioavailability, antioxidant properties ]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Medicinal and aromatic plants (MAPs) contain numerous bioactive compounds (BACs) (e.g. polyphenols, carotenoids, organosulphur compounds) that can affect the nutritive, chemical, microbiological, and sensory quality of food products. Additionally, they may provide numerous positive effects to the human health (such as risk reduction for: cardiovascular disease, diabetes, obesity, hypertension etc.). Due to large structural diversity among different groups of BACs and their physical/chemical properties it is important to identify/optimize the most effective extraction methods required to isolate and/or separate them from other plant components. Hence, various innovative extraction techniques (e.g. microwave-, ultrasound- and high-pressure- assisted extraction) will be tested for plant extracts production with high BACs content from selected MAPs grown in Croatia. Each applied extraction technique will be optimized with regards to particular MAP, increasing extraction yield, enhancing quality of extract, shortening extraction time, and decreasing solvent consumption. MAPs extracts and/or BACs will be analyzed for antioxidant properties with application of various assays (e.g. total antioxidant, hydrogen peroxide scavenging, and free radical scavenging, metal chelating activities). Antiproliferative effects against tumor cells and possible protective role from lipid oxidation (including antioxidant activity) will be tested in appropriate cell line model system. The MAP extracts (dried/liquid) and BACs (extracted and/or purified separately or in mixtures) will be studied in animal models for bioavailability; absorption; antioxidant activity; as ingredient for functional food products (fortified beverages and snack bars based on Mediterranean fruits), and for possible use in diabetic/hypercholesteremic management. The obtained results may provide novel opportunities for functional product categories that are likely to have positive benefits on human health.]]></summary_en></project><project>
<id>1808</id><title_hr><![CDATA[Promjenjivost Sunca i zvijezda]]></title_hr><title_en><![CDATA[Solar and Stellar Variability]]></title_en><user_id>4850</user_id><user_firstLast_name>Bojan Vršnak</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2013-11</proposal_call><code>IP-2013-11-6212</code><acronim><![CDATA[SOLSTEL]]></acronim><duration>01.09.2014 - 31.08.2018</duration><status>Završio</status><financ_value>131.715,83 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, </scie_field_hr><scie_field_en>Physics, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Geodetski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Geodesy]]></institution_en><team_members_id>6306, 6078, 6028, 4326, 5550, 5899, 6152, 6121, 6181, 19711, </team_members_id><team_members_names><![CDATA[Hrvoje Božić , Roman Brajša, Davor Sudar, Domagoj Ruždjak, Tomislav Žic, Jaša Čalogović, Mateja Dumbović, Rajka Jurdana-Šepić, Ivana Poljančić Beljan, Ivica Skokić, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[solar activity, space weather, climate, heliosphere, sun-like stars, variable stars, binary stars, accretion discs, exoplanets, substellar companions]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[The proposed four-year project connects solar physics, solar-terrestrial physics, heliospheric physics, space weather & climate, geophysics, and stellar physics. It is based on empirical/interpretative, theoretical/analytical, and theoretical/numerical approach, and concerns all astrophysical problems currently in focus of the research at the Hvar Observatory (HO) of the Faculty of Geodesy of the University of Zagreb. Thus, the proposed program is in a great deal determined by, and directed towards, effective exploitation of the observational capacities and manpower of HO. The project is divided into five thematic topics: 1) solar activity and eruptive phenomena in the solar atmosphere; 2) solar-activity impact on the Earth; 3) stellar eruptive activity; 4) radiation processes in solar and stellar atmospheres; 5) exoplanets and substellar companions. In the first topic special attention is devoted to the research of the physics of coronal mass ejections and solar flares, since they drive the most intense geomagnetic storms, as well as changes of radiation belts and ionosphere. The central issue of the second topic is the influence of the solar variability on the Earth climate. The third topic is devoted to stellar eruptive magnetic-field activity, aiming to provide a better understanding of the long-term evolutionary aspect of the solar activity. The fourth topic is an important subject not only for astrophysics, but also for plasma physics in general, since it provides an alternative view on plasma instabilities and emission processes. The fifth topic is a timely astrophysical theme, since it provides new insights into physics of planetary systems, and is very important subject for understanding of the solar-system formation and evolution.]]></summary_en></project><project>
<id>1837</id><title_hr><![CDATA[Urbanizam naslijeđa - Urbanistički i prostorni modeli za oživljavanje i unaprjeđenje kulturnoga naslijeđa]]></title_hr><title_en><![CDATA[Heritage Urbanism - Urban and Spatial Planning Models for Revival and Enhancement of Cultural Heritage]]></title_en><user_id>1458</user_id><user_firstLast_name>Mladen Obad Šćitaroci</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2013-11</proposal_call><code>IP-2013-11-2032</code><acronim><![CDATA[HERU]]></acronim><duration>01.09.2014 - 31.08.2018</duration><status>Završio</status><financ_value>110.757,18 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Arhitektura i urbanizam, </scie_field_hr><scie_field_en>Architecture and Urban Environment, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Arhitektonski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Architecture]]></institution_en><team_members_id>1459, 3550, 3010, 3625, 3024, 4796, 2560, 3157, 3056, 3015, 3190, 4392, 3174, 1319, 1194, 3469, 1196, 3084, 3098, 3917, 2936, 3480, 3407, 4778, 3208, 3027, 3220, 3213, </team_members_id><team_members_names><![CDATA[Bojana Bojanic Obad Šćitaroci, Alenka Delić, Sanja Gašparović, Jesenko Horvat, Vedran Ivanković, Tihomir Jukić, Damir Krajnik, Nenad Lipovac, Ivan Mlinar, Lea Petrović Krajnik, Biserka Dumbović Bilušić, Jasenka Kranjčević, Tamara Marić, Ana Mrđa, Tin Oberman, Boško Opalić, Marko Rukavina, Igor Gojnik, Irma Huić, Marina Pavković, Ksenija  Petrić, Dario Sironić, MARIJANA SIRONIĆ, Nikša Božić, Boris Dundović, Mirna Meštrović, Ksenija Radić, Ana Sopina, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[Cultural Heritage, Urban Planning, Spatial Planning, Heritage Enhancement, Heritage Revival]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Croatia’s urban heritage is at least 25 centuries old. Examples of cultural/architectural and landscape heritage in Croatia are numerous, valuable and diverse. Part of this heritage is recognised worldwide and is protected by UNESCO. Croatia’s most valuable heritage is protected at a national level, although a part of it has, as yet, not been recognised. For various reasons the numerous examples of Croatian heritage are in a poor condition and decaying because they don’t have a permanent use and are not included in the life of cities and towns, despite being formally protected.In former research project, Urban and Landscape Heritage of Croatia as Part of European Culture, cultural heritage was researched in an attempt to present its values and traits as part of Croatia’s national identity and culture. The new project proposal partly supplements previous project thematically and uses results of this research, but the focus of research is on the creative, sustainable and responsible usage of urban, architectural and landscape heritage, which is a non-renewable resource. Contemporary attitudes of conservationists on the holistic protection based on international conservation documents connect protection with urban and regional planning through the concept of sustainable development. The aim of proposed research is to affirm heritage as an active space and spatial resource, to include it in future life and to allow it to be the initiator and active participant in sustainable spatial, social and cultural, economic and touristic development.The research will be based on the selected case studies for each type of cultural heritage. The aim is to define spatial criteria, methods and models for revitalisation and for the implementation of new projects within cultural heritage which may contribute to their enhancement. The project results (criteria, methods, models) will be applied in spatial and urban planning and conservation practices, and will be of far-reaching impact.]]></summary_en></project><project>
<id>1839</id><title_hr><![CDATA[Procjena prihvatnog kapaciteta za turiste u zaštićenim područjima prirode]]></title_hr><title_en><![CDATA[Assessment of Carrying Capacity for Tourists in Nature Protected Areas]]></title_en><user_id>2551</user_id><user_firstLast_name>Jadranka Pečar Ilić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2013-11</proposal_call><code>IP-2013-11-2202</code><acronim><![CDATA[ACCTA]]></acronim><duration>01.07.2014 - 30.06.2017</duration><status>Završio</status><financ_value>92.729,14 eur</financ_value><scie_area_hr>Prirodne znanosti, Tehničke znanosti, Društvene znanosti, </scie_area_hr><scie_area_en>Natural sciences, Technological sciences, Social sciences, </scie_area_en><scie_field_hr>Biologija, </scie_field_hr><scie_field_en>Biology, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>2551, 5520, 5519, 5710, 4006, 3321, 5922, 17593, 13114, 4898, </team_members_id><team_members_names><![CDATA[Jadranka Pečar-Ilić, Tin Klanjšček, Sunčana Geček, Zdenko Tkalčec, Hrvoje Carić, Jasminka Klanjšček, Drago Marguš, Nina Marn, Ivana Kušan, Tarzan Legović, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[carrying capacity, nature protected area management methods, conservation, environmental modeling, calculation, GIS,  tourism, NP Krka, PP Telašćica]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Natural protected areas (NPAs) are a crucial part of nature conservation; many of them are tourist hotspots. Managers of NPAs have to balance environmental protection and tourism to maximize socio-economic benefits while avoiding irreparable environmental consequences. Since 1978, carrying capacity for tourists (CCT) has been recognized and legislated as a crucial tool in finding the balance. CCT is traditionally defined as the maximum number of people concurrently visiting an area without irreversibly damaging physical, economic, and/or socio-cultural environment. In practice, managers determine acceptable level of environmental damage, and then use adaptive management to achieve and maintain that damage level. We propose a more conservation-oriented approach of estimating CCT that maximizes nature protection. Although every tourist damages the environment, he/she also contributes to protection by providing financial assets. Without revenues from tourism, protection is significantly underfunded because meeting protection and educational goals of NPAs requires costly activities such as research, oversight, mitigation, and management. We propose to estimate CCT as the maximum number of visitors for which the marginal contribution to nature protection is positive, with the requirement that visitor satisfaction not be compromised. We will first formalize the estimation procedure, then identify tourist activities with their consequences on the environment and socio-economic parameters, develop general models for common factors affecting environmental quality of the NPAs, and integrate the models into a GIS-based framework. Finally, we will demonstrate the approach by estimating CCT for two very different protected areas crucial for Croatian tourism and the local economy: NP Krka and PP Telašćica. While the new way of estimating CCT will initiate a paradigm shift in NPA management, the two applications will contribute to Croatia&#39;s nature conservation and economy.]]></summary_en></project><project>
<id>1844</id><title_hr><![CDATA[Enzimi purinskog reciklirajućeg ciklusa iz Helicobacter pylori i Escherichie coli ]]></title_hr><title_en><![CDATA[Purine salvage pathway enzymes from Helicobacter pylori and Escherichia coli ]]></title_en><user_id>302</user_id><user_firstLast_name>Marija  Luić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2013-11</proposal_call><code>IP-2013-11-7423</code><acronim><![CDATA[PSPE]]></acronim><duration>01.09.2014 - 30.11.2018</duration><status>Završio</status><financ_value>121.883,02 eur</financ_value><scie_area_hr>Prirodne znanosti, Biomedicina i zdravstvo, </scie_area_hr><scie_area_en>Natural sciences, Biomedicine and health sciences, </scie_area_en><scie_field_hr>Biologija, </scie_field_hr><scie_field_en>Biology, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>690, 424, 3310, 3300, 3781, 3687, 2999, 23182, 4270, 23168, </team_members_id><team_members_names><![CDATA[Ivana Leščić Ašler, Zoran Štefanić, Saša Kazazić, Biserka Kojić-Prodić, Biserka Žinić, Vanda Plečko,  Agnieszka  Bzowska, Ante Bubić, Branimir Bertoša, Petar Knezevic, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[Purine metabolism, enzyme inhibiton, drug design, H. pylori, E. coli, crystal structure, analytical biochemistry, H/D exchange, susceptibility testing]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[The main goal of the proposed project is to identify new drug targets and accordingly design, prepare and characterise new drugs for Helicobacter pylori eradication. Helicobacter pylori is a bacterium that colonizes one half of the world population and it is regarded as one of the most invasive human pathogens responsible for development of many diseases. There are two possible pathways that organisms can use to synthesize purines as indispensable building blocks for DNA and RNA synthesis. However, bacterium H. pylori  uses the salvage pathway, only. Therefore, we plan to disable H. pylori growth and replication by inhibiting the key enzymes, purine nucleoside phosphorylase and adenylosuccinate synthetase, on this pathway.The proposed project includes the interdisciplinary team with expertise in the research areas of molecular biology and genetics, biochemistry and biophysics, macromolecular crystallography, biological mass spectrometry, molecular modelling, organic synthesis, analytical ultracentrifugation methods, susceptibility testing, and managing ‘big data’ through data integration (extracted from various databases). All equipment necessary to accomplish the proposed research is available in the host institution (Rudjer Bošković Institute) except for analytical ultracentrifuge available by foreign co-worker A. Bzowska (Warsaw, Poland).]]></summary_en></project><project>
<id>1845</id><title_hr><![CDATA[INTEGRATIVNI PRISTUP PROUČAVANJU TRANFORMACIJSKE ULOGE TURIZMA U 21. STOLJEĆU]]></title_hr><title_en><![CDATA[AN INTEGRATED APPROACH FOR THE STUDY OF TRANSFORMATIVE ROLE OF TOURISM IN 21ST CENTURY]]></title_en><user_id>5000</user_id><user_firstLast_name>RENATA TOMLJENOVIĆ</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2013-11</proposal_call><code>IP-2013-11-6164</code><acronim><![CDATA[TRANS-TOURISM ]]></acronim><duration>01.09.2014 - 31.03.2019</duration><status>Završio</status><financ_value>77.259,63 eur</financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Ekonomija, </scie_field_hr><scie_field_en>Economy, </scie_field_en><institution_hr><![CDATA[Institut za turizam]]></institution_hr><institution_en><![CDATA[Institute for Tourism in Zagreb]]></institution_en><team_members_id>5782, 7029, 1004, 3669, 5707, 5245, 5228, 5218, 7502, </team_members_id><team_members_names><![CDATA[Sanda Čorak, Daniela Angelina Jelinčić, Snježana  Boranić Živoder, ZRINKA MARUŠIĆ, Neda Telišman-Košuta, NEVEN IVANDIĆ, Nikola Ćelić, Ivan Sever, IRENA ATELJEVIC, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[culture, tourism, transformation, values, behaviour, change]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[The overall objective of TRANS-TOURISM is to critically investigate the role of tourism in attaining the vision for sustainable world of peace and harmony, and to develop tools and options in order to provide practical models to harness the transformative power of tourism. The main proposition is that tourism, as an enormous economic and social force, can be a significant contributor to the vision for sustainable world. The vision for personal is an urgency today and already the new group of culture creatives is identified spearheading this movement. This vision is also embedded in the overall vision of Europe 2020 for creation of more just and inclusive societies and provision of greater quality of lives for all citizens. This proposition will be analysed from three aspects: by capturing the transformative power of past and present travel experience of the culture creatives, motivations and practises of pioneering change-makers who create transformational travel products and tourism stakeholders’ receptiveness to integrate transformational view of tourism into design of their products. The research will employ mixed-method approach, involving quantitative (surveys) and qualitative (in-depth interviews, focus groups, workshops, diary) methods. The research on the theme is in infancy and the project builds the existing research in three ways. In contrast to the existing studies, the research will focus on those whose values are transformed and will seek to capture the role of travel experience in that process, on the long term behavioural change following the travel in contrast to the existing focus on immediate post-trip attitude change. The research will also overcome the existing host – industry – guest divide, as it will include entrepreneurial perspective of transformative travel providers, mainstream industry players and host communities in the process of fostering activities which can facilitate societal transformation through tourism.  ]]></summary_en></project><project>
<id>1846</id><title_hr><![CDATA[Neuralna osnova viših spoznajnih funkcija]]></title_hr><title_en><![CDATA[Microcircuitry of higher cognitive functions]]></title_en><user_id>2567</user_id><user_firstLast_name>Zdravko Petanjek</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2013-11</proposal_call><code>IP-2013-11-5943</code><acronim><![CDATA[COGNITIVECIRCUIT]]></acronim><duration>01.07.2014 - 30.11.2018</duration><status>Završio</status><financ_value>132.722,81 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb School of Medicine]]></institution_en><team_members_id>3907, 4699, 5085, 3483, 4770, 2549, 2646, 2632, 5063, 4972, 18991, 12673, </team_members_id><team_members_names><![CDATA[Dubravko Jalšovec, Davor Mayer, Mislav Stjepan Žebec, Sanja Darmopil, Marija Baković, Ana Hladnik, Domagoj Džaja, Ivana Bičanić, Ivana Miler, Fadi Almahariq, Branka Hrvoj Mihic, Dora Mandić, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[pyramidal neurons, interneurons, glutamate, GABA, synaptic transmission, cortical connectivity, evolution, cognition, schizophrenia, autism, layer III]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Most of our knowledge about organization of cortical circuitry comes from studies in rodents, but those results have not lead to major breakthrough for the treatment of human brain disorders. Despite common principles in connectivity, human cerebral cortex contains specific neuron types like associative layer III pyramidal neurons and subtypes of calretinin expressing GABA-interneurons. They are key elements of human microcircuitry which molecular specificity and neuronal interaction between and inside columns needs to be determined in order to assess how human cerebral cortex processes information. The aim of this project is to study organization and molecular properties of microcircuitry in the human frontal cortex that is believed to have unique features being the biological substrate for the most complex cognitive functions. The emphasis is to use histo-molecular techniques to dissect connectivity at cellular level and to establish a experimental monkey model to study microcircuitry in collaboration with Brain Dynamic Institute Marseille (http://ins.medecine.univmed.fr/) and Max Planck Institute for Evolutionary Anthropology Leipzig (http://www.eva.mpg.de/). This will enable formation of unique database providing structural, physiological, molecular and genetic fingerprint of identified neurons as well as their connectivity within the entire cortical network in primates. Such database will be extremely valuable to create a simulation model of the human brain and to understand neuronal network alterations in various brain disorders. Studying cortical circuitry in the human is in the focus of current neuroscience research. Proposed project has potential to overcome gap in knowledge at cellular level, providing information gainful for more comprehensive interpretation of data obtained by imaging studies. Through the project Croatian researchers will be trained in experimental techniques that will be implemented into Croatian research and medical institutions.]]></summary_en></project><project>
<id>1848</id><title_hr><![CDATA[Kulturna povijest kapitalizma: Britanija, Amerika, Hrvatska]]></title_hr><title_en><![CDATA[A Cultural History of Capitalism: Britain, America, Croatia]]></title_en><user_id>4485</user_id><user_firstLast_name>Tatjana  Jukić Gregurić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2013-11</proposal_call><code>IP-2013-11-1543</code><acronim><![CDATA[CHCBAC]]></acronim><duration>01.07.2014 - 30.06.2018</duration><status>Završio</status><financ_value>78.901,06 eur</financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Filologija, </scie_field_hr><scie_field_en>Philology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Filozofski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Humanities and Social Sciences]]></institution_en><team_members_id>3808, 4823, 5020, 4315, 4929, 5089, 5189, 5401, 5527, 5906, 6602, 23126, </team_members_id><team_members_names><![CDATA[Jelena  Šesnić, Borislav Knežević, Martina Domines Veliki, Sven Cvek, Stipe  Grgas Mufa, Tihana Klepač, Vladimir Brljak, Iva Polak, Vanja Polić Jurković, Grant Farred, Kimberly Engber, Hrvoje Tutek, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[cultural history, economy, capitalism, Britain, America, Croatia]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Our claim is that a detailed analysis of what constitutes a cultural history of capitalism is indispensable for a grasp of recent Croatian cultural and political history, and of the current positioning of Croatia in Europe and the world. We start from the observation that the scholarly discourses in Croatia have so far not sufficiently acknowledged the cultural complexity of the economic sphere, especially the seminal significance of histories of Britain and America in that regard. Our methodological point of departure is therefore the assertion that the economic sphere can be understood only in reference to the entirety of culture. We intend to explore the complexity of this totality as refracted through cultural histories of Britain and America, as a horizon necessary for understanding Croatian cultural history. Our intent is to investigate complex interrelations of the sophisticated Victorian variant of capitalism and its American mutations, in the 19th and the 20th centuries. This applies primarily to Cold-War America, when capitalism contrasted to socialism becomes a totalizing formula to regulate various economic and political structures, but also the sphere of culture where public vs private is defined. Thus caught in relation to socialism, capitalism is definitive to life in the former Yugoslavia as well; this then sediments into a difficult genealogy which burdens capitalism when, after the fall of the Berlin Wall, it enters formerly socialist countries, now as a platform for understanding and regulating postsocialism. Our approach is anchored in the assumption that research based only in economy or political theory fails to shed light on the logic of capitalism. This defines our methodology: we maintain that a truly functional analysis of the impact of capitalism demands a confluence of literary history, film studies, psychoanalysis, philosophy, cultural theory and, especially, the knowledge specific to English and American Studies. ]]></summary_en></project><project>
<id>1850</id><title_hr><![CDATA[Transporna, magnetska i termodinamička svojstva odabranih anorganskih i organskih materijala]]></title_hr><title_en><![CDATA[Transport, magnetic and thermodynamic properties of selected inorganic and organic materials]]></title_en><user_id>5009</user_id><user_firstLast_name>Ivan Kokanović</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2013-11</proposal_call><code>IP-2013-11-6216</code><acronim><![CDATA[TRANMAGTHERPROMAT]]></acronim><duration>01.09.2014 - 31.08.2018</duration><status>Završio</status><financ_value>98.841,88 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, </scie_field_hr><scie_field_en>Physics, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>1173, 5781, 5722, 3227, 6713, 17743, </team_members_id><team_members_names><![CDATA[Mario Novak, Boran Leontić, Sanda Pleslić, Mirko Baćani, Cooper John Robert, Filip Orbanić, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[Superconductivity, topological insulators,  metallic glasses,  nanocrystalline alloys, conducting polymers, ]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[This Project is centred on the physics of selected YBCO single crystals, HTSC, topological insulators, TI, metallic glasses, MG, nanocrystalline alloys, NCA, and conducting polymers, CP, and investigation of their transport, thermodynamic, thermoelectric, magnetic, superconducting and structural properties. The primary issue addressed in the field of HTSC is the existence of electron pockets in low magnetic fields   caused by charge density waves, CDW, in pure YBa2Cu3O6+x single crystals. We propose to measure the magnetisation and specific heat in the whole doping range  to extract the total density of states at the Fermi level and thereby determine the number of pockets.  At the same time we will look for thermodynamic signatures of the CDW phase transitions.  Other unresolved controversies which will be investigated include the doping evolution of the mean-field upper critical field and whether Gaussian superconducting fluctuations can account for the magnetisation and specific heat of both underdoped and overdoped YBa2Cu3O6+x single crystals at T>Tc. In the field of TI, we will investigate the thermoelectric properties of bismuth based chalcogenide (BiSbTeSe2) and 3D Dirac semimetals and to find the evidence of the linear dispersion and nontrivial topology of these materials. Our next aim is to achieve ferromagnetism in selected TIs; TlBi(S0.5Se0.5)2, PbSnTe and PbSnSe by doping with Mn or Fe and gain understanding of the mechanism responsible for the ferromagnetic ordering.   In the field of MG and NCA   the goal is to gain some insight into the glassy structure and mechanism involved in its crystallisation. In the field of organic conductors we intend to investigate PANI-DBSA (DBSA-dodecylbenzenesulfonic acid) thin film samples. A particular emphasis of the research will be the further development of novel apparatus to measure the magnetisation and specific heat of small single crystals which are often of the highest quality.  ]]></summary_en></project><project>
<id>1853</id><title_hr><![CDATA[Transport i kemodinamika elemenata u tragovima u slatkovodnim i priobalnim sedimentacijskim sustavima]]></title_hr><title_en><![CDATA[Transport and Chemodynamics of Trace Elements in Freshwater and Coastal Sedimentary Systems]]></title_en><user_id>60</user_id><user_firstLast_name>Goran Kniewald</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2013-11</proposal_call><code>IP-2013-11-7555</code><acronim><![CDATA[TRACESS]]></acronim><duration>01.09.2014 - 31.08.2017</duration><status>Završio</status><financ_value>93.793,66 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Geologija, </scie_field_hr><scie_field_en>Geology, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>989, 624, 4900, 2726, 3584, 544, 399, 614, 5147, 5151, </team_members_id><team_members_names><![CDATA[Nevenka Mikac, Neda Vdović, Goran Mihelčić, Željka Fiket, Martina Furdek, Julijan Dobrinić, Tadej Dolenec, Irena Jurina Tokić, Niko Bačić, Mavro Lučić, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[trace elements, chemodynamics, sediments, freshwater systems, coastal systems]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[The aim of the proposed project entitled &#39;&#39;Transport and Chemodynamics of Trace Elements in Freshwater and Coastal Sedimentary Systems&#39;&#39;  (TRACESS) is to increase our understanding of the biogeochemical cycles that are important forfreshwater and coastal sedimentary systems in karstic areas, using specific groups of elements i.e. anthropogenic and bioactive (Cd, Co, Cr, Cu, Mn, Ni, V, Zn), rare earth elements (REE), toxic elements and compounds (organotin compounds) which were chosen to represent different biogeochemical environments where a suite of geochemical processes can be traced. ]]></summary_en></project><project>
<id>1855</id><title_hr><![CDATA[Organska zagađivala u okolišu - markeri i biomarkeri toksičnosti]]></title_hr><title_en><![CDATA[Organic Pollutants in Environment - Markers and Biomarkers of Toxicity]]></title_en><user_id>5026</user_id><user_firstLast_name>Davor Želježić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2013-11</proposal_call><code>IP-2013-11-8366</code><acronim><![CDATA[OPENTOX]]></acronim><duration>01.09.2014 - 31.08.2018</duration><status>Završio</status><financ_value>132.044,86 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Javno zdravstvo i zdravstvena zaštita, </scie_field_hr><scie_field_en>Public health and health services, </scie_field_en><institution_hr><![CDATA[Institut za medicinska istraživanja i medicinu rada]]></institution_hr><institution_en><![CDATA[Institute for Medical Research and Occupational Health]]></institution_en><team_members_id>4035, 4034, 2516, 3033, 221, 555, 549, 1390, 3076, 5303, 331, 2513, 1490, 323, 1224, 1212, 1384, 1376, 198, 4161, 4156, 2633, 341, 1223, 12850, 2649, </team_members_id><team_members_names><![CDATA[Vilena Kašuba, Ružica Rozgaj, Nevenka Kopjar, Suzana Žunec, Vedran Micek, Ivančica Trošić, Ivan  Pavičić, Ana Marija Marjanović, Ana Lucić Vrdoljak, Radovan Fuchs, Vlasta Drevenkar, Sanja Fingler Nuskern, Marija Dvoršćak, Želimira Vasilić, Gordana Mendaš Starčević, Sanja Stipičević, Snježana Herceg Romanić, Darija Klinčić, Zorana Kljaković-Gašpić, Irena Brčić Karačonji, Nataša Brajenović, Tanja Živković, Alica Pizent, Mirta Milic, Anja Mikolić, Blanka Tariba Lovaković, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[pesticides, organochlorine pollutants, genotoxicity, endocrine disruption, oxidative stress, cytoskeleton, environmental distribution, risk assessment]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[The proposed project is based on Directive 2009/128/EC, the EU Thematic Strategy for Pesticides, and the Collegium Ramazzini Statement concerning control over pesticides and their impact on human health and the environment. The project will focus on studying two major pesticide classes with three subgroups per each: (A) insecticides (organophosphates, neonicotinoids, and pyrethroids), (B) herbicides (triazines, organophosphates, allelopathic), and persistent organochlorine pollutants under the Stockholm convention. Low concentrations corresponding to real-life exposures will be evaluated based on residential exposure levels, occupational exposure limits, acceptable daily intakes, and reference doses in appropriate cell lines and animal models. The malsegregation of chromosomes (X, Y, 9), integrity of gatekeeping genes (TP53, c-Myc), and protein structures (cytoskeleton components) will be studied within the transplacental genotoxic evaluation of selected pesticide groups. Among these, some are suspected to be endocrine disruptors. Potential effects on sex hormone levels will be assessed in neonatal rats and transfer via mother’s milk in pubertal rats. Oxidative stress will be estimated by measuring lipid peroxidation and activity of antioxidative enzymes in vitro and in vivo. We will study the processes affecting the distribution of pesticides in water/soil systems as well as the genotoxicity of their residues in soil and water. Results for low levels of pollutant exposure will serve to significantly extend the knowledge on their genotoxicity, cytotoxicity, sex endocrine disruption, mechanisms of oxidative stress, and distribution in the environment. Also, they will be used as a base for amending and adopting the Croatian National Action Plan for sustainable use of pesticides in accordance with demands postulated in Directive 2009/128/EC and the EU Thematic Strategy for Pesticides.]]></summary_en></project><project>
<id>1857</id><title_hr><![CDATA[Dijagnostika autizma s robotskim evaluatorom]]></title_hr><title_en><![CDATA[Autism Diagnostic Observation with Robot Evaluator]]></title_en><user_id>5054</user_id><user_firstLast_name>Zdenko Kovačić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2013-11</proposal_call><code>IP-2013-11-1024</code><acronim><![CDATA[ADORE]]></acronim><duration>01.09.2014 - 31.01.2019</duration><status>Završio</status><financ_value>132.722,81 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Elektrotehnika, </scie_field_hr><scie_field_en>Electrical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id>5295, 5272, 5058, 3759, 5090, 5244, </team_members_id><team_members_names><![CDATA[Jasmina Stošić, Damjan Miklic, Frano Petric, Sanja  Šimleša, Maja Cepanec, Stjepan Bogdan, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[social robotics, humanoid robots, autism, small children, diagnostics, rehabilitation]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Autism spectrum disorder (ASD) is a developmental disorder characterized by impairment in social interaction, verbal and nonverbal communication and by repetitive behaviors and interests. The diagnosis, which is usually given during the preschool period, depends on the education and experience of human evaluators, which can be susceptible to personal bias. The ongoing collaboration between the researchers from the Faculty of Electrical Engineering and Computing (FER) and Faculty of Education and Rehabilitation Sciences (ERF) initiated the use of humanoid robots in the process of ASD diagnostic procedures in preschool children. The goal of the project is the development of a robot-based diagnostic protocol and testing of its verification in clinical settings. The robots will be used as ASD co-evaluators to help a human evaluator to assess the child behavior objectively. To the best of our knowledge, such a robot-based ASD diagnostics system will be the first of its kind. Technically, this means developing specific robot skills and behaviors to be deployed within the standard clinical diagnostic procedure of ASD. The robots will have two functions: observation and quantitative measurement of child’s social responses; and performance of standardized social presses designed to provoke child response. This involves actions such as analyses of the audio signal and differentiation of vocalizations and speech, detection of eye-gaze direction, performance of different actions and gestures and utilization of human-robot and robot-robot interaction to attract child attention. Our interdisciplinary approach includes ERF&#39;s development of diagnostic protocol and its testing on children with and without ASD and FER&#39;s realization of needed robot behaviors using methods and algorithms from social signal processing, computer vision, machine learning and cognitive reasoning. This involves work on cooperation, cognition and human-robot interaction, focusing on multimodal communication.]]></summary_en></project><project>
<id>1858</id><title_hr><![CDATA[Višenamjensko očitavanje DNA / RNA sekundarne strukture molekularnim kemijskim senzorima]]></title_hr><title_en><![CDATA[Multifunctional molecular sensing of DNA/RNA secondary structure by chemical sensors]]></title_en><user_id>480</user_id><user_firstLast_name>Ivo Piantanida</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2013-11</proposal_call><code>IP-2013-11-1477</code><acronim><![CDATA[DNA/RNA-MolSense]]></acronim><duration>01.09.2014 - 31.10.2018</duration><status>Završio</status><financ_value>131.119,86 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, </scie_field_hr><scie_field_en>Chemistry, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>1214, 2953, 1232, 3781, 3684, 1476, 444, 2648, 5802, 17784, </team_members_id><team_members_names><![CDATA[Marijana Radić Stojković, Lidija-Marija Tumir, Ivo Crnolatac, Biserka Žinić, Dijana Saftić, Željka Ban, Vilko Smrečki, Aleksandar Višnjevac, Carsten Schmuck, Prof. Dr., Tamara Šmidlehner, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[Molecular sensing, DNA/RNA, fluorescence, oligopeptide, nucleobase]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Molecular recognition of DNA/RNA is of fundamental importance e.g. for gene transcription and regulation, protein synthesis or cell-division. Small molecules selectively targeting specific DNAs or RNAs are therefore highly interesting not only to understand such processes in more detail but also for potential medicinal applications, as sensors or probes for fluorescence based bioimaging as well as for analytical purposes in isolated biosamples. Proposal is based on the collaboration between I. Piantanida and Prof. Dr. C. Schmuck (Germany), joined results in leading chemistry journals (Chemistry, Eur. J; 2010 and 2012, J. Am. Chem. Soc. 2012; Org. Biomol. Chem. 2011, Bioorg. Med. Chem. Lett. 2008). We want to design, synthesize and study highly selective probes for the sensing of DNA/RNA with emphasis on the multi-purpose probes: single molecules able to simultaneously differentiate by several highly sensitive spectrometric methods between the most common secondary structures of ds- DNA/RNA. For increased affinity and selectivity, we plan to test new, more efficient fluorophores (cyanine, phenanthridine, fluorescent nucleobases-Piantanida group) combined with pyrrole-guanidinium cations (Schmuck group) and explore structural diversity of the compounds, by combinatorial approach (solid phase synthesis) based on peptide backbone carrying recognition units/fluorophores. The interaction with DNA/RNA will be studied by Piantanida group (UV/Vis, fluorescence, CD/LD spectroscopy, DSC/ITC microcalorimetry), screening of oligopeptide libraries by IRORI method and atomic force microscopy by Schmuck group. Proposal addresses CSF goals: a) support the collaboration with well-established international leaders, b) foster training of young researchers by work on the INTERNATIONAL research; c) expected results with commercializing potential (novel biochemical probes and/or drugs). The latter feature (c) will be studied within FP7-REGPOT “Innomol” Project at Ruđer Bošković Institute.]]></summary_en></project><project>
<id>1862</id><title_hr><![CDATA[Između Dunava i Mediterana. Uloga rimske vojske u mobilnosti ljudi i roba na tlu Hrvatske u antici. ]]></title_hr><title_en><![CDATA[Between the Danube and the Mediterranean. Exploring the role of Roman military in the mobility of people and goods in Croatia during the Roman Era]]></title_en><user_id>4028</user_id><user_firstLast_name>Mirjana Sanader</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2013-11</proposal_call><code>IP-2013-11-6505</code><acronim><![CDATA[RoMiCRO]]></acronim><duration>15.06.2014 - 14.06.2018</duration><status>Završio</status><financ_value>78.832,04 eur</financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Arheologija, </scie_field_hr><scie_field_en>Archeology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Filozofski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Humanities and Social Sciences]]></institution_en><team_members_id>7522, 7512, 7519, 7513, 7516, 7534, 7526, 7532, 7537, 7545, 7547, 7536, 7551, 7548, 17731, </team_members_id><team_members_names><![CDATA[Marina Milićević Bradač, Domagoj Tončinić, Ina Miloglav, Iva Kaić, Vinka Matijević, Domagoj Perkić, Igor Vukmanić, Sanja Ivčević, Ana Pavlović, Saša Denegri, Tatjana Lolić, Zrinka Buljević, Zrinka Šimić-Kanaet, Tomislav Šeparović, Mirna Vukov, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[Roman Empire, Danube, Mediterranean, mobility, economy, Roman military, local elite.]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[The objective of the project is to investigate and extend scientific information to aid in solving as yet unanswered questions about the significance of the Roman military in changes that occurred on the territory of Republic of Croatia in the period from the first contacts with Rome (229 BC) to the end of the Marcomannic Wars (180 AD). The geopolitical strategy of Rome in conquered regions was to encourage the integration process, where the Roman army gave its contribution. Archaeological data testify that the indigenous communities of Illyricum reacted differently to this process. Some were willing to accept the Roman heritage (e.g. Liburnians), while the others (e.g. Delmatae) were providing resistance. Given previous research today we have a number of valuable studies about certain aspects of Roman domination. However, they are primarily focused either on the ancient written sources or the archaeological material from Dalmatia and Pannonia. This research of the integration would cover for the first time the Roman military presence on the area of Croatia. The main focus is on the Roman military sites along the Dalmataean and the the Danube limes. New data will be derived using the methodology purposely created for this project and includes archaeological survey, classification, comparison and evaluation of all available data both archaeological and ancient sources with the application of the variable of geographic origin. Such research has never been undertaken in Croatia. The results would fill the informational gaps that exist for this part of the Empire through the analysis of the largest possible amount of information about the Roman army activities and the integration of indigenous people. The project leader’s research has focused so far on the problems of Roman provincial archaeology. Many years of her successful research of and of all the collaborators guarantee the sustainability of the approach and the successful implementation of the project objectives.]]></summary_en></project><project>
<id>1865</id><title_hr><![CDATA[Hrvatska filozofija i znanost u europskom kontekstu od 12.-20. stoljeća]]></title_hr><title_en><![CDATA[Croatian philosophy and science in the European context between the 12th and 20th century]]></title_en><user_id>1321</user_id><user_firstLast_name>Pavo Barišić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2013-11</proposal_call><code>IP-2013-11-3524</code><acronim><![CDATA[HRFIZ]]></acronim><duration>01.06.2014 - 31.05.2018</duration><status>Završio</status><financ_value>53.752,74 eur</financ_value><scie_area_hr>Humanističke znanosti, Prirodne znanosti, </scie_area_hr><scie_area_en>Humanities, Natural sciences, </scie_area_en><scie_field_hr>Filozofija, </scie_field_hr><scie_field_en>Philosophy, </scie_field_en><institution_hr><![CDATA[Institut za filozofiju]]></institution_hr><institution_en><![CDATA[Institute for Philosophy in Zagreb]]></institution_en><team_members_id>1321, 1442, 748, 307, 505, 808, 811, </team_members_id><team_members_names><![CDATA[Pavo Barišić, Bruno Ćurko, Mihaela Girardi-Karšulin, Željka Metesi Deronjić, Snježana Paušek-Baždar, Nenad Trinajstić, Vanja Flegar, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[Croatian philosophy, history of philosophy, history of science, natural sciences,aesthetics, Neo-Platonism, Aristotelianism, alchemy, postmodern]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[We hereby submit to the HRZZ the project “Croatian philosophy and science in the European context between the 12th and 20th century” for financial support. Due to the integrative nature of the modern world, the primary issue for each member of the European and global community is the preservation of its identity, which implies cherishing national culture and the inherent philosophical and scientific tradition. Croatia’s accession to the EU has imposed an even stronger need for preservation. Research into Croatian philosophy and science started at the turn of the 20th century, but to re-examine national identity each generation inevitably has to revert to tradition, which is why studies of the works of Croatian philosophers and scientists should be our permanent mission. Continuing the work of previous researchers, our desire is to analyse the still unexplored aspects of Croatian philosophy and science in order to gain better insight into their contribution to European philosophy and science. That is why this project plans to tackle the following topics: “Reception of Plato’s philosophy in the works of Croatian philosophers between the 12th and 16th century”; “The development and shifts in Aristotelianism during the 16th and 17th century”; “The philosophy of Juraj Dragišić”; “Croatian aesthetics and poetics in the European context between the 16th and 18th century”; “The relationship between natural philosophy and alchemy in the works of Croatian authors Andrija Dudić, Pavle Skalić, and Frane Petrić”; “The alchemy in Croatia from 14th to 18th”century; “The history of Croatian chemistry during the development of natural sciences in the 19th and 20th century”; “A review of the history of Croatian philosophy in the 19th and 20th century”. The aim of this project is an anthology that would present the results of four years of research and serve as the basis for creating a comprehensive overview of the entire history of Croatian philosophy and science.]]></summary_en></project><project>
<id>1875</id><title_hr><![CDATA[Kromatografsko pročišćavanje biomolekula i njihova karakterizacija]]></title_hr><title_en><![CDATA[Chromatographic purification of biomolecules and their characterization]]></title_en><user_id>111</user_id><user_firstLast_name>Marija Brgles</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2013-11</proposal_call><code>UIP-2013-11-8193</code><acronim><![CDATA[CHROBIO]]></acronim><duration>15.09.2014 - 14.09.2017</duration><status>Završio</status><financ_value>89.765,81 eur</financ_value><scie_area_hr>Prirodne znanosti, Biomedicina i zdravstvo, Biotehničke znanosti, </scie_area_hr><scie_area_en>Natural sciences, Biomedicine and health sciences, Biotechnical sciences, </scie_area_en><scie_field_hr>Kemija, </scie_field_hr><scie_field_en>Chemistry, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu]]></institution_hr><institution_en><![CDATA[University of Zagreb]]></institution_en><team_members_id>3085, 1144, 3357, 102, 936, 17755, </team_members_id><team_members_names><![CDATA[Jelena Ivančić Jelečki, Tihana Kurtović, Maja Markušić, Beata Halassy, DUBRAVKO FORČIĆ, Dora Sviben, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[chromatography, viruses, plasma proteins, snake venom, monoliths, bioanalytics, aggregation]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Aim of the proposed research is the design of non-invasive chromatographic methods suitable for purification and concentration of biomolecules (viruses and proteins) and their characterization. Purification and analysis methods will be focused on measles virus, snake venom and antivenom proteins, and human plasma proteins. Measles virus is used as a vaccine and is found very suitable as a gene vector and as an oncolytic virotherapeutic, with the last two applications requiring large amounts of the virus. Venom is an antigen for antivenom production and both require careful analysis in order to obtain the final product of high quality. Proteins from plasma, namely albumin and immunoglobulin, are of great medical importance and their purification and stability are of utmost significance. All these biomolecules are important as biotechnological products and are subjected to rigorous quality requirements to ensure their safe usage. Therefore, non-invasive purification methods upgrading their quality and sustainable production and ensuring stability of these fragile biomolecules are essential. This project will base purification on chromatography using monolith stationary phases which are featured by their suitability for biomolecules due to high porosity, high binding capacity and convective based transport. Ion-exchange and affinity chromatography will be employed and various conditions tested for obtaining target material with high purity and yield. Also, various formulation conditions enabling preservation of virus viability and protein functionality and stability throughout the process will be tested. The analysis of the virus infectivity and protein functionality, removal of contaminants and the overall procedure effectiveness will be done by classical biochemical and virological methods as well as by some novel methods such as nanoparticle analysis that enables detection of virus and protein aggregates (NanoSight).]]></summary_en></project><project>
<id>1879</id><title_hr><![CDATA[Povezanost fleksibilnosti, aktivnosti i strukture u porodici dipeptidil-peptidaza III]]></title_hr><title_en><![CDATA[Flexibility, activity and structure correlations in the dipeptidyl peptidase III family]]></title_en><user_id>2974</user_id><user_firstLast_name>Sanja Tomić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2013-11</proposal_call><code>IP-2013-11-7235</code><acronim><![CDATA[FlAcS]]></acronim><duration>01.07.2014 - 31.10.2017</duration><status>Završio</status><financ_value>86.741,12 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, </scie_field_hr><scie_field_en>Chemistry, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>5071, 2975, 56, 3310, 2700, 2638, 1522, 1429, 4619, 17832, </team_members_id><team_members_names><![CDATA[Marija Abramić, Antonija Tomić, Borislav Kovačević, Saša Kazazić, Dejan Agić, Igor Sabljić, Zrinka Karačić, Nina Jajčanin Jozić, Mihaela Matovina, Marko Tomin, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[dipeptidyl peptidase III, metallopeptidase, catalytic activity, protein flexibility, MD simulations, QM/MM, H/D exchange, protein interactions]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Within the project frame we intend to investigate diversity in evolutionary conserved metallopeptidase family M49 (DPP III family) through characterization of catalytic, structural and dynamical properties of its members. The project would encompass five dipeptidyl peptidases III (DPP III): human, yeast, two bacterial orthologs, from thermophile Caldithrix abyssi and oral pathogen Porphyromonas gingivalis, and a DPP III from plant Physcomitrella patens. The DPP III cleaves dipeptides from the N-terminus of many oligopeptides and contributes to the intracellular protein metabolism as well as to endogenous defense against oxidative stress. Human DPP III (h.DPP III) is also related to pathological processes of cataractogenesis, tumor growth and influenza virus infection. The project research should elucidate whether the large flexibility determined for h.DPP III is conserved within DPP IIIs, and how it correlates with the protein function. It would reveal submolecular details important for substrate stabilization and, in the case of h.DPP III, the enzymatic mechanism. Elucidation of the key interactions between h.DPP III and Keap1 protein (Nrf2-Keap1 signalling pathway is major regulator of cytoprotective responses to oxidative and electrophilic stress), and possible correlation of DPP III flexibility with the complex stability, should aid in clarification of its cellular roles. Plant DPP III, differently from DPP IIIs in other organisms possesses a NUDIX box. The project should elucidate its potential dual activity (peptidase and NUDIX). Study of DPP III from thermophile should improve our knowledge on thermophile proteins, potentially useful in biotechnology. In order to fulfill the outlined goals a finely tuned multidisciplinary approach would be used in which molecular biology, biochemistry and mass spectrometry methods would be complemented with bioinformatics, multiscale molecular modeling (coarse grained/all atom MD, QM/MM) and macromolecular crystallography.]]></summary_en></project><project>
<id>1880</id><title_hr><![CDATA[Proteomski pristup otkrivanju biomarkera ranog oštećenja bubrega i srca u pasa]]></title_hr><title_en><![CDATA[Proteomic approach in the discovery of early-stage biomarkers in kidney and cardiac disease of dog]]></title_en><user_id>801</user_id><user_firstLast_name>Vladimir Mrljak</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2013-11</proposal_call><code>IP-2013-11-4135</code><acronim><![CDATA[BioDog]]></acronim><duration>01.07.2014 - 30.06.2018</duration><status>Završio</status><financ_value>132.722,81 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Veterinarska medicina, </scie_field_hr><scie_field_en>Veterinary medicine, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Veterinarski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Veterinary Medicine]]></institution_en><team_members_id>3369, 6678, 4117, 6240, 4115, 6598, 6734, 2720, 6965, 6338, 5882, 2601, 6943, 6501, 17792, 19055, 2779, 19049, 19047, </team_members_id><team_members_names><![CDATA[Vesna Matijatko, Martina Crnogaj, Mirna Brkljačić, Jelena Selanec, Marin Torti, Živičnjak Tatjana, Josipa Kuleš, Blanka  Beer Ljubić, Renata Barić Rafaj, Jose Ceron, Alan Kovacevic, Srđan Vučinić, Carlos de Torre, Mazzucchelli Gabriel, Petra Nižić, Mangesh Bhide, Anita  Horvatić, Asier Galan, Guillemin Nicolas, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[biomarkers, dog, proteomics, kidney, heart, babesiosis, idiopathic dilated cardiomyopathy, chronic valvular disease]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Proteins play essential roles in every cellular process. Biomarkers have the potential to identify key disease indicators at the individualised level, as well as to detect a disease at the early-stages before the development/advance of a serious illness. The emergence of innovative, post-genomic technology, like proteomics, led to the development of strategies aimed at identifying altered, sensitive biomarkers specific to the disease among thousands of molecules present in biological samples. Blood and urine contains multitude, unstudied, and unknown biomarkers, particularly in low-molecular region of blood and urine proteome. Babesiosis, idiopathic dilated cardiomyopathy (iDCM), and chronic valvular disease (CVD-MV) in dogs are common and serious disease. The aims of the project is: to discover novel, early-stage biomarkers of kidney and cardiac disease in dogs which could lead toward more precise and adequate diagnose, prognosis, and monitoring of these diseases; to perform a proteomic analysis on the sera and urine of dogs with uncomplicated and complicated form of babesiosis, as well as dogs with diagnosed iDCM and CVD-MV in order to identify novel, early-stage diagnostic and prognostic biomarkers; to expand the pathway signalling research in order to improve the understanding of pathogenesis for studied disease; to validate new biomarkers for studied diseases.  Tthese expected scientific outcomes will contribute in practice: (a) in a short term view, to detect individualised molecular fingerprints; to improve the diagnosis and prognosis of iDCM, CVD-MV, and babesiosis, as well as potential targets for novel approaches to monitor the therapies of these diseases; to enable the ability to personalise the treatment of individual patients resulting in enhanced patient care; and (b) in a long-term view, to allow entry of proteomics in clinical veterinary medicine in Croatia and transfer of knowledge in –omics- technologies in other parts of veterinary medicine.]]></summary_en></project><project>
<id>1884</id><title_hr><![CDATA[Jadranske geopolitike u modernosti, 1493.-1914.]]></title_hr><title_en><![CDATA[The Modern Geopolitics of the Adriatic Sea, 1493-1914]]></title_en><user_id>5171</user_id><user_firstLast_name>Josip Vrandečić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2013-11</proposal_call><code>IP-2013-11-8469</code><acronim><![CDATA[Megas]]></acronim><duration>01.07.2014 - 30.06.2018</duration><status>Završio</status><financ_value>17.373,42 eur</financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Povijest, </scie_field_hr><scie_field_en>History, </scie_field_en><institution_hr><![CDATA[Sveučilište u Splitu, Filozofski fakultet]]></institution_hr><institution_en><![CDATA[University of Split, Faculty of Humanities and Social Sciences]]></institution_en><team_members_id>5524, 6986, 2763, 5570, </team_members_id><team_members_names><![CDATA[Nikša Varezić, Edi Miloš, Marko Trogrlić, Marko Rimac, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[Imperio Maris Adriatici, Heartland, Venice, Austria, Ottoman Empire, Napoleon, Irredentism]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[The project aims to draw attention to the foreign politics and the military build-up of the great and middle powers at the Adriatic during the both early modern period and the 19th century. The starting point of the study is the Ottoman occupation of Bosnia in 1463 confirmed by defeat of Croatian army in the Battle of Krbava in 1493. The main allies of anti-Ottoman resistance Habsburgs, Venice and the popes sought to prevent the Ottoman penetration to the Adriatic and in the West. In their long term efforts they used tools of military revolution that has prevailed on their side. However, the early modern alliance is marked by a profound Habsburg-Venetian rivalry on the Adriatic which was ended by the fall of Venice in 1797 year. A new contender at the Adriatic, the revolutionary France, sought to repel Russians and Britons, and to provide a springboard to the East. After the fall of Napoleon, Austria secured supremacy on the sea, but the newly proclaimed Kingdom of Italy continued the centuries-long conflict over the Adriatic. In addressing the historical prospective, the project focuses on publishing five books which will present each phase of the competition and the main protagonists in this conflict.     1. Josip Vrandečić, The Adriatic Mission Zadar of Minuccio Minucci, the Archbishop of Zadar, 1596-1604. 2. Nikša Varezić, Republic of Dubrovnik and the Holy See, 1645-1699. 3. Marko Rimac, The Cetina region between Ottoman and Venetian rule (1683-1730). 4. Marko Trogrlić-Josip Vrandečić, Reports of Dalmatian Governor Vincenzo Dandolo to Emperor Napoleon, 1806-1809. 5. Marko Trogrlić, Memoirs of the Dalmatian Governor General Gabriel Rodić, 1812-1890. ]]></summary_en></project><project>
<id>1895</id><title_hr><![CDATA[Raznolikost i interakcije kestena, patogene gljive koja izaziva rak kestena i virusa koji inficira gljivu: učinak na oporavak kestena]]></title_hr><title_en><![CDATA[Diversity and interactions of chestnut, chestnut blight fungus and biocontrol agent – virus: implications on chestnut recovery]]></title_en><user_id>761</user_id><user_firstLast_name>Mirna  Ćurković Perica</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2013-11</proposal_call><code>IP-2013-11-5381</code><acronim><![CDATA[Chestnut]]></acronim><duration>30.06.2014 - 29.06.2017</duration><status>Završio</status><financ_value>98.944,85 eur</financ_value><scie_area_hr>Biotehničke znanosti, Prirodne znanosti, </scie_area_hr><scie_area_en>Biotechnical sciences, Natural sciences, </scie_area_en><scie_field_hr>Šumarstvo, </scie_field_hr><scie_field_en>Forestry, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>975, 4710, 1532, 1336, 2565, 757, 2506, 1456, 17770, 19883, </team_members_id><team_members_names><![CDATA[Marilena Idžojtić, Mirta Tkalec, Ljiljana Krstin, Daniel Rigling, Rosemary Vuković, Igor Poljak, Marin Ježić, Zorana Katanić, Lucija Nuskern, Jelena Mlinarec Novosel, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[biological control, chestnut disease, epigenetics, hypovirulence, molecular ecology]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[European sweet chestnut is an important multipurpose tree species. For decades, chestnut blight, a disease caused by one of the world´s most aggressive invasive pathogens Cryphonectria parasitica has been causing high mortality in chestnut forest populations and orchards. However, the fungus can be controlled by the naturally-occurring virus Cryphonectria hypovirus 1 (CHV1) which causes a reduction in fungal virulence and sporulation (a phenomenon called hypovirulence), which in turn enables infected trees to recover. Hypovirulence is the most efficient way to successfully control chestnut blight in Europe, but unfortunately the spread of CHV-1 is limited by the fungal diversity and its sexual reproduction. This project aims at revealing individual and joint aspects of the dynamic three-lateral interaction between chestnut, its fungal pathogen and the pathogen-biocontrol agent-virus. The proposed study will: (1) reveal the diversity of natural chestnut populations in south-eastern Europe, (2) connect the sequences and 3-D structures of CHV1 subtype I proteins with the level of fungal hypovirulence, (3) reveal the role of epigenetic changes of fungal genome in respect to hypovirus infection and geographical spread of the fungus (4) assess the efficiency of naturally-occurring virus isolates to induce chestnut recovery in natural conditions. The results will also contribute to the combat efforts against chestnut blight in the field conditions, by enabling production of therapeutic paste for induction of recovery in a valuable chestnut cultivar.]]></summary_en></project><project>
<id>1901</id><title_hr><![CDATA[Očuvanje genofonda šumskog drveća u svjetlu klimatskih promjena]]></title_hr><title_en><![CDATA[Conservation of genetic resources of forest trees in light of climate changes]]></title_en><user_id>5275</user_id><user_firstLast_name>Mladen Ivanković</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2013-11</proposal_call><code>IP-2013-11-8131</code><acronim><![CDATA[ConForClim]]></acronim><duration>01.09.2014 - 31.08.2018</duration><status>Završio</status><financ_value>111.487,16 eur</financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Šumarstvo, </scie_field_hr><scie_field_en>Forestry, </scie_field_en><institution_hr><![CDATA[Hrvatski šumarski institut]]></institution_hr><institution_en><![CDATA[Croatian Forest Research Institute]]></institution_en><team_members_id>5744, 5235, 5716, 5607, 17850, 12638, 44, 20996, 21001, 13263, </team_members_id><team_members_names><![CDATA[Sanja Novak Agbaba, Nevenka Ćelepirović, Marija Gradečki-Poštenjak, Maja Popović, Sanja Mrmić, Ivica Čehulić, Saša Bogdan, Netzer Florian, Anđelina Gavranović, Aikaterini Dounavi, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[Genetic conservation, Climate changes, Forest , provenance trials, variability, Quercus robur, Fagus sylvatica ]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[The preserving of the genetic diversity of the forest types is the basis for sustainable management and conservation of the natural composition of the forests. Natural forests make up 95% of the total forests in Croatia and in its wealth geographic region contains different ecological types and a large number of the forest tree species. Global climate changes, rising temperatures, falling rainfall, occurrence of the extreme weather events directly affect on genetic diversity. The main objective of the proposed project is to make recommendations for the conservation of the genetic diversity of the forest trees. Precondition for achieving the goal is the identification and understanding of the genetic variability of the individual tree species. The research to be carried out by the project would be based on the common oak and beech. On existing genetic tests that were established at different sites, data on the survival and growth of plants, phenology, silvicultural properties, plant resistance to pests, etc should be collect. The stem forest stands from which the seed was taken will be used for collecting the data of health condition, fruiting and climatic parameters. The genetic diversity of the provenance will be analyzed by DNA markers. This project should be continued and expanded research on the identification of proven European beech resistant to drought, which are conducted in the framework of a bilateral cooperation with Germany (MSES-DAAD 2013/14) and the preservation of the gene pool and study of the variability of our most important tree species which are conducted as part of the project “Breeding and forest seed” supported by MSES of Croatia. From the economic point of view, the project aims is to raise the category of the forest reproductive material (FRM) in a higher category according to the Law of FRM (Official Gazette 75/2009, 61 /2011 - EU directive EC/105/99). Higher category guarantees a higher quality, and thus a higher price in the market.]]></summary_en></project><project>
<id>1911</id><title_hr><![CDATA[Rekombinacija, popravak DNA i očuvanje integriteta genoma: novi putevi]]></title_hr><title_en><![CDATA[DNA recombination, repair and maintenance of genome integrity: new pathways]]></title_en><user_id>5202</user_id><user_firstLast_name>Davor Zahradka</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2013-11</proposal_call><code>IP-2013-11-2978</code><acronim><![CDATA[RECNEWPATH]]></acronim><duration>01.09.2014 - 31.12.2018</duration><status>Završio</status><financ_value>131.125,64 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Biologija, </scie_field_hr><scie_field_en>Biology, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>5240, 5308, 5923, 5816, 5340, 5343, 5910, </team_members_id><team_members_names><![CDATA[Ksenija Zahradka, Damir Đermić, Dušica Vujaklija, Miroslav Radman, Jelena Repar, Svjetlana  Cvjetan, Tina  Paradžik, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[hommologous recombination, DNA repair, genome stability, Escherichia coli, Deinococcus radiodurans, RecA protein, gross chromosomal rearrangements]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Homologous recombination is an essential biological process that is involved in DNA repair and in the maintenance of genome integrity. The RecA protein is a key component of recombinational systems in bacteria. Its homologs are also present in higher organisms including humans. RecA functions in the form of nucleoprotein filaments that are assembled on single-stranded DNA, and which catalyze pairing and strand exchange between two homologous DNA duplexes. In Escherichia coli, the RecBCD and RecFOR protein complexes mediate RecA filament assembly, and consequently, play an important role in recombination. We have recently discovered that some E. coli mutants recombine quite efficiently in the absence of both RecBCD and RecFOR complexes. This recombination is RecA-dependent suggesting the existence of an alternative RecA loading activity. The aim of the project is to genetically characterize this RecBCD- RecFOR-independent (RecBFI) recombination pathway, and gain insight into this novel mechanism of RecA filament assembly. Although RecA is crucial for efficient recombination in bacteria, the recA mutants of radiation-resistant bacterium Deinococcus radiodurans display a significant residual ability to repair double-strand DNA breaks. Recent results from our group have shown that this RecA-independent repair is quite inaccurate leading to gross chromosome rearrangements. Our project is to identify the key genes/proteins involved in this RecA-independent repair, and to characterize, at the sequence level, gross genome rearrangements in D. radiodurans. Given that recombination is a fundamental process largely conserved during evolution, our research on bacteria may reveal molecular mechanisms that are applicable to eukaryotic recombination systems. Thus, the results of our project could be instructive for research on cancer and other human hereditary diseases related to defects in DNA recombination functions. ]]></summary_en></project><project>
<id>1912</id><title_hr><![CDATA[Detekcija objekata više razreda za pametna vozila i sigurnije ceste]]></title_hr><title_en><![CDATA[Multi-class object detection for smart vehicles and safer roads]]></title_en><user_id>361</user_id><user_firstLast_name>Siniša Šegvić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2013-11</proposal_call><code>IP-2013-11-1395</code><acronim><![CDATA[MULTICLOD]]></acronim><duration>01.10.2014 - 30.09.2017</duration><status>Završio</status><financ_value>93.538,64 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Računarstvo, </scie_field_hr><scie_field_en>Computer sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id>6558, 6564, 6565, 6914, 6351, 6700, 6984, 7053, 7393, </team_members_id><team_members_names><![CDATA[Josip Krapac, Zoran Kalafatić, Ivan Krešo, Axel Pinz, Marko Ševrović, Valentina Zadrija, Domagoj Jakobović, Ivan Sikirić, Albert  Diosi, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[Computer vision, structure from motion, object detection, image categorization, multi-body structure from motion]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Throughout the last decades we witness persistent improvement in understanding ways to make machines see. Consequently, opportunities for computer vision applications are becoming more and more abundant. Understanding dynamic traffic scenes is especially interesting due to exciting applications in the fields of smart vehicles (driver assistance, autonomous cars) and intelligent transportation systems (road safety inspection, adaptive traffic control). Nevertheless, many of these applications are out of reach since the computers are still unable to match human perception. We believe that this gap would be reduced by improving our understanding of scalable detection of multiple object classes in dynamic scenes.The task of object detection is to localize objects of interest in input images. We address detection in the most general case where the objects of interest exhibit large appearance variation. In this case the problem is often referred to as multi-class object detection. Our proposal focuses on dynamic traffic scenes acquired by a calibrated stereo rig from the driver&#39;s perspective. We propose to develop detection approaches which would combine estimated camera motion and scene structure with learned appearance features, and to experimentally compare them with the state of the art. We shall employ advanced methodologies such as SfM, dense stereo, variational optimization, scene flow, spatio-temporal descriptors, latent SVM and Fisher vectors. These methodologies shall enable us to achieve improvements upon the state of the art in terms of scalability and detection performance. This will open way to exciting applications capable of reducing traffic accidents, improving efficiency and decreasing traffic congestion. Some of these applications shall be demonstrated by experiments on a real autonomous car. The proposed research would also contribute to a future unified theory of computer vision which would encompass detection, reconstruction and categorization.]]></summary_en></project><project>
<id>1915</id><title_hr><![CDATA[Biološki učinci vina: utjecaj vinifikacijske tehnologije, dealkoholizacije i starenja vina]]></title_hr><title_en><![CDATA[Biological effects of wine: the influence of vinification technology, dealcoholization and aging of wine]]></title_en><user_id>2679</user_id><user_firstLast_name>Mladen Boban</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2013-11</proposal_call><code>IP-2013-11-8652</code><acronim><![CDATA[BioWine]]></acronim><duration>01.09.2014 - 31.08.2019</duration><status>Završio</status><financ_value>132.466,75 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo, Biotehničke znanosti, </scie_area_hr><scie_area_en>Biomedicine and health sciences, Biotechnical sciences, </scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Splitu, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Split School of Medicine]]></institution_en><team_members_id>3385, 4348, 3112, 5297, 3823, 3690, 2542, 809, 3346, 3068, 3048, 21325, 12573, 24315, </team_members_id><team_members_names><![CDATA[Ivica Grković, Natalija Filipović, Jungbauer Alois, Višnja Katalinić, Danijela Skroza, Vlado Krauthaker, Ivana Mudnić, Nikolina Režić Mužinić, Ana Šešelja Perišin, Nataša Boban, Josip Volarević, Ana Marija Milat, Benjamin Benzon, Danica Ivanković, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[wine, wine technology, cardiovascular, antimicrobial, anti-inflammatory, antioxidant]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Grape production technology and procedures in wine making and processing significantly affect biochemical composition and organoleptic properties of wine. However, the effects of different enological procedures on biological activity of wine are poorly investigated.The overall aim of this project, which represents an interdisciplinary research effort of experts from fields of biotechnology and biomedicine, is to investigate how different enological procedures in wine making (changes of maceration time, partial/complete dealcoholization, aging of wine) may affect its biological activity. This also includes investigation of potential differences in distinctive biological effects between wines obtained by the technology of white and red wine production.In contrast to the process of red wine production, in the white wine production there is no maceration in contact with grape seeds and skins, and only fermentation of immediately separated grape juice occurs. So, biological potentials of white wines may considerably differ from that of red wines. Conversely, if even short maceration is allowed in the process of white wine making, polyphenolic content and antioxidant potential of such wines is significantly enhanced. There are several studies demonstrating superior effects of red versus white wine on certain cardiovascular parameters. However, epidemiological evidence demonstrating specific benefits of red over white wine is poor and conclusive studies comparing the two are missing.Detailed biochemical analyses of all test wines will be performed and their biochemical properties will be correlated with their biological activity.Among numerous biological effects of wine and its constituents, this project focuses on cardiovascular, antioxidative, anti-inflammatory and antibacterial effects of wine that will be examined on a spectrum of in vitro and in vivo biological systems including small laboratory animals and human volunteers.]]></summary_en></project><project>
<id>1924</id><title_hr><![CDATA[Numeričko modeliranje složenih elektromagnetskih pojava u transformatorima]]></title_hr><title_en><![CDATA[Numerical Modelling of Complex Electromagnetic Phenomena in Transformers]]></title_en><user_id>312</user_id><user_firstLast_name>Željko Štih</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2013-11</proposal_call><code>IP-2013-11-1118</code><acronim><![CDATA[NM_TRAF]]></acronim><duration>01.08.2014 - 31.07.2018</duration><status>Završio</status><financ_value>122.273,20 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Elektrotehnika, </scie_field_hr><scie_field_en>Electrical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id>314, 2877, 328, 319, 1117, 1373, 324, 2797, 2823, 2777, 2712, 2792, 4947, 4355, </team_members_id><team_members_names><![CDATA[Sead Berberović, Livio Šušnjić, Martin Dadić, Bojan Trkulja, Žarko Janić, Dalibor Filipović-Grčić, Tomislav Župan, Robert Sitar, Mladen Marković, Kosjenka Capuder, Franjo Kelemen, Igor Žiger, Goran Plišić, Ivan Šulc, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[numerical methods, transformers, insulation systems, lossess, high frequency modelling]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Transformers are crucial devices in efficient and reliable transmission and distribution of electricity. Croatian transformer manufacturers are among a top few in the world, and their annual production is worth about €300 million, what is about 2% of the world production. It is possible to keep this position on the world market only if there is a close collaboration between the academic community and transformer manufacturers. Notable progress in technology of transformers is based on utilization of new materials and application of advanced design methodologies, which incorporate sophisticated numerical methods for modelling of processes in transformers. This project is focused on research and development of advanced numerical techniques for solving various electromagnetic phenomena in transformers and their application in design. Crucial subjects in transformer design are: insulation system, electromagnetic losses and windings. Consequently, researches within this project are organized in three subprojects:1.	New methods for design of insulating systems. The aim of this subproject is to develop new comprehensive numerical method for computation of electric fields within the insulating system.2.	Computation of electromagnetic losses with the aim to develop a new method of estimation of stray losses level of power transformer, as well as the methodology of simultaneous modelling of electromagnetic field, thermal field and fluid dynamics field in transformers.3.	High frequency modelling of windings. The objective of this subproject is to develop fast and accurate procedures for the determination of capacitances, inductances and resistances in high-frequency range. These elements will be used for creating an equivalent lumped-element circuit for determination of voltage stresses along a winding.The overall goal is to reduce dimensions of transformers and to increase their reliability by application of new methods and procedures. ]]></summary_en></project><project>
<id>1942</id><title_hr><![CDATA[Matematičko modeliranje, analiza i računanje s primjenama na kompleksne mehaničke sustave]]></title_hr><title_en><![CDATA[Mathematical modelling, analysis and computing with applications to complex mechanical systems]]></title_en><user_id>2945</user_id><user_firstLast_name>Zlatko Drmač</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2013-11</proposal_call><code>IP-2013-11-9345</code><acronim><![CDATA[MMACACMS]]></acronim><duration>01.09.2014 - 31.08.2018</duration><status>Završio</status><financ_value>77.606,72 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Matematika, </scie_field_hr><scie_field_en>Mathematics, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>4557, 5056, 4816, 5431, 4757, 17823, </team_members_id><team_members_names><![CDATA[Luka Grubišić, Zvonimir Bujanović, Josip Tambača, Ivica Nakić, Nela Bosner, Ivana Šain, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[scientific computing, complex mechanical systems, eigenvalue problems, model reduction, distributed control, high perfomance scientif computing]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[This proposal is focused on functional and numerical analysis of mathematical models of selected complex mechanical systems from mathematical physics and engineering, with particular emphasis on the development of numerical methods and robust algorithms for computing. Such operator theoretic models are particularly amenable to be treated algebraically in the context of efficient and robust computational procedures of modern numerical linear algebra. The themes include adaptive (interior penalty) discontinuous Galerkin method in the penalty based formulation of the model for the complex mechanical system (e.g. stent), and vibration analysis for powertrains (car industry).  In a related topic of vibration control, we study distributed control using dynamic multipliers from the dissipativity theory.  In the frequency domain, we consider the problems of system identification and model order reduction posed as problems of rational approximation in the Hardy space H2. For all considered problems, we devise numerical algorithms and identify core numerical linear algebra computational tasks for which we plan to develop robust algorithms. These include Arnoldi-type eigensolver for both linear and quadratic large scale eigenvalue problems, and high accuracy algorithms for structured matrices of paired Cauchy structure. All developed algorithms will be delivered also as high performance mathematical software.]]></summary_en></project><project>
<id>1945</id><title_hr><![CDATA[Epigenetička regulacija glikozilacije immunoglobulina G]]></title_hr><title_en><![CDATA[Epigenetic regulation of IgG glycosylation]]></title_en><user_id>5416</user_id><user_firstLast_name>Vlatka Zoldoš</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2013-11</proposal_call><code>IP-2013-11-3361</code><acronim><![CDATA[EpiGlycoIgG]]></acronim><duration>01.10.2014 - 30.09.2018</duration><status>Završio</status><financ_value>132.034,67 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Biologija, </scie_field_hr><scie_field_en>Biology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>5420, 5620, 5359, 5449, 5468, 5425, 5596, 5428, 5952, 17847, 1497, </team_members_id><team_members_names><![CDATA[Gordan Lauc, Aleksandar Vojta, Ivana Samarzija, Paula Dobrinić, Marija Klasić, Dora Markulin, Vedrana Vičić Bočkor, Genadij Razdorov, Toma Keser, Vanja Tadić, Petra Korać, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[DNA methylation, Epigenetics, Histone modifications, IgG, Protein glycosylation, TALENS]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[IgG is one of the main effectors of the immune system. Contrary to antigen binding properties which are defined by nucleotide sequence for its Fab part, effector functions of IgG are mostly regulated by Fc glycosylation, which is regulated by complex interplay of dozens of genes in the IgG glycosylation pathway and different environmental factors. Different clones of B lymphocytes have defined patterns of glycosylation, indicating temporal stability in the glycosylation pathway. DNA CpG methylation is the most stable epigenetic modification and is thus the most prominent candidate for “fixation” of the IgG glycosylation profile in different clones. Our past and current genome wide association studies (GWAS) are identifying complex genetic network which regulates IgG glycosylation. In this project we will use several complementary experimental approaches to identify genes and epigenetic regulatory mechanisms which regulate IgG glycosylation. IgG glycosylation is relevant in numerous diseases, including autoimmune diseases, inflammatory diseases and cancer. Several epigenetic drugs are already used to treat cancer, and many others are developing. Understanding of the role of the epigenetic regulation in IgG glycosylation will provide new targets for the development of new epigenetic drugs and new biomarkers for patient stratification. ]]></summary_en></project><project>
<id>1950</id><title_hr><![CDATA[Pogrebni običaji i društvo kasnog brončanog doba na jugu Karpatske kotline]]></title_hr><title_en><![CDATA[Late Bronze Age mortuary practices and society in southern Carpathian Basin]]></title_en><user_id>3646</user_id><user_firstLast_name>Daria Ložnjak Dizdar</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2013-11</proposal_call><code>UIP-2013-11-5327</code><acronim><![CDATA[BAMPICa]]></acronim><duration>01.07.2014 - 30.06.2017</duration><status>Završio</status><financ_value>77.908,29 eur</financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Arheologija, </scie_field_hr><scie_field_en>Archeology, </scie_field_en><institution_hr><![CDATA[Institut za arheologiju]]></institution_hr><institution_en><![CDATA[Institute of Archaeology in Zagreb]]></institution_en><team_members_id>5790, 7071, 7061, 1371, 7110, 7022, 7601, </team_members_id><team_members_names><![CDATA[Petra Rajić Šikanjić, Marko Dizdar, Stašo  Forenbaher, Zrinka Premužić, Boris Kavur, Carola Metzner-Nebelsick, Marie Louise Stig Sorensen, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[Late Bronze Age, mortuary practices, society,  archaeology, anthropology, southern Carpathian Basin]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[This project proposes to combine archaeology and physical anthropology in order to expand the current knowledge of Late Bronze Age (LBA) mortuary practices and society in Carpathian Basin. It will integrate analyses of burial features and associated artifacts with analyses of cremated human remains from at least seven urnfield cemeteries in northern Croatia, dated between 13th and 9th century BC. We shall seek correlations between skeletal and artifactual evidence, which should allow us to recognize regularities and possible discrepancies linked to a specific gender or age group. Our primary aim is to investigate the variability of mortuary practices as reflected in modes of corpse treatment and disposal. At a more general level, we shall combine our data in order to investigate LBA social identities in southern Carpathian Basin. Our second aim is to investigate whether the traditionally perceived difference between &#39;Urnfield culture&#39; and &#39;Belegiš II group&#39; can be detected in mortuary evidence other than urns. Our sample of 120 burials covers a time span of six centuries, which will allow us to monitor the diversity of mortuary practices during the entire LBA and also contribute to the resolution of regional chronology. In order to archive the data, as well as to distribute and promote our findings, we shall design a public-access data base, organize a round table with experts from region and publish our results in a monograph.]]></summary_en></project><project>
<id>1955</id><title_hr><![CDATA[Formacija i destrukcija domena u vodenim otopinama]]></title_hr><title_en><![CDATA[Multi-scale description of meso-scale domain formation and destruction]]></title_en><user_id>5374</user_id><user_firstLast_name>Larisa Zoranić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2013-11</proposal_call><code>UIP-2013-11-4514</code><acronim><![CDATA[MS-FORMDES]]></acronim><duration>15.09.2014 - 14.12.2017</duration><status>Završio</status><financ_value>75.375,93 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, </scie_field_hr><scie_field_en>Physics, </scie_field_en><institution_hr><![CDATA[Sveučilište u Splitu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Split, Faculty of Science]]></institution_en><team_members_id>5591, 5569, 6896, 1469, 3589, 6868, 19038, 19062, </team_members_id><team_members_names><![CDATA[Bernarda Lovrinčević, Martina Požar, Marijana  Mijaković, Franjo Sokolić, Nada Ilić, Aurelien Perera, Yogesh Sonavane, Tomislav Primorac, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[associated liquids, micro-heterogeneity, molecular dynamics, integral equation theory, antimicrobial peptides]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[The physics of associated liquids, amphiphilic solutions and lipids in water is determined by competing hydrophobic and hydrophilic interactions between various molecular groups. By exploring assemblies ranging from molecular to cellular sizes we are aiming at  building a unified view of the principal mechanisms responsible for domain formation and destruction. This new approach hasn&#39;t been explored as such in similar research projects. In the project&#39;s first year, by molecular dynamic simulations, we will quantify micro-heterogeneity in liquids as a structural order that exists on the local scale and doesn&#39;t propagate on the global scale. As a continuation of the first-year results, we will study how the structure of the above mentioned liquids changes when dissolving molecules that promote or destroy domains defined by the local ordering. The used methods will be simulations and integral equation theory. In parallel with the molecular scale studies, the cellular membranes will be probed by means of experimental measurements and simulations. The aim will be to describe the mechanism of destruction of lipid bilayers induced by antimicrobial peptides. Principal investigator Larisa Zoranić has competencies to establish a new research group with an interdisciplinary subject and members of diverse fields because of her scientific background in physics, biology and biophysics. She has experience working in both international and Croatian groups, thus obtaining the required managing skills. The group&#39;s acquired knowledge and expertize will ensure a good quality start towards more demanding issues that stem from the project. The aims and methods of this research are competitive internationally in the area of molecular physics and biophysics. This kind of innovative project, built around an interdisciplinary group and having strong connections with the diploma and doctorate studies, will strengthen the Croatian scientific network.]]></summary_en></project><project>
<id>1982</id><title_hr><![CDATA[Napredni tekstilni materijali dobiveni ciljanom modifikacijom površine]]></title_hr><title_en><![CDATA[Advanced textile materials by targeted surface modifications]]></title_en><user_id>747</user_id><user_firstLast_name>Sandra Bischof</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2013-11</proposal_call><code>IP-2013-11-9967</code><acronim><![CDATA[ADVANCETEX]]></acronim><duration>01.09.2014 - 31.01.2019</duration><status>Završio</status><financ_value>131.289,40 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Tekstilna tehnologija, </scie_field_hr><scie_field_en>Textile technology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Tekstilno-tehnološki fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Textile Technology]]></institution_en><team_members_id>3887, 3088, 1464, 4810, 5211, 5841, 1504, 1494, 1466, 1481, 7190, 17700, 15905, 17701, 17882, 17882, </team_members_id><team_members_names><![CDATA[Edita Vujasinović, Anita Tarbuk, Ružica Brunšek (Šurina), Tihana Dekanić, Sandra Flinčec Grgac, Tanja Pušić, Marijana Pavunc, Zorana Kovačević, Ana Budimir, Branka Vojnović, Branka Marinovic, Iva Matijević, Eva Magovac, Ana Sutlović, Suzana Kutnjak-Mravlinčić, Suzana Kutnjak-Mravlinčić, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[advanced materials, textiles, surface modification, fibre reinforced composites, nano-metal particles, LCA, ]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[The demand for advanced textile materials has dramatically increased during the last few decades, in particular for engineering, medical and technical applications. A new sight proposed by this project is in the merging of so far separate research teams involved in the development of advanced textile materials, through targeted eco-driven surface modifications. Surface pre-treatments and modification will be carried out on selected sustainable textile materials, using environmentally friendly substances and processes, in order to attain antimicrobial, flame retardant, oil/hydrophobic, wellness or medical properties obtaining high added value textiles. Different environmentally friendly methods of microwave, ultrasound or plasma modification processes will be used to enhance targeted functionalities as well as to increase interfacial adhesion between fibres and polymer matrix in fibre reinforced composites. The other approach of the production of highly active surfaces which will have capability to block UV and microwave radiation, enhance oil and water repellence, antimicrobial, self-cleaning, and flame retardant properties is in the application of micro/nano-particles such as TiO2, ZnO, Cu, Ag and Au. These particles can be applied on the surface of fibers, textiles, clothing or inlayers for footwear. Detailed characterization of each treatment effectiveness, so as their effect on humans and the environment will be investigated. Laundering durability and maintenance properties are equally important as the effectiveness of developed advanced material. Introduction of novel eco-driven surface modification processes in textile production will be complemented by the risk analysis and sustainability issues, focusing onto production and product safety, usage and recyclability of newly developed product without significant environmental burden. Innovative textile products will be directed towards the needs of the textile, chemical, pharmaceutical or medical industries. ]]></summary_en></project><project>
<id>1984</id><title_hr><![CDATA[Diracovi operatori i teorija reprezentacija]]></title_hr><title_en><![CDATA[Dirac operators and representation theory]]></title_en><user_id>5573</user_id><user_firstLast_name>Pavle Pandzic</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2013-11</proposal_call><code>IP-2013-11-4176</code><acronim><![CDATA[representations]]></acronim><duration>01.06.2014 - 31.05.2018</duration><status>Završio</status><financ_value>82.462,99 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Matematika, </scie_field_hr><scie_field_en>Mathematics, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>5930, 5518, 6295, 5512, 5479, 5954, 17808, </team_members_id><team_members_names><![CDATA[Mladen Božičević, Hrvoje Kraljevic, Matija Bašić, Ksenija Kitanov, Rafael Mrđen, Ana Prlić, Karmen Grizelj, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[Harish-Chandra modules, Dirac operators, cohomology, Dirac induction, branching problems]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Dirac operators were introduced into representation theory by Parthasarathy in the 1970s. In the 1990s, Vogan conjectured a strengthening of Parthasarathy&#39;s Dirac inequality, which relates the cohomology of the Dirac operator to the infinitesimal character of the representation. This conjecture was proved in a joint paper with Huang . In further research, in part joint with various collaborators (Barbasch, Huang, Kang, Mehdi, Protsak, Renard, Somberg, Zhu) , we related Dirac cohomology to other kinds of cohomology, calculated it explicitly for many interesting representations, and studied algebraic Dirac induction, a construction of representations with given Dirac cohomology. The proposed project will continue this research in several directions: 1) the study of representations obtained by Dirac induction, in particular the discrete series representations (doctoral research of Ana Prlić). 2) applying Dirac cohomology to problems of restricting representations. Some instances of this have been studied with Huang-Zhu and with Somberg. 3) trying to strengthen the Dirac inequality, which should have implications for the study of unitary representations. Some preliminary work on  the convex hull conjecture of Salamanca-Vogan has been done with Renard. 4) calculating the Dirac cohomology of  unipotent representations. Some cases of this have been obtained jointly with Barbasch. This could lead to better understanding of characters of unipotent representations, which is related to the Assem conjecture. It would also be interesting to calculate the Dirac cohomology of unitary highest weight modules. Other topics we plan to cover include studying translation principle for Dirac index (joint with Mehdi and Vogan); studying n-cohomology and BGG resolutions using Penrose transforms (joint with Soucek);  studying some abstract homotopy and homology theory, with applications to tensor categories of representations (doctoral research of Matija Bašić).]]></summary_en></project><project>
<id>1987</id><title_hr><![CDATA[Nastava i škola za net-generacije: unutarnja reforma nastave u osnovnim i srednjim školama]]></title_hr><title_en><![CDATA[School for Net-generation: Internal Reform of Primary and Secondary School Education]]></title_en><user_id>814</user_id><user_firstLast_name>Milan Matijević</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2013-11</proposal_call><code>IP-2013-11-3814</code><acronim><![CDATA[SCHOOL 4 NET-GEN]]></acronim><duration>01.09.2014 - 31.08.2017</duration><status>Završio</status><financ_value>52.460,88 eur</financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Pedagogija, </scie_field_hr><scie_field_en>Pedagogy, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Učiteljski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Teacher Education]]></institution_en><team_members_id>4771, 4809, 4729, 4127, 4126, 4874, 834, 3753, 3382, 18932, 18933, 18938, 18934, </team_members_id><team_members_names><![CDATA[Dubravka Miljković, Višnja Rajić, Mario Dumančić, Damir Velički, Vladimira Velički, Goran Lapat, Tomislav Topolovčan, Siniša Opić, Nevenka Maras, Lidija Eret, Željka Dijanić, Ivana Medica Ružić, Davorka Bačeković-Mitrović, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[digital media, internal reform, net-generation, parents, primary school, principals, secondary school, student centred education, teachers]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[In the last few years, research has shown that the teachers and methodologies in schools today are far from the expectations and needs of students belonging to the Net- Generation. The advantages offered by new digital and communication media are not sufficiently exploited to enhance communication in the classroom, and the course books available to students of elementary and secondary schools are not appropriate to the students&#39; needs and expectations. The main aim of the planned research is to explore the attitudes and (self-)evaluation of teachers, school principals (managers), parents and students about the specific traits of the existing didactical paradigm (teacher-centred education) that still dominates in Croatian schools, and to explore the possible didactical solutions for internal reform that focuses on student-centred education based on contemporary theories of teaching and learning and the possibility to enrich education with ICT.Empirical non-experimental, quasi-experimental, and action research is planned. The following methods of data collection will be used during the research: questionnaires, interviews, focus groups, systematic observation, case studies, and content analysis. A number of stratified student samples (N=3000), teacher samples (N=600) and school principals (N=300) from different counties in the Republic Croatia will be used for data collection. According to the general aim of the research and research problems, a number of research instruments (either constructed by the researchers or already verified) will be employed. In order to apply a holistic approach to the research area, qualitative and quantitative methodology will be used and triangulation will be applied for the purpose of ensuring quality in the data analysis. 	]]></summary_en></project><project>
<id>1991</id><title_hr><![CDATA[Implicitna ličnost i radno ponašanje]]></title_hr><title_en><![CDATA[Implicit personality and work behavior]]></title_en><user_id>3974</user_id><user_firstLast_name>Zvonimir Galic</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2013-11</proposal_call><code>UIP-2013-11-6719</code><acronim><![CDATA[IPAWB]]></acronim><duration>01.10.2014 - 30.09.2017</duration><status>Završio</status><financ_value>48.149,94 eur</financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Psihologija, </scie_field_hr><scie_field_en>Psychology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Filozofski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Humanities and Social Sciences]]></institution_en><team_members_id>4943, 4502, 5480, 5745, 6601, 6848, 4979, </team_members_id><team_members_names><![CDATA[Minja Birimiša Komazec, James LeBreton, Andreja Bubić, Maša Tonković Grabovac, Maja Parmač Kovačić, Željko Jerneić, Nataša Trojak, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[implicit personality, work behavior, conditional reasoning, aggressiveness, power motive.]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Recent developments in implicit personality conceptualization and measurement could shed a new light on the relationship between personality and work behavior and help us explain, predict, and even control important aspects of work behavior. In the focus of this project are conditional reasoning measures of implicit personality that represent “a model for psychometric, conceptual, and theory based implicit association measurement” (Landy, 2008, p. 390). This measurement system is called conditional reasoning because it is based on the assumption that an individual’s reasoning is conditional on his/her personality and that these differences in reasoning can be measured with inductive reasoning tasks capturing unconscious cognitive biases that stem from individuals’ personality motives.The project aims to further advance the knowledge about the conditional reasoning method of personality measurement, and the relationship between (implicit) personality and work behavior by exploring implicit aggression and power motive. We plan to (1) test the implicit nature of conditional reasoning tests and the strength of their relationship with other implicit personality measures intended to assess similar constructs; (2) further explore the relationship between the conditional reasoning tests and work behavior by testing mediators and moderators of that relationship; (3) study how different measures of implicit and explicit personality assessing the same construct (i.e., aggressiveness and power motive) interact in explaining work behaviors. We plan to focus on aggressiveness and power motive because they have the pivotal role in explaining very important aspects of work behavior such as counterproductive work behavior and leadership.]]></summary_en></project><project>
<id>1993</id><title_hr><![CDATA[Razvoj fotokatalitičkih polimernih nanokompozita za obradu otpadnih voda]]></title_hr><title_en><![CDATA[Development of Photocatalytic Polymer Nanocomposites for Wastewater Treatment]]></title_en><user_id>913</user_id><user_firstLast_name>Zlata Hrnjak-Murgić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2013-11</proposal_call><code>IP-2013-11-5092</code><acronim><![CDATA[DePoNPhoto]]></acronim><duration>01.09.2014 - 31.08.2018</duration><status>Završio</status><financ_value>121.481,19 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Kemijsko inženjerstvo, </scie_field_hr><scie_field_en>Chemical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet kemijskog inženjerstva i tehnologije]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Chemical Engineering and Technology]]></institution_en><team_members_id>973, 1437, 1407, 3470, 5174, 17771, </team_members_id><team_members_names><![CDATA[Zvonimir Katančić, Ljerka Kratofil Krehula, Igor Peternel, Jadranka Travas-Sejdic, Mark Žic, Vanja Gilja, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[conducting polymers,  metal oxide nanoparticles, polymer nanocomposites, structure-properties relations, wastewater treatment]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Environmental problems associated with water pollution are an important issue correlated negatively with the health and ecosystem. The main goal of this proposal is to develop novel polymer nanocomposites of extending photoactivity toward visible region under UV/VIS light irradiation and to introduce an innovative technology for water purification. The conducting polymers (CPs) are known as good hole conducting materials1 and are combined with semiconductor nanoparticles to produce a synergistic effect and complementary properties. Due to that Polyaniline (PANI), polypyrrole (PPy) and poly(3,4-ethylene-dioxythiophene) (PEDOT) conducting polymers will be studied with metal oxides (TiO2, ZnO) nanoparticles to develop polymer nanocomposite photocatalysts (CPNPs) with enhanced photocatalytic properties. The optimal structure-properties relationships are crucial for efficient degradation of organic contaminants in water to convert them into harmless chemicals. Novel CPNPs will be applied in photocatalytic degradation of organic azo dyes (reactive red 45 and methyl orange) chosen as targeted wastewater pollutants. The utilization of waste material, fly ash, as a catalyst support will be explored to provide the additional environmental benefit. The proposed integral approach that will be used in the evaluation of the process efficiency will scrutinize any negative implications of CPNPs application. The project will contribute to the development and modernization of science and technology in Croatia, advancing toward the knowledge-based society within the European research area.Project includes a multidisciplinary effort, ranging from polymer science and technology, chemistry and environmental chemistry to electrochemical engineering, in order to meet challenging project tasks and propose an efficient photocatalytic polymer nanocomposite for sustainable water treatment technology. 1. M.R. Karim, C.J. Lee, Y.T. Park, M.S. Lee, J. Polym. Chem. 14 (2006) 5283–5290.]]></summary_en></project><project>
<id>2002</id><title_hr><![CDATA[Perspektive održivosti socijalne države: prema transformaciji sustava socijalne sigurnosti za pojedince u personaliziranoj medicini]]></title_hr><title_en><![CDATA[Perspectives of maintaining the social state: towards the transformation of social security systems for individuals in personalized medicine]]></title_en><user_id>5231</user_id><user_firstLast_name>Nada Bodiroga-Vukobrat</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2013-11</proposal_call><code>IP-2013-11-5709</code><acronim><![CDATA[POMTS]]></acronim><duration>29.12.2014 - 28.12.2018</duration><status>Završio</status><financ_value>76.016,25 eur</financ_value><scie_area_hr>Društvene znanosti, Biomedicina i zdravstvo, Biotehničke znanosti, </scie_area_hr><scie_area_en>Social sciences, Biomedicine and health sciences, Biotechnical sciences, </scie_area_en><scie_field_hr>Pravo, </scie_field_hr><scie_field_en>Law, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Pravni fakultet]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Law]]></institution_en><team_members_id>5119, 5585, 5367, 413, 5762, 6526, 6344, 6701, 6584, 6921, 6165, 2767, 3540, 7358, 7422, 6583, </team_members_id><team_members_names><![CDATA[Matija Miloš, Ana Pošćić, Sanja Barić, Vanja Smokvina, Adrijana Martinović, Dario Đerđa, Jelena Jardas Antonić, Nenad Vretenar, Marija Kaštelan Mrak, Marko Boban, Viktor Peršić, Krešimir Pavelić, Sandra Kraljević Pavelić, Jasmina Mutabžija, Martina Bajcic, Danijela Sokolić, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[transition, social security system, biotechnologies, personalized medicine, reform of the social state]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Knowledge economy and high-end services have a distinct role in the economic system and in transformation of the social state in the context of globalisation. This project will submit the current situation to an interdisciplinary analysis and provide a suggestion of a future scaffolding that will be possible both in legal and in economic terms, at the same time grant the end-user benefits of personalized medicine, biotechnology and cutting-edge research. New biotechnologies are the source of challenges on different levels. In the widest perspective, they promise to bring about the clash of globalization, Europeanization and transition. Focusing on the EU in particular, they may bring about changes in the open methods of coordination and shake up the European social model. The national social state is also likely to be affected.The project will therefore gather biotech, legal and economic experts to deliver a platform for identification of challenges posed by development of new technologies in the field of medicine to the society in general; the way the new technological advances may affect the development of a constitutional democracy and the way the mechanisms of this democracy may affect the new technologies.Important social, regulatory, legal, ethical and moral issues will be analysed within this Project. A central issue to be covered is therefore finding adequate ways for a proper communication between scientists, health care providers, patients and health insurance providers, who all need to understand what they are dealing with in order to define their roles and responsibilities. The objectives of the project address scientific, policy, infrastructure and education issues.  Specific recommendations include: road mapping (defining research agendas); funding (define future Joint programming projects); education; synergies (creation of inter-disciplinary networks); knowledge transfer and communication; impact (through wide dissemination in journals, books, etc.).]]></summary_en></project><project>
<id>2003</id><title_hr><![CDATA[Epigenetičke promjene karcinoma pločastih stanica glave i vrata]]></title_hr><title_en><![CDATA[Epigenetic changes in head and neck squamous cell carcinoma]]></title_en><user_id>572</user_id><user_firstLast_name>Magdalena Grce </user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2013-11</proposal_call><code>IP-2013-11-4758</code><acronim><![CDATA[EpiC-HNSCC]]></acronim><duration>18.06.2014 - 17.10.2018</duration><status>Završio</status><financ_value>99.542,11 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>3294, 898, 4023, 5477, 2696, 2507, 2728, 3949, 17822, </team_members_id><team_members_names><![CDATA[Nina  Milutin Gašperov, Ivan Sabol, Marinka  Mravak-Stipetić, Drago Prgomet, Zoran Rakušić, Antonia Jakovčević, Spomenka Manojlović, Emil Dediol, Ksenija Božinović, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[methylation, microRNA, HPV, head and neck cancer, biomarker]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Head and neck squamous cell carcinoma (HNSCC) is the sixth most common malignancy worldwide. Despite aggressive treatment of HNSCC patients, which entails surgery, chemo- and radio-therapy, the five-year survival is only 40-50%. Tobacco, alcohol, microbial factors (high-risk human papillomaviruses, hrHPVs), systemic factors (immunosuppression, micronutrient deficiency) and UV-radiation are common risk factors for development of HNSCC. HNSCC patients with HPV infection were found to have better prognosis and treatment response. Besides the HPV status, no adequate biomarkers have been found so far to predict the poor/good clinical outcome nor is the mechanism of how HPV modulates therapy response fully understood. Epigenetic changes such as DNA methylation of specific gene promoters and posttranscriptional modification of gene expression by specific microRNA (miRNA) seems to be promising biomarkers of disease occurrence and progression. Therefore, the primary objective of this project is to identify novel specific epigenetic biomarkers to predict early-stage of HNSCC, notably oral and oropharyngeal cancer, patients at greater risk for developing invasive cancer, and finally understand treatment response in patient with HPV-associated cancers. State-of-the-art technologies, wide-genome microarray assay and types-specific validation of DNA methylation and miRNA profiles (methylome and mirome, respectively) will be used on subsets of healthy tissue, HPV-related and HPV-unrelated precancerous oral lesions, oral and oropharyngeal cancer, and metastasis. The integration of all findings should yield ideal epigenetic biomarkers. This project is a comprehensive interdisciplinary research, which includes basic and clinical research, and will enable the improvement of existing knowledge, development of new technological approaches in diagnostics and prognostics, and possible new treatment approach for oral and oropharyngeal cancer.]]></summary_en></project><project>
<id>2017</id><title_hr><![CDATA[Identifikacija i funkcionalna karakterizacija (eko)toksikološki važnih polispecifičnih membranskih transportnih proteina u zebrici (Danio rerio)]]></title_hr><title_en><![CDATA[Identification and functional characterization of (eco)toxicologically relevant polyspecific membrane transport proteins in zebrafish (Danio rerio) ]]></title_en><user_id>986</user_id><user_firstLast_name>Tvrtko Smital</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2013-11</proposal_call><code>IP-2013-11-4806</code><acronim><![CDATA[TRANS-ZEBRATOX]]></acronim><duration>01.10.2014 - 30.04.2018</duration><status>Završio</status><financ_value>108.979,67 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Biologija, </scie_field_hr><scie_field_en>Biology, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>4504, 4272, 1050, 1063, 3923, 17738, </team_members_id><team_members_names><![CDATA[Roko Zaja, Marta Popović, Ivan Mihaljević, Petra Marić, Jovica Lončar, Jelena Dragojević, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[polyspecific uptake and efflux transporters, zebrafish, identification, functional characterization, knockout studies, (eco)toxicological relevance ]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[A coordinated system of transport proteins, channels, receptors and enzymes act as cellular gatekeepers to foreign molecules, critically determining the so-called ADME-Tox (absorption, distribution, metabolism, excretion – toxicity) properties of a molecule. The polyspecific uptake and efflux transmembrane proteins are essential components of this complex cellular defense and detoxification/xenobiotic processing machinery in mammals, highly important and widely recognized in the context of pharmacology and human toxicology. However, they are scarcely investigated in non-mammalian species, and not adequately addressed in the field of environmental toxicology. Consequently, the major goal of the proposed project is identification and detailed functional characterization of new, potentially (eco)toxicologically relevant uptake and efflux transport proteins not addressed so far in the context of environmental toxicology, or in non-mammalian species in general. Our research will be focused on selected polyspecific uptake transport proteins from the SLC21 and SLC22 (Solute Carriers) proteins families, the efflux transporters from the MATE (multidrug and toxic compound extrusion proteins) family, and finally the RLIP76 as the most recently discovered stress-responsive, multi-functional membrane protein. We will use zebrafish (Danio rerio) as a highly relevant vertebrate research model, and our methodological approach will be based on several subsequent research phases: phylogenetic and gene expression analyses; transfection studies in appropriate heterologous expression system(s); transport-activity assays; analyses of the transport mechanism and structural properties; high-throughput-screening identification of chemical interactors of selected transporters among environmental contaminants; and finally in vivo evaluation of the (eco)toxicological relevance of selected transporters using the zebrafish functional genomics tools.]]></summary_en></project><project>
<id>2026</id><title_hr><![CDATA[Mreže javnog komuniciranja u Hrvatskoj: medijatizacija javne sfere i izazovi novih medija]]></title_hr><title_en><![CDATA[Networks of public communication in Croatia: mediatisation of the public sphere and the challenges of new media]]></title_en><user_id>3039</user_id><user_firstLast_name>Nada Švob-Đokić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2013-11</proposal_call><code>IP-2013-11-4014</code><acronim><![CDATA[NETCOMM]]></acronim><duration>01.09.2014 - 31.03.2016</duration><status>Prekinut</status><financ_value>14.424,96 eur</financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Sociologija, </scie_field_hr><scie_field_en>Sociology, </scie_field_en><institution_hr><![CDATA[Institut za razvoj i međunarodne odnose]]></institution_hr><institution_en><![CDATA[Institute for Development and International Relations]]></institution_en><team_members_id>1329, 190, 4507, </team_members_id><team_members_names><![CDATA[Paško Bilić, Ivan Balabanić, Nina Obuljen Koržinek, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[Networks, public communication, public sphere, mediatisation, new media, Croatia]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[The media and society are tightly intertwined in a close and dynamic relationship. Shaped by societies, the media also shape societies. This relationship engenders social change that is at the core of the current mediatisation process and theory debates (Schulz, 2004; Krotz, 2007; Hjarvard, 2008; Hepp, 2011). Networked communication technologies reshape the equilibrium of the media/society relationship and extend the mediatisation process to new directions. The process is not a straightforward technological impact, but a complex accommodation process. In this research we study how the public sphere (Habermas, 1991) has been reshaped through networked communication (Cardoso 2008). We focus on four aspects of mediatisation: extension, substitution, amalgamation and accommodation (Schulz, 2004) to study organizational changes in the process of media production; and media use and practices among internet users. The main objective is to understand processes of media production, consumption and their interrelations, with regard to public communication through new, online and networked media. Specific goals include contributions to development of the mediatisation theory; establishment of a classification of online media in Croatia; development of mixed methods research designs and providing impetus to related public policies. We employ a sequential, explorative research strategy (Creswell, 2009). In the first stage, we conduct multiple, qualitative case studies of the processes of organizational change in different online media. In the second, intermediary stage we construct survey questionnaires based on previous qualitative work. In the third stage, we use a survey on a national representative sample and provide further analytical conclusions derived from the research. The potential users of our research results include: scientific research communities, media industry, media organizations, policy decision-makers, regulatory institutions, and various NGOs.]]></summary_en></project><project>
<id>2027</id><title_hr><![CDATA[Upravljanje povjerenjem i koordinacija interakcija u pametnim mrežama ljudi, strojeva i organizacija]]></title_hr><title_en><![CDATA[Managing Trust and Coordinating Interactions in Smart Networks of People, Machines and Organizations]]></title_en><user_id>2602</user_id><user_firstLast_name>Vedran Podobnik</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2013-11</proposal_call><code>UIP-2013-11-8813</code><acronim><![CDATA[SmartPMONetworks]]></acronim><duration>01.07.2014 - 30.06.2017</duration><status>Prekinut</status><financ_value>109.262,06 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Računarstvo, </scie_field_hr><scie_field_en>Computer sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id>2989, 2612, 5883, 2717, 6404, 6415, 4894, 6453, 20486, 20516, </team_members_id><team_members_names><![CDATA[Iva Bojić, Gordan Ježić, Darko Štriga, Ignac Lovrek, Luka Vrdoljak, Jurica Babić, Marina Bagić Babac, Vanja Smailovic, Goran Jelen, Ivana Rašan, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[social networks, machine-to-machine communication, networked organizations, networked society, trust, coordination, context-awareness, big data]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[We live in a networked society where everything is connected. By 2020 there will be 8 billion people and 50 billion machines in the world and almost all of them will be connected through some kind of network. Furthermore, people and machines that share a certain collective goal will be grouped into some kind of organization, which again will be connected with other organizations and/or people/machines. In order to maintain sustainability of the networked society we need a framework and algorithms which will enable us to i) manage trust; and ii) coordinate interactions in such a complex eco-system consisting of thousands, millions or even billions of interconnected entities. Both the framework and algorithms should be scalable and robust (from the perspective of a network size and heterogeneity), support real-time dynamics (from the perspective of network interactions) as well as be applicable and analyzable at different levels of granularity (at a micro, mezzo and macro network levels). A possible solution for the framework is the “Smart Network”, where people/machines/organizations are represented as nodes which are described by profiles and build a network of connections. The “smartness” of “Smart Networks” stems from profiling nodes and realizing connections using automated computational methods, what is enabled by latest enhancements in information systems and state-of-the-art solutions in communication technologies. The “Smart Network” framework enables design of scalable, robust and real-time algorithms for managing trust and coordinating interactions because it can be i) formally operationalized as a graph where edges represent nodes and vertices represent connections; ii) functionally modeled as a multi-agent system where agents embody edges and relationships embody vertices; and iii) analyzed through complexity theory where sustainable solutions emerge as a result of a bottom-up modeling principle.]]></summary_en></project><project>
<id>2031</id><title_hr><![CDATA[Primjena nanomaterijala u izradi potenciometrijskih tenzidnih senzora za primjenu u industriji i zaštiti okoliša]]></title_hr><title_en><![CDATA[The use of nanomaterials in the construction of potentiometric surfactant sensors for industrial and environmental applications]]></title_en><user_id>4824</user_id><user_firstLast_name>Milan Sak-Bosnar</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2013-11</proposal_call><code>IP-2013-11-9060</code><acronim><![CDATA[NANOSENS]]></acronim><duration>01.07.2014 - 30.06.2017</duration><status>Završio</status><financ_value>72.433,72 eur</financ_value><scie_area_hr>Prirodne znanosti, Tehničke znanosti, </scie_area_hr><scie_area_en>Natural sciences, Technological sciences, </scie_area_en><scie_field_hr>Kemija, </scie_field_hr><scie_field_en>Chemistry, </scie_field_en><institution_hr><![CDATA[Sveučilište Josipa Jurja Strossmayera u Osijeku, Odjel za kemiju]]></institution_hr><institution_en><![CDATA[Josip Juraj Strossmayer University of Osijek, Department of Chemistry]]></institution_en><team_members_id>3613, 4188, 3597, 4397, 4128, 3616, 4919, 3531, 6981, 6620, 7300, 17818, </team_members_id><team_members_names><![CDATA[Mirela Samardžić, Nikola Sakač, Olivera Galović, Marija Jozanović, Sanja Petrušić, Martina Medvidović-Kosanović, Martina Šrajer Gajdošik, Tomislav Balić, Sanja Martinez, Lidija Valek Žulj, Dubravka Madunić-Čačić, MATEJA HAJDUKOVIĆ, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[surfactant, analysis, sensor, potentiometry, nanomaterial, environment, industry]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[The project comprises development and construction of a nanomaterials-based potentiometric surfactant sensor, that will be used for measurement of ionic surfactants concentration in surfactant raw materials, consumer products, pharmaceutical and cosmetic products, environmental materials etc. The new sensor should eliminate the drawbacks of the standard time-consuming extraction-spectrophotometric procedures and classical polymer liquid membrane based sensors. It can be used as an end-point detector by potentiometric titration of ionic surfactants or by their direct potentiometric determination.The new sensor can be also used as a specific detector in microfluidic techniques such as Flow Injection Analysis (FIA), Sequential Injection Analysis (SIA), as well as in the separation techniques (HPLC), substituting in this way more expensive, larger nonspecific detectors such as optical and conductivity detectors etc.]]></summary_en></project><project>
<id>2032</id><title_hr><![CDATA[Tvar i međudjelovanja na ubrzivačima  i u svemiru]]></title_hr><title_en><![CDATA[Matter and Interactions at Accelerators and in Universe]]></title_en><user_id>335</user_id><user_firstLast_name>Krešimir Kumerički</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2013-11</proposal_call><code>IP-2013-11-8799</code><acronim><![CDATA[MIAU]]></acronim><duration>01.06.2014 - 30.09.2018</duration><status>Završio</status><financ_value>105.236,84 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, </scie_field_hr><scie_field_en>Physics, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>5932, 5292, 3358, 3140, 3059, 3183, 5958, 3243, 3129, 3602, 17794, </team_members_id><team_members_names><![CDATA[Sanjin Benić, Ivan Dadić, Davor Horvatić, Amon Ilakovac, Dalibor Kekez, Dubravko  Klabučar, Dieter Mueller, Ivica Picek, Luka Popov, Branimir Radovčić, Petar Čuljak, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[quantum chromodynamics, hadrons, quarks and gluons, quark matter, leptons, neutrino mass, new particles at LHC, dark matter]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[     Hadrons, such as proton or pion, are particles composed ofquarks and gluons which interact through fundamental strongforce. Objective of MIAU project is to contribute to ourunderstanding of this strong force as described by thetheory of quantum chromodynamics (QCD). Additionally, we aimto study physical processes happening at hadronaccelerators, including electroweak production ofas-yet-unseen particles at the large hadron collider (LHC).Thereby, we will investigate models of new physics in whichsuch new particles are introduced in attempts to explainneutrino masses and abundance of dark matter in theuniverse.     To achieve these objectives we will study specific hadronicprocesses, both in the high-energy regime where strong forceis weak enough for perturbative approach, as well as inregimes where non-perturbative features of QCD, such asconfinement and chiral symmetry breaking come to the fore.Our focus will be on processes measured by the range ofexperimental collaborations which will facilitate closecontact with reality and immediate testing of our resultsand ideas.     As outcome, we expect to be able to significantly improvethe knowledge of the quark-gluon structure of the proton, asencoded by the so-called generalized parton distributions,to improve the description of various meson properties invacuum and at finite densities and temperatures, toelucidate QCD phase diagram in model frameworks, and to setbounds to the parameter space of several models of newphysics.]]></summary_en></project><project>
<id>2050</id><title_hr><![CDATA[Utvrđivanje sastava crijevne mikrobiote, upalnih markera, prehrambenog i endokrinog statusa u pacijenata s upalnom bolesti crijeva]]></title_hr><title_en><![CDATA[Assessment of Microbiota, Inflammatory Markers, Nutritional and Endocrinological Status in IBD Patients]]></title_en><user_id>5552</user_id><user_firstLast_name>Donatella Verbanac</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2013-11</proposal_call><code>IP-2013-11-5467</code><acronim><![CDATA[MINUTE for IBD]]></acronim><duration>01.09.2014 - 31.08.2018</duration><status>Završio</status><financ_value>132.510,45 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb School of Medicine]]></institution_en><team_members_id>4214, 5577, 4152, 967, 965, 1278, 6237, 1398, 6406, 5897, 5241, 4012, 1369, 4183, 6297, 4249, 5562, 6316, 13628, 3288, 12582, 13684, </team_members_id><team_members_names><![CDATA[Željko Krznarić, Silvija Čuković-Čavka, Marko  Brinar, Mihaela Perić, Hana Čipčić Paljetak, Mario Matijašić, Vera Kufner, Darija  Vranešić Bender, Nikša Turk, Marija Crnčević Urek, Mirjana Kalauz, Karmen Brajša, Gabrijela Ergović, Anja Barešić, Ivana Kraljević, Dina Ljubas Kelečić, Dora Grgić, Ana Kunovic, Marina Panek, Dunja Rogić, Tomislav Meštrović, Marko Banic, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[IBD, microbiota, blood biomarker, tissue, translational research, clinical research]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Inflammatory bowel disease (IBD) is a chronic gastrointestinal disorder with increase in incidence that severely deteriorates patients’ quality of life. The onset of the disease is mainly associated with the immune status, gut microbiota and food intake. The current scientific knowledge of specific triggers and diagnostic markers is limited; therefore, new data on gut microbiota, inflammatory, endocrine and nutritional status are required to better understand the IBD pathophysiology.It this study we will thoroughly explore host-gut microbiota interactions in order to define novel strategies for management of IBD.We will collect intestine biopsies, stool and blood samples from 40 newly diagnosed IBD patients and 20 non-IBD control individuals, as well as record their nutritional status. Since majority of the gut microorganisms are not culturable, we will use the in house available next-generation sequencing to characterize the composition of the microbiota in collected samples. Moreover, specific blood biomarkers, including cytokines, growth factors and hormones, will be determined using novel and highly sensitive proximity extension assays, recently developed in our laboratories. Collectively, these results will support better stratification of patients and initiate an appropriate therapy.]]></summary_en></project><project>
<id>2054</id><title_hr><![CDATA[Epistemološki modeli hrvatske književne historiografije (1913-1980)]]></title_hr><title_en><![CDATA[Epistemological Models of Croatian Literary Historiography (1913-1980)]]></title_en><user_id>5895</user_id><user_firstLast_name>Leo Rafolt</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2013-11</proposal_call><code>UIP-2013-11-2242</code><acronim><![CDATA[EPISTEMLITHIST]]></acronim><duration>02.06.2014 - 01.06.2017</duration><status>Prekinut</status><financ_value>50.660,30 eur</financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Filologija, </scie_field_hr><scie_field_en>Philology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Filozofski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Humanities and Social Sciences]]></institution_en><team_members_id>5066, 2947, 6647, </team_members_id><team_members_names><![CDATA[Dolores Grmača, Milovan Tatarin, Julijana Matanović, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[epistemology, literary history, theory of literary historiography, Marxist literary history, philological approach, textology, stylistic criticism]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[The project covers one of the most interesting periods of development of the Croatian literary studies. It analyzes it regarding the systems  of knowledge or epistemological matrixes and predominant hermeneutic paradigms in the context of European and Anglo-American literary historiography. Research period is delimited by the year 1913, when one of the first overall synthesis of the Croatian literature was published (B. Vodnik, Povijest hrvatske književnosti), and the year 1980, when the first anthropologically implemented theories of literature occur in our academic context. These two extremes, in the periodical sense, are thus interconnected, primarily because of the hermeneutic concepts announced by the early Croatian literary historians, s.a. Vodnik, Prohaska, Hergešić. The goals of this continuous research activity is to analyze: (1) dominant systems of knowledge significant for the development of Croatian literary historiography, s.a. positivism, folk-psychology, psychoanalysis in its Freudian sense, aestheticism, first phase of the responsive theories, applied sociology of literature, early Marxism, formalist, structuralist, stylistic criticism, early poststructuralism, anthropological tendencies; (2) dominant figures of Croatian literary historiography and their methods, derived from their published works, starting from B. Vodnik, D. Prohaska, T. Matić etc., all the way to I. Slamnig, Ž. Jeličić, M. Vaupotić, I. Frangeš, S. Lasić; (3) dominant figures of our literary historiography and their unpublished oeuvres (s.a. Vodnik, Kombol, Prohaska, Matković), which will be published in a critical form; (4) comparative context of this literary historiography, regarding dominant circles in the 20th century (s.a. Czech and Polish circle, Ljubljana school of literary history, German and Italian academic milieu and its influence on the Zagreb stylistics, French structuralism in Croatian milieu).]]></summary_en></project><project>
<id>2058</id><title_hr><![CDATA[RIMSKODOBNA PREOBRAZBA I UPORABA PRAPOVIJESNIH GRADINA U ISTRI - ANALIZA I STUDIJA SLUČAJA]]></title_hr><title_en><![CDATA[ROMAN AGE TRANSFORMATION AND REUSE OF PREHISTORIC HILLFORTS IN ISTRIA – ANALYSIS AND CASE STUDY]]></title_en><user_id>3231</user_id><user_firstLast_name>Klara Buršić-Matijašić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2013-11</proposal_call><code>IP-2013-11-2370</code><acronim><![CDATA[RAT-ROPH]]></acronim><duration>01.07.2014 - 30.06.2018</duration><status>Završio</status><financ_value>62.081,09 eur</financ_value><scie_area_hr>Humanističke znanosti, Prirodne znanosti, </scie_area_hr><scie_area_en>Humanities, Natural sciences, </scie_area_en><scie_field_hr>Arheologija, </scie_field_hr><scie_field_en>Archeology, </scie_field_en><institution_hr><![CDATA[Sveučilište Jurja Dobrile u Puli]]></institution_hr><institution_en><![CDATA[Juraj Dobrila University of Pula]]></institution_en><team_members_id>5386, 4408, 5306, 5525, 5481, 3440, 823, </team_members_id><team_members_names><![CDATA[Giovanni Boschian, Davor Bulić, Maša Sakara Sučević, Jana Škrgulja, Sandra Šoštarić, Katarina Gerometta, Robert Matijašić, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[Istria, prehistoric hillfort, ancient landscape, roman villa, geoarchaeology, GIS, spatial analysis]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Prehistoric hillforts are characterised by their position on heights with excellent strategic and defensive traits. An impressive number of settlements of this type can be found in Istria, representing an interesting scientific and important cultural phenomenon. Most of the hillforts were established during the Bronze Age, and due to population increase and social stratification they were transformed from simple settlements into pre- and proto-urban centres. While the ethnic identity of the Bronze Age population is still unknown, the ethnically uniform population of the Histri inhabited these settlements during the Iron Age. After the Roman conquest of Istria most hillforts were abandoned; some of them remained in use, but under different circumstances and conditions which led to their substantial modification. Despite the large number of these sites (240 confirmed, 200 hypothetical), few of them were systematically excavated. Previous research was limited to intra-site interpretation and to targeted field survey. The main goals of this project are to identify anthropogenic landscape change at the time of the conversion of site function, and to obtain new insights on the spatial organisation of settlements and their relationships with the surrounding environment. Landscape studies, geoarchaeology, topography and archaeology will be integrated under interdisciplinary GIS environment, providing a new holistic interpretation of past landscape dynamics. This research will fill the gap in the understanding of human-landscape interaction and of anthropic transformation of land from Late Prehistory to Roman times. A case study on human impact on landscape will be conducted in the micro-region of Poreč, and will be explained within its broader regional context. The project will also provide training for young researchers involved in PhD programmes, giving them the chance to develop interdisciplinary skills and encouraging them to become successful independent scientists.]]></summary_en></project><project>
<id>2059</id><title_hr><![CDATA[GRAĐANSKOPRAVNA ZAŠTITA GRAĐANA U FINANCIJSKOJ KRIZI]]></title_hr><title_en><![CDATA[CIVIL LAW PROTECTION OF CITIZENS IN THE FINANCIAL CRISIS]]></title_en><user_id>5005</user_id><user_firstLast_name>Tatjana Josipović</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2013-11</proposal_call><code>IP-2013-11-5269</code><acronim><![CDATA[CitProtect]]></acronim><duration>01.02.2015 - 31.01.2018</duration><status>Završio</status><financ_value>42.421,84 eur</financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Pravo, </scie_field_hr><scie_field_en>Law, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Pravni fakultet u Zagrebu]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Law]]></institution_en><team_members_id>6925, 6935, 5532, 7065, 1042, 1434, 4150, 3842, 235, 3982, 5924, 21146, </team_members_id><team_members_names><![CDATA[Ksenija Grubišić, Siniša Petrović, Igor Gliha, Hano Ernst, Ivana Kanceljak, Ana Keglević, Josip Tica, Saša Nikšić, Iva Kuštrak Managić, Romana Matanovac Vučković, Marko Baretić, Jan Torjanac, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[civil law, protection of citizens, financial crisis, responsible lending, information duty, debt management, debt collection]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[The main, overall aim of this research is twofold. First, the team will analyse the question of the influence of the existing civil law system to the aggravation of the financial difficulties of citizens. Second, the team will analyse the question of potentials of the civil law system for remedying these difficulties and for preventing them in the future. The team shall focus on five objectives: 1. researching the legal model of pre-contractual obligations of traders to inform citizens of their contractual rights and obligations, 2. researching the legal model of responsible lending, 3. researching the model for the protection of citizens in case of a deterioration of the financial situation after agreeing to and/or defaulting on a monetary obligation, 4.researching alternative models of voluntary performance of monetary obligations, and 5. researching the models of civil law protection of citizens in debt collection.The aim of the project is to find optimum measures, both of regulatory and non-regulatory nature, which are necessary to be implemented in order to improve unfortunate financial position of citizens.The research is projected to be undertaken in four consecutive stages or “work packages” (WP’s) in total duration of three years. WP 1 consists of the analysis of the legislation, theory and case law in the field of civil law which has an impact of the current financial crisis of citizens. WP 2 consists of empirical survey. WP 3 consists of the development of recommendations of measures of regulatory and non-regulatory nature which should be implemented in order to improve the existing legal, economic and social environment to the benefit of citizens. WP 4 consists of dissemination of the results of the research.]]></summary_en></project><project>
<id>2063</id><title_hr><![CDATA[Nestali jezerski krajobrazi istočnog dijela Jadranskog mora]]></title_hr><title_en><![CDATA[Lost Lake Landscapes of the Eastern Adriatic Shelf]]></title_en><user_id>162</user_id><user_firstLast_name>Slobodan Miko</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2013-11</proposal_call><code>IP-2013-11-9419</code><acronim><![CDATA[ LoLADRIA]]></acronim><duration>01.07.2014 - 30.06.2018</duration><status>Završio</status><financ_value>104.581,77 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Geologija, </scie_field_hr><scie_field_en>Geology, </scie_field_en><institution_hr><![CDATA[Hrvatski geološki institut]]></institution_hr><institution_en><![CDATA[Croatian Geological Survey]]></institution_en><team_members_id>4970, 3521, 5598, 5844, 5052, 6839, 5740, 5741, 6095, 6065, 3511, 7598, 7588, 7597, 7552, 17774, </team_members_id><team_members_names><![CDATA[Ivan Razum, Valentina Hajek-Tadesse, Dragan Bukovec, Tamara Marković, Nikolina Ilijanić, Ozren Hasan, Vlasta Premec Fućek, Morana Hernitz Kučenjak, Saša Mesić, Martina Šparica Miko, Koraljka Bakrač, George Papatheodorou, Maria Geraga, George Ferentinos, DIMITRIOS CHRISTODOULOU, Dea Brunović, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[Paleolimnology, Paleoclimate, Last Glacial Maximum, Holocene, Pleistocene, Mesolithic, Sea Level Rise, Proxies, Human Migration, Adriatic Shelf, Karst]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[The LoLADRIA project represents a multidisciplinary, effort to recover, for the first time, long paleoenvironmental, and paleoclimate records from existing coastal karst lakes and submerged karstic lakes of the eastern Adriatic shelf in Croatia. The project will attempt to reconstruct the specific karst lake landscapes and their surroundings in view of environmental and climate change and human migration from the Last Glacial Maximum (LGM) through the Holocene. LoLADRIA will provide long, high resolution, paleohydrological reconstructions from a region extremely sensitive to changes in effective moisture and atmospheric dynamics. The multiproxy-based reconstructed curves will provide new data to identify and date the main climate events, and to characterize the climate variability at century and millennium scale since the LGM. Pollen and ostracods offer the possibility to develop transfer functions in order to reconstruct quantitative changes in regional climate and hydrological conditions of the lakes. LoLADRIA will offer an environmental context which enabled the human entrance to Europe along the eastern Adriatic shelf since this pathway is still widely unknown and the detailed framework of climatic and environmental conditions still requires extensive research. In combination with landscape reconstruction based on high resolution geophysical methods will allow the insight to the preserved changes in the landscapes at selected sites along the Eastern Adriatic and their habitability related to the Mesolithic cultures that were present there. Submarine  prehistoric  sites  in  the  Mediterranean  show  that  the  continental  shelf was  occupied  by  humans  to  a  depth  of  at  least  -40m, and the lost (submarine) lakes and surrounding submerged landscapes of the eastern Adriatic have a potential for site discovery.]]></summary_en></project><project>
<id>2065</id><title_hr><![CDATA[Hrvatska srednjovjekovna baština u europskom kontekstu: mobilnost umjetnika i transfer oblika, funkcija i ideja]]></title_hr><title_en><![CDATA[Croatian medieval heritage in European context: mobility of artists and transfer of forms, functions and ideas]]></title_en><user_id>5939</user_id><user_firstLast_name>Miljenko Jurković</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2013-11</proposal_call><code>IP-2013-11-6095</code><acronim><![CDATA[CROMART]]></acronim><duration>15.06.2014 - 14.06.2018</duration><status>Završio</status><financ_value>79.633,69 eur</financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Povijest umjetnosti, </scie_field_hr><scie_field_en>Art history, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Filozofski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Humanities and Social Sciences]]></institution_en><team_members_id>839, 1244, 6253, 4714, 5985, 6944, 5797, 2561, 6375, 6039, 6260, 6090, 6382, 6390, 5523, 6041, 7112, 7157, 6071, 6354, 6026, 6360, 7191, 7320, 7192, 6694, 7362, 6098, </team_members_id><team_members_names><![CDATA[Marijan Bradanović, Ivan Matejčić, Krešimir Karlo, Maurizio Levak, Sunčica Mustač, Ranko Starac, Predrag Marković, Josipa Lulić, Xavier Barral i Altet, Gian Pietro Brogiolo, Jean-Pierre  Caillet, Chevalier Pascale, Morana Čaušević-Bully, Sebastien Bully, Vincenza Lucherini, Jana Maříková-Kubková, Mihailo Milinković, Alejandra Chavarria, stefano riccioni, Angela  Borzacconi, Milagros  Guardia , Carles Mancho, Géraldine Mallet, Terrier Jean, Maja Zeman, Sapin Christian, Joan Molina Figueras, Enrico Cirelli, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[Late antiquity, middle ages, architecture, sculpture, painting, forms, functions, artistic transfers, historical landscape]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[The project puts Croatia in the focus of European research of the middle ages. The international team will implement already elaborated methodologies combined with new technologies (geo-radar, remote sensing) on the medieval artistic heritage of Croatia as to track and map the changes that occurred in monumental landscape in the time span from late antiquity to the late middle ages. Croatia was a border zone between super-powers: eastern and western Roman Empire; Byzantium and respectively Lombard, Carolingian, Ottonian rule; from the 11th c. on, the powers of the West change: the Papacy and Venice, then Hungary. The ecclesiastical and social elites as protagonists of political and diplomatic activities have always strengthened their power by investing and sponsoring architecture and works of art. Those investors often commissioned works of art in their respective countries or summoned architects, sculptors and painters.The main goal of this project is to track down those artists who came from abroad as well as those going out from Croatia and to analyse the origins of the forms and functions of architecture built from late antiquity to the late middle ages. The understanding of the transformation of the Roman world in late antiquity and the early middle Ages, the need to track those changes in a longer time span, even within the growth of the medieval feudal society and to explain the role of the elites becomes fundamental. To answer those questions large field surveys will be carried on as well as the research of elites as investors and carriers of ideas, forms and functions of ecclesiastical architecture. The team is divided in working groups covering different historical regions of Croatia, submitted to very different influences during the middle ages, as well as covering different chronological sequences. By means of thorough field survey, creating catalogue data of architecture, sculpture and painting, through comparative analysis the goal will be achieved. ]]></summary_en></project><project>
<id>2066</id><title_hr><![CDATA[Razvoj naprednih energetski učinkovitih struktura upravljanja generatorom sa stalnim magnetima bez mjernog člana ]]></title_hr><title_en><![CDATA[Development of Advanced Sensorless Control of Permanent Magnet Generator for Improving Energy Efficiency]]></title_en><user_id>5949</user_id><user_firstLast_name>Damir Sumina</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2013-11</proposal_call><code>UIP-2013-11-7601</code><acronim><![CDATA[PMGEFC]]></acronim><duration>01.09.2014 - 30.04.2018</duration><status>Završio</status><financ_value>80.164,58 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Elektrotehnika, </scie_field_hr><scie_field_en>Electrical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id>6380, 6695, 2674, 3279, 17782, 19026, 6481, 22554, </team_members_id><team_members_names><![CDATA[Igor Erceg, Martina Kutija, Ivan Mrčela, Tanja Poljugan, Tin Bariša, Igor Sirotić, Šandor Ileš, Luka Pravica, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[permanent magnet generator,  wind power generation, back-to-back converter, energy efficiency,  sensorless control,]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Renewable energy sources have been attracting great attention due to the cost increase, limited reserves and advanced environmental impact on fossil fuels. In the meantime, technology advancements, cost reduction and governmental incentives have made some renewable energy sources more competitive in the market. Among them, wind energy is the one of the fastest growing renewable energy sources. The conversion of the wind energy into electric energy is of a multidisciplinary nature, involving aerodynamics, mechanical systems, electric machines, power electronics, control theory, and power systems.The main goal of this project is to establish new research group which will improve the quality, performance and competitiveness of industrial sector in the field of wind power generation. The research group has already participated in the project for the development of advanced control structures for induction generator connected via back-to-back-converter to the grid in wind turbine application. As a step forward in innovation, research and development the research focus is set on permanent magnet synchronous generator (PMG) parameter identification, estimation of PMG rotor position using high frequency signal injection and speed estimation. Also, focus is on energy efficient based control method such as model predictive control of PMG. Advanced sensorless control algorithms for PMG will be developed and experimentally verified on the industrial laboratory model. Basic infrastructure for implementation and verification of developed algorithms exists in the Laboratory and for testing of advanced control structures on PMG laboratory model needs to be further upgraded. The final result will be the capability of research group for future cooperation with industrial partners for development of wind power generator systems and other generation systems.]]></summary_en></project><project>
<id>2068</id><title_hr><![CDATA[Nespecifična imunost na hantaviruse]]></title_hr><title_en><![CDATA[Innate immunity to hantaviruses]]></title_en><user_id>5967</user_id><user_firstLast_name>Alemka Markotić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2013-11</proposal_call><code>IP-2013-11-4393</code><acronim><![CDATA[HANTA-INNATE]]></acronim><duration>01.07.2014 - 30.11.2018</duration><status>Završio</status><financ_value>132.059,19 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Ništa od navedenog]]></institution_hr><institution_en><![CDATA[Nothing from this list]]></institution_en><team_members_id>6924, 5654, 5653, 5650, 4412, 7152, 4999, 7127, 5641, </team_members_id><team_members_names><![CDATA[Ofer Mandelboim, Lidija Cvetko Krajinović, Ivan-Christian Kurolt, Ante Tadin, OKTAVIJA ĐAKOVIĆ RODE, Dragan Ledina, ĐURĐICA CEKINOVIĆ, Ljiljana Žmak, Petra Svoboda, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[hantavirses, Puumala, Dobrava, reoinfection, acute infection, monovytes, macrophages, NK cells, innate immunity, hemorrhagic fever with renal syndrome]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Hantaviruses (HTV), family Bunyaviridae, are emerging, enveloped RNA viruses, which cause hemorrhagic fever with renal syndrome (HFRS) in Croatia and in the rest of Europe, where two main HTV cause HFRS: Puumala (PUUV) and Dobrava (DOBV). A broad spectrum of HFRS clinical conditions has been recognized, ranging from inapparent or mild to a fulminant hemorrhagic process with severe renal failure and death. The strong proinflammatory response during acute infection in humans is probably responsible for viral clearance but also for potentially fatal proinflammatory-mediated disease. Innate immunity is the first line of defense to various pathogens which may substantially determine the further development and outcome of disease. There is strong lack of knowledge on innate immune response to HTV in acute phase of disease and no evidence on immune response to reinfection with HTV at all. Overall objective of this project is to identify some key elements of innate immune response in acute HFRS infection and in experimentally simulated HTV reinfection at the level of  monocytes/macrophages, NK cells, their crosstalk, “memory” and potential mediation by microRNAs (miRNAs). For that purpose, ex vivo experiments on peripheral blood mononuclear cells, monocytes/macrophages and NK cells will be performed in patients with acute HFRS and patients previously encountered HFRS. Primary monocytes/macrophages and NK cells will be additionally infected with HTV and co-cultivated. In order to asses potential miRNAs role, some inhibition experiments will be performed. Computational analysis will follow all experimental process in order to generate new data, pursue study in right direction and indicate important signaling pathways for the future research. Such concept may represent the next step in the design of future vaccines for HTV.]]></summary_en></project><project>
<id>2070</id><title_hr><![CDATA[Stvaranje grada: prostor, kultura i identitet]]></title_hr><title_en><![CDATA[CIty-making: space, culture and identity]]></title_en><user_id>1045</user_id><user_firstLast_name>Jasna Čapo Žmegač</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2013-11</proposal_call><code>IP-2013-11-2350</code><acronim><![CDATA[CITID]]></acronim><duration>01.10.2014 - 30.09.2018</duration><status>Završio</status><financ_value>77.642,84 eur</financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Etnologija i antropologija, </scie_field_hr><scie_field_en>Ethnology and anthropology, </scie_field_en><institution_hr><![CDATA[Institut za etnologiju i folkloristiku]]></institution_hr><institution_en><![CDATA[Institute of Ethnology and Folklore Research in Zagreb]]></institution_en><team_members_id>311, 4785, 5400, 4789, 4712, 5288, </team_members_id><team_members_names><![CDATA[Valentina Gulin Zrnić, Nevena Škrbić Alempijević, Laura Šakaja, Tihana Rubić, Petra Kelemen, Sanja Đurin, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[urban anthropology, city, everyday life and culture, politics of space, politics of difference, urban identities, anthropology of migration ]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[The project has emerged from theoretical insights in urban anthropology, anthropology of space and place, urban migration studies, cultural geography, post-socialist studies and post-colonial theory. It proposes a complex research outline based dominantly on qualitative methodology, aiming at untangling and comprehending multiple, multilayered and interdependent (f)actors and processes that influence contemporary transformations in the Croatian capital, Zagreb. The concept of city-making in this research refers to a comprehensive construction and articulation of urban life along two axes—space and diversity. Both constitute nodes at which global political, economic and cultural flows meet and collide with local histories, way of life, imaginaries, interests and developments, bringing about the restructuring of the city and its identity as well as identities of city inhabitants. This ethnological and cultural anthropological project emphasises agency of city dwellers in these transformations and investigates how they negotiate and re-create the given social, cultural, and spatial landscape (cityscape) investing it with meaning and humanising it. The project will have an important bearing on the city&#39;s politics and policies, with the goal of achieving more sustainable and inclusive functioning of the city while, at the same time, it will advance the state of the art of urban studies. In addition, it will ensure the transfer of knowledge via university courses and public presentations aimed at raising the awareness about various urban issues (planning, environment, representation, cultural production, diversity, marginality etc.).]]></summary_en></project><project>
<id>2072</id><title_hr><![CDATA[Istraživanje patoloških procesa u ljudskom ishemičnom miokardu; bazični znanstveni pristup za razumijevanje najčešće bolesti današnjice]]></title_hr><title_en><![CDATA[Investigating Pathological Processes in Ischemic Human Myocardium; Basic Science Tools for Major Health Problem]]></title_en><user_id>187</user_id><user_firstLast_name>Darija Baković Kramarić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2013-11</proposal_call><code>UIP-2013-11-3718</code><acronim><![CDATA[ISTHMUS]]></acronim><duration>01.10.2014 - 30.09.2017</duration><status>Završio</status><financ_value>132.722,81 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Splitu, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Split School of Medicine]]></institution_en><team_members_id>3757, 1026, 168, 1395, 194, 599, 4635, 4715, 4581, </team_members_id><team_members_names><![CDATA[Ana Barać , Tonći Batinić, Marko Ljubković, Damir Fabijanić, Jasna Marinović Ljubković, Cristijan Bulat, Mladen Carev, Mihajlo Lojpur, Lemaire Christophe, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[myocardial ischemia, chronic heart failure, cardiac bioenergetics, cardiomyocyte pathophysiology, cardiac imaging]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Coronary artery disease (CAD), with its clinical representations (angina, acute myocardial infarction and chronic heart failure), is the most common cause of morbidity and mortality in developed world. The pathological remodelling occurring in ischemic myocardium gradually leads to chronic contractile dysfunction and affects many intracellular mechanisms participating in energy production, calcium homeostasis and apoptosis. In the current project, we propose to investigate these pathological processes in patients suffering from the CAD. Patients who are candidates for coronary artery bypass graft surgery will be included and will undergo a detailed cardiac evaluation, which, in addition to standard diagnostic tools, will be enriched by the advanced diagnostic techniques still non-existing in Croatia (stress cardiac magnetic resonance imaging). This will provide accurate identification and quantification of regional myocardial ischemia. Following clinical evaluation and during revascularization surgery, left ventricular biopsies will be taken from characterized ischemic regions, as well as from non-ischemic regions, and a detailed analysis of intracellular energy metabolism, calcium-contractility and endoplasmic reticulum stress will be performed. The Specific Aims of the project are:Aim #1 is to assess regional myocardial perfusion and function in patients with CAD who are considered for revascularization therapy.  Aim #2 will investigate pathological processes affecting mitochondria, calcium homeostasis and endoplasmic reticulum stress that take place in the ischemic parts of myocardium.Aim #3 is to evaluate the effects of the heart rate-lowering pharmacological therapy on ischemic myocardium.Thus, the overreaching aim of this proposal is to investigate intracellular mechanisms underlying myocardial adaptation and remodelling in chronic ischemia and to identify predictors of outcomes in patients with coronary artery disease undergoing revascularization therapy. ]]></summary_en></project><project>
<id>2082</id><title_hr><![CDATA[Definiranje uloge cirkadijurnih gena kod bihevioralne senzitizacije na psihostimulanse kod Drosophile melanogaster]]></title_hr><title_en><![CDATA[Defining the role of circadian genes in behavioral sensitization to psychostimulants in Drosophila melanogaster]]></title_en><user_id>69</user_id><user_firstLast_name>Rozi Andretić Waldowski</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2013-11</proposal_call><code>IP-2013-11-4920</code><acronim><![CDATA[FLYHIGH]]></acronim><duration>01.09.2014 - 31.12.2017</duration><status>Završio</status><financ_value>79.649,26 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Biologija, </scie_field_hr><scie_field_en>Biology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci]]></institution_hr><institution_en><![CDATA[University of Rijeka]]></institution_en><team_members_id>5439, 4624, 5961, </team_members_id><team_members_names><![CDATA[Ralph Greenspan, Ana Filošević, Helija Dokić, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[addiction, psychostimulants, Drosophila, circadian, genes, screen]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Addiction to drugs is a brain disease characterized by changes in the brain functioning caused by repeated drug taking. Repeated drug taking leads to neuroadaptations which over time affect neural networks and change behavior. One such change induced by drugs and commonly studied in lab animals is behavioral sensitization. Regulation of gene expression is one important mechanism by which drugs change the plasticity of the networks which regulate behavior. A group of transcriptional regulators of the molecular circadian clock have been identified to function as regulators of behavioral sensitization to cocaine in Drosophila. Subsequent studies in rodents proved the universality of those genes in mediating drug responses. The genetic pathways and molecular interactions through which circadian genes regulate drug responses has remained undefined.We hypothesize that new genes which interact with circadian genes in the regulation of behavioral sensitization to psychostimulants can be identified in a genetic screen in Drosophila. This is a goal for which Drosophila is perfectly suited, because genetic screens aimed at defining new genes can be performed relatively easy, fast and cheap. Our first aim is to devise a high-throughput method for measuring behavioral sensitization in flies by modifying the existing method for measuring activity. Second, we will undertake a directed behavioral screen by pre-selecting candidates with reported molecular interaction with circadian genes. In the third aim we will use transgenic flies and other genetic tools to investigate neural mechanisms involved in behavioral sensitization. The proposed research is innovative and relevant for human health. New gene candidates isolated in this screen could easily be translated into mammalian research where they will help in further understanding of neuroplastic changes induced by psychostimulants. Given our expertise and available resources the project has great potential to advance the field.]]></summary_en></project><project>
<id>2094</id><title_hr><![CDATA[Stvaranje socijalističkoga čovjeka. Hrvatsko društvo i ideologija jugoslavenskoga socijalizma]]></title_hr><title_en><![CDATA[Making of the Socialist Man. Croatian Society and the ideology of Yugoslav Socialism]]></title_en><user_id>2955</user_id><user_firstLast_name>Igor Duda</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2013-11</proposal_call><code>UIP-2013-11-1718</code><acronim><![CDATA[Socialist Man]]></acronim><duration>15.06.2014 - 14.06.2017</duration><status>Završio</status><financ_value>65.170,22 eur</financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Povijest, </scie_field_hr><scie_field_en>History, </scie_field_en><institution_hr><![CDATA[Sveučilište Jurja Dobrile u Puli]]></institution_hr><institution_en><![CDATA[Juraj Dobrila University of Pula]]></institution_en><team_members_id>3187, 4024, 4494, 3833, 5558, 4286, 4625, 4631, 3429, 4311, </team_members_id><team_members_names><![CDATA[Lada Duraković, Andrea Matošević, Hrvoje Klasić, Snježana Koren, Magdalena Najbar-Agičić, Boris Koroman, Vanessa Vitković Marčeta, Teodora Fonović Cvijanović, Igor Stanić, Anita Buhin, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[socialist society, self-management, ideology in practice, communist indoctrination, Croatia, Yugoslavia]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Making of a “new man” – and woman in the present-day terms – is a concept that has constantly been re-examined and discussed in many political and geographical contexts throughout the twentieth century. The focus of this research project highlights a specific historical situation: the endeavours of Yugoslav authorities in making of a new socialist citizen after the World War II, especially in Croatia as one of the republics forming the Yugoslav Federation. The socialist citizen was first placed in a strongly Soviet-oriented society, but the situation very soon shifted towards a specific kind of Yugoslav self-management and market socialism. The long period of four and a half decades (1945-1990) calls for special attention due to changes in the political system over time: from the formative period of the socialist man to the partial deconstruction of the concept. In many ways Croatia represents an excellent case-study for the research of the Yugoslav society, but in this project it will always be included in the Yugoslav framework and – whenever necessary – in a wider historical context and related comparatively to other socialist societies ruled by communist parties. The academic profile of researchers included in the project guarantees that the new socialist citizen will be closely analyzed in a variety of his or her appearances: from childhood to retirement, in work and leisure or sport, as a creator and a recipient of culture, from the theoretical ideals of high politics to the successful or problematic practices. A wide selection of written, visual and oral sources will be interpreted with a complex multi-disciplinary methodology that includes political, economic, social and cultural history, social and cultural anthropology, cultural studies and linguistics. The aim is to set a new light to the period and topic that are still under-researched by the Croatian and other post-Yugoslav humanities.]]></summary_en></project><project>
<id>2103</id><title_hr><![CDATA[Od protomodernizacije do modernizacije školstva u Hrvatskoj (18. i 19. stoljeće)]]></title_hr><title_en><![CDATA[From Proto-Modernisation to Modernisation of Croatia&#39;s School System (18th and 19th Century)]]></title_en><user_id>232</user_id><user_firstLast_name>Ivana Horbec</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2013-11</proposal_call><code>UIP-2013-11-4919</code><acronim><![CDATA[FPTMOCSS]]></acronim><duration>01.09.2014 - 28.02.2018</duration><status>Završio</status><financ_value>64.874,91 eur</financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Povijest, </scie_field_hr><scie_field_en>History, </scie_field_en><institution_hr><![CDATA[Hrvatski institut za povijest]]></institution_hr><institution_en><![CDATA[Croatian Institute of History]]></institution_en><team_members_id>1526, 4458, 1164, 1311, 990, 948, 4836, </team_members_id><team_members_names><![CDATA[Vlasta Švoger, Dinko Župan, Milan Vrbanus, Robert Skenderović, Maja Matasović, Mislav Gregl, Branko Ostajmer, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[History of Education, Intellectual Transfer, Secularisation, Modernisation, State Education Policy, Habsburg Monarchy]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[School system as an educational subsystem of society touches upon and intertwines with political, economic, scientific, cultural, religious and family subsystems of society. In order to be able to understand societal development it is therefore necessary to understand school legislation and educational institutions which, through secondary socialisation, reproduced the desirable normative frameworks for the society within which they operated. Proto-modernisation and modernisation processes implemented during the 18th and 19th centuries were of key importance for forming the school system as an educational system that became an important factor in the emergence of modern civil societies. A research into the problem area of the school system requires a multidisciplinary and interdisciplinary approach that differs essentially from the researches undertaken thus far and closed within the boundaries of the discipline. The objectives of this project proposal are to determine, using modern methodological approaches and critically analyzing archival material, factors that were of crucial importance in the process of creation and functioning of Croatia’s school system and for the influence this system exerted, to evaluate correlation of Croatia’s school system with the school system in the Habsburg Monarchy and its reflection on the network of power in the society in the period of (proto)modernisation. The project will result in three volumes of documents that were of crucial importance for the development of Croatia&#39;s school system, internet database on students studying at higher schools in the Monarchy, interactive map of educational institutions, a workshop for doctoral students, international scientific conference and an exhibition in the Croatian School Museum. One of the objectives of the project is to create prerequisites for expanding international cooperation and including various topics of history of Croatia&#39;s education in internationally funded projects.]]></summary_en></project><project>
<id>2118</id><title_hr><![CDATA[Uloga ekonomskog sentimenta u tumačenju makroekonomskih trendova: metodološka unapređenja i nova područja primjene]]></title_hr><title_en><![CDATA[The role of economic sentiment in explaining macroeconomic trends: methodological improvements and new areas of application]]></title_en><user_id>4299</user_id><user_firstLast_name>Mirjana Čižmešija</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2013-11</proposal_call><code>IP-2013-11-3858</code><acronim><![CDATA[MCPSIL2484BI]]></acronim><duration>01.09.2014 - 30.09.2018</duration><status>Završio</status><financ_value>67.778,62 eur</financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Ekonomija, </scie_field_hr><scie_field_en>Economy, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Ekonomski fakultet u Zagrebu]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Economics and Business]]></institution_en><team_members_id>4385, 6252, 5144, 5721, 6268, 21201, </team_members_id><team_members_names><![CDATA[Petar Sorić, Ivana Lolić, Nataša Erjavec, Nataša Kurnoga Živadinović, Vlasta Bahovec, Marina Matošec, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[Business and Consumer Surveys, economic sentiment, leading indicators, behavioral economics, nonlinear econometrics]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[The aim of this project is to incorporate psychological sentiment (obtained by Business and Consumer Surveys; BCS) in macroeconomic modeling. Namely, BCS offer direct assessment of the otherwise intangible factors such as economic agents’ perceptions and expectations. They measure the agents’ willingness to consume/invest/save, as opposed to their ability to do the same. Hence these psychological factors are crucial to understand the underlying market forces and agents’ behavior. The project goals are to:- Discern whether the non-rationality of consumers’ inflation expectations stems from the true inability of consumers to anticipate price changes, or did the researchers induce it themselves by falsely assuming that the distribution of BCS responses is normal. - Question whether the poor forecasting accuracy of BCS leading indicators can be improved through obtaining the optimal weights by (non)linear optimization.- Compose an optimism indicator based on BCS responses and determine the nature of its relationship with the stock market returns. Nonlinear time series analysis will be employed to test if the stock market reacts asymmetrically to positive/negative shocks in the economic sentiment.- Estimate the consumers’ willingness to buy realty and econometrically model its relationship with actual real estate prices.- Assess the value of BCS responses on households’ financial distress by correlating them to the common measures of poverty.- Employ the BCS data on managers’ perceptions to construct a liquidity indicator for the Croatian economy.The first 5 goals will be fulfilled by analyzing the proposed issues in EU countries, which will improve the general understanding of the role of sentiment in economic decision-making. Each of the stated research fields is expected to result in the publication of a paper in a reputable international journal. The results empirically obtained for Croatia will be synthesized in a scientific book at the end of the project.]]></summary_en></project><project>
<id>2119</id><title_hr><![CDATA[Genska tipizacija patogena prenosivih krpeljima analizom sekvenici više gena: popunjavanje praznina između životinjskih rezervoara, krpelja i ljudi]]></title_hr><title_en><![CDATA[Multilocus sequence genotyping of tick borne pathogens: covering the gap between animals, ticks and humans]]></title_en><user_id>939</user_id><user_firstLast_name>Relja Beck</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2013-11</proposal_call><code>UIP-2013-11-1957</code><acronim><![CDATA[GENOTICKTRECK]]></acronim><duration>01.09.2014 - 31.08.2017</duration><status>Završio</status><financ_value>127.785,52 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Veterinarska medicina, </scie_field_hr><scie_field_en>Veterinary medicine, </scie_field_en><institution_hr><![CDATA[Hrvatski veterinarski institut]]></institution_hr><institution_en><![CDATA[Croatian Veterinary Institute]]></institution_en><team_members_id>2546, 2597, 2599, 4419, 4117, 3369, 4115, 3991, 1341, 3360, 129, 4239, 2528, 2676, 4412, 2743, 2794, 2608, 4328, 529, 538, 1147, 2582, 3510, 2954, 2570, 21273, 1181, </team_members_id><team_members_names><![CDATA[Lorena Jemeršić, Dragan Brnić, Jelena Prpić, Ana Beck, Mirna Brkljačić, Vesna Matijatko, Marin Torti, Sanja Bosnić, Renata Brezak, Irena Reil, Stjepan Krčmar, Alan Medić, Boris Dželalija, Nenad Pandak, OKTAVIJA ĐAKOVIĆ RODE, Željko Mihaljević, Miroslav Benić, Gordan Kompes, Željko Cvetnić, Silvio Špičić, Ivana Račić, Sanja Duvnjak, Boris Habrun, Krunoslav Pintur, Nikica Šprem, DANKO DEŽĐEK, Maja Stepanić, Doroteja Huber, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[tick-borne pathogens, multilocus sequnce genotyping, pathogen distribution, animals, humans]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Globalization and climate change have an unprecedented worldwide impact on emergence and re-emergence of animal diseases, especially vector borne zoonoses.. Diseases that used to be limited only to tropical areas are now increasingly spreading to other previously unaffected regions. A wide variety of pathogens that can be propagated and transmitted by ticks infect humans, wildlife or domestic animals. Over the past decades, the scientific landscape of tick-borne diseases has changed significantly due to advances in molecular biology. Several new rickettsial and ehrlichial diseases, as well as new Borrelia and Babesia genotypes have been confirmed, and consequently, improved diagnostics of emerging diseases in veterinary and human medicine. A number of cases of tick-borne encephalitis (TBE) and Lyme disease have increased. To better understand the importance of tick-borne diseases, a proposed project follows an interdisciplinary approach involving physicians, veterinarians and biologists, also known as One Health approach. Since the cultivation of pathogens is difficult and slow, and for number of pathogens this cultivation is impossible, multylocus sequence typing MLST approach will be used for their genetic characterization of Babesia spp., Borrelia burgdorferi s. l., B. miyamotoi, Rickettsia spp., Anaplasma spp, Ehrlichia spp. Bartonella spp., Neoehrlichia mikurensis, Tick-borne encephalitis virus, Coxiella burnetii and Francisella tularensis from animal reservoirs, ticks and humans. Another objective will be to map tick species, since they were investigated 40 years ago, and to confirm species with PCR and sequencing. Application of genetic typing of multiple genes allows a detailed differentiation of genotypes and their heterogeneity. In this way, the genetic variability of the isolates, their geographical distribution and population genetic structure, as well as transmission routes of various isolates within ticks and their natural reservoirs, will be defined.]]></summary_en></project><project>
<id>2127</id><title_hr><![CDATA[Hrvatska pravosudna suradnja u kaznenim stvarima u Europskoj uniji i regiji: nasljeđe prošlosti i izazovi budućnosti]]></title_hr><title_en><![CDATA[Croatian Judicial Cooperation in Criminal Matters in the EU and the Region: Heritage of the Past and Challenges of the Future]]></title_en><user_id>6266</user_id><user_firstLast_name>Zlata Đurđević</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2013-11</proposal_call><code>IP-2013-11-8282</code><acronim><![CDATA[CoCoCrim]]></acronim><duration>01.03.2015 - 30.09.2019</duration><status>Završio</status><financ_value>77.339,11 eur</financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Pravo, </scie_field_hr><scie_field_en>Law, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Pravni fakultet u Zagrebu]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Law]]></institution_en><team_members_id>6296, 6657, 3828, 7404, 7173, 7202, 6110, 816, 6285, 7456, 7529, 18963, </team_members_id><team_members_names><![CDATA[Davor Krapac, Elizabeta Ivičević Karas, Maja  Munivrana Vajda, Stjepan  Gluščić, Marin Bonačić, Petar Novoselec, Marija Pleić, Matko Pajčić, Zoran  Burić, Ante Novokmet, Željko Karas, Ivo Josipović, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[judicial cooperation in criminal matters, european criminal law, criminal prosecution of war crimes, regional cooperation, european arrest warrant]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[General objectives of the project are the improvement of Croatian criminal justice system and the advancement in Croatian legal scientific research in the field of judicial cooperation in criminal matters. The improvement of prosecution will occur as regards: a) cooperation with the EU member states, b) regional cooperation. The advancement of Croatian legal scientific research will be realized through scientific activities of research group composed of senior and young researchers from three Croatian universities specialised in the field of EU, international and regional cooperation in criminal matters. Cooperation in the prosecution of war crimes has been a crucial political and legal issue in Croatia in the past two decades. Presently the focus is moved to cooperation with the EU member states. As judicial proceedings before the ICTY were unsustainable without criminal law cooperation of the States, the effective national criminal prosecution today is as well possible only through realization of full and intensive judicial cooperation with the EU member states. Effective cooperation in the prosecution of serious crimes has multiple political and legal values for Croatia, such as credible membership in the EU, stability in the region, and the protection of human rights. It is crucial for the identification of Croatia as a democratic European state that respects the rule of law and does not tolerate any kind of serious crimes. The outcome of the research will be publication of collection of scientific papers on issues related to forms, institutions and problems of the EU and regional judicial cooperation and the level of compliance of Croatian law, judiciary and case law. The research results will be presented at the public round tables and final conference, and implemented in course curriculum at the Croatian Universities. The project will contribute to the training of six young researches and will strengthen mentoring capacities of Croatian law schools.]]></summary_en></project><project>
<id>2129</id><title_hr><![CDATA[PONOVNA UPORABA MULJA S UREĐAJA ZA PROČIŠĆAVANJE OTPADNIH VODA U BETONSKOJ INDUSTRIJI - od mikrostrukture do inovativnih proizvoda]]></title_hr><title_en><![CDATA[REUSE OF SEWAGE SLUDGE IN CONCRETE INDUSTRY - from microstructure to innovative products]]></title_en><user_id>5991</user_id><user_firstLast_name>Dražen Vouk</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2013-11</proposal_call><code>UIP-2013-11-7927</code><acronim><![CDATA[RESCUE]]></acronim><duration>01.09.2014 - 31.08.2017</duration><status>Završio</status><financ_value>63.640,59 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Građevinarstvo, </scie_field_hr><scie_field_en>Civil engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Građevinski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Civil Engineering]]></institution_en><team_members_id>4065, 3406, 6938, 6521, 5060, 6620, 7020, 17785, </team_members_id><team_members_names><![CDATA[Mario  Šiljeg, Nina Štirmer, Davor Malus, Stanislav Tedeschi, Ana Baričević, Lidija Valek Žulj, Christopher Cheeseman, Domagoj Nakić, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[Wastewater treatment, Sewage sludge, ISSA, Concrete, Microstructure, Sustainable materials]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[In the wastewater treatment process, a by-product is generated, as additional waste called sewage sludge (0.5 kg of sludge per 1 m3 of wastewater). Adequate wastewater management implies collection and treatment of wastewater, but also adequate management of waste substances generated in the treatment process. Joining the European Union Croatia has made the commitment to construct all treatment plants of capacities over 10.000 PE by 2018. This will result in putting into operation of treatment plants with the total load of about 4.000.000 PE (250.000.000 m3 of wastewater), which will generate about 215.000 tons per year of raw sewage sludge and after incineration around 49.000 tons per year of incinerated sewer sludge ash (ISSA). Taking into account that EU Directives are limiting the amount of sewage sludge waste to be landfilled, and Waste Framework Directive (2008/98/EC) puts reuse and recycling of waste into the most favorable position, it is evident that enormous amount of ISSA will become available for appropriate management.The composition of the generated sewage sludge and ISSA is dependent on the technology of wastewater and sludge treatment. Reviewing the available knowledge in this field leads to the conclusion that the influence of the method of incineration on physical properties of ISSA and the technology of preparing and processing of concrete and concrete elements has not been fully analysed. The main objective of the project is to investigate the possibilities of recycling the sludge from WWTPs in preparing of new innovative products in concrete industry. Based on comprehensive experimental research and multidisciplinary knowledge of the partners (hydrotecnical, materials and chemical engineering), a strategy will be proposed for the comprehensive and sustainable management of ISSA and its transformation from unwanted waste material into valuable resource for production of construction products with ecological, economical and technological benefits.]]></summary_en></project><project>
<id>2131</id><title_hr><![CDATA[Genetski mehanizmi lizosomalne disfunkcije u Parkinsonovoj bolesti]]></title_hr><title_en><![CDATA[Genetic mechanisms of lysosomal dysfunction in Parkinson&#39;s disease ]]></title_en><user_id>2684</user_id><user_firstLast_name>Fran Borovečki</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2013-11</proposal_call><code>IP-2013-11-9386</code><acronim><![CDATA[LYSOGENE PD]]></acronim><duration>15.07.2014 - 14.12.2018</duration><status>Završio</status><financ_value>132.418,78 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb School of Medicine]]></institution_en><team_members_id>5625, 5619, 5330, 5749, 5959, 4119, 6442, 4818, 19045, 19042, </team_members_id><team_members_names><![CDATA[Zdravka Poljaković, Sanja Hajnšek, Kristina Gotovac, Filip Josip Bingula, Tiago Fleming Outeiro, Maja Relja, Martina Rinčić, Marko Košiček, SRĐANA TELAROVIĆ, Antonela Blažeković, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[Parkinson&#39;s Disease, alpha synuclein, next-generation sequencing, lysosomal dysfunction, iPSC]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Accumulation of misfolded proteins in the brain represents a pathological hallmark of neurodegenerative diseases, suggesting that inadequate clearance of aggregation-prone proteins plays an important role in the disease pathogenesis. The synucleinopathies, including Parkinson’s disease (PD) and dementia with Lewy bodies (LBD), are a group of neurodegenerative disorders characterized by the accumulation and aggregation of a-synuclein (aSyn). Studies on the rare inherited forms of PD caused by mutations in the aSyn gene have highlighted disturbed aSyn clearance through the autophagy-lysosomal pathway (ALP) as a key mechanism leading to PD/LBD. Furthermore, several rare inherited disorders caused by mutations in the lysosomal genes show parkinsonian-like phenotype and accumulation of aSyn, providing additional evidence for the role of lysosomal dysfunction in the pathogenesis of synucleinopathies. The goal of the project is to elucidate the involvement of lysosomal gene mutations and lysosomal dysfunction in the ethiology of PD/LBD. Using the next-generation sequencing and Haloplex-based protocol we will design LYSOGENE platform to anayze genetic mutations/variations in the ALP genes that may lead to and predispose to PD/LBD. The identified ALP mutations will be further characterized in vitro in human neuronal cell lines using the knockdown and overexpression approaches. In particular, we will monitor how the identified mutations affect ALP function, accumulation and aggregation of aSyn, as well as neurotoxicity. Finally, we will validate our mechanistic findings in a biologically relevant model of human dopaminergic neurons derived from the PD/LBD patient’s fibroblasts using the induced pluripotent stem cell technology. Through these studies we will identify genetic variations/mutations in the ALP genes that cause or contribute to PD/LBD. The results of the project may help to identify potential new therapeutic targets for development of neuroprotective treatments.]]></summary_en></project><project>
<id>2144</id><title_hr><![CDATA[Algoritmi za analizu slijeda genoma]]></title_hr><title_en><![CDATA[Algorithms for Genome Sequence Analysis]]></title_en><user_id>1480</user_id><user_firstLast_name>Mile Šikić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2013-11</proposal_call><code>UIP-2013-11-7353</code><acronim><![CDATA[AGESA]]></acronim><duration>01.11.2014 - 31.10.2017</duration><status>Završio</status><financ_value>102.561,55 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Računarstvo, </scie_field_hr><scie_field_en>Computer sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id>7098, 6982, 7322, 18951, 18950, </team_members_id><team_members_names><![CDATA[Niranjan Nagarajan, Damir Seršić, Branko Jeren, Krešimir Križanović, Robert Vaser, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[genome sequence, DNA sequence alignment, RNA-seq mapping, database search, algorithms, GPU]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Twenty years ago, sequencing the human genome was one of the most ambitious science projects ever attempted. Today, DNA and RNA sequencing are now key components of research carried out in many laboratories. The total amount of available genomic data is increasing approximately tenfold every year, a rate much faster than Moore’s Law for computational processing power. The exponential growth of genomic datasets leads to a situation, where computing power becomes a critical issue.The overarching goal of the project is to develop accurate, fast algorithms and tools for analyzing the whole genome-sequencing data. The emphasis of the project is on the output data from the third-generation of sequencing machines that produce longer, more error-prone sequence reads. The basis of the project are sequence alignment algorithms, graph algorithms and signal processing methods. They will be implemented for DNA sequence assembly, sequenced RNA data and sequence similarity database search. The algorithms should feasibly handle data obtained from mammalian and plant genomes (sizes greater than one billion base pairs). Special emphasis will be put on multi-core, many-core and intra-core parallelism. Additionally, the algorithms should provide good scalability over the available underlying computational architecture. All implementations of algorithms will be performed in C/C++. The research will result in the development of novel algorithms tailored to specifications of current and future long-read sequencing data. The implemented methods will further the state-of-the-art of sequence similarity database search, RNA-seq mapping and DNA assembly, ideally providing researchers with methods that return results in feasible time with limited computational resources. This, in turn could affect the current practices of genomic research; help designing new medical strategies and enable faster and more accurate analyses and diagnoses. ]]></summary_en></project><project>
<id>2145</id><title_hr><![CDATA[Anisakis spp: genomska epidemiologija]]></title_hr><title_en><![CDATA[Anisakis spp: genomic epidemiology]]></title_en><user_id>132</user_id><user_firstLast_name>Ivona Mladineo</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2013-11</proposal_call><code>IP-2013-11-5576</code><acronim><![CDATA[AnGEL]]></acronim><duration>30.06.2014 - 29.06.2018</duration><status>Završio</status><financ_value>113.411,64 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Veterinarska medicina, </scie_field_hr><scie_field_en>Veterinary medicine, </scie_field_en><institution_hr><![CDATA[Institut za oceanografiju i ribarstvo]]></institution_hr><institution_en><![CDATA[Institute of Oceanography and Fisheries]]></institution_en><team_members_id>1192, 1305, 996, 4832, 978, 1111, 1029, 1238, 4601, 1127, 2850, 2621, 3610, 3130, 15951, 13683, </team_members_id><team_members_names><![CDATA[Ivana  Bočina, Ivana Bošnjak, Ivana Bušelić, ESMA ČEČUK-JELIČIĆ, Martina Đuras, Andrea Gudan Kurilj, Ivana Lepen Pleić, Diana Nonković, Mirela Petrić, Vedran Poljak, Ivana Radonić, Ingrid Tripković, Željka Trumbić, Ivana Ujević, Romana Roje Busatto, Jerko Hrabar, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[Anisakis spp., zoonosis, seroprevalence, patohistology, transcriptomic, risk analysis]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Global migration and trade of the foodstuff, climate change, novel trends in human eating habits characterised by an elevated demand for raw food, are today considered as major reasons why reports of food borne infections, especially zoonotic parasitosis, have increased in the last decade. Thus the prevention and protection against zoonotic parasites in fishery products designated for human consumption has recently become a priority. Consequently, health authorities and fishing industry have increasingly become aware of the significance of nematode genus Anisakis, which affects human health and the commercial value of fish products. Adriatic fish, marketed fresh, frozen, salted or marinated and exported to EC, are frequently rejected on the border because of Anisakis infection. Although considered one of the most significant emerging food-borne zoonosis, anisakiasis in many Mediterranean countries is still misdiagnosed or underestimated. AnGEL will deepen the knowledge on Anisakis with a multidisciplinary approach, studying the fish as paratenic, cetaceans as the final and men as accidental host. It will start by identifying anisakids species by molecular tools in picarel and damselfish, that are particular dish in culinary tradition of SE Adriatic islands where a significant level of anti-Anisakis IgE in local population was found. It will evaluate histopathological effect of the nematode in the digestive tract of the final host in order to evaluate Anisakis carcinogenic potential, as well as its transciptomic signature during migration through hosts. It will assess larval multixenobiotic resistance mechanisms helping to design more effective therapy, and measure anti-Anisakis seroprevalence in population employed in the fish processing industry by indirect ELISA. Lastly, AnGEL will encompass resulting data in a risk analysis frame, aiming to the design of measures for the safe alimentary seafood production and strengthening of risk communication to stakeholders.]]></summary_en></project><project>
<id>2155</id><title_hr><![CDATA[Istraživanje uloge optineurina u neuroprotekciji]]></title_hr><title_en><![CDATA[Elucidating the Role of Optineurin in Neuroprotection]]></title_en><user_id>4630</user_id><user_firstLast_name>Ivana Munitić </user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2013-11</proposal_call><code>UIP-2013-11-7459</code><acronim><![CDATA[OptineurinNeuroimm]]></acronim><duration>01.09.2014 - 31.12.2017</duration><status>Završio</status><financ_value>131.491,47 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Biologija, </scie_field_hr><scie_field_en>Biology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Fakultet biotehnologije i razvoja lijekova]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Biotechnology and Drug Development]]></institution_en><team_members_id>5775, 6187, 6264, 12500, </team_members_id><team_members_names><![CDATA[Hrvoje Jakovac, Kristina Grabušić, Jonathan Ashwell, Andrea Markovinović, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[cell signalling, autophagy, microglia, neurodegeneration, animal models]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Mutations in a widely expressed ubiquitin-binding protein optineurin were recently found in amyotrophic lateral sclerosis (ALS), a fatal neurodegenerative disease of unresolved pathogenesis. Unlike most of the other mutated proteins known to cause ALS by their toxic prion-like properties, optineurin is largely thought to cause disease by loss-of-function, arguing for its protective role. In vitro studies proposed that it regulates a variety of cellular processes including cell signaling, autophagy and vesicle trafficking, but their link to neurodegeneration is unknown. ALS is not an autonomous disease of selected neurons. Glial cells including microglia, are essential for neuroinflammation, which greatly shapes disease progression. The major aim of this study is to elucidate the exact role(s) whereby optineurin exerts neuroprotection, pinpoint the cell types in which it acts, and determine its putative effect(s) on the interactions between the cell types relevant for neurodegeneration. We aim to dissect these questions in a stepwise fashion by (1) assessing cell-intrinsic functions in neurons, microglia and macrophages, (2) addressing crosstalk in mix-and-match co-cultures and organotypic spinal cord slices, and (3) verifying these findings in mice. To this end, we have generated a novel disease-mimicking genetic mouse model of optineurin insufficiency. Analyzing the function of optineurin in primary cells and mice models is crucial to the success of this study, given that ubiquitin-binding proteins are prone to in vitro artifacts. Incomplete understanding of ALS pathogenesis is directly mirrored in almost complete inability to treat ALS patients: a single approved drug exerts only a small prolongation in survival. Here, we propose to study a unique ALS model, set apart from the currently available models of direct toxicity by its ability to provide insight into basic neuroprotective mechanisms, thus expectedly paving the way for more successful therapies.]]></summary_en></project><project>
<id>2161</id><title_hr><![CDATA[Neomitologizam u kulturi 20. i 21. stoljeća]]></title_hr><title_en><![CDATA[Neomythologism in the Culture of the 20th and 21st Century ]]></title_en><user_id>5143</user_id><user_firstLast_name>Jasmina Vojvodić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2013-11</proposal_call><code>IP-2013-11-6077</code><acronim><![CDATA[Neomyth]]></acronim><duration>01.09.2014 - 31.08.2018</duration><status>Završio</status><financ_value>73.395,71 eur</financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Filologija, </scie_field_hr><scie_field_en>Philology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Filozofski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Humanities and Social Sciences]]></institution_en><team_members_id>3595, 6512, 6551, 6853, 18976, </team_members_id><team_members_names><![CDATA[Danijela Lugarić Vukas, Ivana Peruško, Živa  Benčić-Primc, Josip  Užarević, Zoran Tihomirović, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[neomythologism, contemporary science, Russian literature/culture, Croatian literature/culture, myth, everydayness, Slavic Studies, humanities]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Neomythologism in the culture of the 20th and 21st century is a project proposal designed to study one of the basic phenomena in the contemporary culture and science. The relevance of the topic of neomythologism stems precisely from the crisis in fundamental scientific research and reliance on the phenomenon of irrationality which is happening in the contemporary world. Since there is a crisis in the field of major scientific concepts, man tries to look for answers in a new mythology, which is visible in all forms of cultural research (literary text, visual arts, film, discourse of advertising). This is why this project proposal offers launching of a new type of research into neomythologism. The focus of the proposed research is based on the corpus of Russian and other Slavic literatures, including Croatian, in theatre, visual arts, film culture and contemporary media in order to study and define the elements of neomythologizing, especially those of the myths of everyday life (the myth of youth, the myth of the end of the world, the myth of the family, the myth of a healthy diet). Collection of materials, preparation works, workshops and conferences about the myths of everyday life shall take into account all aspects of this challenging topic in order to research this phenomenon, as well as the concept of the mythical in different aspects of Slavic cultures which are historically interconnected with a common mythology. The aim of the project is, hence, to obtain new scientific knowledge about the phenomenon of neomythologism which, though observable, has not scientifically been considered. ]]></summary_en></project><project>
<id>2163</id><title_hr><![CDATA[Ekonomski, statistički i politički aspekti tržišta državnih obveznica]]></title_hr><title_en><![CDATA[Economic, statistical and political aspects of sovereign bond markets]]></title_en><user_id>603</user_id><user_firstLast_name>Maruška Vizek</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2013-11</proposal_call><code>UIP-2013-11-1356</code><acronim><![CDATA[SOBOM]]></acronim><duration>01.09.2014 - 31.08.2017</duration><status>Završio</status><financ_value>55.805,00 eur</financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Ekonomija, </scie_field_hr><scie_field_en>Economy, </scie_field_en><institution_hr><![CDATA[Ekonomski institut Zagreb]]></institution_hr><institution_en><![CDATA[Institute of Economics in Zagreb]]></institution_en><team_members_id>790, 1066, 733, 606, 983, 17742, </team_members_id><team_members_names><![CDATA[Bojan Basrak, Josip Glaurdić, Petra Posedel, Marina Tkalec, Goran Vukšić, Petra Palić, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[Sovereign bond market, sovereign spreads, volatility spillovers, sovereign bond market integration stochastic volatility models, extreme value theory,]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Recent developments related to the Eurozone debt crisis clearly demonstrated the inability of the literature to provide a theory and associated empirical models that can explain the past and predict the future sovereign bond yield changes. Therefore in this research we investigate the features of the sovereign bond markets that are either underexplored or the literature offers conflicting findings. We focus specifically on bond markets in all EU member states and the US, and differentiate seven research segments that are mutually interrelated. First segment applies GARCH-type models and estimates sovereign bond spread volatility and the volatility risk premium. The output of this segment is used in subsequent segments; in the model of spread determinants, volatility spillovers, and capital flight. Second segment is dedicated to the analysis of the statistical properties of sovereign spreads volatility by an application of extreme value theory, self-exciting and Markov switching models. We quantify extremal dependence between spreads and the distribution of  clusters of their extreme movements using the extremogram. Two segments are devoted to the analysis of volatility spillovers across bond markets and time-varying degree of sovereign bond market integration in developed and emerging EU countries. We also analyze political factors that may influence the sovereign bond market and cross-border capital movement. In this segment we code political variables employed as explanatory variables in the remaining two segments. Hence segment six estimates the model of spread determinants that includes a more balanced and detailed representation of market sentiment and volatility, fiscal features, and political factors. Due to the fact that in recent times extreme changes in sovereign bond markets induced cross-border reallocation of the capital, in the seventh segment we estimate a capital flight model that includes political factors and sovereign spread volatility premium.]]></summary_en></project><project>
<id>2165</id><title_hr><![CDATA[Kulturološke, ekonomske, monetarne i društvene promjene u svjetlu arheološke baštine srednjeg Podunavlja između 279. g. pr. Kr. i 582. g.]]></title_hr><title_en><![CDATA[Cultural, economic, monetary and social transformations in view of the archaeological heritage of the Middle Danubian region 279 B.C. – A.D. 582]]></title_en><user_id>2800</user_id><user_firstLast_name>Tomislav Bilić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2013-11</proposal_call><code>IP-2013-11-1549</code><acronim><![CDATA[ECMS]]></acronim><duration>15.06.2014 - 14.06.2018</duration><status>Završio</status><financ_value>75.784,72 eur</financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Arheologija, </scie_field_hr><scie_field_en>Archeology, </scie_field_en><institution_hr><![CDATA[Ništa od navedenog]]></institution_hr><institution_en><![CDATA[Nothing from this list]]></institution_en><team_members_id>2868, 2804, 4660, 2860, 6690, </team_members_id><team_members_names><![CDATA[Ivan Mirnik, Miroslav  Nađ, Ivan Radman-Livaja, Anja Bertol, Ivan Drnić, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[Middle Danube region, Pannonia, Roman archaeology, numismatics, La Tene period,  Archaeological museum in Zagreb]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[The main goal of the CEMS project would be to focus on the numismatic and archaeological heritage of a geographical area in a given time-frame, i.e. the Middle Danube region from the La Tene B period till the Great Migrations period (between two symbolic dates, 279 B.C., the arrival of the Celts in the Danube basin, and A.D. 582, the fall of Syrmium). Four of the Zagreb Archaeological Museum’s departments have an extremely large number of artefacts from this period found in this particular region, most of which remain unpublished and require a thorough scientific assessment. Therefore, the main emphasis of the project would be on the study and publication of the material kept in the holdings of the Museum.The principal results of the CEMS project would be to publish up to ten monographs on the archaeological and numismatic heritage of the Middle Danube region within a given time frame. These publications would not merely be catalogues of material but would aim to present, following modern methodological approaches in archaeology, ancient history and numismatics, all the cultural, social, economical, monetary and technological transformations that occurred over that fascinating period in a defined geographical area.]]></summary_en></project><project>
<id>2176</id><title_hr><![CDATA[Strateško korištenje prostora]]></title_hr><title_en><![CDATA[Strategic use of landscape]]></title_en><user_id>6496</user_id><user_firstLast_name>Zorko Marković</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2013-11</proposal_call><code>IP-2013-11-3700</code><acronim><![CDATA[Stratuselandscape]]></acronim><duration>01.07.2014 - 30.09.2016</duration><status>Završio</status><financ_value>31.853,47 eur</financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Arheologija, </scie_field_hr><scie_field_en>Archeology, </scie_field_en><institution_hr><![CDATA[Institut za arheologiju]]></institution_hr><institution_en><![CDATA[Institute of Archaeology in Zagreb]]></institution_en><team_members_id>6516, 6838, 7440, 7392, </team_members_id><team_members_names><![CDATA[Katarina Botić, Danimirka Podunavac, Kornelija  Minichreiter, Hrvoje Kalafatić, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[field survey, trial excavation, landscape archaeology, natural resources, Drava region]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Landscape archaeology is developing slowly in Croatia. It is of great importance to speed up this process and to connect the available data to other regions in central-eastern Europe. It is especially important to connect central Balkan regions with Carpathian basin for better understanding of emergence and development of societies in various prehistoric periods. So far, the ways of communication between these regions were not of primary interest of archaeological scientific work. The complete work in defined area, combining field survey, trial excavations and data concerning natural resources, hasn’t been done. The goal of this project is the recognition of strategic points of settlement in prehistory and later periods and reconstruction of ways of communication. The project will concern itself with the area of municipalities Našice, Podgorač, Drenje and Koška (Drava region). This area is recognized as a potential crossroad of ways of communication of our interest. The work will be divided into 4 stages including field survey, trial excavations, data collection from geological maps and satellite images, combining data, web site construction and presenting the results in form of exhibitions, conferences, lectures etc. The final publication will be made presenting goals, collected data, the final results and list of museum activities. The results will also be available on-line in the form of a web site. The project is planned in collaboration with Našice Local History Museum.]]></summary_en></project><project>
<id>2178</id><title_hr><![CDATA[Aktivacijski receptori NK-stanica specifični za virus i njihovo izbjegavanje od strane virusa]]></title_hr><title_en><![CDATA[Virus-specific Activating NK Cell Receptors and Their Viral Immunoevasion]]></title_en><user_id>4958</user_id><user_firstLast_name>Astrid Krmpotić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2013-11</proposal_call><code>IP-2013-11-7132</code><acronim><![CDATA[ViSpeNKRec]]></acronim><duration>01.07.2014 - 31.10.2018</duration><status>Završio</status><financ_value>113.212,56 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Medicine]]></institution_en><team_members_id>5273, 4682, 5131, 4723, 4834, 5357, 4652, 17754, 23184, </team_members_id><team_members_names><![CDATA[Irena Slavuljica, Vanda Juranić Lisnić, Johanna Reichel, Branka Popovic, Ilija Brizić, Daria Kveštak, Berislav Lisnić, Jelena Železnjak, Mia Cesarec, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[NK cells, cytomegalovirus, immunoevasion, Ly49 receptors, KIR receptors, transcriptomics]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[The infection of mice with mouse cytomegalovirus (MCMV) as a model of human CMV (HCMV) infection has been particularly informative in elucidating the role of antiviral immune response. NK cells are essential in early control of CMV infection. An evolutionary struggle between NK cells and CMVs can be inferred from a numerous viral mechanisms designed to compromise NK cell function. A deeper insight was gained by studying MCMV evasion of ‘missing-self’ mechanisms and host response to this immunoevasion, illustrated by several MCMV-specific NK cell activating receptors. The work on Ly49H receptor emphasized the selective pressure imposed on the virus to generate variants no longer recognized by this receptor. Another example can be seen from the function of viral m04 protein, which binds to newly synthesized MHC-I molecules and escorts them to the cell surface to engage inhibitory Ly49 receptors. However, while m04 prevents NK cell activation by escaping ‘missing-self’ recognition, several activating Ly49 receptors also depend on its presence for their own recognition of infected cells. Beside m04, another so far unidentified viral factor is required for turning on the activating Ly49 receptors. In addition to characterization of this new viral gene, the aim of this study is to elucidate the functional significance of MCMV-specific activating Ly49 receptors and their interaction with inhibitory counterparts during primary and latent infection.Ly49 receptors in mice are functional homologues of KIR receptors in humans. Recent studies also indicate a strong impact of HCMV on the repertoire and frequency of activating KIR-expressing NK cells, suggesting their specific response to this virus. Therefore, in addition to the MCMV genes involved in ligation of activating Ly49 receptors, here we also propose study aimed to characterize HCMV gene(s) involved in ligation of activating KIRs. We expect these studies to provide new data of groundbreaking potential in the field.]]></summary_en></project><project>
<id>2179</id><title_hr><![CDATA[3D sustav za mjerenje oblika trupa tijela]]></title_hr><title_en><![CDATA[A low-cost automated system to measure the three-dimensional shape of trunk surface]]></title_en><user_id>6456</user_id><user_firstLast_name>Tomislav Pribanić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2013-11</proposal_call><code>IP-2013-11-3717</code><acronim><![CDATA[3DHumanTorso]]></acronim><duration>03.11.2014 - 02.11.2017</duration><status>Završio</status><financ_value>96.622,20 eur</financ_value><scie_area_hr>Tehničke znanosti, Biomedicina i zdravstvo, </scie_area_hr><scie_area_en>Technological sciences, Biomedicine and health sciences, </scie_area_en><scie_field_hr>Računarstvo, </scie_field_hr><scie_field_en>Computer sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id>6749, 17809, 6641, </team_members_id><team_members_names><![CDATA[Stanislav Peharec, Matea Đonlić, Tomislav Petković, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[3D reconstruction, structured light, passive stereo, scoliosis, degenerative disease, 3D  spine shape]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[The aim of this work is to develop a low-cost automated system to measure the three- dimensional shape of the back and front of the human torso. It will enable numerous physicians to acquire the trunk surface (TS). TS symmetry is one of the key elements in diagnostic and evaluation of various treatments in patients with trunk deformities. Common radiographic evaluation methods are known to expose patients to a radiation and, besides, radiography is actually 2D representation of 3D problem which has been shown not to be directly related to the shape of the back. Thus, there has been a constant motivation among researchers at (inter)national level to develop an optimal methodology for 3D reconstruction of the back. Still, most of those developed systems are mainly directed to 3D reconstruction of the spine and calculation of the Cobb angle which is still regarded by many as the gold standard method to measure scoliotic deformity. Still, the Cobb angle alone cannot explain the whole of the surface deformity. Evidently, there is high need to investigate development of a 3D reconstruction system which will capture both back and front of the patient, i.e. the entire trunk surface. In turn it would enable a more thorough analysis of the patient’s deformity pattern, i.e. a second major goal during this project is to derive other parameters (not only Cobb angle) in order to quantify trunk deformities. In designing 3D system we underline that we plan to research the implementation of both passive and active stereovision strategies. Researching the implementation of combined best features from passive and active stereo for one concrete of 3D system aimed at TS reconstruction (scoliosis), would be a great contribution for potential other 3D applications. Degenerative diseases of spine represent a serious social problem in Croatia. More than 10% of population has frequent problems with it. Clearly, every research contribution for this matter would be an extremely valuable asset.]]></summary_en></project><project>
<id>2182</id><title_hr><![CDATA[Jezična obrada u odraslih govornika]]></title_hr><title_en><![CDATA[Adult language processing]]></title_en><user_id>400</user_id><user_firstLast_name>Jelena Kuvač Kraljević</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2013-11</proposal_call><code>UIP-2013-11-2421</code><acronim><![CDATA[ALP]]></acronim><duration>15.09.2014 - 14.09.2017</duration><status>Završio</status><financ_value>52.312,92 eur</financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Logopedija, </scie_field_hr><scie_field_en>Logopedics, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Edukacijsko-rehabilitacijski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Education and Rehabilitation Sciences]]></institution_en><team_members_id>4359, 6147, 6436, 3759, 3050, 5429, 17791, 20388, </team_members_id><team_members_names><![CDATA[Marijan Palmovic, Gordana Hržica, Melita Kovačević, Sanja  Šimleša, Magdalena Krbot Skoric, KAROLINA LICE, Marina Olujić, Ana  Matić, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[language processing, adult and elderly population, language disorders, executive functions, linguistic aphasiology]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Adult Language Processing project is intended to address psycholinguistic and neurolinguistic aspects of the aging population in Croatia. As an installation research project it will help set up an interdisciplinary and multidisciplinary research group that would tackle all aspects of the language processing in adults and in the aging population. Clinical groups (patients with aphasias, dementias and dyslexia) will be included into the project; language breakdown in these clinical groups helps in the study of language processing in healthy adults and vice versa. It is generally assumed that the subtle changes in language processing in the aging population arise from the cognitive decay related to executive functions, not language per se. The decrease in the processing speed influences language processes that require fast execution or simultaneity. This results in a typical pattern of changes, different from the ones in clinical populations. Therefore, executive functions in these groups will be studied in order to build a comprehensive model of adult language processing. Theories of language processing (namely, Role and Reference Grammar - RRG) will be considered to define specific traces of language processing that assume fast execution or simultaneity and therefore should be the most vulnerable in aging population. These traces will be defined and described which will put Croatian into a cross-linguistic perspective in contemporary studies of linguistic aphasiology and provide coherent picture of age related changes in adult language system.  ]]></summary_en></project><project>
<id>2184</id><title_hr><![CDATA[Problemi temeljnoga suvremenog glazbenog nazivlja u Hrvatskoj]]></title_hr><title_en><![CDATA[Problems of Basic Contemporary Musical Terminology in Croatia]]></title_en><user_id>1454</user_id><user_firstLast_name>Nikša Gligo</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2013-11</proposal_call><code>IP-2013-11-5355</code><acronim><![CDATA[conmusterm]]></acronim><duration>08.09.2014 - 07.09.2018</duration><status>Završio</status><financ_value>37.162,39 eur</financ_value><scie_area_hr>Humanističke znanosti, </scie_area_hr><scie_area_en>Humanities, </scie_area_en><scie_field_hr>Filologija, </scie_field_hr><scie_field_en>Philology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Muzička akademija]]></institution_hr><institution_en><![CDATA[University of Zagreb, Music Academy]]></institution_en><team_members_id>3664, 3395, 5984, 2897, </team_members_id><team_members_names><![CDATA[Tomislava Bošnjak Botica, Krešimir Sučević-Međeral, Sanja Kiš Žuvela, Ana Ostroški Anić, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[musical terminology, Croatian standard language, music education, language standardization, corpus analysis, comparative terminology]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[The project will be dealing with the basic problems of contemporary musical terminology in Croatia.  Aware of the high cultural value of the state-funded music education system in Croatia, as well as an indispensable role of musical metalanguage in teaching music at all levels, the PI Nikša Gligo has noticed an array of doubtful basic musical terms appearing within the above mentioned system. The discrepancies among teaching professionals are so present that it often comes to misunderstandings and other difficulties in communication. The objectives of the project will be to locate problems through analysis of recent corpus of professional literature in the field, to analyse the variants in the use of musical metalanguage among teaching professionals, to compare the Croatian musical terminology with other languages, as well as to propose alternative solutions for inappropriate basic musical terms in daily use. The main aim of the project is to make available to public a set of 2000 standardized and harmonized basic musical terms in form of a free internet database and a published handbook. Further dissemination will follow in form of terminology workshops and seminars throughout Croatia. This interdisciplinary project will be achieved through intensive cooperation of musicologists and linguists, which will ensure a high level of linguistic normativity along with musicological aptness. The PI Gligo is a frequent speaker and the leading author on musical terminology in Croatia.]]></summary_en></project><project>
<id>2185</id><title_hr><![CDATA[STRUKTURNA OBILJEŽJA KOJA ODREĐUJU NUKLEOFUGALNOST IZLAZNIH SKUPINA TE TEORIJSKI MODEL ZA PROCJENU SOLVOLITIČKE REAKTIVNOSTI]]></title_hr><title_en><![CDATA[STRUCTURAL FEATURES THAT DETERMINE THE NUCLEOFUGALITY OF LEAVING GROUPS AND THE THEORETICAL MODEL FOR ESTIMATING THE SOLVOLYTIC REACTIVITY]]></title_en><user_id>2610</user_id><user_firstLast_name>Olga Kronja</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2013-11</proposal_call><code>IP-2013-11-1021</code><acronim><![CDATA[NUCLEOFUGALITY]]></acronim><duration>01.07.2014 - 30.09.2018</duration><status>Završio</status><financ_value>74.285,34 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, </scie_field_hr><scie_field_en>Chemistry, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Farmaceutsko-biokemijski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Pharmacy and Biochemistry]]></institution_en><team_members_id>3221, 3453, 3505, 3946, </team_members_id><team_members_names><![CDATA[Bernard Denegri, Mirela Matić, Sandra Jurić, Marijan Marijan, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[nucleofugality, electrofugality, kinetics, solvolysis, reactivity]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[The impact of electronic effects in the leaving group (nucleofuge) on the overall reactivity will be investigated thoroughly. Importance of negative hyperconjugation, contribution of the leaving group to the height of the reaction intrinsic barrier, importance of the inductivity and resonance as well as solvation will be analyzed. Series of substituted phenyl and alkyl carbonates, phosphates, phenolates, sulfates, phosphorous ylides, quaternary ammonium salts, etc. will be subjected to solvolysis in aqueous solvents and the rate constants will be correlated with the electrofugalities of the generated carbocations by applying a special LFER equation: log k = sf (Nf + Ef). To detect changes of the C—H bond strength in the TS, secondary deuterium KIEs will be determined. The rates of the backward combination reactions in some cases will be measured, which will provide a complete free energy profile of some reactions. The Marcus intrinsic barriers will be calculated and analyzed. The existing electrofugality scale will be extended with other aromatic (e.g. ferocenyl) as well as non-aromatic electrofuges by introducing the correction factors for the solvolysis rates. Such extended electrofugality scale, not limited to aromatic derivatives only, will allowed estimation of the heterolysis rates for wide range of compounds.	The quantum-chemical model will be developed which mimics heterolysis reactions and whose barriers for variety of leaving groups correlate well with experimental barriers obtained with benzhydryl derivatives (?G‡calc vs ?G‡exp). By applying this correlation, the nucleofugality scale will be extended considerably and estimation of the rate constants for SN1 solvolysis of numerous leaving groups will be enabled. Such interplay of the theoretical calculations and experiment will allow prediction of the reactivity of a huge number of new nucleofuges, which have not been used earlier, as well as design of the substrates with required reactivity.]]></summary_en></project><project>
<id>2187</id><title_hr><![CDATA[Dubrovnik: Civitas et Acta Consiliorum, Vizualizacija razvoja kasnosrednjovjekovnog urbanog tkiva]]></title_hr><title_en><![CDATA[Dubrovnik: Civitas et Acta Consiliorum, Visualizing Development of Late Medieval Urban Fabric]]></title_en><user_id>431</user_id><user_firstLast_name>ANA PLOSNIĆ ŠKARIĆ</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2013-11</proposal_call><code>UIP-2013-11-9492</code><acronim><![CDATA[DUCAC]]></acronim><duration>01.10.2014 - 30.09.2017</duration><status>Završio</status><financ_value>52.943,13 eur</financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Povijest umjetnosti, </scie_field_hr><scie_field_en>Art history, </scie_field_en><institution_hr><![CDATA[Institut za povijest umjetnosti]]></institution_hr><institution_en><![CDATA[Institute of Art History, Zagreb]]></institution_en><team_members_id>6995, 5352, 5998, 5497, 7130, 5555, </team_members_id><team_members_names><![CDATA[Nada Grujić, Donatella Calabi, Danko Zelić, Ana Marinković, Alessandra Ferrighi, Matko Matija Marušić, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[new archival data, urban development, changes of tissue, dissemination, comparative perspective, general public, new digital technologies]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[The aim of the DUCAC project is to establish an international, Croatian-Italian group of urban history researchers that would participate in the work, research and discussions within the international community of humanities and social sciences. The project&#39;s main goal is to systematically investigate the unpublished 15th century archival records of Dubrovnik&#39;s three governing bodies (Great Council, Minor council and the Senate) in order to select, gather, interpret and publish data concerning urban spaces and buildings and to examine the relationships between Councils’ deliberations and the urban development. The results would be discussed within the comparative perspective regarding the similar topics of other European towns as well as disseminated within scientific community and general public. These objectives would be established using new digital technologies for the humanities - HGIS interactive database and 3D visual presentations of the related processes.]]></summary_en></project><project>
<id>2189</id><title_hr><![CDATA[Organske molekule u kondenziranoj fazi: međudjelovanja i modeliranje]]></title_hr><title_en><![CDATA[Organic molecules in condensed phase: interactions and modeling]]></title_en><user_id>4668</user_id><user_firstLast_name>Hrvoj Vančik</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2013-11</proposal_call><code>IP-2013-11-7444</code><acronim><![CDATA[ORGMOL]]></acronim><duration>01.09.2014 - 30.11.2018</duration><status>Završio</status><financ_value>99.731,17 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, </scie_field_hr><scie_field_en>Chemistry, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>4679, 4656, 4669, 5069, 4687, 19061, </team_members_id><team_members_names><![CDATA[Zlatko Mihalić, Ivana Biljan, Ivan Kodrin, Igor Rončević, Katarina Varga, Petar Bibulić, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[reaction mechanisms, solvent effects, solid-state reactions, molecular self-assembly, nitroso compounds, ferrocenes]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[This research will consist of two parallel research pathways. The first will include study of mechanisms of organic reactions in the solid state, and the second will mainly deal with the theoretical study of mechanisms in the solution.Mechanisms of the solid-state processes cannot be interpreted using the established concepts of reaction mechanisms because the phase change plays the crucial role in determining reaction kinetics and the structure of the products. Until now, papers published in this field represent mostly kinetics of phase transformations and descriptions of kinetic data by various mathematical models. As a result, the relationship between such a macroscopic approach and structural changes on the molecular level is still poorly understood. Knowledge about the principles of solid-state reactions is of broad interest, and especially useful to chemists who use solvent-free synthetic methods. In this research, we propose investigations of solid-state reactions based on our recent discoveries and explanations of mechanisms of dimerizations and polymerization of nitroso compounds. Using this established approach and corresponding molecular models, we plan to develop a mechanistic concept of the solid-state reactions, and use it to design novel supramolecular structures.As a starting point of our investigations of organic reaction mechanisms in the solution, we will finish development of our new cluster-continuum solvation model. It will provide us with the most important solute-solvent molecules clusters, allowing the realistic estimates of standard Gibbs energies of involved species and thus prediction of kinetic and thermodynamic data for the examined reactions. The approach will be tested on several model problems, and then used for the analysis of several representative organic mechanisms, including the ones occurring in solids.]]></summary_en></project><project>
<id>2193</id><title_hr><![CDATA[Histološka, MRI i analiza genske ekspresije reorganizacijskih procesa u medijalnom (limbičkom) zidu ljudskog mozga tijekom razvitka]]></title_hr><title_en><![CDATA[Histological, MRI and gene expression analysis of the reorganizational processes in the medial (limbic) wall of developing human cerebrum]]></title_en><user_id>3523</user_id><user_firstLast_name>Mario Vukšić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2013-11</proposal_call><code>IP-2013-11-7379</code><acronim><![CDATA[MEDCEREB]]></acronim><duration>01.09.2014 - 31.08.2018</duration><status>Završio</status><financ_value>132.722,81 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb School of Medicine]]></institution_en><team_members_id>6256, 4298, 5534, 4125, 17812, 23386, 22600, </team_members_id><team_members_names><![CDATA[Nataša Jovanov Milošević, Milan Radoš, Zeljka Krsnik, Goran Sedmak, Vinka Kovačević, Damir Mulc, Mihaela Bobić, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[subplate, marginal zone, human brain development, immunohistochemistry, gene expression, in situ hybridization, MRI analysis, hippocampus, cingulum]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[The salient feature of the human fetal cortex is the presence of the subplate zone (SP), a prominent, synapse rich compartment composed of „waiting“ afferents, loosely arranged axons, synapses, growth cones, migratory neurons, glial cells and extraordinary amount of extracellular matric molecules (ECM). The medial (limbic) cortical regions (areas involved in emotion and memory functions) develop a different laminar structure in comparison with lateral cortical regions. Unlike the lateral cortex, where the SP is a major site of neurogenetic events, in the medial archicortex marginal zone (MZ) seems to be a key zone for early molecular neuronal interactions, synaptogenesis and patterning of growing pathways. The goal of this project is to correlate developmental reorganization of major cellular (cell bodies, growing axons) components of the SP and the MZ in developing medial wall of the human cerebrum (cingulum, hippocampus, amygdala) by combining immunochistochemistry, in situ hybridization, transcriptome analysis with in vivo/in vitro MRI. Histological analysis wiil be performed on postmortem human brains, ranging from 10 postconceptional weeks (POW) to 6.5 years, to analyze the expression patterns of different developmentally regulated proteins in relation to synaptic, laminar, neuronal, glial and ECM development. These results will be correlated with in vivo/in vitro MRI findings obtained in age-matched fetuses, infants and children. In addition, we will also analyze publicly available gene expression database (Kang et al., 2011) to investigate the relationship between structural changes and spatio-temporal expression of specific candidate genes. For the selected candidate genes we will perform in situ hybridization and immunocytochemistry in order to elucidate in which cells are these genes expressed. The obtained data will be used for setting the baseline for studying developmental abnormalities characteristic for diverse neurological disorders]]></summary_en></project><project>
<id>2194</id><title_hr><![CDATA[Precizna mjerenja svojstava hadronskih sustava i niskoenergijska QCD]]></title_hr><title_en><![CDATA[High precision measurements of hadronic system properties and low energy QCD]]></title_en><user_id>3809</user_id><user_firstLast_name>Damir Bosnar</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2013-11</proposal_call><code>IP-2013-11-1680</code><acronim><![CDATA[PExpQCD]]></acronim><duration>01.07.2014 - 30.06.2018</duration><status>Završio</status><financ_value>109.230,87 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, </scie_field_hr><scie_field_en>Physics, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>4395, 4413, 5059, 4909, 4993, </team_members_id><team_members_names><![CDATA[Ivica Friščić, Petar Žugec, Gorjana Jerbić-Zorc, Ulrich Müller, Catalina Oana Curceanu, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[electron scattering, nucleon structure, NN correlations, kaonic atoms, low energy QCD]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[In the focus of the project are high precision measurements of specific hadronic system properties relevant for the low energy QCD: electron scattering investigations of nucleons and nuclei at Mainz Microtron (MAMI) and X-ray transitions in kaonic atoms at DAPHE at Laboratori Nazionali di Frascati (LNF). The ultimate goal of the proposed experiments, together with other experimental and theoretical investigations, is to provide crucial pieces of information for the understanding how hadrons emerge from their fundamental constituents - the quarks and gluons, why the colour is confined, the symmetry is spontaneously broken and the nucleon is much heavier than its constituents. The main objectives in electron scattering experiments at MAMI are: cross section determination of the p(e,e’ ?+)n reaction at Q2=0.078 (GeV/c)2, the lowest measured value till now, of crucial relevance for axial nucleon form factor determination, measurements of virtual Compton scattering in the momentum transfer range of relevance for nucleon structure determination, investigations of 12C(e,epp)10Be and  simultaneous measurement of 12C(e,epp)10Be and 12C(e,e’pn)10B reactions of relevance for determination of the role of quark degrees of freedom in nuclei and also for understanding of cold dense nuclear systems such as neutron stars. The main objectives in the kaonic atoms experiments at LNF are: upgrade of SIDDHARTA setup in order to reach desired resolution and subsequently high precision measurements of transitions in kaonic deuterium, 3He and 4He, that should yield isospin dependent kaon-nucleon scattering lengths. Their precise determination will put strong constraints on the low-energy kaon-nucleon dynamics and eventually constrain the SU(3) description of chiral symmetry breaking. Important component of the project proposal is also development of new detector systems, in particular silicon detector system and diamond detector system with data acquisition based on fast digitizers.]]></summary_en></project><project>
<id>2195</id><title_hr><![CDATA[Razvoj naprednih visokonaponskih sustava primjenom novih informacijskih i komunikacijskih tehnologija]]></title_hr><title_en><![CDATA[Development of advanced high voltage systems by application of new information and communication technologies]]></title_en><user_id>5632</user_id><user_firstLast_name>IVO UGLEŠIĆ</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2013-11</proposal_call><code>IP-2013-11-9299</code><acronim><![CDATA[DAHVAT]]></acronim><duration>01.09.2014 - 31.08.2018</duration><status>Završio</status><financ_value>63.504,94 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Elektrotehnika, </scie_field_hr><scie_field_en>Electrical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id>3614, 5633, 3670, 1373, 6159, 6804, 6797, 5760, </team_members_id><team_members_names><![CDATA[Viktor Milardić, Božidar  Filipović-Grčić, Boško Milešević, Dalibor Filipović-Grčić, Bojan Franc, Ivica Pavić, Bruno Jurišić, Milivoj Mandić, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[high voltage, electric raliway, power quality, EMC, modelling, ICT]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[The Research Project will develop the following implementation of new ICT technologies in High Voltage systems: 1. Application of new information and communication technologies such as lightning location system data for analysis of lightning overvoltages and overvoltage protection optimization:- Develop an original algorithm for lightning location data analyze in order to determinate the lightning flashes from the lightning strokes. - Analyze of collected lightning location date and develop an original algorithm for correlation with protection relay tripping in transmission and distribution lines. 2. Modeling the consumers with a big influence on the power quality in high voltage system- Influence of electric railway system on power quality in 110 kV transmission system.- Model of 25 kV 50 Hz electric railway system for power quality studies (electric locomotive, traction network, traction substation):- Compare the developed model with measurement results obtained on locomotives, electric trains and in electric traction substations.  3. New methods for the assessment of Electromagnetic Compatibility - Methodology for more precise electromagnetic influence calculation of contact line and electric traction system to the metal structure in the vicinity:- Identification and assessing the effect of changing values of model parameters based on the theory of electrical circuits to calculate the induced voltage.4. New models of components in studies of electromagnetic transients in high voltage systems- Development of wideband models for power system components (power and instrument transformers, circuit breakers, surge arresters, shunt reactors).- Summarize and analyze the detailed bibliography on the high frequency electromagnetic behavior of transformers (calculations and measurements). - High frequency transformer modeling.]]></summary_en></project><project>
<id>2203</id><title_hr><![CDATA[Upotreba cijelog genoma mitohondrijske DNA u oplemenjivanju i konzervacijskoj genetici goveda]]></title_hr><title_en><![CDATA[Utilisation of the whole mitogenome in cattle breeding and conservation genetics]]></title_en><user_id>6650</user_id><user_firstLast_name>Ino Čurik</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2013-11</proposal_call><code>IP-2013-11-9070</code><acronim><![CDATA[MitoTAUROmics]]></acronim><duration>01.07.2014 - 30.10.2018</duration><status>Završio</status><financ_value>121.093,37 eur</financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Poljoprivreda, </scie_field_hr><scie_field_en>Agriculture, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Agronomski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Agriculture]]></institution_en><team_members_id>4140, 6553, 7105, 539, 6279, 7067, 7343, 7372, 7206, 7401, 17837, 19007, 1339, 6771, 7242, </team_members_id><team_members_names><![CDATA[Strahil Ristov, Anamarija Smetko, Johann Sölkner, Nikola Raguž, Maja Ferenčaković, Ivana Kovač, Vlatka Čubrić Čurik, Mato Čačić, Gregor Gorjanc, Antun Kostelić, Martin Reljanović, Vladimir Brajković, Dinko Novosel, Marija Špehar, Dragica Šalamon, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[Whole mitogenome, Cattle, Detrimental effects, Phenotypic variability, Quantitative genetics]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[The main goal of this proposal is to sequence mitochondrial whole genome (mtWGS) in a 500 to 600 bulls or cows (440 to 540 belonging to Istrian cattle, Busha cattle, Slavonian-Syrmian Podolian cattle and Holstein population in Croatia) in order to: 1). identify polymorphic sites within mtWGS in genetically small populations and to analyse (confirm) the presence of selection for the whole mitochondrial genome as well as for each single gene (comparison of non-synonymous versus synonymous mutations); 2). Identify potentially detrimental mutations and to estimate detrimental load in all analysed populations; 3.) develop computerised approach (set of algorithms) that will, in terms of probability or likelihood, enable imputation of sequenced mtWGS haplotypes for other pedigree members as well as to point to animals that are wrongly assigned to the pedigree, 4.) Identify mutations that are associated with phenotypic variability of milk production and fertility traits and to estimate the magnitude of the mtWGS effects (haplotypes) in terms of variance components and 5.) Identify private (specific) mutations that can be used in traceability or genetic bar-coding of species and breeds (this is of particular interest for endangered populations). In performing these comprehensive analyses we will use newly developed methodologies of high-throughput sequencing and complex computing analyses. We believe that this research will stimulate other researchers involved in animal genetics and breeding of other species (dog, horse, swine, rabbit, etc…) for similar researches. Furthermore, results of the project will be economically utilised in cattle breeding as well as conservation management of endangered Croatian breeds. At the same time, we hope that innovative and technologically advanced component of this research will result in good publication record for all scientists involved which will further increase our competitiveness to approach to EU funded projects.]]></summary_en></project><project>
<id>2209</id><title_hr><![CDATA[Antički vodni sustavi grada Salone i Dioklecijanove palače i njihov utjecaj na održivost urbane sredine]]></title_hr><title_en><![CDATA[Roman Water Systems of City of Salona and Diocletian&#39;s Palace and Their Impact on Urban Sustainability]]></title_en><user_id>6669</user_id><user_firstLast_name>Jure Margeta</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2013-11</proposal_call><code>IP-2013-11-9852</code><acronim><![CDATA[RWSCSDP]]></acronim><duration>01.09.2014 - 31.12.2018</duration><status>Završio</status><financ_value>77.178,31 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Arhitektura i urbanizam, </scie_field_hr><scie_field_en>Architecture and Urban Environment, </scie_field_en><institution_hr><![CDATA[Sveučilište u Splitu Fakultet građevinarstva, arhitekture i geodezije]]></institution_hr><institution_en><![CDATA[University of Split, Faculty of Civil Engineering, Architecture and Geodesy]]></institution_en><team_members_id>6671, 6575, 6674, 6871, </team_members_id><team_members_names><![CDATA[Katja Marasovic, Snježana Perojević, Miroslav Katić, Davor Bojanić, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[Urban water system, Salona, Diocletian&#39;s palace, Aqueduct, Sewage]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[The aim of the project is to study two Roman Water Systems which are using the same water source - Jadro spring. First one is Water System of Salona, capital of Roman province Dalmatia, from the 1st century, and the second one is of Diocletian&#39;s Palace in Split from 4th century. The study will consist of analysis and reconstruction of two, by its purpose, different Water System, one of typical urban character and another very specific of Emperor Palace. Unlike the Water System of the Palace, which is partly preserved (aqueduct is in function) and therefore more studied, the Water System of Salona is mostly unknown. They will be studied separately using the same methodology.All parts of Water Supply system will be studied: water intake on Jadro spring, route and elements of the aqueduct (channel, bridges and tunnels), water distribution tanks, lead pipe network and water appliances together with water quantity and quality issues. The study of sewage will consider wastewater and storm water drainage, as well as the protection from external surface water and groundwater. Besides those, methods, materials and techniques used by Roman engineers to establish efficient urban Water System indispensable for the life and health of the citizens will be analyzed and compared with modern system. The study will be based on collecting all data regarding explored elements of the Water System and on new archaeological excavations financed by this project. Existing topographic and architectonic surveys will be summarized and supplemented by new ones which will enable reconstruction of the whole system and elements. The project team is multidisciplinary and gathers civil engineers, architects and archaeologist. Apart from new knowledge about the planning, building and maintaining Roman Water Systems this project will give necessary data to protect elements of the system form devastation, to make a proper presentation and even to put some elements is use. ]]></summary_en></project><project>
<id>2210</id><title_hr><![CDATA[Održivi optički komunikacijski i senzorski sustavi zasnovani na rezonatoru s produženom rezonantnom šupljinom]]></title_hr><title_en><![CDATA[Sustainable Optical Communication and Sensor Systems based on Extended-Cavity Resonators]]></title_en><user_id>6686</user_id><user_firstLast_name>Zvonimir Šipuš</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2013-11</proposal_call><code>IP-2013-11-3425</code><acronim><![CDATA[EXCAR]]></acronim><duration>01.09.2014 - 31.08.2018</duration><status>Završio</status><financ_value>118.707,28 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Elektrotehnika, </scie_field_hr><scie_field_en>Electrical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id>7148, 7044, 6893, 6886, 6949, 19032, 20069, </team_members_id><team_members_names><![CDATA[Dubravko Babic, Borivoj Modlic, Marko Bosiljevac, Dario Bojanjac, Damir Muha, Marko Šprem, Josip Lončar, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[optical access networks, WDM-PON, optical sensors, colorless optical transmitter, extended cavity, optical noise, noise reduction, wavelength re-use]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[The objective of this project is to advance the state-of-the-art in optical access networks and also apply the same ideas to sensor networks. Proposed project addresses the EU targets as defined by European Commission’s “Europe 2020” strategy for smart growth by focusing on research and development of highly-integrated and energy efficient optical transceivers and wavelength-division-multiplexing (WDM) components for next-generation of access and mobile backhaul networks using passive optical network (PON) infrastructure. The primary challenge, in wider adoption of WDM-PON, lies in the development of sufficiently low cost technology to be used at the users’ premises. Self-seeded WDM-PON has been actively investigated in recent years as potentially the lowest cost solution for next-generation access networks. The primary attraction of this architecture is its simplicity, lower power consumption, and cost advantage. Similar principles can be applied to multiplexing and interrogation systems for optical sensors and our aim is to develop, analyze and demonstrate sustainable all-optical infrastructure based on extended cavity resonators able to provide physical layer for both, access communication and sensor networks.At University of Zagreb we invented an optical component, the modulation-averaging reflector, which reduces the penalty due to modulation of the seeding light and depolarizes the light oscillating in the cavity thereby stabilizing the extended resonator. This was the first step towards a future-proof optical access technology. Within this project we will fully develop and characterize systems based on extended cavity resonators with modulation averaging reflectors. We will also explore the use of modulation averaging concept in a novel communication optical source architecture based on wavelength re-use. Finally, the concept of extended cavity resonators will also be implemented in non-communication applications such as new optical sensor schemes.]]></summary_en></project><project>
<id>2213</id><title_hr><![CDATA[Gravitacija i narušenje pariteta]]></title_hr><title_en><![CDATA[Gravity and parity violation]]></title_en><user_id>3313</user_id><user_firstLast_name>Maro Cvitan</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2013-11</proposal_call><code>UIP-2013-11-8946</code><acronim><![CDATA[GRAPARION]]></acronim><duration>01.09.2014 - 22.02.2018</duration><status>Završio</status><financ_value>90.640,14 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, </scie_field_hr><scie_field_en>Physics, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>3371, 3433, 3399, 3418, 17858, 20367, 21426, </team_members_id><team_members_names><![CDATA[Ivica Smolić, Predrag Dominis Prester, Silvio Pallua, Loriano Bonora, Tamara Štemberga, Stefano Gregorio Giaccari, Mateo Paulišić, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[gravity, black holes, parity violation, quantum anomalies, holography, string theory, conformal symmetry, entanglement entropy]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[The effect of parity or charge-parity (CP) violation in gravitational theories has not been extensively studied so far in the literature. Nevertheless this phenomenon might be very important and help explaining the baryon asymmetry of the Universe: our Universe consists of matter, with the negligible amount of antimatter. Despite many attempts a satisfactory explanation for this asymmetry is not yet at hand, although it is generally accepted that the processes responsible for it must violate CP. The qualifying aim of this project is to explore the idea that CP violation may be traced back to gravity. However we believe it is more effective to cope with this problem in the framework of a more general research on parity violating effects in gravity, which we will study by means of modern methods of exploring the gravitational interaction: holography, Kerr black hole horizon-conformal field theory (Kerr-CFT) correspondence, trace anomalies, entanglement entropy, fluid-gravity correspondence. The focus will be in particular on the natural candidates for parity violating gravity processes - the Chern-Simons terms, both pure gravitational and mixed gauge-gravitational ones - using extra-dimension models inspired by the string theory. The expected outcome is a significant increase in understanding the consequences of parity violating gravitational interactions, not only in relation with possible CP violations, but also for other effects, e.g. for corrections to black hole entropy.]]></summary_en></project><project>
<id>2215</id><title_hr><![CDATA[Panorama hrvatske književnosti u Dubrovniku 17. stoljeća]]></title_hr><title_en><![CDATA[A Panorama of Croatian Literature in 17th Century Dubrovnik]]></title_en><user_id>2947</user_id><user_firstLast_name>Milovan Tatarin</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2013-11</proposal_call><code>IP-2013-11-8110</code><acronim><![CDATA[Panorama]]></acronim><duration>01.08.2014 - 31.07.2018</duration><status>Prekinut</status><financ_value>15.198,70 eur</financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Filologija, </scie_field_hr><scie_field_en>Philology, </scie_field_en><institution_hr><![CDATA[Sveučilište Josipa Jurja Strossmayera u Osijeku, Filozofski fakultet]]></institution_hr><institution_en><![CDATA[Josip Juraj Strossmayer University of Osijek, Faculty of Humanities and Social Sciences]]></institution_en><team_members_id></team_members_id><team_members_names><![CDATA[]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[Croatian Literature, Dubrovnik, 17th Century, Critical edition, Tekstology]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Assuming that only the availability of all the works written in the 17th century will allow for a valid interpretation, both of individual oeuvres and of the period as a whole, I decided to use the manuscripts (not the existing printed editions) to prepare for publication the works of all the writers that were active from the end of 16th century until 1637 (death of Injacije Đurđević). We are talking about 42 poets. This project is thus a survey of everything that was written in the 17th century, in all three literary forms (Lyric, Narrative and Drama), excluding the writers that already have their own critical editions (Palmotić, Gleđević, Gundulić, Đurđević, Bunić). The project is substantial since it encompasses: a) collecting and comparison of manuscripts; b) transcribing the manuscripts; c) an accompanying study. This project is neither an anthology nor a chrestomathy, but it strives to collect in one place everything that a certain writer wrote, regardless of the literary value.]]></summary_en></project><project>
<id>2216</id><title_hr><![CDATA[Preobrazba građanskog pravosuđa pod utjecajem globalnih i regionalnih integracijskih procesa. Jedinstvo i različitost]]></title_hr><title_en><![CDATA[Transformation of Civil Justice under the Influence of Global and Regional Integration Processes. Unity and Diversity]]></title_en><user_id>3028</user_id><user_firstLast_name>Alan  Uzelac</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2013-11</proposal_call><code>IP-2013-11-6988</code><acronim><![CDATA[TCJust-UD]]></acronim><duration>01.01.2015 - 31.12.2018</duration><status>Završio</status><financ_value>74.316,10 eur</financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Pravo, </scie_field_hr><scie_field_en>Law, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Pravni fakultet u Zagrebu]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Law]]></institution_en><team_members_id>4219, 3969, 4405, 3341, 5320, 5043, 5032, 3428, 5783, 3062, 5042, 17777, </team_members_id><team_members_names><![CDATA[Cornelis Hendrik van Rhee, Elisabetta Silvestri, Aleš Galič, Aleksandra  Maganić, Marko Petrak, Ivan Milotić, Tomislav Karlović, Slađana Aras, Barbara Preložnjak, Marko Bratković, Henrik-Riko Held, Juraj Brozović, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[civil justice, civil procedure, harmonisation, unification, globalization, integration, ius commune, effective legal protection, legal history]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[National civil justice systems are deeply rooted in national legal culture and traditions. However, in the past few decades they are increasingly under the influence of integration processes at the supra-national, regional and international level. The emergence of economic and political unions and globalisation processes exert as a by-product pressure to harmonise or even unify the way in which national civil justice systems operate. In an attempt to create a ‘genuine area of justice’, new unified procedures are being developed. They operate in parallel with national civil procedures, and sometimes even strive to replace them. As a reaction to the forces that endeavour to harmonise and unify procedural laws and practices, an opposite trend is gaining momentum: a trend that insists on diversity and pluralism of national civil procedures. The basis of this trend is the claim for national procedural autonomy/sovereignty. The research within this project will focus on the evolution of procedural reforms in various jurisdictions, with a particular emphasis on Croatia, its broader region (successor states of the former Yugoslavia) and Europe. The purpose is to identify to what extent the tensions between the centrifugal and centripetal forces contribute to development of judicial structures that provide a higher level of proper and effective legal protection, and to which extent these tensions create confusion and produce legal transplants and irritants that are equally or less effective than traditional procedures.]]></summary_en></project><project>
<id>2224</id><title_hr><![CDATA[Fleksibilna energetska čvorišta u nisko ugljičnim naprednim elektroenergetskim mrežama]]></title_hr><title_en><![CDATA[Flexible energy nodes in low carbon smart grid]]></title_en><user_id>6497</user_id><user_firstLast_name>Igor Kuzle</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2013-11</proposal_call><code>IP-2013-11-7766</code><acronim><![CDATA[FENISG]]></acronim><duration>01.10.2014 - 30.09.2018</duration><status>Završio</status><financ_value>128.528,77 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Elektrotehnika, </scie_field_hr><scie_field_en>Electrical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id>6990, 6996, 7087, 7162, 7186, 7211, 7278, 7348, 7160, 7194, 19028, 22939, </team_members_id><team_members_names><![CDATA[Zeljko Tomsic, Marko Delimar, Davor Škrlec, Hrvoje Pandžić, Ninoslav Holjevac, Miljenko Brezovec, Tomislav Plavšić, Juraj Havelka, Sejid Tešnjak, Matija Zidar, Kristina Jurković, Stjepan Tusun, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[energy/power nodes, smart grids, reneawable energy sources, distributed generation, energy storage, plug in electrical vehicles]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[The share of renewable energy sources (RES) in electric power systems (EPS) has increased during the recent years and this trend is expected to continue. The stochastic nature of electricity production from RES imposes new challenges for the EPS operation and control. A large share of undispatchable RES can lead to significant disturbances of EPS components. These disturbances need to be balanced out and the security of the system has to be preserved. If the resources for providing balancing energy and flexibility are limited, secure operation of the EPS will become highly expensive. Conventional generation units provide the necessary flexibility to maintain a continuous balance between supply and demand. The question is: are these conventional resources the most feasible way of providing system flexibility in the future low carbon systems? During the recent years, plug-in hybrid electric vehicles (PHEV) have become an attractive way of transportation. While passive approach to their integration might cause problems to the system, active utilization of their flexibility might enable higher penetration of RES. A similar reasoning can be applied to the distributed generation, especially technologies with the potential of multi energy vector interaction (efficient electric heating, combined heat and power, battery storage etc.).Current grids need to be capable of dealing with mentioned requirements. The concept of Smart Grid (SG) is based on using of novel information and communication technology (ICT) and includes application of a spectrum of innovative and flexible technologies.The purpose of this project is to establish a methodological and comprehensive framework providing the costs and benefits evaluation of SG projects and technologies. Given the sizeable investments needed, there is a need for a fair, consistent and methodological approach for estimation of the best investment option, taking into account economic and environmental aspects of a specific project.]]></summary_en></project><project>
<id>2225</id><title_hr><![CDATA[Teoretsko i primjenjeno jezikoslovno istraživanje korpusa hrvatskih crkvenoslavenskih tekstova s izradom Rječnika crkvenoslavenskoga jezika hrvatske redakcije]]></title_hr><title_en><![CDATA[Theoretical and applied linguistic research of the corpus of the Croatian Church Slavonic texts with the Dictionary of the Croatian Redaction of Church Slavonic compiling ]]></title_en><user_id>1047</user_id><user_firstLast_name>Vida Vukoja</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2013-11</proposal_call><code>UIP-2013-11-2462</code><acronim><![CDATA[TALRCCCSTDCRCSC]]></acronim><duration>01.07.2014 - 30.06.2018</duration><status>Završio</status><financ_value>48.041,41 eur</financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Filologija, </scie_field_hr><scie_field_en>Philology, </scie_field_en><institution_hr><![CDATA[Staroslavenski institut]]></institution_hr><institution_en><![CDATA[Old Church Slavonic Institute in Zagreb]]></institution_en><team_members_id>1119, 2569, 4724, 6597, 6756, 7397, </team_members_id><team_members_names><![CDATA[Jozo Vela, Lucija Turkalj, Zdenka Ribarova, Anica Nazor, Ana Kovačević, Marija Klenovar, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[Croatian Church Slavonic, (paleo)slavistic studies, (historical) lexicography, Medieval studies, linguistics ]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Croatian Church Slavonic (CCS) is a bookish language system written in Glagolitic script, with the preserved documents originated from the XI/XII to the XVII c., developed on the basis of the Old Church Slavonic (OCS; created by Sst. Cyrill and Methodius), and under heavy influence of the medieval Croatian vernacular. Being referential and representative, the corpus of the CCS texts provides the most effective basis available for the relevant research of the CCS.The project includes theoretical and applied linguistic research. Among the applied linguistic disciplines, two lexicographic tasks play focal roles: compiling of Rječnik crkvenoslavenskoga jezika hrvatske redakcije (Eng. Dictionary of the Croatian Redaction of Church Slavonic; DCRCS) and conversion of the CCS corpus into digitally readable text(s). Theoretical and other, non-lexicographical, applied linguistic research include those within the fields of: semantics (esp. of the lexis expressing feelings/passions), theory and practice of (medieval) translation (direct translation from Latin into CCS, and inherited OCS translations of the Greek texts within the CCS tradition), grammar (primarily syntax of negation, agreement, infinitive, CCS psalter), textology (selected CCS texts, CCS psalter).	Substantial contribution of the project research cover (inter)national fields of: (paleo)slavistic and medieval studies, historical lexicography, diachronic study of the Croatian language diasystem, interdisciplinary investigation of the history of emotions. Finally, through the CCS corpus management (i.e. conversion of the CCS corpus into digitally readable format) and the DCRCS compiling, the project offers irreplaceable and permanent assistance to any scholarly or scientific field interested in the CCS texts contents. Due to the range of texts incorporated into the corpus, this contribution is virtually unforseeable.]]></summary_en></project><project>
<id>2230</id><title_hr><![CDATA[MAtematička analiza multifizikalnih problema koji uključuju tanke i kompozitne strukture i fluide]]></title_hr><title_en><![CDATA[Mathematical Analysis of Multiphysics problems Involving Thin and Composite Structures and Fluids]]></title_en><user_id>6764</user_id><user_firstLast_name>Igor  Velčić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2013-11</proposal_call><code>UIP-2013-11-9477</code><acronim><![CDATA[MAMPITCoStruFl]]></acronim><duration>01.09.2014 - 31.08.2017</duration><status>Završio</status><financ_value>103.935,28 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Matematika, </scie_field_hr><scie_field_en>Mathematics, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id>7180, 5074, 5872, 6840, 4816, 17761, 20370, </team_members_id><team_members_names><![CDATA[Suncica Canic, Boris Muha, Mario Bukal, Maroje Marohnić, Josip Tambača, Marija Galić, Marin Bužančić, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[thin structures, composite structures, dimensional reduction, homogenization, Gamma convergence, fluid-structure interaction, existence of solution ]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Composite materials are materials made from two or more constituent materials with different physical properties that, when combined, produce a material with characteristics different from those of its individual components. Thin and composite structures are of extreme importance for applications in engineering (e.g. building blocks, boats, ships, aircraft design) and biology (bones, biological tissues, blood vessels) where they are often subjected to fluid load. The analysis of these kind of complex multi-physics systems is very challenging from the mathematical point of view. Namely, the analysis of thin and composite structures and fluids includes the analysis of nonlinear partial differential equations (nonlinear PDEs), which leads to interesting mathematical questions (Gamma limits of a certain system of nonlinear equations with highly oscillating coefficients, existence for a certain system of nonlinear PDEs). This project plans the following: derivation of lower dimensional models in elasticity for highly oscillating materials, optimal design problems, derivation and analysis of fluid-structure interaction problems (derivation of coupling conditions, well-posedness and asymptotic stability analysis). We will use both Calculus of Variation and PDEs techniques to approach different topics, using the benefits from both. We strongly believe that this diversity will bring additional value to Croatian applied mathematics and will provide young people to develop and get acquainted with different approaches of the modern applied mathematics.]]></summary_en></project><project>
<id>2232</id><title_hr><![CDATA[Razvoj konkurentnosti hrvatskog prerađivačkog sektora]]></title_hr><title_en><![CDATA[Building competitiveness of Croatian manufacturing]]></title_en><user_id>653</user_id><user_firstLast_name>Jasna Prester</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2013-11</proposal_call><code>IP-2013-11-3535</code><acronim><![CDATA[EMS_GMRG]]></acronim><duration>01.07.2014 - 30.06.2018</duration><status>Završio</status><financ_value>44.921,24 eur</financ_value><scie_area_hr>Društvene znanosti, Tehničke znanosti, </scie_area_hr><scie_area_en>Social sciences, Technological sciences, </scie_area_en><scie_field_hr>Ekonomija, </scie_field_hr><scie_field_en>Economy, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Ekonomski fakultet u Zagrebu]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Economics and Business]]></institution_en><team_members_id>293, 2584, 4422, 4455, 2519, 5210, </team_members_id><team_members_names><![CDATA[Božidar Matijević, Najla  Podrug, IVANA RAŠIĆ BAKARIĆ, Davor Filipović, Maja Daraboš, Ivan Kumić, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[Manufacturing, manufacturing practices, technology, organizational innovations, EMS, GMRG, Croatia]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[There are several trends in global manufacturing. Higher automatization reduces the need for human labour and China manufacturing is posing a considerable threat. Manufacturing companies in developed countries are seeking ways to stay competitive on the global market since a considerable part of their GDP is acquired by manufacturing, but unfortunately, shrinking. At the moment there are two large scale projects exploring manufacturing sector: EMS and GMRG Survey. Both surveys look at different aspects of manufacturing and engage different countries. EMS covers 18, while GMRG survey includes 24 countries including China, Taiwan and others. The main objective for application is to enable Croatian scientist to be equal partners in such large scale projects and access data from other countries and carry out comparative analyses that will benefit the researchers and manufacturing industry in Croatia. It must be emphasized that Faculty of Business and Economics is the partner for both EMS and GMRG project for number of years but never had the chance to exploit the privileges.   Both surveys explore in detail manufacturing so willingness of the industry to participate is essential. In order to do that, Faculty of Business and Economics will have to provide several workshops on which participants will see the comparative results between countries and be motivated to participate in the next round. All the acquired knowledge will be shared with industry experts and all the results will be available on the internet page of the host Institution. The project is interdisciplinary because it investigates the manufacturing technology and processes, as well as the usage of novel materials. Therefore colleagues from Engineering Sciences are participating in the project since the latest results in manufacturing research shows that advanced technology and advanced materials are the only source left for sustaining the competitive advantage in comparison to China.]]></summary_en></project><project>
<id>2246</id><title_hr><![CDATA[Nanominerali u sedimentima i tlima: formiranje, značajke i uloga u biogeokemijskim procesima]]></title_hr><title_en><![CDATA[Nanominerals in sediments and soils: formation, properties and the role in biogeochemical processes.]]></title_en><user_id>6786</user_id><user_firstLast_name>Ivan Sondi</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2013-11</proposal_call><code>IP-2013-11-2504</code><acronim><![CDATA[NanoMin]]></acronim><duration>01.09.2014 - 30.09.2018</duration><status>Završio</status><financ_value>124.111,18 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Geologija, </scie_field_hr><scie_field_en>Geology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Rudarsko-geološko-naftni fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Mining, Geology and Petroleum Engineering]]></institution_en><team_members_id>2669, 4675, 6573, 2885, 2920, 624, 6464, 3252, 614, 4415, 3030, 6023, 20538, </team_members_id><team_members_names><![CDATA[Goran Durn, Sonja Lojen, Mladen  Juračić, Sibila Borojević Šoštarić, Marta Mileusnić, Neda Vdović, Srečo Davor Škapin, Uroš Barudžija, Irena Jurina Tokić, Maja Ivanić, Stanko Ružičić, Igor Felja, Tomislav Brenko, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[geochemistry, nanoparticles, nanominerals, sediments, soils ]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[The Project aims to investigate mineralogical, morphological, geochemical and surface physico-chemical properties of the naturally occurring inorganic nanomineral fraction separated from different modern marine and lacustrine sediments and soils developed on carbonate rocks along the Adriatic coast. The unique structural, chemical and surface properties of nanomineral phases and their role in cycling of trace elements in modern sediments and soils will be determined. The primary objectives of this project are: (1) to identify the size, the unique mineralogical, morphological, geochemical and surface physico-chemical properties of the naturally occurring inorganic nanomineral fractions; (2) to determine the early diagenetically driven formation and phase transformation of nanosized carbonate, sulfide and iron (hydr)oxide particles in modern lacustrine and marine sediments at the nanoscale; (3) to resolve pedogenetically driven formation of nanosized clay mineral and iron and manganese (hydr)oxide particles in soils at the nanoscale. Specifically, the role of iron (hydr)oxides, and humic materials on nanoscale agglomeration processes in soils will be also evaluated; (4) to determine the carbonate equilibrium, the origin of bulk and molecularly uncharacterized sedimentary organic matter, as well as dissolved inorganic matter in the sediments, soils and interstitial water using stable isotopes (13C/12C and 15N/14N) as natural tracers. Sources of DIC (carbonate dissolution vs. decomposition of sedimentary organic matter) in the pore water and in the DIC flux across the sediment – water interface, as well as in the sedimentary carbonate fraction will be appointed, so as to estimate the contribution of organically derived CO2 to the formation of authigenic nanocarbonate solids; and (5) to introduce and incorporate findings from “NanoMin” into the Croatian geosciences domain.]]></summary_en></project><project>
<id>2247</id><title_hr><![CDATA[Inženjering kristalnih materijala pomoću metalnih kompleksa i nekovalentnih interakcija]]></title_hr><title_en><![CDATA[Engineering crystalline materials using metal complexes and non-covalent interactions]]></title_en><user_id>1229</user_id><user_firstLast_name>Marijana Đaković</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2013-11</proposal_call><code>UIP-2013-11-1809</code><acronim><![CDATA[CRYSTIN]]></acronim><duration>01.09.2014 - 20.11.2017</duration><status>Završio</status><financ_value>91.939,15 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, </scie_field_hr><scie_field_en>Chemistry, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>713, 2648, 1327, 4669, 3881, 17739, </team_members_id><team_members_names><![CDATA[Željka Soldin, Aleksandar Višnjevac, Boris-Marko Kukovec, Ivan Kodrin, Christer Aakeroy, Mladen Borovina, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[crystal engineering, non-covalent interactions, supramolecular architecture, synthons, metal complexes]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Interdisciplinary research at the interface of chemistry and materials science has been remarkably successful at producing technologies that have revolutionized all aspects of everyday life.  However, there is still a great need for new solids with ‘improved’ physical properties (faster, cheaper, smarter or more responsive than current alternatives). Unfortunately, the ability to ‘dial-in’ a property or physical response remains a major challenge. Therefore, our goal is to establish reliable avenues for the design of crystalline metal-containing materials by encoding building-blocks with structural-preferences that lead to ‘programmable’ assembly, thus avoiding serendipity and chance when targeting new materials with specific and tunable properties. To achieve this, we first need to map out the structural landscape that controls how metal complexes communicate and subsequently assemble into 3-D architectures.We will explore and quantify the interrelationship between ligand-field splitting energy, coordination geometry, metal-ligand dimensionality, ligand flexibility, and supramolecular assembly, one variable at a time, using a combination of experiment and theory.  This will enable us to map out the structural landscape defined by metal(II) complexes (Co, Ni, Cu and Cd) and custom-made ligands decorated with functionalities that are known to form reliable supramolecular synthons in organic solids.New structural and spectroscopic information will be complemented by data obtained by mining the CSD, while computational methods will inform both the planning as well as the interpretation of the experimental efforts. The results obtained in this systematic and multidisciplinary research program will create new avenues towards the design of crystalline metal-containing materials based on reliable structure-activity protocols.]]></summary_en></project><project>
<id>2249</id><title_hr><![CDATA[Razvoj paketa računalskih programa za naprednu analizu štitova od gama i neutronskog zračenja]]></title_hr><title_en><![CDATA[Development of Code Package for Advanced Gamma and Neutron Shielding Analysis]]></title_en><user_id>6070</user_id><user_firstLast_name>Krešimir Trontl</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2013-11</proposal_call><code>UIP-2013-11-3522</code><acronim><![CDATA[DOCPAGANSA]]></acronim><duration>21.07.2014 - 20.10.2017</duration><status>Prekinut</status><financ_value>53.487,29 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Elektrotehnika, </scie_field_hr><scie_field_en>Electrical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id>7255, 6980, 6827, 17764, </team_members_id><team_members_names><![CDATA[Dubravko Pevec, Radomir Ječmenica, Mario Matijević, Paulina Dučkić, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[machine learning, active learning, parallel and distributed computing, gamma shielding, neutron shielding]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Radiological safety analysis is equally important in all fields of peaceful application of nuclear energy, like industry or medicine, as well as for adequate radioactive waste management. In general, shielding analyses can be classified into two categories: preliminary analyses and final analyses. Preliminary analysis can be conducted using computer codes based on engineering methods, the most used one based on point-kernel method. Recent research indicated that a new approach can be used in determination of buildup factors as the key parameters of point-kernel method. The approach is based on machine learning technique, namely Support Vector Regression (SVR). For efficient training of the SVR models of a complex physical problem, an active learning procedure has to be defined. Final shielding analysis is usually conducted by computer codes based on either deterministic or statistic methods placing high time and hardware demands, but resulting in more accurate results. Advanced numerical procedures utilize advantages of both, deterministic approach as well as stochastic approach resulting in a hybrid deterministic-stochastic procedure increasing the efficiency of the overall analysis.The overall objective of the proposed project is the development of the synthesized calculational tool to enable all stages of a shield design to be performed within integrated environment. To accomplish this objective following activities are planned: definition of the optimal active learning procedure in regression framework to prepare data sets for SVR model creation, investigation of gamma and neutron buildup factors and preparation of SVR models, development of the computational tool for preliminary stage shielding design, optimization of hybrid deterministic-stochastic numerical procedure, development of the control module for automatic shielding analyses process control, preparation of front-end and back-end interface, testing of the final shielding analysis environment. ]]></summary_en></project><project>
<id>2255</id><title_hr><![CDATA[Biofizikalni dizajn antimikrobnih peptida i inovativni molekularni deskriptori]]></title_hr><title_en><![CDATA[Biophysical Design of Antimicrobial peptides and Innovative Molecular Descriptors]]></title_en><user_id>5542</user_id><user_firstLast_name>Damir Vukičević</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2013-11</proposal_call><code>IP-2013-11-8481</code><acronim><![CDATA[BioAmpMode]]></acronim><duration>15.09.2014 - 14.12.2017</duration><status>Završio</status><financ_value>50.800,20 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Biologija, </scie_field_hr><scie_field_en>Biology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Splitu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Split, Faculty of Science]]></institution_en><team_members_id>3581, 3589, 3599, 87, 4882, 5478, 5373, 5545, 5636, 6123, 6627, 6630, 6633, 6683, 5731, 18995, 17844, 586, 3580, </team_members_id><team_members_names><![CDATA[Juraj Simunić, Nada Ilić, Mario Novkovic, Goran Gajski, Frances Separovic, Alessandro Tossi, Anita Kriško, Jelena Sedlar, Tomislav Došlić, Marija Raguž, Nataša  Vučemilović-Alagić, Mara Kozić, Lara Romac, Lucija Krce, Ana Maravić, Luka Gujinović, Tomislav Rončević, Ivana Goić Barišić, Davor Juretic, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[Antimicrobial peptides, Molecular descriptors, Therapeutic index, Drug development, Design, Data-mining, Antibiotics, Multidrug resistance]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[The starting point of this interdisciplinary project is bioinformatic and chemoinformatic data collection connecting molecular structure with physico-chemical and biological properties. In the case of antimicrobial peptides, measured biological activity and therapeutic index data will be collected from published papers with the goal of constructing robust and accurate predictive models. A large amount of data regarding the 20 natural amino acids attributes will also be collected and analysed. We plan to propose new scales of amino-acid attributes that may be a basis for a multitude of future studies. In our experience, construction of good predictive models is not possible without using biophysical insights to propose appropriate molecular descriptors crucial for data-mining procedure and model building. These models should be based on newly developed molecular descriptors. Study of molecular descriptors will be important part of this project, their extremal properties (as indicators of the most active compounds), their complexity of calculation (since exhaustive search for optimal compounds can be computationally demanding) and their interrelationships. Dedicated algorithms for in-silico identification or proposal of structures with the desired properties will be built and verified through synthesis, characterization and testing of predicted antimicrobials. The activity, selectivity, conformation and mechanism of action of lead compounds will be explored using biophysical, biochemical and microbiological techniques. Preliminary investigations by our group of graduate, doctoral and postdoctoral biophysics students has already led to the identification of two designed peptides as being very active against pan-resistant Acetinobacter baumanni, so that initial drug development is within the scope of this project with the aim of finding new classes of non-toxic peptide antibiotics active against multidrug resistant bacteria.]]></summary_en></project><project>
<id>2258</id><title_hr><![CDATA[Karakterizacija reakcije osteoklastnih progenitora na artritis]]></title_hr><title_en><![CDATA[Characterization of osteoclast progenitor responses to arthritis]]></title_en><user_id>3075</user_id><user_firstLast_name>Danka Grčević</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2013-11</proposal_call><code>IP-2013-11-5699</code><acronim><![CDATA[COPERA]]></acronim><duration>01.09.2014 - 31.08.2017</duration><status>Završio</status><financ_value>92.817,94 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb School of Medicine]]></institution_en><team_members_id>3895, 4356, 2978, 3882, 3832, 3604, 5107, 5106, 5878, 5110, 5860, 17836, </team_members_id><team_members_names><![CDATA[Alan Šućur, Frane Paić, Vedran Katavić, Nataša Kovačić, Elvira Lazić Mosler, Marina Ikić Matijašević, Zrinka Jajić, Asja Stipić Marković, Peter Ian Croucher, Ivo Kalajzić, Hector Leonardo Aguila, Darja Flegar, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[osteoclasts, arthritis, inflammation, progenitors, differentiation, cytokines, chemokines]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Chronic joint diseases affect more than a third of the world’s population and represent a major health problem. Several forms are classified in clinical practice, depending on the main pathogenic mechanism: osteoarthritis, rheumatoid arthritis (RA) and spondyloarthritis Collagen-induced arthritis (CIA) is a widely used mouse model of RA and is still an indispensible tool to study the disease pathogenesis. Through the production of osteoresorptive mediators by immune cells, chronic inflammation in arthritis creates a microenvironment that promotes osteoresorption by osteoclasts (OC). OCs are multinucleated bone-resorbing cells arising from myeloid hematopoietic lineage. A number of systemic and local stimuli, such as hormones and cytokines/chemokines, promote osteoclastogenesis by enhancing OC differentiation, migration, activation, lifespan and function, but the exact mechanisms of how the inflammatory network works in vivo in the context of arthritis are largely unclear. Particularly, the human osteoclast progenitor (OCP) populations are not precisely defined and it is, as yet, unknown which critical mediators have the potential to activate OCPs and attract them to produce joint lesions. Using the mouse model of CIA and samples from arthritic patients we propose to elucidate differentiation sequence of early progenitors into mature OCs, shifts in the frequency of discrete OCP subpopulations and their migration patterns during arthritis. We plan to identify distinct OCP subpopulations in the bone marrow, periphery and joint lesions, their migratory and homing patterns, and their functional links to bone loss in arthritis. We expect to define the properties of inflammatory microenvironment in the regulation of OC trafficking, differentiation and activity in arthritis. A better characterization of arthritis-induced OCP subpopulations could offer the potential to design therapeutic approaches to control their migration and curtail their osteoresorptive potential.]]></summary_en></project><project>
<id>2259</id><title_hr><![CDATA[Molekularni mehanizmi imunološkog djelovanja PVR(CD155) u virusnoj i tumorskoj patogenezi]]></title_hr><title_en><![CDATA[Molecular mechanisms of PVR(CD155) immunological pathways in viral and tumor pathogenesis]]></title_en><user_id>4941</user_id><user_firstLast_name>Tihana Lenac Roviš</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2013-11</proposal_call><code>UIP-2013-11-1533</code><acronim><![CDATA[PVRreg]]></acronim><duration>31.10.2014 - 30.04.2018</duration><status>Završio</status><financ_value>131.726,72 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo, Prirodne znanosti, </scie_area_hr><scie_area_en>Biomedicine and health sciences, Natural sciences, </scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Medicine]]></institution_en><team_members_id>5361, 5312, 5204, 22539, </team_members_id><team_members_names><![CDATA[Hrvoje Šimić, Antonija Miletić, Paola Kučan, Ivana Stražić Geljić, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[poliovirus receptor, PVR, CD155, cytomegalovirus, CMV, immunoevasion, tumor]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[The project is focused on the role of PVR (poliovirus receptor) which serves as a ligand for both inhibitory (TIGIT) and activating (DNAM-1 and Tactile) receptors. The evidence has been accumulated indicating the role of PVR and its receptors in immune surveillance including the control of viral infections, tumors, as well as in pathogenesis of autoimmune diseases. Of note is that PVR is constitutively expressed on the majority of somatic cells, while its receptors are expressed on the majority of lymphocyte population. In many respects the interaction of PVR with its paired set of inhibitory and activating receptors resemble the interaction of paired co-stimulatory immune cell receptors and their cellular ligands (B7/CD28/CTLA-4). These co-stimulatory molecules have been the subject of intensive studies that resulted in immunoregulatory pharmaceutical agents for use in humans. The studies proposed here are based on the finding that human cytomegalovirus (HCMV) affects the surface expression of PVR (Nat Immunol. 2005) and on our preliminary results indicating that mouse cytomegalovirus (MCMV) also downregulates mouse PVR. Thus, we first focused on the identification of MCMV gene(s) (proteins) involved in the PVR regulation, but also on the consequence of this viral regulation on antiviral immune response in vivo. To that aim we will generate MCMV mutants lacking viral regulators and test their in vivo susceptibility to components of innate and acquired immune response. We expect that the results obtained will further broaden the knowledge of PVR regulation and its significance in immune control, which will eventually help to translate this knowledge to developing new immunotherapeutic tools. Namely, one aim of this project is to engineer antibody specific for human PVR in order to be used as a tool in targeted tumor therapy. This idea is based on the fact that many tumors over-express PVR, which could be used in antibody mediated uptake of anti-tumor compounds. ]]></summary_en></project><project>
<id>2260</id><title_hr><![CDATA[Moderne i suvremene umjetničke mreže, umjetničke grupe i udruženja: Organizacijski i komunikacijski modeli suradničkih umjetničkih praksi 20. i 21. stoljeća]]></title_hr><title_en><![CDATA[Modern and Contemporary Artist Networks, Art Groups and Art Associations: Organisation and Communication Models of Artist Collaborative Practices in the 20th and 21st Century]]></title_en><user_id>6142</user_id><user_firstLast_name>Ljiljana Kolešnik</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2013-11</proposal_call><code>IP-2013-11-6270</code><acronim><![CDATA[ARTNET]]></acronim><duration>01.09.2014 - 10.12.2018</duration><status>Završio</status><financ_value>71.311,70 eur</financ_value><scie_area_hr>Humanističke znanosti, Društvene znanosti, Tehničke znanosti, </scie_area_hr><scie_area_en>Humanities, Social sciences, Technological sciences, </scie_area_en><scie_field_hr>Povijest umjetnosti, </scie_field_hr><scie_field_en>Art history, </scie_field_en><institution_hr><![CDATA[Institut za povijest umjetnosti]]></institution_hr><institution_en><![CDATA[Institute of Art History, Zagreb]]></institution_en><team_members_id>2535, 6333, 5489, 4944, 4649, 6030, 4910, 21394, 17659, 23291, </team_members_id><team_members_names><![CDATA[Petar Prelog, Sanja ¸Horvatinčić, Dalibor Prančević, Željka Tonković, Tamara  Bjažić Klarin, Ivana Meštrov, Irena Kraševac, Sanja Sekelj, Nikola Bojić, Artur Šilić, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[history of art, methodology, artist networks, art groups, social networks, data visualization, Croatian modern art, Croatian contemporary art]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Research topics of this project are the organization and communication models embedded into artist networking and artist collaborative practices of the 20th and 21st century, as they are manifested in the Croatian art of that period. Project initial hypothesis is that artist networks, art groups and art associations form the most important platform of cultural exchange in modern and contemporary visual arts due to the similarity of underlying organization and communication models regardless of geo-cultural location at which they appear. A degree of their diversity in art practice of particular local community at particular historical moment is proportional to the dynamics and volume of its participation in the international/cross-cultural exchange. To prove our hypothesis and identify, describe and explain these organization and communication models as generally applicable – which is the main objective of the project - we shall investigate Croatian artist networking and collaborative practices on the background of similar phenomena in other European countries and with regard to poetic requirements of different periods in modern and contemporary art, conventions of social interactions and available techniques/technologies of communication. As the methodology of art history does not meet the complexity of the research topic, we shall develop interdisciplinary methodological apparatus combining knowledge and analytic tools of art history, sociology and information science. Considerable amount of data collected through the extensive infield research will be stored in Croatian Artists Networks Information System developed in the course of the project and supporting network visualization techniques as a cognitive research tool for experimental presentation of our research results framed with the appropriate structural narratives (textual, visual, GIS data). Project results will be also presented in 2 books, 7 articles and at the closing international conference.]]></summary_en></project><project>
<id>2264</id><title_hr><![CDATA[Nastavničke emocije i strategije emocionalne regulacije: osobni i kontekstualni antecedenti i efekti na motivaciju, dobrobit i odnose sa studentima]]></title_hr><title_en><![CDATA[Teachers’ emotions and emotion regulation strategies: personal and contextual antecedents and effects on motivation, well-being and relationships with students]]></title_en><user_id>6118</user_id><user_firstLast_name>Irena Burić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2013-11</proposal_call><code>UIP-2013-11-5065</code><acronim><![CDATA[TEERS-ZD5]]></acronim><duration>01.09.2014 - 31.08.2017</duration><status>Završio</status><financ_value>26.534,50 eur</financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Psihologija, </scie_field_hr><scie_field_en>Psychology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zadru]]></institution_hr><institution_en><![CDATA[University of Zadar]]></institution_en><team_members_id>6241, 5908, 6136, 6552, 21148, </team_members_id><team_members_names><![CDATA[Izabela Sorić, Zvjezdan Penezić, Ana Slišković, Ivana Macuka, Enrica Ciucci, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[Teachers, emotion, emotion regulation strategies, personal antecedents, contextual antecedents, motivation, well-being, relationship with students]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Although cognition, motivation and emotion are recognized by psychologists as the three fundamental classes of mental operations (Mayer, Salovey and Caruso, 2000), most research in educational psychology has primarily focused on the first two classes. This is especially true regarding teachers’ emotional lives. The existing knowledge on teachers’ emotions indicates their influential potential on instructional practices, professional and personality development and well-being. By implication, emotions experienced by teachers in classroom settings and in relation to their professional activities, arise as a very important topic of research. Thus the main goal of this research proposal is to investigate the phenomena of teachers’ emotions and emotion regulation strategies as well as their personal and contextual antecedents and effects on various aspects of personal and professional functioning. In order to achieve this goal, the multimethod approaches will be implemented.  More precisely, through the combination of qualitative and quantitative  methods, cross-sectional and longitudinal research designs, and individual and nomothetic approach, relations between teachers’ emotions and emotion regulation strategies, their personal (e.g. temperament, personality, beliefs, goals, cognitive appraisals) and contextual antecedents (factors from teachers’ school environment), as well as their effects on motivation (e.g. intrinsic vs. extrinsic motivation, goal orientations, self-efficacy), well-being (e.g. emotional labour, emotional exhaustion, burnout, mental health and intention to leave the profession) and relationships with students (e.g. different aspects of student-teacher interaction) will be explored on the samples of elementary-school teachers. ]]></summary_en></project><project>
<id>2267</id><title_hr><![CDATA[Profesionalni razvoj tijekom adolescencije: Razvoj i provjera Modela tranzicije karijere u adolescenciji]]></title_hr><title_en><![CDATA[Vocational Development in Adolescence: Setting the Adolescent Career Transition Model]]></title_en><user_id>1178</user_id><user_firstLast_name>Iva Šverko</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2013-11</proposal_call><code>UIP-2013-11-1229</code><acronim><![CDATA[VDAACTM]]></acronim><duration>01.07.2014 - 30.06.2017</duration><status>Završio</status><financ_value>38.945,46 eur</financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Psihologija, </scie_field_hr><scie_field_en>Psychology, </scie_field_en><institution_hr><![CDATA[Institut društvenih znanosti Ivo Pilar]]></institution_hr><institution_en><![CDATA[Institute of Social Sciences Ivo Pilar in Zagreb]]></institution_en><team_members_id>6293, 6545, </team_members_id><team_members_names><![CDATA[Toni Babarović, Vanja Međugorac, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[career transition, adolescence, career maturity, career identity, career decision making]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[The aim of this project is to develop, postulate and evaluate an Adolescent Career Transition Model (ACTM). For most people the adolescence is the tipping point for career decision making. Last grade high-school students have to decide between further education on universities or entering the world of work and finding a job. To successfully overcome this important career transition period, adolescents have to become aware of their preferences and capabilities, to crystallize their career goals and to form their vocational identity. By implementing their vocational identity through engagement in their desired job or educational program, they should be able to achieve success and satisfactions in their careers, to fit in and adjust to their working environment and job demands, and to be motivated for their work and future advancement. The Adolescent Career Transition Model encompasses several career related behaviours, competences and traits that can influence positive career transition outcomes. We will assess approximately 1200 high school students at the beginning of the last grade of high-school (17-18 years) and follow their career development for the next 18 months. In three separate time points we will administer measures of career-related traits and social support, career self-guidance competencies, vocational development and career transition outcomes, through a secure online testing system that will be developed for this project. Statistical data analysis of the obtained data will be performed by adequate multivariate models to answer specific research objectives. Once the postulation and evaluation of the ACTM and the dissemination of the results are completed, the aim of the project is to create a new online career guidance system on the basis of the results of our research. This new online guidance system will be open and free for public use, and remain as a valuable and practically usefully legacy of the project.]]></summary_en></project><project>
<id>2273</id><title_hr><![CDATA[Sveobuhvatni model istraživanja zabrinutosti za privatnost u online okruženju]]></title_hr><title_en><![CDATA[Extended model of online privacy concern ]]></title_en><user_id>177</user_id><user_firstLast_name>Jelena Budak</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2013-11</proposal_call><code>IP-2013-11-7913</code><acronim><![CDATA[PRICON]]></acronim><duration>01.07.2014 - 30.06.2018</duration><status>Završio</status><financ_value>66.070,32 eur</financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Ekonomija, </scie_field_hr><scie_field_en>Economy, </scie_field_en><institution_hr><![CDATA[Ekonomski institut Zagreb]]></institution_hr><institution_en><![CDATA[Institute of Economics in Zagreb]]></institution_en><team_members_id>189, 174, 3437, 674, 17736, </team_members_id><team_members_names><![CDATA[Ivan-Damir   Anić, Edo Rajh, Vatroslav Škare, Bruno Škrinjarić, Vedran Recher, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[online privacy concern, antecedents, internet, consumer protection, survey]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[The research project will develop a comprehensive integrated model of privacy concern in the online environment and empirically test it in order to provide deeper understanding of various interactions between antecedents, concerns and consequences of online privacy. The research objectives will be achieved initially by identifying and developing (i) a comprehensive list of antecedents such as demographic factors (e.g. gender, education), experience factors (e.g. internet use experience, web expertise) and social-psychological factors (values, attitudes), and (ii) a comprehensive list of consequences of online privacy concern on individual-user level. These inputs will be used to develop an extended integrated model of online privacy concern in order to examine conceptual interrelations. Upon building a model, a customized survey questionnaire will be designed and measurement instruments for variables tested. The field research will consist of surveying 2,000 citizens in Croatia to assess their attitudes and behavior patterns when taking different roles and actions in the online environment. This core part of the research aims to empirically test the conceptualized model by employing adequate analytical tools to the large database collected in the survey. The research will result in the final definition of integrated theoretical framework of online privacy concern that will consolidate various streams of research in this field. The extended model of online privacy concern could be applied in future development in the related domain. The additional project outcomes are policy implications and recommendations for regulatory control, internet users policy and business strategies.]]></summary_en></project><project>
<id>2277</id><title_hr><![CDATA[Poluvodički elementi visokih performansi  za primjene u sklopovima za bežične komunikacije i optičke detektore]]></title_hr><title_en><![CDATA[High-performance Semiconductor Devices for Wireless Circuit and Optical Detection Applications]]></title_en><user_id>6955</user_id><user_firstLast_name>Tomislav Suligoj</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2013-11</proposal_call><code>IP-2013-11-9006</code><acronim><![CDATA[HiPerSemi]]></acronim><duration>25.08.2014 - 24.08.2018</duration><status>Završio</status><financ_value>119.848,70 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Elektrotehnika, </scie_field_hr><scie_field_en>Electrical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id>7054, 5077, 6083, 6081, 7123, 7148, 7085, 17830, 6852, </team_members_id><team_members_names><![CDATA[Mirko Poljak, Sanja Žonja, Tihomir Knežević, Josip Žilak, Igor Krois, Dubravko Babic, Boris Sviličić, Sabina Krivec, Marko Koričić, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[semicoductors, microelectronics, bipolar transistors, photodetectors, photodiodes, CMOS, modeling, MOSFET, RF circuits]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[The objective of this project is to provide notable scientific contributions by designing and utilizing the advanced semiconductor devices for the wireless communication circuits and solid-state optical detection applications. Research in this project will be grouped in three major activities, which are: (i) Horizontal Current Bipolar Transistor (HCBT) for RF Wireless Circuits, (ii) Characterization and applications of solid-state photodetectors, and (iii) Modelling of MOS, photodetector and other advanced electron devices. The novel wireless RF communication circuits such as mixer, frequency divider, voltage-controlled oscillator, RF switch and power amplifier will be designed and fabricated in HCBT technology as the first such circuits using the HCBT as an active component. The measurements of noise, reliability and on-wafer uniformity as well as linearity, gain and efficiency will be performed on transistors and circuits. The characterization of material properties of pure amorphous boron (PureB) layers will be made in order to determine the composition, electrical and optical properties of the layer and to develop the model of charge carrier transport through it. They will be correlated with electrical measurements to find out currently-unknown physical mechanisms responsible for the current reduction and for the record-high performance of photodides with PureB layers. The investigation of the novel materials such as Ge, SiGe and GaN for ultra-scaled advanced CMOS structures, i.e. FinFETs, will be performed by the development of novel models and simulation environment. The analog/RF parameters and characteristics will be extracted for FinFETs with different geometries and materials in order to determine the optimum structure for future RF systems.]]></summary_en></project><project>
<id>2281</id><title_hr><![CDATA[Metode deidentifikacije za meke i ne-biometrijske identifikatore]]></title_hr><title_en><![CDATA[De-identification Methods for Soft and Non-Biometric Identifiers]]></title_en><user_id>6974</user_id><user_firstLast_name>Tomislav Hrkać</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2013-11</proposal_call><code>UIP-2013-11-1544</code><acronim><![CDATA[DeMSI]]></acronim><duration>01.09.2014 - 31.08.2017</duration><status>Završio</status><financ_value>68.410,64 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Računarstvo, </scie_field_hr><scie_field_en>Computer sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id>4290, 6564, 6814, 4584, 6563, </team_members_id><team_members_names><![CDATA[Slobodan Ribarić, Zoran Kalafatić, Karla Brkić, Darijan Marčetić, Ivan Filković, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[De-Identification, Privacy Protection, Image Processing, Video Processing, Biometrics, Multimedia]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Advances in audio and video recording devices, web technology and signal processing have highly facilitated the efficacy of audio and video acquisition. This capability is now widely exploited in a variety of scenarios to obtain audio-video recordings of people, raising serious privacy concerns. The protection of sensitive private data is required by EU’s Data Protection Directive (95/46/EC). De-identification in multimedia content can be defined as the process of concealing identities of individuals captured in a given set of data, for the purpose of protecting their privacy. Soft biometric and non-biometric characteristics such as tattoos, birthmarks, scars or dressing style also carry potentially identity-revealing information and have to be dealt with in the process of de-identification. This is an interdisciplinary challenge, involving such scientific areas as image processing, video tracking and biometrics. This project proposal aims to development of novel and robust methods for de-identification of soft and non-biometric identifiers in videos and images.]]></summary_en></project><project>
<id>2283</id><title_hr><![CDATA[Arheološka istraživanja kasnog Pleistocena i ranog Holocena u Limskom kanalu, Istra ]]></title_hr><title_en><![CDATA[Archaeological investigations into the Late Pleistocene and Early Holocene of the Lim Channel, Istria]]></title_en><user_id>2764</user_id><user_firstLast_name>Ivor Janković</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2013-11</proposal_call><code>UIP-2013-11-7789</code><acronim><![CDATA[ARCHAEOLIM]]></acronim><duration>15.06.2014 - 14.06.2017</duration><status>Završio</status><financ_value>79.368,24 eur</financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Arheologija, </scie_field_hr><scie_field_en>Archeology, </scie_field_en><institution_hr><![CDATA[Institut za antropologiju]]></institution_hr><institution_en><![CDATA[Institute for Anthropological Research]]></institution_en><team_members_id>3839, 3871, 6897, 4112, 3711, 3440, 4229, 6754, 2993, 21180, </team_members_id><team_members_names><![CDATA[James Ahern, Fred  Smith, Darko Komšo, Sanjin Mihelić, Jacobo Weinstock, Katarina Gerometta, Rory Becker, Krunoslav  Zubčić, Barbara Cvitkušić, Antonela Barbir, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[Paleolithic, Mesolithic, Neandertals, archaeology, caves, Croatia, prehistory, Pleistocene, Holocene ]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[The proposed project is aimed at archaeological research of four cave sites in the Lim Channel, Istria, where previous small-scale excavations and field survey documented human habitation during the Late Pleistocene and Early Holocene. It is expected that this work will provide data for understanding a number of important issues regarding behavioral and possibly biological aspects of human groups during a time when Late Glacial hunter gatherers were forced to change and adapt to a changing environmental and other pressures. Presence of Mousterian artefacts at one of the sites, and Upper Paleolithic tool types at another suggests two populations (i.e. Neandertals and anatomically modern humans) were present in the region during the Late Pleistocene. Data from the proposed excavations may provide a basis to test some of the highly debated questions regarding the relation of biological population to behavioral aspects (e.g. whether Neandertals or anatomically modern humans were responsible for Early Upper Paleolithic, is there a sharp distinction in behavior and anatomy between these groups etc. Furthermore, at one site early Mesolithic is documented, while at another Late Mesolithic is present, allowing similar issues regarding behavior and other aspects to be tested, including issues related to the transition to Neolithic (agricultural) lifestyle. A comparison of data between all four sites could provide us with a basis for testing of issues related to changing life ways, land use, movement patterns, site use, biological aspects (similarities and differences), contact zones, mobility, continuity, etc. at times of changing climatic and environmental conditions and thus help us to understand this crucial time period, in particular, and how humans respond to such changes, in general. Results from the project will also provide a basis for development of archaeology–based tourism and thus directly benefit the local community and Croatian economy in the long run.]]></summary_en></project><project>
<id>2284</id><title_hr><![CDATA[Unaprijeđeno istraživanje općekorisnih funkcija šuma]]></title_hr><title_en><![CDATA[Advanced Forest Environmental Services Assessment]]></title_en><user_id>7009</user_id><user_firstLast_name>Ivan Pilaš</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2013-11</proposal_call><code>IP-2013-11-1924</code><acronim><![CDATA[AFORENSA]]></acronim><duration>01.07.2014 - 30.06.2018</duration><status>Završio</status><financ_value>111.752,60 eur</financ_value><scie_area_hr>Biotehničke znanosti, Tehničke znanosti, </scie_area_hr><scie_area_en>Biotechnical sciences, Technological sciences, </scie_area_en><scie_field_hr>Biotehnologija, </scie_field_hr><scie_field_en>Biotechnology, </scie_field_en><institution_hr><![CDATA[Hrvatski šumarski institut]]></institution_hr><institution_en><![CDATA[Croatian Forest Research Institute]]></institution_en><team_members_id>3207, 3290, 7002, 3272, 5644, 5659, 5655, 17863, 3478, </team_members_id><team_members_names><![CDATA[Damir Medak, Ivan Medved, Dražen Odobašić, Ela Vela Bagić, Jasnica Medak, SANJA PERIĆ, MARTINA TIJARDOVIĆ, Luka Rumora, Mario Miler, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[Forest environmental services, Remote sensing, Ecohydrology, Biodiversity, GIS, Climate change ]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[The main objective of AFORENSA is to generate relevant knowledge how the forest ecosystems in Croatia responds to observed extreme climatic variations, and what are possible future expectations in respect to the progression of climate change and disturbances of natural hydrologic cycle with intensification of drought frequency and severity. This objective is aimed to be resolved by implementing of the novel forest ecosystem assessment approach, applicable for the country scale, which incorporates: a) traditional in situ ecosystem survey (soil and vegetation), b) analysis of the functional state of the ecosystems by remote sensing, c) downscaling of the regional climatic models and d) coupling of scenario outputs with ecohydrological models on a site specific environmental settings. The core system on which AFORENSA activities will be build up, presents “Dynamical Geoinformation system of forest ecosystems in Croatia” (DYN-CROFOR), a technological project financed by the Ministry of Science and Education from 2003 to 2007. Aforensa is aiming at the inventory, and integration of terrestrial forest ecosystem research on the Web-Gis (DYN-CROFOR) platform incorporating automatized procedures for retrieving remote sensing data (such as MODIS and MERIS vegetation indices)  and with the  addition of incorporating Data mining procedures and the full power of R, a language and environment for statistical computing and graphics. Project workflow consists of four, interrelated, work packages: a) INVENTORY, b) AUTOMATIZATION, c) MINING, d) UPGRADING. AFORENSA will contribute with speeding-up of future exploratory forest ecosystem research, and with its capability of near real time data processing will present a basis for the development of “Forest watch”; an observatory for early determination of potentially harmful effects of Climate Change on forest ecosystem services such as biodiversity and water.]]></summary_en></project><project>
<id>2291</id><title_hr><![CDATA[Tekstualne mreže ranonovovjekovne Hrvatske]]></title_hr><title_en><![CDATA[Textual networks of early modern Croatia]]></title_en><user_id>2952</user_id><user_firstLast_name>Lahorka Plejić Poje</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2013-11</proposal_call><code>IP-2013-11-4785</code><acronim><![CDATA[TeMrežaH]]></acronim><duration>15.11.2014 - 15.11.2018</duration><status>Završio</status><financ_value>47.375,41 eur</financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Filologija, </scie_field_hr><scie_field_en>Philology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu]]></institution_hr><institution_en><![CDATA[University of Zagreb]]></institution_en><team_members_id>1416, 5337, 3921, 4025, 4310, 5006, 5066, 5024, 4860, 3931, 6715, 7050, 4221, 7251, 7383, </team_members_id><team_members_names><![CDATA[Neven Jovanović, Irena Bratičević, Tomislav Bogdan, Tamara Tvrtković, Violeta Moretti, Francesca Maria Gabrielli, Dolores Grmača, Bratislav Lučin, Šime Demo, Gorana Stepanić, Dunja Fališevac, Vladimir Rezar, Jasmina Lukec, Darko Novaković, Luka Špoljarić, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[scholarly edition, early modern Croatian literature, digital humanities, Renaissance, Baroque, 18th century]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[We propose to establish a collaborative framework for scholarly editions of Croatian early modern written heritage, regardless of its linguistic medium (Croatian, Latin, Italian, German) and its material manifestation (manuscripts, printed books, digital texts). A significant part of this heritage is still not easily or reliably accessible to modern scholarship. Leveraging current European and international achievements and initiatives, our project will solve textual and editorial problems through scholarly collaboration, in that way providing grounds and opportunity for further interpretative insights about the life of the texts. The project will prepare and publish both printed and digital editions; editorial work of team members will be submitted to early collective peer review and discussion. The proposed framework will also serve as a training ground for next generations of textual scholars studying early modern Croatian literature; researchers of all career stages (including undergraduate, graduate, and PhD students) will be offered an opportunity to make their first contributions, also peer-reviewed and carefully attributed. Through these innovative procedures we aim to reinterpret scholarly edition as a fruitful and exciting interpretative undertaking, without which there can be no real understanding of our intellectual history. The main outcome of our project will be 15 scholarly editions published over four years: six texts of Croatian authors in Croatian (Mršić, Primović, Palmotić Dionorić, Divković, the Kajkavian miscellany of Nikola Šafran, M. Zlatarić), an edition of three Croatian woman writers in Italian (G. and S. Bona, M. Gondola Gozze), and eight texts of Croatian authors in Latin (Nikola Modruški, Marulić, Beneša, V. Gučetić, Ritter Vitezović, Tomko Mrnavić, M. Zlatarić, the Macaronica Croatica).]]></summary_en></project><project>
<id>2299</id><title_hr><![CDATA[Evlija Čelebi i Hrvati, nove perspektive]]></title_hr><title_en><![CDATA[Evliya Chelebi and Croats, new perspectives]]></title_en><user_id>98</user_id><user_firstLast_name>Nenad Moačanin</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2013-11</proposal_call><code>IP-2013-11-9215</code><acronim><![CDATA[EvliyaChelebi]]></acronim><duration>01.08.2014 - 30.11.2017</duration><status>Završio</status><financ_value>59.725,26 eur</financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Povijest, </scie_field_hr><scie_field_en>History, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Filozofski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Humanities and Social Sciences]]></institution_en><team_members_id>6011, 6728, 6807, 7081, </team_members_id><team_members_names><![CDATA[Kornelija Jurin Starčević, Vjeran Kursar, Ekrem Čaušević, marta andrić, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[Evliya Chelebi, Travelouge, Croatia, History, Language, Critical Edition, Ottoman Studies]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Thirty years ago the autograph of the Evliya Chelebi&#39;s travelogue (SeyahatnameorBook of travels) was found. Evliya Chelebi is the most famous Ottoman traveller and writer and the worldwide cited Ottoman author. His Seyahatname in Ottoman was recently  published in Istanbul in ten volumes. For Croatian history the volumes V, VI and partly VII have the paramount significence.A critical edition and translation of the autograph’ssections of the books V, VI and VII into Croatian language does not exist. HazimŠabanović made translation on the basis of a printed version from 1900 which was done upon an inaccurate, even censored copy. The translator himself had shortened the narrative in many places. Even a brief insight in original text shows dramatical differences and alterations in quantity of text (there is up to 35 percent more text in  the autograph)  and quality of  informations (substantially new informations, thoroughly different from those in Šabanović&#39;s translation). The aim of the project is to investigate this „missing link“ among the narrative sources for Croatian history in Early Modern Period, i.e. to scrutinize the autograph, to translate parts of the V, VI and VII book with commentaries and footnotes, and to produce supporting articles. A picture of Croatian societies in different political frames which is given in the Seyahatname has never been a subject of scholarly research. This would lead toward the comprehensive explanation and interpretation of early modern national integration, ecohistorical determinants, social and ethnoconfessional  structures and processes. Such a project is expected to contribute substantially to filling the gaps in the historiography, to establish a more balanced perception of the past, along with the improvement of mutual understanding between Croatia and Turkey, with positive effect in the Southeastern Europe. Also, this project can significantly contribute to the  revitalization of the Ottoman heritage in Croatia.]]></summary_en></project><project>
<id>2307</id><title_hr><![CDATA[Metakognicija kod kategorijalnog učenja, mišljenja i razumijevanja]]></title_hr><title_en><![CDATA[Metacognition in Category Learning,  Thinking and Comprehension]]></title_en><user_id>4615</user_id><user_firstLast_name>Dražen Domijan</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2013-11</proposal_call><code>IP-2013-11-4139</code><acronim><![CDATA[METCALTHIC]]></acronim><duration>01.10.2014 - 30.09.2017</duration><status>Završio</status><financ_value>52.918,57 eur</financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Psihologija, </scie_field_hr><scie_field_en>Psychology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Filozofski fakultet u Rijeci]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Humanities and Social Sciences]]></institution_en><team_members_id>4612, 6976, 568, 7004, 5747, 7169, 6968, 6882, 6892, 17886, </team_members_id><team_members_names><![CDATA[Igor Bajšanski, Pavle Valerjev, Valnea Žauhar, Mia  Šetić, Marija Šakić, Vladimir Takšić, Tanja Gulan, Maja Močibob, Nena Vukelić, Mateja Marić, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[metacognition, monitoring, dual processes, category learning, thinking, comprehension]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[The fundamental problem of education is how to create a learning environment which will facilitate the acquisition of knowledge and skills. Psychology of education attempts to identify mental processes and mechanisms underlying our ability to learn. Research on self-regulated learning and metacognition is a topic of special importance for educational psychology. Self-regulated learning encompasses cognitive, motivational and behavioral processes which occur while learners undertake activities to accomplish a learning goal. Self-regulation is based on a cyclical process of monitoring and control. The learner monitors the efficiency of the applied learning strategies and responds to feedback obtained from the monitoring process. Metacognition is studied intensively in the areas of memory and text comprehension. The central aim of the project is to explore metacognitive processes of monitoring and control in the domains of: 1. Category learning, 2. Thinking, 3. Grounded (situated) comprehension. All of these domains have been studied extensively but in isolation from metacognition. Our goal is to bring together these disparate fields of study under the same research program. Unifying theme of the project is the distinction between Type 1 and Type 2 processes which can be identified in each domain and whose properties will guide metacognitive judgments. Project team consists of 5 established researchers in the field of experimental psychology and 5 doctoral students whose PhD theses are closely related to the project aims. The project team will utilize newly established Laboratory for experimental psychology equipped with facilities necessary to carry out the proposed project. The project will answer the important question of how accurate are the metacognitive judgments and how effective are the processes of monitoring and regulation in the cognitive domains where metacognition has not been studied in greater detail.]]></summary_en></project><project>
<id>2314</id><title_hr><![CDATA[Višeagentno modeliranje velikih razmjera za MMORPG mrežne igre ]]></title_hr><title_en><![CDATA[Large-scale Multi-Agent Modelling of Massively Multi-player On-line Role-Playing Games]]></title_en><user_id>891</user_id><user_firstLast_name>Markus Schatten</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2013-11</proposal_call><code>UIP-2013-11-8537</code><acronim><![CDATA[ModelMMORPG]]></acronim><duration>01.10.2014 - 30.09.2017</duration><status>Završio</status><financ_value>66.421,61 eur</financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Informacijske znanosti, </scie_field_hr><scie_field_en>Information sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet organizacije i informatike]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Organization and Informatics]]></institution_en><team_members_id>1428, 1412, 899, 918, 2900, 2725, 2508, 2577, 950, 17828, 21330, </team_members_id><team_members_names><![CDATA[Mladen Konecki, Jurica Ševa, Joaquim  Filipe, Pietro Terna, Nikola Ivković, Ivan Magdalenić, Igor Tomičić, Robert Kudelić, Marko Maliković, Bogdan Okreša Đurić, Mario Konecki, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[large-scale multi-agent systems, agent based modeling, mmorpg, organizational methods, organizational design, artificial intelligence]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Massively multi-player on-line role playing games (MMORPGs) give us the opportunity to study two important aspects of computing: (1) large-scale virtual social interaction of people (players) and (2) the design, development and coordination of large-scale distributed artificial inteligence (AI). A common denominator for both aspects are the methods used to study them: social interaction can be descibed and simulated using agent-based models (ABM social science perspective) whilst distributed AI is commonly modelled in terms of multi-agent systems (MAS computer science perspective). The important question to ask in both perspectives is how do agents organize in order to perform their tasks and reach their objectives? Herein we will employ a combined empirical and theoretical approach towards finding the answer to this question.From the empirical side, we shall study the human behaviour on a number of venues across various gaming servers in order to find most suitable structures, cultures, processes, strategies and dynamics employed by most successful player communities.  From the theoretical side, we shall test a multitude of organizational architectures from organization theory in various MMORPG settings, and compare them with methods found in empirical research.Our research is therefore aimed towards enriching the organizational design methods for the development of MMORPG to foster the development of self-organizing and adaptable networks of large-scale multi-agent systems.With this in mind, our main goals are:1) To identify and formalize adequate organizational design methods for developing LSMAS in MMORPGs.2) To couple them with real-life and future scenarios from industry.3) To provide open and accessible tools, which will allow for design, development, implementation, control, simulation and maintenance of LSMAS in MMORPG.]]></summary_en></project><project>
<id>2317</id><title_hr><![CDATA[Ekonomski i socijalni učinci reformi energetskog sektora na održivi ekonomski rast]]></title_hr><title_en><![CDATA[Economic and social effects of energy sector reforms on sustainable economic growth]]></title_en><user_id>211</user_id><user_firstLast_name>Nela Vlahinić-Dizdarević</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2013-11</proposal_call><code>IP-2013-11-2203</code><acronim><![CDATA[ESEESRSEG]]></acronim><duration>01.06.2014 - 31.05.2018</duration><status>Završio</status><financ_value>68.630,13 eur</financ_value><scie_area_hr>Društvene znanosti, Tehničke znanosti, </scie_area_hr><scie_area_en>Social sciences, Technological sciences, </scie_area_en><scie_field_hr>Ekonomija, </scie_field_hr><scie_field_en>Economy, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Ekonomski fakultet]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Economics and Business]]></institution_en><team_members_id>2915, 2618, 6336, 19024, 6206, 7269, </team_members_id><team_members_names><![CDATA[Saša Žiković, Pavle Jakovac, Rafal Weron, Ivan Gržeta, Ana-Maria Boromisa, Đula Borozan, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[energy sector, reforms, economic effects, social effects, sustainable economic growth, Croatia, European Union]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Sustainable economic growth needs a sustainable energy supply. In order to accomplish this goal, good economic governance incorporating energy policy should implement reforms that will increase economic efficiency and social prosperity. The sector’s reform experience goes back to the beginning of 1990s, indicating that existing literature has been limited by a relatively short period of time, inadequate hypothesis cross-testing and without appropriate panel-data analysis. Therefore there is a strong need for the systematic analysis that would include EU countries and Croatia as the new EU Member State, a broader range of issues related to energy sector reforms within a longer time frame to examine whether the empirical evidence supports the logic of reforms and to compare the existing evidence on the reform determinants and performance. So far the findings on some issues have been limited and inconclusive. The goal of the research is to better understand the reform process by providing solid economic evidence on energy reform results and its economic and social impacts on sustainable growth. The aim of the research within this project is to address several related issues: 1) internal and external factors that will further influence the progress of reforms, especially in the EU; 2) macroeconomic performance, institutional settings, regulatory prudence and sector governance as the important wider framework; 3) measuring the economic impact of energy reforms in terms of economic efficiency, rate of investments, competitiveness and economic growth; 4) testing the existing risk management models and developing a novel approach to assessing and hedging the risks in the energy market; 5) measuring the social impact of energy reforms in terms of coverage of energy services and welfare; 6) evaluation of the energy reforms impact on long-term and sustainable economic growth. The research will be performed by combining economic and technical approach and research methods.]]></summary_en></project><project>
<id>2322</id><title_hr><![CDATA[Istraživanje inovativnih zelenih tehnologija na kampusima za potrebe održivog društva]]></title_hr><title_en><![CDATA[Innovative Green Building Research in the Campus Living Lab]]></title_en><user_id>7223</user_id><user_firstLast_name>Bojan Baletić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2013-11</proposal_call><code>IP-2013-11-8596</code><acronim><![CDATA[CampusLivingLAB]]></acronim><duration>01.09.2014 - 31.08.2017</duration><status>Završio</status><financ_value>98.347,60 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Arhitektura i urbanizam, </scie_field_hr><scie_field_en>Architecture and Urban Environment, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Arhitektonski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Architecture]]></institution_en><team_members_id>7216, 7232, 5972, 7319, 7503, 7540, 7520, 3715, </team_members_id><team_members_names><![CDATA[Roberto Vdović, Morana Pap, Rene Lisac, Kristina Careva, Mladen Jošić, Ljubomir Miščević, Velimir  Tolić, Zoran Veršić, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[Architecture, Campus, Green technology, Sustainable Development, Innovative Design]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[The aim of the project is to research and develop an innovative model for a green building (based on student housing) on the campus that could be certified as A+ by applying new materials and technologies, the climate sensitive design approach and testing the possible alternatives with the future users in alignment with the Living laboratory principles.Our research is an extension of the present green campus multidisciplinary research and development. It belongs in the architecture domain, but it also includes interdisciplinary participation from other professions. We refer to the university campus Borongaj in Zagreb as an explicit framework of our research. The plan is to build it as a green campus with the highest level of energy efficiency. In its full form, that campus should be a place for studying, working, learning and living for about 20,000 academic citizens. For that reason, it was necessary to design a complex system and implement cutting-edge green technology and energy efficiency principles: bioclimatic principles of renewable energy sources, advanced technology, smart systems, and user adoptation of the new environment and technology within the methodology of the living laboratory concept.In the proposed three year project the team would research new materials, building elements and construction methods to define those appropriate for implementation. Using Building Information Management software and sustainable design principles the team will develop alternative building proposals that will be analyzed based on detailed energy, cost/benefit and quality of life simulations. The input from the construction industry is also planned. The third phase of the project is a testing phase in which, through student surveys and direct input from a selected group of students, the team expects to refine the proposals. In the end the research result needs to be evaluated within the high expectations of the green campus concept.]]></summary_en></project><project>
<id>2330</id><title_hr><![CDATA[Primjena nusproizvoda prehrambene industrije za razvoj funkcionalnih i okolišno prihvatljivih ekstrudiranih proizvoda i aditiva ]]></title_hr><title_en><![CDATA[Application of food industry by-products in development of functional and environmentally friendly extruded food products and additives]]></title_en><user_id>6031</user_id><user_firstLast_name>Drago Šubarić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2013-11</proposal_call><code>IP-2013-11-1321</code><acronim><![CDATA[FUNEXFOOD]]></acronim><duration>16.06.2014 - 15.06.2018</duration><status>Završio</status><financ_value>117.902,01 eur</financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Prehrambena tehnologija, </scie_field_hr><scie_field_en>Food technology, </scie_field_en><institution_hr><![CDATA[Sveučilište Josipa Jurja Strossmayera u Osijeku, Prehrambeno-tehnološki fakultet]]></institution_hr><institution_en><![CDATA[Josip Juraj Strossmayer University of Osijek, Faculty of Food Technology]]></institution_en><team_members_id>5709, 6520, 4090, 6811, 5095, 5982, 5097, 5093, 4578, 3836, 5723, 4879, 6084, 17789, </team_members_id><team_members_names><![CDATA[Antun Jozinović, Marko Jukić, Indira Kosović, Daliborka Koceva Komlenić, Gordana Šimić, Dijana Miličević, Alojzije Lalić, Jurislav Babić, Đurđica Ačkar, Stela Jokić, Borislav Miličević, Biljana Pajin, Midhat Jasic, Jelena Panak, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[Functional food, extrusion, cereals, flours, by-products, environment-friendly]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Consumers nowadays are seeking palatable food which has beneficial effect on health. At the same time, they are not ready to change their eating habits – reduce intake of bakery products, fast food etc. and increase intake of fresh fruit and vegetable, whole grain products etc. Therefore, food industry is challenged to create products that are consumed every day (bread, snacks etc.) by large population, which are both enriched with bioactive substances and have desired sensory properties.The aim of this project is to develop new functional and enriched products based on extrusion process. Enriched grains (wheat, maize) will be used as basic material. The improvement and supplementation with biologically active (antioxidants, minerals, vitamns, fibre) will be done by addition of by-products from food industry (fruit and vegetable pomaces, oil cakes) in extrusion process. Extrusion will be used to produce final products: expanded snack products and pasta, as well as modified flours which will be used in production of bakery products and biscuits.All processes - extrusion of snack products and pasta, extrusion for flour modification, pasta drying, baking) will be optimised using response surface methodology. All products will be tested for chemical, physical, thermophysical properties, and optimal products will be sensory analysed.The results of project will be array of flours and final products with defined recipes and optimal production conditions, along with defined application of food industry by-products that significantly load environment and are not currently exploited to satisfying extent.In the project multidisciplinary approach will be applied – from agronomist, over food technologist and process engineers to sensory experts. In addition, close academia-industry links will be developed through different activities.]]></summary_en></project><project>
<id>2332</id><title_hr><![CDATA[Trehaloza: poboljšanje kvalitete proizvoda na bazi voća]]></title_hr><title_en><![CDATA[Trehalose: fruit product quality improvement]]></title_en><user_id>7246</user_id><user_firstLast_name>Mirela Kopjar</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2013-11</proposal_call><code>UIP-2013-11-6949</code><acronim><![CDATA[TrehaMovement]]></acronim><duration>01.09.2014 - 31.08.2017</duration><status>Završio</status><financ_value>93.202,73 eur</financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Prehrambena tehnologija, </scie_field_hr><scie_field_en>Food technology, </scie_field_en><institution_hr><![CDATA[Sveučilište Josipa Jurja Strossmayera u Osijeku, Prehrambeno-tehnološki fakultet]]></institution_hr><institution_en><![CDATA[Josip Juraj Strossmayer University of Osijek, Faculty of Food Technology]]></institution_en><team_members_id>7296, 7330, 7400, 7405, 7410, </team_members_id><team_members_names><![CDATA[Anita Pichler, Josip Simunovic, Nela Nedić Tiban, Ante Lončarić, Tomaž Požrl, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[trehalose,  fruit products, colour, aroma, texture, trehalose action ]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Trehalose is a nonreducing disaccharide which consists of two D-glucose units linked by a-a (1-1)-linkage and occurs widely in nature. Its unique hydration structure enables it to interact with both hydrophilic and hydrophobic molecules which probably contribute to the multifunctional character of trehalose. The major applications of trehalose have been in science, medicine and cosmetic sectors due to its natural functionality, mechanism of action and technical qualities. The limiting factor of trehalose use in the food industry used to be the ingredient cost but with development of a new manufacturing process, the cost of trehalose production has been dramatically reduced. It is about 45% as sweet as sucrose and very stable under processing and storage conditions. Texture, colour and aroma are the main quality attributes influencing consumer acceptability of fruit products. During formulation of fruit products different additives are often used to obtain desired properties of semi-products or final products. The aim of this project is investigation of the influence of trehalose on fruit product quality with emphasis on the explanation of trehalose mechanism of action in complex fruit product matrices. Practical application of project results would be valuable for new food product development. Through addition of trehalose to fruit product the retention of key aroma compounds, and prevention of colour degradation could be achieved, ensuring in this way more fresh-like characteristics of the final product. Also, through retention of phenols, especially pigments, such as anthocyanins, which are known for their antioxidant properties, obtained products would have higher nutritional value, as well as organoleptic properties.]]></summary_en></project><project>
<id>2333</id><title_hr><![CDATA[Komparativnoslavističke lingvokulturalne teme]]></title_hr><title_en><![CDATA[Comparative Slavic Linguocultural Themes]]></title_en><user_id>3640</user_id><user_firstLast_name>Neda Pintarić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2013-11</proposal_call><code>IP-2013-11-2131</code><acronim><![CDATA[KOMPAS]]></acronim><duration>01.09.2014 - 31.08.2018</duration><status>Prekinut</status><financ_value>61.862,10 eur</financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Filologija, </scie_field_hr><scie_field_en>Philology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Filozofski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Humanities and Social Sciences]]></institution_en><team_members_id>6803, 5453, 6916, 3642, 6906, 5457, 4124, 5183, 7079, 7046, 6970, 5456, 5554, 5446, 7052, 6367, 5365, 7341, 5571, 7361, </team_members_id><team_members_names><![CDATA[Dubravka Sesar, Ivana Vidović, Aleksandra Welna, Miroslav Hrdlička, Jerzy Molas, Josip  Lasić, Ivana Čagalj, Ana Vasung, Elżbieta Wrocławska, Slavomira Ribarova, Martina Grčević, Szerszunowicz Joanna, Oksana Timko Đitko, Borjana Prošev-Oliver, Lidija Cvikić, BARBARA POPIOŁEK, Anita Skelin Horvat, Ewa Komorowska, Marinela  Aleksovski, Branko Kuna, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[Slavistics, Culturology, Pragmatics, Sociolinguistics, Phraseology, Lexicology, Stylistics, Language History, Gtottodidactics]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[The Project will include linguocultural themes from Slavic philology with an emphasis on Croatian language using a contrastive/comparative method of research. Languages included are: Polish, Czech, Slovak, Ukraine, Russian, Sorabian, Macedonian, Bulgarian and other Slavic languages.Linguocultural  areas cover grammatical fields: phonology, inflexion, word- formation, lexicology, phraseology, micro -, macro- and suprasyntax and wider areas of interest are: pragmatics, paremiology, language history and semantics. Interdisciplinary areas, such as: ethno linguistics, sociolinguistics, psycholinguistics with a special emphasis on verbal and non-verbal communication are also taken into consideration. On the basis of this a connection of the language and culture in presenting the language world view will be presented.As a part of the Project specialized bilingual dictionary “Pragmaticon” and Quintilingual dictionary of Slavic etymons. ]]></summary_en></project><project>
<id>2335</id><title_hr><![CDATA[Napredni elektromotorni pogoni za primjene u vuči]]></title_hr><title_en><![CDATA[Advanced Electric Drives for Traction Applications]]></title_en><user_id>3873</user_id><user_firstLast_name>Damir Žarko</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2013-11</proposal_call><code>IP-2013-11-7801</code><acronim><![CDATA[ELTRAC]]></acronim><duration>01.10.2014 - 30.09.2018</duration><status>Završio</status><financ_value>128.940,21 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Elektrotehnika, </scie_field_hr><scie_field_en>Electrical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id>1505, 1528, 2534, 2524, 2674, 2703, 2913, 3279, 3953, 3938, 5856, 6481, 7357, 18971, 17824, </team_members_id><team_members_names><![CDATA[Goran Rovišan, Stjepan Stipetić, Marinko Kovačić, Željko Jakopović, Ivan Mrčela, Mario Vražić, Viktor Šunde, Tanja Poljugan, Zlatko Hanić, Ivan Gašparac, Neven Čobanov, Šandor Ileš, Fetah Kolonić, Ana Hanić, Tino Jerčić, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[electric traction, electric drives, energy efficiency, optimization, life cycle cost, control of electric drives, power electronics, electric machines]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[The development of more efficient transport equipment and reduction of their environmental footprint is in the scope of the energy policy of the EU. The electrification of the transport equipment and the shift of the freight shipments from road to more efficient rail are some of the key elements for the overall increase of energy efficiency in transport and reduction of the greenhouse gas emissions. This project puts emphasis on development of advanced electric drives for traction vehicles for passenger and freight transport running on tracks. Traditional approach to the design of electric drives has an emphasis on components without insufficient insight into the interaction among them and thus it fails to deliver the optimal performance of the overall traction system. The main objective of this project is to enhance the general approach to design of electric drive systems for traction applications by utilizing a synergetic approach to component design accompanied with advanced control algorithms to maximize the system performance and efficiency and minimize the life cycle cost of the vehicle. This objective will be achieved through: (i) development of software tools for computer aided design of electric drive components for traction applications using multiphysics approach with consideration of component interaction with the rest of the system, (ii) development of different traction power converters topologies for evaluation of various modulation and control methods, (iii) development of software environment for dynamic simulation of traction system performance which couples complex nonlinear models of system components with the models of control algorithm and vehicle dynamics, (iv) development of the electric drive control system based on optimal control approach which ensures maximum efficiency of the system during entire drive cycle of the vehicle. The developed algorithms will be experimentally tested on the scaled model of the traction system.]]></summary_en></project><project>
<id>2338</id><title_hr><![CDATA[ISTRAŽIVANJE JAVNE POTROŠNJE NA OBRAZOVANJE: UTJECAJ NA RAST, KONVERGENCIJA I EFIKASNOST]]></title_hr><title_en><![CDATA[INVESTIGATING GOVERNMENT SPENDING ON EDUCATION: GROWTH EFFECTS, CONVERGENCE AND EFFICIENCY]]></title_en><user_id>1210</user_id><user_firstLast_name>Lena Malešević Perović</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2013-11</proposal_call><code>UIP-2013-11-9558</code><acronim><![CDATA[GOVSPENDEDU]]></acronim><duration>15.09.2014 - 14.09.2017</duration><status>Završio</status><financ_value>27.951,49 eur</financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Ekonomija, </scie_field_hr><scie_field_en>Economy, </scie_field_en><institution_hr><![CDATA[Sveučilište u Splitu, Ekonomski fakultet]]></institution_hr><institution_en><![CDATA[University of Split, Faculty of Economics, Business and Tourism]]></institution_en><team_members_id>2515, 2526, </team_members_id><team_members_names><![CDATA[Maja Mihaljevic Kosor, Silvia Golem, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[PUBLIC SPENDING, EDUCATION, GROWTH, CONVERGENCE, EFFICIENCY]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[More and more governments are increasingly recognising the importance of human capital for growth and prosperity of their countries; moreover, European Commission has stated education as one of its key 2020 goals. These plans are, however, in contrast with the EU fiscal policies which are faced with constraints as regards deficits and public debts. Public spending on education should, therefore, be given special attention. This research project, consequently, has three main goals, which are as follows: to analyse the relationship between public spending on education and GDP growth; to investigate whether there is a convergence between public spending on education among the EU countries and to analyse the efficiency of public spending on education in the EU countries.  ]]></summary_en></project><project>
<id>2342</id><title_hr><![CDATA[Statističko modeliranje odgovora na krizu i ekonomskog rasta zemalja Zapadnog Balkana]]></title_hr><title_en><![CDATA[Statistical Modelling for Response to Crisis and Economic Growth in Western Balkan Countries]]></title_en><user_id>3292</user_id><user_firstLast_name>Ksenija Dumičić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2013-11</proposal_call><code>IP-2013-11-9402</code><acronim><![CDATA[STRENGTHS]]></acronim><duration>01.09.2014 - 31.01.2019</duration><status>Završio</status><financ_value>51.536,00 eur</financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Ekonomija, </scie_field_hr><scie_field_en>Economy, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Ekonomski fakultet u Zagrebu]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Economics and Business]]></institution_en><team_members_id>6268, 3738, 3373, 3372, 3492, 3285, 3464, 4258, 6350, 3528, 4043, 3608, 3669, 3727, </team_members_id><team_members_names><![CDATA[Vlasta Bahovec, Ivan Strugar, Anita Čeh Časni, Irena Palić, Berislav Žmuk, Dajana Cvrlje, Silvija Vig, Vesna Bucevska, Lea Bregar, Emina Resić, Mirna Dumičić, Ivan Huljak, Zrinka Marušić, Iris Mihajlović, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[Econometric Modelling, Panel Data Analysis, Mathematical Programming, Multivariate Analysis Methods, Survey Research Design]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Recent economic downturn has forced policy makers to pay attention both not only on the economic growth, but as well on risk prevention. However, intelligent decision cannot be made without previous thorough analysis using appropriate methods. Project “STatistical modelling for Response to crisis and EcoNomic GrowTH in Western Balkan countrieS” (STRENGTHS) aims to support joint action of analysts, managers and policy makers, which is crucially needed in order to attain the goal of prosperity. Project team members are leading reserachers from Croatian, Slovenian, Bosnia and Herzegovina and Macedonian HEIs, researchers from the corporate world, and National Bank of Croatia. Prinicipal investigator and researchers have identified number of goals as significant for the crisis prevention and economic growth, which cannot be achieved without the insight acquired as a result of thoughtful statistical analysis. Crisis prevention topics will be investigated: Risk and financial management modelling, Commitment to business ethics and its influence on a corporation&#39;s performance, Efficiency of macroprudential measures and measuring financial stability, and Statistical modelling of the impact of macroeconomic shocks on small open economy. Economic growth topics will be investigated: Statistical modelling of housing wealth effect on personal consumption in selected WB countries, Modelling migration from the EU candidate countries, Impact of statistical methods usage to business performance, Estimating the value of public goods in tourism: Application of Contingent Valuation Method on the Case of Croatia, Strategic impact of the Internet usage on the tourism industry, and The net effect of bank market power in CEE countries. These goals will be achieved by the survey research, thoroughly prepared researched instruments, and usage of cutting-edge statistical methods (Econometric Modelling, Panel Data Analysis, Mathematical Programming, and Multivariate Methods).]]></summary_en></project><project>
<id>2349</id><title_hr><![CDATA[Modeliranje toka podzemnih voda u krškim vodonosnicima]]></title_hr><title_en><![CDATA[Groundwater flow modelling in karst aquifers]]></title_en><user_id>6687</user_id><user_firstLast_name>Hrvoje Gotovac</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2013-11</proposal_call><code>UIP-2013-11-8103</code><acronim><![CDATA[Karst modelling]]></acronim><duration>01.10.2014 - 31.01.2018</duration><status>Završio</status><financ_value>127.148,45 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Građevinarstvo, </scie_field_hr><scie_field_en>Civil engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Splitu Fakultet građevinarstva, arhitekture i geodezije]]></institution_hr><institution_en><![CDATA[University of Split, Faculty of Civil Engineering, Architecture and Geodesy]]></institution_en><team_members_id>6169, 6989, 7099, 6856, 7030, 6042, 7164, 17887, 21318, </team_members_id><team_members_names><![CDATA[Vedrana Kozulić, Blaž Gotovac, Roko Andricevic, Vinko Jovic, Veljko Srzić, Ivo Andrić, Srdjan Simunovic, Luka Malenica, Grgo Kamber, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[karst aquifers, groundwater flow modeling, multiresolution and multiscale approach, karst heterogeneity, distributive karst models]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Karst aquifers are very important groundwater resources around the world as well as in coastal part of Croatia. They consist of extremely complex structure defining by triple phases: slow porous medium, mostly laminar fractures and usually fast turbulent conduits/karst channels. Usually, karst aquifers have been analyzed by lumped hydrological models which ignore high heterogeneity of karst and consider only input (precipitation) and output (spring discharge) due to lack of extensive other input data and knowledge regarding the karst system. Last two decades full hydraulic (distributive) models have been developed exclusively by conventional finite elements considering karst heterogeneity structure that improves our understanding of complex processes in karst. Therefore, in this project we will develop novel “unique” flow model based on multi-resolution approach originally designed by Gotovac et al. (2007-2013) for 1-D and 2-D groundwater flow and transport simulations. Proposed approach is based on Fup basis functions with compact support and meshless collocation procedure enabling multi-scale representation of heterogeneity and other flow variables, closely related to the karst flow physical interpretation. Moreover, extending existing procedure to 3-D and constructing separate multi-scale solution for all three karst phases, proposed approach will enable the following impacts in comparison to conventional methods: desired spatial and temporal accuracy and high computational efficiency, modular model structure, incorporation of different heterogeneity scales related to existing measurements, enabling of transport and tracer test analysis and better understanding of karst aquifers due to solving of different engineering problems such as water usage and protection or contaminant pollution. Flow model will be verified by laboratory experiments and numerical synthetic benchmarks as well as real examples such as Jadro catchment and Ombla underground accumulation.]]></summary_en></project><project>
<id>2351</id><title_hr><![CDATA[Upravljanje prostorno distribuiranim dinamičkim sustavima]]></title_hr><title_en><![CDATA[Control of Spatially Distributed Dynamical Systems]]></title_en><user_id>7315</user_id><user_firstLast_name>Andrej Jokić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2013-11</proposal_call><code>UIP-2013-11-9354</code><acronim><![CDATA[ConDis]]></acronim><duration>01.09.2014 - 31.08.2017</duration><status>Završio</status><financ_value>121.401,55 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Strojarstvo, </scie_field_hr><scie_field_en>Mechnical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet strojarstva i brodogradnje]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Mechanical Engineering and Naval Architecture]]></institution_en><team_members_id>6421, 5441, 6544, 6498, 6493, 17859, </team_members_id><team_members_names><![CDATA[Vladimir Milić, Marko Jokić, Josip Kasać, Mladen Crneković, Tihomir Žilić, Mihael Lobrović, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[control systems, distributed control, optimization, large-scale systems, vibrations]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Following impressive developments in communication and information technologies, but also in sensor and actuator technologies, a whole set of novel products and systems has emerged, which only recently seemed unfeasible. Examples of such systems include the so-called smart structures composed of a large number of sensors and actuators mounted on constructive elements (beams/plates) with the goal to damp undesired vibrations or to control flow of fluids; adaptive optics with large amount of optical elements; smart electrical power systems; highways with automated cars driving in platoons. Common characteristic of all of the above mentioned systems is that they are composed of a large number of spatially distributed dynamical subsystems which operate under constant mutual interactions through some physical interconnections (network) and/or communication links (network). Today, it is widely acknowledged that the key challenge in development of such dynamical networks is synthesis of algorithms for their control. The main goal of this project is development of some of the key elements in fundamental theory of control for spatially distributed systems, together with constructive controller synthesis algorithms suitable for application in real-life problems. The research focus will be on distributed control solutions in which each dynamical system in the network is controlled by its local controller and each local controller communicates and coordinates its actions with a (usually small) set of directly neighboring controllers. Our approach will be based on innovative elements from the theory of dissipative systems, while both spatially invariant networks and generic dynamical networks with arbitrary interconnection graph will be considered. The developed control algorithms will be verified in laboratory experiments on groups of mobile robots and on a distributed vibration control platform.]]></summary_en></project><project>
<id>2352</id><title_hr><![CDATA[Europska bioetika na djelu]]></title_hr><title_en><![CDATA[European Bioethics in Action]]></title_en><user_id>4099</user_id><user_firstLast_name>Amir Muzur</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2013-11</proposal_call><code>IP-2013-11-7853</code><acronim><![CDATA[EuroBioAct]]></acronim><duration>15.09.2014 - 14.09.2017</duration><status>Završio</status><financ_value>50.434,67 eur</financ_value><scie_area_hr>Humanističke znanosti, Društvene znanosti, Biomedicina i zdravstvo, </scie_area_hr><scie_area_en>Humanities, Social sciences, Biomedicine and health sciences, </scie_area_en><scie_field_hr>Filozofija, </scie_field_hr><scie_field_en>Philosophy, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Medicine]]></institution_en><team_members_id>6036, 5496, 5108, 5105, 6779, 5129, 5896, 5503, 6539, 5594, 21391, </team_members_id><team_members_names><![CDATA[Ante  Čović, Robert Doričić, Igor Eterović, Nada Gosić, Željko Kaluđerović, Iva Rinčić, Tomislav Rukavina, Hans-Martin Sass, Vanja Vasiljev Marchesi, Valerije Vrček, Maja Miloš, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[Europe, integrative bioethics, Fritz Jahr, ecology, environment, Northern Adriatic]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[The „European Bioethics in Action (EuroBioAct)” project primarily aims at:	1. completing theoretical basis for the „new European bioethics“ (by rounding-up 	research on Fritz Jahr, Ignaz Bregenzer, and other thinkers and conceiving a 	common platform with integrated ideas of modern environment science and 	ethics) and	2. applying that theoretical basis in practice (by compiling a list of „bioethical 	standards“ for settlements, containing concrete general and specific norms for 	preservation and improvement of local eco-systems – i.e., human health, animal 	and plant welfare, etc.).In the first phase of the project realisation, the participants would continue with the broadening and deepening of the theoretical basis of the „new European bioethics“ primarily by completing the research of the life and work of Fritz Jahr and his most important models (Ignaz Bregenzer and others). In the second phase of the project, three focused workshops would be organised determining the status of the general and special ecological needs for the three local communities (Plomin, Bakar, and Mali Lošinj) from the Northern Adriatic region. The three communities selected to host the workshops have either been recently experiencing ecological threats (Plomin – thermo-electric power plant; Bakar – cokery), or represent a highly-valuable and vulnerable natural insular pocket (Mali Lošinj – health tourism, dolphin wildlife refuge, fragrant gardens programme, etc.). Based on the theoretical background and the insights provided by the workshops, in the third phase of the project, created would be the „bioethical standards“, that is, a set of principles and measures of the correct relation of men toward their own health, animals, plants, and the eco-system in total. A „bioethical standards“ charter might improve the level of local community environmental consciousness, and provide direction lines for its sustainable development (including a potential tourism-advertising ace card).]]></summary_en></project><project>
<id>2353</id><title_hr><![CDATA[Znanstveno brendiranje svinjskog mesa]]></title_hr><title_en><![CDATA[Scientifically Branded Pork]]></title_en><user_id>1296</user_id><user_firstLast_name>Goran Kušec</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2013-11</proposal_call><code>IP-2013-11-3396</code><acronim><![CDATA[SciBra Pork]]></acronim><duration>01.07.2014 - 30.06.2018</duration><status>Završio</status><financ_value>112.718,49 eur</financ_value><scie_area_hr>Biotehničke znanosti, Prirodne znanosti, </scie_area_hr><scie_area_en>Biotechnical sciences, Natural sciences, </scie_area_en><scie_field_hr>Poljoprivreda, </scie_field_hr><scie_field_en>Agriculture, </scie_field_en><institution_hr><![CDATA[Sveučilište Josipa Jurja Strossmayera u Osijeku, Fakultet agrobiotehničkih znanosti Osijek]]></institution_hr><institution_en><![CDATA[Josip Juraj Strossmayer University of Osijek, Faculty of Agrobiotechnical Sciences in Osijek]]></institution_en><team_members_id>2738, 6830, 4653, 7523, 1230, 7603, 7607, 7608, 3831, 19548, 21307, 13307, 13691, 20761, </team_members_id><team_members_names><![CDATA[Boris Lukić, Vladimir Margeta, Kristina Budimir, Snježana Džijan, Zinka Bošnjak, Ivona Durkin, MARINA  KRVAVICA, MARKO  JELIĆ, Kristian Sabo, Miodrag Komlenić, Mane Medić, Ivan Kelić, Zdravko  Tolušić, Polonca Margeta, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[indigenous pig breed, genomic identification, growth characteristics, carcass and meat quality, sensory traits, meat products, branding]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Black Slavonian pig is an autochthonous pig breed, established at the end of the 19th century near Osijek in eastern Croatia. The breed is black in color, resistant and convenient for keeping in extensive and half-extensive conditions. It is also characterized by good meat quality, suitable for producing typical traditional meat products. Recently, the traditionally produced food came into the focus which led to more often use of geographical indications (protected designation of origin-PDO, protected geographical indication-PGI and Traditional Specialties Guaranteed-TSG) as the valuable rural development strategy. Since Black Slavonian pig is a late maturing breed characterized by low lean meat percentage, meat processors tend to use the meat of modern pig breeds in production of traditional products. Therefore there is a need for scientifically developed methods in order to trace the origin of materials used in such production. First of all, molecular identification of breed will be performed by the use of MC1R gene and 18 microsatelite primers . Since the genotype, age and sex are possible sources of variation of the meat quality traits in pigs, the objective of proposed research is to determine the optimal time for slaughter with respect to these factors. The genetic influence on meat quality traits is nowadays well described by the use of molecular markers by which many of the candidate genes were discovered. In proposed research a special interest will be placed at some of them such as IGF2, MC4R, H-FABP3 and LEPR. The investigation of sensory traits and chemical analysis of meat and meat products will help to determine the typical physico-chemical characteristics and sensory profile of autochthonic Slavonian dry-cured meat products and fresh meat originated from Black Slavonian Pig meat. At the end, obtained polymorphisms at the microsatellite loci will be tested in identification of the origin of meat used in the production of traditional meat products.]]></summary_en></project><project>
<id>2360</id><title_hr><![CDATA[Razvoj formulacija novih prirodnih insekticida na osnovi inertnih prašiva i botaničkih insekticida i njihovih kombinacija kao zamjena za sintetske konvencionalne insekticide]]></title_hr><title_en><![CDATA[Development of new natural insecticide formulations based on inert dusts and botanicals to replace synthetic, conventional insecticides ]]></title_en><user_id>4063</user_id><user_firstLast_name>Vlatka Rozman</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2013-11</proposal_call><code>IP-2013-11-5570</code><acronim><![CDATA[DIACROMIXPEST]]></acronim><duration>01.07.2014 - 30.06.2017</duration><status>Završio</status><financ_value>95.557,05 eur</financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Poljoprivreda, </scie_field_hr><scie_field_en>Agriculture, </scie_field_en><institution_hr><![CDATA[Sveučilište Josipa Jurja Strossmayera u Osijeku, Fakultet agrobiotehničkih znanosti Osijek]]></institution_hr><institution_en><![CDATA[Josip Juraj Strossmayer University of Osijek, Faculty of Agrobiotechnical Sciences in Osijek]]></institution_en><team_members_id>4202, 4081, 4365, 4414, 4277, 5109, </team_members_id><team_members_names><![CDATA[Zlatko Korunic, Josip Halamić, Anita Liška, Pavo Lucić, Ines Galović, Renata Baličević, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[natural insecticides, inert dusts, botanical insecticides, stored pest, stored products]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Croatia has a low tolerance for detectable insects in stored grain so stored pests must be controlled. The conventional choice, organosphosphates and pyrethroids, has many disadvantages due to considerable hazard of harmful residues, high cost, and the possible and already present appearance of insect resistance. The possible alternative, diatomaceous earth (DE), because of the needs to use high concentrations to control insects, is hindered by its effect on grain flow, bulk density and very high cost. Therefore, there is a great need for the development of a new, less toxic and less dangerous insecticide(s) to control insect pests of stored food and in Public Health/Pest Control field. Synergism of DE and botanicals allows effective control with much lower concentrations of active ingredients, in comparison when these components are used separately. The mode of action is a synergistic combination of desiccation, poisoning and (probably) starvation. Croatia has several sources of DE that are still not in use. These DEs have a potential to be used as natural insecticides or combining it with other natural substances to develop safe, effective and natural insecticide. Also, Croatia has a botanical diversity of indigenous plants. However, the country has not yet benefited from this wealth of knowledge on the use of plants as pesticides. These results make us confident that there is a possibility to develop the new natural synergized insecticide formulation(s) using Croatian DE and plant extract. The proposed project fits the goals and strategic priorities CSF because it encourages the international competitiveness of research groups,developing scientific field that provides the technological advances applicable to agriculture, food industry, public health, communal hygiene and veterinary medicine as well as the ability to obtain new Croatian natural products.]]></summary_en></project><project>
<id>2361</id><title_hr><![CDATA[Prospektivno biopsihosocijalno istraživanje utjecaja seksualno eksplicitnih materijala na socijalizaciju i zdravlje mladih]]></title_hr><title_en><![CDATA[Prospective Biopsychosocial Study of the Effects of Sexually Explicit Material on Young People&#39;s Sexual Socialization and Health]]></title_en><user_id>5817</user_id><user_firstLast_name>Aleksandar Štulhofer</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2013-11</proposal_call><code>IP-2013-11-9221</code><acronim><![CDATA[PROBIOPS SEM STUDY]]></acronim><duration>01.09.2014 - 31.01.2019</duration><status>Završio</status><financ_value>59.773,14 eur</financ_value><scie_area_hr>Društvene znanosti, Biomedicina i zdravstvo, </scie_area_hr><scie_area_en>Social sciences, Biomedicine and health sciences, </scie_area_en><scie_field_hr>Sociologija, </scie_field_hr><scie_field_en>Sociology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Filozofski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Humanities and Social Sciences]]></institution_en><team_members_id>7228, 5502, 2880, 18914, 17799, 21385, 24320, </team_members_id><team_members_names><![CDATA[Vesna Buško, Ivan Landripet, Jadranka Knežević Ćuća, Marija Brajdić Vuković, Goran Koletić, Ksenija Klasnić, Taylor Kohut, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[Prospective study, panel, young people, reproductive and sexual health, emotional intimacy, committed relationships, sexually explicit material]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Digital technology has enabled an unprecedented availability and unrestricted use of sexually explicit material (SEM). As the first experiences with SEM almost invariably precede first sexual experiences, concerns have been raised about its potential impact on young people’s sexual socialization, subsequent reproductive and sexual health outcomes, as well as motivation and capacity for building and maintaining relationship intimacy. The field of socio-behavioural research on SEM has been marred by inability to distinguish between associations and causal links. The only available European panel study followed Dutch youth for only 12 months. To enable a more robust assessment of the links between SEM use and sexual socialization, health, and intimacy we propose to set up a 3-year panel sample with over 1,000 high-school students. The panel would be used to carry out biological testing on males (testosterone levels from saliva) and repeated online surveying in which the genre and the frequency of SEM use would be analyzed as predictors of subsequent sexual activity (particularly, sexual risk taking), the dynamics of attitudes toward women and committed relationships. We propose to test a conceptual model in which possible SEM influences on the outcomes are influenced by T levels, personality traits, family environment, characteristics of ego-centered social network, type of SEM used, and sexual experiences. Our biopsychosocial model aims to assess the contribution of SEM use to the process of young people’s sexual socialization, while controlling for the effects of biological makeup, intrapersonal characteristics, and interpersonal and group (family, peer group, partners) social influences.The proposed project is innovative in design and analytical conceptualization. The expected outcomes should be relevant not only in scientific terms but also in the context of public policy, particularly in the area of educational and public health interventions.]]></summary_en></project><project>
<id>2366</id><title_hr><![CDATA[Optimiranje i modeliranje termalnih procesa materijala]]></title_hr><title_en><![CDATA[Optimisation and modelling of thermal processes of materials]]></title_en><user_id>1419</user_id><user_firstLast_name>Dario Iljkić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2013-11</proposal_call><code>IP-2013-11-5371</code><acronim><![CDATA[OMOTPOM]]></acronim><duration>10.10.2014 - 09.10.2018</duration><status>Završio</status><financ_value>130.068,35 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Strojarstvo, </scie_field_hr><scie_field_en>Mechnical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Tehnički fakultet]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Engineering]]></institution_en><team_members_id>4865, 4866, 7533, 5169, 7373, 3783, 7443, 5116, 3042, 7621, 6646, 4849, 17778, 1422, 25054, </team_members_id><team_members_names><![CDATA[Nikša Čatipović, Zvonimir Dadić, Zvonimir Kolumbic, Branimir  Lela, Mauro Maretić, Hrvoje Novak, Loreta Pomenić, Domagoj Rubeša, Goran Salopek, Sunčana Smokvina Hanza, NEVEN TOMAŠIĆ, Dražen Živković, Lovro Štic, Božo Smoljan, Milenko Jokić, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[materials processing, modelling, electroless plating, electroactive composites, optimisation, modelling]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Phenomena of physical processes during the thermal processes will be investigated. Methods for modeling and computer simulations of thermal processes of materials will be developed. Thermal processes, such as, heat treating processes of steel, hot pressing of powder metals and casting of alloys of light metals will be investigate. The study of heat treatment of steel will be focused on quench hardening and tempering, and control cooling during the hot working and steel casting. Thermal stability of electro-active composites will be analyzed. Optimization of electro-less Ni-P coating of stainless steel and thermo-diffusive heat treatment of layers will be studied. Methods of optimization of application of tools and dies in thermal processing of materials will be studied. Models and computer programs for simulation of behavior steel dies during casting of light metal alloys and hot pressing of metal powders will be developed.During the thermal processes primary will be studied physical processes and material properties such as: heat transfer, microstructure transformations, mechanical properties and distortions and residual stresses. Numerical model of physical phenomena will be preferable based on finite volume method (FVM). To solve these tasks, joined thermo-mechanic-metallurgical approach will be required. The computer program for 3-D simulation of heat transfer, microstructure transformations, mechanical properties, distortions and residual stresses during the thermal processes will be developed.]]></summary_en></project><project>
<id>2368</id><title_hr><![CDATA[Dalmacija kao odredište europskog Grand Toura u 18. i 19. stoljeću]]></title_hr><title_en><![CDATA[DALMATIA - A DESTINATION OF  EUROPEAN GRAND TOUR IN 18th AND 19th  CENTURY]]></title_en><user_id>3905</user_id><user_firstLast_name>Ana Šverko</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2013-11</proposal_call><code>UIP-2013-11-7091</code><acronim><![CDATA[GRANDTOURDALMATIA]]></acronim><duration>01.07.2014 - 30.06.2017</duration><status>Završio</status><financ_value>39.219,59 eur</financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Povijest umjetnosti, </scie_field_hr><scie_field_en>Art history, </scie_field_en><institution_hr><![CDATA[Institut za povijest umjetnosti]]></institution_hr><institution_en><![CDATA[Institute of Art History, Zagreb]]></institution_en><team_members_id>5566, 4910, 3716, 5027, 5171, 5083, </team_members_id><team_members_names><![CDATA[Ivica Covic, Irena Kraševac, Ivana Vlaić, Cvijeta Pavlović, Josip Vrandečić, Iva Raič Stojanović, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[Grand Tour, Dalmatia, Neoclassicism and Romanticism, Representation of Place, Contemporary Urbanscape]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Grand Tour – an exceptional journey which reached its peak in the 18th C, thoroughly changed human perception of nature and society. From the 18 to the 19th C the revolution in natural, human and technical sciences marks the beginning of modern society and contemporary approach in arts and architecture.Although Grand Tour originally focused on Rome, the exploration of  the Ancient World as the origin of Neolassicism widened its travelling radius onto further parts of the Roman Empire, among which Dalmatia held a prominent position. Drawings and literary works by travel artists and writers from that period are treasured in prestigious European museums and libraries and together constitute a priceless  portion of European cultural heritage.For the first time, all known travelogues and drawings about Dalmatia from that period will be collected, analysed and evaluated in terms of literary theory and theory of architecture. The overall aim of the project is to identify, problematise and integrate the issues related to the phenomenon of recording the space, predominantly in Dalmatia. The specific goals of the project are: establishing a working group of young researchers; raising issues of international relevance related to description of Dalmatian space based on works of the 18th and  19th C artists and writers; advancing the development of research methodology; making applicable the research of contemporary cultural-spatial context for critical rethinking in contemporary approach to architecture; creating a platform for further research at international level; establishing a dissemination channel towards both European scientific circles and wider audience.In three years of research the following will be realised: the research of archival records; field research; project webpage; three international workshops; international scientific  conference; public lectures; scientific papers and on-line proceeding book of workshops and conference.]]></summary_en></project><project>
<id>2369</id><title_hr><![CDATA[Očuvanje mikrobne raznolikosti povezane s proizvodnjom tradicionalnih hrvatskih kobasica od mesa  divljači: biotehnološka i sigurnosna karakterizacija]]></title_hr><title_en><![CDATA[Conservation of microbial diversity associated with the production of Croatian traditional game meat sausages: biotechnological and safety characterization]]></title_en><user_id>4884</user_id><user_firstLast_name>Mirna Mrkonjić Fuka</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2013-11</proposal_call><code>UIP-2013-11-6640</code><acronim><![CDATA[miCROgame]]></acronim><duration>01.10.2014 - 30.09.2017</duration><status>Završio</status><financ_value>112.149,23 eur</financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Poljoprivreda, </scie_field_hr><scie_field_en>Agriculture, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Agronomski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Agriculture]]></institution_en><team_members_id>4971, 5628, 17813, 19027, 20375, 20430, </team_members_id><team_members_names><![CDATA[Ivica Kos, Schloter Michael, Ana Žgomba Maksimović, Nataša Hulak, Irina Tanuwidjaja, Blaz Stres, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[traditional game meat sausages, lactic acid bacteria, foodborn pathogens, antibiotic resistance, starter cultures]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Despite the fact that nowadays the utilization of starter cultures is a prerequisite for the meat industry, as product reproducibility, reduction of fermentation times and enhancement of organoleptic characteristics is achieved, small scale producers in Croatia still produce spontaneously fermented game meat sausages as they still surpass in sensorial properties. Such artisan products are increasingly appreciated because of their authenticity although of great consideration due to their variable microbiological and organoleptic quality. Overall monitoring of wildlife reservoir is needed in assessment its potential as sources for zoonosis agents exposures of humans as well as sources of bacterial strains relevant for enhancement and standardization of game meat sausages production. There are large variations in prevalence of microbial populations of game meat even within a single country and the published data for Croatia is limited and poorly documented which does not allow any related analysis. Especially the data on risk -based monitoring of zoonosis and antibiotic resistance genes transmission via game meat food chain in Croatia is missing and there is not authentic collection of indigenous bacterial strains that could act as a pool of novel genes and metabolic pathways relevant for high quality food production. MiCROgame focuses on the in situ diversity analysis as well as detailed characterization of lactic acid bacteria (LAB) isolated from traditional Croatian game meat sausages. Application of this autochthonous microbiota into the sausages production can influence the end-product quality and can accelerate maturation such helping producers to be more competitive on national or EU market. Special focus will be set towards identification and characterization of potential spoilage and pathogenic microflora and antibiotic resistance traits in order to estimate safety of locally produced game meat food and to identify sources of contamination. ]]></summary_en></project><project>
<id>2374</id><title_hr><![CDATA[Reforma računovodstva i financijskog izvještavanja kao sredstvo jačanja razvoja učinkovitog financijskog upravljanja u javnom sektoru RH]]></title_hr><title_en><![CDATA[Accounting and financial reporting reform as a means for strengthening the development of efficient public sector financial management in Croatia]]></title_en><user_id>7294</user_id><user_firstLast_name>VESNA  VAŠIČEK</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2013-11</proposal_call><code>IP-2013-11-8509</code><acronim><![CDATA[ACCFORPSFMINCRO]]></acronim><duration>20.08.2014 - 30.09.2018</duration><status>Završio</status><financ_value>55.443,06 eur</financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Ekonomija, </scie_field_hr><scie_field_en>Economy, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Ekonomski fakultet u Zagrebu]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Economics and Business]]></institution_en><team_members_id>7069, 7230, 7334, 7095, 7182, 7212, 7096, 7104, 2956, 19004, 19001, </team_members_id><team_members_names><![CDATA[Nives Botica Redmayne, SANJA BROZ TOMINAC, Verica Budimir, MARTINA DRAGIJA, Ivana Dražić Lutilsky, Maja Letica, MILENA PERŠIĆ, GORANA ROJE, Davor Vašiček, Tatjana  Jovanović, Jelena Poljasevic, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[Croatia, EU, public sector, accounting, financial reporting, accounting basis, IPSAS, financial management, asset management, cost management]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[The subject of the research addresses the need and ability to pursue budgetary accounting reform in Croatia, implying accrual accounting basis and International public sector accounting standards (IPSAS) implementation, with the aim to create quality accounting/financial reporting systems and sound financial management. Supporting that budgetary accounting reforms in Croatia are set as a necessity that arises from adjustments to comply with the EU regulations and the need for setting accounting system development in function of increasing the quality of accounting information as a basis for public management decision making, our research objectives broadly focus on: examining the possibilities for accruals and IPSAS appliance in Croatia, creation of public sector accounting (PSA) terminology framework, exploring the role of accounting in public sector asset management, examining the development of internal reporting system in the function of management decision making.Research objectives will be fulfilled through different activities, i.e.: exploring the adequacy of existing modified accrual basis model appliance and budgetary users’ financial statements qualitative characteristics comparison to the accruals appliance in chosen segments of the Croatian public sector; examining the level of Croatian budgetary accounting compliance with IPSAS on the path of international comparative studies on PSA harmonisation that would foster the creation of Croatian PSA terminology and interpretation on application of a selected number of IPSAS  in Croatian PSA content; developing the methodology for a comprehensive government asset recording in central asset register and whole government balance sheet; empirically assessing accounting information system from the standpoint of its’ upgrading with managerial and cost accounting elements, by developing and testing the applicable internal reporting model resulting in providing sound information for public management decision making. ]]></summary_en></project><project>
<id>2379</id><title_hr><![CDATA[Tekstilne antene za pametno okruženje]]></title_hr><title_en><![CDATA[Textile Antennas for Smart Environment]]></title_en><user_id>6555</user_id><user_firstLast_name>Davor Bonefačić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2013-11</proposal_call><code>IP-2013-11-6198</code><acronim><![CDATA[TexASE]]></acronim><duration>01.09.2014 - 31.08.2018</duration><status>Završio</status><financ_value>131.130,13 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Elektrotehnika, </scie_field_hr><scie_field_en>Electrical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id>6808, 6535, 4646, 5165, </team_members_id><team_members_names><![CDATA[Juraj Bartolić, Radovan Zentner, Željko Penava, Branimir Ivšić, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[antenna, textile antenna, wearable antenna, on-body communications, body-centric communications]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[The smart environment consists of wired and wireless network of communication devices and sensors which communicate between themselves and with humans, and enable safer, more pleasant and energy efficient environment adaptable to the change of conditions and tasks. Any wireless device needs an antenna as the interface between the electronic circuits and the free space. Wireless communication modules, sensors and RFID devices are integrated in common objects like clothes, home appliances, toys, consumables, etc. The used antennas must be small and unobtrusive, yet energy efficient. The aim of this project is to investigate new materials and techniques for antenna fabrication including conductive textiles and threads. A textile antenna integrated into clothes must be lightweight, flexible, and comfortable to wear, but still must keep good radiation properties. Textile antennas are very interesting for military personnel on the field as well as for rescue teams. Another important application is healthcare, where wireless sensors in real time monitor the patients&#39; health status and transmit data to the medical personnel. The broadest field of application of wearable antennas is in the entertainment and consumer electronics and mobile communications. Energy harvesting, and with it the associated antennas, can be used in all these fields to increase energy efficiency and enable operation of mobile devices. The aim of this project is to propose new and adapt existing antenna designs for integration into clothing and for new manufacturing techniques like embroidering or weaving. Another aspect to be considered in connection with wearable antennas is their operation in the proximity of human body which is a lossy dielectric. The second aim of this project is to study both theoretically and experimentally the propagation channel on the surface of the human body and off-body communications. The results will allow designing reliable on-body and off-body communication systems. ]]></summary_en></project><project>
<id>2381</id><title_hr><![CDATA[Utjecaj procesnih parametara na kinetiku heterogenih sustava koji se odvijaju u šaržnom reaktoru s miješanjem]]></title_hr><title_en><![CDATA[Impact of processing conditions on kinetics of heterogeneous systems in agitated batch reactors]]></title_en><user_id>422</user_id><user_firstLast_name>Nenad Kuzmanić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2013-11</proposal_call><code>IP-2013-11-8959</code><acronim><![CDATA[HETMIX]]></acronim><duration>01.09.2014 - 31.08.2018</duration><status>Završio</status><financ_value>122.748,69 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Kemijsko inženjerstvo, </scie_field_hr><scie_field_en>Chemical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Splitu, Kemijsko-tehnološki fakultet]]></institution_hr><institution_en><![CDATA[University of Split, Faculty of Chemistry and Technology]]></institution_en><team_members_id>6051, 3364, 6053, 4537, 6047, </team_members_id><team_members_names><![CDATA[Davor Rušić, Sandra Svilović, Marija Ćosić, Renato Stipišić, Antonija Kaćunić, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[heterogeneous process, batch reactor, process parameters, mixing, kinetics, crystallization, ion exchange, heavy metals, mathematical modeling]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[From engineering point of view, heterogeneous system can be categorized as very complex. The presence of multiple phases causes a series of limitations, primarily connected to transport phenomena and actually those limitations are the ones that cause their distinct kinetic determination. Due to the complexity and the wide range of heterogeneous processes, research would be limited to solid-liquid systems, taking place in agitated batch reactors. Two heterogeneous processes are to be investigated simultaneously, one that includes and one that excludes a chemical reaction (a. Batch cooling crystallization; b. Ion exchange of heavy metals). The base intention of the proposed project is to find a link between process parameters, hydrodynamic conditions in agitated batch reactor, process kinetics and characteristics of the final product (that is, final process result). Furthermore, the intention is to examine the mentioned relation as a function of reactor scale size as well. Considering the kinetic determination of the process, special attention will be given to the investigation of the influence of hydrodynamic conditions, i.e. the influence of the mixing operation in a batch reactor on the kinetics of the investigated processes. Since one of the goals of this project is to contribute to the theory of reactor design, experimentally obtained insights could represent the criteria basis of heterogeneous solid-liquid process equipment scale up as well as the basis for the mathematical modeling of the impact of operating conditions on the heterogeneous process result. This way the functional relations between studied variables would be established. ]]></summary_en></project><project>
<id>2384</id><title_hr><![CDATA[Višeskalni model betona s identifikacijom parametara]]></title_hr><title_en><![CDATA[Multi-scale concrete model with parameter identification]]></title_en><user_id>4072</user_id><user_firstLast_name>Ivica Kožar</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2013-11</proposal_call><code>IP-2013-11-9068</code><acronim><![CDATA[ConcreteMuScID]]></acronim><duration>01.09.2014 - 31.08.2018</duration><status>Završio</status><financ_value>128.741,12 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Građevinarstvo, </scie_field_hr><scie_field_en>Civil engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Građevinski fakultet u Rijeci]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Civil Engineering]]></institution_en><team_members_id>4673, 4880, 5624, 6013, 6135, 6912, 6843, 17853, </team_members_id><team_members_names><![CDATA[Gojko Balabanić, Joško Ožbolt, Boris Podobnik, Neira Torić Malić, Silvija Mrakovčić, Natalija Bede, Anamarija Perušić, Tea Rukavina, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[multi-scale, concrete, system identification, dynamic loading, computer model]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[In complex numerical models the calibration can only be achieved through interaction of measured data with the underlying mathematical model. Especially difficult situation occurs when loading is stochastic (e.g. wind, earthquake, traffic) since there is no direct relation between loading (input) and displacements (output).	System parameter identification will be based on inverse mathematical formulation so to present a reliable and theoretically sound procedure for identification of required parameters. One of the main goals of the system identification procedure is representative volume identification. It will be necessary to consider non-Gaussian stochastic processes with heavy tails characterizing dangerous rare events.	Regarding material parameters this project advocates the hypothesis that the fracture energy of a material is approximately constant and that the material constitutive law should not incorporate “rate effect”. The idea of (approximately) constant fracture energy for all loading rates is new and important in models of concrete under the dynamic loading. Also, the inclusion of the viscous parameter in the existing 3D microplane model for concrete is of vital importance for fatigue analysis since it connects creep and shrinkage (internal material loading) with dynamic loading (external structural loading).	In the end the developed concrete model will account for corrosion by coupling the mechanical properties of concrete and properties affecting the transport of humidity, oxygen and  chloride (chemo-hygro-thermo-mechanical model).	The calibration of the 3D model and its verification will be performed based on the simulation of the corresponding experimental tests from the laboratory and the available literature according to the procedure for system parameter identification described above.	Two main characteristics of the project: highly applicative and at the same time capable of producing high impact scientific results.]]></summary_en></project><project>
<id>2399</id><title_hr><![CDATA[Sekundarno stanovanje i socijalna održivost lokalnih zajednica u Hrvatskoj]]></title_hr><title_en><![CDATA[Second Homes and Social Sustainability of Local Communities in Croatia]]></title_en><user_id>6867</user_id><user_firstLast_name>Geran-Marko Miletić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2013-11</proposal_call><code>UIP-2013-11-1875</code><acronim><![CDATA[SHSSLCC]]></acronim><duration>01.06.2014 - 15.09.2017</duration><status>Završio</status><financ_value>32.751,68 eur</financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Sociologija, </scie_field_hr><scie_field_en>Sociology, </scie_field_en><institution_hr><![CDATA[Institut društvenih znanosti Ivo Pilar]]></institution_hr><institution_en><![CDATA[Institute of Social Sciences Ivo Pilar in Zagreb]]></institution_en><team_members_id>6323, 6317, 2541, 5688, 6024, 1220, 6746, 6092, 6603, 18985, 18979, 18980, 18981, 18982, 18983, 18984, </team_members_id><team_members_names><![CDATA[Anka Mišetić, Roko Mišetić, Krešimir Peračković, Saša Poljanec-Borić, Tomislav Smerić, Nenad Pokos, Sara Ursic, Mario Bara, Marica Marinović Golubić, Rašeljka Krnić, Srđana Urlić, Stanko Mirošević, Duje Radovniković, Mirjana Urlić, Katarina Mirošević, Boris Bučević, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[second homes, social sustainability, local communities, leisure, Croatia]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[The planned project starts from the premise that second home use, i.e. occasional use of dwellings for vacation and recreation, is a strong factor in socio-spatial transformation. There is a constant growth of this trend in Croatia, whereby certain areas, or to be more precise, the coastal area is more exposed to second homes expansion. This increase in pressure of second homes and the tendency of this phenomenon to change and take new forms, especially under the influence of the expected growth of international second homes and disappearance of the hierarchy in the use of dwellings, have directed the planned project towards one question: are second homes only an obstacle, or could they be a source of opportunities, i.e. an additional impulse to the social sustainability of local communities in Croatia. The main objectives of the project are: 1) Identifying settlements in Croatia with an increased number of second homes; 2) Determining types of settlements in Croatia, and getting an insight into the connection of second homes to relevant sociodemographic and socioeconomic features of the settlers; and 3) Analysing how second homes affect the daily life of the local community, social structures and processes in it. These objectives direct the research towards combining secondary analysis of the census data and the analysis of the empirical data gathered through case studies. This will enable a deep insight into the way second homes affect the local social reality. ]]></summary_en></project><project>
<id>2402</id><title_hr><![CDATA[Pretvorba ostataka poljoprivredne proizvodnje i energetskih kultura u energiju i proizvode dodane vrijednosti – proizvodnja bioulja i biougljena]]></title_hr><title_en><![CDATA[Converting waste agricultural biomass and dedicated crops into energy and added value products – bio-oil and biochar production]]></title_en><user_id>5589</user_id><user_firstLast_name>Tajana Krička</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2013-11</proposal_call><code>IP-2013-11-3328</code><acronim><![CDATA[AgBiomassConversion]]></acronim><duration>15.10.2014 - 14.10.2018</duration><status>Završio</status><financ_value>104.269,69 eur</financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Poljoprivreda, </scie_field_hr><scie_field_en>Agriculture, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Agronomski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Agriculture]]></institution_en><team_members_id>5606, 5600, 5604, 5608, 19075, 19643, </team_members_id><team_members_names><![CDATA[Neven Voća, Vanja Jurišić, Ana Matin, Nikola Bilandžija, Alan Antonović, Mateja Grubor, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[waste agricultural biomass, dedicated crops, conversion, pyrolysis, energy, added value products, bio-oil, biochar]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Biomass is one of the promising renewable energy resources and can be a partial alternate to fossil fuels. Common methods applied to make use of biomass energy potential are biochemical and thermochemical conversion methods. Pyrolysis is a thermo-chemical process carried out in the absence of oxygen that yields with three different end-products – bio-oil, biochar and syngas. Pyrolysis of agricultural residues can help meet renewable energy targets by displacing fossil fuels and, thereby, deal with concerns regarding the global warming. Unlike direct combustion, pyrolysis yields with more end-products. Bio-oil has environmental benefits as a clean fuel and causes less pollution as compared to fossil fuels, whereas biochar can be put on soil and act as a carbon-sequestering and climate-mitigating agent. Based on the above-mentioned, the overall objective of this project is to determine the potential of different types of biomass residues and waste, and dedicated crops, for bio-oil and biochar production via pyrolysis. Since the type of feedstock significantly influences the pyrolysis process and the yield of end-products, the specific objective of the proposed project will be to determine the potential of pyrolysis from different biomass feedstock collected in two climatically different regions, Mediterranean and Continental Croatia. Project will be split into three main phases, including feedstock collection and characterization, biomass pyrolysis, and end-products&#39; (bio-oil and biochar) characterization. This will provide the most detailed database so far, speaking worldwide, and should result with the information on the optimum feedstock, concerning the available biomass in relation to the region.]]></summary_en></project><project>
<id>2409</id><title_hr><![CDATA[Porezna politika i fiskalna konsolidacija u Hrvatskoj]]></title_hr><title_en><![CDATA[Tax Policy and Fiscal Consolidation in Croatia]]></title_en><user_id>82</user_id><user_firstLast_name>Helena Blažić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2013-11</proposal_call><code>IP-2013-11-8174</code><acronim><![CDATA[TPFCC]]></acronim><duration>01.06.2014 - 30.06.2018</duration><status>Završio</status><financ_value>36.827,92 eur</financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Ekonomija, </scie_field_hr><scie_field_en>Economy, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Ekonomski fakultet]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Economics and Business]]></institution_en><team_members_id>2759, 2716, 2754, 3265, 1250, 2822, 3555, 3370, 6318, 6361, 5230, </team_members_id><team_members_names><![CDATA[Maja Grdinić, Ana  Grdović Gnip, Maja Klun, Hrvoje Šimović, Ana Štambuk, Lejla Lazovic-Pita, Milan  Deskar-Škrbić, Bojana Olgić Draženović, Žiga Kotnik, Saša Drezgić, Mario  Pečarić, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[tax policy, tax system, tax structure, fiscal consolidation, Croatia]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[The project is dealing with a tax policy problem Croatia has been tackling with in times of its fiscal consolidation as to ensure enough fiscal revenues, support long-term growth and maintain and even increase the equity of the tax system. The research starts with an extensive expert opinion survey about the state and perspectives of Croatian tax systems, which will be extended to Slovenia and Bosnia and Herzegovina in order to do relevant cross analysis of the obtained results. This survey will be followed by some public attitude surveys concerning relevant tax issues.The macroeconomic effects of fiscal consolidation measures in Croatia, with the emphasis on tax measures, will be analyzed at different government levels as well as the effects of tax structure on the economic growth. The research will be broadened to encompass other (mostly region) countries.It is expected that the research team with their in-depth tax policy analyses will pinpoint different aspects of crucial tax policy issues in Croatia with problem-solving recommendations regarding financial transaction tax, real estate tax, environmental taxation, flat tax and some other base broadening and tax expenditure issues. ]]></summary_en></project><project>
<id>2414</id><title_hr><![CDATA[Likovna umjetnost i komunikacija moći u razdoblju ranoga novoga vijeka (1450.-1800.) : povijesne hrvatske regije na razmeđi Srednje Europe i Mediterana]]></title_hr><title_en><![CDATA[Visual Arts and Communication of Power in the Early Modern Period (1450-1800): Historical Croatian Regions at the Crossroads of Central Europe and the Mediterranean]]></title_en><user_id>1226</user_id><user_firstLast_name>Milan Pelc</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2013-11</proposal_call><code>IP-2013-11-6827</code><acronim><![CDATA[VACOP]]></acronim><duration>01.07.2014 - 30.06.2018</duration><status>Završio</status><financ_value>66.218,73 eur</financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Povijest umjetnosti, </scie_field_hr><scie_field_en>Art history, </scie_field_en><institution_hr><![CDATA[Institut za povijest umjetnosti]]></institution_hr><institution_en><![CDATA[Institute of Art History, Zagreb]]></institution_en><team_members_id>6665, 4903, 3408, 3742, 3481, 4586, 4663, </team_members_id><team_members_names><![CDATA[Josip Belamarić, Višnja Bralić, Daniel Premerl, Ivana Prijatelj Pavičić, Mirjana Repanić-Braun, Petra Batelja, Maja Žvorc, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[Art, Politics, Communication, Croatia, Early Modern period]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[This research will primarily focus on the analysis andinterpretation of the relation of pow er holders tow ard the visualarts in Croatian regions of the Early Modern Period, as w ell asthe places and the media of their transmission. In the spirit ofnew art history, the research w ill seek to answ er the follow ingquestions: 1. w hich media channels – including communicationmeans and strategies – did certain centres of pow er use tocreate and promote favourable responses among differenttypes of recipients in Croatia of the early modern period? 2.w hat w as the role of visual art in shaping public opinion and thesocial promotion and re(presentation) of pow er holders? Thepow er holders in Croatian regions w ho acted as artcommissioners w ere primarily from the ranks of the aristocracy(both secular and ecclesiastical) – representatives of the stateideologies of the Venetian Republic, the Kingdom of Hungary,the Habsburg Monarchy and the Dubrovnik Republic. In additionto them, there w ere also local corporate patrons and artcommissioners – confraternities – w hich mainly reflected theinterests of local communities. Those art commissioningchannels made possible cultural transfers in visual arts andarchitecture in the Croatian territory during the period from theearly Renaissance to the late Baroque. The research w illfacilitate the creation of a database containing relevant visualrecords of the aforementioned historical period, w hich w illenable a comparative analysis of the phenomenon from theperspective of the sociology of culture, critical iconology andsemiotics. Finally, this w ill result in the development of anappropriate model for the understanding and interpretation ofthe specific usage of visual arts as mediator in thecommunication of pow er in Croatia of 1450-1800.]]></summary_en></project><project>
<id>2420</id><title_hr><![CDATA[Novi koncept primijenjene kognitivne robotike u kliničkoj neuroznanosti]]></title_hr><title_en><![CDATA[A new concept of Applied Cognitive RObotics in clinical Neuroscience]]></title_en><user_id>7302</user_id><user_firstLast_name>Bojan Jerbić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2013-11</proposal_call><code>IP-2013-11-4192</code><acronim><![CDATA[ACRON]]></acronim><duration>01.09.2014 - 31.08.2018</duration><status>Završio</status><financ_value>124.228,55 eur</financ_value><scie_area_hr>Tehničke znanosti, Biomedicina i zdravstvo, </scie_area_hr><scie_area_en>Technological sciences, Biomedicine and health sciences, </scie_area_en><scie_field_hr>Strojarstvo, </scie_field_hr><scie_field_en>Mechnical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet strojarstva i brodogradnje]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Mechanical Engineering and Naval Architecture]]></institution_en><team_members_id>7303, 3760, 7444, 7454, 7453, 7448, 7450, 7555, 7311, 7582, 7611, 17378, 22645, </team_members_id><team_members_names><![CDATA[Darko Chudy, Gojko Nikolić, Tomislav Stipančić, Filip  Šuligoj, Petar Ćurković, Marko Švaco, Bojan Šekoranja, vedran deletis, Dominik Romić, Gordan Grahovac, Domagoj Dlaka, Vladimira Vuletic, Josip Vidaković, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[robotics, artificial intelligence, cognitive models, medicine, neuroscience]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[The research in this project leads to novel forms and uses of cognitive robotics applied in clinical neuroscience. Robot’s performances during the surgical procedures are investigated within the previously conducted technological project, RONNA - Robotic Neurosurgical Navigation. Results of RONNA suggest that the benefits of using robots in the operating room are enormous, e.g. increased accuracy and repeatability of the surgical procedures, flexible and tremor free operations, etc. During the RONNA realisation, it is recognized that certain new cognitive robot skills yet need to be developed.The long-term vision of the proposed ACRON project as a multi-disciplinary research arises from the recognition that a paradigm shift in human-robot-environment interaction is needed. Currently, technology robustness is achieved by restricting the interaction space, so that the region and the nature of the interaction can be controlled by the system. In ACRON, the cognitive fulcrum will therefore move from sensed data to the robot contextual anticipation.ACRON will advance the research providing a uniform scientific framework for the study, development and implementation of cognitive concepts, providing the robot to function in ICT enabled ubiquitous environment that can be shared by different kinds of agents. ACRON will therefore bring the new context-aware medical robot capable to anticipate the most appropriate actions respecting the phase of the medical procedure and spatial positions of the staff and objects. We will investigate the relationship between people, robots and the shared environment where they interact and work together. By moving throughout the discretized working space and while achieving the current assignment, the medical robot will become able to avoid all-possible spatial collisions and make the appropriate context-based decisions.]]></summary_en></project><project>
<id>2432</id><title_hr><![CDATA[Uspostavni istraživački projekti o društvenom poduzetništvu]]></title_hr><title_en><![CDATA[Installation Project for REsearch about Social ENTrepreneurship]]></title_en><user_id>4514</user_id><user_firstLast_name>dražen šimleša</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2013-11</proposal_call><code>UIP-2013-11-5332</code><acronim><![CDATA[iPRESENT]]></acronim><duration>15.09.2014 - 01.03.2018</duration><status>Završio</status><financ_value>49.880,38 eur</financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Sociologija, </scie_field_hr><scie_field_en>Sociology, </scie_field_en><institution_hr><![CDATA[Institut društvenih znanosti Ivo Pilar]]></institution_hr><institution_en><![CDATA[Institute of Social Sciences Ivo Pilar in Zagreb]]></institution_en><team_members_id>6323, 4720, 7578, 21224, </team_members_id><team_members_names><![CDATA[Anka Mišetić, Filip Majetić, Jelena Puđak, Anita Bušljeta Tonković, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[social entrepreneurship, sustainability, social benefits, responsible, business model]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[The main goal of iPRESENT (Installation Project for REsearch about Social ENTrepreneurship) project is to research capacities and potentials of social entrepreneurship as an environmentally friendly and socially responsible business model in Croatia. Social Entrepreneurship is one of the leading and growing phenomena, it has outcomes in social, economic and environmental fields, and as such is suitable and studious for scientific research. This is especially the case in a country such as Croatia, with longstanding economic crisis, rise of unemployment; decrease of social rights and trust, but at the same time quite a wealth of natural resources and tradition in cooperative business models. The project has a specific objective to initiate and secure long term scientific base and data for research on social entrepreneurship in Croatia; to set up a relevant and up to date published materials about social entrepreneurship open to science community and public; to test the level of 3BL (Triple bottom line) in social enterprises in Croatia; and to prepare guidelines and “advice book” for potential social entrepreneurs and recommendations for important and interested stakeholders. Through the three years of project duration, an already experienced scientist and researchers with young colleagues will explore and define the concept of social entrepreneurship, compare and elaborate EU perspectives and conditions regarding the subject of the project, but also place considerable emphasis on methodological approach that should provide us with reliable and operable scientific data. The project consists of a balanced and well suited mix of qualitative and quantitative scientific methods depending on applicability and specific needs within the project.It is worth mentioning that this is the first time in Croatia that the scientific community recognised social entrepreneurship as a valuable subject for long-term analytical work and research.]]></summary_en></project><project>
<id>2441</id><title_hr><![CDATA[Mjerenje, modliranje i prognoziranje volatilnosti]]></title_hr><title_en><![CDATA[Volatility measurement, modelling and forecasting]]></title_en><user_id>7589</user_id><user_firstLast_name>Josip Arnerić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2013-11</proposal_call><code>UIP-2013-11-5199</code><acronim><![CDATA[Volatility]]></acronim><duration>01.09.2014 - 31.08.2017</duration><status>Završio</status><financ_value>36.519,80 eur</financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Ekonomija, </scie_field_hr><scie_field_en>Economy, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Ekonomski fakultet u Zagrebu]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Economics and Business]]></institution_en><team_members_id>3912, 4299, 4342, 6252, 4385, 4833, 21323, </team_members_id><team_members_names><![CDATA[Blanka Škrabić Perić, Mirjana Čižmešija, Tea Poklepović, Ivana Lolić, Petar Sorić, Zdravka Aljinović, Danijel Mlinarić, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[OHLC volatility estimator, GARCH switching model, news impact curve, panel-GARCH models, high-frequency data, neural-networks, quasi-Newton algorithm]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Volatility of financial time series has become a key input to many important finance applications such as investment, portfolio selection and allocation, option pricing, hedging and risk management. The importance of accurate volatility estimates has become even more significant after the financial crisis. As volatility itself is not observable variable, many different volatility estimators have emerged in the literature to address this problem. This project proposal will explore some of methodologically complexities of volatility modelling and forecasting with respect to both the parametric and nonparametric approaches. Moreover, one of the objectives is to investigate news impact curve of different volatility models as well as to compare different types of Generalized Autoregressive Conditional Heteroscedascity models in terms of their ability to describe structural changes in returns and to explore if Markov regime switching GARCH models outperform uni-regime GARCH models in forecasting volatility when sudden switching occurs. According to previous commonly used aspects of volatility measurement and modelling, two relatively new approaches will be explored. First one relies on neural-networks as econometric tool. The second one combines panel methodology with GARCH models. It should be emphasized that new OHLC volatility estimator will be defined as the most efficient one when high frequency data is not available. The main contribution is to train doctoral and postdoctoral students within interdisciplinary areas of statistics, econometrics, financial econometrics, mathematics, operational research and their applications.]]></summary_en></project><project>
<id>2445</id><title_hr><![CDATA[Hijerarhijska konsolidacija velikih potrošača temeljena na upravljanju za integraciju u napredne mreže]]></title_hr><title_en><![CDATA[Control-based Hierarchical Consolidation of Large Consumers for Integration in Smart Grids]]></title_en><user_id>7612</user_id><user_firstLast_name>Mario Vašak</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2013-11</proposal_call><code>UIP-2013-11-6731</code><acronim><![CDATA[3CON]]></acronim><duration>01.12.2014 - 30.11.2017</duration><status>Završio</status><financ_value>132.722,81 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Elektrotehnika, </scie_field_hr><scie_field_en>Electrical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id>7616, 7618, 7624, 17458, 17455, 19265, 19325, </team_members_id><team_members_names><![CDATA[Vinko Lešić, Mato Baotić, Nedjeljko  Perić, Hrvoje  Novak, Marko Gulin, Anita Martinčević, Antonio Starčić, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[optimal control, hierarchical control, building, railway traffic system, energy consumption, power flow optimisation, prosumer, smart grid]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Buildings and railway traffic systems are examples of complex technical systems that consume significant energy amounts so as to enable their inner processes to evolve as required. Thereby the requirements on dynamic functioning of these systems can be achieved by different system interactions, whereas some of them are more preferable than the others from the standpoints of energy consumption or other criteria like price of operation or equivalent pollution.The global objective of the project 3CON is to research and develop optimal control techniques on significantly different large consumers – building systems and railway traffic systems – in conceptually identical way: by applying the principle of hierarchical decomposition of systems and cooperative optimal controls between the hierarchy levels. In that way the computed energy consumption profile on the lower level directly maximizes the global economic gain of the system operation in the presence of system constraints (e.g. allowed temperatures or fixed train travelling time). This will enable the proactive role of these largest consumers in energy grids of the future (smart grids). It will make them responsive and in position to best exploit the imposed varying energy exchange terms. Thereby vast possibilities in energy grid management through dynamic pricing will be opened – foremost for reducing losses between generation and consumption points in the grid and increasing grid reliability. The secondary global objective of this installation grant is to build an internationally competent research group in control of energy-intensive systems on the Faculty which is also recognized and accepted by relevant domestic companies.The project developments will be verified through building and railway traffic case studies that will be supervised by relevant Croatian companies. This will ensure that all relevant system issues are taken care of in the design and that the design itself is close to exploitation.]]></summary_en></project><project>
<id>2446</id><title_hr><![CDATA[Infektomika humanih jetrenih neparenhimskih stanica u kroničnom hepatitisu C]]></title_hr><title_en><![CDATA[Infectomics Study of Human Liver Non-parenchymal Cells in Chronic Hepatitis C]]></title_en><user_id>6975</user_id><user_firstLast_name>Adriana Vince</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2013-11</proposal_call><code>IP-2013-11-4241</code><acronim><![CDATA[ILHNCHC]]></acronim><duration>01.07.2014 - 31.05.2019</duration><status>Završio</status><financ_value>132.722,81 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Ništa od navedenog]]></institution_hr><institution_en><![CDATA[Nothing from this list]]></institution_en><team_members_id>3952, 3951, 7271, 3443, 7295, 7391, </team_members_id><team_members_names><![CDATA[Lana Gorenec, Ivana Grgić, Ivan  Kurelac, Neven Papić, Davorka Dušek, Tajana Filipec Kanižaj, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[HCV, gene expression, Kupffer cells, LSEC, inflammation, immunotolerance  ]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Hepatitis C virus (HCV) is the leading cause of liver disease. HCV productively infects hepatocytes to impart liver inflammation and progressive tissue damage leading to fibrosis and cirrhosis. These processes underlie liver dysfunction and are thought to drive the onset of liver cancer. However, the molecular mechanism(s) by which HCV confers hepatic inflammation are not defined. Now, there is growing evidence that liver sinusoidal endothelial cells (LSEC) and Kupffer cells (KC), may play key roles in regulating immune responses and facilitating tolerance induction. These cells are playing a pivotal role in blood-borne virus clearance (>90%), leaving only a small fraction of infectious virus that escapes clearance in a manner peculiar to each individual pathogen. The biology of HCV, specifically regarding non-parenchymal liver cells, has been largely neglected. LSEC account for the 20% and KC for 15% of the hepatic cells, and are a unique organ-resident cell population with diverse functions, including degradation of bacterial by-products, antigen presentation and induction of tolerance. The hypothesis of the research is that HCV infection reprograms cellular gene expression of LSEC and KC, which results in the modulation of the inflammatory responses. Applying the infectomics approach, we plan to perform a series of next-generation sequencing experiments on LSEC and KC isolated and purified from healthy, mild and severe chronic hepatitis C liver biopsies. This will allow us to detect expression changes related with disease progression. Selected candidate genes will be comprehensively studied in in vitro systems in order to elucidate their role in modulation of inflammatory and adaptive immune responses. Through the development of this project it is expected that a series of high impact results will be obtained, which will facilitate the development of more significant biomarkers and effective interventions against HCV infection.]]></summary_en></project><project>
<id>2447</id><title_hr><![CDATA[Komunikacije usmjerene čovjeku u pametnim mrežama]]></title_hr><title_en><![CDATA[Human-centric Communications in Smart Networks]]></title_en><user_id>932</user_id><user_firstLast_name>Maja Matijašević</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2013-11</proposal_call><code>IP-2013-11-8065</code><acronim><![CDATA[HUTS]]></acronim><duration>01.10.2014 - 30.09.2017</duration><status>Završio</status><financ_value>99.542,11 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Elektrotehnika, </scie_field_hr><scie_field_en>Electrical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id>2717, 2626, 2628, 2612, 4930, 5079, 2706, 2572, 2770, 2775, 4895, 6720, 6608, 2785, 5345, 5033, 5339, 17866, </team_members_id><team_members_names><![CDATA[Ignac Lovrek, Igor Sunday Pandžić, Zeljka Car, Gordan Ježić, Mario Kušek, Ivana Podnar Žarko, Krešimir Pripužić, Ognjen Dobrijević, Tomislav Grgić, Mirko Sužnjević, Marin Vuković, Aleksandar Antonić, Šimo Brtan, Krunoslav Ivešić, Damjan Katušić, Nenad Markuš, Pavle Skočir, Martina Marjanović, ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[smart network, big data, cloud communications, human computer interface, internet of things]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Human-centric Communications in Smart Networks (HUTS) project will address open questions regarding smart networks and human-centric communication in which data is both gathered from – and provided to – humans, anywhere and at any time, responding to their current needs. Through its research objectives, the project will investigate networking aspects of human-centric communication, such as the allocation and optimization of cloud and network resources and also providing related quality of service guarantees. This research will be used as a building block for various smart services, which enable user and device adaptation based on learning from previous situations and communicating the results of these situations. This powerful concept relies on new methods in cloud computing for big data processing and Internet-connected objects, such as smart sensors and actuators, as well machine-to-machine communication between devices using self-organizing ad-hoc networks. Smart services are further built upon innovative complex-service composition methodology and intelligent mechanisms to be formulated by the project. The introduction of smart services will drive the changes in the way people interact with devices towards more intuitive and unconstrained means. In particular, contactless user interaction, considering various categories of users, and networked virtual worlds/environments will be studied. Network data traffic models and network management will be proposed, including online charging mechanisms for dynamic pricing and cost calculation of smart services. The research proposed in this project will create new knowledge, strengthen research mentoring and improve young scientist capacities in Croatia, contribute results to science in the area of Information and Communication Technology, and help develop Croatian scientific and research space as one of the long-term strategic priorities, enabling knowledge transfer to Croatian economy for the benefit of society.]]></summary_en></project><project>
<id>2464</id><title_hr><![CDATA[Jako korelirani elektroni u slojnim organskim materijalima i manganitima: niskofrekventna pobuđenja i nelinearna dinamika]]></title_hr><title_en><![CDATA[]]></title_en><user_id>2708</user_id><user_firstLast_name>Mario Basletić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2014-06</proposal_call><code>DOK-2014-06-6358</code><acronim><![CDATA[SCEinLOM]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, </scie_field_hr><scie_field_en>Physics, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>17776</team_members_id><team_members_names><![CDATA[ Doktorand: Branimir Mihaljević ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[correlated electrons, unconventional superconductivity, colossal magnetoresistance, charge and spin orderings, quantum spin liquids, nonlinear effects]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Strongly correlated electrons in solids generate broken symmetry phases and collective excitations that are fundamental to our understanding of the most intriguing properties of quantum matter. Phase diagrams of layered cuprate, organic superconductors and manganites, as well as some other transition-metal systems, famous for the phenomena of unconventional superconductivity (SC) and colossal magnetoresistance (CMR), respectively feature an extraordinary complexity of electronic phases, which can be tuned by chemical composition, magnetic field and pressure. A prominent place among these phases is held by stripes, patterns of charge order (CO), which are thought to be linked to SC and CMR, as well as by CO phases with ferroelectric signatures due to a rich variety of nonlinear properties and complex dynamics. Despite intense research efforts, these basic issues in condensed matter physics bear many open questions. We propose to investigate the nature of charge/spin-ordered phases and their motion developed in series of organic and transition metal solids applying modern experimental tools available at the Institute of Physics, Zagreb and at the Department of Physics, Faculty of Science, University of Zagreb (dielectric spectroscopy, pulsed nonlinear conductivity, ac/dc resistance, magnetoresistance and Hall effect).  Our overall contributions to the field and our expertise in condensed matter physics have been internationally recognized. Together with the available experimental means, this positions us as researchers fully suitable and competent for the proposed task. Our international partners will give an added value with samples, experiments and expertise in the terahertz and infrared spectroscopy. Integrated students and postdocs are going to acquire advanced skills in the materials science and learn to solve complex problems in a collaborative environment. Results will be published in international scientific journals and presented at international conferences.]]></summary_en></project><project>
<id>2465</id><title_hr><![CDATA[Liječenje neuropatske boli stimulacijom spinalnog ganglija]]></title_hr><title_en><![CDATA[]]></title_en><user_id>4000</user_id><user_firstLast_name>Damir Sapunar</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2014-06</proposal_call><code>DOK-2014-06-5195</code><acronim><![CDATA[NeuroMod]]></acronim><duration>08.01.2015 - 06.02.2025</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Splitu, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Split School of Medicine]]></institution_en><team_members_id>17768</team_members_id><team_members_names><![CDATA[ Doktorand: Tihana Repić ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[neuropathic pain, nerve injury, neuromodulation, dorsal root ganglion, ganglionic field stimulation, T-junction, microelectrode arrays]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Neuropathic pain is a debilitating disease of the somatosensory system that has a huge socio-economic impact. Numerous studies, including those from our laboratory have established that the injured dorsal root ganglion (DRG) is the important site for pathophysiologic changes that lead to development of neuropathic pain. Although DRG neurons are critical for the onset of neuropathic pain, there are no relevant clinical treatments for neuropathic pain that target this organ. With this proposal we aim to prove that neurostimulation techniques can be successfully used to manipulate neuronal function at the level of experimentally injured DRGs. In order to test this hypothesis we will construct a fully implantable neuronal stimulator for freely moving rats, devise an implantation technique and define stimulation protocols. This stimulator will be tested in rats with two types of experimentally induced nerve injury; spinal nerve ligation and carrageenan-induced inflammation model. Since this invasive procedure bears substantial risk of inflammation and other adverse neural tissue response, which can induce pain per se, we will also investigate connective tissue fibrosis and neuroinflammatory response in neural tissue of DRG and dorsal horn. The effect of the stimulation on excitability of injured DRG neurons will also be tested in vitro. Our last aim builds on our previous study in which we showed that neuronal injury may disable T-junction filtering and thereby increase the net conduction of afferent traffic. With this proposal we will test whether stimulation can modulate filtering properties of DRG T-junction. This will be addressed using recordings from injured sensory neurons of dorsal root ganglia excised from adult rats, and recently developed methodology that will allow us to electrically visualize action potential propagation in DRG neurons grown over custom microelectrode arrays.]]></summary_en></project><project>
<id>2466</id><title_hr><![CDATA[Diofantove m-torke, eliptičke krivulje, Thueove i indeksne jednadžbe]]></title_hr><title_en><![CDATA[]]></title_en><user_id>1262</user_id><user_firstLast_name>Alan Filipin</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2014-06</proposal_call><code>DOK-2014-06-9078</code><acronim><![CDATA[DIOPHANTINE]]></acronim><duration></duration><status>Prekinut</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Matematika, </scie_field_hr><scie_field_en>Mathematics, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Građevinski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Civil Engineering]]></institution_en><team_members_id>17746</team_members_id><team_members_names><![CDATA[ Doktorand: Marija Bliznac ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[Diophantine equations, elliptic curves, Diophantine approximations, polynomials, cryptography]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[The proposed project will coordinate and support research activities of Croatian number theory group. One of the main topics of research in this project will be Diophantine m-tuples (sets with the property that the product of its any two distinct elements increased by 1 is a perfect square) and their generalizations. The first Diophantine quadruple {1,3,8,120} was found by Fermat. Baker and Davenport proved that Fermat&#39;s set cannot be extended to a quintuple. This result motivated the famous conjecture that there does not exist a Diophantine quintuple. Dujella proved that there does not exist a Diophantine sextuple and that there are only finitely many Diophantine quintuples. Recently, Filipin, Fujita and Elsholtz significantly improved previously known upper bounds for the number of Diophantine quintuples, but the main conjecture still remains open. Various generalizations of Diophantine m-tuples will be studied, in particular, considering the problem in the rings of integers of number fields of small degree.  Diophantine triples were used by Dujella in construction of high-rank elliptic curves over Q and Q(T) and new results in that direction are expected. In determining exactly the Mordell-Weil group of several elliptic curves over Q(T), an important tool is recent algorithm by Gusić and Tadić for finding rationals at which the specialization map is injective. We plan to improve and extend this algorithm for elliptic curves over K(T) for general number fields K. Members of the group will also work on Thue, Thue-Mahler and index forms equations, problems related to sums of divisors, polynomial root separation and applications of Diophantine approximations to cryptanalysis. The results of the research will be published in respectable journals and presented on international conferences. Through this project we will intensify our scientific connections with international number-theorists and qualify young researchers for scientific research in number theory.]]></summary_en></project><project>
<id>2468</id><title_hr><![CDATA[Uloga miRNA u infekciji i patogenezi herpes simplex virusa 1]]></title_hr><title_en><![CDATA[]]></title_en><user_id>43</user_id><user_firstLast_name>Igor Jurak</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2014-06</proposal_call><code>DOK-2014-06-3295</code><acronim><![CDATA[]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Biologija, </scie_field_hr><scie_field_en>Biology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Fakultet biotehnologije i razvoja lijekova]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Biotechnology and Drug Development]]></institution_en><team_members_id>17801</team_members_id><team_members_names><![CDATA[ Doktorand: Marina Matešić ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>2470</id><title_hr><![CDATA[Algebarske i kombinatorne metode u teoriji verteks algebri]]></title_hr><title_en><![CDATA[]]></title_en><user_id>92</user_id><user_firstLast_name>Dražen Adamović</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2014-06</proposal_call><code>DOK-2014-06-4322</code><acronim><![CDATA[ACMVAT]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Matematika, </scie_field_hr><scie_field_en>Mathematics, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>17775</team_members_id><team_members_names><![CDATA[ Doktorand: Ana Kontrec ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[vertex algebras, W-algebras,  affine  Lie algebras, logarithmic  CFT, combinatorial bases,  Zhu&#39;s algebras, C2 cofiniteness,]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[In the proposed project we shall study the representation theory of important classes of vertex algebras with particular emphasis on the theory of vertex algebras with origins  in physics. We shall also study the affine vertex algebras and their connections with W-algebras. Based on previous research of D. Adamović and O. Perše from the papers J. Algebra 319 (2008); SIGMA 8 (2012); Algebras and Representation Theory 16 (2013) we shall apply the representation theory of vertex algebras of affine type   to the structure and representation theory of W-algebras. In the last few years, C2-cofinite, irrational vertex algebras with non-semisimple representation categories attracted a lot of interest. Such vertex algebras also appear in the logarithmic conformal field theory. By using methods developed in the papers by  D. Adamović and  A. Milas: Adv. Math. 217 (2008), Comm. Math. Phys. 288 (2009),  Adv. Math. 227 (2011)  and  J. Math. Phys. 73511 (2012) we shall study the representation theory of certain irrational, C2-cofinite vertex algebras and their connections with the theory of quantum groups. An emphasis will be put on the tensor categories of modules of C2-cofinite vertex algebras, the determination of fusion rules, orbifold vertex subalgebras and the explicit realization of logarithmic representations.  A part of the research will be devoted to some combinatorial aspects of the  representation theory of affine Kac-Moody Lie algebras. We will study  the application of intertwining operators   on the determination of   combinatorial bases of Feigin-Stoyanovsky type subspace and the associated fermionic character formulas developed by M. Primc and  collaborators. We also plan to apply the above methods on the combinatorial structures related to triplet vertex algebras and logarithmic CFT.]]></summary_en></project><project>
<id>2472</id><title_hr><![CDATA[Lokalna proba i mezoskopska dinamika u novim fazama jako koreliranih elektronskih sustava]]></title_hr><title_en><![CDATA[]]></title_en><user_id>50</user_id><user_firstLast_name>Miroslav Požek</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2014-06</proposal_call><code>DOK-2014-06-9935</code><acronim><![CDATA[LOMEDY]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, </scie_field_hr><scie_field_en>Physics, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>17735</team_members_id><team_members_names><![CDATA[ Doktorand: Marija Došlić ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[nuclear magnetic resonance, microwaves, cuprates, pnictides, frustrated spin systems, charge order]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Investigations of strongly correlated electron systems (SCES) attract an ever-growing scientific community, not only because of high potential for new technological applications, but also as a virtually unfailing source of new basic phenomena and theoretical concepts. The properties of such systems can be described only by taking into account collective phenomena governed by strong and competing interactions, often leading to frustrations. The subtle interplay of interactions is, in turn, a key ingredient for extraordinary complex phase diagrams exhibited by SCES. Even more interesting are regions of instabilities away from stable phases.The way a new phase emerges close to a phase boundary reveals hidden properties of the studied system. It is extremely important to understand how symmetry breaks in the transition itself and identify the space and time-scales relevant for the changes of order parameter within the transition. Sometimes an intermediate state emerges between two stable phases, bringing new physics to light. This project aims to study some of these new, mostly unexplored states that emerge between well explored stable phases in SCES, or as a consequence of some kind of frustration. In order to obtain a complete picture of new states of matter we will combine several advanced experimental methods: nuclear magnetic and quadrupolar resonance (NMR and NQR) as an atomic-scale, local probe, and nonlinear conductivity as a mesoscopic probe of electronic physics. We will be able to systematically study the many phases and transitions in SCES, provide answers to some currently burning questions, and significantly advance our knowledge about them. In particular, we will study charge order in novel superconductors, and spin liquid and spin nematic states in frustrated quantum spin systems.The project will fully employ the new broadband NMR laboratory in Zagreb, strengthen its visibility and international collaborations, and enable finishing of three PhD theses.]]></summary_en></project><project>
<id>2473</id><title_hr><![CDATA[Sloboda volje, uzročnost i slučaj]]></title_hr><title_en><![CDATA[]]></title_en><user_id>242</user_id><user_firstLast_name>Filip Grgić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2014-06</proposal_call><code>DOK-2014-06-7408</code><acronim><![CDATA[FreeWilL]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Filozofija, </scie_field_hr><scie_field_en>Philosophy, </scie_field_en><institution_hr><![CDATA[Institut za filozofiju]]></institution_hr><institution_en><![CDATA[Institute for Philosophy in Zagreb]]></institution_en><team_members_id>17854</team_members_id><team_members_names><![CDATA[ Doktorand: Anna Kocsis ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[free will, causality, luck, determinism, compatibilism, moral responsibility, consciousness]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[The overall goal of our research is to contribute to our deeper understanding of what is involved in having and experiencing free will by offering some new insights and arguments in the pertaining areas. The more specific goal of our project is to produce original contributions in some central areas of research into free will, in the following disciplines: metaphysics, philosophy of mind, ethics, history of philosophy, philosophy of physics, as well in philosophical interpretations of relevant results of psychology and neuroscience. The most specific goals of the research are the following. First, we plan to show that deterministic threats to free will are surmountable. Second, we plan to show that indeterministic threats (i.e. those based on randomness and luck) are also surmountable. Third, we will argue that some problems with compatibilistic accounts are more serious than has hitherto been recognized. This is due, first, to the fact that, in our opinion, compatibilism is also susceptible to a specific luck objection, and second, to the fact that it is sometimes based on insufficiently clear notions of causality, determinism and natural laws. Fourth, we will argue that Aristotelian version of compatibilism can bring some fresh light to contemporary discussions, but that it is also susceptible to a specific luck objection.Research activities can be grouped under five main headings: 1. Causality, laws of nature and luck (1.1. Causality, laws of nature and action; 1.2. Indeterminism and luck; 1.3. The varieties of determinism), 2. Brain, mind and agency (2.1. Freedom and consciousness, 2.2. Mental causation and ascriptions of intentionality, 2.3. Some perspectives from neuroscience), 3. Moral responsibility (3.1. Principle of Alternative Possibilities, 3.2. Bioenhancement and responsibility), 4. Aristotelian perspective (4.1. Aristotle’s compatibilism, 4.2. Aristotle on moral responsibility and luck), 5. Free will, determinism and the quantum rescue.]]></summary_en></project><project>
<id>2474</id><title_hr><![CDATA[Napredni tekstilni materijali dobiveni ciljanom modifikacijom površine]]></title_hr><title_en><![CDATA[]]></title_en><user_id>747</user_id><user_firstLast_name>Sandra Bischof</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2014-06</proposal_call><code>DOK-2014-06-5072</code><acronim><![CDATA[ADVANCETEX]]></acronim><duration></duration><status>Prekinut</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Tekstilna tehnologija, </scie_field_hr><scie_field_en>Textile technology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Tekstilno-tehnološki fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Textile Technology]]></institution_en><team_members_id>17700</team_members_id><team_members_names><![CDATA[ Doktorand: Iva Matijević ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[advanced materials, textiles, surface modification, fibre reinforced composites, nano-metal particles, LCA, ]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[The demand for advanced textile materials has dramatically increased during the last few decades, in particular for engineering, medical and technical applications. A new sight proposed by this project is in the merging of so far separate research teams involved in the development of advanced textile materials, through targeted eco-driven surface modifications. Surface pre-treatments and modification will be carried out on selected sustainable textile materials, using environmentally friendly substances and processes, in order to attain antimicrobial, flame retardant, oil/hydrophobic, wellness or medical properties obtaining high added value textiles. Different environmentally friendly methods of microwave, ultrasound or plasma modification processes will be used to enhance targeted functionalities as well as to increase interfacial adhesion between fibres and polymer matrix in fibre reinforced composites. The other approach of the production of highly active surfaces which will have capability to block UV and microwave radiation, enhance oil and water repellence, antimicrobial, self-cleaning, and flame retardant properties is in the application of micro/nano-particles such as TiO2, ZnO, Cu, Ag and Au. These particles can be applied on the surface of fibers, textiles, clothing or inlayers for footwear. Detailed characterization of each treatment effectiveness, so as their effect on humans and the environment will be investigated. Laundering durability and maintenance properties are equally important as the effectiveness of developed advanced material. Introduction of novel eco-driven surface modification processes in textile production will be complemented by the risk analysis and sustainability issues, focusing onto production and product safety, usage and recyclability of newly developed product without significant environmental burden. Innovative textile products will be directed towards the needs of the textile, chemical, pharmaceutical or medical industries. ]]></summary_en></project><project>
<id>2475</id><title_hr><![CDATA[Istraživanje utjecaja na okoliš primjene nanomaterijala u pročišćavanju voda]]></title_hr><title_en><![CDATA[]]></title_en><user_id>984</user_id><user_firstLast_name>Hrvoje Kušić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2014-06</proposal_call><code>DOK-2014-06-2343</code><acronim><![CDATA[NanoWaP]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Kemijsko inženjerstvo, </scie_field_hr><scie_field_en>Chemical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet kemijskog inženjerstva i tehnologije]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Chemical Engineering and Technology]]></institution_en><team_members_id>17765</team_members_id><team_members_names><![CDATA[ Doktorand: Marin Kovačić ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[Water treatment, Advanced oxidation technologies, Photocatalysis, Pharmaceuticals degradation, Nanocomposites, Toxicity]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[The water resources globally are facing tremendous pressures due to increased consumption and pollution caused by growing population and industrialization. Thus, the development of advanced treatment technologies is highly required. Technologies using nanomaterials are one of the fast-growing fields creating variety of new commercial nanoparticles. One of the innovative applications of nanomaterials with a great potential involve their usage as water treatment tools. The photocatalytic treatment using nano-TiO2 as a destructive and “zero” waste method for water purification provides a synergy of advanced oxidation technologies and nanomaterials application with a great potential to be commercialized. However, some features of TiO2 photocatalysis, its mechanical and chemical stability, have to be improved to minimize the potential negative implications.The main goal of NanoWaP project is to develop the sustainable photo-AOT with nanocomposite photocatalysts for the purification of water containing pharmaceuticals. In order to overcome the limitations of nano-TiO2 technologies: agglomeration tendency, post-separation, low activation potential under the sunlight, novel nano-TiO2-based composites with iron-exchanged zeolites and SnS2 will be investigated for degradation of pharmaceuticals in water. The efficiency will be evaluated using an innovative integral approach including: (i) pharmaceuticals removal expressed in a terms of common ecological parameters, (ii) energy consumption per decreased concentration of chosen ecological parameter for one order of magnitude, and (iii) the assessment of adverse environmental effects. Besides, the photocatalysts characterization prior and after the treatment would provide an additional insight in its stability which will be also examined through consecutive runs.]]></summary_en></project><project>
<id>2476</id><title_hr><![CDATA[Očuvanje mikrobne raznolikosti povezane s proizvodnjom tradicionalnih hrvatskih kobasica od mesa  divljači: biotehnološka i sigurnosna karakterizacija]]></title_hr><title_en><![CDATA[]]></title_en><user_id>4884</user_id><user_firstLast_name>Mirna Mrkonjić Fuka</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2014-06</proposal_call><code>DOK-2014-06-5664</code><acronim><![CDATA[miCROgame]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Poljoprivreda, </scie_field_hr><scie_field_en>Agriculture, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Agronomski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Agriculture]]></institution_en><team_members_id>17813</team_members_id><team_members_names><![CDATA[ Doktorand: Ana Žgomba Maksimović ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[traditional game meat sausages, lactic acid bacteria, foodborn pathogens, antibiotic resistance, starter cultures]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Despite the fact that nowadays the utilization of starter cultures is a prerequisite for the meat industry, as product reproducibility, reduction of fermentation times and enhancement of organoleptic characteristics is achieved, small scale producers in Croatia still produce spontaneously fermented game meat sausages as they still surpass in sensorial properties. Such artisan products are increasingly appreciated because of their authenticity although of great consideration due to their variable microbiological and organoleptic quality. Overall monitoring of wildlife reservoir is needed in assessment its potential as sources for zoonosis agents exposures of humans as well as sources of bacterial strains relevant for enhancement and standardization of game meat sausages production. There are large variations in prevalence of microbial populations of game meat even within a single country and the published data for Croatia is limited and poorly documented which does not allow any related analysis. Especially the data on risk -based monitoring of zoonosis and antibiotic resistance genes transmission via game meat food chain in Croatia is missing and there is not authentic collection of indigenous bacterial strains that could act as a pool of novel genes and metabolic pathways relevant for high quality food production. MiCROgame focuses on the in situ diversity analysis as well as detailed characterization of lactic acid bacteria (LAB) isolated from traditional Croatian game meat sausages. Application of this autochthonous microbiota into the sausages production can influence the end-product quality and can accelerate maturation such helping producers to be more competitive on national or EU market. Special focus will be set towards identification and characterization of potential spoilage and pathogenic microflora and antibiotic resistance traits in order to estimate safety of locally produced game meat food and to identify sources of contamination. ]]></summary_en></project><project>
<id>2479</id><title_hr><![CDATA[Raznolikost i interakcije kestena, patogene gljive koja izaziva rak kestena i virusa koji inficira gljivu: učinak na oporavak kestena]]></title_hr><title_en><![CDATA[]]></title_en><user_id>761</user_id><user_firstLast_name>Mirna  Ćurković Perica</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2014-06</proposal_call><code>DOK-2014-06-8059</code><acronim><![CDATA[Chestnut]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Biologija, </scie_field_hr><scie_field_en>Biology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>17770</team_members_id><team_members_names><![CDATA[ Doktorand: Lucija Nuskern ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[biological control, chestnut disease, epigenetics, hypovirulence, molecular ecology]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[European sweet chestnut is an important multipurpose tree species. For decades, chestnut blight, a disease caused by one of the world´s most aggressive invasive pathogens Cryphonectria parasitica has been causing high mortality in chestnut forest populations and orchards. However, the fungus can be controlled by the naturally-occurring virus Cryphonectria hypovirus 1 (CHV1) which causes a reduction in fungal virulence and sporulation (a phenomenon called hypovirulence), which in turn enables infected trees to recover. Hypovirulence is the most efficient way to successfully control chestnut blight in Europe, but unfortunately the spread of CHV-1 is limited by the fungal diversity and its sexual reproduction. This project aims at revealing individual and joint aspects of the dynamic three-lateral interaction between chestnut, its fungal pathogen and the pathogen-biocontrol agent-virus. The proposed study will: (1) reveal the diversity of natural chestnut populations in south-eastern Europe, (2) connect the sequences and 3-D structures of CHV1 subtype I proteins with the level of fungal hypovirulence, (3) reveal the role of epigenetic changes of fungal genome in respect to hypovirus infection and geographical spread of the fungus (4) assess the efficiency of naturally-occurring virus isolates to induce chestnut recovery in natural conditions. The results will also contribute to the combat efforts against chestnut blight in the field conditions, by enabling production of therapeutic paste for induction of recovery in a valuable chestnut cultivar.]]></summary_en></project><project>
<id>2480</id><title_hr><![CDATA[Karakterizacija niskotemperaturne molekulske dinamike sustava s neuređenom rešetkom metodom ESR]]></title_hr><title_en><![CDATA[]]></title_en><user_id>510</user_id><user_firstLast_name>Marina Ilakovac Kveder</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2014-06</proposal_call><code>DOK-2014-06-9812</code><acronim><![CDATA[DESiRe]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, </scie_field_hr><scie_field_en>Physics, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>17790</team_members_id><team_members_names><![CDATA[ Doktorand: Jurica Jurec ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[ESR, disorder, boson peak, spin relaxation, spin frustration]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Systems exhibiting geometrical frustration challenge contemporary condensed-matter physics due to the fact that they exhibit strange dynamical properties such as boson peak excitations, which strongly deviate from the standard Debye model. Therefore, the quest for a self-consistent theory applicable for description of systems with lattice disorder is a fundamental issue. Despite the efforts put into investigation of vibrational excitations in disordered systems at low temperatures, the consensus about their physical origin is still lacking. This project aims to address the subject by fully exploiting the advantage of embedded paramagnetic centres through focusing on their relaxation behaviour, which bears the information about the local frustration of the environment. The energy exchange within the spin system and between the spin system and the lattice will be detected by electron spin resonance spectroscopy (ESR) as a function of disorder in the vicinity of the paramagnetic centre. This we can control by preparing the host matrix in the glassy, supercooled or crystalline state. We propose to investigate the specific molecular dynamics due to the presence of disorder in the system while switching the very same compound doped with paramagnetic centres from disordered to more ordered state, such as from glassy to crystalline state. Additionally, the microscopic picture of local disordered sites will be examined in other systems doped with paramagnetic centres such as various polymer matrices or hydrogen-bonded crystals. The origin of local disorder will be correlated with the influence of different numbers of hydrogen bonds in the vicinity of paramagnetic site as well as with the degree of local spin frustration. We expect that this comparative study will enlighten the peculiarities of vibrational density of states of amorphous materials and contribute towards development of the unique model of low-temperature molecular dynamics of disordered systems in general.]]></summary_en></project><project>
<id>2481</id><title_hr><![CDATA[Rekombinacija, popravak DNA i očuvanje integriteta genoma: novi putevi]]></title_hr><title_en><![CDATA[]]></title_en><user_id>5202</user_id><user_firstLast_name>Davor Zahradka</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2014-06</proposal_call><code>DOK-2014-06-3252</code><acronim><![CDATA[RECNEWPATH]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Biologija, </scie_field_hr><scie_field_en>Biology, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>17821</team_members_id><team_members_names><![CDATA[ Doktorand: Ana Hlevnjak ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[hommologous recombination, DNA repair, genome stability, Escherichia coli, Deinococcus radiodurans, RecA protein, gross chromosomal rearrangements]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Homologous recombination is an essential biological process that is involved in DNA repair and in the maintenance of genome integrity. The RecA protein is a key component of recombinational systems in bacteria. Its homologs are also present in higher organisms including humans. RecA functions in the form of nucleoprotein filaments that are assembled on single-stranded DNA, and which catalyze pairing and strand exchange between two homologous DNA duplexes. In Escherichia coli, the RecBCD and RecFOR protein complexes mediate RecA filament assembly, and consequently, play an important role in recombination. We have recently discovered that some E. coli mutants recombine quite efficiently in the absence of both RecBCD and RecFOR complexes. This recombination is RecA-dependent suggesting the existence of an alternative RecA loading activity. The aim of the project is to genetically characterize this RecBCD- RecFOR-independent (RecBFI) recombination pathway, and gain insight into this novel mechanism of RecA filament assembly. Although RecA is crucial for efficient recombination in bacteria, the recA mutants of radiation-resistant bacterium Deinococcus radiodurans display a significant residual ability to repair double-strand DNA breaks. Recent results from our group have shown that this RecA-independent repair is quite inaccurate leading to gross chromosome rearrangements. Our project is to identify the key genes/proteins involved in this RecA-independent repair, and to characterize, at the sequence level, gross genome rearrangements in D. radiodurans. Given that recombination is a fundamental process largely conserved during evolution, our research on bacteria may reveal molecular mechanisms that are applicable to eukaryotic recombination systems. Thus, the results of our project could be instructive for research on cancer and other human hereditary diseases related to defects in DNA recombination functions. ]]></summary_en></project><project>
<id>2482</id><title_hr><![CDATA[Mulitidisciplinarni pristup otkriću lijekova s ciljanim djelovanjem na matične stanice tumora – uloga transporta kalija ]]></title_hr><title_en><![CDATA[]]></title_en><user_id>613</user_id><user_firstLast_name>Marijeta Kralj</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2014-06</proposal_call><code>DOK-2014-06-3177</code><acronim><![CDATA[MultiCaST]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>17804</team_members_id><team_members_names><![CDATA[ Doktorand: Iva Guberović ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[cancer stem cells, potassium transport, salinomycin, crown ethers, ion channels, ABC transporters, predictive QSAR modeling, drug discovery, therapy]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Targeting cancer stem cells (CSC), rather than cancer cells in general, is a novel and highly promising strategy for cancer treatment. The defining characteristics of CSC are self-renewal, propagation into heterogeneous lineages of cancer cells, and increased resistance to chemotherapy, thus, attacking the CSC should abolish a tumor&#39;s ability to recur or metastasize. Recently, a natural potassium ionophore salinomycin was identified as one of a few available CSC-selective substances, but the precise mechanism of its selectivity remains elusive. Based on hypothesis that the potassium transport is an important process of CSC biology, the objective of the proposed research is to understand fundamental processes of CSC-resistance to therapy and to discover novel compounds with ion homeostasis-modulating properties to selectively target CSC. Project methodology orchestrates research in three principle areas and their close interactions, covering synthesis and characterization of molecules (chemistry), assessment of their activity in biological models (biology, medicine) and computer-aided drug design (computational sciences). We’ll focus on salinomycin and a series of proprietary crown ether compounds, which will be optimized and developed. Their efficacy/selectivity and influence on drug transporters P-gp- and/or ABCG2-mediated efflux of chemoterapeutics will be assessed, as well as the toxicity and in vivo activity of the most promising compound. Deploying cutting-edge techniques in cell and molecular biology, bioimaging, molecular electrophysiology and transgenic cell lines (e.g. a unique CSC model - HMLEshEcad cells) we will strive to recognize novel biomarkers for identification and enrichment of CSC, related to abnormal potassium transport regulation that promote acquisition of CSC phenotype and/or influence their proliferation, death and migratory potential. The ultimate aim is to translate this knowledge into innovative mechanism-based therapeutic approaches. ]]></summary_en></project><project>
<id>2483</id><title_hr><![CDATA[Dijagnostika Interakcije lasera i hladne plazme]]></title_hr><title_en><![CDATA[]]></title_en><user_id>140</user_id><user_firstLast_name>Slobodan Milošević</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2014-06</proposal_call><code>DOK-2014-06-3950</code><acronim><![CDATA[LaCPID]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, </scie_field_hr><scie_field_en>Physics, </scie_field_en><institution_hr><![CDATA[Institut za fiziku]]></institution_hr><institution_en><![CDATA[Institute of Physics in Zagreb]]></institution_en><team_members_id>17797</team_members_id><team_members_names><![CDATA[ Doktorand: Dean Popović ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[low temperature plasmas, laser produced plasmas, cold plasmas, atmospherics plasmas, laser spectroscopy]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Cold and low-density plasmas are currently in focus of basic research worldwide due to many open questions regarding their complex nature and simultaneously due to their high potential for applications in various fields of research and technology. Plasmas can be produced by bombarding matter either with energetic electrons or with energetic photons. The first kind is related to use of various discharges and the second to use of powerful lasers. Our interest is in plasmas produced in vacuum, under low-pressure gas environment, at atmospheric air or on/within liquids. Discharges which we use range from electrodeless, single electrode to various designs of two electrode systems. Lasers we use are cw or pulsed nanosecond.  In our research special care will be devoted to tailoring the electron energy distribution functions as a key factor influencing plasma content and features. This is usually done by changing macroscopic plasma parameters - gas pressure, electrical fields and geometry of discharges. In this project we shall combine laser produced plasmas with discharge plasmas to achieve that goal. To understand the complex nature of plasma or processes of plasma interaction with other matter phases (gases, liquids and solids) basic approach is to perform plasma diagnostics by various types of optical and laser spectroscopies. To interpret findings we study basic atomic collision processes in plasmas and structure and spectra of various complexes formed within plasma (dimers, radicals etc). Modeling of various processes within cold plasmas and laser produced plasmas is performed in addition. In various applications in which plasma treatment of matter is used there is a need for in situ monitoring of processes both in plasma and at interfaces and therefore both spatial and temporal spectral resolution of applied detection techniques are important. We use classical emission and absorption laser spectroscopies and modern techniques such as a cavity ring-down spectroscopy.]]></summary_en></project><project>
<id>2484</id><title_hr><![CDATA[Klasifikacija i objašnjenja antisocijalnog poremećaja osobnosti i moralna i kaznena odgovornost u kontekstu Hrvatskog zakona o mentalnom zdravlju i skrbi]]></title_hr><title_en><![CDATA[]]></title_en><user_id>4121</user_id><user_firstLast_name>Luca Malatesti</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2014-06</proposal_call><code>DOK-2014-06-9522</code><acronim><![CDATA[CEASCRO]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Filozofija, </scie_field_hr><scie_field_en>Philosophy, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Filozofski fakultet u Rijeci]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Humanities and Social Sciences]]></institution_en><team_members_id>4172</team_members_id><team_members_names><![CDATA[ Doktorand: Marko Jurjako ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[antisocial personality disorders, psychiatric classification,  psychiatric explanation, moral responsibility,  Croatian mental health law and care]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[This interdisciplinary project investigates the problem of the social response in Croatia to a class of offenders classified as having antisocial personality disorders. The core methodology consists in  conducting philosophical investigations that are aimed at offering practical recommendations and that are constrained by knowledge of the practical setting of Croatian mental health law and care.  Two central philosophical issues appear to be relevant to the philosophical investigation and, thus, addressing them  is the aim of the project. First, a significant part of the contemporary debate on the social response to antisocial personality disorder centers on this notion. Some have argued that this notion involves normative preconceptions  against the liberties of certain individuals. Others have questioned the accuracy and scientific robustness of the diagnosis of antisocial personality disorders and its precision of related risk predictions.  Second, the justification for choosing the appropriate treatment for people with antisocial personality disorder must also be a moral one. In particular, a relevant type of moral justification has to be grounded in principles that correlate psychological descriptions and explanations of a person’s behavior with his or her degree of responsibility.  Similarly, compulsory treatment appears to be conditional upon a person’s diminished responsibility or capacity to act accordingly to a treatment decision, together with the existence of a risk to themselves or to others.The philosophical investigation of the project will be integrated with the contributions of  a leading forensic psychiatrist in Croatia, a sociological qualitative analysis of the practices and challenges that are encountered by institutional representatives in the forensic department of the Rab psychiatric hospital and an historical investigation of the institutional response to antisocial personality disorder in the region in the period 1918-1980.]]></summary_en></project><project>
<id>2486</id><title_hr><![CDATA[Nestali jezerski krajobrazi istočnog dijela Jadranskog mora]]></title_hr><title_en><![CDATA[]]></title_en><user_id>162</user_id><user_firstLast_name>Slobodan Miko</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2014-06</proposal_call><code>DOK-2014-06-7454</code><acronim><![CDATA[ LoLADRIA]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Geologija, </scie_field_hr><scie_field_en>Geology, </scie_field_en><institution_hr><![CDATA[Hrvatski geološki institut]]></institution_hr><institution_en><![CDATA[Croatian Geological Survey]]></institution_en><team_members_id>17774</team_members_id><team_members_names><![CDATA[ Doktorand: Dea Brunović ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[Paleolimnology, Paleoclimate, Last Glacial Maximum, Holocene, Pleistocene, Mesolithic, Sea Level Rise, Proxies, Human Migration, Adriatic Shelf, Karst]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[The LoLADRIA project represents a multidisciplinary, effort to recover, for the first time, long paleoenvironmental, and paleoclimate records from existing coastal karst lakes and submerged karstic lakes of the eastern Adriatic shelf in Croatia. The project will attempt to reconstruct the specific karst lake landscapes and their surroundings in view of environmental and climate change and human migration from the Last Glacial Maximum (LGM) through the Holocene. LoLADRIA will provide long, high resolution, paleohydrological reconstructions from a region extremely sensitive to changes in effective moisture and atmospheric dynamics. The multiproxy-based reconstructed curves will provide new data to identify and date the main climate events, and to characterize the climate variability at century and millennium scale since the LGM. Pollen and ostracods offer the possibility to develop transfer functions in order to reconstruct quantitative changes in regional climate and hydrological conditions of the lakes. LoLADRIA will offer an environmental context which enabled the human entrance to Europe along the eastern Adriatic shelf since this pathway is still widely unknown and the detailed framework of climatic and environmental conditions still requires extensive research. In combination with landscape reconstruction based on high resolution geophysical methods will allow the insight to the preserved changes in the landscapes at selected sites along the Eastern Adriatic and their habitability related to the Mesolithic cultures that were present there. Submarine  prehistoric  sites  in  the  Mediterranean  show  that  the  continental  shelf was  occupied  by  humans  to  a  depth  of  at  least  -40m, and the lost (submarine) lakes and surrounding submerged landscapes of the eastern Adriatic have a potential for site discovery.]]></summary_en></project><project>
<id>2487</id><title_hr><![CDATA[SINTEZA I CITOSTATSKA ISPITIVANJA  BIBLIOTEKE NOVIH DUŠIKOVIH HETEROCIKLA]]></title_hr><title_en><![CDATA[]]></title_en><user_id>76</user_id><user_firstLast_name>Silvana Raić-Malić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2014-06</proposal_call><code>DOK-2014-06-4842</code><acronim><![CDATA[SCIENcENTRY]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, </scie_field_hr><scie_field_en>Chemistry, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet kemijskog inženjerstva i tehnologije]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Chemical Engineering and Technology]]></institution_en><team_members_id>17839</team_members_id><team_members_names><![CDATA[ Doktorand: Andrea Bistrović ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[1,2,3-triazole-heterocycles hybrids, benzimidazoles, benzothiazoles, synthesis, cytostatic activity, in silico and docking analysis, DNA binding]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Cancer is one of the most serious health problems of a worldwide dimension. One in three of the population develops cancer at some time in their lives and one in four dies from this disease. The main problems in antitumor chemotherapy are drug resistance and side effects on normal tissues. In the recent years a tremendous growth was witnessed in synthesis and development of vast number and types of new heterocyclic antitumor agents, with an emphasis on creation of new drugs with better selectivity or activity. The latter are indeed major requirements in development of novel anticancer drugs. The proposed scientific project is highly interdisciplinary and objective-oriented with the principal aim to develop the novel lead compounds with pronounced and selective anticancer activity that would be used for further phases of drug development.To achieve the principal aim following specific tasks are foreseen. The goal of the first one is to synthesize small-compound library (Classes A–H) comprising new conjugates of pseudopurines, coumarines and quinolines with 1,2,3-triazole scaffold, N-acyclic 5-unsaturated pyrimidine derivatives, amino-, amido- and amidino substituted benzimidazole, benzothiazole and benzo[b]thieno-2-carboxamide derivatives. Molecule library will be synthesized using modern synthetic approaches such as click chemistry, palladium mediated cross-coupling, eco-friendly microwave assisted and photochemical reactions as well as classical organic synthetic methods. The aim of the second task is to predict plausible biological targets and pharmacological activities using cheminformatics/in silico analysis. The third task is to perform cytostatic evaluations based on which hit molecules with desired biological effect will be selected for structure optimization that will be subsequently carried out. Finally, the molecular mechanism studies are anticipated for the most effective compounds from synthesized N-heterocycles library.]]></summary_en></project><project>
<id>2488</id><title_hr><![CDATA[Sensitive measurement, detection, and identification of engineered nano particles in complex matrices – SMARTNANO (FP7 - NMP.2011.1.3-1 - Contract n°280779)]]></title_hr><title_en><![CDATA[]]></title_en><user_id>504</user_id><user_firstLast_name>Željko Jakšić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2014-06</proposal_call><code>DOK-2014-06-6175</code><acronim><![CDATA[]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Biologija, </scie_field_hr><scie_field_en>Biology, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>17752</team_members_id><team_members_names><![CDATA[ Doktorand: Maja Levak ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>2489</id><title_hr><![CDATA[Periodički npregnuti grfen; strukturna i elektroska svojstva]]></title_hr><title_en><![CDATA[]]></title_en><user_id>105</user_id><user_firstLast_name>Petar Pervan</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2014-06</proposal_call><code>DOK-2014-06-6205</code><acronim><![CDATA[PerStaGra]]></acronim><duration></duration><status>Prekinut</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, </scie_field_hr><scie_field_en>Physics, </scie_field_en><institution_hr><![CDATA[Institut za fiziku]]></institution_hr><institution_en><![CDATA[Institute of Physics in Zagreb]]></institution_en><team_members_id>17783</team_members_id><team_members_names><![CDATA[ Doktorand: Ivan Jedovnicki ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[graphene, strain, vicinal surface, fermi velocity, spin-orbit coupling, STM, ARPES]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[A strained graphene offers a valuable avenue for the manipulation in altering its electronic structure. Graphene can withstand rather large elastic deformation and it appears that within the elastic response there is a range of different modifications in graphene’s electronic structure. This is a basis of what is called “strain engineering”. Recent theoretical calculations suggest that uniaxial strain or shear deformations can induce opening of the electron band gap, anisotropic modification of the Fermi velocity, spin-orbit interaction  and consequently alter the transport properties. However, there is still no consensus on the mechanical conditions required to obtain a particular electronic modification. In this project we propose a systematic study of structural and electronic properties of periodically rippled graphene. We have already demonstrated that graphene conforms to the stepped (vicinal) iridium surface – Ir(332) creating periodic structure at nanometer scale. It is aim of this project to experimentally explore the dependence of the electronic structure of graphene with respect to periodicity of the graphene corrugation, orientation of the graphene with respect to the shear deformation (zig-zag with respect to armchair direction). By intercalation of different elements we will alter the graphene substrate interaction with the aim to control the structure of the underlying surface and consequently valence band structure of graphene. We shall investigate structural properties of graphene on Ir(332) by Scanning Tunneling Microscope (STM) and Atomic Force Microscope (AFM). The focus in the investigation of electronic properties will be on the ARPES study of anisotropic distortion of the Dirac cone, relation with the direction of the graphene modulation, spin-orbit interaction and on the possibility to induce electron band gap. ]]></summary_en></project><project>
<id>2491</id><title_hr><![CDATA[Metode slabih convergencija i primjene]]></title_hr><title_en><![CDATA[]]></title_en><user_id>58</user_id><user_firstLast_name>Nenad Antonić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2014-06</proposal_call><code>DOK-2014-06-1949</code><acronim><![CDATA[WeConMApp]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Matematika, </scie_field_hr><scie_field_en>Mathematics, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>86</team_members_id><team_members_names><![CDATA[ Doktorand: Marin Mišur ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[weak convergences, partial differential equation, homogenisation, optimal design, H-measures, semiclassical measures, transport problems]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Weak convergences are the foundation of most successful methods in the investigation of partial differential equations today. The approach known as Tartar&#39;s programme proved particularly convenient for partial differential equations modelling physical laws; the basic assumption being that weak convergences of sequences of solutions model the transition from microscale to macroscale. Of importance are also mathematical objects being, in a generalised sense, accumulation points of weakly convergent sequences, such as defect measures or H-measures. The research will be directed towards improving the existing weak convergence methods, designing new mathematical objects for that purpose, as well as developing new methods, with particular attention paid to their applications to practical problems.Problems known as homogenisation are tied to properties of mixtures of materials, with important applications in optimal design. Problems related to evolutionary equations and their admissibility conditions mainly concern transport problems in free and porous media, where it is sometimes natural to include continuous time random walk variables in the model. Such problems sometimes also lead to fractional derivative equations. Some problems are related to hyperbolic conservation laws and the propagation and interaction of singularities. High-frequency waves corresponding to solutions of hyperbolic systems are governed by ODEs, allowing for final interpretation as particles. Particularly interesting are situations where the equation changes its type (like transonic fluid flow), motivating our interest in Friedrichs systems. Further results for semilinear systems could open a new approach to the Maxwell-Dirac system, with potential applications in quantum field theory. Practical computation of coefficients in specific applications is also important; as the unknown functions have the domain in multidimensional space, quite often more efficient numerical methods have to be developed.]]></summary_en></project><project>
<id>2492</id><title_hr><![CDATA[LIFE13 ENV/HR/000580 „Niskopesticidna integrirana zaštita u održivoj i sigurnoj proizvodnji voća&#39;&#39;]]></title_hr><title_en><![CDATA[]]></title_en><user_id>253</user_id><user_firstLast_name>Tomislav Jemrić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2014-06</proposal_call><code>DOK-2014-06-5032</code><acronim><![CDATA[]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Biotehnologija, </scie_field_hr><scie_field_en>Biotechnology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Agronomski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Agriculture]]></institution_en><team_members_id>17827</team_members_id><team_members_names><![CDATA[ Doktorand: Marko Vuković ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>2493</id><title_hr><![CDATA[Fleksibilna energetska čvorišta u nisko ugljičnim naprednim elektroenergetskim mrežama]]></title_hr><title_en><![CDATA[]]></title_en><user_id>6497</user_id><user_firstLast_name>Igor Kuzle</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2014-06</proposal_call><code>DOK-2014-06-5507</code><acronim><![CDATA[FENISG]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Elektrotehnika, </scie_field_hr><scie_field_en>Electrical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id>19028</team_members_id><team_members_names><![CDATA[ Doktorand: Kristina Jurković ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[energy/power nodes, smart grids, reneawable energy sources, distributed generation, energy storage, plug in electrical vehicles]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[The share of renewable energy sources (RES) in electric power systems (EPS) has increased during the recent years and this trend is expected to continue. The stochastic nature of electricity production from RES imposes new challenges for the EPS operation and control. A large share of undispatchable RES can lead to significant disturbances of EPS components. These disturbances need to be balanced out and the security of the system has to be preserved. If the resources for providing balancing energy and flexibility are limited, secure operation of the EPS will become highly expensive. Conventional generation units provide the necessary flexibility to maintain a continuous balance between supply and demand. The question is: are these conventional resources the most feasible way of providing system flexibility in the future low carbon systems? During the recent years, plug-in hybrid electric vehicles (PHEV) have become an attractive way of transportation. While passive approach to their integration might cause problems to the system, active utilization of their flexibility might enable higher penetration of RES. A similar reasoning can be applied to the distributed generation, especially technologies with the potential of multi energy vector interaction (efficient electric heating, combined heat and power, battery storage etc.).Current grids need to be capable of dealing with mentioned requirements. The concept of Smart Grid (SG) is based on using of novel information and communication technology (ICT) and includes application of a spectrum of innovative and flexible technologies.The purpose of this project is to establish a methodological and comprehensive framework providing the costs and benefits evaluation of SG projects and technologies. Given the sizeable investments needed, there is a need for a fair, consistent and methodological approach for estimation of the best investment option, taking into account economic and environmental aspects of a specific project.]]></summary_en></project><project>
<id>2494</id><title_hr><![CDATA[Zaštita privatnosti deidentifikacijom u nadzornim sustavima ]]></title_hr><title_en><![CDATA[]]></title_en><user_id>4290</user_id><user_firstLast_name>Slobodan Ribarić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2014-06</proposal_call><code>DOK-2014-06-2427</code><acronim><![CDATA[DePPSS]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Računarstvo, </scie_field_hr><scie_field_en>Computer sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id>17749</team_members_id><team_members_names><![CDATA[ Doktorand: Martin Soldić ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[privacy protection, biometric identification, de-identification, surveillance systems, video ]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Owing to advances of video surveillance systems it is possible, besides detection of people&#39;s behavioural anomalies, by using of reliable recognition software to perform identification and simultaneously trace people in the real time. Whilst it is recognized that there are justified reasons for acquisition and sharing videos in manners such as security, bio-terrorism surveillance applications, low enforcement and forensics, there is also a strong need for protecting the privacy of the guiltless individuals who are inevitably captured in the recordings. Video surveillance is privacy intrusive because it allows the observation of certain information that is considered privacy intrusive. Face has central role in the process of human recognition and identification in videos, thus the special attention has to be devoted to the face de-identification methods for privacy protection. De-identification addresses, in context of our project, the automated methods of concealing or/and removing face identifiers of individuals captured in videos. The importance of privacy protection is mirrored in documents such as UN Universal Declaration of Human Rights, and EU’s Data Protection Directive (95/46/EC) as well as commissioned review of the Data Protection Directive (95/46/EC) by the EU Information Commissioner’s Office from July 2008. The general public has become increasingly aware of the potential danger for their personal data to be abused.Beside scientific objectives and goals (robust face localization, novel methods for face de-identification in videos, preserving data utility and naturalness in de-identification videos, privacy protection), the main objectives of the proposed project are human resources (early stage researchers and PhD students) development by transfer of knowledge in the fields of advanced technologies to carry out problem-oriented research, and increasing a competitiveness level of the research team for Horizon 2020 project applications. ]]></summary_en></project><project>
<id>2495</id><title_hr><![CDATA[Towards an alliance of European research fleets (EUROFLEETs-II) ]]></title_hr><title_en><![CDATA[]]></title_en><user_id>195</user_id><user_firstLast_name>Ivica Vilibić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2014-06</proposal_call><code>DOK-2014-06-5127</code><acronim><![CDATA[]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Geofizika, </scie_field_hr><scie_field_en>Geophysics, </scie_field_en><institution_hr><![CDATA[Institut za oceanografiju i ribarstvo]]></institution_hr><institution_en><![CDATA[Institute of Oceanography and Fisheries]]></institution_en><team_members_id>17732</team_members_id><team_members_names><![CDATA[ Doktorand: Natalija Dunić ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>2499</id><title_hr><![CDATA[Unaprijeđeno istraživanje općekorisnih funkcija šuma]]></title_hr><title_en><![CDATA[]]></title_en><user_id>3207</user_id><user_firstLast_name>Damir Medak</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2014-06</proposal_call><code>DOK-2014-06-4224</code><acronim><![CDATA[AFORENSA]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Geodezija, </scie_field_hr><scie_field_en>Geodesy, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Geodetski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Geodesy]]></institution_en><team_members_id>17863</team_members_id><team_members_names><![CDATA[ Doktorand: Luka Rumora ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[Forest environmental services, Remote sensing, Ecohydrology, Biodiversity, GIS, Climate change ]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[The main objective of AFORENSA is to generate relevant knowledge how the forest ecosystems in Croatia responds to observed extreme climatic variations, and what are possible future expectations in respect to the progression of climate change and disturbances of natural hydrologic cycle with intensification of drought frequency and severity. This objective is aimed to be resolved by implementing of the novel forest ecosystem assessment approach, applicable for the country scale, which incorporates: a) traditional in situ ecosystem survey (soil and vegetation), b) analysis of the functional state of the ecosystems by remote sensing, c) downscaling of the regional climatic models and d) coupling of scenario outputs with ecohydrological models on a site specific environmental settings. The core system on which AFORENSA activities will be build up, presents “Dynamical Geoinformation system of forest ecosystems in Croatia” (DYN-CROFOR), a technological project financed by the Ministry of Science and Education from 2003 to 2007. Aforensa is aiming at the inventory, and integration of terrestrial forest ecosystem research on the Web-Gis (DYN-CROFOR) platform incorporating automatized procedures for retrieving remote sensing data (such as MODIS and MERIS vegetation indices)  and with the  addition of incorporating Data mining procedures and the full power of R, a language and environment for statistical computing and graphics. Project workflow consists of four, interrelated, work packages: a) INVENTORY, b) AUTOMATIZATION, c) MINING, d) UPGRADING. AFORENSA will contribute with speeding-up of future exploratory forest ecosystem research, and with its capability of near real time data processing will present a basis for the development of “Forest watch”; an observatory for early determination of potentially harmful effects of Climate Change on forest ecosystem services such as biodiversity and water.]]></summary_en></project><project>
<id>2501</id><title_hr><![CDATA[Računalna rješenja u bioznanostima: Značaj savitljivosti molekula]]></title_hr><title_en><![CDATA[]]></title_en><user_id>326</user_id><user_firstLast_name>David Smith</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2014-06</proposal_call><code>DOK-2014-06-6776</code><acronim><![CDATA[CompSoLS-MolFlex]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, </scie_field_hr><scie_field_en>Chemistry, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>18936</team_members_id><team_members_names><![CDATA[ Doktorand: Marko Hanževački ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[Molecular Flexibility, Computational Chemistry, Peptides, Proteins, Enzyme Catalysis]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Molecular flexibility controls a number of key processes ranging from protein folding to the design of advanced materials. However, the detailed understanding of its impact on a given process is poorly understood. Direct investigation of this phenomenon by experimental means, is a challenging endeavour, as the microscopic details are frequently hidden from macroscopic observations. Computational simulations, on the other hand, provide detailed information regarding molecular dynamics and flexibility. The theoretical approach is thus crucial in both understanding the experimental results and in expanding the underlying conceptual framework.The present project proposes to utilize state-of-the-art computational techniques to address the importance of molecular flexibility across a range of carefully selected examples from the life sciences. The examples, which can be classified under the headings: (i) peptides and spectroscopy, (ii) protein flexibility, and (iii) enzyme related transformations, have been chosen to span multiple time and length scales and thus to highlight the diverse and wide-reaching nature of molecular flexibility. The selected examples exhibit a significant degree complementarity and synergy with one another and are all associated with their own applicative importance in different areas of (bio)chemistry.In addition to the scientific research proposed, the project aims to consolidate a highly successful and competitive platform in computational life sciences that has been established at the RBI. This platform was already recognized through the granting of an EU-FP6 project (2007-2010). The current project team is thus well equipped for the proposed work and exhibits a good balance between senior researchers, with excellent track records, and junior scientists with outstanding potential. The support of the project team by HrZZ is crucial for maintaining their competitiveness in the international scientific environment of computational life sciences.]]></summary_en></project><project>
<id>2502</id><title_hr><![CDATA[Jezična obrada u odraslih govornika]]></title_hr><title_en><![CDATA[]]></title_en><user_id>400</user_id><user_firstLast_name>Jelena Kuvač Kraljević</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2014-06</proposal_call><code>DOK-2014-06-3854</code><acronim><![CDATA[ALP]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Logopedija, </scie_field_hr><scie_field_en>Logopedics, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Edukacijsko-rehabilitacijski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Education and Rehabilitation Sciences]]></institution_en><team_members_id>17791</team_members_id><team_members_names><![CDATA[ Doktorand: Marina Olujić ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[language processing, adult and elderly population, language disorders, executive functions, linguistic aphasiology]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Adult Language Processing project is intended to address psycholinguistic and neurolinguistic aspects of the aging population in Croatia. As an installation research project it will help set up an interdisciplinary and multidisciplinary research group that would tackle all aspects of the language processing in adults and in the aging population. Clinical groups (patients with aphasias, dementias and dyslexia) will be included into the project; language breakdown in these clinical groups helps in the study of language processing in healthy adults and vice versa. It is generally assumed that the subtle changes in language processing in the aging population arise from the cognitive decay related to executive functions, not language per se. The decrease in the processing speed influences language processes that require fast execution or simultaneity. This results in a typical pattern of changes, different from the ones in clinical populations. Therefore, executive functions in these groups will be studied in order to build a comprehensive model of adult language processing. Theories of language processing (namely, Role and Reference Grammar - RRG) will be considered to define specific traces of language processing that assume fast execution or simultaneity and therefore should be the most vulnerable in aging population. These traces will be defined and described which will put Croatian into a cross-linguistic perspective in contemporary studies of linguistic aphasiology and provide coherent picture of age related changes in adult language system.  ]]></summary_en></project><project>
<id>2503</id><title_hr><![CDATA[Optimiranje i modeliranje termalnih procesa materijala]]></title_hr><title_en><![CDATA[]]></title_en><user_id>1419</user_id><user_firstLast_name>Dario Iljkić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2014-06</proposal_call><code>DOK-2014-06-4469</code><acronim><![CDATA[OMOTPOM]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Strojarstvo, </scie_field_hr><scie_field_en>Mechnical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Tehnički fakultet]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Engineering]]></institution_en><team_members_id>25439</team_members_id><team_members_names><![CDATA[ Doktorand: Andrej Borić ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[materials processing, modelling, electroless plating, electroactive composites, optimisation, modelling]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Phenomena of physical processes during the thermal processes will be investigated. Methods for modeling and computer simulations of thermal processes of materials will be developed. Thermal processes, such as, heat treating processes of steel, hot pressing of powder metals and casting of alloys of light metals will be investigate. The study of heat treatment of steel will be focused on quench hardening and tempering, and control cooling during the hot working and steel casting. Thermal stability of electro-active composites will be analyzed. Optimization of electro-less Ni-P coating of stainless steel and thermo-diffusive heat treatment of layers will be studied. Methods of optimization of application of tools and dies in thermal processing of materials will be studied. Models and computer programs for simulation of behavior steel dies during casting of light metal alloys and hot pressing of metal powders will be developed.During the thermal processes primary will be studied physical processes and material properties such as: heat transfer, microstructure transformations, mechanical properties and distortions and residual stresses. Numerical model of physical phenomena will be preferable based on finite volume method (FVM). To solve these tasks, joined thermo-mechanic-metallurgical approach will be required. The computer program for 3-D simulation of heat transfer, microstructure transformations, mechanical properties, distortions and residual stresses during the thermal processes will be developed.]]></summary_en></project><project>
<id>2504</id><title_hr><![CDATA[Modeliranje toka podzemnih voda u krškim vodonosnicima]]></title_hr><title_en><![CDATA[]]></title_en><user_id>6687</user_id><user_firstLast_name>Hrvoje Gotovac</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2014-06</proposal_call><code>DOK-2014-06-4310</code><acronim><![CDATA[Karst modelling]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Građevinarstvo, </scie_field_hr><scie_field_en>Civil engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Splitu Fakultet građevinarstva, arhitekture i geodezije]]></institution_hr><institution_en><![CDATA[University of Split, Faculty of Civil Engineering, Architecture and Geodesy]]></institution_en><team_members_id>17887</team_members_id><team_members_names><![CDATA[ Doktorand: Luka Malenica ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[karst aquifers, groundwater flow modeling, multiresolution and multiscale approach, karst heterogeneity, distributive karst models]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Karst aquifers are very important groundwater resources around the world as well as in coastal part of Croatia. They consist of extremely complex structure defining by triple phases: slow porous medium, mostly laminar fractures and usually fast turbulent conduits/karst channels. Usually, karst aquifers have been analyzed by lumped hydrological models which ignore high heterogeneity of karst and consider only input (precipitation) and output (spring discharge) due to lack of extensive other input data and knowledge regarding the karst system. Last two decades full hydraulic (distributive) models have been developed exclusively by conventional finite elements considering karst heterogeneity structure that improves our understanding of complex processes in karst. Therefore, in this project we will develop novel “unique” flow model based on multi-resolution approach originally designed by Gotovac et al. (2007-2013) for 1-D and 2-D groundwater flow and transport simulations. Proposed approach is based on Fup basis functions with compact support and meshless collocation procedure enabling multi-scale representation of heterogeneity and other flow variables, closely related to the karst flow physical interpretation. Moreover, extending existing procedure to 3-D and constructing separate multi-scale solution for all three karst phases, proposed approach will enable the following impacts in comparison to conventional methods: desired spatial and temporal accuracy and high computational efficiency, modular model structure, incorporation of different heterogeneity scales related to existing measurements, enabling of transport and tracer test analysis and better understanding of karst aquifers due to solving of different engineering problems such as water usage and protection or contaminant pollution. Flow model will be verified by laboratory experiments and numerical synthetic benchmarks as well as real examples such as Jadro catchment and Ombla underground accumulation.]]></summary_en></project><project>
<id>2505</id><title_hr><![CDATA[Urbanizam naslijeđa - Urbanistički i prostorni modeli za oživljavanje i unaprjeđenje kulturnoga naslijeđa]]></title_hr><title_en><![CDATA[]]></title_en><user_id>1458</user_id><user_firstLast_name>Mladen Obad Šćitaroci</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2014-06</proposal_call><code>DOK-2014-06-2984</code><acronim><![CDATA[HERU]]></acronim><duration></duration><status>Prekinut</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Arhitektura i urbanizam, </scie_field_hr><scie_field_en>Architecture and Urban Environment, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Arhitektonski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Architecture]]></institution_en><team_members_id>3237</team_members_id><team_members_names><![CDATA[ Doktorand: Nikola Matuhina ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[Cultural Heritage, Urban Planning, Spatial Planning, Heritage Enhancement, Heritage Revival]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Croatia’s urban heritage is at least 25 centuries old. Examples of cultural/architectural and landscape heritage in Croatia are numerous, valuable and diverse. Part of this heritage is recognised worldwide and is protected by UNESCO. Croatia’s most valuable heritage is protected at a national level, although a part of it has, as yet, not been recognised. For various reasons the numerous examples of Croatian heritage are in a poor condition and decaying because they don’t have a permanent use and are not included in the life of cities and towns, despite being formally protected.In former research project, Urban and Landscape Heritage of Croatia as Part of European Culture, cultural heritage was researched in an attempt to present its values and traits as part of Croatia’s national identity and culture. The new project proposal partly supplements previous project thematically and uses results of this research, but the focus of research is on the creative, sustainable and responsible usage of urban, architectural and landscape heritage, which is a non-renewable resource. Contemporary attitudes of conservationists on the holistic protection based on international conservation documents connect protection with urban and regional planning through the concept of sustainable development. The aim of proposed research is to affirm heritage as an active space and spatial resource, to include it in future life and to allow it to be the initiator and active participant in sustainable spatial, social and cultural, economic and touristic development.The research will be based on the selected case studies for each type of cultural heritage. The aim is to define spatial criteria, methods and models for revitalisation and for the implementation of new projects within cultural heritage which may contribute to their enhancement. The project results (criteria, methods, models) will be applied in spatial and urban planning and conservation practices, and will be of far-reaching impact.]]></summary_en></project><project>
<id>2506</id><title_hr><![CDATA[Nekovalentne interakcije u dizajnu novih fotoosjetljivih molekula]]></title_hr><title_en><![CDATA[]]></title_en><user_id>243</user_id><user_firstLast_name>Davor Margetić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2014-06</proposal_call><code>DOK-2014-06-1851</code><acronim><![CDATA[NoncoPhoto]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, </scie_field_hr><scie_field_en>Chemistry, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>17759</team_members_id><team_members_names><![CDATA[ Doktorand: Mateja Đud ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[physical-organic chemistry, green chemistry, synthesis, computational chemistry, organic materials]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Project addresses two key research objectives in the European Union: energy and environment conservation. The scientific approach is based on a combination of theoretical and experimental knowledge and experience of collaborators, and includes quantum-chemical calculations and molecular modelling in the molecular design, chemical synthesis and physico-chemical characterisation of molecules.The aim of project is to study fundamental physico-chemical properties of supramolecular systems built by non-covalent interactions (NC) - hydrogen bonding and metal-ligand coordination. The objectives are: a) Synthesis and structural characterization of functionalized bis-chromophoric molecular systems possessing guanidine, (thio)urea and carboxylate functionalities by employment of novel environmentally friendly synthetic methods; b) Detailed insight into the fundamental mechanisms how NC bonds mediate excited energy-transfer processes from one chromophore to another within assemblies; c) Analysis of influence of guanidine and (thio)urea functionalities and their anion complexation on the spectroscopic properties; d) Study of novel assemblies based on NC interactions and influence of different media; e) Development of model heterogeneous photo-responsive catalysis materials; f) Construction of complex multichromophoric supramolecular assemblies.Results of fundamental studies carried out within this project will enrich the understanding of physico-chemical factors in electron transfer processes in supramolecular systems constructed of chromophoric pairs employing the non-covalent bonding. Expected results will enable design of novel photoactive systems which could be applied in the technological development including sensors, fluorescent probes in biomedicine, organic photovoltaics, molecular electronics and heterogeneous catalysis.]]></summary_en></project><project>
<id>2508</id><title_hr><![CDATA[Višeskalno numeričko modeliranje deformiranja materijala od makro do nanorazine]]></title_hr><title_en><![CDATA[]]></title_en><user_id>927</user_id><user_firstLast_name>Jurica Sorić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2014-06</proposal_call><code>DOK-2014-06-2938</code><acronim><![CDATA[MNumMacroNano]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Strojarstvo, </scie_field_hr><scie_field_en>Mechnical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet strojarstva i brodogradnje]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Mechanical Engineering and Naval Architecture]]></institution_en><team_members_id>17578</team_members_id><team_members_names><![CDATA[ Doktorand: Filip Putar ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[Engineering materials, bilogical tissues, multiscale modeling, finite element  method, meshless method, damage modeling, molecular dynamics]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Many engineering materials as well as biological tissues have a heterogeneous structure particularly when they are observed at microlevel. In order to assess structural integrity as well as to predict structural lifetime, an analysis at microlevel is required. In recent years, a special attention has been directed to the investigation of relations between macroscopic properties of materials and their microstructure as well as to perform a link to atomistic scale. Since classical continuum mechanics cannot consider structural effects in the material at the micro- and nanolevel, multiscale techniques are developed that model material deformation responses at multiple levels using appropriate numerical procedures. Deformation responses of arteries will be considered by using multiscale computational strategy too. A special attention will be directed toward the mathematical modeling of arterial growth and remodeling, which could help physicians to track certain cardiovascular diseases and predict their development. For modeling of engineering materials, a new micro-macro numerical procedure based on the second-order computational homogenization approach employing nonlocal continuum theory will be proposed. Both finite element and meshless spatial discretization will be applied. The damage evaluation at the microlevel which may lead to macroscopic fracture will be modeled. Here the damage evaluation law based on the computational averaging procedure will be used and the modeling at atomistic scale will be performed in the very narrow domain of localization. In the atomistic modeling using molecular dynamics, a special attention will be directed to the coupling of atomistic domain with the discretized continuum domain. An approach inspired by the quasicontinuum and bridging domain will be proposed. All results of the research will be tested by the modeling deformation responses of realistic materials.]]></summary_en></project><project>
<id>2509</id><title_hr><![CDATA[Optimization of Automatic Transmission Shift Control   (Optimiranje upravljanja promjenom stupnjeva prijenosa automatskog mjenjača)]]></title_hr><title_en><![CDATA[]]></title_en><user_id>11149</user_id><user_firstLast_name>Joško Deur</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2014-06</proposal_call><code>DOK-2014-06-2348</code><acronim><![CDATA[]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Strojarstvo, </scie_field_hr><scie_field_en>Mechnical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet strojarstva i brodogradnje]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Mechanical Engineering and Naval Architecture]]></institution_en><team_members_id>17751</team_members_id><team_members_names><![CDATA[ Doktorand: Vanja Ranogajec ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>2510</id><title_hr><![CDATA[FP7-ICT &#39;&#39;CADDY – Cognitive Autonomous Diving Buddy&#39;&#39;]]></title_hr><title_en><![CDATA[]]></title_en><user_id>5962</user_id><user_firstLast_name>Nikola Mišković</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2014-06</proposal_call><code>DOK-2014-06-4651</code><acronim><![CDATA[]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Elektrotehnika, </scie_field_hr><scie_field_en>Electrical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id>17737</team_members_id><team_members_names><![CDATA[ Doktorand: Filip Mandić ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>2511</id><title_hr><![CDATA[Otvaranje obrazovanja kroz učenje unutar i izvan škola i kolaboraciju na mobilnim tablet računalima]]></title_hr><title_en><![CDATA[]]></title_en><user_id>151</user_id><user_firstLast_name>Ivica Botički</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2014-06</proposal_call><code>DOK-2014-06-9536</code><acronim><![CDATA[SCOLLAm]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Računarstvo, </scie_field_hr><scie_field_en>Computer sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id>3612</team_members_id><team_members_names><![CDATA[ Doktorand: Tomislav Jagušt ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[seamless learning, mobile learning, technology enhanced learning, collaborative learning, informal learning, educational technology]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[This project explores the potential of using mobile technology for seamless and mobile learning in Croatia and proposes a technologically innovative mobile learning platform named SCOLLAm. Being one of the first scientific mobile learning projects in Croatian schools, it explores both technology and pedagogies through two studies leveraging tablet computers in Croatian classrooms. In the first study, SCOLLAm will be deployed in a primary school to support new seamless and collaborative lessons in and across the existing subjects. In the second study, augmented mobile learning technology and the accompanying digital lessons will be used as a tool to support seamless and collaborative learning in a vocational school. These studies seek to stimulate and explore the effectiveness of mobile learning in Croatian schools in a strictly scientific manner, by engaging in digital mobile lesson co-design with the school teachers. The project will leverage experience from mobile learning research groups from Singapore, Sweden and USA in order to develop a new set of tools and lessons suitable for Croatian educational system. In order to move away from the tools typically targeting one platform and providing only limited adaptation mechanisms with virtually no learning analytics, one of the project objectives is the design, development and deployment of a scalable, adaptive and analytics driven platform SCOLLAm. Through the designed studies, produced open localizable educational resources and the SCOLLAm platform, we expect to see that the participants benefit from the introduction and use of mobile technology and applications through increased learning, collaboration skills and self-directedness, and acquire 21st century skills needed in their further education and life.]]></summary_en></project><project>
<id>2512</id><title_hr><![CDATA[Evocirani potencijali moždanog debla i testiranje autonomnog živčanog sustava kao metode procijene progresije bolesti u bolesnika s klinički izoliranim sindromom]]></title_hr><title_en><![CDATA[]]></title_en><user_id>1081</user_id><user_firstLast_name>Mario Habek</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2014-06</proposal_call><code>DOK-2014-06-9971</code><acronim><![CDATA[BACIS]]></acronim><duration></duration><status>Prekinut</status><financ_value></financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Kliničke medicinske znanosti, </scie_field_hr><scie_field_en>Clinical sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb School of Medicine]]></institution_en><team_members_id>17860</team_members_id><team_members_names><![CDATA[ Doktorand: Luka Crnošija ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[clinically isolated syndrome, multiple sclerosis, evoked potentials, autonomic nervous system testing, brainstem]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[About 85% of patients have onset of MS with a relapse, which is known as a clinically isolated syndrome (CIS). Several studies have shown that infratentorial lesions are related to conversion rate and long-term prognosis for patients with CIS and thus may help to identify patients at high risk for earlier occurrence of clinically relevant disability. Bearing in mind the poor correlation between clinical symptoms and MRI findings there is a need for ancillary tools in the evaluation of brainstem pathology in MS. The aim of the current study is to evaluate the role of the brainstem evoked potentials score (bilateral AEP, bilateral ocular and cervical VEMP and bilateral tongue SSEP), the modified evoked potentials score (combination of brainstem evoked potentials score and VEP and SSEP of the median and tibial nerve) and standardized autonomic nervous system testing (Composite Autonomic Severity Score (CASS)) in the prediction of conversion from CIS to MS and accumulation of future disability. After 24 months of follow-up, this study could reveal the prognostic value of the brainstem EP score, modified EP score and CASS in patients with CIS on a number of parameters including: time until second relapse, accumulation of disability, accumulation of MRI lesions in the first 6 months, time to conversion from CIS to MS according to the 2010 revision of the McDonald criteria, number of relapses in the first 2 years of follow up. It can be presumed that the brainstem EP score and CASS score as direct and indirect measures of brainstem dysfunction, respectively will prove as reliable markers of future disability of CIS and MS patients. As a consequence, this would allow us to start more appropriate treatment in a subset of patients with higher probability of worse outcome.]]></summary_en></project><project>
<id>2513</id><title_hr><![CDATA[Diracovi operatori i teorija reprezentacija]]></title_hr><title_en><![CDATA[]]></title_en><user_id>5573</user_id><user_firstLast_name>Pavle Pandzic</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2014-06</proposal_call><code>DOK-2014-06-9187</code><acronim><![CDATA[representations]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Matematika, </scie_field_hr><scie_field_en>Mathematics, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>17808</team_members_id><team_members_names><![CDATA[ Doktorand: Karmen Grizelj ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[Harish-Chandra modules, Dirac operators, cohomology, Dirac induction, branching problems]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Dirac operators were introduced into representation theory by Parthasarathy in the 1970s. In the 1990s, Vogan conjectured a strengthening of Parthasarathy&#39;s Dirac inequality, which relates the cohomology of the Dirac operator to the infinitesimal character of the representation. This conjecture was proved in a joint paper with Huang . In further research, in part joint with various collaborators (Barbasch, Huang, Kang, Mehdi, Protsak, Renard, Somberg, Zhu) , we related Dirac cohomology to other kinds of cohomology, calculated it explicitly for many interesting representations, and studied algebraic Dirac induction, a construction of representations with given Dirac cohomology. The proposed project will continue this research in several directions: 1) the study of representations obtained by Dirac induction, in particular the discrete series representations (doctoral research of Ana Prlić). 2) applying Dirac cohomology to problems of restricting representations. Some instances of this have been studied with Huang-Zhu and with Somberg. 3) trying to strengthen the Dirac inequality, which should have implications for the study of unitary representations. Some preliminary work on  the convex hull conjecture of Salamanca-Vogan has been done with Renard. 4) calculating the Dirac cohomology of  unipotent representations. Some cases of this have been obtained jointly with Barbasch. This could lead to better understanding of characters of unipotent representations, which is related to the Assem conjecture. It would also be interesting to calculate the Dirac cohomology of unitary highest weight modules. Other topics we plan to cover include studying translation principle for Dirac index (joint with Mehdi and Vogan); studying n-cohomology and BGG resolutions using Penrose transforms (joint with Soucek);  studying some abstract homotopy and homology theory, with applications to tensor categories of representations (doctoral research of Matija Bašić).]]></summary_en></project><project>
<id>2514</id><title_hr><![CDATA[Matematičko modeliranje, analiza i računanje s primjenama na kompleksne mehaničke sustave]]></title_hr><title_en><![CDATA[]]></title_en><user_id>2945</user_id><user_firstLast_name>Zlatko Drmač</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2014-06</proposal_call><code>DOK-2014-06-5570</code><acronim><![CDATA[MMACACMS]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Matematika, </scie_field_hr><scie_field_en>Mathematics, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>17823</team_members_id><team_members_names><![CDATA[ Doktorand: Ivana Šain ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[scientific computing, complex mechanical systems, eigenvalue problems, model reduction, distributed control, high perfomance scientif computing]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[This proposal is focused on functional and numerical analysis of mathematical models of selected complex mechanical systems from mathematical physics and engineering, with particular emphasis on the development of numerical methods and robust algorithms for computing. Such operator theoretic models are particularly amenable to be treated algebraically in the context of efficient and robust computational procedures of modern numerical linear algebra. The themes include adaptive (interior penalty) discontinuous Galerkin method in the penalty based formulation of the model for the complex mechanical system (e.g. stent), and vibration analysis for powertrains (car industry).  In a related topic of vibration control, we study distributed control using dynamic multipliers from the dissipativity theory.  In the frequency domain, we consider the problems of system identification and model order reduction posed as problems of rational approximation in the Hardy space H2. For all considered problems, we devise numerical algorithms and identify core numerical linear algebra computational tasks for which we plan to develop robust algorithms. These include Arnoldi-type eigensolver for both linear and quadratic large scale eigenvalue problems, and high accuracy algorithms for structured matrices of paired Cauchy structure. All developed algorithms will be delivered also as high performance mathematical software.]]></summary_en></project><project>
<id>2516</id><title_hr><![CDATA[Promjene u kristaliničnim materijalima izazvane ionskim snopovima MeV-skih energija]]></title_hr><title_en><![CDATA[]]></title_en><user_id>4589</user_id><user_firstLast_name>Stjepko Fazinić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2014-06</proposal_call><code>DOK-2014-06-4153</code><acronim><![CDATA[MIOBICC]]></acronim><duration></duration><status>Prekinut</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, </scie_field_hr><scie_field_en>Physics, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>17802</team_members_id><team_members_names><![CDATA[ Doktorand: Roman Kosanović ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[MeV Ion Beams, Stopping Power, Ion Beam Modification of Materials, Ion Beam Analysis, Ion Beam Channeling, IBIC, RBS, PIXE, PIGE]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[In the recent years MeV ions have been extensively utilized as indispensable powerful tool in a wide range of materials science research. Ions are very efficient in creating numerous ionizations on their path through the material by ejecting/exciting electrons (electron stopping) and in creating vacancies by recoiling the whole atoms (nuclei) from their lattice sites (nuclear stopping). Therefore, irradiation of materials with energetic ion beams is considered as a) an efficient tool to alter materials physical, chemical, electrical and optical properties and b) a sensitive probe that can be used to characterise materials using some of the Ion Beam Analysis (IBA) methods. Understanding of complicated dynamical processes that lead to structural modifications of materials requires the knowledge of experimental data related to kinematics of defects during and after irradiation. Therefore the goal of the present proposal is experimental study of the time evolution of radiation induced changes induced by energetic (MeV) ion beams and their characterization using the RBI Tandem Accelerator Facility. The focus will be on studying: (i) influence of electronic stopping and related nanostructuring of materials by ion track methodology; (ii) influence of nuclear stopping to radiation damage and amorphization in crystals, including crystalline and functional materials of interest for future fusion reactors; (iii) charge transport properties in crystalline materials, focusing on novel semiconductor materials for radiation detection.  Experimental methodology relies mostly on the unique RBI dual-beam end station that will be used for ion beam irradiations and simultaneous characterization of induced changes using IBA methods like RBS and PIXE in channelling mode, ERDA, NRA and PIGE, as well as IBIC (Ion Beam Induced Charge).]]></summary_en></project><project>
<id>2517</id><title_hr><![CDATA[Uloga receptora autofagije u selektivnom uklanjanju mitohondrija]]></title_hr><title_en><![CDATA[]]></title_en><user_id>62</user_id><user_firstLast_name>Ivana Novak Nakir</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2014-06</proposal_call><code>DOK-2014-06-9538</code><acronim><![CDATA[AutoMito]]></acronim><duration>08.01.2015 - 26.05.2021</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Splitu, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Split School of Medicine]]></institution_en><team_members_id>17855</team_members_id><team_members_names><![CDATA[ Doktorand: Mija Marinković ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[autophagy, mitochondria, mitophagy, receptor, neurodegeneration, cancer]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Autophagy is cellular degradation pathway essential for cell survival, development and differentiation. Its digestive property has been shown important in different pathologies including cancer, neurodegeneration and pathogen removal. Discoveries of specific autophagy receptors have opened a new chapter in the autophagy field. Of great interest is the removal of damaged or excess mitochondria through specialized autophagy- mitophagy. Together with colleagues, I have identified and characterized mitochondrial proteins Nix/Bnip3L and Bnip3 as a mitophagy receptors for recruiting the autophagic machinery to damaged mitochondria and help their elimination (Novak et al, 2010; Zhu et al, 2013). We demonstrated that receptors mediate mitochondrial clearance during reticulocyte differentiation. Our goal is to further study autophagy receptors and proteins associated with mitochondrial clearance to better understand the role of mitophagy and its mechanism. We will study: (1) phosphorylation and dimerization of receptors and the consequences of this events on mitophagy progression; (2)factors that regulate tight connection of apoptosis and mitophagy; (3)potential interplay between mitophagy receptors and other mitophagy-related proteins, like  E3-ligase Parkin and kinase PINK1; (4)the effects of mitophagy on cancer development. To reach our goals we will use established methodology in our laboratories including protein identification and interaction techniques (Western blot, IP, GST-pull down, RNAi), immunofluorescent microscopy, mass spectrometry, ITC and NMR. All experiments will be performed using cultured cells. This project proposal has a high capacity to generate very interesting data with high possibility for publications in top scientific journals. Fundamentally, generated data will help to understand the physiological and pathological conditions, such as neurodegeneration and cancer and allow us to manipulate mitophagy to fight diseases.]]></summary_en></project><project>
<id>2519</id><title_hr><![CDATA[Europski registar za djecu oboljelu od upalnih bolesti crijeva]]></title_hr><title_en><![CDATA[]]></title_en><user_id>5694</user_id><user_firstLast_name>Sanja Kolaček</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2014-06</proposal_call><code>DOK-2014-06-7791</code><acronim><![CDATA[]]></acronim><duration></duration><status>Prekinut</status><financ_value></financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Kliničke medicinske znanosti, </scie_field_hr><scie_field_en>Clinical sciences, </scie_field_en><institution_hr><![CDATA[Ništa od navedenog]]></institution_hr><institution_en><![CDATA[Nothing from this list]]></institution_en><team_members_id>17781</team_members_id><team_members_names><![CDATA[ Doktorand: Lana Njavro ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>2520</id><title_hr><![CDATA[Razvoj voltametrijskih metoda za karakterizaciju prirodnih antioksidansa]]></title_hr><title_en><![CDATA[]]></title_en><user_id>442</user_id><user_firstLast_name>Šebojka  Komorsky-Lovrić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2014-06</proposal_call><code>DOK-2014-06-2282</code><acronim><![CDATA[DVMCNA]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, </scie_field_hr><scie_field_en>Chemistry, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>17762</team_members_id><team_members_names><![CDATA[ Doktorand: Lara Čižmek ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[voltammetry, antioksidans, radicals, squave wave, simulations]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Oxidant is an ion or a compound that reacts with a certain component of a living cell and oxidizes it. The reactive oxygen species produced in cells include hydrogen peroxide, hypochlorous acid, hydroxyl radical and superoxide anion. Antioxidant is a foreign substance that reacts with the oxidant faster than the components of the cell. An imbalance between oxidants and antioxidants in favour of the oxidants is termed oxidative stress. Antioxidants act as free radical scavengers and therefore can lower the risk of numerous degenerative diseases by preventing damages caused by free radicals. Fruits and vegetables are the major sources of antioxidants in human diet. Several natural compounds found in food, such as polyphenols, vitamins A and E, and some carotenoids, have been found to show excellent antioxidant activity. Chlorophylls and their derivatives have also been reported to possess this activity. However, literature is still scarce regarding their antioxidant properties. It is known that the amount of each antioxidant in fruits, vegetables and their derivatives is strongly influenced by numerous factors such as agro-technical processes, environmental conditions, processing factors and storage conditions. Continuous monitoring of antioxidant capacity of plant-based foods through different phases, from cultivation to storage, is needed to maintain or even improve the beneficial properties of food. The goal of this project is to develop several cyclic multi-pulse voltammetric techniques for the characterization of natural antioxidants and to apply them in routine analysis of food quality. Experimental results will be explained by the comparison with the theoretical simulation of responses of various electrode mechanisms of independent and conjugated multiple redox centers.]]></summary_en></project><project>
<id>2521</id><title_hr><![CDATA[Aproksimacija ovisna o konfiguraciji u nelinearnoj analizi konstrukcija metodom konačnih elemenata]]></title_hr><title_en><![CDATA[]]></title_en><user_id>527</user_id><user_firstLast_name>Gordan Jelenić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2014-06</proposal_call><code>DOK-2014-06-9680</code><acronim><![CDATA[CANFAS]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Temeljne tehničke znanosti, </scie_field_hr><scie_field_en>Basic engineering sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Građevinski fakultet u Rijeci]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Civil Engineering]]></institution_en><team_members_id>17756</team_members_id><team_members_names><![CDATA[ Doktorand: Sara Grbčić ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[non-linear structural analysis, finite-element method, configuration-dependent approximation, beams, shells, dynamics]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[This proposal explores the configuration-dependent interpolation as a novel, unorthodox and remarkably promising expansion of the framework within which the non-linear finite-element method has been traditionally contained. The basic idea underlying the project stems from an apparent disparity between the rather advanced extensions of the traditional linear finite-element principles to non-linear problems and the fact that the key finite-element concept – that of interpolation of the unknown functions – is surprisingly kept mostly constant, i.e. configuration-independent. Enabling the finite-element approximation to become configuration-dependent is motivated by the existing need to improve the current non-linear finite-element procedures, in particular for mechanical problems defined on non-linear manifolds. This principle is presented as the general concept providing viable novel development paradigm with obvious benefits for a wider class of mechanical problems. The configuration-dependent approximation to be designed shall obey the essential convergence requirements, with its extra flexibility (arising from the potential of the new approximation to vary with the configuration) employed to improve the solution in some clearly defined manner. In particular, during the design process, the following two basic principles will be consistently adhered to:(i) In the limiting case where the non-linear mechanical problem becomes linear, the configuration-dependent approximation sought must coincide with a known reference interpolation for linear analysis.(ii) In a general non-linear situation, the configuration-dependent approximation should preserve a set of selected mechanical or mathematical properties of equilibrium or motion defined beforehand.In this way, a variety of finite-elements for static and dynamic analysis will be derived.]]></summary_en></project><project>
<id>2522</id><title_hr><![CDATA[Thymistem, (FP7- Health 2013.1.4-1)  ]]></title_hr><title_en><![CDATA[]]></title_en><user_id>498</user_id><user_firstLast_name>Mariastefania Antica</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2014-06</proposal_call><code>DOK-2014-06-2010</code><acronim><![CDATA[]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>17772</team_members_id><team_members_names><![CDATA[ Doktorand: Josipa Skelin ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>2525</id><title_hr><![CDATA[Algoritmi za analizu slijeda genoma]]></title_hr><title_en><![CDATA[]]></title_en><user_id>1480</user_id><user_firstLast_name>Mile Šikić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2014-06</proposal_call><code>DOK-2014-06-2255</code><acronim><![CDATA[AGESA]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Računarstvo, </scie_field_hr><scie_field_en>Computer sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id>18950</team_members_id><team_members_names><![CDATA[ Doktorand: Robert Vaser ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[genome sequence, DNA sequence alignment, RNA-seq mapping, database search, algorithms, GPU]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Twenty years ago, sequencing the human genome was one of the most ambitious science projects ever attempted. Today, DNA and RNA sequencing are now key components of research carried out in many laboratories. The total amount of available genomic data is increasing approximately tenfold every year, a rate much faster than Moore’s Law for computational processing power. The exponential growth of genomic datasets leads to a situation, where computing power becomes a critical issue.The overarching goal of the project is to develop accurate, fast algorithms and tools for analyzing the whole genome-sequencing data. The emphasis of the project is on the output data from the third-generation of sequencing machines that produce longer, more error-prone sequence reads. The basis of the project are sequence alignment algorithms, graph algorithms and signal processing methods. They will be implemented for DNA sequence assembly, sequenced RNA data and sequence similarity database search. The algorithms should feasibly handle data obtained from mammalian and plant genomes (sizes greater than one billion base pairs). Special emphasis will be put on multi-core, many-core and intra-core parallelism. Additionally, the algorithms should provide good scalability over the available underlying computational architecture. All implementations of algorithms will be performed in C/C++. The research will result in the development of novel algorithms tailored to specifications of current and future long-read sequencing data. The implemented methods will further the state-of-the-art of sequence similarity database search, RNA-seq mapping and DNA assembly, ideally providing researchers with methods that return results in feasible time with limited computational resources. This, in turn could affect the current practices of genomic research; help designing new medical strategies and enable faster and more accurate analyses and diagnoses. ]]></summary_en></project><project>
<id>2526</id><title_hr><![CDATA[MOLEKULARNI MEHANIZMI POVEĆANJA OSJETLJIVOSTI NA PROTUTUMORSKE LIJEKOVE STANICA KARCINOMA DOJKE I MELANOMA ČOVJEKA UTIŠAVANJEM INTEGRINA]]></title_hr><title_en><![CDATA[]]></title_en><user_id>1211</user_id><user_firstLast_name>Andreja Ambriović Ristov</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2014-06</proposal_call><code>DOK-2014-06-9922</code><acronim><![CDATA[INSILCELL]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Biologija, </scie_field_hr><scie_field_en>Biology, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>420</team_members_id><team_members_names><![CDATA[ Doktorand: Ana Dekanić ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[breast cancer, melanoma, signalling pathways, anticancer drug resistance, focal adhesion, migration, invasion]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[The recognition of molecular mechanisms involved in drug resistance may improve basic knowledge of signalling pathways involved in resistance to anticancer drugs and also improve outcomes in patients with drug-resistant cancers that have poor prognosis, such as triple negative breast cancer (TNBC) and metastatic melanoma. Integrins are cell surface molecules that mediate sensitivity to anticancer drugs, migration and invasion, and therefore represent a suitable target for therapy. This proposal investigates the molecular mechanism behind knockdown of integrins alpha v beta 3, alpha v beta 5, alpha v beta 6, alpha 3 beta 1, alpha 4 beta 1 and alpha 5 beta 1 using integrin subunit specific siRNAs (beta 3, beta 5, beta 6, alpha v, alpha 3, alpha 4 or alpha 5) and the ability of such a treatment to sensitise TNBC and melanoma cell lines to anticancer drugs paclitaxel, vincristine and cisplatin. Our next goal is to identify how specific integrin knockdown influences cell migration and invasion. The focal adhesions (FA) are sites of attachment between cells and extracellular matrix which may mediate differential cell responses by variation of FA protein composition. Therefore, the FA protein composition will be investigated before and upon integrin silencing using proteomics methodology. We will monitor formation and temporal evolution of FA in living cells during spreading or migration using reflection interference contrast microscopy (RICM). On the basis of these data, several signalling pathways will be proposed and their involvement in sensitivity to anticancer drugs, migration and invasion will be experimentally verified. Our data will contribute to the knowledge on integrin signalling pathways, structure and function of focal adhesions. The understanding of integrin pathways involved in sensitivity to anticancer drugs, migration and invasion processes may provide novel insights into biology of these cancer cells and identify new target molecules in TNBC or melanoma.]]></summary_en></project><project>
<id>2527</id><title_hr><![CDATA[Life-Strategies and Survival Strategies of Households and Individuals in South-EastEuropean Societies in the Times of Crisis]]></title_hr><title_en><![CDATA[]]></title_en><user_id>7730</user_id><user_firstLast_name>Inga Tomić-Koludrović</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2014-06</proposal_call><code>DOK-2014-06-7620</code><acronim><![CDATA[]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Sociologija, </scie_field_hr><scie_field_en>Sociology, </scie_field_en><institution_hr><![CDATA[Institut društvenih znanosti Ivo Pilar]]></institution_hr><institution_en><![CDATA[Institute of Social Sciences Ivo Pilar in Zagreb]]></institution_en><team_members_id>17800</team_members_id><team_members_names><![CDATA[ Doktorand: Augustin Derado ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>2528</id><title_hr><![CDATA[Elektrokemijski superkondenzator visoke snage i velikog sadržaja energije za primjenu u električnim vozilima]]></title_hr><title_en><![CDATA[]]></title_en><user_id>961</user_id><user_firstLast_name>Zoran Mandić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2014-06</proposal_call><code>DOK-2014-06-7033</code><acronim><![CDATA[ESUP-CAP]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Kemijsko inženjerstvo, </scie_field_hr><scie_field_en>Chemical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet kemijskog inženjerstva i tehnologije]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Chemical Engineering and Technology]]></institution_en><team_members_id>17810</team_members_id><team_members_names><![CDATA[ Doktorand: Denis Sačer ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[Supercapacitors, electrochemical energy sources, electric vehicles, renewable energy, carbon electrodes, conducting polymers]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[In the context of renewable and “clean” energy sources, the main aim of the present project is to provide a technology output for the novel, high power-high energy electrochemical supercapacitor device that could be implemented in hybrid electric vehicles. The project addresses an interdisciplinary research and combines fundamental and applied research activities in chemical, electrical and environmental engineering fields. The highest possible scientific and technological impact of the project is supposed to be ensured by joining of the human and experimental resources of several different Croatian’s groups. The novel, high power-high energy electrochemical supercapacitor device will be based on hybridization of two different types of electrodes (double-layer and pseudo-capacitive) in a respective electrolyte. Various forms of carbon and carbon based binary and ternary composites with transition metal oxides and/or conducting polymers will be tested as negative and positive electrodes, respectively. For being competitive in the area of energy storage, the tested electrodes should fulfil the requirements of high specific capacitance, long cycle-life, good charge/discharge efficiency, low self discharge and adequate operating voltage. The project is planned to be realized mostly on the basis of fundamental experimental research directed towards increasing of the basic knowledge comprising choice of material, proper design of electrodes and careful elucidation of all underlying physical and chemical processes at active electrode/electrolyte interfaces. The results of fundamental experimental research will be utilized for selection of proper electrodes, their arrangement into electrochemical supercapacitor device, optimization of device to the energy content and power ability, testing of device in practical environment and implementation of device into hybrid electrical vehicle. ]]></summary_en></project><project>
<id>2530</id><title_hr><![CDATA[Epigenetička regulacija glikozilacije immunoglobulina G]]></title_hr><title_en><![CDATA[]]></title_en><user_id>5416</user_id><user_firstLast_name>Vlatka Zoldoš</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2014-06</proposal_call><code>DOK-2014-06-1892</code><acronim><![CDATA[EpiGlycoIgG]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Biologija, </scie_field_hr><scie_field_en>Biology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>17847</team_members_id><team_members_names><![CDATA[ Doktorand: Vanja Tadić ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[DNA methylation, Epigenetics, Histone modifications, IgG, Protein glycosylation, TALENS]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[IgG is one of the main effectors of the immune system. Contrary to antigen binding properties which are defined by nucleotide sequence for its Fab part, effector functions of IgG are mostly regulated by Fc glycosylation, which is regulated by complex interplay of dozens of genes in the IgG glycosylation pathway and different environmental factors. Different clones of B lymphocytes have defined patterns of glycosylation, indicating temporal stability in the glycosylation pathway. DNA CpG methylation is the most stable epigenetic modification and is thus the most prominent candidate for “fixation” of the IgG glycosylation profile in different clones. Our past and current genome wide association studies (GWAS) are identifying complex genetic network which regulates IgG glycosylation. In this project we will use several complementary experimental approaches to identify genes and epigenetic regulatory mechanisms which regulate IgG glycosylation. IgG glycosylation is relevant in numerous diseases, including autoimmune diseases, inflammatory diseases and cancer. Several epigenetic drugs are already used to treat cancer, and many others are developing. Understanding of the role of the epigenetic regulation in IgG glycosylation will provide new targets for the development of new epigenetic drugs and new biomarkers for patient stratification. ]]></summary_en></project><project>
<id>2532</id><title_hr><![CDATA[Bioinspirirani materijali - mehanizmi nastajanja i interakcija]]></title_hr><title_en><![CDATA[]]></title_en><user_id>922</user_id><user_firstLast_name>Damir Kralj</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2014-06</proposal_call><code>DOK-2014-06-2469</code><acronim><![CDATA[Bio-Mat-Form]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, </scie_field_hr><scie_field_en>Chemistry, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>17878</team_members_id><team_members_names><![CDATA[ Doktorand: Lara Štajner ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[Biomineralization, Calcium Phosphates, Calcium Carbonates, Precipitation, Model organic molecules]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Prosperity of modern society at large extent relies on the design of new and advanced materials. Many classes of organic, inorganic or hybrid materials are produced by process of precipitation (crystallization) in which the size, morphology, chemical and structural composition could be tuned by the strict control of formation conditions. Process by which living organisms produce hard tissues is known as biomineralization and such tissues are, actually, the organic-inorganic composites. In comparison to their geological analogues, biominerals have the superior mechanical and chemical properties that are a consequence of just a minor presence of extracellular matrix proteins or polysaccharides, as well as of the specific confined environment in which the process occur. In addition, such materials are produced from aqueous systems, chemically neutral precursors, at low temperature and pressure, thus inspiring the scientists investigating the biomimetic syntheses routes for design of functional materials for advanced application.In order to contribute to the understanding of basic interactions between the mineral phases and complex macromolecules, underlying biomineralization, we propose the investigations in which the representative inorganic salts (calcium carbonates & phosphates) will be precipitated in a presence of simple and representative organic molecules (acidic and hydrogen bonding amino acids and custom-designed small peptides) while the complexity of systems will be systematic increased by confining the precipitation in polysaccharide hydrogel or synthetic vesicular microenvironment. Particular attention will be paid on a role of the amorphous and other precursor phases on formation of stable modifications relevant for biomineralization. Besides the precipitation kinetic analyses, the advanced characterization techniques (HR-TEM, EPR, confocal microscopy) will be applied in order to reveal the mechanisms of organic molecules – mineral surface interactions.]]></summary_en></project><project>
<id>2534</id><title_hr><![CDATA[Razvoj naprednih energetski učinkovitih struktura upravljanja generatorom sa stalnim magnetima bez mjernog člana ]]></title_hr><title_en><![CDATA[]]></title_en><user_id>5949</user_id><user_firstLast_name>Damir Sumina</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2014-06</proposal_call><code>DOK-2014-06-8519</code><acronim><![CDATA[PMGEFC]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Elektrotehnika, </scie_field_hr><scie_field_en>Electrical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id>17782</team_members_id><team_members_names><![CDATA[ Doktorand: Tin Bariša ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[permanent magnet generator,  wind power generation, back-to-back converter, energy efficiency,  sensorless control,]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Renewable energy sources have been attracting great attention due to the cost increase, limited reserves and advanced environmental impact on fossil fuels. In the meantime, technology advancements, cost reduction and governmental incentives have made some renewable energy sources more competitive in the market. Among them, wind energy is the one of the fastest growing renewable energy sources. The conversion of the wind energy into electric energy is of a multidisciplinary nature, involving aerodynamics, mechanical systems, electric machines, power electronics, control theory, and power systems.The main goal of this project is to establish new research group which will improve the quality, performance and competitiveness of industrial sector in the field of wind power generation. The research group has already participated in the project for the development of advanced control structures for induction generator connected via back-to-back-converter to the grid in wind turbine application. As a step forward in innovation, research and development the research focus is set on permanent magnet synchronous generator (PMG) parameter identification, estimation of PMG rotor position using high frequency signal injection and speed estimation. Also, focus is on energy efficient based control method such as model predictive control of PMG. Advanced sensorless control algorithms for PMG will be developed and experimentally verified on the industrial laboratory model. Basic infrastructure for implementation and verification of developed algorithms exists in the Laboratory and for testing of advanced control structures on PMG laboratory model needs to be further upgraded. The final result will be the capability of research group for future cooperation with industrial partners for development of wind power generator systems and other generation systems.]]></summary_en></project><project>
<id>2535</id><title_hr><![CDATA[Postupci strojnog učenja za dubinsku analizu složenih struktura podataka]]></title_hr><title_en><![CDATA[]]></title_en><user_id>19111</user_id><user_firstLast_name>Ivica Kopriva</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2014-06</proposal_call><code>DOK-2014-06-5945</code><acronim><![CDATA[DescriptiveInduction]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Računarstvo, </scie_field_hr><scie_field_en>Computer sciences, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>17767</team_members_id><team_members_names><![CDATA[ Doktorand: Maria Brbic ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[machine learning, knowledge discovery, structured data, rule learning, FPGA]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[ Induction is a process of knowledge extraction from information contained in data. In our work we will concentrate on descriptive induction whose goal is to construct knowledge that enables human understanding of the data. Included are techniques for construction of user-interpretable models, segmentation of the corpus of examples, and detection of outliers. The methodology is relevant for the computer science fields known as intelligent data analysis, knowledge discovery from data, and data mining. At Rudjer Boskovic Institute we are developing machine learning algorithms for more than 15 years and we have successfully applied them in various domains including chemistry, biology, medicine, social sciences, economics, and manufacturing. With this project we want to extend the existing methodology and to implement novel techniques able to cope with data contained in complex structures. The main topic will be spatio-temporal structures but we will work also with networks of data, relational databases, and data contained in ontologies. Previous experience clearly demonstrates that complete transformation of information contained in structured data into a form that may enter the induction process is not a simple task. Our goal is to develop and implement systematic and general approaches for this conversion. The consequence will be explosion of generated data that must enter into the process of induction. Therefore, the second goal will be implementation of efficient algorithms for descriptive induction. The work includes development of novel algorithms for clustering and outlier detection in sets of unclassified examples and implementation of hardware for fast execution of rule learning algorithms. The third goal is application and evaluation of implemented algorithms in various real-life domains. The success of the complete project will be measured by the quality and usefulness of knowledge obtained in these applications.]]></summary_en></project><project>
<id>2537</id><title_hr><![CDATA[Uvjeti, resursi, neprijatelji i bioraznolikost: Sile koje oblikuju morske zajednice u plitkom Jadranskom moru]]></title_hr><title_en><![CDATA[]]></title_en><user_id>1269</user_id><user_firstLast_name>Stewart Schultz</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2014-06</proposal_call><code>DOK-2014-06-2216</code><acronim><![CDATA[COREBIO]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Biologija, </scie_field_hr><scie_field_en>Biology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zadru]]></institution_hr><institution_en><![CDATA[University of Zadar]]></institution_en><team_members_id>17825</team_members_id><team_members_names><![CDATA[ Doktorand: Dubravko Pejdo ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[community ecology, fish, Posidonia, habitat, monitoring]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[This project is an investigation of the major drivers of fish community structure in the shallow Adriatic Sea of Croatia.  This information is crucial for the sustainable, scientific management of coastal ecosystems, as required by EU instruments such as the Habitats Directive, Marine Strategy Framework Directive, Water Framework Directive, and the Common Fisheries Policy.   The major questions asked are 1) What are the ecological baselines in Croatia in community structure?  2) How does anthropogenic activity (harvesting, coastal development) shift community structure from baseline?  3) How do marine protected areas maintain functional communities?  4) How is community structure changing over time?   We will investigate these questions using innovative, non-destructive techniques for quantifying fish abundance and size distribution, and benthic habitat quality.  These techniques include lure-assisted, underwater visual census which was originally developed in the Schultz laboratory; baited, underwater video; and DGPS-assisted, towed underwater video.  EU policies require that non-destructive methods for assessment and monitoring replace destructive harvest-based methods currently in widespread use, and these methods are among the most scientifically supported non-destructive methods currently available.  These methods will be used to quantify fish community structure and benthic habitat at all major MPAs and former MPAs in Croatia, to compare communities within MPAs to matched locations outside MPAs.   Matched locations will be chosen to test for specific anthropogenic drivers of community structure, such as high fishing pressure, coastal development, marine tourism, aquaculture, and terrestrial runoff.  These results will advance our basic understanding of coastal ecosystems, and will be crucial for satisfying Croatia&#39;s responsibilities as an EU citizen in MPA construction, management, and monitoring of marine resources.]]></summary_en></project><project>
<id>2538</id><title_hr><![CDATA[Promjenjivost Sunca i zvijezda]]></title_hr><title_en><![CDATA[]]></title_en><user_id>4850</user_id><user_firstLast_name>Bojan Vršnak</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2014-06</proposal_call><code>DOK-2014-06-8294</code><acronim><![CDATA[SOLSTEL]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, </scie_field_hr><scie_field_en>Physics, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Geodetski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Geodesy]]></institution_en><team_members_id>6152</team_members_id><team_members_names><![CDATA[ Doktorand: Mateja Dumbović ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[solar activity, space weather, climate, heliosphere, sun-like stars, variable stars, binary stars, accretion discs, exoplanets, substellar companions]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[The proposed four-year project connects solar physics, solar-terrestrial physics, heliospheric physics, space weather & climate, geophysics, and stellar physics. It is based on empirical/interpretative, theoretical/analytical, and theoretical/numerical approach, and concerns all astrophysical problems currently in focus of the research at the Hvar Observatory (HO) of the Faculty of Geodesy of the University of Zagreb. Thus, the proposed program is in a great deal determined by, and directed towards, effective exploitation of the observational capacities and manpower of HO. The project is divided into five thematic topics: 1) solar activity and eruptive phenomena in the solar atmosphere; 2) solar-activity impact on the Earth; 3) stellar eruptive activity; 4) radiation processes in solar and stellar atmospheres; 5) exoplanets and substellar companions. In the first topic special attention is devoted to the research of the physics of coronal mass ejections and solar flares, since they drive the most intense geomagnetic storms, as well as changes of radiation belts and ionosphere. The central issue of the second topic is the influence of the solar variability on the Earth climate. The third topic is devoted to stellar eruptive magnetic-field activity, aiming to provide a better understanding of the long-term evolutionary aspect of the solar activity. The fourth topic is an important subject not only for astrophysics, but also for plasma physics in general, since it provides an alternative view on plasma instabilities and emission processes. The fifth topic is a timely astrophysical theme, since it provides new insights into physics of planetary systems, and is very important subject for understanding of the solar-system formation and evolution.]]></summary_en></project><project>
<id>2540</id><title_hr><![CDATA[Nano-mreže kvantnih točaka u staklima: Od samouređenja do pretvorbe energije i pohrane vodika]]></title_hr><title_en><![CDATA[]]></title_en><user_id>1362</user_id><user_firstLast_name>Maja Buljan</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2014-06</proposal_call><code>DOK-2014-06-4610</code><acronim><![CDATA[NanoDeSign]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, </scie_field_hr><scie_field_en>Physics, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>17815</team_members_id><team_members_names><![CDATA[ Doktorand: Nikolina Nekić ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[Quantum dots, Self-assembly, Magnetron sputtering, Quantum dot crystal, Hydrogen storage, Energy conversion, Solar cell, Ion-beam irradiation]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[The main goal of the project is to investigate the capabilities of the recently developed materials based on self-assembled quantum dots organized as nano-networks in glass matrices for application in energy-conversion and Hydrogen-storage devices. Two new self-assembly processes of Ge quantum dots in dielectric amorphous matrices and consequently novel material types have been discovered recently by our group.  We have performed intensive investigation of their structural properties since then, and we had found that they appear in many different shapes, internal structures and ordering types. One material can store large amounts of Hydrogen. However, only properties of Ge and SiGe quantum dots have been investigated, while all other materials and their properties are completely unknown. These materials are theoretically very suitable for applications, especially in photo-electric conversion and energy storage, so the investigations of their properties related to the applications are also very important.We intend to form a group which will be excellent in production, characterization and application of these materials. Precisely, we intend to (i) further investigate the observed self-assembly processes and develop new material types with interesting or extraordinary structural properties; (ii) determine the basic optical and electrical properties of these materials and (iii) produce simple devices based on these materials for energy conversion and storage.We expect preparation of new, applicative materials with exceptional properties, observation of unusual effects caused by specific structure, and preparation of efficient thin-film coatings for conversion and storage of Sun energy. These results could be of great relevance for the production of super-efficient energy-converting window glasses, as the method that we use for the preparation (magnetron sputtering deposition), is a standard technique for production of window coatings and low-emissivity glasses.]]></summary_en></project><project>
<id>2541</id><title_hr><![CDATA[Transporna, magnetska i termodinamička svojstva odabranih anorganskih i organskih materijala]]></title_hr><title_en><![CDATA[]]></title_en><user_id>5009</user_id><user_firstLast_name>Ivan Kokanovoć</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2014-06</proposal_call><code>DOK-2014-06-6755</code><acronim><![CDATA[TRANMAGTHERPROMAT]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, </scie_field_hr><scie_field_en>Physics, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>17743</team_members_id><team_members_names><![CDATA[ Doktorand: Filip Orbanić ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[Superconductivity, topological insulators,  metallic glasses,  nanocrystalline alloys, conducting polymers, ]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[This Project is centred on the physics of selected YBCO single crystals, HTSC, topological insulators, TI, metallic glasses, MG, nanocrystalline alloys, NCA, and conducting polymers, CP, and investigation of their transport, thermodynamic, thermoelectric, magnetic, superconducting and structural properties. The primary issue addressed in the field of HTSC is the existence of electron pockets in low magnetic fields   caused by charge density waves, CDW, in pure YBa2Cu3O6+x single crystals. We propose to measure the magnetisation and specific heat in the whole doping range  to extract the total density of states at the Fermi level and thereby determine the number of pockets.  At the same time we will look for thermodynamic signatures of the CDW phase transitions.  Other unresolved controversies which will be investigated include the doping evolution of the mean-field upper critical field and whether Gaussian superconducting fluctuations can account for the magnetisation and specific heat of both underdoped and overdoped YBa2Cu3O6+x single crystals at T>Tc. In the field of TI, we will investigate the thermoelectric properties of bismuth based chalcogenide (BiSbTeSe2) and 3D Dirac semimetals and to find the evidence of the linear dispersion and nontrivial topology of these materials. Our next aim is to achieve ferromagnetism in selected TIs; TlBi(S0.5Se0.5)2, PbSnTe and PbSnSe by doping with Mn or Fe and gain understanding of the mechanism responsible for the ferromagnetic ordering.   In the field of MG and NCA   the goal is to gain some insight into the glassy structure and mechanism involved in its crystallisation. In the field of organic conductors we intend to investigate PANI-DBSA (DBSA-dodecylbenzenesulfonic acid) thin film samples. A particular emphasis of the research will be the further development of novel apparatus to measure the magnetisation and specific heat of small single crystals which are often of the highest quality.  ]]></summary_en></project><project>
<id>2542</id><title_hr><![CDATA[Dubrovnik: Civitas et Acta Consiliorum, Vizualizacija razvoja kasnosrednjovjekovnog urbanog tkiva]]></title_hr><title_en><![CDATA[]]></title_en><user_id>5998</user_id><user_firstLast_name>Danko Zelić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2014-06</proposal_call><code>DOK-2014-06-6008</code><acronim><![CDATA[DUCAC]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Povijest umjetnosti, </scie_field_hr><scie_field_en>Art history, </scie_field_en><institution_hr><![CDATA[Institut za povijest umjetnosti]]></institution_hr><institution_en><![CDATA[Institute of Art History, Zagreb]]></institution_en><team_members_id>5555</team_members_id><team_members_names><![CDATA[ Doktorand: Matko Matija Marušić ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[new archival data, urban development, changes of tissue, dissemination, comparative perspective, general public, new digital technologies]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[The aim of the DUCAC project is to establish an international, Croatian-Italian group of urban history researchers that would participate in the work, research and discussions within the international community of humanities and social sciences. The project&#39;s main goal is to systematically investigate the unpublished 15th century archival records of Dubrovnik&#39;s three governing bodies (Great Council, Minor council and the Senate) in order to select, gather, interpret and publish data concerning urban spaces and buildings and to examine the relationships between Councils’ deliberations and the urban development. The results would be discussed within the comparative perspective regarding the similar topics of other European towns as well as disseminated within scientific community and general public. These objectives would be established using new digital technologies for the humanities - HGIS interactive database and 3D visual presentations of the related processes.]]></summary_en></project><project>
<id>2543</id><title_hr><![CDATA[Uloga biotičkih čimbenika na vitalnost poljskoga jasena (Fraxinus angustifolia Vahl.) u poplavnim šumama Hrvatske]]></title_hr><title_en><![CDATA[]]></title_en><user_id>1128</user_id><user_firstLast_name>Davorin Kajba</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2014-06</proposal_call><code>DOK-2014-06-1443</code><acronim><![CDATA[FRAXINPRO]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Šumarstvo, </scie_field_hr><scie_field_en>Forestry, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet šumarstva i drvne tehnologije]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Forestry and Wood Technology]]></institution_en><team_members_id>17430</team_members_id><team_members_names><![CDATA[ Doktorand: Ivan Andrić ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[Fraxinus angustifolia, vitality, biotic agents, floodplain forests, modelling]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Close to half of the Croatian flood plain forests (67 470 ha) are represented by narrow-leaf ash (Fraxinus angustifolia), covering 29 748 ha in major river basins. Respective welfare value of these forests amount to 6,4 billion €, 2,8 billion € being attributed exclusively to ash forests. Growing stock in narrow-leafed ash forests reaches 4,3 million m3, binding 11,8 million tons of carbon dioxide acting as an important carbon sink depository. Natural and artificial regeneration of ash stands is under direct impact of numerous biotic and abiotic factors, many of which seriously hamper the viability of ash. Insect pests, pathogenic fungi, large game ungulates and ruminantes and small rodent populations play dominant role in the complex processes of tree decline and stand deterioration. Additionally, in the course of recent Europe-wide dramatic spread of newly identified lethal disease on ashes (Chalara fraxinea), introduction of a highly damaging Emerald Ash Borer (Agrilus planipennis) on the eastern borders of Europe, and increased frequency of climatic extremes urge the need to intensify the research of this phenomena. Through an integrated, multidisciplinary approach, in the course of 4 years, the proposed research project targets on several critical aspects of aforementioned biotic detrimental factors analyzing them in the given area and time and aiming to provide a multitude of new details on the mechanisms of their impact. Modern methodological approach covers the following major research topics: presence, local impact and ash disease spread and host resistance tests; additive impact of ash defoliators in the course of recent decline and possibility to manage their populations via entomopathogenic organisms; the impact of small rodents on tree regeneration, acting also as an important human diseases reservoir; negative impact of large game in ash regeneration; geospatial and temporal analysis of major biotic influences in given forest communities. ]]></summary_en></project><project>
<id>2544</id><title_hr><![CDATA[Histološka, MRI i analiza genske ekspresije reorganizacijskih procesa u medijalnom (limbičkom) zidu ljudskog mozga tijekom razvitka]]></title_hr><title_en><![CDATA[]]></title_en><user_id>3523</user_id><user_firstLast_name>Mario Vukšić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2014-06</proposal_call><code>DOK-2014-06-1969</code><acronim><![CDATA[MEDCEREB]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb School of Medicine]]></institution_en><team_members_id>17812</team_members_id><team_members_names><![CDATA[ Doktorand: Vinka Kovačević ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[subplate, marginal zone, human brain development, immunohistochemistry, gene expression, in situ hybridization, MRI analysis, hippocampus, cingulum]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[The salient feature of the human fetal cortex is the presence of the subplate zone (SP), a prominent, synapse rich compartment composed of „waiting“ afferents, loosely arranged axons, synapses, growth cones, migratory neurons, glial cells and extraordinary amount of extracellular matric molecules (ECM). The medial (limbic) cortical regions (areas involved in emotion and memory functions) develop a different laminar structure in comparison with lateral cortical regions. Unlike the lateral cortex, where the SP is a major site of neurogenetic events, in the medial archicortex marginal zone (MZ) seems to be a key zone for early molecular neuronal interactions, synaptogenesis and patterning of growing pathways. The goal of this project is to correlate developmental reorganization of major cellular (cell bodies, growing axons) components of the SP and the MZ in developing medial wall of the human cerebrum (cingulum, hippocampus, amygdala) by combining immunochistochemistry, in situ hybridization, transcriptome analysis with in vivo/in vitro MRI. Histological analysis wiil be performed on postmortem human brains, ranging from 10 postconceptional weeks (POW) to 6.5 years, to analyze the expression patterns of different developmentally regulated proteins in relation to synaptic, laminar, neuronal, glial and ECM development. These results will be correlated with in vivo/in vitro MRI findings obtained in age-matched fetuses, infants and children. In addition, we will also analyze publicly available gene expression database (Kang et al., 2011) to investigate the relationship between structural changes and spatio-temporal expression of specific candidate genes. For the selected candidate genes we will perform in situ hybridization and immunocytochemistry in order to elucidate in which cells are these genes expressed. The obtained data will be used for setting the baseline for studying developmental abnormalities characteristic for diverse neurological disorders]]></summary_en></project><project>
<id>2545</id><title_hr><![CDATA[Uloga disfunkcije lizosoma na nastanak neurodegenerativnih bolesti]]></title_hr><title_en><![CDATA[]]></title_en><user_id>4828</user_id><user_firstLast_name>Silva Katušić Hećimović</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2014-06</proposal_call><code>DOK-2014-06-9815</code><acronim><![CDATA[]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>17865</team_members_id><team_members_names><![CDATA[ Doktorand: Kristina Dominko ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>2546</id><title_hr><![CDATA[Kruženje sumpora i ugljika u morskom i slatkovodnom okolišu]]></title_hr><title_en><![CDATA[]]></title_en><user_id>287</user_id><user_firstLast_name>Irena  Ciglenečki-Jušić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2014-06</proposal_call><code>DOK-2014-06-7023</code><acronim><![CDATA[SPHERE]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, </scie_field_hr><scie_field_en>Chemistry, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>17873</team_members_id><team_members_names><![CDATA[ Doktorand: Ana  Cvitešić ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[sulphur speciation, organic matter properties, nanoparticles in water environment, aerosols, global climate changes, extreme events, euxinia  ]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[The SPHERE aims to study sulphur (S) and carbon (C) dynamics between different environmental compartments (atmosphere, water, sediment, biota) of the sea- and fresh-water environment including distribution between organic, inorganic, dissolved, colloidal and nanoparticulate fractions. S and C cycles in the aqueous environment are recognized as important factors for regulating global climate. Nowadays, human activities have vastly affected the S and C cycles. The aquatic ecosystem responses to likely changes in physical, chemical and socio-economic forcing induced by global climate changes, including warming, acidification, biodiversity modifications as well changes in frequency of extreme events (flooding, dust input, hypoxia-anoxia appearance) and by growing anthropogenic pressures will be considered under SPHERE. Effects of the main natural and anthropogenic forcing (extreme events, eutrophication, global changes) related with S and C dynamics will be studied.The SPHERE objectives are: 1) testing and improving existing methods and development of new methods essential for S and organic matter (OM) characterization in water and atmospheric environment; 2) to estimate exchanges and interactions of S and C with other natural and potentially toxic trace elements within and between the major environmental compartments; 3) to monitor and couple S and C dynamics under extreme events (stratification-destratification, hypoxia-anoxia, extreme atmospheric inputs); 4) to synthesize all obtained data for assessment of ecosystem vulnerability and ecological status, in line with water framework directive and national strategy. The SPHERE will be implemented in the period of 4 years through 5 workpackages: 1) OM properties and dynamics; 2) S speciation and dynamic; 3) S, C interaction with trace metals and importance of chalcogenide nanoparticles; 4) thermodynamic predictions for S and C distribution and dynamics; 5) project management.]]></summary_en></project><project>
<id>2547</id><title_hr><![CDATA[Višenamjensko očitavanje DNA / RNA sekundarne strukture molekularnim kemijskim senzorima]]></title_hr><title_en><![CDATA[]]></title_en><user_id>480</user_id><user_firstLast_name>Ivo Piantanida</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2014-06</proposal_call><code>DOK-2014-06-9225</code><acronim><![CDATA[DNA/RNA-MolSense]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, </scie_field_hr><scie_field_en>Chemistry, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>17784</team_members_id><team_members_names><![CDATA[ Doktorand: Tamara Šmidlehner ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[Molecular sensing, DNA/RNA, fluorescence, oligopeptide, nucleobase]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Molecular recognition of DNA/RNA is of fundamental importance e.g. for gene transcription and regulation, protein synthesis or cell-division. Small molecules selectively targeting specific DNAs or RNAs are therefore highly interesting not only to understand such processes in more detail but also for potential medicinal applications, as sensors or probes for fluorescence based bioimaging as well as for analytical purposes in isolated biosamples. Proposal is based on the collaboration between I. Piantanida and Prof. Dr. C. Schmuck (Germany), joined results in leading chemistry journals (Chemistry, Eur. J; 2010 and 2012, J. Am. Chem. Soc. 2012; Org. Biomol. Chem. 2011, Bioorg. Med. Chem. Lett. 2008). We want to design, synthesize and study highly selective probes for the sensing of DNA/RNA with emphasis on the multi-purpose probes: single molecules able to simultaneously differentiate by several highly sensitive spectrometric methods between the most common secondary structures of ds- DNA/RNA. For increased affinity and selectivity, we plan to test new, more efficient fluorophores (cyanine, phenanthridine, fluorescent nucleobases-Piantanida group) combined with pyrrole-guanidinium cations (Schmuck group) and explore structural diversity of the compounds, by combinatorial approach (solid phase synthesis) based on peptide backbone carrying recognition units/fluorophores. The interaction with DNA/RNA will be studied by Piantanida group (UV/Vis, fluorescence, CD/LD spectroscopy, DSC/ITC microcalorimetry), screening of oligopeptide libraries by IRORI method and atomic force microscopy by Schmuck group. Proposal addresses CSF goals: a) support the collaboration with well-established international leaders, b) foster training of young researchers by work on the INTERNATIONAL research; c) expected results with commercializing potential (novel biochemical probes and/or drugs). The latter feature (c) will be studied within FP7-REGPOT “Innomol” Project at Ruđer Bošković Institute.]]></summary_en></project><project>
<id>2549</id><title_hr><![CDATA[Organske molekule u kondenziranoj fazi: međudjelovanja i modeliranje]]></title_hr><title_en><![CDATA[]]></title_en><user_id>4668</user_id><user_firstLast_name>Hrvoj Vančik</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2014-06</proposal_call><code>DOK-2014-06-1051</code><acronim><![CDATA[ORGMOL]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, </scie_field_hr><scie_field_en>Chemistry, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>19061</team_members_id><team_members_names><![CDATA[ Doktorand: Petar Bibulić ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[reaction mechanisms, solvent effects, solid-state reactions, molecular self-assembly, nitroso compounds, ferrocenes]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[This research will consist of two parallel research pathways. The first will include study of mechanisms of organic reactions in the solid state, and the second will mainly deal with the theoretical study of mechanisms in the solution.Mechanisms of the solid-state processes cannot be interpreted using the established concepts of reaction mechanisms because the phase change plays the crucial role in determining reaction kinetics and the structure of the products. Until now, papers published in this field represent mostly kinetics of phase transformations and descriptions of kinetic data by various mathematical models. As a result, the relationship between such a macroscopic approach and structural changes on the molecular level is still poorly understood. Knowledge about the principles of solid-state reactions is of broad interest, and especially useful to chemists who use solvent-free synthetic methods. In this research, we propose investigations of solid-state reactions based on our recent discoveries and explanations of mechanisms of dimerizations and polymerization of nitroso compounds. Using this established approach and corresponding molecular models, we plan to develop a mechanistic concept of the solid-state reactions, and use it to design novel supramolecular structures.As a starting point of our investigations of organic reaction mechanisms in the solution, we will finish development of our new cluster-continuum solvation model. It will provide us with the most important solute-solvent molecules clusters, allowing the realistic estimates of standard Gibbs energies of involved species and thus prediction of kinetic and thermodynamic data for the examined reactions. The approach will be tested on several model problems, and then used for the analysis of several representative organic mechanisms, including the ones occurring in solids.]]></summary_en></project><project>
<id>2552</id><title_hr><![CDATA[Aerodinamika i aeroelastičnost mostova s ugrađenim cestovnim vjetrobranima]]></title_hr><title_en><![CDATA[]]></title_en><user_id>4960</user_id><user_firstLast_name>Hrvoje Kozmar</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2014-06</proposal_call><code>DOK-2014-06-5445</code><acronim><![CDATA[]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Strojarstvo, </scie_field_hr><scie_field_en>Mechnical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet strojarstva i brodogradnje]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Mechanical Engineering and Naval Architecture]]></institution_en><team_members_id>17884</team_members_id><team_members_names><![CDATA[ Doktorand: Andrija Buljac ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>2553</id><title_hr><![CDATA[Gravitacija i narušenje pariteta]]></title_hr><title_en><![CDATA[]]></title_en><user_id>3313</user_id><user_firstLast_name>Maro Cvitan</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2014-06</proposal_call><code>DOK-2014-06-2072</code><acronim><![CDATA[GRAPARION]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, </scie_field_hr><scie_field_en>Physics, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>17858</team_members_id><team_members_names><![CDATA[ Doktorand: Tamara Štemberga ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[gravity, black holes, parity violation, quantum anomalies, holography, string theory, conformal symmetry, entanglement entropy]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[The effect of parity or charge-parity (CP) violation in gravitational theories has not been extensively studied so far in the literature. Nevertheless this phenomenon might be very important and help explaining the baryon asymmetry of the Universe: our Universe consists of matter, with the negligible amount of antimatter. Despite many attempts a satisfactory explanation for this asymmetry is not yet at hand, although it is generally accepted that the processes responsible for it must violate CP. The qualifying aim of this project is to explore the idea that CP violation may be traced back to gravity. However we believe it is more effective to cope with this problem in the framework of a more general research on parity violating effects in gravity, which we will study by means of modern methods of exploring the gravitational interaction: holography, Kerr black hole horizon-conformal field theory (Kerr-CFT) correspondence, trace anomalies, entanglement entropy, fluid-gravity correspondence. The focus will be in particular on the natural candidates for parity violating gravity processes - the Chern-Simons terms, both pure gravitational and mixed gauge-gravitational ones - using extra-dimension models inspired by the string theory. The expected outcome is a significant increase in understanding the consequences of parity violating gravitational interactions, not only in relation with possible CP violations, but also for other effects, e.g. for corrections to black hole entropy.]]></summary_en></project><project>
<id>2554</id><title_hr><![CDATA[Computational Studies of the Biogenic Amines of the Brain for Targeting Neurological Diseases]]></title_hr><title_en><![CDATA[]]></title_en><user_id>227</user_id><user_firstLast_name>Robert Vianello</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2014-06</proposal_call><code>DOK-2014-06-8651</code><acronim><![CDATA[]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, </scie_field_hr><scie_field_en>Chemistry, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>3091</team_members_id><team_members_names><![CDATA[ Doktorand: Aleksandra  Maršavelski ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>2555</id><title_hr><![CDATA[Numeričko modeliranje složenih elektromagnetskih pojava u transformatorima]]></title_hr><title_en><![CDATA[]]></title_en><user_id>319</user_id><user_firstLast_name>Bojan Trkulja</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2014-06</proposal_call><code>DOK-2014-06-8561</code><acronim><![CDATA[NM_TRAF]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Elektrotehnika, </scie_field_hr><scie_field_en>Electrical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id>17803</team_members_id><team_members_names><![CDATA[ Doktorand: Ana Drandić ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[numerical methods, transformers, insulation systems, lossess, high frequency modelling]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Transformers are crucial devices in efficient and reliable transmission and distribution of electricity. Croatian transformer manufacturers are among a top few in the world, and their annual production is worth about €300 million, what is about 2% of the world production. It is possible to keep this position on the world market only if there is a close collaboration between the academic community and transformer manufacturers. Notable progress in technology of transformers is based on utilization of new materials and application of advanced design methodologies, which incorporate sophisticated numerical methods for modelling of processes in transformers. This project is focused on research and development of advanced numerical techniques for solving various electromagnetic phenomena in transformers and their application in design. Crucial subjects in transformer design are: insulation system, electromagnetic losses and windings. Consequently, researches within this project are organized in three subprojects:1.	New methods for design of insulating systems. The aim of this subproject is to develop new comprehensive numerical method for computation of electric fields within the insulating system.2.	Computation of electromagnetic losses with the aim to develop a new method of estimation of stray losses level of power transformer, as well as the methodology of simultaneous modelling of electromagnetic field, thermal field and fluid dynamics field in transformers.3.	High frequency modelling of windings. The objective of this subproject is to develop fast and accurate procedures for the determination of capacitances, inductances and resistances in high-frequency range. These elements will be used for creating an equivalent lumped-element circuit for determination of voltage stresses along a winding.The overall goal is to reduce dimensions of transformers and to increase their reliability by application of new methods and procedures. ]]></summary_en></project><project>
<id>2556</id><title_hr><![CDATA[Formacija i destrukcija domena u vodenim otopinama]]></title_hr><title_en><![CDATA[]]></title_en><user_id>5374</user_id><user_firstLast_name>Larisa Zoranić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2014-06</proposal_call><code>DOK-2014-06-9740</code><acronim><![CDATA[MS-FORMDES]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, </scie_field_hr><scie_field_en>Physics, </scie_field_en><institution_hr><![CDATA[Sveučilište u Splitu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Split, Faculty of Science]]></institution_en><team_members_id>5569</team_members_id><team_members_names><![CDATA[ Doktorand: Martina Požar ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[associated liquids, micro-heterogeneity, molecular dynamics, integral equation theory, antimicrobial peptides]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[The physics of associated liquids, amphiphilic solutions and lipids in water is determined by competing hydrophobic and hydrophilic interactions between various molecular groups. By exploring assemblies ranging from molecular to cellular sizes we are aiming at  building a unified view of the principal mechanisms responsible for domain formation and destruction. This new approach hasn&#39;t been explored as such in similar research projects. In the project&#39;s first year, by molecular dynamic simulations, we will quantify micro-heterogeneity in liquids as a structural order that exists on the local scale and doesn&#39;t propagate on the global scale. As a continuation of the first-year results, we will study how the structure of the above mentioned liquids changes when dissolving molecules that promote or destroy domains defined by the local ordering. The used methods will be simulations and integral equation theory. In parallel with the molecular scale studies, the cellular membranes will be probed by means of experimental measurements and simulations. The aim will be to describe the mechanism of destruction of lipid bilayers induced by antimicrobial peptides. Principal investigator Larisa Zoranić has competencies to establish a new research group with an interdisciplinary subject and members of diverse fields because of her scientific background in physics, biology and biophysics. She has experience working in both international and Croatian groups, thus obtaining the required managing skills. The group&#39;s acquired knowledge and expertize will ensure a good quality start towards more demanding issues that stem from the project. The aims and methods of this research are competitive internationally in the area of molecular physics and biophysics. This kind of innovative project, built around an interdisciplinary group and having strong connections with the diploma and doctorate studies, will strengthen the Croatian scientific network.]]></summary_en></project><project>
<id>2557</id><title_hr><![CDATA[Prospektivno biopsihosocijalno istraživanje utjecaja seksualno eksplicitnih materijala na socijalizaciju i zdravlje mladih]]></title_hr><title_en><![CDATA[]]></title_en><user_id>5817</user_id><user_firstLast_name>Aleksandar Štulhofer</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2014-06</proposal_call><code>DOK-2014-06-5015</code><acronim><![CDATA[PROBIOPS SEM STUDY]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Sociologija, </scie_field_hr><scie_field_en>Sociology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Filozofski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Humanities and Social Sciences]]></institution_en><team_members_id>17799</team_members_id><team_members_names><![CDATA[ Doktorand: Goran Koletić ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[Prospective study, panel, young people, reproductive and sexual health, emotional intimacy, committed relationships, sexually explicit material]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Digital technology has enabled an unprecedented availability and unrestricted use of sexually explicit material (SEM). As the first experiences with SEM almost invariably precede first sexual experiences, concerns have been raised about its potential impact on young people’s sexual socialization, subsequent reproductive and sexual health outcomes, as well as motivation and capacity for building and maintaining relationship intimacy. The field of socio-behavioural research on SEM has been marred by inability to distinguish between associations and causal links. The only available European panel study followed Dutch youth for only 12 months. To enable a more robust assessment of the links between SEM use and sexual socialization, health, and intimacy we propose to set up a 3-year panel sample with over 1,000 high-school students. The panel would be used to carry out biological testing on males (testosterone levels from saliva) and repeated online surveying in which the genre and the frequency of SEM use would be analyzed as predictors of subsequent sexual activity (particularly, sexual risk taking), the dynamics of attitudes toward women and committed relationships. We propose to test a conceptual model in which possible SEM influences on the outcomes are influenced by T levels, personality traits, family environment, characteristics of ego-centered social network, type of SEM used, and sexual experiences. Our biopsychosocial model aims to assess the contribution of SEM use to the process of young people’s sexual socialization, while controlling for the effects of biological makeup, intrapersonal characteristics, and interpersonal and group (family, peer group, partners) social influences.The proposed project is innovative in design and analytical conceptualization. The expected outcomes should be relevant not only in scientific terms but also in the context of public policy, particularly in the area of educational and public health interventions.]]></summary_en></project><project>
<id>2558</id><title_hr><![CDATA[Otkrivanje novih genetskih lokusa uključenih u regulaciju funkcije štitne i doštitne žlijezde]]></title_hr><title_en><![CDATA[]]></title_en><user_id>118</user_id><user_firstLast_name>Tatijana Zemunik</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2014-06</proposal_call><code>DOK-2014-06-8198</code><acronim><![CDATA[THYPARATHYFUNCTION]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Splitu, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Split School of Medicine]]></institution_en><team_members_id>17479</team_members_id><team_members_names><![CDATA[ Doktorand: Antonela Boljat ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[thyroid function, parathyroid function, genetic variants, polymorphisms, genome-wide study, gene-environmental interaction, complex phenotypes]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Thyroid diseases affect up to 10% of the general population creating an important public health problem. Parathyroid diseases are less frequent but not insignificant. Thyroid hormones act on every tissue regulating cellular development, differentiation and metabolism. Parathyroid hormones control the amount of calcium in the blood. The expression of thyroid and parathyroid hormones/antibodies is under polygenic control and influenced by environmental factors. The aim of this study is to identify genetic loci that are associated with levels of thyroid/parathyroid hormones and antibodies that will advance our understanding of the genetic basis of their function and thus provide additional knowledge relevant to clinical outcomes.  We will perform genome-wide association analysis of thyroid and parathyroid hormones/antibodies on 1,000 individuals from Split region (participants from the 10,001 Dalmatians project). The thyroid and parathyroid hormones/antibodies that are planned to be analysed are: free triiodothyronine, free thyroxine, thyroid-stimulating hormone, thyroglobulin, thyroid microsomal antibody titer, thyroglobulin antibody titer and parathiroid hormone. In addition, detailed anamnestic data and phenotype measurements already taken from study participants will be used in realization of second and third project objectives: investigation of relevant gene-environment interactions and determination of phenotype-phenotype correlation. We plan to follow-up interesting findings in additional 2,000 individuals and in datasets sought through international collaboration.Outcomes of such comprehensive approach will be generation of a new knowledge of genetic background, gene-environment interaction and phenotype-phenotype correlation associated with thyroid and parathyroid function that will lead to better understanding of biological pathways and clinically relevant disorders related to their function. The obtained results will promote excellence of Croatian research.]]></summary_en></project><project>
<id>2559</id><title_hr><![CDATA[Tvar i međudjelovanja na ubrzivačima  i u svemiru]]></title_hr><title_en><![CDATA[]]></title_en><user_id>335</user_id><user_firstLast_name>Krešimir Kumerički</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2014-06</proposal_call><code>DOK-2014-06-6473</code><acronim><![CDATA[MIAU]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, </scie_field_hr><scie_field_en>Physics, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>17794</team_members_id><team_members_names><![CDATA[ Doktorand: Petar Čuljak ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[quantum chromodynamics, hadrons, quarks and gluons, quark matter, leptons, neutrino mass, new particles at LHC, dark matter]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[     Hadrons, such as proton or pion, are particles composed ofquarks and gluons which interact through fundamental strongforce. Objective of MIAU project is to contribute to ourunderstanding of this strong force as described by thetheory of quantum chromodynamics (QCD). Additionally, we aimto study physical processes happening at hadronaccelerators, including electroweak production ofas-yet-unseen particles at the large hadron collider (LHC).Thereby, we will investigate models of new physics in whichsuch new particles are introduced in attempts to explainneutrino masses and abundance of dark matter in theuniverse.     To achieve these objectives we will study specific hadronicprocesses, both in the high-energy regime where strong forceis weak enough for perturbative approach, as well as inregimes where non-perturbative features of QCD, such asconfinement and chiral symmetry breaking come to the fore.Our focus will be on processes measured by the range ofexperimental collaborations which will facilitate closecontact with reality and immediate testing of our resultsand ideas.     As outcome, we expect to be able to significantly improvethe knowledge of the quark-gluon structure of the proton, asencoded by the so-called generalized parton distributions,to improve the description of various meson properties invacuum and at finite densities and temperatures, toelucidate QCD phase diagram in model frameworks, and to setbounds to the parameter space of several models of newphysics.]]></summary_en></project><project>
<id>2560</id><title_hr><![CDATA[FP7 projekt EMBRACE , br.: 282672 ]]></title_hr><title_en><![CDATA[]]></title_en><user_id>5979</user_id><user_firstLast_name>Darko Koracin</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2014-06</proposal_call><code>DOK-2014-06-4724</code><acronim><![CDATA[]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Geofizika, </scie_field_hr><scie_field_en>Geophysics, </scie_field_en><institution_hr><![CDATA[Sveučilište u Splitu]]></institution_hr><institution_en><![CDATA[University of Split]]></institution_en><team_members_id>17848</team_members_id><team_members_names><![CDATA[ Doktorand: Slavko Radilović ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>2563</id><title_hr><![CDATA[Dijagnostika autizma s robotskim evaluatorom]]></title_hr><title_en><![CDATA[]]></title_en><user_id>5054</user_id><user_firstLast_name>Zdenko Kovačić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2014-06</proposal_call><code>DOK-2014-06-9417</code><acronim><![CDATA[ADORE]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Elektrotehnika, </scie_field_hr><scie_field_en>Electrical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id>5058</team_members_id><team_members_names><![CDATA[ Doktorand: Frano Petric ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[social robotics, humanoid robots, autism, small children, diagnostics, rehabilitation]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Autism spectrum disorder (ASD) is a developmental disorder characterized by impairment in social interaction, verbal and nonverbal communication and by repetitive behaviors and interests. The diagnosis, which is usually given during the preschool period, depends on the education and experience of human evaluators, which can be susceptible to personal bias. The ongoing collaboration between the researchers from the Faculty of Electrical Engineering and Computing (FER) and Faculty of Education and Rehabilitation Sciences (ERF) initiated the use of humanoid robots in the process of ASD diagnostic procedures in preschool children. The goal of the project is the development of a robot-based diagnostic protocol and testing of its verification in clinical settings. The robots will be used as ASD co-evaluators to help a human evaluator to assess the child behavior objectively. To the best of our knowledge, such a robot-based ASD diagnostics system will be the first of its kind. Technically, this means developing specific robot skills and behaviors to be deployed within the standard clinical diagnostic procedure of ASD. The robots will have two functions: observation and quantitative measurement of child’s social responses; and performance of standardized social presses designed to provoke child response. This involves actions such as analyses of the audio signal and differentiation of vocalizations and speech, detection of eye-gaze direction, performance of different actions and gestures and utilization of human-robot and robot-robot interaction to attract child attention. Our interdisciplinary approach includes ERF&#39;s development of diagnostic protocol and its testing on children with and without ASD and FER&#39;s realization of needed robot behaviors using methods and algorithms from social signal processing, computer vision, machine learning and cognitive reasoning. This involves work on cooperation, cognition and human-robot interaction, focusing on multimodal communication.]]></summary_en></project><project>
<id>2564</id><title_hr><![CDATA[Molekularni mehanizmi imunološkog djelovanja PVR(CD155) u virusnoj i tumorskoj patogenezi]]></title_hr><title_en><![CDATA[]]></title_en><user_id>4941</user_id><user_firstLast_name>Tihana Lenac Roviš</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2014-06</proposal_call><code>DOK-2014-06-9006</code><acronim><![CDATA[PVRreg]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Medicine]]></institution_en><team_members_id>5204</team_members_id><team_members_names><![CDATA[ Doktorand: Paola Kučan ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[poliovirus receptor, PVR, CD155, cytomegalovirus, CMV, immunoevasion, tumor]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[The project is focused on the role of PVR (poliovirus receptor) which serves as a ligand for both inhibitory (TIGIT) and activating (DNAM-1 and Tactile) receptors. The evidence has been accumulated indicating the role of PVR and its receptors in immune surveillance including the control of viral infections, tumors, as well as in pathogenesis of autoimmune diseases. Of note is that PVR is constitutively expressed on the majority of somatic cells, while its receptors are expressed on the majority of lymphocyte population. In many respects the interaction of PVR with its paired set of inhibitory and activating receptors resemble the interaction of paired co-stimulatory immune cell receptors and their cellular ligands (B7/CD28/CTLA-4). These co-stimulatory molecules have been the subject of intensive studies that resulted in immunoregulatory pharmaceutical agents for use in humans. The studies proposed here are based on the finding that human cytomegalovirus (HCMV) affects the surface expression of PVR (Nat Immunol. 2005) and on our preliminary results indicating that mouse cytomegalovirus (MCMV) also downregulates mouse PVR. Thus, we first focused on the identification of MCMV gene(s) (proteins) involved in the PVR regulation, but also on the consequence of this viral regulation on antiviral immune response in vivo. To that aim we will generate MCMV mutants lacking viral regulators and test their in vivo susceptibility to components of innate and acquired immune response. We expect that the results obtained will further broaden the knowledge of PVR regulation and its significance in immune control, which will eventually help to translate this knowledge to developing new immunotherapeutic tools. Namely, one aim of this project is to engineer antibody specific for human PVR in order to be used as a tool in targeted tumor therapy. This idea is based on the fact that many tumors over-express PVR, which could be used in antibody mediated uptake of anti-tumor compounds. ]]></summary_en></project><project>
<id>2565</id><title_hr><![CDATA[Cjelogenomska analiza povezanosti Hashimotovog tiroiditisa]]></title_hr><title_en><![CDATA[]]></title_en><user_id>63</user_id><user_firstLast_name>Vesna Boraska</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2014-06</proposal_call><code>DOK-2014-06-6867</code><acronim><![CDATA[HashimotoGWAS]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Splitu, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Split School of Medicine]]></institution_en><team_members_id>17744</team_members_id><team_members_names><![CDATA[ Doktorand: Luka Brčić ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[Hashimoto thyroiditis, thyroid gland, genome-wide association analysis (GWAS), statistical genetics, single nucleotide polymorphism (SNP), biobank]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Autoimmune thyroid diseases (AITD) are very common and affect 2-5% of the general population. The most frequent form of AITD is Hashimoto thyroiditis (HT) that is characterised by progressive destruction of thyroid tissue. Many studies tried to unravel genetic contribution to HT development in the past few decades but with low success. The breakthrough of the genome-wide association studies (GWAS) tremendously increased the rate of detecting novel associations. However, HT has been unrepresented in the GWAS mostly because of the lack of large cohorts of HT patients and the performance of such study is a matter of urgency. We plan to recruit 500 HT patients and to create a DNA/serum/plasma biobank of deeply phenotyped HT patients that will serve as a powerful resource for current and future investigations. The aim of this study is to identify genetic variants underlying HT by performing the first GWAS focusing on HT exclusively. We will use newly recruited HT patients and 500 existing controls (from the “10,000 Dalmatians” study) in case-control GWAS and validate observed associations in an independent replication cohort. To further help in elucidating genetic contribution to HT we will perform pathway analysis and gene-interaction analysis using variety of environmental factors and medical records that will be collected from HT patients. We will also perform deep phenotype characterisation of HT patients that may provide additional clues about HT aetiology. This is timely planned study that aims to generate new knowledge that will advance our understanding of the genetic basis and underlying biological mechanisms of HT. This knowledge will be crucial in guiding the development of new prevention, diagnostic and therapeutic methods. Other benefits of this project include promotion of collaboration, transfer of knowledge, building of infrastructure and it will help in establishment of independent research carrier of principal investigator.]]></summary_en></project><project>
<id>2566</id><title_hr><![CDATA[Ekološki prihvatljiva zaštita metalnih konstrukcija izloženih agresivnom djelovanju mora]]></title_hr><title_en><![CDATA[]]></title_en><user_id>5203</user_id><user_firstLast_name>Helena Otmačić Ćurković</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2014-06</proposal_call><code>DOK-2014-06-9683</code><acronim><![CDATA[]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Kemijsko inženjerstvo, </scie_field_hr><scie_field_en>Chemical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet kemijskog inženjerstva i tehnologije]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Chemical Engineering and Technology]]></institution_en><team_members_id>17745</team_members_id><team_members_names><![CDATA[ Doktorand: Ekatarina Kristan ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>2567</id><title_hr><![CDATA[Klima jadranske regije u njenom globalnom kontekstu]]></title_hr><title_en><![CDATA[]]></title_en><user_id>3375</user_id><user_firstLast_name>Mirko Orlić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2014-06</proposal_call><code>DOK-2014-06-3666</code><acronim><![CDATA[CARE]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Geofizika, </scie_field_hr><scie_field_en>Geophysics, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>17753</team_members_id><team_members_names><![CDATA[ Doktorand: Maja Bubalo ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[Adriatic, climate change, extremes, climate models, downscaling, spatial interpolation, sea-level trend, coastal flooding, sea-level projections]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Temporal and spatial statistical analysis of climatological variables will be performed, with the emphasis on the multidecadal changes in temperature and precipitation indices of extremes in the Adriatic region. Particular attention will be paid to the analysis of drought, floods and heat waves. Possible change in climate suitability for tourism will be investigated. The obtained gridded fields will become a reference data for the validation of climate models and an input into the flash-flood warning systems. Current and future climate of the Mediterranean area will be examined by analyzing the results of global-model simulations and by using the statistical and dynamical downscaling approach. Simulations by RegCM4.2 regional climate model will be performed at the horizontal resolution of 12.5 km. Also planned is to utilize results from experiments based on coupled atmosphere-ocean models from the currently running Med-CORDEX project with a purpose of analyzing the contribution of oceanic component in the simulations over the Adriatic Sea and the surrounding land area. Trends and interdecadal variability of sea level in the Mediterranean sub-basins will be identified and contributions of the governing processes will be assessed. Coastal flooding in the Northern Adriatic and time evolution in occurrence of extreme sea levels in the context of mean-sea-level rise will be considered. Finally, older variants of semi-empirical method of projecting global sea level will be compared with the more general method recently developed. It is expected that the project thus considered will meet the three important criteria (relevance, reliability, feasibility), by addressing one of the few priorities put forward by the European Union in its growth strategy Europe 2020, by relying on the state-of-the-art methods of data analysis and modeling, and by involving a majority of researchers engaged in the study of climate-related physical processes in Croatia.]]></summary_en></project><project>
<id>2568</id><title_hr><![CDATA[Uokvireno ziđe - kompozitni nosivi sustav kod armirano-betonskih zgrada]]></title_hr><title_en><![CDATA[]]></title_en><user_id>131</user_id><user_firstLast_name>Vladimir Sigmund</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2014-06</proposal_call><code>DOK-2014-06-8930</code><acronim><![CDATA[FRAmed-MAsonry]]></acronim><duration></duration><status>Prekinut</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Građevinarstvo, </scie_field_hr><scie_field_en>Civil engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište Josipa Jurja Strossmayera u Osijeku, Građevinski i arhitektonski fakultet Osijek]]></institution_hr><institution_en><![CDATA[Josip Juraj Strossmayer University of Osijek, Faculty of Civil Engineering and Architecture Osijek]]></institution_en><team_members_id>17741</team_members_id><team_members_names><![CDATA[ Doktorand: Ervin Kožoman ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[r/c frames, masonry infill, behavior, safety, modelling, standardization, framed-masonry]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[In r-c frames infilled with masonry (framed-masonry) the infill walls stiffen the frame and reduce the first-mode period leading to a reduction in drift response to strong ground motion. At the same time, the addition of the masonry wall to the frame tends to increase the base-shear response and reduce the drift capacity of the structure. The increase of lateral force and reduction of drift capacity leads to serious vulnerabilities unless proper proportioning is exercised. For frames with competent walls, the challenge for safe and economical design is to be able to take advantage of the stiffening but to make certain that the increase in lateral forces and reduction in drift capacity do not handicap performance. Available evidence has pointed out that shear strength of the confining column is the &#39;&#39;Achiless&#39;s heel&#39;&#39; of the system. Solution of the problem requires understanding the behavior of masonry and concrete subjected to dynamic and random loading reversals, a challenge that demands testing under reasonably realistic conditions for confident analysis of the problem and its generalization.This is a proposal to investigate the safety and behavior of buildings with masonry-infilled r-c frames through near full-scale dynamic earthquake-simulation tests accompanied by supporting pseudo-dynamic tests of structural assemblies and components and by calibrated analytical solutions. The overall goal is to develop pragmatic methods, by cooperative efforts of team members and co-working international body, for design, safety evaluation and standardization. Because framed-masonry serve both architectural and structural demands efficiently, people in seismic regions live and will continue to live in buildings of this type. An organized solution of the safety of such construction is essential. This proposal intends to put the &#39;&#39;framed-masonry&#39;&#39; composite up as a full-fledged building type, it is &#39;&#39;transformative&#39;&#39; and will change design practice.]]></summary_en></project><project>
<id>2569</id><title_hr><![CDATA[Povezanost fleksibilnosti, aktivnosti i strukture u porodici dipeptidil-peptidaza III]]></title_hr><title_en><![CDATA[]]></title_en><user_id>2974</user_id><user_firstLast_name>Sanja Tomić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2014-06</proposal_call><code>DOK-2014-06-6802</code><acronim><![CDATA[FlAcS]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, </scie_field_hr><scie_field_en>Chemistry, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>17832</team_members_id><team_members_names><![CDATA[ Doktorand: Marko Tomin ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[dipeptidyl peptidase III, metallopeptidase, catalytic activity, protein flexibility, MD simulations, QM/MM, H/D exchange, protein interactions]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Within the project frame we intend to investigate diversity in evolutionary conserved metallopeptidase family M49 (DPP III family) through characterization of catalytic, structural and dynamical properties of its members. The project would encompass five dipeptidyl peptidases III (DPP III): human, yeast, two bacterial orthologs, from thermophile Caldithrix abyssi and oral pathogen Porphyromonas gingivalis, and a DPP III from plant Physcomitrella patens. The DPP III cleaves dipeptides from the N-terminus of many oligopeptides and contributes to the intracellular protein metabolism as well as to endogenous defense against oxidative stress. Human DPP III (h.DPP III) is also related to pathological processes of cataractogenesis, tumor growth and influenza virus infection. The project research should elucidate whether the large flexibility determined for h.DPP III is conserved within DPP IIIs, and how it correlates with the protein function. It would reveal submolecular details important for substrate stabilization and, in the case of h.DPP III, the enzymatic mechanism. Elucidation of the key interactions between h.DPP III and Keap1 protein (Nrf2-Keap1 signalling pathway is major regulator of cytoprotective responses to oxidative and electrophilic stress), and possible correlation of DPP III flexibility with the complex stability, should aid in clarification of its cellular roles. Plant DPP III, differently from DPP IIIs in other organisms possesses a NUDIX box. The project should elucidate its potential dual activity (peptidase and NUDIX). Study of DPP III from thermophile should improve our knowledge on thermophile proteins, potentially useful in biotechnology. In order to fulfill the outlined goals a finely tuned multidisciplinary approach would be used in which molecular biology, biochemistry and mass spectrometry methods would be complemented with bioinformatics, multiscale molecular modeling (coarse grained/all atom MD, QM/MM) and macromolecular crystallography.]]></summary_en></project><project>
<id>2570</id><title_hr><![CDATA[Razvoj fotokatalitičkih polimernih nanokompozita za obradu otpadnih voda]]></title_hr><title_en><![CDATA[]]></title_en><user_id>913</user_id><user_firstLast_name>Zlata Hrnjak-Murgić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2014-06</proposal_call><code>DOK-2014-06-1233</code><acronim><![CDATA[DePoNPhoto]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Kemijsko inženjerstvo, </scie_field_hr><scie_field_en>Chemical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet kemijskog inženjerstva i tehnologije]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Chemical Engineering and Technology]]></institution_en><team_members_id>17771</team_members_id><team_members_names><![CDATA[ Doktorand: Vanja Gilja ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[conducting polymers,  metal oxide nanoparticles, polymer nanocomposites, structure-properties relations, wastewater treatment]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Environmental problems associated with water pollution are an important issue correlated negatively with the health and ecosystem. The main goal of this proposal is to develop novel polymer nanocomposites of extending photoactivity toward visible region under UV/VIS light irradiation and to introduce an innovative technology for water purification. The conducting polymers (CPs) are known as good hole conducting materials1 and are combined with semiconductor nanoparticles to produce a synergistic effect and complementary properties. Due to that Polyaniline (PANI), polypyrrole (PPy) and poly(3,4-ethylene-dioxythiophene) (PEDOT) conducting polymers will be studied with metal oxides (TiO2, ZnO) nanoparticles to develop polymer nanocomposite photocatalysts (CPNPs) with enhanced photocatalytic properties. The optimal structure-properties relationships are crucial for efficient degradation of organic contaminants in water to convert them into harmless chemicals. Novel CPNPs will be applied in photocatalytic degradation of organic azo dyes (reactive red 45 and methyl orange) chosen as targeted wastewater pollutants. The utilization of waste material, fly ash, as a catalyst support will be explored to provide the additional environmental benefit. The proposed integral approach that will be used in the evaluation of the process efficiency will scrutinize any negative implications of CPNPs application. The project will contribute to the development and modernization of science and technology in Croatia, advancing toward the knowledge-based society within the European research area.Project includes a multidisciplinary effort, ranging from polymer science and technology, chemistry and environmental chemistry to electrochemical engineering, in order to meet challenging project tasks and propose an efficient photocatalytic polymer nanocomposite for sustainable water treatment technology. 1. M.R. Karim, C.J. Lee, Y.T. Park, M.S. Lee, J. Polym. Chem. 14 (2006) 5283–5290.]]></summary_en></project><project>
<id>2571</id><title_hr><![CDATA[eWALL]]></title_hr><title_en><![CDATA[]]></title_en><user_id>5854</user_id><user_firstLast_name>Dina Šimunić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2014-06</proposal_call><code>DOK-2014-06-6634</code><acronim><![CDATA[]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Elektrotehnika, </scie_field_hr><scie_field_en>Electrical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id>19130</team_members_id><team_members_names><![CDATA[ Doktorand: Antonija Marinčić ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>2572</id><title_hr><![CDATA[Multi-level actions for enhanced Heating & Cooling plans (STRATEGO)]]></title_hr><title_en><![CDATA[]]></title_en><user_id>2536</user_id><user_firstLast_name>Daniel Rolph Schneider</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2014-06</proposal_call><code>DOK-2014-06-6302</code><acronim><![CDATA[]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Strojarstvo, </scie_field_hr><scie_field_en>Mechnical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet strojarstva i brodogradnje]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Mechanical Engineering and Naval Architecture]]></institution_en><team_members_id>17796</team_members_id><team_members_names><![CDATA[ Doktorand: Tihomir Tomić ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>2573</id><title_hr><![CDATA[Tekstilne antene za pametno okruženje]]></title_hr><title_en><![CDATA[]]></title_en><user_id>6555</user_id><user_firstLast_name>Davor Bonefačić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2014-06</proposal_call><code>DOK-2014-06-6996</code><acronim><![CDATA[TexASE]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Elektrotehnika, </scie_field_hr><scie_field_en>Electrical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id>17757</team_members_id><team_members_names><![CDATA[ Doktorand: Andrej Galoić ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[antenna, textile antenna, wearable antenna, on-body communications, body-centric communications]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[The smart environment consists of wired and wireless network of communication devices and sensors which communicate between themselves and with humans, and enable safer, more pleasant and energy efficient environment adaptable to the change of conditions and tasks. Any wireless device needs an antenna as the interface between the electronic circuits and the free space. Wireless communication modules, sensors and RFID devices are integrated in common objects like clothes, home appliances, toys, consumables, etc. The used antennas must be small and unobtrusive, yet energy efficient. The aim of this project is to investigate new materials and techniques for antenna fabrication including conductive textiles and threads. A textile antenna integrated into clothes must be lightweight, flexible, and comfortable to wear, but still must keep good radiation properties. Textile antennas are very interesting for military personnel on the field as well as for rescue teams. Another important application is healthcare, where wireless sensors in real time monitor the patients&#39; health status and transmit data to the medical personnel. The broadest field of application of wearable antennas is in the entertainment and consumer electronics and mobile communications. Energy harvesting, and with it the associated antennas, can be used in all these fields to increase energy efficiency and enable operation of mobile devices. The aim of this project is to propose new and adapt existing antenna designs for integration into clothing and for new manufacturing techniques like embroidering or weaving. Another aspect to be considered in connection with wearable antennas is their operation in the proximity of human body which is a lossy dielectric. The second aim of this project is to study both theoretically and experimentally the propagation channel on the surface of the human body and off-body communications. The results will allow designing reliable on-body and off-body communication systems. ]]></summary_en></project><project>
<id>2575</id><title_hr><![CDATA[Fizika Standardnog modela i njena proširenja]]></title_hr><title_en><![CDATA[]]></title_en><user_id>4709</user_id><user_firstLast_name>Fabrizio Nesti</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2014-06</proposal_call><code>DOK-2014-06-3949</code><acronim><![CDATA[PhySMaB]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, </scie_field_hr><scie_field_en>Physics, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>17814</team_members_id><team_members_names><![CDATA[ Doktorand: Goran Popara ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[theoretical particle physics,  Standard Model, perturbative calculations, physics beyond Standard Model, neutrinos]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[In high energy particle physics it is widely believed that the energy frontier experiments at LHC and the planned linear colliders, ILC and/or CLIC, together with ongoing and new experiments in neutrino and flavour physics will unravel fundamental problems in particle and astroparticle physics. A prerequisite for this progress is the complete understanding of the Standard model (SM) predictions. One of the triumphs of SM physics has been the extent to which QCD successfully describes strong interaction processes observed at colliders. More accurate QCD calculations are nowadays essential in understanding the enormous amount of available high-precision data, particularly since new physics effects are obscured by standard QCD processes. Our focus in that area will be to improve the description of hard exclusive processes by including higher-order contributions and by further developing the corresponding methods for automatic QCD calculations. Furthermore, we plan to do precision studies of top-quark production and decay observables which provide a unique view to the mechanism of electroweak symmetry breaking, important for understanding of particle mass generation. In the top-quark decay the information about its spin polarization imprinted by the production process is preserved, and can be calculated and measured in angular distributions of decay products providing other way to search for deviations from the SM expectations. Regarding new physics, the fact that neutrinos have a mass already requires an extension of the SM and calls for an understanding of the origin of neutrino masses. The seesaw mechanism, included in a theory as the one where left-right symmetry (parity) is restored at accessible LHC energies, stands out as a prominent theoretical candidate, and this theory links the origin of neutrino masses to new interactions at high energies and to the restoration of parity. A phenomenological investigation of these predictions is thus compelling and timely.]]></summary_en></project><project>
<id>2576</id><title_hr><![CDATA[„Metal-Hydride Organic Frameworks (HOF)-new solids for gas adsorption and separation”- SCOPES projekt]]></title_hr><title_en><![CDATA[]]></title_en><user_id>11146</user_id><user_firstLast_name>Jasminka Popovic</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2014-06</proposal_call><code>DOK-2014-06-9951</code><acronim><![CDATA[]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, </scie_field_hr><scie_field_en>Chemistry, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>17733</team_members_id><team_members_names><![CDATA[ Doktorand: Sanja Brkić ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>2577</id><title_hr><![CDATA[Detekcija objekata više razreda za pametna vozila i sigurnije ceste]]></title_hr><title_en><![CDATA[]]></title_en><user_id>361</user_id><user_firstLast_name>Siniša Šegvić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2014-06</proposal_call><code>DOK-2014-06-4744</code><acronim><![CDATA[MULTICLOD]]></acronim><duration></duration><status>Prekinut</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Računarstvo, </scie_field_hr><scie_field_en>Computer sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id>6565</team_members_id><team_members_names><![CDATA[ Doktorand: Ivan Krešo ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[Computer vision, structure from motion, object detection, image categorization, multi-body structure from motion]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Throughout the last decades we witness persistent improvement in understanding ways to make machines see. Consequently, opportunities for computer vision applications are becoming more and more abundant. Understanding dynamic traffic scenes is especially interesting due to exciting applications in the fields of smart vehicles (driver assistance, autonomous cars) and intelligent transportation systems (road safety inspection, adaptive traffic control). Nevertheless, many of these applications are out of reach since the computers are still unable to match human perception. We believe that this gap would be reduced by improving our understanding of scalable detection of multiple object classes in dynamic scenes.The task of object detection is to localize objects of interest in input images. We address detection in the most general case where the objects of interest exhibit large appearance variation. In this case the problem is often referred to as multi-class object detection. Our proposal focuses on dynamic traffic scenes acquired by a calibrated stereo rig from the driver&#39;s perspective. We propose to develop detection approaches which would combine estimated camera motion and scene structure with learned appearance features, and to experimentally compare them with the state of the art. We shall employ advanced methodologies such as SfM, dense stereo, variational optimization, scene flow, spatio-temporal descriptors, latent SVM and Fisher vectors. These methodologies shall enable us to achieve improvements upon the state of the art in terms of scalability and detection performance. This will open way to exciting applications capable of reducing traffic accidents, improving efficiency and decreasing traffic congestion. Some of these applications shall be demonstrated by experiments on a real autonomous car. The proposed research would also contribute to a future unified theory of computer vision which would encompass detection, reconstruction and categorization.]]></summary_en></project><project>
<id>2580</id><title_hr><![CDATA[GENOMIKA I MOLEKULARNA EPIDEMIOLOGIJA HUMANIH PARAMIKSOVIRUSA U HRVATSKOJ]]></title_hr><title_en><![CDATA[]]></title_en><user_id>936</user_id><user_firstLast_name>DUBRAVKO FORČIĆ</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2014-06</proposal_call><code>DOK-2014-06-3771</code><acronim><![CDATA[ParamyxoCro]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu]]></institution_hr><institution_en><![CDATA[University of Zagreb]]></institution_en><team_members_id>17817</team_members_id><team_members_names><![CDATA[ Doktorand: Anamarija Slović ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[Paramyxoviruses, molecular evolution, genomics, virus genotype, molecular epidemiology]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[The family Paramyxoviridae harbors a broad spectrum of serious virus pathogens that are of importance to human health and global economics. Paramyxoviruses are RNA viruses with a single-stranded negative sense genome. They have been isolated from a wide variety of species, demonstrating a vast host range and great viral genetic diversity. These ubiquitous pathogens are among the most common causatives of respiratory tract infections and are responsible for a high degree of morbidity and mortality worldwide. The biology of RNA viruses is influenced by their high potential of continuous evolution. Because of the error-prone nature of their RNA-dependent RNA polymerases and large population sizes, RNA viruses show high levels of genetic diversity. Mutations can significantly influence virus biological properties and lead to appearance of new strains. The knowledge of viral evolution depends on the amount of genomic data available for analysis.We propose the research of viral genomics of wild type paramyxoviruses currently circulating in Croatia. It is our goal to increase the number of genetically well characterized paramyxoviral wild-type strains. The proposed work will add to knowledge about paramyxoviral ecology, variability and evolutionary capacities. As molecular epidemiologic monitoring of circulating wild type viruses enables analysis of current relations between existing viral genotypes, it is an invaluable part of virus surveillance and control, facilitating the detection of endemic areas, estimations of vaccine efficacies and predications of possible outbreaks.]]></summary_en></project><project>
<id>2581</id><title_hr><![CDATA[Istraživanje uloge optineurina u neuroprotekciji]]></title_hr><title_en><![CDATA[]]></title_en><user_id>4630</user_id><user_firstLast_name>Ivana Munitić </user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2014-06</proposal_call><code>DOK-2014-06-4658</code><acronim><![CDATA[OptineurinNeuroimm]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Biotehnologija, </scie_field_hr><scie_field_en>Biotechnology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Fakultet biotehnologije i razvoja lijekova]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Biotechnology and Drug Development]]></institution_en><team_members_id>12500</team_members_id><team_members_names><![CDATA[ Doktorand: Andrea Markovinović ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[cell signalling, autophagy, microglia, neurodegeneration, animal models]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Mutations in a widely expressed ubiquitin-binding protein optineurin were recently found in amyotrophic lateral sclerosis (ALS), a fatal neurodegenerative disease of unresolved pathogenesis. Unlike most of the other mutated proteins known to cause ALS by their toxic prion-like properties, optineurin is largely thought to cause disease by loss-of-function, arguing for its protective role. In vitro studies proposed that it regulates a variety of cellular processes including cell signaling, autophagy and vesicle trafficking, but their link to neurodegeneration is unknown. ALS is not an autonomous disease of selected neurons. Glial cells including microglia, are essential for neuroinflammation, which greatly shapes disease progression. The major aim of this study is to elucidate the exact role(s) whereby optineurin exerts neuroprotection, pinpoint the cell types in which it acts, and determine its putative effect(s) on the interactions between the cell types relevant for neurodegeneration. We aim to dissect these questions in a stepwise fashion by (1) assessing cell-intrinsic functions in neurons, microglia and macrophages, (2) addressing crosstalk in mix-and-match co-cultures and organotypic spinal cord slices, and (3) verifying these findings in mice. To this end, we have generated a novel disease-mimicking genetic mouse model of optineurin insufficiency. Analyzing the function of optineurin in primary cells and mice models is crucial to the success of this study, given that ubiquitin-binding proteins are prone to in vitro artifacts. Incomplete understanding of ALS pathogenesis is directly mirrored in almost complete inability to treat ALS patients: a single approved drug exerts only a small prolongation in survival. Here, we propose to study a unique ALS model, set apart from the currently available models of direct toxicity by its ability to provide insight into basic neuroprotective mechanisms, thus expectedly paving the way for more successful therapies.]]></summary_en></project><project>
<id>2582</id><title_hr><![CDATA[Genetika i fiziologija tolerancije na višestruki stres kod kukuruza]]></title_hr><title_en><![CDATA[]]></title_en><user_id>3305</user_id><user_firstLast_name>Domagoj Šimić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2014-06</proposal_call><code>DOK-2014-06-6159</code><acronim><![CDATA[MUST-MAIZE]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Poljoprivreda, </scie_field_hr><scie_field_en>Agriculture, </scie_field_en><institution_hr><![CDATA[Poljoprivredni institut Osijek]]></institution_hr><institution_en><![CDATA[Agricultural Institute Osijek]]></institution_en><team_members_id>17788</team_members_id><team_members_names><![CDATA[ Doktorand: Vlatko Galić ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[drought, diabrotica, plant density, cadmium excess, genomic selection]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Plant responses to different stresses are highly complex and involve changes at the genetic and physiological levels. Maize as a major crop worldwide is essential for industry and is cultivated mostly in rain-fed cropping systems where changes in climate or diminishing water supply take place. Grain yield, the most important trait in maize as a composite trait is influenced by many stress-related traits. The main goal of this project is to elucidate and integrate common genetic and physiological mechanisms underlying the multiple-stress tolerance in maize. The specific aims are to detect genetic and physiological factors responsible for plant response to high plant density, drought, Diabrotica and Fusarium attacks as well as cadmium excess in soil in testcrosses of two maize populations (reference IBM population and a doubled haploid population) and their respective parents. By investigating root and leaf characteristics including chlorophyll fluorescence and other stress parameters as reliable indicators of stress in four-year field and pot experiments conducted in Croatia and Turkey, DNA marker-assisted selection and genomic selection could accelerate maize breeding for yield, abiotic and biotic stress tolerance. A multidisciplinary approach, which ties together breeding, physiology and molecular genetics, can bring a synergistic understanding to the response of maize to multiple stresses.]]></summary_en></project><project>
<id>2583</id><title_hr><![CDATA[Definiranje uloge cirkadijurnih gena kod bihevioralne senzitizacije na psihostimulanse kod Drosophile melanogaster]]></title_hr><title_en><![CDATA[]]></title_en><user_id>69</user_id><user_firstLast_name>Rozi Andretić Waldowski</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2014-06</proposal_call><code>DOK-2014-06-9244</code><acronim><![CDATA[FLYHIGH]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Biologija, </scie_field_hr><scie_field_en>Biology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci]]></institution_hr><institution_en><![CDATA[University of Rijeka]]></institution_en><team_members_id>4624</team_members_id><team_members_names><![CDATA[ Doktorand: Ana Filošević ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[addiction, psychostimulants, Drosophila, circadian, genes, screen]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Addiction to drugs is a brain disease characterized by changes in the brain functioning caused by repeated drug taking. Repeated drug taking leads to neuroadaptations which over time affect neural networks and change behavior. One such change induced by drugs and commonly studied in lab animals is behavioral sensitization. Regulation of gene expression is one important mechanism by which drugs change the plasticity of the networks which regulate behavior. A group of transcriptional regulators of the molecular circadian clock have been identified to function as regulators of behavioral sensitization to cocaine in Drosophila. Subsequent studies in rodents proved the universality of those genes in mediating drug responses. The genetic pathways and molecular interactions through which circadian genes regulate drug responses has remained undefined.We hypothesize that new genes which interact with circadian genes in the regulation of behavioral sensitization to psychostimulants can be identified in a genetic screen in Drosophila. This is a goal for which Drosophila is perfectly suited, because genetic screens aimed at defining new genes can be performed relatively easy, fast and cheap. Our first aim is to devise a high-throughput method for measuring behavioral sensitization in flies by modifying the existing method for measuring activity. Second, we will undertake a directed behavioral screen by pre-selecting candidates with reported molecular interaction with circadian genes. In the third aim we will use transgenic flies and other genetic tools to investigate neural mechanisms involved in behavioral sensitization. The proposed research is innovative and relevant for human health. New gene candidates isolated in this screen could easily be translated into mammalian research where they will help in further understanding of neuroplastic changes induced by psychostimulants. Given our expertise and available resources the project has great potential to advance the field.]]></summary_en></project><project>
<id>2584</id><title_hr><![CDATA[Repozitorij metafora hrvatskoga jezika]]></title_hr><title_en><![CDATA[]]></title_en><user_id>3388</user_id><user_firstLast_name>Kristina Štrkalj Despot</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2014-06</proposal_call><code>DOK-2014-06-6207</code><acronim><![CDATA[Meta4Cro]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Filologija, </scie_field_hr><scie_field_en>Philology, </scie_field_en><institution_hr><![CDATA[Institut za hrvatski jezik]]></institution_hr><institution_en><![CDATA[Institute of Croatian Language]]></institution_en><team_members_id>4835</team_members_id><team_members_names><![CDATA[ Doktorand: Ivan Pandžić ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[conceptual metaphor, image schemas, frames, metonymy, metaphor in natural language processing and artificial intelligence]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[The Croatian Metaphor Repository project will involve: theoretical research of conceptual metaphor, metonymy, image schemas and frames in the Croatian language from a synchronic and diachronic perspective; computational linguistic research on metaphor in natural language processing and artificial intelligence involving developing tools for semi-automatic metaphor detection and semi-automatic extraction of linguistic metaphors; psychological experiments to further explain the nature of the links between concept meaning and perception as manifested through primary metaphors. The applied goal of the project is to create a metaphorical language database ? the Croatian Metaphor Repository. The database will be available on the Internet. It will include the following levels: conceptual metaphors, linguistic metaphors, image schemas, cogs and frames. Metaphors will be divided by type (primary, complex and entailed metaphors), by level (general, specific), and by family (Event Structure Metaphors, Mind Metaphors, Morality Metaphors, Scalar Metaphors, Time Metaphors, Emotion Metaphors, Economics Metaphors, Governance Metaphors, Cascade Metaphors, Well-being Metaphors etc.). The theoretical background for the linguistic analysis of conceptual metaphors is the Neural Theory of Language and Thought and the Neural Theory of Metaphor. Formal annotation tools are taken from embodied construction grammar. Both theoretical research and the creation of the repository will significantly advance Croatian cognitive and computational linguistics, artificial intelligence studies and the research of language and learning processes. The database will allow for generalizations and will become a very useful tool for cross-linguistic and cross-cultural research of metaphor and thought leading to further development of the theory and the field and to understanding how people learn, understand, and use language. The project has significant potential for further international development.]]></summary_en></project><project>
<id>2586</id><title_hr><![CDATA[Upravljanje vodom i toplinom i trajnost membranskih gorivnih članaka]]></title_hr><title_en><![CDATA[]]></title_en><user_id>1118</user_id><user_firstLast_name>Frano Barbir</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2014-06</proposal_call><code>DOK-2014-06-4783</code><acronim><![CDATA[PEMFUELCELL]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Strojarstvo, </scie_field_hr><scie_field_en>Mechnical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Splitu, Fakultet elektrotehnike, strojarstva i brodogradnje]]></institution_hr><institution_en><![CDATA[University of Split, Faculty of Electrical Engineering, Mechanical Engineering and Naval Architecture]]></institution_en><team_members_id>17740</team_members_id><team_members_names><![CDATA[ Doktorand: Ivan Pivac ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[PEM fuel cell,  temperature control, humidity of reactant gases, durability stressors, decay mechanisms]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[The subject of the proposed research and development are the fuel cells – devices for direct electrochemical conversion of fuel (usually hydrogen) into electricity, with many potential applications, from propulsion of vehicles to mobile and stationary power generation at different scales (from mW to MW). This project will investigate a possibility to design and operate a Polymer Electrolyte Membrane (PEM) fuel cell with ambient air without external humidification using water and heat produced inside the fuel cell. This may be accomplished with adequate temperature distribution along the cathode channel, which would require a specific design of the fuel cell in terms of spatially variable heat transfer rates, and corresponding control of the cooling subsystem. In order to determine whether the proposed concept would result in longer life of fuel cell, some basic understanding of causes of fuel cell degradation is needed, particularly related to water and heat management. Particularly, it is proposed to investigate heat transfer in nano-structured catalyst layer because inadequate heat removal from the electrochemical reaction sites may be one of the causes for fuel cell degradation. Other stressors will be studied as well, and procedures for accelerated durability testing will be established, in order to confirm that the proposed concept of  water and heat management is beneficial to fuel cell durability.The proposed research is expected to improve understanding of water and heat transfer in PEM fuel cell, including the effects that dry conditions and inadequate heat removal from the catalyst sites may have on fuel cell durability. This novel concept of variable temperature along the cathode channel would result in simplification of the fuel cell support system by eliminating the devices needed for external humidification, without affecting fuel cell performance and durability in various applications.]]></summary_en></project><project>
<id>2587</id><title_hr><![CDATA[Sveobuhvatni model istraživanja zabrinutosti za privatnost u online okruženju]]></title_hr><title_en><![CDATA[]]></title_en><user_id>177</user_id><user_firstLast_name>Jelena Budak</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2014-06</proposal_call><code>DOK-2014-06-7067</code><acronim><![CDATA[PRICON]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Ekonomija, </scie_field_hr><scie_field_en>Economy, </scie_field_en><institution_hr><![CDATA[Ekonomski institut Zagreb]]></institution_hr><institution_en><![CDATA[Institute of Economics in Zagreb]]></institution_en><team_members_id>17736</team_members_id><team_members_names><![CDATA[ Doktorand: Vedran Recher ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[online privacy concern, antecedents, internet, consumer protection, survey]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[The research project will develop a comprehensive integrated model of privacy concern in the online environment and empirically test it in order to provide deeper understanding of various interactions between antecedents, concerns and consequences of online privacy. The research objectives will be achieved initially by identifying and developing (i) a comprehensive list of antecedents such as demographic factors (e.g. gender, education), experience factors (e.g. internet use experience, web expertise) and social-psychological factors (values, attitudes), and (ii) a comprehensive list of consequences of online privacy concern on individual-user level. These inputs will be used to develop an extended integrated model of online privacy concern in order to examine conceptual interrelations. Upon building a model, a customized survey questionnaire will be designed and measurement instruments for variables tested. The field research will consist of surveying 2,000 citizens in Croatia to assess their attitudes and behavior patterns when taking different roles and actions in the online environment. This core part of the research aims to empirically test the conceptualized model by employing adequate analytical tools to the large database collected in the survey. The research will result in the final definition of integrated theoretical framework of online privacy concern that will consolidate various streams of research in this field. The extended model of online privacy concern could be applied in future development in the related domain. The additional project outcomes are policy implications and recommendations for regulatory control, internet users policy and business strategies.]]></summary_en></project><project>
<id>2588</id><title_hr><![CDATA[Dizajn, sinteza i evaluacija novih protuotrova kod trovanja živčanim bojnim otrovima i pesticidima]]></title_hr><title_en><![CDATA[]]></title_en><user_id>872</user_id><user_firstLast_name>Zrinka Kovarik</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2014-06</proposal_call><code>DOK-2014-06-4854</code><acronim><![CDATA[CHOLINESTERASE]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, </scie_field_hr><scie_field_en>Chemistry, </scie_field_en><institution_hr><![CDATA[Institut za medicinska istraživanja i medicinu rada]]></institution_hr><institution_en><![CDATA[Institute for Medical Research and Occupational Health]]></institution_en><team_members_id>17747</team_members_id><team_members_names><![CDATA[ Doktorand: Tamara Zorbaz ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[acetylcholinesterase, butyrylcholinesterase, bioscavengers, prophylaxis, in silico drug-design, oximes, bronchodilatators]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Our main goal is to develop new compounds to serve as more efficient antidotes and improve the treatment of highly toxic organophosphorus (OP) compound poisoning. OP compounds used as pesticides account for over 3,000,000 registered accidental or deliberate cases of poisoning per year worldwide. Furthermore, OPs known as nerve agents (soman, sarin, tabun, VX) present a threat in terrorist attacks and conflicts, as was the case recently in Syria. The main targets of OP compounds are cholinesterases: acetylcholinesterase (AChE), the essential enzyme in neurotransmission, and butyrylcholinesterase (BChE), its back-up enzyme. However, the antidotes currently in use, which act as reactivators of inhibited AChE, were empirically synthesized before the two enzyme’s crystal structures were resolved. Due to structural requirements, their binding affinity and reactivation rate have not been well-balanced. This project utilizes new compounds to gain a better understanding of the mechanistic basis of the limitations of reactivation and find new effective leads for further in vivo study. We will combine several approaches, including: a study of the finely tuned interplay between these two sister enzymes, computational and experimental studies of cholinesterase interactions with a wide range of ligands defining favourable characteristic for potential new antidotes, in silico design of novel compounds that will direct the subsequent synthesis of selected leads, and thorough in vitro and in vivo experimental evaluation guided by strict cost-benefit criteria. Such a comprehensive approach will enable us to test a wide selection of candidates in a more reliable manner and obtain unambiguous data for further enhancements of the antidotal treatment. This will also enable us to explore other possible OP treatments such as highly-effective bioscavengers. Many of the findings that would arise from this project should have an impact that reaches far beyond the level of cholinesterases.]]></summary_en></project><project>
<id>2589</id><title_hr><![CDATA[Karakteristike turbulencije bure (CATURBO), br. 09/151]]></title_hr><title_en><![CDATA[]]></title_en><user_id>11142</user_id><user_firstLast_name>Maja  Telišman Prtenjak</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2014-06</proposal_call><code>DOK-2014-06-6713</code><acronim><![CDATA[]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Geofizika, </scie_field_hr><scie_field_en>Geophysics, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>17750</team_members_id><team_members_names><![CDATA[ Doktorand: Andreina Belušić ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>2590</id><title_hr><![CDATA[Potraga za novim standardnim modelom elementarnih čestica na LHC-u: od preciznih mjerenja elektroslabih procesa do direktnih potraga za novom fizikom]]></title_hr><title_en><![CDATA[]]></title_en><user_id>11164</user_id><user_firstLast_name>Vuko Brigljević</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2014-06</proposal_call><code>DOK-2014-06-8266</code><acronim><![CDATA[]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, </scie_field_hr><scie_field_en>Physics, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>17843</team_members_id><team_members_names><![CDATA[ Doktorand: Benjamin Mesić ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>2591</id><title_hr><![CDATA[Primjena inovativnih tehnologija u proizvodnji biljnih ekstrakata kao sastojaka funkcionalne hrane]]></title_hr><title_en><![CDATA[]]></title_en><user_id>1243</user_id><user_firstLast_name>Verica Dragović-Uzelac</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2014-06</proposal_call><code>DOK-2014-06-9368</code><acronim><![CDATA[IT-PE-FF]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Prehrambena tehnologija, </scie_field_hr><scie_field_en>Food technology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prehrambeno-biotehnološki fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Food Technology and Biotechnology]]></institution_en><team_members_id>17829</team_members_id><team_members_names><![CDATA[ Doktorand: Vanja Plazibat ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[medicinal and aromatic plants, innovative technologies, plant extracts, bioactive compounds, bioavailability, antioxidant properties ]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Medicinal and aromatic plants (MAPs) contain numerous bioactive compounds (BACs) (e.g. polyphenols, carotenoids, organosulphur compounds) that can affect the nutritive, chemical, microbiological, and sensory quality of food products. Additionally, they may provide numerous positive effects to the human health (such as risk reduction for: cardiovascular disease, diabetes, obesity, hypertension etc.). Due to large structural diversity among different groups of BACs and their physical/chemical properties it is important to identify/optimize the most effective extraction methods required to isolate and/or separate them from other plant components. Hence, various innovative extraction techniques (e.g. microwave-, ultrasound- and high-pressure- assisted extraction) will be tested for plant extracts production with high BACs content from selected MAPs grown in Croatia. Each applied extraction technique will be optimized with regards to particular MAP, increasing extraction yield, enhancing quality of extract, shortening extraction time, and decreasing solvent consumption. MAPs extracts and/or BACs will be analyzed for antioxidant properties with application of various assays (e.g. total antioxidant, hydrogen peroxide scavenging, and free radical scavenging, metal chelating activities). Antiproliferative effects against tumor cells and possible protective role from lipid oxidation (including antioxidant activity) will be tested in appropriate cell line model system. The MAP extracts (dried/liquid) and BACs (extracted and/or purified separately or in mixtures) will be studied in animal models for bioavailability; absorption; antioxidant activity; as ingredient for functional food products (fortified beverages and snack bars based on Mediterranean fruits), and for possible use in diabetic/hypercholesteremic management. The obtained results may provide novel opportunities for functional product categories that are likely to have positive benefits on human health.]]></summary_en></project><project>
<id>2592</id><title_hr><![CDATA[Likovna umjetnost i komunikacija moći u razdoblju ranoga novoga vijeka (1450.-1800.) : povijesne hrvatske regije na razmeđi Srednje Europe i Mediterana]]></title_hr><title_en><![CDATA[]]></title_en><user_id>3481</user_id><user_firstLast_name>Mirjana Repanić-Braun</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2014-06</proposal_call><code>DOK-2014-06-7397</code><acronim><![CDATA[VACOP]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Povijest umjetnosti, </scie_field_hr><scie_field_en>Art history, </scie_field_en><institution_hr><![CDATA[Institut za povijest umjetnosti]]></institution_hr><institution_en><![CDATA[Institute of Art History, Zagreb]]></institution_en><team_members_id>4586</team_members_id><team_members_names><![CDATA[ Doktorand: Petra Batelja ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[Art, Politics, Communication, Croatia, Early Modern period]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[This research will primarily focus on the analysis andinterpretation of the relation of pow er holders tow ard the visualarts in Croatian regions of the Early Modern Period, as w ell asthe places and the media of their transmission. In the spirit ofnew art history, the research w ill seek to answ er the follow ingquestions: 1. w hich media channels – including communicationmeans and strategies – did certain centres of pow er use tocreate and promote favourable responses among differenttypes of recipients in Croatia of the early modern period? 2.w hat w as the role of visual art in shaping public opinion and thesocial promotion and re(presentation) of pow er holders? Thepow er holders in Croatian regions w ho acted as artcommissioners w ere primarily from the ranks of the aristocracy(both secular and ecclesiastical) – representatives of the stateideologies of the Venetian Republic, the Kingdom of Hungary,the Habsburg Monarchy and the Dubrovnik Republic. In additionto them, there w ere also local corporate patrons and artcommissioners – confraternities – w hich mainly reflected theinterests of local communities. Those art commissioningchannels made possible cultural transfers in visual arts andarchitecture in the Croatian territory during the period from theearly Renaissance to the late Baroque. The research w illfacilitate the creation of a database containing relevant visualrecords of the aforementioned historical period, w hich w illenable a comparative analysis of the phenomenon from theperspective of the sociology of culture, critical iconology andsemiotics. Finally, this w ill result in the development of anappropriate model for the understanding and interpretation ofthe specific usage of visual arts as mediator in thecommunication of pow er in Croatia of 1450-1800.]]></summary_en></project><project>
<id>2593</id><title_hr><![CDATA[Ekološki pristup projektiranju broda i optimalnom planiranju rute]]></title_hr><title_en><![CDATA[]]></title_en><user_id>4256</user_id><user_firstLast_name>Jasna Prpić-Oršić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2014-06</proposal_call><code>DOK-2014-06-2582</code><acronim><![CDATA[GASDORP]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Brodogradnja, </scie_field_hr><scie_field_en>Naval architecture, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Tehnički fakultet]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Engineering]]></institution_en><team_members_id>19041</team_members_id><team_members_names><![CDATA[ Doktorand: Natalija Vitali ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[seakeeping, ship speed, ship resistance, ship propulsion, fuel consumption, GHG emission, weather routing]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[The accurate calculation of attainable ship speed at actual sea is essential from economical and also environmental aspects. Reliable ship speed loss estimation under real environmental conditions allows a more accurate prediction of the power increase and fuel consumption as well as gas emissions from ships. Nowadays this second issue becomes very important because of the problem of global warming. Following the increasing awareness of the environmental and human health concerns of shipping, legislative actions have been taken on global and national levels making mandatory (from January 1st 2013) that new ships over 400 gross tonnage, to comply with the regulations, should have emissions of CO2 under limiting value. Technological enhancement to ships like improved hull designs as well as improvement in power and propulsion systems could potentially reduce CO2 emission up to 35 %. These measures could effectively be combined with several other operational measures, such as weather routing and voyage planning, in order to ensure that fuel consumption and CO2 emissions from ships are minimized on every voyage.The proposed research will be conducted in three main areas: 1. Improvement of the methodology of ship speed, fuel consumption and greenhouse gases (GHG) emissions (especially CO2) calculation on actual weather conditions, 2. Optimization of the ship hull (bow and stern) and ship propulsion system operating in actual weather condition, 3. Optimization of ship route by taking into account all relevant parameters: weather prediction, attainable ship speed on waves, main engine performance and navigation constrains. The objective is to improve ship design and performance taking into accounts the environmental issue, creating a so called eco-efficient or “green” ship design. The project team consists of the scientists who are experts in the naval architecture, mechanical engineering and marine engineering field which allow solving this problem multidisciplinary. ]]></summary_en></project><project>
<id>2594</id><title_hr><![CDATA[Stohastičke metode u analitičkim i primijenjenim problemima]]></title_hr><title_en><![CDATA[]]></title_en><user_id>145</user_id><user_firstLast_name>Zoran Vondraček</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2014-06</proposal_call><code>DOK-2014-06-3394</code><acronim><![CDATA[SMAAP]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Matematika, </scie_field_hr><scie_field_en>Mathematics, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>19109</team_members_id><team_members_names><![CDATA[ Doktorand: Hrvoje Planinić ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[stochastic methods, stochastic processes, Markov processes, martingales, heavy tails, point processes, branching processes]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[In this project we apply modern stochastic methods to study a number of analytical and applied problems. Many phenomena in science and everyday life exhibit inherent uncertainty. We commonly use stochastic models to describe such behaviour and rely on stochastic methods to gain insights, make forecasts or inference about them. Various stochastic methods have appeared over the years in biology, medicine, biomedicine, geology, climatology, social sciences, finance and insurance, and many other scientific fields. The area of mathematics that lies in the background is probability theory, in particular, theory of stochastic processes. It is a rich mathematical theory with proven potential to solve not only applied problems, but also some quite theoretical problems coming from other areas of mathematics.The problems that we plan to study can be broadly divided into four groups: 1. Analysis and potential theory of Markov processes, 2. Stochastic methods in modelling heavy tailed phenomena, 3. Stochastic methods in harmonic analysis, and 4. Stochastic methods in biomedical and social sciences problems. This choice of problems is influenced by importance in the current international research as well as the background and expertise of members of our team. The goal of the project is to advance understanding of the role of randomness in each of these four settings. The unifying feature behind our approach to these problems is common stochastic methods in their analysis. These methods include, but are not limited to, martingale methods, point processes and random measure methods, potential-theoretic methods (both probabilistic and analytic), Markov processes methods, methods from the Dirichlet form theory, stochastic integrals, diffusion processes, branching processes and measure-valued processes methods, time-series methods, wavelets and methods for statistical inference.]]></summary_en></project><project>
<id>2595</id><title_hr><![CDATA[OIKONET- A Global Multidisciplinary Network on Housing Research and Learning ]]></title_hr><title_en><![CDATA[]]></title_en><user_id>7459</user_id><user_firstLast_name>Gojko Bežovan</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2014-06</proposal_call><code>DOK-2014-06-7086</code><acronim><![CDATA[]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Socijalne djelatnosti, </scie_field_hr><scie_field_en>Social work, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Pravni fakultet u Zagrebu]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Law]]></institution_en><team_members_id>17734</team_members_id><team_members_names><![CDATA[ Doktorand: Josip Pandžić ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>2596</id><title_hr><![CDATA[Genetska osnova količne bioaktivnih hranivih tvari hrvatskih populacija graha]]></title_hr><title_en><![CDATA[]]></title_en><user_id>1294</user_id><user_firstLast_name>Klaudija Carović-Stanko</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2014-06</proposal_call><code>DOK-2014-06-2895</code><acronim><![CDATA[BeanQual]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Biotehnologija, </scie_field_hr><scie_field_en>Biotechnology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Agronomski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Agriculture]]></institution_en><team_members_id>17838</team_members_id><team_members_names><![CDATA[ Doktorand: Monika Vidak ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[Phaseolus vulgaris L., nutrients, bioactive substances, molecular markers, genetic diversity, association mapping]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Common bean is a valuable legume for human consumption worldwide, being an important source of proteins, vitamins and minerals with considerable potential as a functional food. However, the increased mineral content in the diet does not guarantee increased mineral status for consumers and consequently mineral malnutrition is one of the global health concerns. Phytic acid (PA) acts as antinutritive compound by binding mineral cations and forming mixed salts. PA is also the main storage molecule for phosphorus and it is essential for normal seed development and germination. Seed mineral and PA content varies widely among bean genotypes. In Croatia bean is traditionally grown in low input production systems. The production is based on landraces which are adapted to local environments and display high levels of morphological diversity. A broad variability is also expected in seed bioactive nutrient content as well as on genetic level. Through international collaboration on Phaseolus genomics, a lot of information has become available including genetic linkage maps, microsatellite databases and a massive number of single nucleotide polymorphisms (SNP) sequences. In proposed project an integrated approach will be used to characterize bioactive nutrient variability and the inherent genetic diversity. In conjunction with a detailed data on bioactive nutrient content, a whole genome association mapping analysis will be carried out in order to identify quantitative trait loci (QTLs) related to bioactive nutrient content. Success in bean breeding for higher quality relies on the availability of information on bioactive nutrient content and the knowledge of genetic bases of quality trait variability. The integration of fundamental (molecular genetics) and applied (plant nutrition, plant breeding) sciences will facilitate the management of traditional landraces as sources of bioactive nutrients in future breeding programs based on marker-assisted selection (MAS).]]></summary_en></project><project>
<id>2597</id><title_hr><![CDATA[UNESCO-ova katedra za slobodno kretanja osoba, migracije i interkulturalni dijalog (UNESCO Chair on Free Movement of People, Migration and Inter-Cultural Dialogue)]]></title_hr><title_en><![CDATA[]]></title_en><user_id>5506</user_id><user_firstLast_name>Iris Goldner Lang</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2014-06</proposal_call><code>DOK-2014-06-7630</code><acronim><![CDATA[]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Pravo, </scie_field_hr><scie_field_en>Law, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Pravni fakultet u Zagrebu]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Law]]></institution_en><team_members_id>17811</team_members_id><team_members_names><![CDATA[ Doktorand: Nika Bačić ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>2599</id><title_hr><![CDATA[PRIMJENA PLAZME STVORENE VISOKONAPONSKIM ELEKTRIČNIM PRAŽNJENJEM  PRI KONZERVIRANJU TEKUĆE HRANE ]]></title_hr><title_en><![CDATA[]]></title_en><user_id>206</user_id><user_firstLast_name>Zoran Herceg</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2014-06</proposal_call><code>DOK-2014-06-3102</code><acronim><![CDATA[NTP01]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Prehrambena tehnologija, </scie_field_hr><scie_field_en>Food technology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prehrambeno-biotehnološki fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Food Technology and Biotechnology]]></institution_en><team_members_id>590</team_members_id><team_members_names><![CDATA[ Doktorand: VIŠNJA STULIĆ ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[Electrical discharge plasma, liquid-phase plasma reactor, liquid food, physico-chemical properties, nutritional and sensory properties]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[With the growing knowledge of the importance of food in maintaining the human health, the food industry is faced with increasing challenges to develop new non-thermal food treatment technologies that would prevent and mitigate food contamination while retaining nutritional and functional properties of the treated food. Electrical discharge plasma is one of these more promising techniques. Plasmas formed directly in liquid inactivate microorganisms and without significant increase in temperature during the treatment. However, knowledge gaps regarding the nature of sterilization, inactivation mechanism and the plasma reactor design have been identified as major constraints for the applicability of this technology in food industry. Thus the main goal of the proposed project is to design and develop a non-thermal plasma reactor for the treatment of fruit juices and milk and optimize it to maximize the utilization of UV light and chemical species produced by plasma.  To achieve this goal, we propose to address the following research objectives (R):R1     Develop and optimize a liquid-phase plasma reactor for treatment of fruit juices and milk.R2       Characterize the chemical and electrical properties of the liquid plasmas. R3  Evaluate the ability of the liquid-phase plasma to inactivate pathogenic microorganisms in suspensions of pure culture microorganisms and suspended in fruit juices and milk respectively. R4       Determine inactivation mechanism of the plasma treatments on microorganisms R5      Determine the effect of the plasma treatments on the physico-chemical, nutritional and sensory properties of juices and milk.The significance of the proposed research lies in the development of a novel plasma reactor as well as acquires new knowledge regarding the science behind the forthcoming plasma technology which can then be applied towards introducing and potentially replacing current processing technologies with plasma.]]></summary_en></project><project>
<id>2600</id><title_hr><![CDATA[Notch u diferencijaciji hematopoetskih stanica matica i u razvoju leukemija]]></title_hr><title_en><![CDATA[]]></title_en><user_id>3576</user_id><user_firstLast_name>Maja Matulić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2014-06</proposal_call><code>DOK-2014-06-9845</code><acronim><![CDATA[NOBLE]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Biologija, </scie_field_hr><scie_field_en>Biology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>17773</team_members_id><team_members_names><![CDATA[ Doktorand: Luka Horvat ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[ hematopoietic stem cells, leukemia, Notch, Ikaros, non-coding RNA,differentiation, ]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[The relevance of adult (somatic) stem cell research is increasing steeply with a growing number of human diseases shown to be curable by stem cell therapy. The present study plan aims the research towards the gene regulatory mechanisms that control hematopoietic stem cell (HSCs) homeostasis and differentiation, which is tightly regulated by an interplay of a number of transcription factors and environmental signals mediated by a Notch signaling pathway. Our group designed an experimental approach for studying the interaction of Notch signaling pathway with transcription factor genes associated with hematopoiesis with focus on Ikaros gene family. Our laboratory has established a diagnostic technique for quick and sensitive detection of aberrant Notch and Ikaros forms by single cell multiplex qRT-PCR, which is a unique tool enabling us to dissect the contribution of different members of the Ikaros and Notch families on differentiation and survival of hematopoietic cells in a context of regulation of expression of target genes as well as non-coding RNAs, since they maintain the spatial organization of chromosome structure and regulate cell commitment. Our results will improve diagnosis and risk stratification for leukaemia patients which will be an important aid in informed clinical decisions. Therefore the proposed project will substantially advance the field towards better therapeutic options and contribute significantly to the field of stem cell medicine. ]]></summary_en></project><project>
<id>2601</id><title_hr><![CDATA[Kromatografsko pročišćavanje biomolekula i njihova karakterizacija]]></title_hr><title_en><![CDATA[]]></title_en><user_id>102</user_id><user_firstLast_name>Beata Halassy</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2014-06</proposal_call><code>DOK-2014-06-8915</code><acronim><![CDATA[CHROBIO]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Biologija, </scie_field_hr><scie_field_en>Biology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu]]></institution_hr><institution_en><![CDATA[University of Zagreb]]></institution_en><team_members_id>17755</team_members_id><team_members_names><![CDATA[ Doktorand: Dora Sviben ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[chromatography, viruses, plasma proteins, snake venom, monoliths, bioanalytics, aggregation]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Aim of the proposed research is the design of non-invasive chromatographic methods suitable for purification and concentration of biomolecules (viruses and proteins) and their characterization. Purification and analysis methods will be focused on measles virus, snake venom and antivenom proteins, and human plasma proteins. Measles virus is used as a vaccine and is found very suitable as a gene vector and as an oncolytic virotherapeutic, with the last two applications requiring large amounts of the virus. Venom is an antigen for antivenom production and both require careful analysis in order to obtain the final product of high quality. Proteins from plasma, namely albumin and immunoglobulin, are of great medical importance and their purification and stability are of utmost significance. All these biomolecules are important as biotechnological products and are subjected to rigorous quality requirements to ensure their safe usage. Therefore, non-invasive purification methods upgrading their quality and sustainable production and ensuring stability of these fragile biomolecules are essential. This project will base purification on chromatography using monolith stationary phases which are featured by their suitability for biomolecules due to high porosity, high binding capacity and convective based transport. Ion-exchange and affinity chromatography will be employed and various conditions tested for obtaining target material with high purity and yield. Also, various formulation conditions enabling preservation of virus viability and protein functionality and stability throughout the process will be tested. The analysis of the virus infectivity and protein functionality, removal of contaminants and the overall procedure effectiveness will be done by classical biochemical and virological methods as well as by some novel methods such as nanoparticle analysis that enables detection of virus and protein aggregates (NanoSight).]]></summary_en></project><project>
<id>2606</id><title_hr><![CDATA[Konceptualiziranje nacije i kolektivnih identiteta u Hrvatskoj: Politički rituali i kulturalna memorija trauma 20. stoljeća]]></title_hr><title_en><![CDATA[]]></title_en><user_id>2671</user_id><user_firstLast_name>Vjeran Pavlaković</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2014-06</proposal_call><code>DOK-2014-06-1936</code><acronim><![CDATA[FRAMNAT]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Povijest, </scie_field_hr><scie_field_en>History, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Filozofski fakultet u Rijeci]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Humanities and Social Sciences]]></institution_en><team_members_id>17786</team_members_id><team_members_names><![CDATA[ Doktorand: Renato Stanković ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[Cultural memory, war, discourse analysis, collective identity, media]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Commemorations and other political rituals are key components of a nation’s cultural memory, crucial for the construction and reinforcement of ideological, ethnic, economic, gender, and other identities. FRAMNAT will involve a dynamic team of young scholars and develop innovative methodologies for cultural memory research and cognitive linguistics analysis relevant for Croatia’s academic and policy-making community, as well as a much broader transnational audience. Croatia’s commemorative culture regarding the wars of the 20th century serves as a platform for politicians to operate within the nation-building narratives. Our project will analyze both top-down and bottom-up strategies of framing the nation and collective identities through commemorative practices of World War Two and the Homeland War in Croatia.  These discourses will be analyzed at three levels: top-down political discourse (elites), media representation and transmission, and the reception of the narratives in Croatian society (bottom-up reactions). Seven commemorations related to World War 2 and the Homeland War will be observed and analyzed using corpus-based linguistic analysis and frame analysis. The media representations of the commemorative events and opinion poll data will likewise be analyzed in order to map how these discourses are transmitted and received in Croatian society. The project results will be disseminated via a regularly updated website (which includes a database of the collected research materials), journal articles, an edited volume, and papers presented at international conferences. Students and other members of the scholarly community will be encouraged to participate in the project through a variety of workshops to be held at the University of Rijeka. The long-term goal is to develop a Cultural Memory Research Center with scientific methods which can be applied to other regional and international case studies.    ]]></summary_en></project><project>
<id>2609</id><title_hr><![CDATA[ANAGENNISI - Innovative Reuse of All Tyre Components in Concrete]]></title_hr><title_en><![CDATA[]]></title_en><user_id>3406</user_id><user_firstLast_name>Nina Štirmer</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2014-06</proposal_call><code>DOK-2014-06-1679</code><acronim><![CDATA[]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Temeljne tehničke znanosti, </scie_field_hr><scie_field_en>Basic engineering sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Građevinski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Civil Engineering]]></institution_en><team_members_id>17806</team_members_id><team_members_names><![CDATA[ Doktorand: Martina Pezer ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>2610</id><title_hr><![CDATA[Ekonomski, statistički i politički aspekti tržišta državnih obveznica]]></title_hr><title_en><![CDATA[]]></title_en><user_id>603</user_id><user_firstLast_name>Maruška Vizek</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2014-06</proposal_call><code>DOK-2014-06-9058</code><acronim><![CDATA[SOBOM]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Ekonomija, </scie_field_hr><scie_field_en>Economy, </scie_field_en><institution_hr><![CDATA[Ekonomski institut Zagreb]]></institution_hr><institution_en><![CDATA[Institute of Economics in Zagreb]]></institution_en><team_members_id>17742</team_members_id><team_members_names><![CDATA[ Doktorand: Petra Palić ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[Sovereign bond market, sovereign spreads, volatility spillovers, sovereign bond market integration stochastic volatility models, extreme value theory,]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Recent developments related to the Eurozone debt crisis clearly demonstrated the inability of the literature to provide a theory and associated empirical models that can explain the past and predict the future sovereign bond yield changes. Therefore in this research we investigate the features of the sovereign bond markets that are either underexplored or the literature offers conflicting findings. We focus specifically on bond markets in all EU member states and the US, and differentiate seven research segments that are mutually interrelated. First segment applies GARCH-type models and estimates sovereign bond spread volatility and the volatility risk premium. The output of this segment is used in subsequent segments; in the model of spread determinants, volatility spillovers, and capital flight. Second segment is dedicated to the analysis of the statistical properties of sovereign spreads volatility by an application of extreme value theory, self-exciting and Markov switching models. We quantify extremal dependence between spreads and the distribution of  clusters of their extreme movements using the extremogram. Two segments are devoted to the analysis of volatility spillovers across bond markets and time-varying degree of sovereign bond market integration in developed and emerging EU countries. We also analyze political factors that may influence the sovereign bond market and cross-border capital movement. In this segment we code political variables employed as explanatory variables in the remaining two segments. Hence segment six estimates the model of spread determinants that includes a more balanced and detailed representation of market sentiment and volatility, fiscal features, and political factors. Due to the fact that in recent times extreme changes in sovereign bond markets induced cross-border reallocation of the capital, in the seventh segment we estimate a capital flight model that includes political factors and sovereign spread volatility premium.]]></summary_en></project><project>
<id>2613</id><title_hr><![CDATA[Eksperimentalno potpomognuti razvoj naprednih modela izgaranja motora s unutarnjim izgaranjem ]]></title_hr><title_en><![CDATA[]]></title_en><user_id>11160</user_id><user_firstLast_name>Darko Kozarac</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2014-06</proposal_call><code>DOK-2014-06-5314</code><acronim><![CDATA[]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Strojarstvo, </scie_field_hr><scie_field_en>Mechnical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet strojarstva i brodogradnje]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Mechanical Engineering and Naval Architecture]]></institution_en><team_members_id>17793</team_members_id><team_members_names><![CDATA[ Doktorand: Mario Sremec ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>2614</id><title_hr><![CDATA[Mjerenje svojstava Higgsovog bozona i potraga za novom fizikom detektorom CMS]]></title_hr><title_en><![CDATA[]]></title_en><user_id>4052</user_id><user_firstLast_name>Ivica Puljak</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2014-06</proposal_call><code>DOK-2014-06-2568</code><acronim><![CDATA[HIGGSPRO]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, </scie_field_hr><scie_field_en>Physics, </scie_field_en><institution_hr><![CDATA[Sveučilište u Splitu, Fakultet elektrotehnike, strojarstva i brodogradnje]]></institution_hr><institution_en><![CDATA[University of Split, Faculty of Electrical Engineering, Mechanical Engineering and Naval Architecture]]></institution_en><team_members_id>19070</team_members_id><team_members_names><![CDATA[ Doktorand: Toni Šćulac ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[CMS detector, LHC, Higgs boson, leptoquarks, electron reconstruction]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[The discovery of a Higgs boson by the ATLAS and CMS experiments at the LHC has opened a new era for particle physics, namely precision consistency tests of the SM Higgs boson. The proposed project has two main goals: measurement of the SM Higgs boson properties, as the window for the search for new physics beyond the Standard model, and a direct search for new physical phenomena looking for hypothetical particles called leptoquarks. In the first year of project we will explore the data collected by the CMS experiment during 2011 and 2012, while preparing for the LHC Run II, which is expected to start in 2015. Preparation consists of developing and implementing new electron reconstruction, identification and isolation algorithms, which will be used by the whole collaboration when the new data taking starts.  During the second year of the project we will commission and maintain electron reconstruction algorithms, start collecting the data and make first analysis at new energy. During third and fourth year we will explore the data and concentrate to the two main goals of the project: SM Higgs boson properties measurements and search for new physics. ]]></summary_en></project><project>
<id>2615</id><title_hr><![CDATA[Inženjering kristalnih materijala pomoću metalnih kompleksa i nekovalentnih interakcija]]></title_hr><title_en><![CDATA[]]></title_en><user_id>1229</user_id><user_firstLast_name>Marijana Đaković</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2014-06</proposal_call><code>DOK-2014-06-9090</code><acronim><![CDATA[CRYSTIN]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, </scie_field_hr><scie_field_en>Chemistry, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>17739</team_members_id><team_members_names><![CDATA[ Doktorand: Mladen Borovina ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[crystal engineering, non-covalent interactions, supramolecular architecture, synthons, metal complexes]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Interdisciplinary research at the interface of chemistry and materials science has been remarkably successful at producing technologies that have revolutionized all aspects of everyday life.  However, there is still a great need for new solids with ‘improved’ physical properties (faster, cheaper, smarter or more responsive than current alternatives). Unfortunately, the ability to ‘dial-in’ a property or physical response remains a major challenge. Therefore, our goal is to establish reliable avenues for the design of crystalline metal-containing materials by encoding building-blocks with structural-preferences that lead to ‘programmable’ assembly, thus avoiding serendipity and chance when targeting new materials with specific and tunable properties. To achieve this, we first need to map out the structural landscape that controls how metal complexes communicate and subsequently assemble into 3-D architectures.We will explore and quantify the interrelationship between ligand-field splitting energy, coordination geometry, metal-ligand dimensionality, ligand flexibility, and supramolecular assembly, one variable at a time, using a combination of experiment and theory.  This will enable us to map out the structural landscape defined by metal(II) complexes (Co, Ni, Cu and Cd) and custom-made ligands decorated with functionalities that are known to form reliable supramolecular synthons in organic solids.New structural and spectroscopic information will be complemented by data obtained by mining the CSD, while computational methods will inform both the planning as well as the interpretation of the experimental efforts. The results obtained in this systematic and multidisciplinary research program will create new avenues towards the design of crystalline metal-containing materials based on reliable structure-activity protocols.]]></summary_en></project><project>
<id>2616</id><title_hr><![CDATA[Modeli i metode upravljanja inovacijama u razvoju kompleksnih inženjerskih sustava]]></title_hr><title_en><![CDATA[]]></title_en><user_id>4471</user_id><user_firstLast_name>Mario Štorga</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2014-06</proposal_call><code>DOK-2014-06-2035</code><acronim><![CDATA[MInMED]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Strojarstvo, </scie_field_hr><scie_field_en>Mechnical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet strojarstva i brodogradnje]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Mechanical Engineering and Naval Architecture]]></institution_en><team_members_id>17795</team_members_id><team_members_names><![CDATA[ Doktorand: Marija Majda Perišić ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[innovation dynamics, knowledge management , socio-technical systems, complex networks, engineering systems development]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[The goal of the proposed research project is to develop a set of fundamental models and methods for innovation management within and across hierarchical social networks exiting in contemporary private and public R&D organisations, and to explore and develop analyse and simulation tools for quantifying knowledge and information dynamics as a mean for prediction of the future trends in organisational innovation. The context of the socio-technological framework that transcends the organisational innovation dynamics within contemporary engineering systems and services life-cycle requires the research overriding commitment to methodological pluralism. The integrated analyse – evaluate - create – refine - validate approach will be used as research methodology.The research will build on state of the art developments in the exploration of principles of knowledge management for R&D organisations and will go further; in that it will seek to incorporate the insights from modelling, simulation and visualisation of the complex social, natural and technical systems to the knowledge and information dynamics that encompass the generation, storage, dissemination, filtering, and reprocessing of innovation across hierarchical socio-technological networks. The research effort will entail the development of concepts, theories, metrics and case studies related to the R&D organisational innovation management. The controlled experiments in real-world private and public R&D organisations will be used in research to gain valuable insights across different sectors (automotive, aerospace, energy, transportation, healthcare, public administration, etc.).It is expected that the results of the proposed research will provide valuable interdisciplinary contributions and improve overall understanding respective to the organisational innovation.]]></summary_en></project><project>
<id>2619</id><title_hr><![CDATA[Upotreba cijelog genoma mitohondrijske DNA u oplemenjivanju i konzervacijskoj genetici goveda]]></title_hr><title_en><![CDATA[]]></title_en><user_id>6650</user_id><user_firstLast_name>Ino Čurik</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2014-06</proposal_call><code>DOK-2014-06-8455</code><acronim><![CDATA[MitoTAUROmics]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Poljoprivreda, </scie_field_hr><scie_field_en>Agriculture, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Agronomski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Agriculture]]></institution_en><team_members_id>19007</team_members_id><team_members_names><![CDATA[ Doktorand: Vladimir Brajković ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[Whole mitogenome, Cattle, Detrimental effects, Phenotypic variability, Quantitative genetics]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[The main goal of this proposal is to sequence mitochondrial whole genome (mtWGS) in a 500 to 600 bulls or cows (440 to 540 belonging to Istrian cattle, Busha cattle, Slavonian-Syrmian Podolian cattle and Holstein population in Croatia) in order to: 1). identify polymorphic sites within mtWGS in genetically small populations and to analyse (confirm) the presence of selection for the whole mitochondrial genome as well as for each single gene (comparison of non-synonymous versus synonymous mutations); 2). Identify potentially detrimental mutations and to estimate detrimental load in all analysed populations; 3.) develop computerised approach (set of algorithms) that will, in terms of probability or likelihood, enable imputation of sequenced mtWGS haplotypes for other pedigree members as well as to point to animals that are wrongly assigned to the pedigree, 4.) Identify mutations that are associated with phenotypic variability of milk production and fertility traits and to estimate the magnitude of the mtWGS effects (haplotypes) in terms of variance components and 5.) Identify private (specific) mutations that can be used in traceability or genetic bar-coding of species and breeds (this is of particular interest for endangered populations). In performing these comprehensive analyses we will use newly developed methodologies of high-throughput sequencing and complex computing analyses. We believe that this research will stimulate other researchers involved in animal genetics and breeding of other species (dog, horse, swine, rabbit, etc…) for similar researches. Furthermore, results of the project will be economically utilised in cattle breeding as well as conservation management of endangered Croatian breeds. At the same time, we hope that innovative and technologically advanced component of this research will result in good publication record for all scientists involved which will further increase our competitiveness to approach to EU funded projects.]]></summary_en></project><project>
<id>2620</id><title_hr><![CDATA[Održiva proizvodnja bioetanola i biokemikalija iz otpadnih poljoprivrednih lignoceluloznih sirovina]]></title_hr><title_en><![CDATA[]]></title_en><user_id>450</user_id><user_firstLast_name>Tonči Rezić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2014-06</proposal_call><code>DOK-2014-06-4937</code><acronim><![CDATA[SPECH-LRM]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Biotehnologija, </scie_field_hr><scie_field_en>Biotechnology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prehrambeno-biotehnološki fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Food Technology and Biotechnology]]></institution_en><team_members_id>17840</team_members_id><team_members_names><![CDATA[ Doktorand: Martina Andlar ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[bioetahnol, lactic acid, physiological active oligosaccharides, lignocellulosic raw materials, integrated bioprocess, mathematical modeling, LCA]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[The aim of this project proposal is the development of sustainable bioprocesses for the production of bioethanol and biochemicals [lactic acid (LA) and physiologically active oligosaccharides (PAO)] from agricultural waste lignocellulosic raw materials (e.g. wheat straw, corn stover and cob, onion peels, cocoa husks, pea pods, walnut shells and sugar beet pulp). All these agricultural byproducts are abundant, cheap, non-food competing and renewable polysaccharide-based feedstocks.  In this project, agricultural waste lignocellulosic raw materials will be hydrolyzed by thermal, chemical or enzymatic methods or their combinations in order to obtain adequate disintegration of raw materials. Studies of bioethanol and LA production will be performed by the semi-solid or solid state fermentation in the new constructed horizontal rotating tubular bioreactor (HRTB). The most suitable microorganisms for bioetahnol and LA production will be identified and improved by genetic methods. Studies regarding suitable purification methods for all three bio-products will be performed in order to obtain pure compounds for theirs further practical use. Integration between production and separation bioprocess stages will be also examined in order to improve ecological and economical aspects of these bioprocesses. The sustainability of bioethanol and LA production will be evaluated through the realization of Life Cycle Assessment (LCA). The most efficient and sustainable bioprocess configuration will be determined and consequently scale-up procedure will be proposed. The scale-up procedure will be based on the developed integral bioprocess mathematical model and other scale-up criteria. Project outcomes will be new integrated bioprocesses for the transformation of agricultural waste lignocellulosic raw materials into high added value products.]]></summary_en></project><project>
<id>2621</id><title_hr><![CDATA[Metode deidentifikacije za meke i ne-biometrijske identifikatore]]></title_hr><title_en><![CDATA[]]></title_en><user_id>6564</user_id><user_firstLast_name>Zoran Kalafatić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2014-06</proposal_call><code>DOK-2014-06-9838</code><acronim><![CDATA[DeMSI]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Računarstvo, </scie_field_hr><scie_field_en>Computer sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id>6563</team_members_id><team_members_names><![CDATA[ Doktorand: Ivan Filković ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[De-Identification, Privacy Protection, Image Processing, Video Processing, Biometrics, Multimedia]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Advances in audio and video recording devices, web technology and signal processing have highly facilitated the efficacy of audio and video acquisition. This capability is now widely exploited in a variety of scenarios to obtain audio-video recordings of people, raising serious privacy concerns. The protection of sensitive private data is required by EU’s Data Protection Directive (95/46/EC). De-identification in multimedia content can be defined as the process of concealing identities of individuals captured in a given set of data, for the purpose of protecting their privacy. Soft biometric and non-biometric characteristics such as tattoos, birthmarks, scars or dressing style also carry potentially identity-revealing information and have to be dealt with in the process of de-identification. This is an interdisciplinary challenge, involving such scientific areas as image processing, video tracking and biometrics. This project proposal aims to development of novel and robust methods for de-identification of soft and non-biometric identifiers in videos and images.]]></summary_en></project><project>
<id>2622</id><title_hr><![CDATA[Europska bioetika na djelu]]></title_hr><title_en><![CDATA[]]></title_en><user_id>4099</user_id><user_firstLast_name>Amir Muzur</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2014-06</proposal_call><code>DOK-2014-06-2024</code><acronim><![CDATA[EuroBioAct]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Medicine]]></institution_en><team_members_id>5496</team_members_id><team_members_names><![CDATA[ Doktorand: Robert Doričić ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[Europe, integrative bioethics, Fritz Jahr, ecology, environment, Northern Adriatic]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[The „European Bioethics in Action (EuroBioAct)” project primarily aims at:	1. completing theoretical basis for the „new European bioethics“ (by rounding-up 	research on Fritz Jahr, Ignaz Bregenzer, and other thinkers and conceiving a 	common platform with integrated ideas of modern environment science and 	ethics) and	2. applying that theoretical basis in practice (by compiling a list of „bioethical 	standards“ for settlements, containing concrete general and specific norms for 	preservation and improvement of local eco-systems – i.e., human health, animal 	and plant welfare, etc.).In the first phase of the project realisation, the participants would continue with the broadening and deepening of the theoretical basis of the „new European bioethics“ primarily by completing the research of the life and work of Fritz Jahr and his most important models (Ignaz Bregenzer and others). In the second phase of the project, three focused workshops would be organised determining the status of the general and special ecological needs for the three local communities (Plomin, Bakar, and Mali Lošinj) from the Northern Adriatic region. The three communities selected to host the workshops have either been recently experiencing ecological threats (Plomin – thermo-electric power plant; Bakar – cokery), or represent a highly-valuable and vulnerable natural insular pocket (Mali Lošinj – health tourism, dolphin wildlife refuge, fragrant gardens programme, etc.). Based on the theoretical background and the insights provided by the workshops, in the third phase of the project, created would be the „bioethical standards“, that is, a set of principles and measures of the correct relation of men toward their own health, animals, plants, and the eco-system in total. A „bioethical standards“ charter might improve the level of local community environmental consciousness, and provide direction lines for its sustainable development (including a potential tourism-advertising ace card).]]></summary_en></project><project>
<id>2623</id><title_hr><![CDATA[Epigenetičke promjene karcinoma pločastih stanica glave i vrata]]></title_hr><title_en><![CDATA[]]></title_en><user_id>572</user_id><user_firstLast_name>Magdalena Grce </user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2014-06</proposal_call><code>DOK-2014-06-3542</code><acronim><![CDATA[EpiC-HNSCC]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>17822</team_members_id><team_members_names><![CDATA[ Doktorand: Ksenija Božinović ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[methylation, microRNA, HPV, head and neck cancer, biomarker]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Head and neck squamous cell carcinoma (HNSCC) is the sixth most common malignancy worldwide. Despite aggressive treatment of HNSCC patients, which entails surgery, chemo- and radio-therapy, the five-year survival is only 40-50%. Tobacco, alcohol, microbial factors (high-risk human papillomaviruses, hrHPVs), systemic factors (immunosuppression, micronutrient deficiency) and UV-radiation are common risk factors for development of HNSCC. HNSCC patients with HPV infection were found to have better prognosis and treatment response. Besides the HPV status, no adequate biomarkers have been found so far to predict the poor/good clinical outcome nor is the mechanism of how HPV modulates therapy response fully understood. Epigenetic changes such as DNA methylation of specific gene promoters and posttranscriptional modification of gene expression by specific microRNA (miRNA) seems to be promising biomarkers of disease occurrence and progression. Therefore, the primary objective of this project is to identify novel specific epigenetic biomarkers to predict early-stage of HNSCC, notably oral and oropharyngeal cancer, patients at greater risk for developing invasive cancer, and finally understand treatment response in patient with HPV-associated cancers. State-of-the-art technologies, wide-genome microarray assay and types-specific validation of DNA methylation and miRNA profiles (methylome and mirome, respectively) will be used on subsets of healthy tissue, HPV-related and HPV-unrelated precancerous oral lesions, oral and oropharyngeal cancer, and metastasis. The integration of all findings should yield ideal epigenetic biomarkers. This project is a comprehensive interdisciplinary research, which includes basic and clinical research, and will enable the improvement of existing knowledge, development of new technological approaches in diagnostics and prognostics, and possible new treatment approach for oral and oropharyngeal cancer.]]></summary_en></project><project>
<id>2624</id><title_hr><![CDATA[Identifikacija i funkcionalna karakterizacija (eko)toksikološki važnih polispecifičnih membranskih transportnih proteina u zebrici (Danio rerio)]]></title_hr><title_en><![CDATA[]]></title_en><user_id>986</user_id><user_firstLast_name>Tvrtko Smital</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2014-06</proposal_call><code>DOK-2014-06-7922</code><acronim><![CDATA[TRANS-ZEBRATOX]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Biologija, </scie_field_hr><scie_field_en>Biology, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>17738</team_members_id><team_members_names><![CDATA[ Doktorand: Jelena Dragojević ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[polyspecific uptake and efflux transporters, zebrafish, identification, functional characterization, knockout studies, (eco)toxicological relevance ]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[A coordinated system of transport proteins, channels, receptors and enzymes act as cellular gatekeepers to foreign molecules, critically determining the so-called ADME-Tox (absorption, distribution, metabolism, excretion – toxicity) properties of a molecule. The polyspecific uptake and efflux transmembrane proteins are essential components of this complex cellular defense and detoxification/xenobiotic processing machinery in mammals, highly important and widely recognized in the context of pharmacology and human toxicology. However, they are scarcely investigated in non-mammalian species, and not adequately addressed in the field of environmental toxicology. Consequently, the major goal of the proposed project is identification and detailed functional characterization of new, potentially (eco)toxicologically relevant uptake and efflux transport proteins not addressed so far in the context of environmental toxicology, or in non-mammalian species in general. Our research will be focused on selected polyspecific uptake transport proteins from the SLC21 and SLC22 (Solute Carriers) proteins families, the efflux transporters from the MATE (multidrug and toxic compound extrusion proteins) family, and finally the RLIP76 as the most recently discovered stress-responsive, multi-functional membrane protein. We will use zebrafish (Danio rerio) as a highly relevant vertebrate research model, and our methodological approach will be based on several subsequent research phases: phylogenetic and gene expression analyses; transfection studies in appropriate heterologous expression system(s); transport-activity assays; analyses of the transport mechanism and structural properties; high-throughput-screening identification of chemical interactors of selected transporters among environmental contaminants; and finally in vivo evaluation of the (eco)toxicological relevance of selected transporters using the zebrafish functional genomics tools.]]></summary_en></project><project>
<id>2625</id><title_hr><![CDATA[Istraživaje prirodnih spojeva i aroma: kemijsko profiliranje i otkrivanje potecijala]]></title_hr><title_en><![CDATA[]]></title_en><user_id>367</user_id><user_firstLast_name>Igor Jerković</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2014-06</proposal_call><code>DOK-2014-06-3039</code><acronim><![CDATA[NaPro-Flav]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, </scie_field_hr><scie_field_en>Chemistry, </scie_field_en><institution_hr><![CDATA[Sveučilište u Splitu, Kemijsko-tehnološki fakultet]]></institution_hr><institution_en><![CDATA[University of Split, Faculty of Chemistry and Technology]]></institution_en><team_members_id>3752</team_members_id><team_members_names><![CDATA[ Doktorand: Marina Kranjac ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[natural products, flavours, preparative techniques, chromatography, spectroscopy, antioxidant assays, corrosion inhibition assays]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[The proposed project develops up-to date topic in the subject area, offers high-quality research of natural products (NPs) and flavours (FLs) and tends to impact the biodiversity, traceability and authentication issues of targeted samples (major EU concerns), as well as to unlock the potential (useful activities of the samples/NPs). Targeted samples are unexplored or insufficiently investigated honeys, honeydews, bee-products, wines, cheese, others. While characteristic NPs (secondary metabolites) already possess flavours, other flavour compounds can derive from precursors during processing, fermentation, dry-curing, heating, others (e.g. Maillard reactions, Strecker degradations, retro-aldol reactions, Amadori rearrangements, heterocyclizations, lipid oxidations and others). NPs/FLs isolation involves application of selective preparative procedures followed by the organic analysis applying modern chromatographic and spectroscopic techniques. Specific project goal is to determine reliable chemical fingerprints of targeted samples depending on biodiversity of natural sources in different regions. Varieties of acetate, shikimate, mevalonate and/or deoxyxylulose biosynthetic pathway derivatives are expected to be found. Among them, it can be possible to find specific or nonspecific chemical biomarkers characterizing certain sources. In addition, the obtained NPs or selected samples will be evaluated in order to unlock their potential, particularly antioxidant activity by different assays and corrosion inhibition potential with in-situ and ex-situ electrochemical/non-electrochemical techniques. Project work plan includes: 1) the samples selection and preliminary characterisation; 2) set-up of preparative/chromatographic/spectroscopic methods followed by elaboration of the obtained chemical fingerprints); 3) set-up of antioxidant/corrosion inhibition assays followed by unlocking the samples/NPs potential; 4) training of young researchers/cooperation.]]></summary_en></project><project>
<id>2626</id><title_hr><![CDATA[Primjena nanomaterijala u izradi potenciometrijskih tenzidnih senzora za primjenu u industriji i zaštiti okoliša]]></title_hr><title_en><![CDATA[]]></title_en><user_id>4824</user_id><user_firstLast_name>Milan Sak-Bosnar</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2014-06</proposal_call><code>DOK-2014-06-8713</code><acronim><![CDATA[NANOSENS]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, </scie_field_hr><scie_field_en>Chemistry, </scie_field_en><institution_hr><![CDATA[Sveučilište Josipa Jurja Strossmayera u Osijeku, Odjel za kemiju]]></institution_hr><institution_en><![CDATA[Josip Juraj Strossmayer University of Osijek, Department of Chemistry]]></institution_en><team_members_id>17818</team_members_id><team_members_names><![CDATA[ Doktorand: MATEJA HAJDUKOVIĆ ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[surfactant, analysis, sensor, potentiometry, nanomaterial, environment, industry]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[The project comprises development and construction of a nanomaterials-based potentiometric surfactant sensor, that will be used for measurement of ionic surfactants concentration in surfactant raw materials, consumer products, pharmaceutical and cosmetic products, environmental materials etc. The new sensor should eliminate the drawbacks of the standard time-consuming extraction-spectrophotometric procedures and classical polymer liquid membrane based sensors. It can be used as an end-point detector by potentiometric titration of ionic surfactants or by their direct potentiometric determination.The new sensor can be also used as a specific detector in microfluidic techniques such as Flow Injection Analysis (FIA), Sequential Injection Analysis (SIA), as well as in the separation techniques (HPLC), substituting in this way more expensive, larger nonspecific detectors such as optical and conductivity detectors etc.]]></summary_en></project><project>
<id>2627</id><title_hr><![CDATA[Establish Pan-European Information Space to Enhance seCurity of Citziens - EPISECC]]></title_hr><title_en><![CDATA[]]></title_en><user_id>11139</user_id><user_firstLast_name>Snježana Knezić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2014-06</proposal_call><code>DOK-2014-06-6635</code><acronim><![CDATA[]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Temeljne tehničke znanosti, </scie_field_hr><scie_field_en>Basic engineering sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Splitu Fakultet građevinarstva, arhitekture i geodezije]]></institution_hr><institution_en><![CDATA[University of Split, Faculty of Civil Engineering, Architecture and Geodesy]]></institution_en><team_members_id>17807</team_members_id><team_members_names><![CDATA[ Doktorand: Toni Kekez ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>2628</id><title_hr><![CDATA[Primjena nusproizvoda prehrambene industrije za razvoj funkcionalnih i okolišno prihvatljivih ekstrudiranih proizvoda i aditiva ]]></title_hr><title_en><![CDATA[]]></title_en><user_id>6031</user_id><user_firstLast_name>Drago Šubarić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2014-06</proposal_call><code>DOK-2014-06-5131</code><acronim><![CDATA[FUNEXFOOD]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Prehrambena tehnologija, </scie_field_hr><scie_field_en>Food technology, </scie_field_en><institution_hr><![CDATA[Sveučilište Josipa Jurja Strossmayera u Osijeku, Prehrambeno-tehnološki fakultet]]></institution_hr><institution_en><![CDATA[Josip Juraj Strossmayer University of Osijek, Faculty of Food Technology]]></institution_en><team_members_id>17789</team_members_id><team_members_names><![CDATA[ Doktorand: Jelena Panak ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[Functional food, extrusion, cereals, flours, by-products, environment-friendly]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Consumers nowadays are seeking palatable food which has beneficial effect on health. At the same time, they are not ready to change their eating habits – reduce intake of bakery products, fast food etc. and increase intake of fresh fruit and vegetable, whole grain products etc. Therefore, food industry is challenged to create products that are consumed every day (bread, snacks etc.) by large population, which are both enriched with bioactive substances and have desired sensory properties.The aim of this project is to develop new functional and enriched products based on extrusion process. Enriched grains (wheat, maize) will be used as basic material. The improvement and supplementation with biologically active (antioxidants, minerals, vitamns, fibre) will be done by addition of by-products from food industry (fruit and vegetable pomaces, oil cakes) in extrusion process. Extrusion will be used to produce final products: expanded snack products and pasta, as well as modified flours which will be used in production of bakery products and biscuits.All processes - extrusion of snack products and pasta, extrusion for flour modification, pasta drying, baking) will be optimised using response surface methodology. All products will be tested for chemical, physical, thermophysical properties, and optimal products will be sensory analysed.The results of project will be array of flours and final products with defined recipes and optimal production conditions, along with defined application of food industry by-products that significantly load environment and are not currently exploited to satisfying extent.In the project multidisciplinary approach will be applied – from agronomist, over food technologist and process engineers to sensory experts. In addition, close academia-industry links will be developed through different activities.]]></summary_en></project><project>
<id>2629</id><title_hr><![CDATA[Advancing the European Multilingual Experience (AThEME)]]></title_hr><title_en><![CDATA[]]></title_en><user_id>5463</user_id><user_firstLast_name>Tihana Kraš</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2014-06</proposal_call><code>DOK-2014-06-4334</code><acronim><![CDATA[]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Filologija, </scie_field_hr><scie_field_en>Philology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Filozofski fakultet u Rijeci]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Humanities and Social Sciences]]></institution_en><team_members_id>24274</team_members_id><team_members_names><![CDATA[ Doktorand: Maša Plešković ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>2631</id><title_hr><![CDATA[Poluvodički elementi visokih performansi  za primjene u sklopovima za bežične komunikacije i optičke detektore]]></title_hr><title_en><![CDATA[]]></title_en><user_id>6955</user_id><user_firstLast_name>Tomislav Suligoj</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2014-06</proposal_call><code>DOK-2014-06-2113</code><acronim><![CDATA[HiPerSemi]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Elektrotehnika, </scie_field_hr><scie_field_en>Electrical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id>17830</team_members_id><team_members_names><![CDATA[ Doktorand: Sabina Krivec ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[semicoductors, microelectronics, bipolar transistors, photodetectors, photodiodes, CMOS, modeling, MOSFET, RF circuits]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[The objective of this project is to provide notable scientific contributions by designing and utilizing the advanced semiconductor devices for the wireless communication circuits and solid-state optical detection applications. Research in this project will be grouped in three major activities, which are: (i) Horizontal Current Bipolar Transistor (HCBT) for RF Wireless Circuits, (ii) Characterization and applications of solid-state photodetectors, and (iii) Modelling of MOS, photodetector and other advanced electron devices. The novel wireless RF communication circuits such as mixer, frequency divider, voltage-controlled oscillator, RF switch and power amplifier will be designed and fabricated in HCBT technology as the first such circuits using the HCBT as an active component. The measurements of noise, reliability and on-wafer uniformity as well as linearity, gain and efficiency will be performed on transistors and circuits. The characterization of material properties of pure amorphous boron (PureB) layers will be made in order to determine the composition, electrical and optical properties of the layer and to develop the model of charge carrier transport through it. They will be correlated with electrical measurements to find out currently-unknown physical mechanisms responsible for the current reduction and for the record-high performance of photodides with PureB layers. The investigation of the novel materials such as Ge, SiGe and GaN for ultra-scaled advanced CMOS structures, i.e. FinFETs, will be performed by the development of novel models and simulation environment. The analog/RF parameters and characteristics will be extracted for FinFETs with different geometries and materials in order to determine the optimum structure for future RF systems.]]></summary_en></project><project>
<id>2632</id><title_hr><![CDATA[Komunikacije usmjerene čovjeku u pametnim mrežama]]></title_hr><title_en><![CDATA[]]></title_en><user_id>5079</user_id><user_firstLast_name>Ivana Podnar Žarko</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2014-06</proposal_call><code>DOK-2014-06-9476</code><acronim><![CDATA[HUTS]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Računarstvo, </scie_field_hr><scie_field_en>Computer sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id>17866</team_members_id><team_members_names><![CDATA[ Doktorand: Martina Marjanović ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[smart network, big data, cloud communications, human computer interface, internet of things]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Human-centric Communications in Smart Networks (HUTS) project will address open questions regarding smart networks and human-centric communication in which data is both gathered from – and provided to – humans, anywhere and at any time, responding to their current needs. Through its research objectives, the project will investigate networking aspects of human-centric communication, such as the allocation and optimization of cloud and network resources and also providing related quality of service guarantees. This research will be used as a building block for various smart services, which enable user and device adaptation based on learning from previous situations and communicating the results of these situations. This powerful concept relies on new methods in cloud computing for big data processing and Internet-connected objects, such as smart sensors and actuators, as well machine-to-machine communication between devices using self-organizing ad-hoc networks. Smart services are further built upon innovative complex-service composition methodology and intelligent mechanisms to be formulated by the project. The introduction of smart services will drive the changes in the way people interact with devices towards more intuitive and unconstrained means. In particular, contactless user interaction, considering various categories of users, and networked virtual worlds/environments will be studied. Network data traffic models and network management will be proposed, including online charging mechanisms for dynamic pricing and cost calculation of smart services. The research proposed in this project will create new knowledge, strengthen research mentoring and improve young scientist capacities in Croatia, contribute results to science in the area of Information and Communication Technology, and help develop Croatian scientific and research space as one of the long-term strategic priorities, enabling knowledge transfer to Croatian economy for the benefit of society.]]></summary_en></project><project>
<id>2633</id><title_hr><![CDATA[Procjena i predviđanje produktivnosti šumskog ekosustava objedinjavanjem terenskih izmjera, daljinskih istraživanja i modeliranja]]></title_hr><title_en><![CDATA[]]></title_en><user_id>360</user_id><user_firstLast_name>Hrvoje Marjanović</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2014-06</proposal_call><code>DOK-2014-06-9721</code><acronim><![CDATA[EFFEctivity]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Šumarstvo, </scie_field_hr><scie_field_en>Forestry, </scie_field_en><institution_hr><![CDATA[Hrvatski šumarski institut]]></institution_hr><institution_en><![CDATA[Croatian Forest Research Institute]]></institution_en><team_members_id>17816</team_members_id><team_members_names><![CDATA[ Doktorand: Mislav Anić ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[forest productivity, Quercus robur, GPP, NPP, eddy covariance, MODIS, Biome-BGC, photogrammetry, dendrometers, soil respiration]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Forest play important role in climate regulation and secure resources vital for local economy,  but the imminent climate change will affect their productivity, and for some tree species possibly even their sustainability. Thus, monitoring forest productivity and understanding effects of key environmental drivers becomes essential for forest management. This is a challenging task, particularly due to great costs related to it. Hereby we propose a research, aimed at addressing this issue, with a novel approach that could facilitate fast and cost-effective assessments of forest productivity. The research would be conducted on pedunculate oak forests (Quercus robur L.) which are economically, and ecologically, one of the most important in Croatia.  Main objective of the proposed research is to develop and test methods and workflows for the estimation of annual productivity of forests at the local scale by using existing research infrastructure for measurement of carbon fluxes (EC monitoring system), freely available high temporal resolution data from remote sensing (MODIS) and state of the art process model (Biome-BGC). The proposed research will provide the first evaluation on the quality of MODIS GPP and NPP estimates for Central-European lowland forests. Field measurement campaigns combined with state of the art digital photogrammetry will be performed to parameterise Biome-BGC model, and validate data from MODIS and model simulations. Using available data on future climate scenarion, productivity of oak forests for the future 30-50 years will be simulated with Biome-BGC model.   The proposed research is in line with the objectives of the EU Forest Action Plan which, among others proposes to encourage adaptation to the effects of climate change (key action 6), and to work toward a European Forest Monitoring System (key action 8).]]></summary_en></project><project>
<id>2634</id><title_hr><![CDATA[Održivi optički komunikacijski i senzorski sustavi zasnovani na rezonatoru s produženom rezonantnom šupljinom]]></title_hr><title_en><![CDATA[]]></title_en><user_id>7148</user_id><user_firstLast_name>Dubravko Babic</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2014-06</proposal_call><code>DOK-2014-06-7862</code><acronim><![CDATA[EXCAR]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Elektrotehnika, </scie_field_hr><scie_field_en>Electrical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id>19032</team_members_id><team_members_names><![CDATA[ Doktorand: Marko Šprem ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[optical access networks, WDM-PON, optical sensors, colorless optical transmitter, extended cavity, optical noise, noise reduction, wavelength re-use]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[The objective of this project is to advance the state-of-the-art in optical access networks and also apply the same ideas to sensor networks. Proposed project addresses the EU targets as defined by European Commission’s “Europe 2020” strategy for smart growth by focusing on research and development of highly-integrated and energy efficient optical transceivers and wavelength-division-multiplexing (WDM) components for next-generation of access and mobile backhaul networks using passive optical network (PON) infrastructure. The primary challenge, in wider adoption of WDM-PON, lies in the development of sufficiently low cost technology to be used at the users’ premises. Self-seeded WDM-PON has been actively investigated in recent years as potentially the lowest cost solution for next-generation access networks. The primary attraction of this architecture is its simplicity, lower power consumption, and cost advantage. Similar principles can be applied to multiplexing and interrogation systems for optical sensors and our aim is to develop, analyze and demonstrate sustainable all-optical infrastructure based on extended cavity resonators able to provide physical layer for both, access communication and sensor networks.At University of Zagreb we invented an optical component, the modulation-averaging reflector, which reduces the penalty due to modulation of the seeding light and depolarizes the light oscillating in the cavity thereby stabilizing the extended resonator. This was the first step towards a future-proof optical access technology. Within this project we will fully develop and characterize systems based on extended cavity resonators with modulation averaging reflectors. We will also explore the use of modulation averaging concept in a novel communication optical source architecture based on wavelength re-use. Finally, the concept of extended cavity resonators will also be implemented in non-communication applications such as new optical sensor schemes.]]></summary_en></project><project>
<id>2635</id><title_hr><![CDATA[Upravljanje prostorno distribuiranim dinamičkim sustavima]]></title_hr><title_en><![CDATA[]]></title_en><user_id>7315</user_id><user_firstLast_name>Andrej Jokić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2014-06</proposal_call><code>DOK-2014-06-7947</code><acronim><![CDATA[ConDis]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Strojarstvo, </scie_field_hr><scie_field_en>Mechnical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet strojarstva i brodogradnje]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Mechanical Engineering and Naval Architecture]]></institution_en><team_members_id>17859</team_members_id><team_members_names><![CDATA[ Doktorand: Mihael Lobrović ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[control systems, distributed control, optimization, large-scale systems, vibrations]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Following impressive developments in communication and information technologies, but also in sensor and actuator technologies, a whole set of novel products and systems has emerged, which only recently seemed unfeasible. Examples of such systems include the so-called smart structures composed of a large number of sensors and actuators mounted on constructive elements (beams/plates) with the goal to damp undesired vibrations or to control flow of fluids; adaptive optics with large amount of optical elements; smart electrical power systems; highways with automated cars driving in platoons. Common characteristic of all of the above mentioned systems is that they are composed of a large number of spatially distributed dynamical subsystems which operate under constant mutual interactions through some physical interconnections (network) and/or communication links (network). Today, it is widely acknowledged that the key challenge in development of such dynamical networks is synthesis of algorithms for their control. The main goal of this project is development of some of the key elements in fundamental theory of control for spatially distributed systems, together with constructive controller synthesis algorithms suitable for application in real-life problems. The research focus will be on distributed control solutions in which each dynamical system in the network is controlled by its local controller and each local controller communicates and coordinates its actions with a (usually small) set of directly neighboring controllers. Our approach will be based on innovative elements from the theory of dissipative systems, while both spatially invariant networks and generic dynamical networks with arbitrary interconnection graph will be considered. The developed control algorithms will be verified in laboratory experiments on groups of mobile robots and on a distributed vibration control platform.]]></summary_en></project><project>
<id>2636</id><title_hr><![CDATA[Općeslavenski lingvistički atlas (OLA) i Europski lingvistički atlas (ALE)]]></title_hr><title_en><![CDATA[]]></title_en><user_id>3723</user_id><user_firstLast_name>Dunja Brozović Rončević</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2014-06</proposal_call><code>DOK-2014-06-4255</code><acronim><![CDATA[OLAALE]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Filologija, </scie_field_hr><scie_field_en>Philology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zadru]]></institution_hr><institution_en><![CDATA[University of Zadar]]></institution_en><team_members_id>17864</team_members_id><team_members_names><![CDATA[ Doktorand: Ivana  Gmižić ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[dialectology, linguistic atlas, linguistic maps, slavic languages, european languages]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[The “General Slavic Linguistic Atlas” (OLA) and the “European Linguistic Atlas” (ALE) are long-term international linguistic projects. The OLA project involved research material derived from a special survey carried out in 853 settlements, the result of which was an extremely rich dialectological registry. The material collected does not confirm the traditional view of the disintegration of the Proto-Slavic language, instead showing that the disintegration process of the Slavic whole was much more complex. This is seen in isoglosses that cut Slavic territory into the most highly differing directions. This is proof that particular Slavic groups in various historical periods found themselves in complex relationships amongst themselves and that were constantly changing for economic, political, or cultural reasons. Linguistic material for ALE was collected using a special survey carried out in a majority of European countries, including 15 Croatian survey points. The project also involves the etymological and onomasiological interpretation of linguistic material from all European survey points.This project of linguistic atlases provides world dialectology with organised data on the phonetic, phonological, morphological and lexical systems of a large number of languages and dialects, and enables the well-founded study of the linguistic development of European languages. Croatian material is presented and interpreted, and the linguistic relationships between data from the dialects researched is confirmed. Conclusions are drawn on the history and development of languages, on the relationships between them, and thus on the relationships of the Croatian language towards neighbouring and distant dialects. This will provide material for comparative genetic and typological research of linguistic systems in the Slavic and non-Slavic world. These synchronic and diachronic relationships will be presented in the OLA and ALE books and atlases in the form of maps and commentary.]]></summary_en></project><project>
<id>2641</id><title_hr><![CDATA[Napredni elektromotorni pogoni za primjene u vuči]]></title_hr><title_en><![CDATA[]]></title_en><user_id>3873</user_id><user_firstLast_name>Damir Žarko</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2014-06</proposal_call><code>DOK-2014-06-2238</code><acronim><![CDATA[ELTRAC]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Elektrotehnika, </scie_field_hr><scie_field_en>Electrical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id>17824</team_members_id><team_members_names><![CDATA[ Doktorand: Tino Jerčić ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[electric traction, electric drives, energy efficiency, optimization, life cycle cost, control of electric drives, power electronics, electric machines]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[The development of more efficient transport equipment and reduction of their environmental footprint is in the scope of the energy policy of the EU. The electrification of the transport equipment and the shift of the freight shipments from road to more efficient rail are some of the key elements for the overall increase of energy efficiency in transport and reduction of the greenhouse gas emissions. This project puts emphasis on development of advanced electric drives for traction vehicles for passenger and freight transport running on tracks. Traditional approach to the design of electric drives has an emphasis on components without insufficient insight into the interaction among them and thus it fails to deliver the optimal performance of the overall traction system. The main objective of this project is to enhance the general approach to design of electric drive systems for traction applications by utilizing a synergetic approach to component design accompanied with advanced control algorithms to maximize the system performance and efficiency and minimize the life cycle cost of the vehicle. This objective will be achieved through: (i) development of software tools for computer aided design of electric drive components for traction applications using multiphysics approach with consideration of component interaction with the rest of the system, (ii) development of different traction power converters topologies for evaluation of various modulation and control methods, (iii) development of software environment for dynamic simulation of traction system performance which couples complex nonlinear models of system components with the models of control algorithm and vehicle dynamics, (iv) development of the electric drive control system based on optimal control approach which ensures maximum efficiency of the system during entire drive cycle of the vehicle. The developed algorithms will be experimentally tested on the scaled model of the traction system.]]></summary_en></project><project>
<id>2642</id><title_hr><![CDATA[Animal and robot Societies Self-organise and Integrate by Social Interaction - ASSISI_bf]]></title_hr><title_en><![CDATA[]]></title_en><user_id>5244</user_id><user_firstLast_name>Stjepan Bogdan</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2014-06</proposal_call><code>DOK-2014-06-3174</code><acronim><![CDATA[]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Elektrotehnika, </scie_field_hr><scie_field_en>Electrical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id>17856</team_members_id><team_members_names><![CDATA[ Doktorand: Tomislav Haus ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>2643</id><title_hr><![CDATA[Višeagentno modeliranje velikih razmjera za MMORPG mrežne igre ]]></title_hr><title_en><![CDATA[]]></title_en><user_id>891</user_id><user_firstLast_name>Markus Schatten</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2014-06</proposal_call><code>DOK-2014-06-1015</code><acronim><![CDATA[ModelMMORPG]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Informacijske znanosti, </scie_field_hr><scie_field_en>Information sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet organizacije i informatike]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Organization and Informatics]]></institution_en><team_members_id>17828</team_members_id><team_members_names><![CDATA[ Doktorand: Bogdan Okreša Đurić ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[large-scale multi-agent systems, agent based modeling, mmorpg, organizational methods, organizational design, artificial intelligence]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Massively multi-player on-line role playing games (MMORPGs) give us the opportunity to study two important aspects of computing: (1) large-scale virtual social interaction of people (players) and (2) the design, development and coordination of large-scale distributed artificial inteligence (AI). A common denominator for both aspects are the methods used to study them: social interaction can be descibed and simulated using agent-based models (ABM social science perspective) whilst distributed AI is commonly modelled in terms of multi-agent systems (MAS computer science perspective). The important question to ask in both perspectives is how do agents organize in order to perform their tasks and reach their objectives? Herein we will employ a combined empirical and theoretical approach towards finding the answer to this question.From the empirical side, we shall study the human behaviour on a number of venues across various gaming servers in order to find most suitable structures, cultures, processes, strategies and dynamics employed by most successful player communities.  From the theoretical side, we shall test a multitude of organizational architectures from organization theory in various MMORPG settings, and compare them with methods found in empirical research.Our research is therefore aimed towards enriching the organizational design methods for the development of MMORPG to foster the development of self-organizing and adaptable networks of large-scale multi-agent systems.With this in mind, our main goals are:1) To identify and formalize adequate organizational design methods for developing LSMAS in MMORPGs.2) To couple them with real-life and future scenarios from industry.3) To provide open and accessible tools, which will allow for design, development, implementation, control, simulation and maintenance of LSMAS in MMORPG.]]></summary_en></project><project>
<id>2644</id><title_hr><![CDATA[Defolijatori kao invazivni šumski štetnici u uvjetima klimatskih promjena ]]></title_hr><title_en><![CDATA[]]></title_en><user_id>3209</user_id><user_firstLast_name>Milan Pernek</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2014-06</proposal_call><code>DOK-2014-06-9789</code><acronim><![CDATA[DIFPEST]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Biotehnologija, </scie_field_hr><scie_field_en>Biotechnology, </scie_field_en><institution_hr><![CDATA[Hrvatski šumarski institut]]></institution_hr><institution_en><![CDATA[Croatian Forest Research Institute]]></institution_en><team_members_id>17805</team_members_id><team_members_names><![CDATA[ Doktorand: Ivan Lukić ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[invasive forest pests, climate change, biodiversity, insect pathology, Lymantria dispar, Abraxas pantaria,Cydalima perspectalis]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Climate change, particularly extreme weather events, can directly affect forest pests and the damage they cause by influencing the pests’ development, survival, reproduction and spread and by altering host defences and susceptibility. Basic knowledge of the identity, origin, pathway, and time of introduction of invasive species is essential for assessing the threats. Warming is expected to force species to shift their distributions by expanding into new climatic areas. Several projects have shown that genotypes have increasingly migrated to the north in the last decade, mainly caused by climate change. Records of changes as a result of pest-host-climate change interaction, including possible reasons for changes, are a crucial point of forest monitoring which forms the basis for control strategies and forest management decisions. We will build case studies to represent a specific pest-host-climate change interaction model: native and potentially invasive: i) from one isolated population to other population, (Gypsy Moth); ii) from one climate/geographic region to another (Abraxas pantaria) and non-native potentially invasive in a new climate/geographic region (Cydalima perspectalis). The study presents an extensive research on targeted insect pests in Croatia, taking into account the biology of the pest and host plants and all aspects of the bioecology of the species like genetic constitution and origin, thermal requirements, possible host plants, palatability, influence of antagonists etc.) that influence its spread in a novel environment influenced by climate change and possible serious damage. All the gained data could be used for predictive pest risk analysis models for the researched species, as well as for other native and non-native invasive species that could become a serious threat to Croatian forest ecosystems in changed climate conditions in the near future. ]]></summary_en></project><project>
<id>2645</id><title_hr><![CDATA[Aktivacijski receptori NK-stanica specifični za virus i njihovo izbjegavanje od strane virusa]]></title_hr><title_en><![CDATA[]]></title_en><user_id>4958</user_id><user_firstLast_name>Astrid Krmpotić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2014-06</proposal_call><code>DOK-2014-06-6481</code><acronim><![CDATA[ViSpeNKRec]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Medicine]]></institution_en><team_members_id>17754</team_members_id><team_members_names><![CDATA[ Doktorand: Jelena Železnjak ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[NK cells, cytomegalovirus, immunoevasion, Ly49 receptors, KIR receptors, transcriptomics]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[The infection of mice with mouse cytomegalovirus (MCMV) as a model of human CMV (HCMV) infection has been particularly informative in elucidating the role of antiviral immune response. NK cells are essential in early control of CMV infection. An evolutionary struggle between NK cells and CMVs can be inferred from a numerous viral mechanisms designed to compromise NK cell function. A deeper insight was gained by studying MCMV evasion of ‘missing-self’ mechanisms and host response to this immunoevasion, illustrated by several MCMV-specific NK cell activating receptors. The work on Ly49H receptor emphasized the selective pressure imposed on the virus to generate variants no longer recognized by this receptor. Another example can be seen from the function of viral m04 protein, which binds to newly synthesized MHC-I molecules and escorts them to the cell surface to engage inhibitory Ly49 receptors. However, while m04 prevents NK cell activation by escaping ‘missing-self’ recognition, several activating Ly49 receptors also depend on its presence for their own recognition of infected cells. Beside m04, another so far unidentified viral factor is required for turning on the activating Ly49 receptors. In addition to characterization of this new viral gene, the aim of this study is to elucidate the functional significance of MCMV-specific activating Ly49 receptors and their interaction with inhibitory counterparts during primary and latent infection.Ly49 receptors in mice are functional homologues of KIR receptors in humans. Recent studies also indicate a strong impact of HCMV on the repertoire and frequency of activating KIR-expressing NK cells, suggesting their specific response to this virus. Therefore, in addition to the MCMV genes involved in ligation of activating Ly49 receptors, here we also propose study aimed to characterize HCMV gene(s) involved in ligation of activating KIRs. We expect these studies to provide new data of groundbreaking potential in the field.]]></summary_en></project><project>
<id>2646</id><title_hr><![CDATA[Music migration in the early modern age: The meeting of the European East, West and South]]></title_hr><title_en><![CDATA[]]></title_en><user_id>7808</user_id><user_firstLast_name>Vjera Katalinić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2014-06</proposal_call><code>DOK-2014-06-5703</code><acronim><![CDATA[]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Znanost o umjetnosti, </scie_field_hr><scie_field_en>Arts, </scie_field_en><institution_hr><![CDATA[Hrvatska akademija znanosti i umjetnosti]]></institution_hr><institution_en><![CDATA[Croatian Academy of Sciences and Arts]]></institution_en><team_members_id>17763</team_members_id><team_members_names><![CDATA[ Doktorand: Maja Milošević ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>2647</id><title_hr><![CDATA[Razvoj i upotreba modela za procjenu potencijala za rast za mala i srednja poduzeća u Hrvatskoj]]></title_hr><title_en><![CDATA[]]></title_en><user_id>2825</user_id><user_firstLast_name>Nataša Šarlija</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2014-06</proposal_call><code>DOK-2014-06-6152</code><acronim><![CDATA[CROSMEGROWTH]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Ekonomija, </scie_field_hr><scie_field_en>Economy, </scie_field_en><institution_hr><![CDATA[Sveučilište Josipa Jurja Strossmayera u Osijeku, Ekonomski fakultet u Osijeku]]></institution_hr><institution_en><![CDATA[Josip Juraj Strossmayer University of Osijek, Faculty of Economics]]></institution_en><team_members_id>17875</team_members_id><team_members_names><![CDATA[ Doktorand: Ana Bilandžić ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[prediction of growth potential, high-growth SMEs, creative industry, policy recommendation for high growth SMEs, access to finance for high-growth SME]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[The importance of high-growth enterprises for job creation has been widely substantiated by economic research in recent years. The number and share of high-growth enterprises is relatively small, but the number and share of jobs they create is disproportionally large. The small and medium enterprises with the potential of growth are in the focus of this project. Two overarching goals of this project are:1.	Development of growth potential prediction models for SMEs in CroatiaThe main activities leading up to this goal are: (i) to analyse previous studies relevant for the topic of SMEs&#39; growth potential; (ii) to develop growth potential prediction models for SMEs in Croatia; (iii) to make the models for assessing growth potential available to SMEs to use for purposes of assessing and improving their businesses; (iv) to compare differences in growth potential among SMEs from main industries; (v) to analyse growth potential of SMEs within creative industries and within manufacturing industries.  2.	Providing recommendations to policy makers, recommendation for development of educational programs for SME owners and managers, and recommendations related to sources of finance available to SMEsBased on the research results and models created as part of this project, the main recommendations related to growth potential of SMEs will cover areas of: (i) policy making; (ii) education; and (iii) sources of finance. In recent years policy makers have shown increased interest in fostering fast growing enterprises as they are seen as a key driver of economic growth and employment. Studies conducted in listed companies have showed that two key aspects in supporting high-growth companies are education and access to finance. To allow for comparison of other countries with Croatia, results of this project will be published in relevant scientific journals. To help boost Croatian economy, the results will be presented to all stakeholders interested in this topic.]]></summary_en></project><project>
<id>2648</id><title_hr><![CDATA[Metakognicija kod kategorijalnog učenja, mišljenja i razumijevanja]]></title_hr><title_en><![CDATA[]]></title_en><user_id>4615</user_id><user_firstLast_name>Dražen Domijan</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2014-06</proposal_call><code>DOK-2014-06-2246</code><acronim><![CDATA[METCALTHIC]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Psihologija, </scie_field_hr><scie_field_en>Psychology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Filozofski fakultet u Rijeci]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Humanities and Social Sciences]]></institution_en><team_members_id>6968</team_members_id><team_members_names><![CDATA[ Doktorand: Tanja Gulan ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[metacognition, monitoring, dual processes, category learning, thinking, comprehension]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[The fundamental problem of education is how to create a learning environment which will facilitate the acquisition of knowledge and skills. Psychology of education attempts to identify mental processes and mechanisms underlying our ability to learn. Research on self-regulated learning and metacognition is a topic of special importance for educational psychology. Self-regulated learning encompasses cognitive, motivational and behavioral processes which occur while learners undertake activities to accomplish a learning goal. Self-regulation is based on a cyclical process of monitoring and control. The learner monitors the efficiency of the applied learning strategies and responds to feedback obtained from the monitoring process. Metacognition is studied intensively in the areas of memory and text comprehension. The central aim of the project is to explore metacognitive processes of monitoring and control in the domains of: 1. Category learning, 2. Thinking, 3. Grounded (situated) comprehension. All of these domains have been studied extensively but in isolation from metacognition. Our goal is to bring together these disparate fields of study under the same research program. Unifying theme of the project is the distinction between Type 1 and Type 2 processes which can be identified in each domain and whose properties will guide metacognitive judgments. Project team consists of 5 established researchers in the field of experimental psychology and 5 doctoral students whose PhD theses are closely related to the project aims. The project team will utilize newly established Laboratory for experimental psychology equipped with facilities necessary to carry out the proposed project. The project will answer the important question of how accurate are the metacognitive judgments and how effective are the processes of monitoring and regulation in the cognitive domains where metacognition has not been studied in greater detail.]]></summary_en></project><project>
<id>2649</id><title_hr><![CDATA[Social PracticE Cultural Trauma and REestablishing Solid Sovereignties - &#39;&#39;SPECTRESS“ (FP7 - Grant Agreement No. PIRSES-GA-2013-612654)]]></title_hr><title_en><![CDATA[]]></title_en><user_id>5748</user_id><user_firstLast_name>Nebojša Blanuša</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2014-06</proposal_call><code>DOK-2014-06-6078</code><acronim><![CDATA[]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Politologija, </scie_field_hr><scie_field_en>Political Science, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet političkih znanosti]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Political Science]]></institution_en><team_members_id>17769</team_members_id><team_members_names><![CDATA[ Doktorand: Kosta Bovan ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>2650</id><title_hr><![CDATA[Biobanking and Biomolecular Resources Research Infrastructure - Large prospective cohorts]]></title_hr><title_en><![CDATA[]]></title_en><user_id>4228</user_id><user_firstLast_name>Ozren Polašek</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2014-06</proposal_call><code>DOK-2014-06-8445</code><acronim><![CDATA[]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Javno zdravstvo i zdravstvena zaštita, </scie_field_hr><scie_field_en>Public health and health services, </scie_field_en><institution_hr><![CDATA[Sveučilište u Splitu, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Split School of Medicine]]></institution_en><team_members_id>17833</team_members_id><team_members_names><![CDATA[ Doktorand: Andrea Gelemanović ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>2652</id><title_hr><![CDATA[Proteomski pristup otkrivanju biomarkera ranog oštećenja bubrega i srca u pasa]]></title_hr><title_en><![CDATA[]]></title_en><user_id>801</user_id><user_firstLast_name>Vladimir Mrljak</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2014-06</proposal_call><code>DOK-2014-06-5716</code><acronim><![CDATA[BioDog]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Veterinarska medicina, </scie_field_hr><scie_field_en>Veterinary medicine, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Veterinarski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Veterinary Medicine]]></institution_en><team_members_id>17792</team_members_id><team_members_names><![CDATA[ Doktorand: Petra Nižić ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[biomarkers, dog, proteomics, kidney, heart, babesiosis, idiopathic dilated cardiomyopathy, chronic valvular disease]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Proteins play essential roles in every cellular process. Biomarkers have the potential to identify key disease indicators at the individualised level, as well as to detect a disease at the early-stages before the development/advance of a serious illness. The emergence of innovative, post-genomic technology, like proteomics, led to the development of strategies aimed at identifying altered, sensitive biomarkers specific to the disease among thousands of molecules present in biological samples. Blood and urine contains multitude, unstudied, and unknown biomarkers, particularly in low-molecular region of blood and urine proteome. Babesiosis, idiopathic dilated cardiomyopathy (iDCM), and chronic valvular disease (CVD-MV) in dogs are common and serious disease. The aims of the project is: to discover novel, early-stage biomarkers of kidney and cardiac disease in dogs which could lead toward more precise and adequate diagnose, prognosis, and monitoring of these diseases; to perform a proteomic analysis on the sera and urine of dogs with uncomplicated and complicated form of babesiosis, as well as dogs with diagnosed iDCM and CVD-MV in order to identify novel, early-stage diagnostic and prognostic biomarkers; to expand the pathway signalling research in order to improve the understanding of pathogenesis for studied disease; to validate new biomarkers for studied diseases.  Tthese expected scientific outcomes will contribute in practice: (a) in a short term view, to detect individualised molecular fingerprints; to improve the diagnosis and prognosis of iDCM, CVD-MV, and babesiosis, as well as potential targets for novel approaches to monitor the therapies of these diseases; to enable the ability to personalise the treatment of individual patients resulting in enhanced patient care; and (b) in a long-term view, to allow entry of proteomics in clinical veterinary medicine in Croatia and transfer of knowledge in –omics- technologies in other parts of veterinary medicine.]]></summary_en></project><project>
<id>2654</id><title_hr><![CDATA[Mehanizam djelovanja gvanilinskih peptida u mozgu]]></title_hr><title_en><![CDATA[]]></title_en><user_id>5255</user_id><user_firstLast_name>Aleksandra Sinđić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2014-06</proposal_call><code>DOK-2014-06-3023</code><acronim><![CDATA[]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb School of Medicine]]></institution_en><team_members_id>12975</team_members_id><team_members_names><![CDATA[ Doktorand: Nikola Habek ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>2655</id><title_hr><![CDATA[Primjena vakuumskog hlađenja u proizvodnji hrane produljene trajnosti i svježine]]></title_hr><title_en><![CDATA[]]></title_en><user_id>11173</user_id><user_firstLast_name>Mirjana Hruškar</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2014-06</proposal_call><code>DOK-2014-06-1031</code><acronim><![CDATA[]]></acronim><duration></duration><status>Prekinut</status><financ_value></financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Prehrambena tehnologija, </scie_field_hr><scie_field_en>Food technology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prehrambeno-biotehnološki fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Food Technology and Biotechnology]]></institution_en><team_members_id>19135</team_members_id><team_members_names><![CDATA[ Doktorand: Saša Ajredini ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>2656</id><title_hr><![CDATA[Biofizikalni dizajn antimikrobnih peptida i inovativni molekularni deskriptori]]></title_hr><title_en><![CDATA[]]></title_en><user_id>19875</user_id><user_firstLast_name>Jasna Puizina</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2014-06</proposal_call><code>DOK-2014-06-8371</code><acronim><![CDATA[BioAmpMode]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, </scie_field_hr><scie_field_en>Physics, </scie_field_en><institution_hr><![CDATA[Sveučilište u Splitu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Split, Faculty of Science]]></institution_en><team_members_id>17844</team_members_id><team_members_names><![CDATA[ Doktorand: Tomislav Rončević ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[Antimicrobial peptides, Molecular descriptors, Therapeutic index, Drug development, Design, Data-mining, Antibiotics, Multidrug resistance]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[The starting point of this interdisciplinary project is bioinformatic and chemoinformatic data collection connecting molecular structure with physico-chemical and biological properties. In the case of antimicrobial peptides, measured biological activity and therapeutic index data will be collected from published papers with the goal of constructing robust and accurate predictive models. A large amount of data regarding the 20 natural amino acids attributes will also be collected and analysed. We plan to propose new scales of amino-acid attributes that may be a basis for a multitude of future studies. In our experience, construction of good predictive models is not possible without using biophysical insights to propose appropriate molecular descriptors crucial for data-mining procedure and model building. These models should be based on newly developed molecular descriptors. Study of molecular descriptors will be important part of this project, their extremal properties (as indicators of the most active compounds), their complexity of calculation (since exhaustive search for optimal compounds can be computationally demanding) and their interrelationships. Dedicated algorithms for in-silico identification or proposal of structures with the desired properties will be built and verified through synthesis, characterization and testing of predicted antimicrobials. The activity, selectivity, conformation and mechanism of action of lead compounds will be explored using biophysical, biochemical and microbiological techniques. Preliminary investigations by our group of graduate, doctoral and postdoctoral biophysics students has already led to the identification of two designed peptides as being very active against pan-resistant Acetinobacter baumanni, so that initial drug development is within the scope of this project with the aim of finding new classes of non-toxic peptide antibiotics active against multidrug resistant bacteria.]]></summary_en></project><project>
<id>2657</id><title_hr><![CDATA[Razvitak transkriptoma specifičnih populacija neurona u kortikalnim područjima ljudskog mozga bitnim za jezik i sustav zrcalnih neurona]]></title_hr><title_en><![CDATA[]]></title_en><user_id>7740</user_id><user_firstLast_name>Miloš Judaš</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2014-06</proposal_call><code>DOK-2014-06-3663</code><acronim><![CDATA[]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb School of Medicine]]></institution_en><team_members_id>17841</team_members_id><team_members_names><![CDATA[ Doktorand: Andrija Štajduhar ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>2658</id><title_hr><![CDATA[Višeskalni model betona s identifikacijom parametara]]></title_hr><title_en><![CDATA[]]></title_en><user_id>4072</user_id><user_firstLast_name>Ivica Kožar</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2014-06</proposal_call><code>DOK-2014-06-5984</code><acronim><![CDATA[ConcreteMuScID]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Građevinarstvo, </scie_field_hr><scie_field_en>Civil engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Građevinski fakultet u Rijeci]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Civil Engineering]]></institution_en><team_members_id>17853</team_members_id><team_members_names><![CDATA[ Doktorand: Tea Rukavina ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[multi-scale, concrete, system identification, dynamic loading, computer model]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[In complex numerical models the calibration can only be achieved through interaction of measured data with the underlying mathematical model. Especially difficult situation occurs when loading is stochastic (e.g. wind, earthquake, traffic) since there is no direct relation between loading (input) and displacements (output).	System parameter identification will be based on inverse mathematical formulation so to present a reliable and theoretically sound procedure for identification of required parameters. One of the main goals of the system identification procedure is representative volume identification. It will be necessary to consider non-Gaussian stochastic processes with heavy tails characterizing dangerous rare events.	Regarding material parameters this project advocates the hypothesis that the fracture energy of a material is approximately constant and that the material constitutive law should not incorporate “rate effect”. The idea of (approximately) constant fracture energy for all loading rates is new and important in models of concrete under the dynamic loading. Also, the inclusion of the viscous parameter in the existing 3D microplane model for concrete is of vital importance for fatigue analysis since it connects creep and shrinkage (internal material loading) with dynamic loading (external structural loading).	In the end the developed concrete model will account for corrosion by coupling the mechanical properties of concrete and properties affecting the transport of humidity, oxygen and  chloride (chemo-hygro-thermo-mechanical model).	The calibration of the 3D model and its verification will be performed based on the simulation of the corresponding experimental tests from the laboratory and the available literature according to the procedure for system parameter identification described above.	Two main characteristics of the project: highly applicative and at the same time capable of producing high impact scientific results.]]></summary_en></project><project>
<id>2662</id><title_hr><![CDATA[Projekt HRZZ-Uloga ribosomskih proteina L5 i L11 u aktivaciji tumor supresora p53 i patogenezi zloćudnih tumora]]></title_hr><title_en><![CDATA[]]></title_en><user_id>7705</user_id><user_firstLast_name>Siniša Volarević</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2014-06</proposal_call><code>DOK-2014-06-3128</code><acronim><![CDATA[]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Medicine]]></institution_en><team_members_id>17834</team_members_id><team_members_names><![CDATA[ Doktorand: Deana Jurada ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>2663</id><title_hr><![CDATA[Procjena ponašanja konstrukcija u graničnim uvjetima rada]]></title_hr><title_en><![CDATA[]]></title_en><user_id>3309</user_id><user_firstLast_name>Goran Turkalj</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2014-06</proposal_call><code>DOK-2014-06-9526</code><acronim><![CDATA[STRUBECON]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Temeljne tehničke znanosti, </scie_field_hr><scie_field_en>Basic engineering sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Tehnički fakultet]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Engineering]]></institution_en><team_members_id>17760</team_members_id><team_members_names><![CDATA[ Doktorand: Damjan Banić ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[structures, material properties, experimental investigations, numerical investigations, limit state, assessment of structural behaviour]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Structures are designed according to their purpose taking into account all relevant service life requirements, which are usually related to a factor of safety, material properties, service life conditions and of course service life prediction. Structure may be sometimes exposed to unexpected conditions, let say adverse or hazard conditions. These conditions may cause failures making structure incapable to perform the function for which it has been designed. The task is to make an assessment of the structure behaviour at mentioned conditions and decide if the structure is capable for further operation. This means the assessment should provide an answer if the structure has sustained irreparable damage. Therefore, the main objective is to provide an assessment of structure behaviour, by comparing of the parameters like stress, strain, crack occurring, etc., caused by certain load level and temperature at this unexpected limit state with those allowed by material properties. To assess structural behaviour in operation at limit state, the following research sub-objectives should be accomplished: testing of material properties for the different environmental conditions; definition of impact energy as well as the determination of the crack driving force and life assessment of structural elements; evaluation of the semi-rigid structural joints/connections behaviour; development of a numerical algorithm for optimization of semi-rigid framed structures; creep buckling simulations of composite beam-type structures; proper constitutive modelling at limit operating conditions (i.e. plasticity, damage, thermomechanical coupling); application of new materials to be used at limit state – nanocomposites. Targeted structures are single and multi storey steel buildings, rigs, high-power electrical transmission towers, ship structures, etc.]]></summary_en></project><project>
<id>2665</id><title_hr><![CDATA[Bioindikatori vodenih masa u Jadranu]]></title_hr><title_en><![CDATA[]]></title_en><user_id>2829</user_id><user_firstLast_name>Zrinka Ljubešić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2014-06</proposal_call><code>DOK-2014-06-5886</code><acronim><![CDATA[BIOTA]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Biologija, </scie_field_hr><scie_field_en>Biology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>17842</team_members_id><team_members_names><![CDATA[ Doktorand: Maja Mejdandžić ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[Adriatic Sea, climate changes, water mass tracers, cyanobacteria, coccolithophorids]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Interannual changes in the circulation patterns and water mass dynamics highly influence biogeochemical processes in the Adriatic Sea, consequently impacting the functioning of the Adriatic ecosystem. Specific phytoplankton ecological preferences drive their temporal and spatial distribution, reflecting their dependence on specific temperature ranges, light levels, nutrient availability and other environmental gradients. Hence, some phytoplankton taxa can be used as water mass tracers (biotracers). We hypothesize that picophytoplanktonic prokaryote Prochlorococcus and nanophytoplanktonic eukaryotes coccolithophores: Emiliania huxleyi and/or Gephyrocapsa oceanic are such organisms, and can be used for tracing water masses in the Adriatic. Here, we propose interdisciplinary study where oceanography, taxonomy of phytoplankton and molecular recognition are combined to detect and follow water masses. Two winter cruises in the southern Adriatic will be conducted with station positions and sampling depths defined in situ. Water mass detection will be based on pre-defined physical characteristics; however, we also plan to use optical measurements in conjunction with the proposed sampling to develop an optical based criterion for definition of the targeted water masses. Phytoplankton community will be assessed using multiple tools to confirm the presence and to determine distribution, abundance and diversity of the proposed biotracers in sampled water masses. With the variability and trends of the Adriatic circulation as well as the water mass characteristics brought on by changing climate, we believe that proposed study is timely and needed as it is offering a holistic and integrated approach to oceanography of the Adriatic. Most importantly, this study is proposing to develop a new set of interdisciplinary tools that will be essential for future research activities.]]></summary_en></project><project>
<id>2666</id><title_hr><![CDATA[MAtematička analiza multifizikalnih problema koji uključuju tanke i kompozitne strukture i fluide]]></title_hr><title_en><![CDATA[]]></title_en><user_id>5074</user_id><user_firstLast_name>Boris Muha</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2014-06</proposal_call><code>DOK-2014-06-4384</code><acronim><![CDATA[MAMPITCoStruFl]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Matematika, </scie_field_hr><scie_field_en>Mathematics, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>17761</team_members_id><team_members_names><![CDATA[ Doktorand: Marija Galić ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[thin structures, composite structures, dimensional reduction, homogenization, Gamma convergence, fluid-structure interaction, existence of solution ]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Composite materials are materials made from two or more constituent materials with different physical properties that, when combined, produce a material with characteristics different from those of its individual components. Thin and composite structures are of extreme importance for applications in engineering (e.g. building blocks, boats, ships, aircraft design) and biology (bones, biological tissues, blood vessels) where they are often subjected to fluid load. The analysis of these kind of complex multi-physics systems is very challenging from the mathematical point of view. Namely, the analysis of thin and composite structures and fluids includes the analysis of nonlinear partial differential equations (nonlinear PDEs), which leads to interesting mathematical questions (Gamma limits of a certain system of nonlinear equations with highly oscillating coefficients, existence for a certain system of nonlinear PDEs). This project plans the following: derivation of lower dimensional models in elasticity for highly oscillating materials, optimal design problems, derivation and analysis of fluid-structure interaction problems (derivation of coupling conditions, well-posedness and asymptotic stability analysis). We will use both Calculus of Variation and PDEs techniques to approach different topics, using the benefits from both. We strongly believe that this diversity will bring additional value to Croatian applied mathematics and will provide young people to develop and get acquainted with different approaches of the modern applied mathematics.]]></summary_en></project><project>
<id>2667</id><title_hr><![CDATA[Utjecaj okolišnog stresa na pojavnost i međudjelovanje biološki važnih organskih molekula i mikronutrijenata u morskom ekosustavu]]></title_hr><title_en><![CDATA[]]></title_en><user_id>81</user_id><user_firstLast_name>Blaženka Gašparović</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2014-06</proposal_call><code>DOK-2014-06-3224</code><acronim><![CDATA[AMBIOMERES]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, </scie_field_hr><scie_field_en>Chemistry, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>17849</team_members_id><team_members_names><![CDATA[ Doktorand: Tihana Sesar ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[organic matter, lipids, acidic polysaccharides, micronutrient metals, oligotrophy, eutrophy, monocultures, field work]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Recently documented oligotrophication of the Adriatic Sea caused by global changes opened questions how this reflects on the quality and quantity of organic matter (OM) produced by the phytoplankton and on the consequent influence on the micronutrient metals availability and cycling. Within the project, a progressive (model and in-situ) approach will be accomplished to reveal crucial alterations in the marine ecosystem. Initial investigations will imply model experiments on the interaction of selected OM (polysaccharides, lipids, polymeric organic matter containing N catalytic atoms) with micronutrient metals (Fe, Co, Cu, Zn and Cd). Additionally, phytoplankton monoculture incubation under various growth conditions (nutrient concentrations and temperature variations) will be included in order to comprehend multiple impacts on the phytoplankton OM production and micronutrients metals distribution. Model experiments will be followed by in-situ investigations at the selected oligotrophic and eutrophic areas of the Adriatic Sea. This will give holistic informations on the natural marine biochemical cycles and linkage between OM and micronutrient metals. In-situ investigations will be focused on the seasonal variations of the OM and micronutrient appearance and concentrations in combination with physico-chemical parameters (temperature, salinity, pH, O2), and dissolved and particulate organic carbon content, surface-active organic substances and macronutrients (PO4, NO3, NO2, NH4). These investigations will be assessed by intercomparable and multimethodological approaches using various chromatographic to electrochemical techniques. Finally, taking into account all obtained results an important part of the natural marine ecosystem processes will be characterized in the prospective of climate changes.]]></summary_en></project><project>
<id>2668</id><title_hr><![CDATA[Genetski mehanizmi lizosomalne disfunkcije u Parkinsonovoj bolesti]]></title_hr><title_en><![CDATA[]]></title_en><user_id>2684</user_id><user_firstLast_name>Fran Borovečki</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2014-06</proposal_call><code>DOK-2014-06-9688</code><acronim><![CDATA[LYSOGENE PD]]></acronim><duration></duration><status>Prekinut</status><financ_value></financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb School of Medicine]]></institution_en><team_members_id>19042</team_members_id><team_members_names><![CDATA[ Doktorand: Antonela Blažeković ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[Parkinson&#39;s Disease, alpha synuclein, next-generation sequencing, lysosomal dysfunction, iPSC]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Accumulation of misfolded proteins in the brain represents a pathological hallmark of neurodegenerative diseases, suggesting that inadequate clearance of aggregation-prone proteins plays an important role in the disease pathogenesis. The synucleinopathies, including Parkinson’s disease (PD) and dementia with Lewy bodies (LBD), are a group of neurodegenerative disorders characterized by the accumulation and aggregation of a-synuclein (aSyn). Studies on the rare inherited forms of PD caused by mutations in the aSyn gene have highlighted disturbed aSyn clearance through the autophagy-lysosomal pathway (ALP) as a key mechanism leading to PD/LBD. Furthermore, several rare inherited disorders caused by mutations in the lysosomal genes show parkinsonian-like phenotype and accumulation of aSyn, providing additional evidence for the role of lysosomal dysfunction in the pathogenesis of synucleinopathies. The goal of the project is to elucidate the involvement of lysosomal gene mutations and lysosomal dysfunction in the ethiology of PD/LBD. Using the next-generation sequencing and Haloplex-based protocol we will design LYSOGENE platform to anayze genetic mutations/variations in the ALP genes that may lead to and predispose to PD/LBD. The identified ALP mutations will be further characterized in vitro in human neuronal cell lines using the knockdown and overexpression approaches. In particular, we will monitor how the identified mutations affect ALP function, accumulation and aggregation of aSyn, as well as neurotoxicity. Finally, we will validate our mechanistic findings in a biologically relevant model of human dopaminergic neurons derived from the PD/LBD patient’s fibroblasts using the induced pluripotent stem cell technology. Through these studies we will identify genetic variations/mutations in the ALP genes that cause or contribute to PD/LBD. The results of the project may help to identify potential new therapeutic targets for development of neuroprotective treatments.]]></summary_en></project><project>
<id>2669</id><title_hr><![CDATA[Kodovi i s njima povezane kombinatoričke strukture]]></title_hr><title_en><![CDATA[]]></title_en><user_id>5935</user_id><user_firstLast_name>Vedran Krčadinac</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2014-06</proposal_call><code>DOK-2014-06-5387</code><acronim><![CDATA[CoCoS]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Matematika, </scie_field_hr><scie_field_en>Mathematics, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>17780</team_members_id><team_members_names><![CDATA[ Doktorand: Renata Vlahović ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[code, network coding, t-design, q-ary design, graph, strongly regular graph, finite group]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[The project will deal with construction of codes and combinatorial structures, such as combinatorial designs, designs over finite fields (q-ary designs), difference sets and various types of graphs, for example strongly regular graphs and divisible design graphs. Beside linear codes over finite fields and finite rings, we will also investigate quantum codes and network codes. In fact, the links and connections between codes and combinatorial structures are the main focus and emphasis of the proposed project. For constructions of the combinatorial structures and codes we will mainly use algebraic, geometric and enumerative techniques, as well as computational methods. When dealing with combinatorial structures, these include in particular constructions from finite groups and constructions using orbit matrices. The very general Kramer-Mesner method will be implemented and combined with other methods like that of tactical decompositions. Codes will be constructed directly from the obtained combinatorial structures, and vice versa. Our research in scope of this project will also include constructions of Hadamard matrices and related designs and codes. All gotten structures will be analyzed in terms of their automorphism groups and other structural (geometric, algebraic) properties. Obtained codes, designs and graphs will be compared with the previously known structures. As a result of the proposed research, we expect constructions of codes with good properties, possibly better than the presently known codes, and constructions and classifications of various combinatorial structures.]]></summary_en></project><project>
<id>2671</id><title_hr><![CDATA[Automorfne forme, reprezentacije i primjene]]></title_hr><title_en><![CDATA[]]></title_en><user_id>820</user_id><user_firstLast_name>Goran Muić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2014-06</proposal_call><code>DOK-2014-06-1470</code><acronim><![CDATA[Automorphic forms]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Matematika, </scie_field_hr><scie_field_en>Mathematics, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>17779</team_members_id><team_members_names><![CDATA[ Doktorand: Sonja Žunar ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[automorphic forms, representations, Eisenstein series, cuspidal forms, theta correspondence]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Recent and major breakthrough in the Langlands programme is a proof of existence endoscopic transfer of representations both local and global automorphic from split classical groups to GL(n) proved mainly by Arthur. Our research proposal  fits very well with this recent development. First of all, the work of Arthur has its local application in  the classification of representations of discrete series that was done by Moeglin and Tadić. Based on those results we plan to pursue the following investigations in the representation theory of p-adic groups.  We would like to compute the Jacquet modules of discrete series representations completely.This will help us understand representations parabolically induced from those discrete series (generalized principal series) completely. This will have consequence on the problems of determination of complementary series for classical groups a problem related to the classification of unitary representations. Results of Gan, Savin and Ichino will help us extend some of those results to metaplectic groups. This will have important consequence on the determination of theta correspondence for dual pairs consisting of odd orthogonal and metaplectic groups such as explicit determination of all theta lifts. In the theory of automorphic forms, we would like to understand the construction of Arthur and Moeglin more explicitly. This will construct new series of square integrable representations; some special cases were obtained earlier by Muić, and Muić and Hanzer.This will give locally many interesting unitary representations which are more complicated than that has appeared in earlier works of Speh, Rogawski, Tadić, Muić, Savin, and Hanzer. We will apply those methods to study cohomology and poles of automorphic L-functions. ]]></summary_en></project><project>
<id>2672</id><title_hr><![CDATA[Razvoj paketa računalskih programa za naprednu analizu štitova od gama i neutronskog zračenja]]></title_hr><title_en><![CDATA[]]></title_en><user_id>6070</user_id><user_firstLast_name>Krešimir Trontl</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2014-06</proposal_call><code>DOK-2014-06-6107</code><acronim><![CDATA[DOCPAGANSA]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Elektrotehnika, </scie_field_hr><scie_field_en>Electrical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id>17764</team_members_id><team_members_names><![CDATA[ Doktorand: Paulina Dučkić ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[machine learning, active learning, parallel and distributed computing, gamma shielding, neutron shielding]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Radiological safety analysis is equally important in all fields of peaceful application of nuclear energy, like industry or medicine, as well as for adequate radioactive waste management. In general, shielding analyses can be classified into two categories: preliminary analyses and final analyses. Preliminary analysis can be conducted using computer codes based on engineering methods, the most used one based on point-kernel method. Recent research indicated that a new approach can be used in determination of buildup factors as the key parameters of point-kernel method. The approach is based on machine learning technique, namely Support Vector Regression (SVR). For efficient training of the SVR models of a complex physical problem, an active learning procedure has to be defined. Final shielding analysis is usually conducted by computer codes based on either deterministic or statistic methods placing high time and hardware demands, but resulting in more accurate results. Advanced numerical procedures utilize advantages of both, deterministic approach as well as stochastic approach resulting in a hybrid deterministic-stochastic procedure increasing the efficiency of the overall analysis.The overall objective of the proposed project is the development of the synthesized calculational tool to enable all stages of a shield design to be performed within integrated environment. To accomplish this objective following activities are planned: definition of the optimal active learning procedure in regression framework to prepare data sets for SVR model creation, investigation of gamma and neutron buildup factors and preparation of SVR models, development of the computational tool for preliminary stage shielding design, optimization of hybrid deterministic-stochastic numerical procedure, development of the control module for automatic shielding analyses process control, preparation of front-end and back-end interface, testing of the final shielding analysis environment. ]]></summary_en></project><project>
<id>2675</id><title_hr><![CDATA[Pouzdanost konstrukcije oštećenog naftnog tankera u Jadranskom moru]]></title_hr><title_en><![CDATA[]]></title_en><user_id>810</user_id><user_firstLast_name>Joško Parunov</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2014-06</proposal_call><code>DOK-2014-06-5833</code><acronim><![CDATA[DATAS]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Brodogradnja, </scie_field_hr><scie_field_en>Naval architecture, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet strojarstva i brodogradnje]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Mechanical Engineering and Naval Architecture]]></institution_en><team_members_id>17787</team_members_id><team_members_names><![CDATA[ Doktorand: Ivana Gledić ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[oil tanker, Adriatic sea, damaged ship, structural reliability, risk assessment]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[The aim of the project is to propose methodology of structural safety assessment of the damaged oil tanker in the Adriatic Sea and to set-up procedure for rational decision making of ship in the situations requiring emergency response actions. This can also be used to develop more rational rules and regulations related to the traffic of large ships operating in the Adriatic and to investigate possibilities of a ship structural design improvement with respect to the most dangerous incident types. Despite advancements in navigation systems, ship accidents continue to occur, the most recent one being the grounding of a cruise ship Costa Concordia. These accidents have resulted in the loss of cargo, pollution of environment, and most unfavorable the loss of life. Accidental damages of ships can occur in any number of ways. The two cases which exhibit most concerns are the collision between ships and hard grounding on seabed. When a ship is damaged, the operators need to decide on immediate repair actions by evaluating the effects of the damage on safety of the ship by considering simultaneously effects of the damage in the hull girder ultimate bending moment and in the applied loads (wave and still-water induced bending moments). In general, as the consequence of an accident still water loads on ship will considerably increase, while the ship strength will decrease. Disaster of the tanker Prestige in 2002 clearly showed that the ship in damaged condition can be broken due to the above mentioned phenomenon and sink as the most unfavorable outcome of such an accident with likely spillage of a large amount of pollutant oil on board.Since the Adriatic is an enclosed sea basin, with the low level of the activity of the sea waves and current, an accident of the oil tanker with significant oil spill would make irreversible ecological disaster with enormous economic losses. Therefore, safety of oil transportation in the Adriatic is a major concern of the whole society.]]></summary_en></project><project>
<id>2676</id><title_hr><![CDATA[MULTIPLEX— Foundational Research on MULTIlevel comPLEX networks and systems, project number 317532]]></title_hr><title_en><![CDATA[]]></title_en><user_id>11143</user_id><user_firstLast_name>Vinko Zlatić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2014-06</proposal_call><code>DOK-2014-06-5324</code><acronim><![CDATA[]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, </scie_field_hr><scie_field_en>Physics, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>17748</team_members_id><team_members_names><![CDATA[ Doktorand: Andrea Kadović ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>2677</id><title_hr><![CDATA[Dynamic Management of Physically Coupled Systems of Systems (DYMASOS)]]></title_hr><title_en><![CDATA[]]></title_en><user_id>7618</user_id><user_firstLast_name>Mato Baotić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2014-06</proposal_call><code>DOK-2014-06-6214</code><acronim><![CDATA[]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Temeljne tehničke znanosti, </scie_field_hr><scie_field_en>Basic engineering sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id>17870</team_members_id><team_members_names><![CDATA[ Doktorand: Branimir Novoselnik ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>2678</id><title_hr><![CDATA[Preobrazba građanskog pravosuđa pod utjecajem globalnih i regionalnih integracijskih procesa. Jedinstvo i različitost / Transformation of Civil Justice under the Influence of Global and Regional Integration Processes. Unity and Diversity]]></title_hr><title_en><![CDATA[]]></title_en><user_id>3028</user_id><user_firstLast_name>Alan  Uzelac</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2014-06</proposal_call><code>DOK-2014-06-2989</code><acronim><![CDATA[]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Pravo, </scie_field_hr><scie_field_en>Law, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Pravni fakultet u Zagrebu]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Law]]></institution_en><team_members_id>17777</team_members_id><team_members_names><![CDATA[ Doktorand: Juraj Brozović ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>2679</id><title_hr><![CDATA[Otkrivanje novih proteinskih interakcija kao podloga za nove pristupe liječenju melanoma čovjeka]]></title_hr><title_en><![CDATA[]]></title_en><user_id>649</user_id><user_firstLast_name>Neda Slade</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2014-06</proposal_call><code>DOK-2014-06-1853</code><acronim><![CDATA[ProNetMel]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>17835</team_members_id><team_members_names><![CDATA[ Doktorand: Nikolina Hanžić ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[melanoma, protein interactions, p53, p73, nm23, Gli]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Metastatic melanoma represents a major clinical problem due to rising incidence and resistance to available therapies. Therefore, there is a necessity for developing novel molecular approaches to treat this disease. Unlike other tumors, in melanoma p53 is relatively rarely mutated. However, overexpressed p53 fails to function as a tumor suppressor and tumor cells continue to proliferate and spread. This suggests that regulation of p53 activity depends on the interplay between p53 and its binding partners. Based on current state of knowledge, we hypothesize that p53 function in malignant melanoma might be altered through the interactions with p53 small molecular weight and p73 isoforms, nm23/NDPK and Gli families of proteins. Thus we will search for p53 protein binding partners in melanoma. The interactions identified by mass spectrometry will be further confirmed using microarray-based approaches and co-immunoprecipitation techniques. Furthermore, the expression profile of genes/proteins of interest in panel of melanoma cell lines and melanoma tissue samples will be investigated. The potential impact of the identified p53 interacting partners on its transcriptional activity and the stimulation of apoptosis will be determined. The depletion of partners using siRNA technology would confirm the involvement of selected proteins on p53 activity. The subcellular localization of the proteins in complex will be revealed by advanced fluorescent microscopy methods on state-of-the-art instrumentation what would give us the insight on dynamics of their interactions. The proposed research could provide a possible explanation why p53 function in melanoma is abrogated. The aim of this project is to determine the complexity of p53 interactions and their role in the onset and progression of human melanoma and offer new, innovative solutions in diagnosis, prognosis and therapy.]]></summary_en></project><project>
<id>2680</id><title_hr><![CDATA[PONOVNA UPORABA MULJA S UREĐAJA ZA PROČIŠĆAVANJE OTPADNIH VODA U BETONSKOJ INDUSTRIJI - od mikrostrukture do inovativnih proizvoda]]></title_hr><title_en><![CDATA[]]></title_en><user_id>5991</user_id><user_firstLast_name>Dražen Vouk</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2014-06</proposal_call><code>DOK-2014-06-6363</code><acronim><![CDATA[RESCUE]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Građevinarstvo, </scie_field_hr><scie_field_en>Civil engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Građevinski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Civil Engineering]]></institution_en><team_members_id>17785</team_members_id><team_members_names><![CDATA[ Doktorand: Domagoj Nakić ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[Wastewater treatment, Sewage sludge, ISSA, Concrete, Microstructure, Sustainable materials]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[In the wastewater treatment process, a by-product is generated, as additional waste called sewage sludge (0.5 kg of sludge per 1 m3 of wastewater). Adequate wastewater management implies collection and treatment of wastewater, but also adequate management of waste substances generated in the treatment process. Joining the European Union Croatia has made the commitment to construct all treatment plants of capacities over 10.000 PE by 2018. This will result in putting into operation of treatment plants with the total load of about 4.000.000 PE (250.000.000 m3 of wastewater), which will generate about 215.000 tons per year of raw sewage sludge and after incineration around 49.000 tons per year of incinerated sewer sludge ash (ISSA). Taking into account that EU Directives are limiting the amount of sewage sludge waste to be landfilled, and Waste Framework Directive (2008/98/EC) puts reuse and recycling of waste into the most favorable position, it is evident that enormous amount of ISSA will become available for appropriate management.The composition of the generated sewage sludge and ISSA is dependent on the technology of wastewater and sludge treatment. Reviewing the available knowledge in this field leads to the conclusion that the influence of the method of incineration on physical properties of ISSA and the technology of preparing and processing of concrete and concrete elements has not been fully analysed. The main objective of the project is to investigate the possibilities of recycling the sludge from WWTPs in preparing of new innovative products in concrete industry. Based on comprehensive experimental research and multidisciplinary knowledge of the partners (hydrotecnical, materials and chemical engineering), a strategy will be proposed for the comprehensive and sustainable management of ISSA and its transformation from unwanted waste material into valuable resource for production of construction products with ecological, economical and technological benefits.]]></summary_en></project><project>
<id>2681</id><title_hr><![CDATA[Razvoj in vitro/ex vivo modela za ispitivanje permeabilnosti novih topičkih oftalmičkih lijekova]]></title_hr><title_en><![CDATA[]]></title_en><user_id>4075</user_id><user_firstLast_name>Jasmina Lovrić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2014-06</proposal_call><code>DOK-2014-06-5517</code><acronim><![CDATA[]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Farmacija, </scie_field_hr><scie_field_en>Pharmaceutical sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Farmaceutsko-biokemijski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Pharmacy and Biochemistry]]></institution_en><team_members_id>17861</team_members_id><team_members_names><![CDATA[ Doktorand: Bisera Jurišić ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>2682</id><title_hr><![CDATA[Dalmacija kao odredište europskog Grand Toura u 18. i 19. stoljeću]]></title_hr><title_en><![CDATA[]]></title_en><user_id>4910</user_id><user_firstLast_name>Irena Kraševac</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2014-06</proposal_call><code>DOK-2014-06-6881</code><acronim><![CDATA[GRANDTOURDALMATIA]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Povijest umjetnosti, </scie_field_hr><scie_field_en>Art history, </scie_field_en><institution_hr><![CDATA[Institut za povijest umjetnosti]]></institution_hr><institution_en><![CDATA[Institute of Art History, Zagreb]]></institution_en><team_members_id>5083</team_members_id><team_members_names><![CDATA[ Doktorand: Iva Raič Stojanović ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[Grand Tour, Dalmatia, Neoclassicism and Romanticism, Representation of Place, Contemporary Urbanscape]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Grand Tour – an exceptional journey which reached its peak in the 18th C, thoroughly changed human perception of nature and society. From the 18 to the 19th C the revolution in natural, human and technical sciences marks the beginning of modern society and contemporary approach in arts and architecture.Although Grand Tour originally focused on Rome, the exploration of  the Ancient World as the origin of Neolassicism widened its travelling radius onto further parts of the Roman Empire, among which Dalmatia held a prominent position. Drawings and literary works by travel artists and writers from that period are treasured in prestigious European museums and libraries and together constitute a priceless  portion of European cultural heritage.For the first time, all known travelogues and drawings about Dalmatia from that period will be collected, analysed and evaluated in terms of literary theory and theory of architecture. The overall aim of the project is to identify, problematise and integrate the issues related to the phenomenon of recording the space, predominantly in Dalmatia. The specific goals of the project are: establishing a working group of young researchers; raising issues of international relevance related to description of Dalmatian space based on works of the 18th and  19th C artists and writers; advancing the development of research methodology; making applicable the research of contemporary cultural-spatial context for critical rethinking in contemporary approach to architecture; creating a platform for further research at international level; establishing a dissemination channel towards both European scientific circles and wider audience.In three years of research the following will be realised: the research of archival records; field research; project webpage; three international workshops; international scientific  conference; public lectures; scientific papers and on-line proceeding book of workshops and conference.]]></summary_en></project><project>
<id>2683</id><title_hr><![CDATA[Inovativno pametno poduzeće]]></title_hr><title_en><![CDATA[]]></title_en><user_id>2921</user_id><user_firstLast_name>Ivica Veža</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2014-06</proposal_call><code>DOK-2014-06-2672</code><acronim><![CDATA[INSENT]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Strojarstvo, </scie_field_hr><scie_field_en>Mechnical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Splitu, Fakultet elektrotehnike, strojarstva i brodogradnje]]></institution_hr><institution_en><![CDATA[University of Split, Faculty of Electrical Engineering, Mechanical Engineering and Naval Architecture]]></institution_en><team_members_id>17852</team_members_id><team_members_names><![CDATA[ Doktorand: Ivan Peko ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[innovation, smart enterprise, learning factory, production systems, business model]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[The introduction of the Internet of Things and Services into the manufacturing environment is ushering in a fourth industrial revolution: Industry 4.0. This new type of industry is based on Smart Factory model or Smart Enterprise. The main features of Smart Enterprise can be summarized into the following: smart personalized product, product and service provider, and high level of collaboration.Manufacturing is today, as it always has been, a cornerstone of the economy of developed nations. An important advantage of manufacturing is that it calls on the skills of everyone from entry-level factory workers to scientists, engineers, and business professionals. Hence, main focus of this project will be Manufacturing Enterprises. Vision of Innovative Smart Enterprise for next generation manufacturing can be summarized into following features: Lean, Flexible, Agile, Efficient, Responsive, Information Enabled, Predictive, and Safe. All these features result with long term sustainability.The main objective of this project is to develop Croatian model of Innovative Smart Enterprise (HR-ISE model). Hence, a profound research will be performed to describe current state of Croatian manufacturing enterprise. It will be the answer on the question: “Where are we?”Furthermore, a synthesis of analysis of Croatian manufacturing enterprises will be done through development of HR-ISE model. It will be the answer on the question: “Where we want to be?”Finally, a special learning environment will be established: Learning Factory. It will be a place in which transfer of developed HR-ISE model to the economy subjects will be achieved. It will be the answer on the question: “How can we get there?”Results of this project will be of the highest value for “fallen” Croatian industry. The development of HR-ISE model and its transfer to economy can have strong impact on recovery of Croatian industry, and it can significantly improve competencies and capabilities of Croatian enterprises.]]></summary_en></project><project>
<id>2685</id><title_hr><![CDATA[3D sustav za mjerenje oblika trupa tijela]]></title_hr><title_en><![CDATA[]]></title_en><user_id>6456</user_id><user_firstLast_name>Tomislav Pribanić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2014-06</proposal_call><code>DOK-2014-06-8227</code><acronim><![CDATA[3DHumanTorso]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Računarstvo, </scie_field_hr><scie_field_en>Computer sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id>17809</team_members_id><team_members_names><![CDATA[ Doktorand: Matea Đonlić ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[3D reconstruction, structured light, passive stereo, scoliosis, degenerative disease, 3D  spine shape]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[The aim of this work is to develop a low-cost automated system to measure the three- dimensional shape of the back and front of the human torso. It will enable numerous physicians to acquire the trunk surface (TS). TS symmetry is one of the key elements in diagnostic and evaluation of various treatments in patients with trunk deformities. Common radiographic evaluation methods are known to expose patients to a radiation and, besides, radiography is actually 2D representation of 3D problem which has been shown not to be directly related to the shape of the back. Thus, there has been a constant motivation among researchers at (inter)national level to develop an optimal methodology for 3D reconstruction of the back. Still, most of those developed systems are mainly directed to 3D reconstruction of the spine and calculation of the Cobb angle which is still regarded by many as the gold standard method to measure scoliotic deformity. Still, the Cobb angle alone cannot explain the whole of the surface deformity. Evidently, there is high need to investigate development of a 3D reconstruction system which will capture both back and front of the patient, i.e. the entire trunk surface. In turn it would enable a more thorough analysis of the patient’s deformity pattern, i.e. a second major goal during this project is to derive other parameters (not only Cobb angle) in order to quantify trunk deformities. In designing 3D system we underline that we plan to research the implementation of both passive and active stereovision strategies. Researching the implementation of combined best features from passive and active stereo for one concrete of 3D system aimed at TS reconstruction (scoliosis), would be a great contribution for potential other 3D applications. Degenerative diseases of spine represent a serious social problem in Croatia. More than 10% of population has frequent problems with it. Clearly, every research contribution for this matter would be an extremely valuable asset.]]></summary_en></project><project>
<id>2686</id><title_hr><![CDATA[Starosno-ovisna ekspresija membranskih prijenosnika u štakora]]></title_hr><title_en><![CDATA[]]></title_en><user_id>1396</user_id><user_firstLast_name>Ivica Rubelj</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2014-06</proposal_call><code>DOK-2014-06-6992</code><acronim><![CDATA[AGEMETAR]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Biologija, </scie_field_hr><scie_field_en>Biology, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>19039</team_members_id><team_members_names><![CDATA[ Doktorand: Lucia Nanić ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[aging, antioxidants, drug transporters, hepatotoxicity, liver, kidney, Klotho, membrane transporters, nephrotoxicity, oxidative stress,  telomeres ]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Aging is a physiological process characterized by a gradual decline in physical fitness and other functional capabilities. The mechanisms of aging and possible actions of slowing down or ameliorating aging-related processes are poorly understood. In humans, one of the characteristics of old age is polypharmacy, which elevates risks of drug-drug interactions and drug-induced adverse reactions and organ toxicity, such as hepatotoxicity and nephrotoxicity. These reactions may partially result from diminished drug metabolism and/or mainly from impaired activity/expression of various membrane transporters that are responsible for drug excretion in liver and kidneys. These both mechanisms have been poorly studied in senescent organs. Here we promote a hypothesis that the aging-induced oxidative stress, known to downregulate the activity/expression of the aging suppressor gene (Klotho) and to shorten the length of telomeres, also diminishes the activity/expression of various membrane transporters in liver and kidneys, and that these changes can be ameliorated by treating animals with antioxidants resveratrol and melatonin. The extent and the intensity of aging-related changes, and the beneficial effects of antioxidants may be sex-related. To test this hypothesis, we propose various biochemical and cell- and molecular-biological studies of aging parameters and aging-dependent expression of various membrane transporters in the mammalian liver and kidneys using a rat model of experimental aging. Possible aging-related decline in the expression of these transporters may explain a higher incidence (women > man) of drug interactions and toxicity in old people. The studies will define the underlying cellular mechanisms that contribute to generation of the aging-related pathophysiological conditions in the liver and kidneys, and will indicate possible ways of their amelioration. Positive results may point to remedies to be used for improving the health of elderly people.]]></summary_en></project><project>
<id>2687</id><title_hr><![CDATA[Methods for high-throughput glycoproteomic analysis“ (HTP GlycoMet)]]></title_hr><title_en><![CDATA[]]></title_en><user_id>7807</user_id><user_firstLast_name>Djuro  Josic</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2014-06</proposal_call><code>DOK-2014-06-1373</code><acronim><![CDATA[]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Biotehnologija, </scie_field_hr><scie_field_en>Biotechnology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Fakultet biotehnologije i razvoja lijekova]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Biotechnology and Drug Development]]></institution_en><team_members_id>12865</team_members_id><team_members_names><![CDATA[ Doktorand: Tamara Martinović ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>2688</id><title_hr><![CDATA[Upravljanje povjerenjem i koordinacija interakcija u pametnim mrežama ljudi, strojeva i organizacija]]></title_hr><title_en><![CDATA[]]></title_en><user_id>2612</user_id><user_firstLast_name>Gordan Ježić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2014-06</proposal_call><code>DOK-2014-06-1586</code><acronim><![CDATA[SmartPMONetworks]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Elektrotehnika, </scie_field_hr><scie_field_en>Electrical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id>25471</team_members_id><team_members_names><![CDATA[ Doktorand: Matea Žilak ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[social networks, machine-to-machine communication, networked organizations, networked society, trust, coordination, context-awareness, big data]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[We live in a networked society where everything is connected. By 2020 there will be 8 billion people and 50 billion machines in the world and almost all of them will be connected through some kind of network. Furthermore, people and machines that share a certain collective goal will be grouped into some kind of organization, which again will be connected with other organizations and/or people/machines. In order to maintain sustainability of the networked society we need a framework and algorithms which will enable us to i) manage trust; and ii) coordinate interactions in such a complex eco-system consisting of thousands, millions or even billions of interconnected entities. Both the framework and algorithms should be scalable and robust (from the perspective of a network size and heterogeneity), support real-time dynamics (from the perspective of network interactions) as well as be applicable and analyzable at different levels of granularity (at a micro, mezzo and macro network levels). A possible solution for the framework is the “Smart Network”, where people/machines/organizations are represented as nodes which are described by profiles and build a network of connections. The “smartness” of “Smart Networks” stems from profiling nodes and realizing connections using automated computational methods, what is enabled by latest enhancements in information systems and state-of-the-art solutions in communication technologies. The “Smart Network” framework enables design of scalable, robust and real-time algorithms for managing trust and coordinating interactions because it can be i) formally operationalized as a graph where edges represent nodes and vertices represent connections; ii) functionally modeled as a multi-agent system where agents embody edges and relationships embody vertices; and iii) analyzed through complexity theory where sustainable solutions emerge as a result of a bottom-up modeling principle.]]></summary_en></project><project>
<id>2690</id><title_hr><![CDATA[Karakterizacija reakcije osteoklastnih progenitora na artritis]]></title_hr><title_en><![CDATA[]]></title_en><user_id>3075</user_id><user_firstLast_name>Danka Grčević</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2014-06</proposal_call><code>DOK-2014-06-8382</code><acronim><![CDATA[COPERA]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb School of Medicine]]></institution_en><team_members_id>17836</team_members_id><team_members_names><![CDATA[ Doktorand: Darja Flegar ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[osteoclasts, arthritis, inflammation, progenitors, differentiation, cytokines, chemokines]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Chronic joint diseases affect more than a third of the world’s population and represent a major health problem. Several forms are classified in clinical practice, depending on the main pathogenic mechanism: osteoarthritis, rheumatoid arthritis (RA) and spondyloarthritis Collagen-induced arthritis (CIA) is a widely used mouse model of RA and is still an indispensible tool to study the disease pathogenesis. Through the production of osteoresorptive mediators by immune cells, chronic inflammation in arthritis creates a microenvironment that promotes osteoresorption by osteoclasts (OC). OCs are multinucleated bone-resorbing cells arising from myeloid hematopoietic lineage. A number of systemic and local stimuli, such as hormones and cytokines/chemokines, promote osteoclastogenesis by enhancing OC differentiation, migration, activation, lifespan and function, but the exact mechanisms of how the inflammatory network works in vivo in the context of arthritis are largely unclear. Particularly, the human osteoclast progenitor (OCP) populations are not precisely defined and it is, as yet, unknown which critical mediators have the potential to activate OCPs and attract them to produce joint lesions. Using the mouse model of CIA and samples from arthritic patients we propose to elucidate differentiation sequence of early progenitors into mature OCs, shifts in the frequency of discrete OCP subpopulations and their migration patterns during arthritis. We plan to identify distinct OCP subpopulations in the bone marrow, periphery and joint lesions, their migratory and homing patterns, and their functional links to bone loss in arthritis. We expect to define the properties of inflammatory microenvironment in the regulation of OC trafficking, differentiation and activity in arthritis. A better characterization of arthritis-induced OCP subpopulations could offer the potential to design therapeutic approaches to control their migration and curtail their osteoresorptive potential.]]></summary_en></project><project>
<id>2691</id><title_hr><![CDATA[Europski FP7 projekt „GlowBrain - Primjena matičnih stanica i biomaterijala u oporavku mozga - unapređivanje mogućnosti postojećeg istraživanja mozga kroz inovativno in vivo molekularno oslikavanje“ ]]></title_hr><title_en><![CDATA[]]></title_en><user_id>11180</user_id><user_firstLast_name>Marija Ćurlin</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2014-06</proposal_call><code>DOK-2014-06-8752</code><acronim><![CDATA[]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb School of Medicine]]></institution_en><team_members_id>19179</team_members_id><team_members_names><![CDATA[ Doktorand: Marta Skelin ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>2692</id><title_hr><![CDATA[Utvrđivanje sastava crijevne mikrobiote, upalnih markera, prehrambenog i endokrinog statusa u pacijenata s upalnom bolesti crijeva]]></title_hr><title_en><![CDATA[]]></title_en><user_id>5552</user_id><user_firstLast_name>Donatella Verbanac</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2014-06</proposal_call><code>DOK-2014-06-6863</code><acronim><![CDATA[MINUTE for IBD]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb School of Medicine]]></institution_en><team_members_id>13628</team_members_id><team_members_names><![CDATA[ Doktorand: Marina Panek ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[IBD, microbiota, blood biomarker, tissue, translational research, clinical research]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Inflammatory bowel disease (IBD) is a chronic gastrointestinal disorder with increase in incidence that severely deteriorates patients’ quality of life. The onset of the disease is mainly associated with the immune status, gut microbiota and food intake. The current scientific knowledge of specific triggers and diagnostic markers is limited; therefore, new data on gut microbiota, inflammatory, endocrine and nutritional status are required to better understand the IBD pathophysiology.It this study we will thoroughly explore host-gut microbiota interactions in order to define novel strategies for management of IBD.We will collect intestine biopsies, stool and blood samples from 40 newly diagnosed IBD patients and 20 non-IBD control individuals, as well as record their nutritional status. Since majority of the gut microorganisms are not culturable, we will use the in house available next-generation sequencing to characterize the composition of the microbiota in collected samples. Moreover, specific blood biomarkers, including cytokines, growth factors and hormones, will be determined using novel and highly sensitive proximity extension assays, recently developed in our laboratories. Collectively, these results will support better stratification of patients and initiate an appropriate therapy.]]></summary_en></project><project>
<id>2693</id><title_hr><![CDATA[Između Dunava i Mediterana. Uloga rimske vojske u mobilnosti ljudi i roba na tlu Hrvatske u antici. ]]></title_hr><title_en><![CDATA[]]></title_en><user_id>4028</user_id><user_firstLast_name>Mirjana Sanader</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2014-06</proposal_call><code>DOK-2014-06-6088</code><acronim><![CDATA[RoMiCRO]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Arheologija, </scie_field_hr><scie_field_en>Archeology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Filozofski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Humanities and Social Sciences]]></institution_en><team_members_id>17731</team_members_id><team_members_names><![CDATA[ Doktorand: Mirna Vukov ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[Roman Empire, Danube, Mediterranean, mobility, economy, Roman military, local elite.]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[The objective of the project is to investigate and extend scientific information to aid in solving as yet unanswered questions about the significance of the Roman military in changes that occurred on the territory of Republic of Croatia in the period from the first contacts with Rome (229 BC) to the end of the Marcomannic Wars (180 AD). The geopolitical strategy of Rome in conquered regions was to encourage the integration process, where the Roman army gave its contribution. Archaeological data testify that the indigenous communities of Illyricum reacted differently to this process. Some were willing to accept the Roman heritage (e.g. Liburnians), while the others (e.g. Delmatae) were providing resistance. Given previous research today we have a number of valuable studies about certain aspects of Roman domination. However, they are primarily focused either on the ancient written sources or the archaeological material from Dalmatia and Pannonia. This research of the integration would cover for the first time the Roman military presence on the area of Croatia. The main focus is on the Roman military sites along the Dalmataean and the the Danube limes. New data will be derived using the methodology purposely created for this project and includes archaeological survey, classification, comparison and evaluation of all available data both archaeological and ancient sources with the application of the variable of geographic origin. Such research has never been undertaken in Croatia. The results would fill the informational gaps that exist for this part of the Empire through the analysis of the largest possible amount of information about the Roman army activities and the integration of indigenous people. The project leader’s research has focused so far on the problems of Roman provincial archaeology. Many years of her successful research of and of all the collaborators guarantee the sustainability of the approach and the successful implementation of the project objectives.]]></summary_en></project><project>
<id>2694</id><title_hr><![CDATA[Molekularna epidemiologija nekih invazijskih oboljenja divljih životinja]]></title_hr><title_en><![CDATA[]]></title_en><user_id>3919</user_id><user_firstLast_name>Dean Konjević</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2014-06</proposal_call><code>DOK-2014-06-2264</code><acronim><![CDATA[EpiMol]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Veterinarska medicina, </scie_field_hr><scie_field_en>Veterinary medicine, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Veterinarski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Veterinary Medicine]]></institution_en><team_members_id>17766</team_members_id><team_members_names><![CDATA[ Doktorand: Miljenko Bujanić ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[molecular epidemiology, wildlife, parasitology, MHC genes, GIS modelling]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Wildlife diseases are increasingly important field of veterinary medicine, conservation medicine, and protection of human health. Of all wildlife diseases parasitic diseases participate with 75%. In this project, selection of diseases encompasses potentially fatal diseases with high economic impact, frequently present disease with mainly subclinical course, and potential zoonotic diseases. Main objectives of the project are to: 1) determine the occurrence of selected parasitic diseases of gastrointestinal and respiratory system in red deer, roe deer, wild boar and jackal, 2) determine environmental factors that contribute disease occurrence, 3) determine the epidemiology of selected parasitic disease of wildlife, 4) analyse MHC genes expression in animals with different health status, and 5) analyse obtained results with molecular epidemiology tools. This will be achieved by interdisciplinary research team (composed of veterinarians, biologists and forester) divided in four main topics: parasitology, environmental conditions and GIS modelling, MHC genes polymorphism in wildlife and epidemiology and molecular epidemiology. Other objectives of the project are to facilitate establishment of internationally competent multidisciplinary research team through research, cooperation and continuing professional development and to enhance development of molecular epidemiology in Croatia. With such comprehensive approach proposed project offers for the first time in Croatia creation of multidisciplinary team that will analyse all aspects of wildlife diseases and important environmental factors. Furthermore, molecular epidemiology will provide insights into susceptibility to disease and potential survival rate that is dependent on major histocompatibility complex variations.]]></summary_en></project><project>
<id>2695</id><title_hr><![CDATA[Constraining AGN feedback through cosmic times: Paving the way for the next generation radio facilities]]></title_hr><title_en><![CDATA[]]></title_en><user_id>11144</user_id><user_firstLast_name>Vernesa Smolcic</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2014-06</proposal_call><code>DOK-2014-06-4630</code><acronim><![CDATA[]]></acronim><duration></duration><status>Prekinut</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, </scie_field_hr><scie_field_en>Physics, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>19125</team_members_id><team_members_names><![CDATA[ Doktorand: Nikola Baran ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>2696</id><title_hr><![CDATA[Hijerarhijska konsolidacija velikih potrošača temeljena na upravljanju za integraciju u napredne mreže]]></title_hr><title_en><![CDATA[]]></title_en><user_id>7612</user_id><user_firstLast_name>Mario Vašak</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2014-06</proposal_call><code>DOK-2014-06-7386</code><acronim><![CDATA[3CON]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Elektrotehnika, </scie_field_hr><scie_field_en>Electrical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id>17458</team_members_id><team_members_names><![CDATA[ Doktorand: Hrvoje  Novak ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[optimal control, hierarchical control, building, railway traffic system, energy consumption, power flow optimisation, prosumer, smart grid]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Buildings and railway traffic systems are examples of complex technical systems that consume significant energy amounts so as to enable their inner processes to evolve as required. Thereby the requirements on dynamic functioning of these systems can be achieved by different system interactions, whereas some of them are more preferable than the others from the standpoints of energy consumption or other criteria like price of operation or equivalent pollution.The global objective of the project 3CON is to research and develop optimal control techniques on significantly different large consumers – building systems and railway traffic systems – in conceptually identical way: by applying the principle of hierarchical decomposition of systems and cooperative optimal controls between the hierarchy levels. In that way the computed energy consumption profile on the lower level directly maximizes the global economic gain of the system operation in the presence of system constraints (e.g. allowed temperatures or fixed train travelling time). This will enable the proactive role of these largest consumers in energy grids of the future (smart grids). It will make them responsive and in position to best exploit the imposed varying energy exchange terms. Thereby vast possibilities in energy grid management through dynamic pricing will be opened – foremost for reducing losses between generation and consumption points in the grid and increasing grid reliability. The secondary global objective of this installation grant is to build an internationally competent research group in control of energy-intensive systems on the Faculty which is also recognized and accepted by relevant domestic companies.The project developments will be verified through building and railway traffic case studies that will be supervised by relevant Croatian companies. This will ensure that all relevant system issues are taken care of in the design and that the design itself is close to exploitation.]]></summary_en></project><project>
<id>2697</id><title_hr><![CDATA[Očuvanje genofonda šumskog drveća u svjetlu klimatskih promjena]]></title_hr><title_en><![CDATA[]]></title_en><user_id>5275</user_id><user_firstLast_name>Mladen Ivanković</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2014-06</proposal_call><code>DOK-2014-06-9784</code><acronim><![CDATA[ConForClim]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Šumarstvo, </scie_field_hr><scie_field_en>Forestry, </scie_field_en><institution_hr><![CDATA[Hrvatski šumarski institut]]></institution_hr><institution_en><![CDATA[Croatian Forest Research Institute]]></institution_en><team_members_id>17850</team_members_id><team_members_names><![CDATA[ Doktorand: Sanja Mrmić ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[Genetic conservation, Climate changes, Forest , provenance trials, variability, Quercus robur, Fagus sylvatica ]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[The preserving of the genetic diversity of the forest types is the basis for sustainable management and conservation of the natural composition of the forests. Natural forests make up 95% of the total forests in Croatia and in its wealth geographic region contains different ecological types and a large number of the forest tree species. Global climate changes, rising temperatures, falling rainfall, occurrence of the extreme weather events directly affect on genetic diversity. The main objective of the proposed project is to make recommendations for the conservation of the genetic diversity of the forest trees. Precondition for achieving the goal is the identification and understanding of the genetic variability of the individual tree species. The research to be carried out by the project would be based on the common oak and beech. On existing genetic tests that were established at different sites, data on the survival and growth of plants, phenology, silvicultural properties, plant resistance to pests, etc should be collect. The stem forest stands from which the seed was taken will be used for collecting the data of health condition, fruiting and climatic parameters. The genetic diversity of the provenance will be analyzed by DNA markers. This project should be continued and expanded research on the identification of proven European beech resistant to drought, which are conducted in the framework of a bilateral cooperation with Germany (MSES-DAAD 2013/14) and the preservation of the gene pool and study of the variability of our most important tree species which are conducted as part of the project “Breeding and forest seed” supported by MSES of Croatia. From the economic point of view, the project aims is to raise the category of the forest reproductive material (FRM) in a higher category according to the Law of FRM (Official Gazette 75/2009, 61 /2011 - EU directive EC/105/99). Higher category guarantees a higher quality, and thus a higher price in the market.]]></summary_en></project><project>
<id>2698</id><title_hr><![CDATA[Moderne i suvremene umjetničke mreže, umjetničke grupe i udruženja: Organizacijski i komunikacijski modeli suradničkih umjetničkih praksi 20. i 21. stoljeća]]></title_hr><title_en><![CDATA[]]></title_en><user_id>6142</user_id><user_firstLast_name>Ljiljana Kolešnik</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2014-06</proposal_call><code>DOK-2014-06-5766</code><acronim><![CDATA[ARTNET]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Povijest umjetnosti, </scie_field_hr><scie_field_en>Art history, </scie_field_en><institution_hr><![CDATA[Institut za povijest umjetnosti]]></institution_hr><institution_en><![CDATA[Institute of Art History, Zagreb]]></institution_en><team_members_id>17659</team_members_id><team_members_names><![CDATA[ Doktorand: Nikola Bojić ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[history of art, methodology, artist networks, art groups, social networks, data visualization, Croatian modern art, Croatian contemporary art]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Research topics of this project are the organization and communication models embedded into artist networking and artist collaborative practices of the 20th and 21st century, as they are manifested in the Croatian art of that period. Project initial hypothesis is that artist networks, art groups and art associations form the most important platform of cultural exchange in modern and contemporary visual arts due to the similarity of underlying organization and communication models regardless of geo-cultural location at which they appear. A degree of their diversity in art practice of particular local community at particular historical moment is proportional to the dynamics and volume of its participation in the international/cross-cultural exchange. To prove our hypothesis and identify, describe and explain these organization and communication models as generally applicable – which is the main objective of the project - we shall investigate Croatian artist networking and collaborative practices on the background of similar phenomena in other European countries and with regard to poetic requirements of different periods in modern and contemporary art, conventions of social interactions and available techniques/technologies of communication. As the methodology of art history does not meet the complexity of the research topic, we shall develop interdisciplinary methodological apparatus combining knowledge and analytic tools of art history, sociology and information science. Considerable amount of data collected through the extensive infield research will be stored in Croatian Artists Networks Information System developed in the course of the project and supporting network visualization techniques as a cognitive research tool for experimental presentation of our research results framed with the appropriate structural narratives (textual, visual, GIS data). Project results will be also presented in 2 books, 7 articles and at the closing international conference.]]></summary_en></project><project>
<id>2820</id><title_hr><![CDATA[Znanstvena aktivnost, suradnja i orijentacija istraživanja u društvenim znanostima u Hrvatskoj i ostalim postsocijalističkim europskim zemljama]]></title_hr><title_en><![CDATA[Research activity, collaboration and orientation in social sciences in Croatia and other post-socialist European countries]]></title_en><user_id>6932</user_id><user_firstLast_name>Marija Maja Jokić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2014-09</proposal_call><code>IP-2014-09-9351</code><acronim><![CDATA[RACOSS]]></acronim><duration>15.09.2015 - 14.09.2019</duration><status>Završio</status><financ_value>70.182,49 eur</financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Informacijske znanosti, Ekonomija, Pravo, Politologija, Sociologija, Psihologija, Pedagogija, Edukacijsko-rehabilitacijske znanosti, Socijalne djelatnosti, </scie_field_hr><scie_field_en>Information sciences, Economy, Law, Political Science, Sociology, Psychology, Pedagogy, Physical education and rehabilitation sciences, Social work, </scie_field_en><institution_hr><![CDATA[Institut za društvena istraživanja]]></institution_hr><institution_en><![CDATA[Institute for Social Research in Zagreb]]></institution_en><team_members_id>7722, 11177, 12381, 11224, 6920, 7724, 12373, 12341, 20965, </team_members_id><team_members_names><![CDATA[Dejana Bouillet, Andrea Mervar, Krešimir Kufrin, Darja Maslić Seršić, Nikola Petrović, Sonja Špiranec, Dora Zgrabljić Rotar, Tonči  Kursar, Stjepan Mateljan, ]]></team_members_names><keywords_hr><![CDATA[znanstvena aktivnost, citatne analize, znanstvena suradnja, analiza društvenih mreža¸ nacionalni časopisi, društvene znanosti, Hrvatska, EU zemlje]]></keywords_hr><keywords_en><![CDATA[research performance, citation analysis, collaboration, social network analysis, natioanl journals, social sciences, Croatia, EU countries]]></keywords_en><summary_hr><![CDATA[Temeljna funkcija znanosti, posebno društvenih, je utjecaj na razvoj društva. Status društvenih znanosti u društvu, kao i njihov utjecaj na razvoj, manje su istraživane teme u odnosu na prirodne i primijenjene znanosti.U Hrvatskoj se društvenim znanostima bavi približno četvrtina registriranih znanstvenika vezanih najvećim dijelom uz rad 7 instituta i svih 7 sveučilišta. Glavna istraživačka pitanja ovog projekta su: Kojim temama i kakvom problematikom se bave ti stručnjaci? Gdje objavljuju rezultate svojih istraživanja? Surađuju li međusobno unutar ustanova, na razini zemlje i na međunarodnoj razini? U kojoj mjeri su rezultati njihovih istraživanja dostupni i prepoznati kroz citiranost? Kakav je značaj i uloga nacionalnih časopisa iz društvenih znanosti u prijenosu i dostupnosti znanja? Postoje li razlike u obrascima znanstvenog komuniciranja u pojedinim poljima društvenih znanosti i koje su? Kako bi se dobila što cjelovitija slika stanja u Hrvatskoj, u projekt su uključene europske post-socijalističke zemlje, 10 EU zemalja i zemlje bivše Jugoslavije. Za ostvarivanje postavljenih ciljeva koristit će se kvantitativni (bibliometrija, upitnici, analiza društvenih mreža) i kvalitativni (intervjui) metodološki pristupi koje je osmislio i provodit će interdisciplinarni tim stručnjaka. Temeljni izvor podataka o produktivnosti, citiranosti, autorstvu, suradnji, časopisima, ustanovama i zemljama je baza Scopus. Za statističke podatke o zemljama koristi će se Eurostat i razni nacionalni izvori.Očekivani doprinosi projekta su teorijski i primijenjeni, od uvida u znanstveni potencijal u istraživanjima društvenih znanosti uključenih zemalja, preko razvoja i primjena kompleksne metodologije prikupljanja i obrade raznovrsnih podataka, do ponude relevantnih elementa hrvatskoj znanstvenoj politici i indikatora za razvoj i primjenu prihvatljivijih sustava za vrednovanje znanstvenog rada te pomoć pri donošenju vezanih odluka.]]></summary_hr><summary_en><![CDATA[A basic function of science, especially social science, is its influence on the development of society. The status of social science and its influence on the development of society are less researched themes in comparison with natural and applied sciences.Nearly a quarter of registered Croatian scientists are social scientists. Their work is, in most part, tied to the work of 7 scientific institutes and all 7 universities. The main research questions in this project are: Which themes and problematic are central to these experts? Where do they publish the results of their research? How much do they cooperate on institutional, country and international level and are there measurable effects of cooperation? To what extent are their results available and recognized through citations? What is the significance and role of national journals in social sciences? What are the differences between various fields of social sciences?To provide a rich comparative description of the state of social sciences in Croatia, the project includes 10 EU post-socialist countries as well as ex-Yugoslav countries. To attain its goals the project will use quantitative (bibliometry, survey, social network analysis) and qualitative (interviews) methods which have been planned and will be implemented by a multidisciplinary team of experts. The primary source for bibliometric data for productivity, impact, authorship, cooperation, journals, institutions and countries will be the Scopus citation index. The main source for statistical data about the included countries will be Eurostat and various national sources.The expected outcomes of the project are theoretical and applied, from insight in scientific potential of social science research in included countries, through the development of appropriate methods of collecting and analyzing different types of data, to offering the relevant elements and indicators for the evaluation of scientific output and as help in related decision making processes.]]></summary_en></project><project>
<id>2834</id><title_hr><![CDATA[Patofiziološke posljedice promjena sastava lipidnih splavi]]></title_hr><title_en><![CDATA[Pathophysiological consequences of lipid raft changes]]></title_en><user_id>4409</user_id><user_firstLast_name>Marija Heffer</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2014-09</proposal_call><code>IP-2014-09-2324</code><acronim><![CDATA[RafTuning]]></acronim><duration>10.12.2015 - 09.06.2021</duration><status>Završio</status><financ_value>130.743,91 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, Farmacija, </scie_field_hr><scie_field_en>Basic Medical Sciences, Pharmaceutical sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište Josipa Jurja Strossmayera u Osijeku, Medicinski fakultet Osijek]]></institution_hr><institution_en><![CDATA[Josip Juraj Strossmayer University of Osijek, Faculty of Medicine]]></institution_en><team_members_id>12600, 12492, 13131, 2737, 4439, 4511, 12488, 4384, 4379, 12468, 4417, 13292, 4420, 13221, 13217, 13317, 4473, 23157, 23158, 23159, 23162, 23166, 23167, 23165, 23171, </team_members_id><team_members_names><![CDATA[Svjetlana Kalanj Bognar, Kristina Mlinac, Dragana Fabris, Jasenka Wagner, Barbara Viljetić, Vedrana Ivić, Ivana Škrlec, Marta Balog, Senka Blažetić, Valentina Pavić, Robert Blažeković, Željka Vukelić, Irena  Labak, Milan Mesić, Melita Čačić Hribljan, Zrinka Požgain, Stefan Mrđenović, Alen Imširović, David Andrijevic, Kiš Ana, Tihana Mendeš, Martina Matanović, Tea Markulak, Mateo Čupić, Andrijana Včeva, ]]></team_members_names><keywords_hr><![CDATA[lipidne splavi, gangliozidi, živčani sustav, inhibitori glikolipida, stres, epigenetika]]></keywords_hr><keywords_en><![CDATA[lipid rafts, gangliosides, nervous system, glycolipid inhibitor, stress, epigenetics]]></keywords_en><summary_hr><![CDATA[Lipidne splavi su područja stanične membrane koja okupljaju lipide i 35% proteina membrane u dinamične strukture zvane signalosomi. Glavne molekule koje sudjeluju u izgradnji lipidnih splavi su kolesterol, sfingomijelin i glikosfingolipidi. Najmanje 11% transmembranskih proteina ovisi o glikosfingolipidima, posebice gangliozidima, koji osiguravaju pravilnu strukturu i funkciju lipidnih splavi.  Promjene u sastavu glikosfingolipida moduliraju kritične korake u fiziološkim procesima kao što su adhezija, signalizacija, formiranje barijera, stanična migracija, vezikularni transport i apoptoza. Također, rani su pokazatelji neurodegenerativnih poremećaja (Alzheimer i Parkinson). Mehanizmi koji dovode do promjena nisu dovoljno istraženi i ne postoje terapije usmjereno na lipidne splavi kod liječenja neurodegenerativnih bolesti i pospješivanja regeneracije. Cilj istraživanja je testirati jeli sastav lipidnih splavi narušen kod genetički izmijenjenih miševa s nedostatkom u sintezi gangliozida, jeli se mijenja pod utjecajem stresa i u procesu starenja te može li se farmakološki manipulirati satavom lipidnih splavi. U svrhu dokazivanja postavljene hipoteze utvrditi će se promjene u sastavu lipidnih splavi i transkriptomu središnjeg i perifernog živčanog sustava kod miševa s nedostatkom u sintezi gangliozida odnosno na  štakorskom modelu kroničnog stresa i starenja. Sintetizirati ćemo inhibitore ključnih enzima u metabolizmu glikolipida koji bi mogli poslužiti u farmakološkim intervencijama i dalje ih sistematizirati  prema djelovanju na sastav lipidnih splavi u kulturama živčanih stanica i na mišjem modelu. Kombinacijom lipidomičkog i transkriptomičkog pristupa odabrat će se kritični signalni putovi i utvrditi njihov učinak na epigenetske promjene. Genetički, okolišem i farmakološki inducirane promjene u sastavu lipidnih splavi dati će uvid u njihovu funkciju i omogućiti razvoj lijekova namijenjenih finom ugađanju  procesa kao što su reakcija na stres i regeneracija.]]></summary_hr><summary_en><![CDATA[Lipid rafts are liquid ordered sub-compartments of plasma membrane which co-cluster lipids and 35% of plasma-membrane proteins in dynamic structures called signalosomes. Cholesterol, sphingomyelin and glycosphingolipids are the major constituents and organizers of lipid rafts. At least 11% of transmembrane proteins depend on glycosphingolipids, particularly gangliosides, as lubricant enabling proper raft location and function. Changes in composition of glycosphingolipids interfere with fine tuning of critical physiological processes like adhesion, signaling, forming barriers, cell migration, vesicular transport and apoptosis. Although changes in the ganglioside content of lipid rafts are the first sign of neurodegenerative diseases like Alzheimer and Parkinson, mechanisms causing changes are not fully explored and there are no relevant clinical treatments targeting rafts in neurodegeneration or regeneration. With this proposal we aim to test whether the content of lipid rafts is disrupted in knockout mice for the key enzymes in ganglioside synthesis, affected in stress and aging and could it be successfully tuned by pharmacological manipulation. In order to test this hypothesis we will map the changes in lipid rafts and the transcriptome of CNS and PNS of ganglioside-deficient knockout mice and rat models of aging and chronic stress. Potential pharmacological substances, inhibitors of key enzymes in glycolipid metabolism, will be synthesized and further selected according to their efficacy to affect the composition of lipid rafts in cultured neurons and the mouse models. Combinations of lipidomic and transriptomic approaches will be used to select critical signaling pathways which would be tracked down to epigenetic changes.  Genetically, environmentally and pharmacologically introduced changes in lipid rafts would give insight in their function and enable development of drugs for fine tuning of processes like stress responses and regeneration.]]></summary_en></project><project>
<id>2841</id><title_hr><![CDATA[Uloga nekodirajućih RNA u regulaciji latencije herpes simplex virusa 1]]></title_hr><title_en><![CDATA[Roles of non-coding RNAs in regulation of herpes simplex virus 1 latency]]></title_en><user_id>43</user_id><user_firstLast_name>Igor Jurak</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2014-09</proposal_call><code>IP-2014-09-8790</code><acronim><![CDATA[ON-OFF-IJ]]></acronim><duration>01.05.2015 - 30.09.2019</duration><status>Završio</status><financ_value>132.688,02 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Biologija, </scie_field_hr><scie_field_en>Biology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Fakultet biotehnologije i razvoja lijekova]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Biotechnology and Drug Development]]></institution_en><team_members_id>894, 858, 19184, 17801, 19177, 17845, </team_members_id><team_members_names><![CDATA[Marko Hohšteter, Hackenberg Michael, Maja Cokarić Brdovčak, Marina Matešić, Andreja Zubković, Maja Badurina, ]]></team_members_names><keywords_hr><![CDATA[mikroRNA, miRNA, virus, latencija, herpesvirus, herpes simplex, regulacija gena]]></keywords_hr><keywords_en><![CDATA[microRNA, miRNA, virus, latency, herpesvirus, herpes simplex, gene regulation, ]]></keywords_en><summary_hr><![CDATA[Herpes simplex virus 1 (HSV - 1) je važan patogen ljudi koji uzrokuje razna oboljenja, međutim usprkos  intenzivnim istraživanjima i velikom broju iznimnih otkrića, mnogi temeljni aspekti HSV - 1 biologije su nepoznati. Nedavnim tehničkim postignućima koja su omogućila analize  transkriptoma, postalo jasno da nekodirajuće RNA (ncRNA), koje između ostalih uključuju i miRNAs i duge ncRANs ( lncRNA ), imaju vrlo važnu ulogu u regulaciji genske aktivnosti životinja, biljaka i virusa. Naša grupa je otkrila brojne HSV -1 eksprimirane miRNA, no njihova funkcija je uglavnom nepoznata. S druge strane, već duže je poznato nekoliko HSV - 1 kodiranih lncRNAs, uključujući i intenzivno proučavan tzv. eng. latency associated transcript (LAT), glavni marker HSV - 1 latencije; ali i njihova funkcija je slabo poznata i uglavnom neistražena. Naša je hipoteza da ncRNAs imaju središnju ulogu u replikaciji ovog virusa i uspostavi latencije, posebice u regulaciji prijelaza iz latencije u litičku fazu (i.e. latentnog/litičkog prekidača). U našim nastojanjima odrediti ćemo nekodirajući transkriptom HSV-1 te odgonetnuti ulogu ncRNA u regulaciji genske aktivnosti tjekom litičke i latente faze HSV-1. Naše hipoteze temeljimo na preliminarnim podacima istraživanja funkcije miR-H1 i miR-H6, miRNA virusa koje su obilno izražena tijekom litičke i /ili latentne infekcije. U prethodnom istraživanju smo generirali virusnu mutantu koja ne eksprimira miRH1 i –H6 i preliminarni rezultati ukazuju na smanjenje patogenosti i smanjenu sposobnosti reaktivacije. U daljenjm radu ćemo uz pomoć bioinformatike i najsuvremenijih tehnika molekularne biologije utvrditi ciljne molekule ovih i drugih miRNAs , te  odrediti njihovu ulogu u infekciji. Osim toga , kako bi omogućili primjenu visoko-protočnih tehnologija u proučavanju latencije, uspostaviti ćemo in vitro model HSV-1 latencije; koji temeljimo na našim prethodnim i preliminarnim istraživanjima u kojima smo karakterizirali ekspresiju HSV - 1 miRNAs u nekoliko takvih modela. Ovaj pristup također će nam omogućiti osjetljivo testiranje tzv. latentnog/litičkog prekidača i biokemijski pristup u proučavanju interakcije ncRNA-protein.]]></summary_hr><summary_en><![CDATA[Herpes simplex virus 1 (HSV-1) is an important human pathogen that causes a variety of diseases. However, in spite of intensive studies and remarkable discoveries, many fundamental aspects of the HSV-1 biology are unknown. Recently, with expansion of transcripome analyses, it become apparent that non-coding RNAs (ncRNA), including miRNAs and long ncRANs (lncRNA), have immense role in regulation of genes of animals, plants and viruses. We have discovered numerous miRNAs expressed by HSV-1, functions of which are mostly unknown. On the other hand, a few HSV-1 encoded lncRNAs have been discovered many years ago, including intensively studied latency associated transcript (LAT), but function of these remains largely elusive and not investigated. We hypothesize that miRNAs and other ncRNAs have a central role in virus gene regulation and efficient establishment of latency, particularly the control of the lytic-latent switch (reactivation from latency). We seek to determine the complete ncRNA transcriptome of HSV-1 and understand its roles in regulation of gene expression during lytic and latent HSV-1 infection. Our study is founded on preliminary data focusing on small set of miRNAs, i.e. functions of miR-H1 and miR-H6, HSV-1 miRNAs abundantly expressed during lytic infection and/or latent infection. We have generated the HSV-1 mutant with miR-H1/H6 locus deleted, and our results indicate that these miRNA are important for virus pathogenesis. Using bioinformatics and cutting-edge molecular biology techniques we will identify targets of this and other miRNAs and reveal their function in infection. Moreover, to enable high-throughput technologies in studying latency, we will establish an in vitro latency model. In preliminary attempts, we have characterized the expression of HSV-1 and host miRNAs in such models. This approach will also allow sensitive probing of the latent/lytic switch and biochemical approaches to study ncRNA-protein interactions.]]></summary_en></project><project>
<id>2848</id><title_hr><![CDATA[Tranzicija i tradicija u špilji Vlakno: Model prijelaza paleolitika u mezolitik na području Sjeverne Dalmacije]]></title_hr><title_en><![CDATA[Transition and tradition in Vlakno cave: Modelling the Palaeolithic-Mesolithic transition in Northern Dalmatia]]></title_en><user_id>499</user_id><user_firstLast_name>Dario Vujević</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2014-09</proposal_call><code>UIP-2014-09-1545</code><acronim><![CDATA[Vlakno]]></acronim><duration>01.05.2015 - 30.04.2018</duration><status>Završio</status><financ_value>40.380,91 eur</financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Arheologija, </scie_field_hr><scie_field_en>Archeology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zadru]]></institution_hr><institution_en><![CDATA[University of Zadar]]></institution_en><team_members_id>2993, 12898, 12720, 6111, 2744, </team_members_id><team_members_names><![CDATA[Barbara Cvitkušić, Mario Bodružić, Zlatko Perhoč, Mate Parica, Siniša Radović, ]]></team_members_names><keywords_hr><![CDATA[Vlakno, paleolitik, mezolitik, epigravetijen, holocen]]></keywords_hr><keywords_en><![CDATA[Vlakno, Palaeolithic, Mesolithic, Epigravettian, Holocene]]></keywords_en><summary_hr><![CDATA[Projekt „Tranzicija i tradicija u špilji Vlakno: Model prijelaza paleolitika u mezolitik na prostoru Sjeverne Dalmacije“ je nastavak interdisciplinarnih istraživanja paleolitičkog i mezolitičkog nalazišta Vlakno na Dugom otoku, kao i šireg područja samog otoka. Špilja Vlakno trenutno je jedino nalazište Sjeverne Dalmacije dostupno za proučavanje prijelaza paleolitika u mezolitik, kontinuiteta i diskontinuiteta naseljavanja prostora, kulture, te teritorijalne organizacije. Tijekom proteklih 10 godina istraživačke aktivnosti bile su inkorporirane u različite znanstvene projekte, a slijedeći cilj je dobiti dublji uvid u život i ponašanje prapovijesnih zajednica. Kombiniranjem terenskih istraživanja, kabinetskog rada i različitih analiza pokušat će se odrediti interakcija pećine s okolišem, s ciljem dobivanja podataka koji se mogu usporediti s drugim nalazištima jadranske obale. Nova istraživanja špilje Vlakno doprinijet će proučavanju gornjeg paleolitika i mezolitika Europe, na području koje je do sada bilo relativno slabo istraženo. Uz to Vlakno bi moglo poslužiti za izradu teorijskog modela prijelaza paleolitika u mezolitik, koji bi bio primjenjiv za šire područje.Predloženi projekt trebao bi obogatiti naše spoznaje o kulturi življenja i društvenim odnosima paleolitičkih i mezolitičkih zajednica. Pomoći će u definiranju načina na koji su ljudske zajednice mijenjale svoje ponašanje zbog globalnog zatopljenja, te predložiti teorijski i empirijski model prijelaza na drugačije klimatske i okolišne uvjete holocena. Projekt će pružiti važne informacije na temu naseljavanja i kretanja zajednica u jednom klimatski nestabilnom razdoblju.]]></summary_hr><summary_en><![CDATA[Project “Transition and tradition in Vlakno cave: Modelling the Palaeolithic-Mesolithic transition in Northern Dalmatia” will continue the interdisciplinary research of Palaeolithic and Mesolithic site of Vlakno on Dugi Otok. Vlakno cave is currently the only site in northern Dalmatia available for studying Palaeolithic/Mesolithic transition, continuity and discontinuity of settlement, Palaeolithic and Mesolithic culture, territorial organization, etc. Over the past 10 years research activities were incorporated in different scientific projects, but our primary objective is to get further insights into the way of life of prehistoric communities. Combination of field work, cabinet studies and analyses will be used to determine interaction of cave with environment in order to obtain data comparable with other sites on the Adriatic coast. New research of Vlakno cave will contribute new data to the study of the European Upper Palaeolithic and Mesolithic from a relatively understudied area. Also Vlakno cave could set a theoretical model of Paleolithic-Mesolithic transition, applicable to a wider area. The proposed project should significantly enrich the knowledge on the culture of living and social relations of Palaeolithic/Mesolithic communities. It will help define the ways in which humans modified their behaviour in response to global warming and sea-level rise and propose stronger theoretical and empirical model of transition to different climatic and environmental conditions of Holocene. Project will also provide important information on Adriatic human settlement and migration patterns during this climatically unstable period. ]]></summary_en></project><project>
<id>2872</id><title_hr><![CDATA[Generalizirana geometrija i simetrije]]></title_hr><title_en><![CDATA[Generalized Geometry and Symmetries]]></title_en><user_id>52</user_id><user_firstLast_name>Larisa Jonke</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2014-09</proposal_call><code>IP-2014-09-3258</code><acronim><![CDATA[GGSymm]]></acronim><duration>01.09.2015 - 30.09.2019</duration><status>Završio</status><financ_value>79.102,79 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, </scie_field_hr><scie_field_en>Physics, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>5035, 5014, 471, 22491, 24502, 25067, 25315, </team_members_id><team_members_names><![CDATA[Athanasios Chatzistavrakidis, Ivan Andrić, Danijel Jurman, Clay James Grewcoe, Fech Scen Khoo, Grgur Šimunić, Georgios Karagiannis, ]]></team_members_names><keywords_hr><![CDATA[generalizirana kompleksna geometrija, nekomutativna geometrija, baždarne teorije, matrični modeli, fuzzy prostorir]]></keywords_hr><keywords_en><![CDATA[generalized complex geometry, non-commutative geometry, gauge theory, matrix models, fuzzy spaces]]></keywords_en><summary_hr><![CDATA[Ujedinjenje Einsteinove teorije opće relativnosti s kvantnom fizikom predstavlja jedan od najvećih izazova moderne teorijske fizike. Jedna pretpostavka zajednička svim istraživačkim smjerovima usmjerenih ka razumijevanja kvantne teorije gravitacije jest  da  za  opis geometrije prostor-vremena nije dostatna  klasična slika prostor-vremena kao diferencijabilne mnogostrukosti. U okviru ovog projekta smo zainteresirani za generalizirane geometrije motivirane fizikom teorije struna; generalizirana kompleksna geometrija i nekomutativna geometrija. Naš cilj jest  bolje razumijevanje  kako spomenute ideje generalizirane geometrije   iskoristiti u generalizaciji načela simetrije. Konkretno, zainteresirani smo za proširenje baždarnog principa, ključne ideje koji se koristi u fizici za opis svih (poznatih) međudjelovanja materije, a u svjetlu ovih proširenja klasične geometrije. Želimo opisati učinke dualnosti u teoriji struna, nekomutativne baždarne teorije te  viših baždarnih teorija u okviru učinkovne teorija polja koja nam je potrebne za obavljanje pouzdanih izračuna koje je moguće eksperimentalno provjeriti. Očekujemo da će nam geometrizacija ovih poopćenih simetrija pružiti, u dugogodišnjoj perspektivi, konzistentan okvir unutar kojeg bi se mogla riješiti neka od otvorenih pitanja u kozmologiji i fizici crnih rupa.]]></summary_hr><summary_en><![CDATA[The unification of Einstein&#39;s theory of general relativity with quantum physics represents one of the greatest challenges of modern theoretical physics. A hypothesis common to all research directions aiming at understanding the quantum theory of gravity is that our description of space-time geometry has to go beyond the classical picture of space-time as a differentiable manifold.  Within this project we are interested in generalized concepts of geometry, physically motivated by string theory: generalized complex geometry and non-commutative geometry. We aim at improving our understanding on how these generalized notions of geometry could be utilized to obtain consistent extensions of symmetry principles. In particular, we are interested in extending the gauge principle, the key physical notion used to describe all (known) matter interactions, in view of the above generalizations of classical geometry. Our goal is to capture the effects of string duality symmetries, non-commutative gauge theory and higher gauge theories at the level of the effective field theory description, which is necessary in order to perform reliable calculations and yield experimentally testable predictions. We expect that geometrizing these generalized symmetries would provide us, as a long-term perspective, with a consistent framework within which one could address open issues in cosmology and black-hole physics.]]></summary_en></project><project>
<id>2873</id><title_hr><![CDATA[Supramolekulska kontrola fotokemijskih reakcija eliminacije]]></title_hr><title_en><![CDATA[Supramolecular control of photoeliminations]]></title_en><user_id>376</user_id><user_firstLast_name>Nikola Basaric</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2014-09</proposal_call><code>IP-2014-09-6312</code><acronim><![CDATA[SupraPhotoE]]></acronim><duration>01.06.2015 - 31.08.2019</duration><status>Završio</status><financ_value>122.370,43 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, </scie_field_hr><scie_field_en>Chemistry, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>698, 3215, 3336, 3493, 3001, 566, 647, 1205, 20718, 22526, 24377, </team_members_id><team_members_names><![CDATA[Kata Majerski, Marija Alešković, Margareta  Sohora, Đani Škalamera, Leo Mandić, Ivana Antol, Lidija Uzelac, Iva Dzeba, Matija Sambol, Antonija Husak, Katarina Zlatić, ]]></team_members_names><keywords_hr><![CDATA[fotokemija, supramolekulska kemija, karbeni, policikličke molekule, ftalimidi, kinon-metidi,]]></keywords_hr><keywords_en><![CDATA[photochemistry, supramolecular chemistry, carbenes, polycyclic molecules, phthalimides, quinone methides]]></keywords_en><summary_hr><![CDATA[Dinamika supramolekulskih sustava omogućava kontrolu fotokemijske reaktivnosti i otvara mogućnosti za reakcije koje se konvencionalnim postupcima sinteze, termičkim reakcijama u izotropnoj otopini ne mogu provesti. Glavna strategija predloženog projekta je primijeniti različite supramolekulske sustave za kontrolu fotokemijske reaktivnosti. Očekuje se da će predloženo istraživanjo povećati fundamentalna znanja iz supramolekulske kemije, fotofizike i fotokemije policikličkih molekula u izotropnim medijima i supramolekulskim kompleksima. Istraživanje će biti usmjereno na tri reakcije fotoeliminacije: eliminaciju dušika iz diazirina i diazo prekursora uz nastajanje karbena, fotodekarboksilaciju različitih derivata aktiviranih s ftalimidnim kromoforom i fotodehidrataciju i deaminaciju kojom nastaju kinon-metidni intermedijeri. Aspekti kojima ćemo se baviti su učinak molekulske geometrije na reaktivnost i konstantu stabilnosti inkluzijskih kompleksa, kao i utjecaj kompleksiranja na fotofizička svojstva različitih kromofora, učinkovitost fotokemijskih reakcija i raspodjelu produkata. U vezi s predloženim istraživanjem bit će neophodno provesti sintezu velikog broja molekula, dobro definirane i u nekim slučajevima i iznimno složene strukture, što će sigurno zahtijevati značajne inovacije u sintetskoj metodologiji i razvoju postojećih tehnika. Znanstveni ciljevi projekta će ići dalje od trenutnih spoznaja kroz potragu za bio-medicinskim primjenama. Nizu spojeva će biti ispitana antiproliferativna aktivnost, pri čemu će se odrediti &#39;&#39;lead&#39;&#39; spojevi za daljnja istraživanja i potencijalni razvoj liječenja raka uz minimalne nuspojave.]]></summary_hr><summary_en><![CDATA[Dynamics of the supramolecular systems facilitates control of the photochemical reactivity and opens opportunities for reactions which cannot be conducted by conventional synthetic methods, in the thermal reactions in isotropic solution. The main strategy of the proposed project is to apply different supramolecular systems to control photochemical reactivity. The proposed research should increase the fundamental knowledge in supramolecular chemistry, photophysics and photochemistry of the polycyclic molecules in isotropic media and the supramolecular complexes. The research will be focused on three photoelimination reactions: extrusion of nitrogen from diazirines and diazo precursors (giving carbenes), photodecarboxylation of different derivatives activated by phthalimides, and photodehydration and photodeamination giving quinone methide intermediates. The aspects which we will address include the effects of molecular geometry on reactivity and stability constants of the inclusion complexes, as well as influence of the complexation on the photophysical properties of different chromophores, efficiency of the photochemical reactions and product distribution. In connection with the proposed investigations it will be necessary to synthesize a large number of well defined and in some cases extremely complex molecules which will certainly ask for substantial innovations in the synthetic methodology and development of the existing techniques. The scientific goals of the project will go beyond the state of the art and search for bio-medical applications. A series of compounds will be screened for antiproliferative activity, providing lead molecules for further research and potential development of cancer treatment with minimal side effects.]]></summary_en></project><project>
<id>2875</id><title_hr><![CDATA[Uloga oksidativnog stresa i opiorfina u temporomandibularnim poremećajima]]></title_hr><title_en><![CDATA[The role of oxidative stress and opiorphin in temporomandibular disorders  ]]></title_en><user_id>612</user_id><user_firstLast_name>Iva Alajbeg</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2014-09</proposal_call><code>IP-2014-09-3070</code><acronim><![CDATA[ROStrO-TMD]]></acronim><duration>01.10.2015 - 30.09.2019</duration><status>Završio</status><financ_value>115.896,87 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Dentalna medicina, Temeljne medicinske znanosti, Kliničke medicinske znanosti, </scie_field_hr><scie_field_en>Dental medicine, Basic Medical Sciences, Clinical sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Stomatološki fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Dentistry]]></institution_en><team_members_id>6409, 6340, 5987, 3288, 4284, 3378, 5175, 6162, 21042, 24296, </team_members_id><team_members_names><![CDATA[Tomislav Badel, Dubravka Knezović Zlatarić, Ivan Alajbeg, Dunja Rogić, Dijana Zadravec, Lea Vuletić, Ana Andabak Rogulj, Maja Sabalić, Ema Vrbanović, Ivana Lapić, ]]></team_members_names><keywords_hr><![CDATA[temporomandibularni poremećaji, oksidativni stres, opiorfin, orofacijalna bol, ELISA, HPLC MS, slina]]></keywords_hr><keywords_en><![CDATA[temporomandibular disorders, oxidative stress,  opiorphin, orofacial pain, ELISA, HPLC MS, saliva]]></keywords_en><summary_hr><![CDATA[Temporomandibularni poremećaji (TMP) kronični su bolni poremećaji koji zahvaćaju čeljusni zglob, žvačne mišiće i okolna tkiva, s prevalencijom u populaciji od 3,6 do 7%. Patološki supstrat uglavnom izostaje, a uzrok je često nepoznat. Psihološki i mehanički stresni čimbenici mogu doprinijeti nastanku oksidativnog stresa (OS) i rezultirati TMP-om.Cilj je kvantificirati markere OS, totalni antioksidativni kapacitet (TAK) te nedavno izolirani endogeni peptid opiorfin (OP) u slini pacijenata s TMP-om i usporediti ih s kontrolnom skupinom. Kako kronična izloženost stresu može uzrokovati hiperalgeziju koja nastaje kao posljedica odgovora na stres u hipotalamičko-hipofizno-adrenalnoj (HHA) osi, cilj je istražiti ovaj mehanizam uspoređujući OP i markere OS s razinom salivarnog kortizola (SK).Hipoteze: OS ima ulogu u nastanku i održavanju TMP-a, stoga će markeri OS u slini rasti i/ili će se TAK smanjiti; opiorfin utječe na orofacijalne bolne sindrome kao što je TMP i njegove vrijednosti u slini će se razlikovati između bolesnika s TMP-om i kontrole. Poremećena HHA osovina je u podlozi povećanog OS i promjena razina OP u bolesnika s TMP-om.U 50 bolesnika s TMP-om (dijagnosticiranih pomoću kriterija i MRI nalaza) i 50 kontrolnih ispitanika sakupit će se slina. Za određivanje markera OS koristit će se ELISA sa spektrofotometrijom. Razine OP mjerit će se HPLC-MS/MS metodom koju smo sami razvili. Za određivanje SK koristit će se elektrokemiluminiscentna imunokemijska metoda s prethodnom ekstrakcijom.Pacijenti s TMP-om će biti randomizirani u 2 skupine (1:stabilizacijska udlaga + placebo tablete; 2:placebo udlaga + 1g vitamina C). Mjerenja će se ponoviti nakon 3 i 6 mjeseci. Praćenje OP, OS markera i SK tijekom tog razdoblja će, ovisno o promjenama simptoma TMP-a, dodatno rasvijetliti predloženi podliježeći mehanizam. Novi pristup u objašnjavanja neuroendokrinih mehanizama u TMP-u i uporaba sline kao neinvazivno pristupačne dijagnostičke tekućine predstavlja značajan napredak. ]]></summary_hr><summary_en><![CDATA[Temporomandibular disorders (TMD) are chronic painful conditions involving joints, masticatory muscles and associated tissues that affect 3.6-7% of the population. Observable pathology is mostly absent, and the cause is unknown. Psychological and mechanical stress factors could contribute to oxidative stress (OS) and lead to TMD. Aims are to quantify salivary OS markers and total antioxidant capacity (TAC) and to quantify recently isolated endogenous peptide opiorphin (OP) in saliva of TMD patients and compare them to controls. As chronic exposure to stress may cause hyperalgesia as a result of the stress response in the hypothalamic-pituitary-adrenal (HPA) axis, aim is to test this as an underlying mechanism by correlating OP and OS markers to salivary cortisol (SC) levels. Hypotheses: OS has a role in TMD onset and maintenance, thus salivary markers of OS will increase and/or TAC will decrease; OP influences orofacial pain syndromes, such as TMD, and its salivary level will differ between TMD patients and controls. Disbalanced HPA axis underlies the increase of OS and OP level changes in TMD patients.Saliva of 50 TMD patients (diagnosed by validated diagnostic criteria and MRI) and 50 controls will be collected. OS markers will be assessed by ELISA with spectrophotometric detection and by spectrophotometric reagent kits. OP levels will be measured by HPLC-MS/MS method, developed by team members. The electrochemiluminescence immunoassay ECLIA will be used for measuring SC.TMD patients will be randomized in 2 treatment groups (1:stabilization splint + placebo pills; 2:placebo splint + 1g of vitamin C). Measurements will be repeated after 3 and 6 months of treatment. Monitoring of OP, OS markers and SC during that period will, in relation to TMD symptoms changes, further elucidate underlying proposed mechanism.Novel approach to understanding neuroendocrine mechanisms in TMD and use of saliva as non-invasively available biofluid represent significant advances.]]></summary_en></project><project>
<id>2877</id><title_hr><![CDATA[Utjecaj magnetske anizotropije na kvantne spinske sustave]]></title_hr><title_en><![CDATA[Influence of Magnetic Anisotropy on Quantum Spin Systems]]></title_en><user_id>11197</user_id><user_firstLast_name>Mirta Herak</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2014-09</proposal_call><code>UIP-2014-09-9775</code><acronim><![CDATA[IMAQSS]]></acronim><duration>01.06.2015 - 15.09.2018</duration><status>Završio</status><financ_value>99.542,11 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, Kemija, </scie_field_hr><scie_field_en>Physics, Chemistry, </scie_field_en><institution_hr><![CDATA[Institut za fiziku]]></institution_hr><institution_en><![CDATA[Institute of Physics in Zagreb]]></institution_en><team_members_id>2647, 12486, 21233, 2873, </team_members_id><team_members_names><![CDATA[Dijana Žilić, Ivana Levatić, Martina Dragičević, Nikolina Novosel, ]]></team_members_names><keywords_hr><![CDATA[Kvantni spinski sustavi, niskodimenzionalni magneti, magnetska anizotropija, torque magnetometrija, elektronska spinska rezonancija]]></keywords_hr><keywords_en><![CDATA[Quantum spin systems, low-dimensional magnets, magnetic anisotropy, torque magnetometry, esr spectroscopy]]></keywords_en><summary_hr><![CDATA[Proučavanje magnetskih materijala donijelo nam je razumijevanje mnogih fizikalnih pojava te doprinijelo razvoju novih tehnologija. Magnetizam je kvantna pojava koja dolazi od interakcija superizmjene među magnetskim momentima u materijalu. Razumijevanje utjecaja tih interakcija na formiranje materijala sa specifičnim magnetskim svojstvima jedan je od glavnih problema u znanosti o materijalima. U niskodimenzionalnim kvantnim spinskim sustavima interakcije među spinovima su često opisane izotropnim Heisenbergovim hamiltonijanom. Eksperimentalni rezultati ukazuju na važnost slabih anizotropnih interakcija te zahtijevaju nova teorijska istraživanja. Te interakcije induciraju nove zanimljive pojave s velikim potencijalom za primjenu te je nalaženje novih metoda osjetljivih na njihovu detekciju od velike važnosti.Cilj ovog projekta je eksperimentalno istraživanje utjecaja magnetske anizotropije na odabrane kvantne spinske sustave kombinacijom dviju iznimno osjetljivih tehnika: torque magnetometrije i spektroskopske metode elektronske spinske rezonancije (ESR). Istraživat ćemo uzorke čiji magnetizam dolazi od spinova S=1/2, a koji se mogu klasificirati kao male spinske nakupine, kvazi-jednodimenzionalni Heisenbergovi antiferomagneti i/ili magnetoelektrici. Kombinacija spomenutih tehnika dat će novu metodologiju za istraživanje utjecaja magnetske anizotropije na kvantne spinske sustave i druge magnetske materijale te doprinijeti razumijevanju pojava induciranih magnetskom anizotropijom.U ovom projektu ostvarit će se suradnja između fizičara i kemičara sa svrhom sinteze novih visokokvalitetnih magnetskih materijala. Istraživanja će biti fokusirana na te materijale i na uzorke dobivene iz inozemnih ekspertnih laboratorija. Glavni cilj ovog projekta je formiranje nove istraživačke grupe s ekspertizom u istraživanju pojava induciranih anizotropijom u novim magnetskim materijalima.]]></summary_hr><summary_en><![CDATA[Study of magnetic materials provides us with understanding many of physical phenomena and continues to provide us with new technologies. Magnetism is a quantum phenomenon emerging from the superexchange interactions between magnetic moments in the material. Understanding how these interactions bring forth a material with specific magnetic properties is one of the key questions in materials science. In low-dimensional quantum spin systems the interactions between the spins are often described by the isotropic Heisenberg Hamiltonian. The importance of weak anisotropic interactions emerges from experiments and requires new theoretical treatments. These interactions are found to induce new interesting phenomena with great potential for applications in emerging technologies. Exploiting new methods sensitive to these interactions is thus crucial. Aim of this project is to experimentally investigate the influence of magnetic anisotropy on chosen quantum spin systems by combining two highly sensitive techniques: torque magnetometry and electron spin resonance (ESR) spectroscopy. Our study is focused on samples with magnetism coming from electron spin S=1/2, which can be classified as weakly interacting small spin clusters, quasi one-dimensional Heisenberg antiferromagnets and/or magnetoelectrics. The combination of mentioned techniques allows a new methodology for investigation of the influence of magnetic anisotropy on quantum spin systems and other magnetic materials and will provide important input in understanding of anisotropy induced phenomena.Within this project a collaboration between physicists and a chemist will be established with the purpose of synthesising new high-quality magnetic materials. Our study will focus on these materials, and on samples synthesized in expert laboratories abroad. The main aim of this project is to form a new independent research group highly qualified to investigate the anisotropy induced phenomena in new promising magnetic materials.]]></summary_en></project><project>
<id>2881</id><title_hr><![CDATA[Istraživanje bioaktivnih spojeva iz dalmatinskog bilja: njihov antioksidacijski karakter i  utjecaj na enzimsku inhibiciju i zdravlje]]></title_hr><title_en><![CDATA[Investigation of bioactive compounds from Dalmatian plants: their antioxidant, enzyme inhibition and health properties]]></title_en><user_id>11165</user_id><user_firstLast_name>Mladen Miloš</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2014-09</proposal_call><code>IP-2014-09-6897</code><acronim><![CDATA[BioActCom]]></acronim><duration>01.09.2015 - 31.08.2019</duration><status>Završio</status><financ_value>104.851,02 eur</financ_value><scie_area_hr>Prirodne znanosti, Biotehničke znanosti, Biomedicina i zdravstvo, </scie_area_hr><scie_area_en>Natural sciences, Biotechnical sciences, Biomedicine and health sciences, </scie_area_en><scie_field_hr>Kemija, Biologija, Farmacija, Prehrambena tehnologija, Nutricionizam, </scie_field_hr><scie_field_en>Chemistry, Biology, Pharmaceutical sciences, Food technology, Nutrition, </scie_field_en><institution_hr><![CDATA[Sveučilište u Splitu, Kemijsko-tehnološki fakultet]]></institution_hr><institution_en><![CDATA[University of Split, Faculty of Chemistry and Technology]]></institution_en><team_members_id>5297, 11213, 4634, 1227, 250, 100, 3823, 11269, 11267, 11168, 11169, </team_members_id><team_members_names><![CDATA[Višnja Katalinić, Olivera Politeo, Mila Radan, Vida Šimat, Ivana Generalić Mekinić, Franko Burčul, Danijela Skroza, Ivana Carev, Maja Marasović, Safija Herenda, Jelena Ostojić, ]]></team_members_names><keywords_hr><![CDATA[bioaktivni spojevi, inhibitori enzima, antioksidansi, oksidacijski stres, dalmatinsko bilje]]></keywords_hr><keywords_en><![CDATA[bioactive compounds, enzyme inhibitors, antioxidants, oxidative stress, Dalmatian plants]]></keywords_en><summary_hr><![CDATA[ Reaktivni kisikovi spojevi (ROS), koji u  živim stanicama  nastaju tijekom prirodnih procesa aerobnog metabolizma, mogu znatno oštetiti vitalne makromolekule i promijeniti njihove  funkcije. Kao rezultat oksidacijskog stresa i inhibicije pojedinih enzima, povećana je mogućnost nastanka kroničnih bolesti kao što su rak, ateroskleroza, neurodegenerativne bolesti, dijabetes itd.  U živim organizmima razvijen je visoko sofisticirani i složeni sustav antioksidacijske zaštite, koji interaktivno i sinergijski neutralizira loš utjecaj ROS spojeva. Predloženi projekt treba skrenuti pozornost na činjenicu da dalmatinsko samoniklo bilje obiluje  biološki aktivnim spojevima koje bi se moglo koristiti za prevenciju oksidacijskog stresa i liječenje različitih oboljenja. Identifikacija novih antioksidansa i inhibitora enzimskih aktivnosti  mogla naći primjenu u prehrambenoj i farmaceutskoj industriji za pripremu zdrave hrane i prirodnih lijekova za sprječavanje štetnih oksidacijskih procesa.]]></summary_hr><summary_en><![CDATA[Reactive oxygen species (ROS), which are generated during the natural process of aerobic metabolism in living cells, can significantly damage their vital macromolecules and change functions. As a result of oxidative stress and inhibition of certain enzyme activities, it has increased the possibility of occurrence of chronic diseases such as cancers, atherosclerosis,  neurodegenerative diseases, diabetes, etc.  To protect the cells and organs of the body against ROS, human organisms have evolved a highly sophisticated and complex antioxidant protection system which involves a variety of components that interactively and synergistically could neutralize their bad influence.  Identification of new antioxidant and inhibitor of the enzyme activities from Dalmatian plants could find application in the food and pharmaceutical industry for preparing healthy foods and natural remedies to prevent harmful oxidation processes.]]></summary_en></project><project>
<id>2886</id><title_hr><![CDATA[Molekularna, epidemiolološka i klinička obilježja zaraze HIV-om u Hrvatskoj]]></title_hr><title_en><![CDATA[Molecular, epidemiological and clinical features of HIV infection in Croatia]]></title_en><user_id>1084</user_id><user_firstLast_name>Josip Begovac</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2014-09</proposal_call><code>IP-2014-09-4461</code><acronim><![CDATA[MEKHH/MECHC]]></acronim><duration>01.10.2015 - 31.12.2019</duration><status>Završio</status><financ_value>126.750,28 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Kliničke medicinske znanosti, Temeljne medicinske znanosti, Javno zdravstvo i zdravstvena zaštita, </scie_field_hr><scie_field_en>Clinical sciences, Basic Medical Sciences, Public health and health services, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb School of Medicine]]></institution_en><team_members_id>1082, 12514, 1093, 4080, 12478, 1161, 3952, 3951, </team_members_id><team_members_names><![CDATA[Klaudija Višković, George Rutherford, Šime  Zekan, Snježana Židovec Lepej, Ana Planinić, MARTA PEROVIĆ MIHANOVIĆ, Lana Gorenec, Ivana Grgić, ]]></team_members_names><keywords_hr><![CDATA[HIV, AIDS, supklinička ateroskleroza, podtipovi HIV-a, rezistancija, antiretrovirusni lijekovi, preživljenje]]></keywords_hr><keywords_en><![CDATA[HIV. AIDS, subclinical atherosclerosis, HIV subtypes, resistance, antiretrovirals, survival]]></keywords_en><summary_hr><![CDATA[Hrvatska ima centraliziranu skrb za osobe zaražene HIV-om, svi bolesnici se liječe u Klinici za infektivne bolesti u Zagrebu. Opći cilj projekta je nastaviti dugotrajno prikupljati kliničke, molekularne, laboratorijske i terapijske podatke u skupini bolesnika zaraženih HIV-om iz Hrvatske te: (1) procijeniti čimbenike u svezi s kliničkim, imunološkim i virusološkim tijekom zaraze HIV-om i (2) nastaviti razvijati sustav molekularnog nadzora uz definiranje promejna koje se tijekom vremena događaju u zarazi HIV-om u Hrvatskoj. Opći istraživanja uključuje prospektivno istraživanje demografskih, kliničkih, terapijskih, virusoloških i laboratorijskih podatke u osoba zaraženih HIV-om u Hrvatskoj, u svrhu određivanja dugotrajnog virusološkog, imunološkog i kliničkog ishoda kao i trendove u molekularnoj epidemiologiji zaraze HIV-om. Specifični ciljevi istraživanja uključuju također: procjenu nazočnosti supkliničke ateroskleroze u bolesnika zaraženih HIV-om koji primaju ART te ispitanika koji nisu zaraženi HIV-om, analizirati učinak prehtrambenih navika, posebno mediteranske prehrane na supkliničku aterosklerozu, odrediti učestalost subtipova HIV-a u novodijagnosticiranih bolesnika koji su se uključili u kliničku skrb u razdoblju od 2014 do 2017.g., analizirati transmisijske klastere subtipa B i non-B subtipova HIV-a, te odrediti prevalenciju i obrasce mutacija povezanih s primarnom rezistencijom HIV-a na lijekove. U istraživanje će se uključiti sve osobe koje se liječe u KIB, a dale su pismenu privolu za istraživanje. Uključiti će se osobe koje su bile u skrbi u razdoblju 1997 do 2017. Procjenjuje se da će ukupno 700-800 osoba biti uključeno u analize. Očekujemo da će rezultati ovog projekta doprinijeti unaprjeđivanju kvalitete skrbi bolesnika zaraženih HIV-om kao i razvoju strategija uspješnije prevencije zaraze HIV-om.]]></summary_hr><summary_en><![CDATA[Croatia as a centralized system of care and all HIV infected persons are treated at the University Hospital of Infectious Diseases (UHID) in Zagreb. ln general terms, the objective of the project s to continue a long-term, prospective collection of biomolecular, clinical, laboratory and therapeutic data on a cohort of HIV infected patients from Croatia in order to (1) assess the factors associated with the clinical, immunological and virological course of HIV infection and (2) continue to provide and develop a molecular surveillance system to describe temporal changes of HIV-infection in in Croatia. The primary aim is to determine the long-term virological, immunological and clinical outcome as well as trends in the molecular epidemiology of HIV infection. We will also specifically address issues such as: subclinical atherosclerosis in both HIV-infected patients taking ART and non-HIV-infected participants; the influence of food habits, specifically adherence to the Mediterranean diet on subclinical atherosclerosis; the frequency of HIV subtypes among newly-diagnosed patients entering clinical care in the period 2014-2017; transmission clusters of B and non-B subtypes; prevalence and patterns of transmitted drug resistance (TDR) to different classes of antiretroviral drug resistance in newly-diagnosed HIV-infected persons in the period 2014-2017 with the impact of transmission clusters on the prevalence of TDR. The study population will include all patients in care at UHID who provided written consent. Patient eligible for analysis were or will be seen in care at UHID from 1997 to 2017. It is estimated that a total of about 700-800 will be included into the analyses. The results of this project are expected to significantly contribute to the improvement of HIV clinical care as well as to the development of improved strategies for prevention of HIV infection.]]></summary_en></project><project>
<id>2887</id><title_hr><![CDATA[Životne strategije fitoplanktona u sjevernom Jadranu]]></title_hr><title_en><![CDATA[Phytoplankton lifestrategies in the northern Adriatic]]></title_en><user_id>3476</user_id><user_firstLast_name>Martin Pfannkuchen</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2014-09</proposal_call><code>UIP-2014-09-6563</code><acronim><![CDATA[P-limit]]></acronim><duration>30.09.2015 - 29.09.2018</duration><status>Završio</status><financ_value>132.709,54 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Biologija, Kemija, </scie_field_hr><scie_field_en>Biology, Chemistry, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>465, 547, 4424, 5284, 81, 543, 390, </team_members_id><team_members_names><![CDATA[Ingrid Ivančić, Emina Pustijanac, Daniela Maric Pfannkuchen, Grozdan Kušpilić, Blaženka Gašparović, Mirta Smodlaka Tanković, Ana Baričević, ]]></team_members_names><keywords_hr><![CDATA[Fitoplankton, aktivnost alkalina fosfatasa, sjeverni jadran, fosfat limitacija, životna strategija]]></keywords_hr><keywords_en><![CDATA[Phytoplankton, alkaline phosphatase activity, northern Adriatic, phosphate limitation, life strategy]]></keywords_en><summary_hr><![CDATA[U plitkim morima jednostanični organizmi su ključni za funkcioniranje ekosustava. Budući da je rast tih organizama uglavnom ograničen dostupnošću anorganskog dušika i fosfora, indukcijom ekstracelularnih enzima oni mogu koristiti organsku tvar kao izvor tih elementa. Mjerenja ukupne enzimatske aktivnosti su dobar pokazatelj metaboličke aktivnosti planktnonskih zajednica. Međutim da bi se shvatilo funkcioniranje ekosustava u cijelini, te kako planktonske zajednice reagiraju na prirodne promjene i antropogeni pritisak potrebno je poznavati odgovore na razini pojedine vrste unutar zajednice. Ta saznanja bi značajno doprinijela razumijevanju kako pojedine vrste utječu na funkcioniranje zajednice. Do sada takva detaljna istraživanja nisu sistematski provedena. Zbog neuravnoteženog slatkovodnog unosa hranjivih soli područje je uglavnom P limitirano. Stoga fitoplankton na tom području mora razviti strategije snalaženja da bi uspješno kompetirao za za taj element. Naša preliminarna istraživanja su pokazala da mikrofitoplankton može razviti čitav niz mehanizama prilagodbe da bi uspijevao u izrazito promjenjivoj dostupnosti hranjivih soli i uglavnom P limitiranim uvjetima. Cilj ovog projekta bio bi shvatiti metabolizam na nivou vrste te istražiti strategije koje omogućavaju najvažnijim vrstama da uspjevaju u kompleksnim uvjetima okoline. SJ je podesan za takva istraživanja jer na tom području postoje dugoročni podaci o oceanografskim i trofičkim uvjetima. Istraživanja bi bila usredotočena na mikrofitoplankton budući da je po biomasi to dominantna grupa fitoplanktonske zajednice. Osim toga njegovo je taksonomsko određivanje dobro uhodano, a metode dostupne našoj istraživačkoj grupi. Skup modernih i klasičnih metoda razvijenih i kombiniranih u ovom projektu značajno će doprinijeti napretku u ekološkim istraživanjima, kao i u klasičnom sustavu praćenja ekosustava.]]></summary_hr><summary_en><![CDATA[Unicellular organisms are the driving forces in shallow pelagic ecosystem functioning. Measurement of bulk enzymatic activity in water samples is a good proxy for the metabolic activity of planktonic communities. However the basis to understand how such ecosystems function and how planktonic communities react on natural and anthropogenic changes is detailed knowledge on how each functional unit (species) of the plankton community functions. Such knowledge will allow to understand how each component (species) contributes to the bulk community functioning and more important how changes in ecological conditions will change the community structure and subsequently the ecosystems functioning. So far such detailed analyses are not systematically undertaken. In this project we will achieve species resolution in metabolic analysis and understand the respective lifestrategies that make the most prominent phytoplankton species successful competitors in the P-limited system of the northern Adriatic (NA). We chose the NA as a well investigated and understood marine shallow ecosystem. This project investigates the metabolic adaptations to P-limitation as they are the most prominent adaptation in the NA. We will concentrate our investigations on microphytoplankton as it is taxonomically well defined and accesible to our research teams expertise and range of methods and as our preliminary results show the microphytoplankton to be the dominating component of the plankton community in the NA. Our preliminary research did uncover a variety of mechanisms that allow microphytoplankton to thrive in steep ecological gradients and generally P-limited conditions. A combination of modern and classical methodologies (ecology, oceanography, cell biology, advanced microscopy, taxonomy, phylogenetic analysis, molecular biology, biochemistry) as well as a comprehensive ecological (long term) database for the region will allow us to uncover the complex set of microphytoplankton lifestrategies.]]></summary_en></project><project>
<id>2891</id><title_hr><![CDATA[Sklerokronologija kao alat za otkrivanje dugoročnih okolišnih promjena u Jadranu]]></title_hr><title_en><![CDATA[Sclerochronology as a tool for detecting long-term Adriatic environmental changes]]></title_en><user_id>667</user_id><user_firstLast_name>Melita Peharda Uljević</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2014-09</proposal_call><code>IP-2014-09-5747</code><acronim><![CDATA[SCOOL]]></acronim><duration>01.06.2015 - 31.05.2019</duration><status>Završio</status><financ_value>116.815,98 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Biologija, Geologija, Kemija, Geofizika, </scie_field_hr><scie_field_en>Biology, Geology, Chemistry, Geophysics, </scie_field_en><institution_hr><![CDATA[Institut za oceanografiju i ribarstvo]]></institution_hr><institution_en><![CDATA[Institute of Oceanography and Fisheries]]></institution_en><team_members_id>195, 829, 670, 5215, 3031, 3525, 2530, 7600, 5837, 25078, </team_members_id><team_members_names><![CDATA[Ivica Vilibić, Jadranka Šepić, Daria Ezgeta Balić, Krešimir Markulin, Žarko Kovač, Hrvoje Mihanović, Sanja Puljas, Miroslav Gacic, Ivan Župan, Hana Uvanović, ]]></team_members_names><keywords_hr><![CDATA[klimatske promjene, sklerokronologija, Bivalvia, dinamička svojstva mora, ekologija mora]]></keywords_hr><keywords_en><![CDATA[climate change, sclerochronology, Bivalvia, ocean dynamics, marine ecology]]></keywords_en><summary_hr><![CDATA[Klimatske promjene predstavljaju rastući problem sa aspekta okoliša, znanosti kao gospodarstva. Iako smo svjesni određenih promjena koje se događaju naše poznavanje njihovog porijekla i posljedica još uvijek je jako ograničeno. Dugoročni nizovi podataka su ključ za razumijevanje takvih promjena i čvrste strukture morskih organizama, uključujući ljušture školjkaša, predstavljaju važan arhiv podataka o okoliš koji potencionalno seže dekade ili čak stoljeća u prošlost. Sklerokonologija je novo interdisciplinarno područje znanosti koje omogućava dobivanje podataka o morskom okolišu iz strukturalnih elementa školjkaša i njihovog geokemijskog sastava. Takvi podatci su od velikog značaja za razumijevanje procesa na nivou ekosustava u morskom okolišu kao i njihovih odgovora na klimatske promjene.Motivacija i cilj ovog projekta jest je da primjenom recentnih sklerokronoloških metoda izgradimo kronologije za tri relativno dugo živuće vrste školjkaša (životni vijek oko pola stoljeća), koje obitavaju u istočnom Jadranu. Ciljane vrste uključuju školjkaše Glycymeris glycymeris, G. bimaculata i Callista chione. Kronologije će biti paralelno analizirane sa dugoročnim in situ podatcima kao i modeliranjem klimatoloških i oceanografskih parametara, sa ciljem kvantificiranje utjecaja okoliša na rast školjkaša. Nadalje, oceanografski podatci će se primijeniti za opisivanje dinamike oceana i procesa koji se odvijaju na višegodišnjim i dekadskim vremenskim skalama u Jadranko-Jonskom bazenu i koji su važni za rast svih morskih organizama. Projekt se razvija iz dvije nezavisne teme, sklerokronologije i fizičke oceanografije (znanosti o okolišu), koje se spajaju na interdisciplinarni način u kasnijim fazama implementacije projekta. Stoga je predloženi projekt izuzetno interdisciplinaran, dok je projektni tim transnacionalan.            ]]></summary_hr><summary_en><![CDATA[Climate change is a growing environmental, scientific as well as economic issue. However, although we are aware of certain changes our understanding of their origin and consequences is still very limited. Long-term data series are a key to this understanding and hard structures of marine organisms, including bivalve shells, present an important archive of environmental data potentially extending decades or even centuries into the past. Sclerochronology is an emerging interdisciplinary field that enables obtaining of marine environmental data from bivalve shell structural elements as well as their geochemical composition. These data are of great importance for understanding of the marine ecosystem-level process and responses to climate variability.Our motivation for the project is, by applying modern sclerochronological methods, to construct chronologies for three relatively long-lived bivalve species (longevity about half-century), living in the eastern Adriatic Sea. Target organisms include dog cockles Glycymeris glycymeris and G. bimaculata, and a smooth clam Callista chione. These chronologies will be analysed in parallel with long-term in situ and climate model oceanographic data, in order to quantify environmental effect on the bivalve growth. Further on, the oceanographic data will be used for portraying of ocean dynamics and processes that occur over interannual and decadal timescales in the Adriatic-Ionian basin and are important for growth of all marine organisms. The project will grow from two relatively independent topics, sclerochronology and ocean physical (environmental) sciences, merging them in an interdisciplinary manner in the later stage of the project execution. The project is highly interdisciplinary, while the project team is transnational. ]]></summary_en></project><project>
<id>2892</id><title_hr><![CDATA[Razvoj metodološkog okvira za rješavanje strateških problema u  visokom obrazovanju – primjer implementacije otvorenog učenja i učenja na daljinu]]></title_hr><title_en><![CDATA[Development of methodology and tools for multicriteria decision making in HE- case study of open and distant learning implementation]]></title_en><user_id>12508</user_id><user_firstLast_name>Blazenka Divjak</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2014-09</proposal_call><code>IP-2014-09-7854</code><acronim><![CDATA[HigherDecision]]></acronim><duration>01.06.2015 - 31.05.2019</duration><status>Završio</status><financ_value>77.427,50 eur</financ_value><scie_area_hr>Društvene znanosti, Prirodne znanosti, Tehničke znanosti, </scie_area_hr><scie_area_en>Social sciences, Natural sciences, Technological sciences, </scie_area_en><scie_field_hr>Informacijske znanosti, Matematika, Računarstvo, </scie_field_hr><scie_field_en>Information sciences, Mathematics, Computer sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet organizacije i informatike]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Organization and Informatics]]></institution_en><team_members_id>12509, 12516, 12523, 5642, 12531, 12521, 12527, 12583, 12591, 121, 7751, 13731, 12590, 6087, 21076, 25090, </team_members_id><team_members_names><![CDATA[Nina Begičević Ređep, Marcel Maretić, Katarina Pažur Aničić, Ivanka Đeri, Vjeran Strahonja, Nikola Kadoić, Sanjana  Buć, Valentina Đurek, Tihomir Hunjak, Maja Ćukušić, Andrina Granić, Sandra Kučina Softić, Valentina Kirinić, Ana Ćorić Samardžija, Antonia Bralic, Mišo Džeko, ]]></team_members_names><keywords_hr><![CDATA[odlučivanje, e-učenje, otvoreno učenje i učenje na daljinu, visoko obrazovanje, e-spremnost, procjena rizika, kauzalnost, AHP]]></keywords_hr><keywords_en><![CDATA[decision making, e-learning, open and distant learning, higher education, e-readiness, risk assessment, portfolio, causality, AHP]]></keywords_en><summary_hr><![CDATA[Visoko obrazovanje (VO) ima ključnu ulogu u razvoju ljudskih potencijala te u gospodarskom i društvenom razvoju. Stoga, donošenje odluka i praćenje njihove primjene u visokom obrazovanju postaje prvorazredno istraživačko i razvojno pitanje. Primarni istraživački cilj ovog projekta je razvoj cjelovite metodologije donošenja strateške odluke i praćenja njezine provedbe u VO. U svijetu se broj korisnika online edukacije rapidno povećava, a postoje i brojna izvješća koja govore o digitalnoj spremnosti te upotrebi informacijsko-komunikacijske tehnologije (IKT) u VO. Dvije osnovne komponente projekta:1. Razvoj  metodološkog okvira donošenja strateških odluka u VO i praćenje njihove provedbe. 2. Primjena, prilagodba i provjera dane metodologije na primjeru implementacije odluke o uvođenju otvorenog učenja i učenja na daljinu.Istraživanje je interdisciplinarno i povezuje društveno područje (višekriterijsko odlučivanje, IKT, strateško planiranje) i matematiku (matematičko modeliranje, kvantitativne metode u odlučivanju, kauzalne modele i teoriju grafova). Istraživanje rješavanja strateških problema provodimo kroz ciklus strateškog odlučivanja u četiri faze: (1) prepoznavanje i istraživanje problema - identificirat će se i unaprijediti metodologije kao što su procjena spremnosti i difuzija inovacija.(2) razvoj metodologije odlučivanja i donošenja odluke -  istražit će se primjena i unapređenje metodologije višekriterijske analize odluka u VO.(3) provedba i praćenje strateške odluke - identificirati će se ključni faktori koji utječu na uspješnost provedbe strateške odluke i njihove međuzavisnosti i razviti model za mjerenje zrelosti i uspješnosti implementacije strateških odluka u VO.(4) evaluacija učinaka provedbe odluke -  istražit će se mogući pristupi, a posebno evaluacija upotrebom strukturalne teorije kauzalnosti. ]]></summary_hr><summary_en><![CDATA[Higher education’s (HE) key mission is to develop human potential with beneficial effects for the social and economic development. HE as a system, along with HE institutions, must be innovative and strategically managed to be able to fulfill their mission. Therefore, the decision making accompanied by evaluation of its implementation in higher education is an issue of highest priority. Primary goal of this research proposal is to develop a complete methodology for strategic decision making and the monitoring of its implementation in HE. The enrollment rate within online education has skyrocketed worldwide and there are a number of reports on e-readiness and ICT use in HE. Two basic components of the project:1. Development of methodological framework for strategic decision making in HE and monitoring of its implementation. 2. Application, adjustment and evaluation of the methodology on the example of decision implementation on e-learning and distance learning.This is an interdisciplinary project connecting Social Sciences (ICT, multicriteria decision making, strategic planning) and Mathematics (mathematical modeling, quantitative methods in decision making, structural causal models and graph theory).The research is structured as a cycle of strategic decision making with four phases:(1) Intelligence - problem identification and research, advancement of methodologies such as readiness assessment, diffusion of innovation etc.(2) Design of methodology -  design of decision making methodology and decision making, improvement of multicriteria decision analysis in HE.(3) Implementation and monitoring - research and identification of key factors that determine effectiveness of strategic decision, their correlation, design of measuring model for maturity and effectiveness of strategic decision implementation in HE(4) Evaluation - survey possible approaches and evaluation by application of J. Pearl’s structural causal models for identification of effects of strategic decision.]]></summary_en></project><project>
<id>2899</id><title_hr><![CDATA[Procesi u morskoj mikrobnoj hranidbenoj mreži u perspektivi globalnog zatopljenja]]></title_hr><title_en><![CDATA[Marine microbial food web processes in global warming perspective]]></title_en><user_id>172</user_id><user_firstLast_name>Mladen Šolić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2014-09</proposal_call><code>IP-2014-09-4143</code><acronim><![CDATA[MICROGLOB]]></acronim><duration>01.11.2015 - 31.10.2019</duration><status>Završio</status><financ_value>115.468,84 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Biologija, Kemija, </scie_field_hr><scie_field_en>Biology, Chemistry, </scie_field_en><institution_hr><![CDATA[Institut za oceanografiju i ribarstvo]]></institution_hr><institution_en><![CDATA[Institute of Oceanography and Fisheries]]></institution_en><team_members_id>203, 459, 531, 204, 437, 407, 207, </team_members_id><team_members_names><![CDATA[STEFANIJA  ŠESTANOVIĆ, Nada  Krstulović, Ana Vrdoljak, Slaven Jozić, Danijela Šantić, Marin Ordulj, Natalia Bojanić, ]]></team_members_names><keywords_hr><![CDATA[mikrobna zajednica, mikrobna hranidbena mreža, grazing, protok ugljika, globalno zatopljenje, fosfor, bakterijska respiracija, bakterijska efikasnost ]]></keywords_hr><keywords_en><![CDATA[microbial community, microbial food web, grazing, carbon flux, global warming, phosphorus, bacterial respiration, bacterial growth efficiency]]></keywords_en><summary_hr><![CDATA[Mikrobna zajednica uključuje jednostanične organizme koji pokrivaju široki veličinski raspon (od 0.02 do 200 µm) i s obzirom na trofički status uključuju autotrofne, heterotrofne i miksotrofne organizme. Ova je zajednica odgovorna za više od 50% primarne proizvodnje i proizvodnje kisika na Zemlji i ključni je pokretač biogeokemijskih ciklusa koji su ključni za ukupnu produktivnost mora. S obzirom na te značajke, vrlo je važno znati kako ova zajednica odgovara na poremećaje u morskom okolišu. Tijekom ovog projekta istraživat će se struktura mikrobne zajednice i mikrobna hranidbena mreža, te njeni kvantitativni, kvalitativni (strukturni) i funkcionalni odgovori na prirodne i antropogene promjene u morskom okolišu, te će se pokušati detektirati potencijalni pokazatelji tih promjena. U fokusu projekta biti će traženje odgovora na pitanje koje promjene u strukturi i funkcioniranju morske mikrobne hranidbene mreže u uvjetima globalnog zatopljenja možemo očekivati, te kako se ti utjecaji manifestiraju s obzirom na trofički status područja. Pri tome će se posebice istraživati uloga fosfora s obzirom da je Jadransko more općenito fosforom limitirano područje. Istraživanja će uključivati mjesečna terenska istraživanja koja će obuhvatiti estuarska, priobalna i otvorena područja mora, kao i laboratorijske i in situ eksperimente. Aktivnosti na Projektu odvijat će se kroz tri glavne teme: (1) Struktura mikrobne hranidbene mreže koja će biti istraživana na prostornoj (različiti morski okoliši), trofičkoj (trofički gradijent) i vremenskoj (mjesečna i međugodišnja) skali, te moguće temperaturnoj i salinitetnoj skali (usporedna analiza između prirodnih sustava s različitim temperaturnim i salinitetnim režimom), (2) Protok bakterijskog ugljika, koji uključuje eksperimente grazinga, te protok zgljika kroz mikrobnu hranidbenu mrežu, te (3) Eksperimentalni utjecaj porasta temperature i koncentracije fosfora na strukturu i funkcije mikrobne hranidbene mreže.]]></summary_hr><summary_en><![CDATA[Microbial community includes single-celled organisms that cover a wide size range (from 0.02 to 200 µm) and includes autotrophic, heterotrophic and mixotrophic organisms. This community is responsible for more than 50% of the primary production and oxygen production on Earth and are essential driving forces for biogeochemical cycles with established impacts on overall marine productivity. With respect to these properties it is very important to know how the community responds to disturbances and environmental changes. This project will study the structure of microbial community and microbial food web, as well as its quantitative, qualitative (structural) and functional responses to natural and man-induced changes in marine environment and will try to detect potential indicators of these changes. The main focus of the project will be to study what changes in the structure and functioning of marine microbial food web in terms of global warming we can expect, and how these influences are manifested with regard to the trophic status of the area. The role of phosphorus will be particularly studied with regard to the fact that Adriatic Sea is generally phosphorus limited area. Research will consist of monthly field sampling that will include estuary, coastal and open sea areas, as well as laboratory and in situ experiments. Project activities will be carried out through three main topics: (1) Structure of microbial food web on spatial (different marine environments), trophic (trophic gradient) and temporal (intra- and inter-annual) scales, and possibly temperature and salinity scales (cross comparisons between natural systems under different temperature and salinity regimes); (2) Bacterial carbon flux which include grazing experiments and study of bacterial carbon flux through the microbial food web; and (3) Experimental impact of temperature increase and phosphate additions on microbial community structure and carbon flux toward the higher trophic levels.]]></summary_en></project><project>
<id>2904</id><title_hr><![CDATA[Razvoj sintetskih kimera vinove loze (Vitis vinifera L.)]]></title_hr><title_en><![CDATA[Development of grapevine (Vitis vinifera L.) synthetic chimeras ]]></title_en><user_id>11198</user_id><user_firstLast_name>Darko  Preiner</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2014-09</proposal_call><code>UIP-2014-09-8110</code><acronim><![CDATA[ChimeraVitis]]></acronim><duration>16.06.2015 - 14.09.2018</duration><status>Završio</status><financ_value>37.604,80 eur</financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Biotehnologija, Poljoprivreda, </scie_field_hr><scie_field_en>Biotechnology, Agriculture, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Agronomski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Agriculture]]></institution_en><team_members_id>13517, 13508, 13506, 4418, 13543, 13509, 3132, 24336, </team_members_id><team_members_names><![CDATA[Anita Mihovilović Bošnjak, Željko  Andabaka, Domagoj  Stupić, Silvio  Šimon, Jasminka Karoglan Kontić, Zvjezdana Marković, Edi Maletić, Iva Šikuten, ]]></team_members_names><keywords_hr><![CDATA[vinova loza, oplemenjivanje bilja, sintetske kimere, kultura biljnog tkiva, mikrosatelitski markeri]]></keywords_hr><keywords_en><![CDATA[grapevine, plant breeding, synthetic chimeras, plant tissue culture, microsatelite marc]]></keywords_en><summary_hr><![CDATA[Biljne periklinalne kimere imaju tkiva najmanje dviju različitih genotipova u različitim slojevima apikalnog meristema što ima znatan utjecaj na svojstva ovakvih biljaka. Mnoge sorte i klonovi vinove loze koje su danas značajne u proizvodnji su periklinalne kimere koje su nastale spontano zbog mutacija u jednom od slojeva apikalnog meristema (Pinot crni, sivi i meunier).  Za razliku od kimera koje su nastale mutacijama postoje i tzv. međuvrsne ili međusortne kimere koje su sastavljene od dvaju različitih genotipova koji pripadaju različitim vrstama ili sortama. Ovakve kimere mogu nastati spontano iz spojnog mjestu prilikom cijepljenja, a mogu se  ciljano stvoriti što je osnovni preduvjet za razvoj kimeralnog oplemenjivanja, kao izuzetno zanimljive, ali zapostavljene metode oplemenjivanja bilja. U predloženom projektu istraživati će se  mogućnosti dobivanja i detekcije sintetskih kimera različitih sorata vinove loze, ali i sintetskih kimera sorata vinove loze i američkih vrsta (otporne na filokseru, plamenjaću i pepelnicu). U početnoj fazi projekta istraživati će se uvjeti za uspješnu in vitro organogenezu 20 različitih genotipova (10 sorata, 5 podloga i 5 vrsta iz roda Vitis.). U slijedećoj fazi odabrati će se genotipovi koji imaju slične zahtjeve prema uvjetima  za organogenezu te će se ona nastojati inducirati iz miješanog tkiva iz najmanje triju parova odabranih genotipova. Nakon organogeneze detektirati će se biljke sa kimeralnim statusom bilo koje vrste. Identifikacija i dokazivanje kimera provesti će se kombinacijom fenotipskih markera (npr. boja epiderme) i analizom genotipa primjenom mikrosatelitskih (SSR) markera. Pozicije genotipova u slojevima staničja periklinalnih kimera provest će se genetičkim analizom (SSR) adventivnog korijena. Rezultati ovog projekta o mogućnostima razvoja sintetskih međusortnih i međuvrsnih kimera uvelike će utjecati na daljnji razvoj kimeralnog oplemenjivanja kod vinove loze.]]></summary_hr><summary_en><![CDATA[Plant periclinal chimeras have tissues of at least two different genotypes in different layers of apical meristem and this has significant influence on properties of this plants. Many grapevine cultivars and clones used in production today are actually periclinal chimeras formed by spontaneous mutation of cells in certain layer of apical meristem (i.e. Pinot noir, gris and meunier).  Many intervarietal and interspecific chimeras are also detected which are formed from two different genotypes (cultivars or species). This type of chimeras can arise spontaneously from graft tissue, but this process can also be controlled.  This is the base for development of chimeral breeding, as a very interesting but underutilized plant breeding method. In project proposal research on the possibilities of in vitro methods of development and detection of grapevine intravarietal synthetic chimeras will be performed, but also chimeras of grapevine and other Vitis species (with resistance to phyloxera, downy and powdery mildew). In the first stage of the project research on conditions for in vitro organogenesis of 20 different genotypes (10 grapevine cultivars, 5 rootstocks and 5 genotypes of  Vitis species). In next stage of the project genotypes with similar requirements for organogenesis conditions will be chosen, and organogenesis will be induced from mixed tissue of at least three pairs of genotypes. After organogenesis, detection of all chimeral plants will be performed. Identification and confirmation of chimeras will be performed using combination of phenotypic markers (i.e. color of epiderm ) and by analyzing genotypes using microsatellite marker (SSR). Position of different genotypes in cell layers of periclinal chimeras will be determined by adventive roots genotyping. Results of this research, on possibilities of grapevine synthetic chimeras development, will have a significant influence on future development of grapevine chimeral breeding.]]></summary_en></project><project>
<id>2905</id><title_hr><![CDATA[Novootkrivene cirkulirajuće izoforme BMP1  proteina kao biomarkeri i terapijski ciljevi za humane bolesti]]></title_hr><title_en><![CDATA[Newly discovered BMP1 circulating isoforms as biomarkers and therapeutic targets for human diseases]]></title_en><user_id>4108</user_id><user_firstLast_name>Lovorka Grgurević</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2014-09</proposal_call><code>UIP-2014-09-3509</code><acronim><![CDATA[BMP1-IsoFor]]></acronim><duration>01.01.2016 - 31.12.2018</duration><status>Završio</status><financ_value>132.590,09 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb School of Medicine]]></institution_en><team_members_id>13196, 13183, 6237, 13232, 3289, 13334, 1278, 965, </team_members_id><team_members_names><![CDATA[Morana Jankolija, Tatjana Bordukalo Nikšić, Vera Kufner, Ruđer Novak, Ivo  Dumić-Čule, Hermann Oppermann, Mario Matijašić, Hana Čipčić Paljetak, ]]></team_members_names><keywords_hr><![CDATA[metaloproteinaze, kronično bubrežno zatajenje, jetrena fibroza, izoforme, humanizirana protutijela]]></keywords_hr><keywords_en><![CDATA[metalloproteinases, chronic kidney disease, liver fibrosis, isoforms, humanized antibodies]]></keywords_en><summary_hr><![CDATA[Pokušali smo identificirati i karakterizirati strukturu cirkulirajućih koštanih morfogenetskih proteina (BMP) u ljudskoj plazmi i izravno ih povezati uz patološka zbivanja u određenom organu. Umjesto toga, slučajno smo otkrili cirkulirajuće izoforme metaloproteinaza koji su proizvod Bmp1 gena: BMP1-3 (mTld) u zdravih muškaraca i pacijenata s kroničnom bubrežnom bolešću (CKD), BMP1-4 u pacijenata s cirozom jetre (LC), BMP1-5 u pacijenata s akutnim infarktom miokarda (AMI), i BMP1-7 u oboljelih od pankreatitisa. Kasnije smo pokazali da primjena BMP1-3 proteina pogoršavaju, dok BMP1-3 poliklonsko antitijela popravljaja bubrežnu funkciju i povećava preživljenje u štakora s CKD. Dodatno, inhibicija proteina BMP1-3 te kombinacija s neutralizacijom BMP1-4 proteina poboljšava funkciju jetre i srca nakon LC, odnosno AMI. Stoga pretpostavljamo da je molekula BMP1-3 ključna u signalnom putu koji regulira fibrozu te da njegova neutralizacija može ograničiti progresiju stvaranja ožiljka. U skladu s ovim rezultatima predlažemo novi znanstveni koncept u savladavanju fibroze preko glavnog te organ-specifičnih regulatornih puteva kroz sljedeće ciljeve: 1/ proizvesti izoforme BMP1 proteina i odgovarajuća monoklonska antitijela; 2/ odrediti specifične substrate za BMP1 izoforme; 3/ razviti novi osjetljivi biološki test za mjerenje BMP1 izoformi u različitim životinjskim eksperimentalnim modelima;  4/ istražiti ulogu BMP1 izoformi u životinja sa CKD i LC. Varijabilna domena najučinkovitijih monoklonskih antitijela će biti sekvencionirana i humanizirana s ciljem terapijske primjene i potencijalnog razvitka novog dijagnostičkog markera. Ovim novim pristupom pokušava se definirati ključna ciljna molekula za zaustavljanje progresije ili poboljšanje u CKD i LC. Naša hipoteza je da modulacija ili inhibicija BMP1 izoformi predstavlja budućnost terapijskih intervencija u spriječavanju fibroze]]></summary_hr><summary_en><![CDATA[We sought to identify and characterize the structure of circulating bone morphogenetic proteins (BMPs) in the human plasma directly associated with organ specific pathology. Instead, we unexpectedly discovered circulating Bmp1 gene metalloproteinase isoforms: BMP1-3 (mTld) in healthy men and in patients with chronic kidney disease (CKD), BMP1-4 in liver cirrhosis (LC), BMP1-5 in acute myocardial infarction (AMI), and BMP1-7 in pancreatitis. We then showed that injections of BMP1-3 protein deteriorate, while BMP1-3 neutralizing polyclonal antibody improves the kidney function and prevents death in rats with CKD. In addition, inhibition of BMP1-3 alone and in combination with a BMP1-4 antibody improved the organ function in LC and AMI. We assume that BMP1-3 represents a core regulatory pathway molecule essential in fibrosis, and its targeting may be sufficient to limit fibrosis progression. In line with these findings, in this project we propose a new scientific concept in combating fibrosis using core and organ specific regulatory pathways, through pursuing the following objectives: 1/ to produce recombinant BMP1 isoform proteins and related neutralizing isoform-specific monoclonal antibodies; 2/ to determine specific BMP1 isoform substrates; 3/ to develop new sensitive plasma bioassays for measuring BMP1 isoforms in different animal experimental models;  4/ to explore the role of BMP1 isoforms in the pathology and function of animals with CKD and LC. The most efficacious monoclonal antibodies variable domain will be sequenced, and than humanized for potential development of new diagnostic tools and therapeutic application. This novel approach aims to acquire the first candidate specific treatment for halting or reversing the progression of CKD and LC. We hypothesize that modulation and/or inhibition of BMP1 isoforms represents future of diagnostic and therapeutic interventions in the field of molecular and translational medicine of fibrosis.]]></summary_en></project><project>
<id>2915</id><title_hr><![CDATA[Hiperfosforilacija, agregacija i transsinaptički prijenos tau proteina u Alzheimerovoj bolesti: analiza likvora i ispitivanje potencijalnih neuroprotektivnih spojeva]]></title_hr><title_en><![CDATA[Tau protein hyperphosphorylation, aggregation and trans-synaptic transfer in Alzheimer&#39;s disease: cerebrospinal fluid analysis and assessment of potential neuroprotective compounds]]></title_en><user_id>11124</user_id><user_firstLast_name>Goran Šimić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2014-09</proposal_call><code>IP-2014-09-9730</code><acronim><![CDATA[ALZTAUPROTECT]]></acronim><duration>12.10.2015 - 11.10.2019</duration><status>Završio</status><financ_value>132.722,81 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, Kliničke medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, Clinical sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb School of Medicine]]></institution_en><team_members_id>8532, 5057, 12685, 3314, 2684, 13238, 3319, 6740, 20884, 25387, 26549, </team_members_id><team_members_names><![CDATA[Mirjana Babić, Maja Jazvinšćak Jembrek, Danira Bažadona, Domagoj Đikić, Fran Borovečki, Vesna Benković, Nada Oršolić, Željka Petelin Gadže, Mirta Boban, Klara Zubčić, Ena Španić, ]]></team_members_names><keywords_hr><![CDATA[Alzheimerova bolest, cerebrospinalna tekućina (likvor), ELISA, neurofibrilarna degeneracija, neuroprotektivni spojevi, tau protein, tioflavin S ]]></keywords_hr><keywords_en><![CDATA[Alzheimer&#39;s disease, cerebrospinal fluid, ELISA, neurofibrillary degeneration, neuroprotective compounds, tau protein, thioflavine S]]></keywords_en><summary_hr><![CDATA[Za Alzheimerovu bolest (AB) ne postoji uzročno liječenje jer su brojni dosadašnji pokušaji intervencije temeljeni na amiloidnoj kaskadnoj hipotezi bili neuspješni. Usporedno s napretkom razumijevanja uloge tau proteina u patogenezi AB, metabolizam tau proteina je postao i važan terapijski cilj. Naime, smatra se da je u AB ravnoteža između kinaza i fosfataza tau proteina narušena, što dovodi do njegove hiperfosforilacije. Posljedično se povećava i frakcija tau proteina nevezanih za mikrotubule, pa se hiperfosforilirani tau monomeri vežu jedan za drugoga proizvodeći oligomere. Spajanje tau oligomera dovodi do oblikovanja sparenih uzvojitih filamenata, od kojih se sastoje sve neurofibrilarne promjene za koje je dokumentirano da predstavljaju najraniji neuropatološki događaj (tzv. &#39;&#39;pre-tangle&#39;&#39; stadij) od ključnog značaja za patogenezu AB. Ciljevi našeg projekta su: 1) bolje definirati odnos između bioloških biljega ranih stadija AB: ukupnih i fosforiliranih tau proteina, kao i amiloida ß u cerebrospinalnoj tekućini (likvoru) bolesnika s AD, MCI (blagi spoznajni poremećaj) i kontrolnih ispitanika. Uporabom inovativnog ELISA postupka i modificiranog eseja pomoću tioflavina S, u uzorcima likvora odrediti ćemo omjer između monomera i oligomera (agregata) tau proteina. Ti će novi podatci biti uspoređeni s kliničkim, neuropsihološkim i MRI nalazima; 2) testirati ćemo neke poznate i potencijalno neuroprotektivne spojeve (donepezil, klorgilin, nekoliko različitih flavonoida, te PF9601N i ASS234) na fosforilaciju tau proteina izazvanu okadaičnom kiselinom i nokodazolom u kulturama SH-SY5Y i P19 stanica. Epitope tau proteina fosforilirane na Thr181, Ser199 i Thr231 analizirati ćemo ELISA postupkom, a one na epitopima Thr202, Thr205, Ser396 i Ser404 pomoću westernske razložbe; i 3) istražiti ćemo biokemijski i imunocitokemijski transsinaptičko širenje neurofibrilarne degeneracije i razinu izraženosti tau mRNA nakon injekcije tau oligomera u entorinalnu moždanu koru miša.]]></summary_hr><summary_en><![CDATA[There is no effective treatment for Alzheimer’s disease (AD). As many drugs discovery attempts based on the amyloid cascade hypothesis have not been successful, tau protein has become an increasingly important therapeutic target owing to advances in understanding of its role in AD pathogenesis. In AD, the balance of tau kinase and phosphatase activity is shifted, creating a highly phosphorylated species of tau. This raises the fraction of unbound tau, which is no longer attached to microtubules, allowing for monomeric hyperphosphorylated tau to bind to one another to produce oligomers. Fusion of these oligomeric species leads to the formation of paired helical filaments, the primary constituent of neurofibrillary changes, which have been documented to be an early and pivotal event (so-called „pre-tangle“ stage) in the pathogenesis of AD. Our aims are: 1) to define better the relationship between the early AD biomarkers total and phospho-tau proteins, as well as amyloid ß in cerebrospinal fluid (CSF) of AD, MCI (mild cognitive impairment), and control subjects. By using innovative ELISA and modified thioflavin S binding assay on CSF samples, we will also assess the ratio between monomer and oligomer (aggregated) tau species. These new data will be correlated to clinical, neuropsychological, and MRI findings; 2) to test the effect of several known and potentially neuroprotective compounds (donepezil, clorgyline, several flavonoids, PF9601N and ASS234, among others) on tau phosphorylation induced by okadaic acid and nocodazole in SH-SY5Y and P19 cell cultures. Tau epitopes phosphorylated at Thr181, Ser199 and Thr231 residues will be analyzed by ELISA, while p-tau epitopes at Thr202, Thr205, Ser396 and Ser404 will be analyzed by Western blot; and 3) to investigate biochemically and immunocytochemically the trans-synaptic spreading of neurofibrillary degeneration and tau mRNA expression after the injection of tau oligomers in the mouse entorhinal cortex.]]></summary_en></project><project>
<id>2916</id><title_hr><![CDATA[Satelitska DNA u genskoj regulaciji i ekološkoj adaptaciji]]></title_hr><title_en><![CDATA[Satellite DNA in gene regulation and environmental adaptation ]]></title_en><user_id>183</user_id><user_firstLast_name>Đurđica Ugarković</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2014-09</proposal_call><code>IP-2014-09-3733</code><acronim><![CDATA[SatGenReg]]></acronim><duration>01.09.2015 - 30.11.2019</duration><status>Završio</status><financ_value>123.299,49 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Biologija, </scie_field_hr><scie_field_en>Biology, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>3003, 559, 1280, 21311, 21338, </team_members_id><team_members_names><![CDATA[Branka Bruvo Mađarić, Isidoro Feliciello, Zeljka Pezer Sakac, Antonio Sermek, JURE SKEJIĆ, ]]></team_members_names><keywords_hr><![CDATA[satelitska DNA, genska ekspresija, epigenetika, genska regulacija, adaptacija, Tribolium]]></keywords_hr><keywords_en><![CDATA[satellite DNA, gene expression, epigenetics, gene regulation, adaptation, Tribolium]]></keywords_en><summary_hr><![CDATA[Ponovljena DNA kao npr. transpozoni, može biti izvor regulatornih sekvenci te doprinijeti raspršenju regulatornih elemenata unutar eukariotskog genoma. Međutim, utjecaj na gensku regulaciju druge skupine vrlo zastupljenih, uzastopno ponovljenih sekvenci DNA kao što je satelitska DNA, nije do sada pokazan. U crvenom brašnaru Tribolium castaneum (Coleoptera) satelitska DNA igra važnu ulogu u regulaciji i remodeliranju heterokromatina tijekom razvoja i odgovora na vanjski stres. Ekspresija glavne satelitske DNA je jako potaknuta termičkim stresom, a povećana razina malih interferirajućih RNA (siRNA) koje potječu od satelitske DNA je praćena povećanjem represivnih epigenetskih modifikacija na histonima u heterokromatinu. Uz prisustvo u heterokromatinu, kratki odsječci satelitske DNA su raspršeni u blizini protein-kodirajućih gena u eukromatinu. Transkripcija glavne satelitske DNA osjetljiva na okolišne uvjete kao i njena raspršenost u susjedstvu gena upućuje na moguću ulogu satelitskih elemenata u regulaciji genske aktivnosti i adaptaciji na uvjete u okolišu.Cilj predloženog projekta je ispitati ulogu satelitske DNA u regulaciji aktivnosti gena u kukcu T. castaneum. Mi pretpostavljamo da siRNA koja potječe od satelitskih DNA utječe na epigenetski status dijelova eukromatina koji sadrže raspršene satelitske elemente na način da specifično navodi kromatinske modifikatore, primarno histonske metiltransferaze, na te regije. To može dovesti do nastanka heterokromatina na raspršenim satelitskim DNA elementima  i njegovog širenja na susjedna područja. Takova „heterokromatizacija“ može utjecati na ekspresiju susjednih gena, vjerojatno smanjujući njihovu aktivnost. Očekujemo da će naši rezultati po prvi put pokazati ulogu satelitskih DNA u podešavanju genske ekspresije i u ekološkoj adaptaciji.]]></summary_hr><summary_en><![CDATA[Repetitive elements such as transposons can be a source of regulatory sequences and could act to distribute regulatory elements throughout the genome. However, for the repetitive elements organized in tandem, known as satellite DNAs, role in gene regulation is not described till now. In the red flour beetle Tribolium castaneum (Coleoptera) satellite DNAs play an important role in heterochromatin regulation and remodelling during development and environmental stress response. Expression of a major satellite DNA is strongly induced by heat shock, and increased level of satellite-derived small interfering RNAs (siRNAs) is accompanied by increase of repressive epigenetic modifications of histones at heterochromatin. In addition to their presence in the heterochromatin, short stretches of satellite DNA have been mapped in the close vicinity of numerous genes within euchromatin. The environmentally susceptible transcription of a major satellite DNA as well as its distribution close to protein-coding genes provides strong support for the role of satellite DNA in gene regulation and adaptation to different environmental conditions.The aim of the proposed project is to investigate the gene-regulatory role of satellite DNAs in insect T. castaneum. We propose that satellite DNA-associated siRNAs could affect epigenetic state of euchromatic regions containing dispersed satellite elements by targeting these elements in a sequence-specific manner and by guiding chromatin modifiers, primarily histone methyltransferase. This could result in heterochromatin assembly at dispersed satellite DNA elements and its spreading to the flanking region. Such “heterochromatization” is expected to influence the expression of nearby genes, most probably by decreasing the level of gene expression. We expect that our results will for the first time demonstrate a role of satellite DNAs in the modulation of protein-gene expression and in environmental adaptation. ]]></summary_en></project><project>
<id>2920</id><title_hr><![CDATA[Model rasta aneurizme temeljen na biokemijskim i mehaničkim podražajima ]]></title_hr><title_en><![CDATA[BioChemoMechanical Modeling of Aneurysmal Growth]]></title_en><user_id>1010</user_id><user_firstLast_name>Igor Karšaj</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2014-09</proposal_call><code>IP-2014-09-7382</code><acronim><![CDATA[BCMModAneuGr]]></acronim><duration>01.10.2015 - 30.09.2019</duration><status>Završio</status><financ_value>115.747,56 eur</financ_value><scie_area_hr>Tehničke znanosti, Biomedicina i zdravstvo, </scie_area_hr><scie_area_en>Technological sciences, Biomedicine and health sciences, </scie_area_en><scie_field_hr>Strojarstvo, </scie_field_hr><scie_field_en>Mechnical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet strojarstva i brodogradnje]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Mechanical Engineering and Naval Architecture]]></institution_en><team_members_id>12954, 12791, 1012, 19003, 25392, </team_members_id><team_members_names><![CDATA[Ivo Lovričević, Vedran  Vindiš , Lana Virag, Nino Horvat, Josip Živić, ]]></team_members_names><keywords_hr><![CDATA[aneurizma, abdominalna aorta, intraluminalni tromb, rast i promjena strukture, hiperelastičnost, naprezanja, prilagodba, razgradnja elastina, kolagen]]></keywords_hr><keywords_en><![CDATA[aneurysm, abdominal aorta, intraluminal thrombus, growth and remodeling, hyperelasticity, stress, adaptation, elastin degradation, collagen turnover]]></keywords_en><summary_hr><![CDATA[Modeliranje biokemijskih kao i mehaničkih promjena tijekom razvoja intraluminalnog tromba (ILT) ima potencijal da pomogne nam odgovoriti na pitanje kako dolazi do rasta aneurizme i što uzrokuje njenu rupturu. Konačni cilj ovog istraživanja je utvrditi promjene koje s javljaju rastom aneurizme. Simulirat ćemo od početnog krvnog ugruška pa kasnog stadija aneurizme promjera većeg od 5 cm. Pretpostavljamo da povećanje AAA je izravna posljedica razvoja ILT.  Predlažemo sljedeće ciljeve za ovaj projekt:Cilj 1: Razviti model rasta i promjene strukture fuziformne aneurizme koji je moguće koristiti u paketu za konačne elemente.Cilj 2: Potrebno je razviti trodimenzijski model rasta i promjene strukture sakularne aneurizme s uključenim intraluminalnim trombom.Cilj 3: Potrebno je ispitati različite hipoteze o tome kako dolazi do rupture ili stabilizacije AAA na realističnoj geometriji.Uspješno ostvarenje navedenih ciljeva bit će veliki napredak u polju biomehanike krvnih žila jer će omogućiti po prvi put praćenje kinetike razvoja intraluminalnog tromba unutar AAA i otkrivanje faktora koji utječu na rast i rupturu aneurizme.]]></summary_hr><summary_en><![CDATA[Proper biochemomechanical modeling of the development of an intraluminal thrombus (ILT) has the potential to help us answer the question about reasons for aneurysmal growth and to define parameters influencing potential for rupture?. The overall goal of this project, therefore, is to quantify the development of ILT from the initial blood clot to a mature formation, with special attention to changes in the clot structure. Our hypothesis is that AAA growth is a direct consequence of ILT development. We propose following aims for this proposal:Aim 1: To develop a finite element growth and remodeling model of thrombus-laden fusiform aneurysm from the moment of initiation.Aim 2: To develop a 3-D finite element growth and remodeling model of thrombus-laden saccular abdominal aortic aneurysm from the healthy aorta.Aim 3: To test different hypothesis on AAA rupture and stabilization on realistic geometry from Aim 2.Successful realization of these aims will advance the field of vascular mechanics by allowing for the first time quantification of kinetics of an intraluminal clot within AAA, and factors that significantly influence aneurysmal growth and risk of the rupture. ]]></summary_en></project><project>
<id>2921</id><title_hr><![CDATA[Raspad Habsburške Monarhije i transfomacije na istočnojadranskom prostoru (1917.-1923.)]]></title_hr><title_en><![CDATA[THE COLLAPSE OF HABSBURG MONARCHY AND TRANFORMATIONS OF EASTERN ADRIATIC REGION (1917-1923)]]></title_en><user_id>1131</user_id><user_firstLast_name>Ante  Bralić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2014-09</proposal_call><code>IP-2014-09-7822</code><acronim><![CDATA[JADRANTRANSFORMACIJE]]></acronim><duration>15.05.2015 - 14.05.2019</duration><status>Završio</status><financ_value>52.491,21 eur</financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Povijest, </scie_field_hr><scie_field_en>History, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zadru]]></institution_hr><institution_en><![CDATA[University of Zadar]]></institution_en><team_members_id>3175, 1375, 2931, 4263, 2796, 2557, 2763, 2746, 22836, 914, </team_members_id><team_members_names><![CDATA[Zlatko Begonja, Zdravka Jelaska Marijan, Andreas Guidi, Branko Kasalo, Sanda Uglešić, Ante Gverić, Marko Trogrlić, Ante Batović, Matic  Batič, BORUT KLABJAN, ]]></team_members_names><keywords_hr><![CDATA[Istočni Jadran, Dalmacija, Habsburška Monarhija, Prvi svjetski rat, Elite]]></keywords_hr><keywords_en><![CDATA[Eastern Adriatic, Dalmatia, Habsburg Monarchy, World War One, Elites]]></keywords_en><summary_hr><![CDATA[Razdoblje između sloma Austro-Ugarske Monarhije i stvaranja novih država bilo je iznimno turbulentno razdoblje u političkom, društvenom i nacionalnom pogledu. Istraživanje bi započelo Svibanjskom deklaracijom 1917. godine koja je potaknula političko gibanje na, do tada “zamrznutoj” političkoj sceni, a završilo bi se završetkom povlačenja talijanskih vojnih snaga 1923. godine iz III. okupacijske zone. Poseban fokus bit će posvećen prilikama u Dalmaciji, a komplementarno će se analizirati prilike u drugim krajevima Istočnog Jadrana.Ciljevi projekta:1.	Objasniti utjecaj složenog sklopa uzroka koji su doveli do sloma Habsburške Monarhije i njihov utjecaj na javno mnijenje na istočnoj obali Jadrana, a posebno u Dalmaciji (1917.-1918.).2.	Istražiti utjecaj vanjskih, međunarodnih čimbenika na političke i društvene procese koji se odvijaju u promatranom razdoblju na istočnoj obali Jadrana u kontekstu nedefiniranih državnih granica i konfliktnih situacija. 3.	Proučiti promjene narativa u završnim procesima nacionalnih integracija (dalmatinskih Hrvata, Srba i Talijana, te tršćanskih Slovenaca) što je povezano s novim političkim i društvenim okruženjem.4.	Istražiti transformaciju i prilagođavanje &#39;starih&#39; elita novom društvenom okruženju.5.	Objasniti nastanak i djelovanje novih političkih organizacija nakon 1918. godine, te njihov utjecaj u dalmatinskom društvu.  Ova problematika je do sada, relativno slabo istražena. Jedan od najvećih problema je istovremeno i paraleno djelovanje više institucija na dalmatinskom i stičnojadranskom području u razdoblju od 1918. do 1923. što je osobito izraženo u prvom razdoblju do Rapallskog ugovora 1920.]]></summary_hr><summary_en><![CDATA[The period between the collapse of the Habsburg Monarchy and creation of new nation states was an exceptionally turbulent period in political, social and national sense. The research would begin with the May Declaration of 1917, which prompted political movement on previously “idle” political scene, and would end with final retreat of Italian military forces from the third occupation zone in 1923 in Dalmatia. Special focus will be devoted to the situation in Dalmatia, and complementary analysis will handle with the situation in other parts of the Eastern Adriatic.Project objectives:1.	Analyze complex set of causes that led to the collapse of the Habsburg Monarchy and their influence on public opinion in Eastern Adriatic region, especially in Dalmatia (1917-1918)2.	Explore the influence of external, international, factors on political and social processes in Dalmatia during the observed period, within the context of unidentified national borders and conflict situations.3.	Study the narrative changes in final processes of national integrations (of Dalmatian Croats, Serbs, and Italians, and Slovenes from Trieste) in connection to new political and social environment.4.	Investigate how the “old” elites transformed and adapted to new social environment.5.	Explain formation and activities of new political organizations after 1918 and their influence on Dalmatian society.This topic has not yet been fully explored. One of the biggest research issues are simultaneous and parallel activities of various different institutions in Dalmatia and other Eastern Adriatic regions between 1918 and 1923, particularly during the first period, prior to the Treaty of Rapallo.]]></summary_en></project><project>
<id>2923</id><title_hr><![CDATA[Mehanokemijska reaktivnost pod kontroliranim uvjetima temperature i atmosfere za čistu sintezu funkcionalnih materijala]]></title_hr><title_en><![CDATA[Mechanochemical reactivity under controlled temperature and atmosphere for clean synthesis of functional materials]]></title_en><user_id>280</user_id><user_firstLast_name>Krunoslav Užarević</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2014-09</proposal_call><code>UIP-2014-09-4744</code><acronim><![CDATA[MECHANOCONTROL]]></acronim><duration>01.04.2016 - 31.03.2019</duration><status>Završio</status><financ_value>130.201,08 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, </scie_field_hr><scie_field_en>Chemistry, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>196, 13070, 3012, 1007, 112, 625, 13224, 21253, 23293, 24360, </team_members_id><team_members_names><![CDATA[Martina Tireli, Emmerling Franziska, Davor Gracin, Marina Juribašić Kulcsar, Manda Ćurić, Ivan Halasz, Tomislav Friscic, Stipe Lukin, Bahar Karadeniz, Tomislav Stolar, ]]></team_members_names><keywords_hr><![CDATA[mehanokemijska sinteza, reaktivnost u čvrstom stanju, in situ monitoring, templatiranje i adsorpcija plinova, funkcionalizacija metal-ugljik veze]]></keywords_hr><keywords_en><![CDATA[mechanochemical synthesis, solid-state reactivity , in situ monitoring, gas-templation and adsorption, functionalization of metal-carbon bond]]></keywords_en><summary_hr><![CDATA[Mehanokemijske reakcije su se nametnule u posljednje vrijeme kao brza i ekološki prihvatljiva alternativa konvencionalnoj kemijskoj sintezi u velikom broju područja, od sinteze nanomaterijala i slitina do supramolekulskih organskih materijala i koordinacijskih mreža. Područje se posebno razvilo uvođenjem novih tehnika, tekućinom potpomognutog mljevenja ili ionima- i tekućinom potpomognutog mljevenja, koji uključuju dodatak aditiva u reakcijske smjese. Unatoč velikom broju objavljenih radova, načini kontrole osnovnih reakcijskih uvjeta, poput temperature i tlaka unutar mehanokemijskog reaktora, još uvijek nisu uvedeni u standardne mehanokemijske postupke. Štoviše, znanja o utjecaju reakcijskih uvjeta i aditiva na mehanizme reakcija mljevenja su još na spekulativnom nivou.Glavni cilj predloženog projekta je istraživanje fundamentalnih aspekata mehanokemijskih reakcija pod kontroliranom tlakom i u određenom rasponu temperatura. Okolišno relevantni plinovi (poput ugljikova(IV) oksida, metana, sumporovih i dušikovih oksida) će se koristiti kao templati ili reaktanti za sintezu poroznih koordinacijskih spojeva ili organskih spojeva. Također, ispitati će se vezanje plinova na neporozne koordinacijske spojeve, te funkcionalizacija ugljikovih atoma iz organometalnih spojeva.Da bismo uspješno ostvarili ciljeve projekta, razviti ćemo mehanokemijske reaktore u kojima će biti moguće kontrolirati temperaturu i tlak. Mehanistički aspekti mehanokemijskih reakcija između plinova i krutina biti će određeni in situ tehnikama praćenja nedavno razvijenih unutar naše grupe.Iskustvo i saznanja prikupljeni implementacijom ovoga projekta će se iskoristiti za istraživanja mehanokemijske sinteze ciljanih materijala, a s krajnjim ciljem stjecanja dubljeg uvida u mehanokemijske reakcije i proširenja  potencijala za njihovu primjenu. Očekujemo da će rezultati projekta imati snažan utjecaj na korištenje reakcija u čvrstom stanju, kako u istraživačkim laboratorijima, tako i u kemijskoj industriji.]]></summary_hr><summary_en><![CDATA[Mechanochemical reactions by milling have recently emerged as excellent, rapid and cleaner alternative to conventional solution synthesis in a number of areas, from nanomaterials and alloys to supramolecular, organic materials and metal-organic frameworks. The area flourished after the introduction of new techniques, liquid-assisted grinding and ion- and liquid assisted grinding, involving additives in the reaction mixtures. Despite a growing rate of published articles, the means of controlling the basic milling reaction conditions, such as temperature and pressure in the vessel, is still not a part of standard milling procedures. Moreover, understanding of the effect of reaction conditions and additives on milling-reaction mechanisms is currently on speculative level.The main objective of this project proposal is to explore fundamental aspects of mechanochemical solid-state reactions under controlled pressure and in a range of temperatures. We will employ different gases (with special focus on environmentally relevant gases such as carbon dioxide, methane and sulfur- or nitric oxides) as reacting agents and templates for the synthesis of porous metal-organic and covalent organic frameworks, to selectively bind pollutant gases to nonporous coordination compounds or to functionalize carbon atoms in organometallic compounds. To successfully implement the objectives of this project proposal, we will develop milling vessels where the described reaction conditions can be achieved. Mechanistic aspects of gas-solid milling reactions will be studied by our novel in situ and real-time monitoring techniques.The experience and knowledge acquired by the project implementation will be applied to mechanochemical formation of target materials in order to broaden understanding and application scope of mechanochemical reactivity. The project results are expected to have a strong transformative effect on solid-state reactivity in a research laboratory as well as in chemical industry.]]></summary_en></project><project>
<id>2933</id><title_hr><![CDATA[Modulacija metaboličkog, endokrinog i antioksidacijskog statusa u mliječnih krava dodavanjem zeolita u hranu]]></title_hr><title_en><![CDATA[Modulation of metabolic, endocrine and antioxidative status in dairy cows by dietary zeolite supplementation]]></title_en><user_id>11178</user_id><user_firstLast_name>Marko Samardžija</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2014-09</proposal_call><code>IP-2014-09-6601</code><acronim><![CDATA[ModZeCow]]></acronim><duration>15.09.2015 - 14.09.2019</duration><status>Prekinut</status><financ_value>132.722,81 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Veterinarska medicina, </scie_field_hr><scie_field_en>Veterinary medicine, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Veterinarski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Veterinary Medicine]]></institution_en><team_members_id>2794, 11250, 11252, 11248, 12376, 11275, 11271, 11273, 11257, 5216, 11266, 12374, 11247, 11245, 3086, 11258, </team_members_id><team_members_names><![CDATA[Miroslav Benić, Tomislav Dobranić, Vesna Dobranić, Dražen Đuričić, Zlata Flegar-Meštrić, Ivan Folnožić, Iva Getz, Damjan Gračner, Juraj Grizelj, Martina Lojkić, Nino Maćešić, Sonja Perkov, Paola Roncada, Romana Turk, Hrvoje Valpotić, Silvijo Vince, ]]></team_members_names><keywords_hr><![CDATA[NEB, zeolit u hrani, plodnost, mastitis, mliječne krave]]></keywords_hr><keywords_en><![CDATA[NEB, dietary zeolite, fertility, mastitis, dairy cows]]></keywords_en><summary_hr><![CDATA[Nakon porođaja, naglo se povećaju hranidbene potrebe organizma zbog proizvodnje mlijeka i krave ulaze u razdoblje negativnog energetskog statusa (NEB) koji neposredno utječe na funkciju jajnika prouzrokujući izostanak pravilne ciklične aktivnosti jajnika tijekom puerperija i smanjenje plodnosti. NEB nije moguće izbjeći, ali je zato moguće umanjiti njegovo trajanje i jačinu. Reproduktivni poremećaji u krava mogu se pripisati značajnom smanjenju tjelesne kondicije tijekom puerperija kao i sistemskim promjenama metaboličkih, endokrinih i oksidacijskih pokazatelja zbog nedostatnog unosa hrane. Posljedično, energetska neravnoteža zbiva se zbog povećane mliječnosti nakon porođaja, periporođajnog stresa i/ili bolesti koje se javljaju tijekom puerperija. Te bolesti imaju značajan negativni ekonomski utjecaj tijekom puerperija i u razdoblju nakon njega zbog pojave trajne jalovosti. Jedna od najznačajnijih bolesti krava tijekom puerperija je mastitis koji prouzrokuje znatne ekonomske gubitke, zbog otežane dijagnostike subkliničkog oblika. Smatra se da zeolit klinoptilolit (KPL) može modulirati metabolički, endokrini i antioksidacijski status u mliječnih krava i stoga unaprijediti njihovo zdravlje, plodnost i mliječnost. Ciljevi projekta su vrednovati učinke nutritivne modulacije KPL u hrani na NEB, plodnost i produktivnost te pojavnost subkliničkog mastitisa radi rane dijagnostike oksidacijskog stresa i sistemskog/lokalnog upalnog odgovora povezanog s reproduktivnim i produktivnim poremećajima u mliječnih krava. Očekivani rezultati istraživanja na projektu uključit će dobro definirane pozitivne učinke nutritivne modulacije dodatkom KPL u hranu na: (1) NEB, plodnost i produktivnost s obzirom na tjelesnu kondiciju i paritet tijekom prijelaznog razdoblja i kasnog puerperija; (2) pojavnost/jačinu subkliničkog mastitisa u mliječnih krava. Sveukupno, ti će učinci u praksi doprinijeti unaprjeđenju zdravlja i ekonomskih pokazatelja u govedarskoj proizvodnji u Hrvatskoj i inozemstvu. ]]></summary_hr><summary_en><![CDATA[Nutritional requirements of dairy cows are rapidly increasing following parturition due to milk production and thus animals inevitably enter into negative energy balance (NEB) which indirectly affecting ovaries function causing failure of regular ovarian activity during puerperium and consequently decreased fertility. The NEB could not be avoided by any known treatments but it is possible to decrease its duration and severity. Reproductive disorders in cows could be ascribed to significant decrease of body condition during puerperium and to systemic changes of metabolic, endocrine and oxidative parameters due to insufficient feed intake. Consequently, energy imbalance occurs due to increased milk production following parturition, peripartal stress and/or puerperal diseases. Such diseases have significant negative economic impact, during puerperium and afterwards by appearance of sterility. One of the most important puerperal diseases is mastitis which causes large economic losses particularly due to difficulties in diagnosis of its subclinical form. It is assumed that zeolite clinoptilolite (CPL) might modulate metabolic, endocrine and antioxidative status in dairy cows and thus improve their health, fertility and milk production. The objectives of the project are to evaluate effects of nutritive modulation by dietary CPL on: NEB, fertility, productivity and incidence of subclinical mastitis for early recognition of oxidative stress and systemic/local inflammatory responses involved in reproductive and productive disorders in dairy cows. The expected outcomes of the project will include well defined positive effects of nutritive modulation by dietary CPL on: (1) NEB, fertility and productivity regarding body condition and parity during transition period and late puerperium; (2) incidence/severity of subclinical mastitis in dairy cows. Altogether, these will contribute in practice to improve health and economical parameters in cattle production in Croatia and abroad.]]></summary_en></project><project>
<id>2934</id><title_hr><![CDATA[JADRANSKA PRIČA - INTERDISCIPLINARNO ISTRAŽIVANJE JADRANSKIH NARATIVA]]></title_hr><title_en><![CDATA[ADRIATIC TALE - INTERDISCIPLINARY RESEARCH OF ADRIATIC NARRATIVES]]></title_en><user_id>8327</user_id><user_firstLast_name>Joško Božanić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2014-09</proposal_call><code>IP-2014-09-9300</code><acronim><![CDATA[ADRIANA]]></acronim><duration>01.10.2015 - 30.09.2019</duration><status>Završio</status><financ_value>76.293,05 eur</financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Filologija, Etnologija i antropologija, </scie_field_hr><scie_field_en>Philology, Ethnology and anthropology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Splitu, Filozofski fakultet]]></institution_hr><institution_en><![CDATA[University of Split, Faculty of Humanities and Social Sciences]]></institution_en><team_members_id>12702, 12699, 11114, 12688, 12608, 13033, 13303, 13535, 13610, 12992, 7827, 13358, 24402, </team_members_id><team_members_names><![CDATA[Anita Runjić-Stoilova, Inoslav Bešker, Eni Buljubašić, Marijana Tomelić Ćurlin, Marina Blagaić Bergman, Antonela Pivac, Filip Galović, Natalie Dupré, Elis Deghenghi Olujic, Ines Grgurinović, Danica Škara, Srecko Jurisic, Paula Jurišić, ]]></team_members_names><keywords_hr><![CDATA[humorizam, književnost, usmenost, stilistika, Jadran, dijalekt, narativ, semiotika]]></keywords_hr><keywords_en><![CDATA[humorism, literature, orality, stylistics, Adriatic, dialect, narrative, semiotics]]></keywords_en><summary_hr><![CDATA[ Atribut „jadranski“ ne pojavljuje se u hrvatskoj književnoj historiografiji ni znanosti o književnosti kao kvalifikativ koji bi definirao literarnu posebnost ni kao stilska, ni kao tematska, niti kao kulturološka odrednica. Zanemarivanje maritimnosti rezultira redukcijom kulturološkog diverziteta u recepciji nacionalne književnosti, umjetničke i usmene. Polazeći od teze da je kvalifikativ „jadranski“ bitna odrednica jednog od hrvatskih kulturnih identiteta, ovaj projekt želi doprinijeti istraživanju fenomena maritimnosti hrvatske kulture na području narativa oralne pripovjedne  književnosti, kako fikcionalne tako i nefikcionalne, i njena refleksa u narativima umjetničke književnosti u sinkronijskoj i dijakronijskoj perspektivi. U tome je i specifičan doprinos ovoga  projekta budući da on pokriva veliko neistraženo područje usmene književnosti i njena utjecaja na umjetničku književnost. Projekt se temelji na ideji sustavnog istraživanja usmene i zapisane građe oralne nefikcionalne i fikcionalne književnosti, izvan klasičnog folklorističkog okvira percepcije fenomena literarature kao žanrovski i poetološki definiranog diskursa. Ovo istraživanje nije strogo omeđeno granicama jezika jednog etnosa (hrvatskog), već uključuje i transetničke utjecaje i prožimanja zadana istom kulturalnom matricom adrianstva. To je dijaloška kultura čiji je temeljni princip humorizam. Zapisat će se i sistematizirati prikupljena građa te provesti sustavna analiza, valorizacija i interpretacija tekstova s različitih aspekata: literarnog, lingvističkog, etnološkog i kulturnoantropološkog, komparativnog i rodnog, a istraživanje će uključiti različite tipove interpretacije na područjima: stilistike, naratologije, književne teorije, dijalektologije, leksikologije / leksikografije, semiotike, retorike, etnografije i kulturne antropologije. Pragmatični dio istraživačkog programa realizirat će se dizajniranjem atraktivnih ambijentalnih narativa za potrebe jadranskih kulturnih itinerara.]]></summary_hr><summary_en><![CDATA[Within Croatian literary theory and historiography, the attribute ‘Adriatic’ does not signify any (relevant) determinant of literary quality, whether stylistic, thematic or cultural. The disregard of the maritime cultural aspects reduces the cultural diversity in the reception of national literature, both authored/written and oral. With the premise that the attribute &#39;Adriatic&#39; is a significant determinant of one of Croatia&#39;s cultural identities, this project aims to contribute to the research of the phenomenon of Croatian culture&#39;s maritimity in the area of oral literature narratives,  both fictional and non-fictional, as well as narratives of national written literature in its synchronic and diachronic perspective. The outstanding value and specific contribution of this project is in covering a field that has not yet been researched in Croatian literary studies. The project is based on the idea of definition, interpretation and valorisation of the Adriatic component of Croatian literature and the systematic research of oral and recorded stories of various narrative and protonarrative types related to specific areas of the Adriatic space. The collected data will be systematized and subjected to a detailed analysis and textual interpretation from various perspectives: literary, linguistic, ethnological, cultural, antropological, comparative and the perspective of gender. The research will include various types of interpretation in the areas of stylistics, narratology, literary theory, dialectology, lexicology / lexicography, semiotics, rhetoric, ethnography and cultural anthropology. Results will be dissaminated through the publication of books and research papers in internationally cited journals and proceedings of the international conference on the subject of this project. The practical side of this research project will be implemented through the creation of attractive ambient narratives as the basis of Adriatic cultural itineraries. ]]></summary_en></project><project>
<id>2936</id><title_hr><![CDATA[RIMSKI GROBNI SPOMENICI JUGOZAPADNE PANONIJE U SVOME MATERIJALNOM, DRUŠTVENOM I RELIGIJSKOM KONTEKSTU]]></title_hr><title_en><![CDATA[ROMAN FUNERARY MONUMENTS OF SOUTH-WESTERN PANNONIA IN THEIR MATERIAL, SOCIAL, AND RELIGIOUS CONTEXT]]></title_en><user_id>7449</user_id><user_firstLast_name>branka migotti</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2014-09</proposal_call><code>IP-2014-09-4632</code><acronim><![CDATA[RGSP/RFMP]]></acronim><duration>04.05.2015 - 03.05.2018</duration><status>Završio</status><financ_value>45.924,35 eur</financ_value><scie_area_hr>Humanističke znanosti, Prirodne znanosti, </scie_area_hr><scie_area_en>Humanities, Natural sciences, </scie_area_en><scie_field_hr>Arheologija, Geologija, </scie_field_hr><scie_field_en>Archeology, Geology, </scie_field_en><institution_hr><![CDATA[Hrvatska akademija znanosti i umjetnosti]]></institution_hr><institution_en><![CDATA[Croatian Academy of Sciences and Arts]]></institution_en><team_members_id>3706, 4660, 3255, 4105, 6682, </team_members_id><team_members_names><![CDATA[Marjeta Šašel Kos, Ivan Radman-Livaja, Ljubica Perinić, Mirko Belak, Hana Ivezić, ]]></team_members_names><keywords_hr><![CDATA[interdisciplinarno istraživanje, jugozapadna Panonija, sjeverna Hrvatska, grobni spomenici, provincijalno-rimsko društvo]]></keywords_hr><keywords_en><![CDATA[interdisciplinary research, south-western Pannonia, northern Croatia, funerary monuments, Romano-provincial society]]></keywords_en><summary_hr><![CDATA[Interdisciplinarno (arheologija, epigrafija, geologija) i cjelovito evidentiraju se, proučavaju i sistematiziraju kameni grobni spomenici triju jugozapadno-panonskih rimskih gradova na prostoru sjeverne Hrvatske: Andautonije  (Ščitarjevo), Siscije (Sisak) i Akva Balisa (Daruvar). Aspekti proučavanja su povijesni, umjetnički i materijalni, a uključuju uvid u odabir vrste spomenika (tituli, stele, sarkofazi, urne, oltari i portretne niše) i odgovarajućeg grobnog rituala (spaljivanje ili tjelesno pokapanje), analize oblika i struktura spomenika, ikonografije i natpisa, te određivanju vrste kamena i kamenolomskog podrijetla. Sistematizacija navedenih podataka omogućit će bolji uvid u društveni i kulturni profil južno-panonskog provincijalnog društva: socijalnu stratifikaciju (statusnu i položajnu, te civilnu i vojničku),  etničke identitete, religijsku pripadnost, te umjetničke trendove i gospodarske aspekte (nastanak domaćih radionica i trgovina mramornim i kamenim izrađevinama na prostoru Norika i Panonije). Prikupljanjem, sistematizacijom i analizom građe koja nikad prije nije bila razmatrana na taj način, osmislit će se svojevrstan pilot projekt, primjenjiv na druge gradove i regije  Rimskog carstva.]]></summary_hr><summary_en><![CDATA[Funerary monuments of  three south-western Pannonian Roman cities in the territory of northern Croatia (Andautonia, Siscia, and Aquae Balissae) are evidenced, compiled, studied, and systematised through an interdisciplinary (archaeological, epigraphic, and geological) and holistic approach. Aspects of the research are historical, artistic, and material, comprising the choice of the monument type (tituli, stelae, sarcophagi, ash-chests, altars, and portrait niches) and corresponding funerary rite (incineration or inhumation), analyses of the monument forms and structures, iconographies, epigraphy, and stone characterisation, that is, establishing the stone used and its quarry source. A systemisation of the acquired data will enable a better insight into the social and cultural profile of the south-Pannonian provincial society, concerning its social stratification (military and civil ranks and statuses), ethnic identities, religious affiliations, artistic trends, as well as economic and trade aspects (the establishment of local stonemasonry workshops and trade in marble and other stone funerary monuments in the Norico-Pannonian region). Through compiling, systematising and analysing of the evidence that had so far never been studied in this way, a kind of a pilot project will be produced, applicable to other towns or regions of the Roman Empire. ]]></summary_en></project><project>
<id>2949</id><title_hr><![CDATA[Novi metodološki pristup biogeokemijskim istraživanjima specijacije metala u tragovima u obalnim vodenim ekosustavima]]></title_hr><title_en><![CDATA[New methodological approach to biogeochemical studies of trace metal speciation in coastal aquatic ecosystems]]></title_en><user_id>12557</user_id><user_firstLast_name>Dario Omanović</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2014-09</proposal_call><code>IP-2014-09-7530</code><acronim><![CDATA[MEBTRACE]]></acronim><duration>01.09.2015 - 31.12.2019</duration><status>Završio</status><financ_value>124.759,44 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, Geologija, </scie_field_hr><scie_field_en>Chemistry, Geology, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>827, 101, 4198, 120, 75, 80, 691, 1423, 106, 12837, 5519, 5147, 13204, 13205, 20234, 19764, 23224, 20391, </team_members_id><team_members_names><![CDATA[Ivanka Pižeta, Marina  Mlakar, Neven Cukrov, Vlado Cuculić, Marta Plavšić, Stanislav Frančišković-Bilinski, Petra Vukosav, Vesna Žic, Slađana Strmečki Kos, Ana-Marija Cindrić, Sunčana Geček, Niko Bačić, Garnier Cédric, Lenoble Veronique, Jasmin Pađan, Nuša Cukrov, Saša Marcinek, Filip Pošćić, ]]></team_members_names><keywords_hr><![CDATA[metali u tragovima, specijacija, obalni vodeni ekosustavi, modeliranje,  sedimenti, zagađivala]]></keywords_hr><keywords_en><![CDATA[trace metals, speciation, coastal aquatic ecosystems, modeling, sediments, contaminants]]></keywords_en><summary_hr><![CDATA[Predloženo istraživanje ima za cilj razjasniti nekoliko pitanja vezanih za fizičko-kemijske procese koji reguliraju ponašanje tragova metala (TM) u čistim, ali i u potencijalno zagađenim prijelaznim i priobalnim vodenim ekosustavima. Pokretljivost, reaktivnost kao i bioraspoloživost MT-ova jako ovise o njihovoj kemijskoj specijaciji, bez obzira imaju li ulogu mikronutrijenata ili  su izrazito toksični za organizme.Naša istraživanja usmjerena prema karakterizaciji međusobnog odnosa TM-ova s ostalim makro i mikro konstituentima prirodnih voda, posebno s prirodnom organskom tvari, bit će temeljena na korištenju najnovijih elektrokemijskih i složenih spektrometrijskih tehnika za specijaciju metala. Orijentirat ćemo se naročito na razvoj i usavršavanje metoda za specijaciju, mjernih protokola i mjernih senzora. Modele raspodjele metala razvijene u laboratorijskim uvjetima ispitat ćemo na uzorcima prirodne vode, a primijenit ćemo ih i kod on-site i in-situ mjerenja. Istraživanja će voditi do uspostavljanja niza specifičnih fizičko-kemijskih parametara, procedura i kriterija koja će omogućiti pouzdanu procjenu aktualnog stanja ali i predviđanje budućeg ponašanja TM-ova (specijaciju, mobilnost, biodostupnost/toksičnost) u slučaju lokalnih okolišnih nezgoda (npr. zagađenja) ili globalnih prijetnji (npr. “ocean acidification”).Istraživanja će se provoditi u vodnim područjima raznolikog kemijskog sastava gdje se očekuju promjene fizičko-kemijskih oblika TM-ova (As, Cd, Co, Cr, Cu, Fe, Hg, Ni, Pb, Zn), a uključivat će estuarijska, oksično/anoksična, eutrofička, te čista i zagađena područja, u kojima će se istraživati procesi koji se odvijaju kako na granicama faza, tako i u vodenom i sedimentnom stupcu.Teme istraživanja odabrane su tako da rezultati projekta budu od koristi ne samo široj znanstvenoj zajednici koja radi na problemima specijacije TM-ova nego i institucijama ovlaštenim za upravljanje priobalnim područjima.]]></summary_hr><summary_en><![CDATA[The proposed research aims at elucidating several issues related to the physico-chemical processes governing trace metals (TM) behaviour in pristine, but also in potentially contaminated transitional and coastal aquatic ecosystems. Whether the TMs behave as micronutrients or are highly toxic to organisms, their mobility, reactivity as well as bioavailability, strongly depends on chemical speciation.Our focus will be directed towards characterisation of interactions of TM with other macro and micro constituents of natural waters, particularly with natural organic matter, by employing the most recent approaches utilizing electrochemical and hyphenated spectrometric techniques. Particular effort will be invested in the development and improvement of speciation methods, measurement protocols and sensing electrodes. Methodologies developed under controlled laboratory conditions will be verified using natural water samples and applied in on-site and in-situ field-studies. The research will lead to the establishment of sets of specific measures and criteria which will allow reliable estimation of the actual state, but also the prediction of future behaviour of TMs (speciation, mobility, bioavailability/toxicity) in case of local environmental accidents (e.g. contamination) or global threats (e.g. ”ocean acidification”).Aquatic environments characterized by a variety of chemical compositions will be studied. In such conditions, variations in physical-chemical forms of the studied TMs (As, Cd, Co, Cr, Cu, Fe, Hg, Ni, Pb, Zn) are expected to occur. Study sites will be estuarine, oxic/anoxic, eutrophic and clean/contaminated areas, in which processes occurring at the phase boundaries, as well as in the sediment and water column will be explored.The specific subjects of the research are selected in a way to enable the outcome of the project be valuable not only to the broad scientific community working on TM speciation, but also to the authorities managing coastal zones.]]></summary_en></project><project>
<id>2952</id><title_hr><![CDATA[Menadžment sportskih doživljaja u funkciji oblikovanja učinkovitih poslovnih modela u slabije razvijenim turističkim destinacijama]]></title_hr><title_en><![CDATA[Management of sports experiences in the function of designing effective business models in less developed tourist destinations]]></title_en><user_id>2667</user_id><user_firstLast_name>Marko Perić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2014-09</proposal_call><code>UIP-2014-09-1214</code><acronim><![CDATA[SPORTBIZMODEL]]></acronim><duration>01.06.2015 - 31.05.2018</duration><status>Završio</status><financ_value>38.307,25 eur</financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Ekonomija, </scie_field_hr><scie_field_en>Economy, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Fakultet za menadžment u turizmu i ugostiteljstvu]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Tourism and Hospitality Managment]]></institution_en><team_members_id>4489, 3013, 2701, 3425, 2894, 6818, </team_members_id><team_members_names><![CDATA[Nicholas  Wise, Sanela Škorić, Daniel  Dragičević, Nataša Kovačić, Jelena Đurkin, Vanja Vitezić, ]]></team_members_names><keywords_hr><![CDATA[Poslovni model, menadžment, sportski doživljaji, sportski turizam, turistička destinacija]]></keywords_hr><keywords_en><![CDATA[Business model, management, sports experiences, sports tourism, tourist destination]]></keywords_en><summary_hr><![CDATA[Opći cilj ovog istraživanja je predložiti učinkovite poslovne modele koji će omogućiti pružateljima usluga sportskog turizma u manje razvijenim turističkim destinacijama da se prilagode tržišnim izazovima te, usredotočujući se na pružanje sportskih doživljaja, održe i povećaju svoje tržišne udjele i pozitivne ekonomske učinke. Formulirano je nekoliko hipoteza: (1) sportski doživljaji koje turisti traže značajno se razlikuju jedni od drugih i mogu biti razvrstani u nekoliko karakterističnih skupina, (2) glavni elementi postojećih poslovnih modela u sportskom turizmu u slabije razvijenim destinacijama identični su glavnim elementima postojećih poslovnih modela najbolje prakse, ali se njihova primjena u praksi razlikuje; (3) analizom prikupljenih primarnih kvalitativnih podataka o karakteristikama postojećih poslovnih modela u sportskom turizmu, moguće je doći do spoznaja relevantnih za oblikovanje učinkovitih poslovnih modela sposobnih pružiti različite vrste sportskih doživljaja. Gorski kotar, kao jedna on slabije razvijenih destinacija u Hrvatskoj, prikladna je lokacija za istraživanje ovih teza. Identificirat ćemo i procijeniti ponudu sportskih sadržaja te provesti anketiranje sportskih turista u Gorskom kotaru kako bi generirali nekoliko vrsta sportskih doživljaja i utvrdili potencijalni odnos između vrsta sportskih doživljaja i izdataka turista. Radi usporedbe identična procedura će se primijeniti i na nekoliko odabranih primjera sportskih događaja i aktivnosti (najbolje prakse) izvan područja Gorskog kotara. Konačno, provest ćemo i interakcijsko istraživanje postojećih poslovnih modela u Gorskom kotaru i najboljih praksi izvan njega. Na taj način dobit ćemo bolji uvid u poslovne modele koji pružaju pojedine doživljaje i moći ćemo predložiti novu verziju konceptualnih poslovnih modela za sve vrste sportskih doživljaja. Spoznaje do kojih ćemo doći mogu biti od velike koristi pružateljima usluga sportskog turizma u Gorskom kotaru i drugim sličnim destinacijama. ]]></summary_hr><summary_en><![CDATA[The overall objective of this research is to propose efficient business models which will allow sports tourism providers in less developed tourist destinations to adapt to the current market challenges and, being focused on providing sports experiences, to maintain and increase their market shares and positive economic impacts. Few hypotheses are formulated: (1) sports experiences that tourists seek differ significantly from one another and can be sorted in several characteristic groups; (2) the main elements of the existing business models of sports tourism in less developed tourist destinations are identical to the main elements of the existing business models of best practice, but their application in practice differ; (3) by analysing the collected primary qualitative data on the characteristics of the existing business models of sports tourism, it is possible to reach knowledge relevant to the design of effective business models capable to provide different types of sports experiences. Gorski kotar (GK) as one of the least developed tourist destinations in Croatia may be appropriate location to explore these issues. We will identify and assess the supply-side (sports events and activities) and conduct a survey on sports tourists in GK in order to generate several types of sports experiences and to determine potential relationship between the types of sports experiences and expenditure of tourists. For benchmarking purposes the same procedure will be applied on selected best practices outside the area of GK. Finally, we will conduct interaction research on existing business models in GK and external best practices. In this way we will get better insight into the business models that deliver different experiences and we will be able to propose the conceptual business models for all types of sports experience. New findings on business models could be of significant benefit for sports tourism providers in GK and other similar destinations.]]></summary_en></project><project>
<id>2953</id><title_hr><![CDATA[Akumulacija, unutarstanično mapiranje i učinci metala u tragovima u akvatičkih organizama]]></title_hr><title_en><![CDATA[Accumulation, Subcellular Mapping and Effects of Trace Metals in Aquatic Organisms]]></title_en><user_id>724</user_id><user_firstLast_name>Marijana Erk</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2014-09</proposal_call><code>IP-2014-09-4255</code><acronim><![CDATA[AQUAMAPMET]]></acronim><duration>01.09.2015 - 31.12.2019</duration><status>Završio</status><financ_value>127.739,07 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Biologija, Kemija, </scie_field_hr><scie_field_en>Biology, Chemistry, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>11261, 12330, 11251, 11253, 12349, 12871, 12351, 169, 12386, 12339, 12553, 21287, 24444, 25177, </team_members_id><team_members_names><![CDATA[Zrinka Dragun, Vlatka Filipović Marijić, Dušica Ivanković, NESRETE  KRASNIĆI, Renata Matoničkin Kepčija, Sanja Gottstein, Mirela Sertić Perić, Marko  Miliša, Jasna Lajtner, Dirk Schaumlöffel, Etienne GONTIER, Tatjana Mijošek, Zuzana Redžović, Maria de los Angeles Subirana Manzanares, ]]></team_members_names><keywords_hr><![CDATA[metali u tragovima, oslikavanje metala u stanici, unutarstanična raspodjela metala, biomarkeri, toksikologija okoliša, procjena utjecaja na okoliš]]></keywords_hr><keywords_en><![CDATA[trace metals, cellular metal imaging, subcellular metal distribution, biomarkers, environmental toxicology, environmental impact assessment]]></keywords_en><summary_hr><![CDATA[Cilj predloženog projekta je unaprjeđenje dosadašnjih i stjecanje novih spoznaja o tome kako se ribe, rakušci, školjkaši i nametnici riba (kukaši) nose s povišenim koncentracijama metala u slatkovodnim ekosustavima, što će se postići povezivanjem podataka o koncentracijama metala u vodi, akumuliranim metalima te o biomarkerima u bioti s podacima o unutarstaničnom mapiranju metala. Ovo pitanje će se istraživati na različitim biološkim razinama, od unutarstanične do razine organizma, što će omogućiti utvrđivanje načina suočavanja s metalima na različitim razinama biološke organizacije. Multielementna analitička tehnika primijenit će se za analizu metala/metaloida u vodi i u uzorcima biote. U odabranim akvatičkim organizmima istražiti će se i skup biomarkera, uključujući biomarkere općeg stresa te izloženosti i učinaka metala. Oslikavanje metala u stanici provest će se masenom spektrometrijom sekundarnih iona (NanoSIMS), koja trenutno predstavlja najnovije dostignuće tehnike, a omogućava određivanje, vizualiziranje i kvantificiranje raspodjele metala na unutarstaničnoj razini u biološkim materijalima. Primjena NanoSIMS-a u predloženom projektu omogućit će po prvi puta uvid u kretanje i raspodjelu metala u tkivima i stanicama akvatičkih organizama, koji žive u uvjetima povećane izloženosti metalima. Spoznaje, koje će biti rezultat projekta, omogućit će bolje razumijevanje procesa u stanicama i tkivima u kojima sudjeluju metali, kao i posljedica izloženosti akvatičkih organizama metalima. Dodatni cilj je procjena antropogenog utjecaja s obzirom na zagađenje metalima/metaloidima na odabrane slatkovodne ekosustave (rijeke Krka, Ilova), objedinjavanjem kemijskog, biokemijskog i biološkog pristupa, kao i procjena rizika po zdravlje ljudi. Nadalje, rezultati će doprinijeti razvoju planova upravljanja vodama te je stoga ovo istraživanje od strateškog značaja za Republiku Hrvatsku. Predloženi projekt će također omogućiti obrazovanje i usavršavanje nove generacije znanstvenika.]]></summary_hr><summary_en><![CDATA[The aim of the proposed project is to increase our understanding and gain new knowledge on how fish, crustaceans, bivalves and fish parasites (acantocephalans) cope with elevated metal concentrations in freshwater ecosystems by relating data on metal concentrations in water, accumulated metals and biomarker responses in biota to data on intracellular metal mapping. This issue will be tackled at different biological levels, from subcellular to organism, thus establishing how different levels of biological organisation cope with metal exposure. Multielemental analytical technique will be applied to analyse metals/metalloids in water and biota samples and the suit of biomarkers will be studied on selected aquatic organisms encompassing biomarkers of general stress and biomarkers of metal exposure and effect. Secondary ion mass spectrometry (NanoSIMS), as a new, state-of-the-art technique, will be applied for cellular metal imaging in order to measure, visualize and quantify the distribution of specific metals at the sub-cellular level in biological materials. The application of NanoSIMS in the proposed project will for the first time enable the insight into the circulation of metals within tissues and cells of aquatic organisms living under increased metal exposure. The resulting information of the proposed project will generally contribute to better understanding of metal processes in cells and tissues and consequences of metal exposure in aquatic organisms. Additional aim of the project is to evaluate anthropogenic impact on selected freshwater ecosystems (rivers Krka, Ilova) referring to metal/metalloid pollution and using integrated chemical, biochemical and biological approach, as well as to evaluate the risk for human health. In addition, it will contribute to development of water management plans and is therefore, of strategic importance for the Republic of Croatia. The proposed project will also provide capacity building of the next generation of scientists.]]></summary_en></project><project>
<id>2959</id><title_hr><![CDATA[ HIBRIBRIDNE SILICIJSKE NANOSTRUKTURE ZA SENZORIKU]]></title_hr><title_en><![CDATA[ HYBRID SILICON NANOSTRUCTURES FOR SENSING ]]></title_en><user_id>3688</user_id><user_firstLast_name>Mile Ivanda</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2014-09</proposal_call><code>IP-2014-09-7046</code><acronim><![CDATA[NANOSENS]]></acronim><duration>01.06.2015 - 31.05.2019</duration><status>Završio</status><financ_value>132.191,92 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, Kemija, </scie_field_hr><scie_field_en>Physics, Chemistry, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>5237, 5879, 4750, 4964, 5104, 4963, 4632, 4296, 5187, 5190, 13452, 13039, </team_members_id><team_members_names><![CDATA[Sanja Vidaček, Maurizio Ferrari, Vedran  Đerek, Lara Mikac, Ozren Gamulin, Marin Kosović, Vedran Đurina, Davor Ristić, Stjepan Lugomer, Tibor Janči, Niyazi Serdar Sariciftci, Marko Škrabić, ]]></team_members_names><keywords_hr><![CDATA[SILICIJ, NANOSTRUKTURE, SENZORI, HIBRIDNE KOMPONENTE, ORGANSKI POLUVODIČI]]></keywords_hr><keywords_en><![CDATA[SILICON, NANOSTRUCTURES, SENSORS, HYBRID COMPONENTS, ORGANIC SEMICONDUCTORS]]></keywords_en><summary_hr><![CDATA[Prijedlog projekta temelji se na našim prethodnim aktivnostima kojima smo naučili pripraviti kvalitetne uzorke nanostrukturiranog silicija. Razvili smo i ideje te stekli znanja i iskustvo za daljnje eksperimentalne tretmane uzoraka kako bi se razvila nova svojstava s ciljem veće konkurentnosti kod određenih primjena.  Projekt se bavi temeljnim fizikalnim i kemijskim svojstvima i primjeni hibridnih silicijevih nanostruktura pripravljanim elektrokemijskim jetkanjem i kemijskom depozicijom iz pare pod niskim tlakom (LPCVD). Projektni prijedlog sadrži četiri međusobno povezana istraživačka zadataka: silicijeve hibridne nanostrukture za plinske senzore;  vrlo osjetljivi detektori za infracrvenu svjetlost; površinski pojačana Ramanova spektroskopija (SERS) u prehrambenoj tehnologiji i sferni optički mikrorezonatori u molekulskoj detekciji. Predloženi zadaci projekta su međusobno povezani preko priprave hibridnih materijala na temelju jeftinog silicija kompatibilnog CMOS tehnologiji u svrhu razvoja navedenih primjena. Za realizaciju predloženih istraživačkih zadataka organiziran je istraživački tim od 14 istraživača (9 znanstvenika i 5 doktorandada) sa 2 znanstvena instituta, 2 fakulteta, 1 instituta u privatnom sektoru i 2 instituta iz inozemstva. Elektrokemijski procesi jetkanja će se koristiti za pripravu silicija s porama odgovarajućih veličina i volumena s mogućom kontrolom od nanometarske do mikrometarske veličine. Različite kemijske metode biti će primjenjene za funkcionalizaciju poroznih silicijevih struktura pri istraživanjima i razvoju detekcije plina, IR senzora i SERS spektroskopije. Nove silicijeve heterostrukture pripravljene LPCVD metodom na sfernim kvarcnim optičkim microrezonatorima istraživati će se obzirom na mogućnosti primjene u detekciji molekula. Strukturna, optička i elektronska svojstva predloženih funkcionalnih silicijskih nanostruktura istraživati će se sa gledišta temeljnih spoznaja kao i u svrhu razvoja specifičnih proizvoda visoke tehnologije potrebnih hrvatskoj industriji.]]></summary_hr><summary_en><![CDATA[The project proposal is based on our prior research activities where we learned how to prepare high quality nanostructured silicon. We have also developed ideas and gained knowledge and experience for further experimental treatments of our samples aimed on development of new properties competitive for specific applications. The project addresses fundamental physics and chemistry, properties and application of silicon hybrid nanostructures prepared by electrochemical anodisation and low pressure chemical vapour deposition (LPCVD). The project proposal consists of four interrelated research tasks: silicon/hybrid nanostructures for gas sensing; low light infrared detection; surface enhanced Raman spectroscopy (SERS) in food technology and spherical optical microresonators in low concentration molecular detection. The proposed tasks are mutually interconnected by the CMOS technology compatible materials production based on inexpensive silicon, and by the search for their specific advanced applications. For the achievement of the proposed research tasks we have organized a team of 14 researchers (9 scientists and 5 PhD students) from 2 scientific institutions, 2 faculties and 1 institution in the private sector and 2 renowned institutions from abroad. Electrochemical processes will be used for construction of tailored pore sizes and volumes in silicon that are controllable on the scale from nano- to micrometers. A number of suitable chemistries will be applied for the functionalization of porous Si surfaces for gas sensing, IR sensors and SERS spectroscopy. The novel silicon heterostructures deposited by the LPCVD method on silica spherical optical microresonators will be investigated for possible applications in molecular sensing. The structural, optical and electrical properties of such functional silicon nanostructures will be examined from the fundamental science point of view as well as for development of specific high-tech products needed by the Croatian industry. ]]></summary_en></project><project>
<id>2963</id><title_hr><![CDATA[Fenotipski i epigenetski odgovor na sušni stres i prilagodljivost populacija hrasta lužnjaka (Quercus robur L.) uzduž gradijenta zemljopisne širine.]]></title_hr><title_en><![CDATA[Phenotypic and Epigenetic Response to Drought Stress and Adaptability of Quercus robur L. Populations along a Latitudinal Gradient]]></title_en><user_id>11185</user_id><user_firstLast_name>Jozo Franjić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2014-09</proposal_call><code>IP-2014-09-4686</code><acronim><![CDATA[PerdaQuercus]]></acronim><duration>15.06.2015 - 14.06.2019</duration><status>Završio</status><financ_value>128.377,99 eur</financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Šumarstvo, </scie_field_hr><scie_field_en>Forestry, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet šumarstva i drvne tehnologije]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Forestry and Wood Technology]]></institution_en><team_members_id>11184, 11214, 11304, 44, 11167, 5275, 11179, 12638, 5607, </team_members_id><team_members_names><![CDATA[Željko Škvorc, Ida Katičić Bogdan, Daniel Krstonošić, Saša Bogdan, Krunoslav Sever, Mladen Ivanković, Martina Temunović, Ivica Čehulić, Maja Morić, ]]></team_members_names><keywords_hr><![CDATA[fenotipska plastičnost, genetska raznolikost, klimatske promjene, ekološka niša, pozadinski rub rasprostranjenosti]]></keywords_hr><keywords_en><![CDATA[phenotypic plasticity, genetic variability, climate change, ecological nishe, rear distribution edge]]></keywords_en><summary_hr><![CDATA[Hrast lužnjak (Quercus robur L.) je jedna od ekonomski najvrijednijih europskih vrsta šumskog drveća. To je ključna klimatogena vrsta u šumama visoke razine bioraznolikosti te stoga ima i neprocjenjivu ekološku i društvenu vrijednost. Opstanak populacija ove vrste u južnoj i jugoistočnoj Europi je ugrožen zbog predviđenih klimatskih ekstrema kao što su dugotrajne suše. Te populacije su dio tzv. &#39;&#39;pozadinskog ruba&#39;&#39; areala vrste, a njihov fenotipski odgovor i sposobnost prilagođavanja klimatskim promjenama nisu dovoljno istraživani. Istraživanje će se provesti na potomstvu i biljnim uzorcima iz europskih populacija uzorkovanih uzduž okolišnog gradijenta zemljopisne širine (sjever-jug). Žarište istraživanja bit će na populacijama iz južnog i jugoistočnog dijela rasprostranjenosti vrste. Cilj nam je usporediti prilagodljivost, epigenetski i fenotipski odgovor na sušni stres južnijih populacija s populacijama iz središnjeg i sjevernog dijela rasprostranjenosti.Glavni znanstveni ciljevi predloženog projekta su određivanje: 1) neutralne genetske raznolikosti i strukture odabranih populacija uzduž gradijenta zemljopisne širine; 2) njihove epigenetske raznolikosti i strukture; 3) njihovog epigenetskog odgovora na dugoročni sušni stres; 4) njihovog fiziološkog, fenološkog, morfološkog i biokemijskog (odnosno fenotipskog) odgovora na sušni stres; 5) njihove adaptivne genetske varijabilnosti, diferencijacije i fenotipske plastičnosti; 6) sadašnje ekološke niše i glavnih okolišnih varijabli koje određuju distribuciju ove vrste 7) buduće rasprostranjenosti vrste uvjetovane scenarijima klimatskih promjena na temelju modeliranja ekološke niše kao i koji će dijelovi sadašnje rasprostranjenosti biti zahvaćeni smanjenjem prikladnosti staništa; 8) razina prilagodljivosti istraživanih populacija usporedbom njihove adaptivne genetske varijabilnosti, fenotipske plastičnosti i epigenetskog odgovora.]]></summary_hr><summary_en><![CDATA[Pedunculate oak (Quercus robur L.) is one of the economically most valuable European forest tree species. It is the keystone climax species of forests which harbour high biodiversity and consequently has priceless ecological and social value. Survival of the specie’s populations in southern and southeastern Europe is endangered by predicted climate extremes such as prolonged drought. These populations are the “rear edge” of the species distribution range and their phenotypic response and adaptive capacity to climate change have not been well studied. Research will be carried out on progenies and plant samples derived from European populations sampled along a latitudinal environmental gradient. The focus of the research will be placed on populations from the southern and southeastern part of the specie’s distribution range. We aim to compare adaptability, epigenetic and phenotypic responses to drought stress of southernmost populations with the populations from the central and northern part of the specie’s distribution range.The main scientific objectives of the proposed project are to determine: 1) neutral genetic diversity and structure of selected pedunculate oak populations along a latitudinal gradient; 2) their epigenetic diversity and structure; 3) their epigenetic response to long-term drought stress; 4) their physiological, phenological, morphological, biochemical and growth (i.e. phenotypic) response to drought stress; 5) their adaptive genetic variability, differentiation and plasticity; 6) current ecological niche preferences and main environmental variables driving its distribution 7) its future distribution under climate change scenarios based on ecological niche modelling and which parts of the contemporary distribution will suffer from decreased habitat suitability induced by climate change; 8) levels of the studied populations adaptability by comparing their adaptive genetic variability, plasticity and epigenetic response.]]></summary_en></project><project>
<id>2964</id><title_hr><![CDATA[Istraživanje utjecaja otpadnih voda iz farmaceutskih industrija na sastav i profil antibiotičke rezistencije izloženih mikrobnih zajednica u slatkovodnim sedimentima]]></title_hr><title_en><![CDATA[Exploring the impact of wastewaters from pharmaceutical industries on the composition and antibiotic resistance profile of exposed microbial communities in freshwater sediments]]></title_en><user_id>12566</user_id><user_firstLast_name>Nikolina Udiković Kolić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2014-09</proposal_call><code>UIP-2014-09-9350</code><acronim><![CDATA[WINAR]]></acronim><duration>01.09.2015 - 31.08.2018</duration><status>Završio</status><financ_value>130.479,79 eur</financ_value><scie_area_hr>Biotehničke znanosti, Prirodne znanosti, </scie_area_hr><scie_area_en>Biotechnical sciences, Natural sciences, </scie_area_en><scie_field_hr>Biotehnologija, Kemija, Biologija, </scie_field_hr><scie_field_en>Biotechnology, Chemistry, Biology, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>6257, 12589, 12743, 3674, 4621, 18946, 18989, 21182, </team_members_id><team_members_names><![CDATA[Irena Vardić Smrzlić, Tamara Jurina, Fabienne Wichmann, Marijan Ahel, Ana Šimatović, Ana Bielen, Juan José González Plaza, Milena Milaković, ]]></team_members_names><keywords_hr><![CDATA[antibiotička rezistencija, mikrobne zajednice, farmaceutska industrija, otpadna voda, sediment, antibiotici, teški metali, rezistom]]></keywords_hr><keywords_en><![CDATA[antibiotic resistance, microbial communities, pharmaceutical industry, wastewater, sediment, antibiotics, heavy metals, resistome]]></keywords_en><summary_hr><![CDATA[Rastuća rasprostranjenost bakterija rezistentnih na antibiotike trenutno je jedna od najozbiljnijih prijetnji zdravlju. Istraživanja pokazuju da kontinuirani unos antibiotika i teških metala u okoliš doprinosi ovom problemu. Selekcijski pritisak nametnut od strane ovih zagađivala promovirao je razvoj i širenje antibiotičke rezistencije među okolišnim i patogenim bakterijama. Iako je otpad farmaceutske industrije prepoznat kao najvažniji točkasti izvor ovih zagađivala u prihvatnom vodenom okolišu, njegov utjecaj na sastav i profil antibiotičke rezistencije izloženih mikrobnih zajednica nije poznat. Kako bi popunili ovaj važan istraživački jaz, predlažemo primijeniti interdisciplinarni pristup koji će se fokusirati na slatkovodne sedimente koji su pod utjecajem otpadnih voda iz dviju lokalnih farmaceutskih industrija. Procijenit ćemo rasprostranjenost antibiotika i teških metala u tim sedimentima i identificirati potencijalne &#39;&#39;vruće točke&#39;&#39; za razvoj rezistencije. Geni koji kodiraju za antibiotičku rezistenciju porijeklom iz &#39;&#39;vrućih točaka&#39;&#39; i referentnih mjesta bit će otkriveni primjenom funkcionalne metagenomike. Ovaj pregled bit će osnova za kvantitativnu studiju koja će uspostaviti prostorno-vremensku poveznicu između industrijskog ispusta i zastupljenosti antibiotičke rezistencije. Ovi podaci, u kombinaciji sa hvatanjem rezistentnih plazmida direktno iz bakterija sedimenta u modelni patogen, bit će kritični za donošenje zaključaka o širenju rezistencije među bakterijama. Kompletno sekvenciranje mobilnih plazmida će nadalje pomoći u identifikaciji novih plazmida koji nose grupirane gene za rezistenciju na antibiotike i teške metale. Konačno, utjecaj ispusta na dinamiku sastava bakterijskih zajednica u sedimentima bit će analiziran Ilumina sekvenciranjem 16S rRNA gena. Vjerujemo da će dobivena saznanja imati vitalne implikacije na razvoj učinkovitih strategija upravljanja kako bi se smanjilo širenje antibiotika i antibiotičke rezistencije preko okolišnih puteva.]]></summary_hr><summary_en><![CDATA[The increasing prevalence of antibiotic resistant bacteria is currently one of the most serious health threats. There is growing evidence that continuous environmental discharge of antibiotics and heavy metals contributes to this issue. The selection pressure imposed by these pollutants has promoted the development and spread of antibiotic resistance among environmental bacteria and pathogens. Although pharmaceutical waste is recognized as the most important point source of these pollutants in the receiving aquatic environment, its impact on the composition and antibiotic resistance profile of exposed microbial communities is not known. To fill this important research gap, we propose to take an interdisciplinary approach focusing on freshwater sediments impacted by wastewaters of two local pharmaceutical industries. We will assess the prevalence of antibiotics and heavy metals in these sediments and identify potential hot spots for resistance evolution. Antibiotic resistance genes from hot spots and reference sites will be discovered using functional metagenomics. This will lay the groundwork for a quantitative study that will establish spatio-temporal relationships between industrial discharge and the occurrence of antibiotic resistance. This, in combination with direct capturing of resistance plasmids from sediment bacteria to a model pathogen will be critical to draw conclusions about the spread of resistance genes among bacteria. Complete sequencing of transferable plasmids will furthermore assist in identifying novel plasmids that carry clustered antibiotic and heavy metal resistance gene loci. Finally, the impact of discharge on dynamics of sediment community composition will be analyzed by Illumina sequencing of 16S rRNA genes. We believe that the obtained knowledge will have vital implications for the development of effective management strategies to reduce the spread of antibiotics and antibiotic resistance determinants via environmental pathways.]]></summary_en></project><project>
<id>2983</id><title_hr><![CDATA[Nutritivna modulacija metabolizma dokozaheksaenske kiseline kod dijabetičke dislipidemije]]></title_hr><title_en><![CDATA[Nutritive modulation of  docosahexaenoic acid metabolism in diabetic dyslipidemia]]></title_en><user_id>5392</user_id><user_firstLast_name>Tomislav Mašek</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2014-09</proposal_call><code>IP-2014-09-8992</code><acronim><![CDATA[dislipiDHA]]></acronim><duration>01.02.2016 - 31.01.2019</duration><status>Završio</status><financ_value>98.480,32 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Veterinarska medicina, </scie_field_hr><scie_field_en>Veterinary medicine, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Veterinarski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Veterinary Medicine]]></institution_en><team_members_id>12663, 3601, 3611, 12946, 6444, 12484, 13016, 5271, 12628, 13235, 3257, 12450, </team_members_id><team_members_names><![CDATA[Kristina Starčević, Marcela Šperanda, Mislav Đidara, Diana Brozić, Franjo Martinković, Krešimir Bošnjak, Maja Maurić, Snježana Kužir, Luka Krstulović, ivana stolić, Zvonko Stojević, Marina Vranić, ]]></team_members_names><keywords_hr><![CDATA[dokozaheksaenska kiselina, dislipidemija, dijabetes, peroksisomi, oksidacija, prehrana]]></keywords_hr><keywords_en><![CDATA[docosahexaenoic acid, dyslipidemia, diabetes, peroxisomes, oxidation, nutrition]]></keywords_en><summary_hr><![CDATA[Dokozaheksaenske kiseline (DHA) je važna masna kiselina čiji je biokemijski put sinteze  dugo vremena  bio nejasan. Trenutni model pretpostavlja kako nakon serije desaturacija i elongacija u endoplazmatskoj mrežici nastaje C24:6n3 koja odlazi u peroksisom gdje se jednim ciklusom ß-oksidacije skraćuje u 22:6n3 (DHA) i zatim odlazi natrag u endoplazmatsku mrežicu gdje bude esterificirana u odgovarajuće fosfolipide. Količinu DHA u plazmi i tkivima određuje unos masnih kiselina hranom, natjecanje za enzime između n3 i n6 linije masnih kiselina i endogeni metabolizam. Svi ovi čimbenici mogu biti promijenjeni tijekom dijabetesa. Međutim, složenost sinteze trenutno onemogućava točno predviđanje razine DHA u tkivima dijabetičnih životinja.   U projektu ćemo istražiti učinak n3/n6 omjera lipida hrane i direktnog dodatka DHA kod dijabetesa tipa 1 i 2 na metabolizam DHA, oksidaciju u mitohondrijima i peroksisomima i DHA metabolom. Naša pretpostavka je dokazivanje da hranidbena modulacija može umanjiti učinak inzulina kod dijabetičke dislipidemija što može imati veliko značenje u tretmanu dijabetesa. Dodatno ćemo istražiti koji enzimi, uključeni u mitohondrijsku i peroksisomsku   ß-oksidaciju, mogu biti regulirani lipidima hrane.          Istraživanja će biti provedena na štakorima kojima će biti induciran dijabetes tipa 1 i 2 te će dobivati hranidbene tretmane s varirajućih razinama n3/n6   i povećanom koncentracijom DHA. Integriranje rezultata pokusa objasnit će promjene u koncentracijama DHA kod različitih tipova dijabetesa. Istraživanja na subcelularnoj razini omogućit će utvrđivanje učinka dijabetesa na mitohondrijsku i peroksisomsku ß-oksidaciju i metabolizam DHA. Istraživanje metaboloma DHA povezat će prehranu, dijabetes i bioaktivne produkte DHA. Naposljetku, podaci iz cjelokupnog projekta rezultirat će integracijom znanja i boljim razumijevanjem biosinteze DHA.]]></summary_hr><summary_en><![CDATA[Docosahexaenoic acid (DHA) is an important fatty acid which biochemical pathway was enigmatic for a long time. Current model suggests that after the series of desaturation and elongation processes in endoplasmic reticulum C24:6n3 is synthesized, transported to the peroxisome and then shortened to 22:6n3 via one cycle of ß-oxidation and transported back to the endoplasmic reticulum for esterification into the appropriate phospholipids. Plasma and tissue DHA values are determined by dietary intake, competition for enzymes between n3 and n6 line and by the endogenous fatty acid metabolism, which could be dysregulated by diabetes. Nevertheless, the complexity of synthesis currently prevents correct prediction of DHA content in the tissues of diabetic animals.In this project, we will investigate the influence of n-3/n-6 ratio and DHA supplementation in insulin dependent and non-insulin dependent diabetes mellitus on DHA metabolism, mitochondrial and peroxisomal oxidation and DHA metabolome. Our assumption is that nutritional modulation can override insulin influence on diabetic dyslipidemia which could have profound influence on the treatment of diabetes. Additionally we will try to find enzymes of mitochondrial and peroxisomal ß-oxidation which could influence DHA metabolism by nutritional modulation. Trials will be performed on rats with induced diabetes which will receive dietary treatments with different n3/n6 ratios and increased DHA content. Integration of results from experiments will define the behavior of DHA in different types of diabetes. Investigations on subcellular level will allow us to determine the influence of diabetes on peroxisomal and mitochondrial beta oxidation and DHA metabolism. Investigation of DHA metabolome will link nutrition, diabetes and bioactive DHA products. Finally, data from the whole project will result in integration of knowledge and better understanding of DHA biosynthesis.]]></summary_en></project><project>
<id>2984</id><title_hr><![CDATA[Genski polimorfizmi i ishemijski moždani udar u djece]]></title_hr><title_en><![CDATA[Gene polymorphisms and ischemic stroke in children]]></title_en><user_id>3334</user_id><user_firstLast_name>Renata Zadro</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2014-09</proposal_call><code>IP-2014-09-2047</code><acronim><![CDATA[GENESTROKE]]></acronim><duration>01.10.2015 - 30.09.2019</duration><status>Završio</status><financ_value>106.103,92 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Farmaceutsko-biokemijski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Pharmacy and Biochemistry]]></institution_en><team_members_id>4701, 4057, 4032, 5252, 4686, 13580, 21314, 1302, </team_members_id><team_members_names><![CDATA[Marija Miloš, Margareta Radić Antolic, Ivana Horvat, Marina Pavić, Desiree Coen Herak, Jasna Leniček Krleža, Andrea Čeri, Vlasta Đuranović, ]]></team_members_names><keywords_hr><![CDATA[ishemijski moždani udar,  genski polimorfizmi, trombofilija, djeca, koagulacija]]></keywords_hr><keywords_en><![CDATA[ischemic stroke, genetic polymorphisms, thrombophilia, children, coagulation]]></keywords_en><summary_hr><![CDATA[Cerebrovaskularni poremećaji u djece, iako rijetki, rezultiraju značajnom smrtnošću i dugotrajnim morbiditetom. Pojavnost moždanog udara u djece prema podacima populacijskih studija iznosi 1,23-13,0/100.000 djece/godišnje. Iako je poznato više od 100 rizičnih faktora za nastanak moždanog udara, genetički faktori nisu potpuno istraženi. Za FV Leiden, FII 20210G>A, MTHFR677C>T, manjak protiena C i povišeni lipoprotein (a) pokazano je da igraju ulogu u moždanom udaru u djece. Moždani udar u djece vjerojatno nastaje kao posljedica interakcije više različitih gena i čimbenika okoliša koji zajedno s razlikama u cerebrovaskularnom, neurološkom i koagulacijskom sustavu ograničavaju izravnu ekstrapolaciju istraživanja s odraslih na djecu i opravdaju istraživanja polimorfizama ostalih trombofilijskih faktora. Cilj ovog istraživanja je odrediti prevalenciju genetičkih rizičnih čimbenika u skupini djece s ishemijskim moždanim udarom analizom polimorfizama u i) koagulacijskim faktorima FV (FV Leiden i FV H1299R), FII (20210G>A), FXIII (Val34Leu), beta-fibrinogen (-455G>A) i PAI-1 4G/5G; ii) trombocitni glikoproteinski receptori GPIa (807C>T/873G >A i 52T>C), GPIba (1018C>T, VNTR i (-5C/T Kozak), GPIIb/IIIa (1565T>C – PIA1/A2 i 2622T>G) i GPVI (13254T>C); iii) P-selektin (S290N, N562D, V599L, T715P) i iv) intermedijarni rizični faktori za moždani udar u djece, ACE I/D i Apo E2/E3/E4. Dobiveni rezultati unaprijedit će spoznaju o uključenosti ostalih genetičkih rizičnih čimbenika u etiologiji ishemijskog moždanog udara u djece. Razumijevanje genetičke osnove ishemijskog moždanog udara doprinijet će razvoju i primjeni standardiziranih protokola u dijagnostici, istraživanju, terapiji i procjeni ishoda moždanog udara u djece.]]></summary_hr><summary_en><![CDATA[Cerebrovascular disorders in children, although rare, result in significant mortality and long-term morbidity. The incidence of childhood stroke as reported by population based studies is 1.23-13.0/100 000 children/year. More than 100 risk factors for stroke are recognized but genetic factors are incompletely characterized. FV Leiden, FII 20210G>A, MTHFR 677C>T, protein C deficiency and elevated Lp(a) have been demonstrated to play a role in childhood stroke.  It is likely that stroke in children occurs secondary to interactions between several genes and the environment that, together with age-related differences in cerebrovascular, neurological and coagulation systems limit the direct extrapolation of research from adults to children and justify research of polymorphisms of other thrombophilic factors. The aim of this investigation is to determine the prevalence of genetic risk factors in a cohort of children with ischemic stroke by analysis of polymorphisms in i) coagulation factors FV (FV Leiden and FV H1299R), FII (20210G>A), FXIII (Val34Leu), ß-fibrinogen (-455G>A) and PAI-1 4G/5G; ii) platelet glycoprotein receptors GPIa (807C>T/873G>A and 52T>C), GPIba (1018C>T, VNTR and (-5)C/T Kozak), GPIIb/IIIa (1565T>C – PIA1/A2 and 2622T>G) and GPVI (13254T>C); iii) P-selectin (S290N, N562D, V599L, T715P) and iv) intermediate risk factors for childhood stroke, ACE I/D and Apo E2/E3/E4. The obtained results will enhance knowledge about involvement of other genetic risk factors in the etiology of ischemic stroke in childhood. The understanding of genetic basis of ischemic stroke will contribute to the development and application of standardized protocols for the diagnosis, investigation, therapy and outcome assessment of ischemic stroke in children.]]></summary_en></project><project>
<id>3000</id><title_hr><![CDATA[Definiranje mogućnosti uporabe mini dentalnih implantata (MDI) i njihovi rezultati u in vitro i u kliničkim prospektivnim istraživanjima]]></title_hr><title_en><![CDATA[Defining possibilities of using Mini dental implants (MDI) and their outcomes in vitro and in clinical randomised prospective studies]]></title_en><user_id>7709</user_id><user_firstLast_name>Asja Čelebić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2014-09</proposal_call><code>IP-2014-09-1218</code><acronim><![CDATA[Mini implantati/ MDI]]></acronim><duration>17.11.2015 - 01.09.2020</duration><status>Završio</status><financ_value>125.423,05 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Dentalna medicina, Kliničke medicinske znanosti, </scie_field_hr><scie_field_en>Dental medicine, Clinical sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu]]></institution_hr><institution_en><![CDATA[University of Zagreb]]></institution_en><team_members_id>13290, 13236, 7100, 11237, 13209, 13315, 13264, 13199, 13201, 5491, 6148, 13743, 21397, </team_members_id><team_members_names><![CDATA[Denis Vojvodić, Robert Ćelić, Amir Ćatić, Ketij Mehulić, Renata Poljak-Guberina, Dražan Kozak, Damir Modrić, Sanja Peršić, Josip Kranjčić, Goran Batinjan, Irina Filipović Zore, Nikola Petričević, Dino Buković, ]]></team_members_names><keywords_hr><![CDATA[Mini dentalni implantati, standardni implantati, mehanička teastiranja na modelima, klinička prospektivna istraživanja, određivanje indikacija za MDI]]></keywords_hr><keywords_en><![CDATA[Mini dental implants, standard implants, mechanical testing on models, clinical prospective studies, MDI indications]]></keywords_en><summary_hr><![CDATA[Mini dentalni implantati (MDI) su jednokomadni uski implantati za privremenu (ortodoncija, privremeni mostovi) ili za dugoročnu kliničku upotrebu. Prednosti MDI za trajnu kliničku primjenu su u njihovoj niskoj cijeni i jednostavnoj proceduri. Iako na dentalnom tržištu postoje već 10 godina, dokazi o budućim kliničkim istraživanjima za definiranje njihovih kliničkih protokola i njihovom dugoročnom ishodu nedostaju. Stoga planiramo istraživati njihova mehanička svojstva na modelima s obzirom na moment sile prilikom insercije, mogućnost loma prilikom cikličkih opterećenja ili  opterećenja prilikom naprezanja. Situacija slična stanju u ustima  će se simulirati pomoću različitih kosti tvrdoće modela (guste vs kosti niske gustoće) s 2 vrste sluznice  različite širine, te insercijom  1, 2, 3 ili 4 MDI različite širine i dužine za retenciju pokrovne proteze. 3 D printevi služiti će da bi se razvili modeli na kojima će se testirati. Nadalje, buduće kliničke studije koje će se temeljiti na pacijentovoj procjeni ishoda terapije (pomoću psihometrijski odobrenih upitnika) i kliničkih parametara (preživljavanje implantata, komplikacije, razina kosti oko implantata, resorpcija na stražnjim bezubim dijelovima ispod baze proteze, kortikalni indeksi na donjem rubu mandibule, vrijednosti gonion i antegonion udubina, gustoća kostiju u područjima interesa koji će biti izraženi u debljini stepwedga, mjerenje plak, gingiva i kalkulus indeksa, ISQ vrijednosti) će također biti predmetom istraživanja. Podaci će se upoređivati sa onima dobivenim nakon jedne i 3 godine.  Rezulati dobiveni temeljem pacijentove procjene usporediti će se s kliničkim dobivenim parametrima. Nadalje, rezultati dobiveni s obzirom na kliničke parametre kod pacijenata sa MDI (kvaliteta kostiju, količina, gustoća) će se uspoređivati sa podacima kod pacijenata sa potpunim protezama, kod pacijenata sa pokrovnim proteze na 2-standardna implantata te kod  osoba s prirodnim zubala. Također će se proučavati različite mogućnosti retencije proteza (mehanizmi).]]></summary_hr><summary_en><![CDATA[Mini dental implants (MDIs) are one piece slim implants for temporary (orthodontics, temporary bridges) or for a long term clinical use. Advantages of MDIs for a permanent clinical use are their low cost and simple procedures. Although they exist at the dental market for 10 years, evidence based prospective clinical studies for definition of their clinical protocols and long term outcomes are missing. Therefore we plan to study first their mechanical properties on models considering placement torque, fracture torque, possibility of fracture upon cycling loads or strain loads. A situation similar to real one will be simulated by using different bone hardness models (dense vs, low density bone) with 2 different oral mucosa widths, and with insertion of 1, 2, 3 or 4 MDIs of different width and length for overdenture retention. 3D prints will be helpful in model development. Further, prospective clinical studies based on both, patient based outcomes (assessed by psychometrically approved questionnaires) and clinical parameters (implant survival, any complications, bone level adjecent to implants, bone resorption at posterior edentulous sites under a denture base, cortical indices changes at the low border of the mandible, gonion angle and antegonion pitch values, bone density in the region of interest expressed as equvivalents of actual Cu stepwedge thickness attached during exposure, plaque, gingival and calculus indices, ISQ values) will be performed. Baseline data will be compared to a 1-year and 3-year outcomes. Patient based outcomes will be compared with clinical data. Results considering clinical parameters (bone quality, quantity, density) will be compared to similar data in complete denture wearers, in overdenture patients with dentures retained by 2-standard size implants and in individuals with natural dentition. Different denture retention options (mechanisms) will also be studied.]]></summary_en></project><project>
<id>3001</id><title_hr><![CDATA[Postimperijalni narativi u srednjoeuropskim književnostima moderne]]></title_hr><title_en><![CDATA[Postimperial narratives in Central European Literatures of the Modern Period]]></title_en><user_id>7997</user_id><user_firstLast_name>Marijan Bobinac</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2014-09</proposal_call><code>IP-2014-09-2307</code><acronim><![CDATA[Postimperial]]></acronim><duration>01.06.2015 - 31.05.2019</duration><status>Završio</status><financ_value>62.349,19 eur</financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Filologija, Povijest, </scie_field_hr><scie_field_en>Philology, History, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Filozofski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Humanities and Social Sciences]]></institution_en><team_members_id>12586, 3566, 12609, 12579, 6503, 21419, 17727, 25305, 25194, 25245, 17728, </team_members_id><team_members_names><![CDATA[Svjetlan Lacko Vidulić, Milka Car, Davor Dukić, Magerski Christine, Jelena Spreicer, Daniela Finzi, Endre Hars Hars, Wolfgang Müller-Funk, andrea seidler, Clemens Ruthner, Johann Georg Lughofer, ]]></team_members_names><keywords_hr><![CDATA[Postimperijalni narativi, srednjoeuropske književnosti: hrvatska, austrijska, mađarska, moderna, dihotomija centar/periferija, Habsburg postcolonial]]></keywords_hr><keywords_en><![CDATA[Postimperial narratives, Central European literatures: Croatian, Austrian, Hungarian, modern period, dichotomy center/periphery, Habsb. postcolonial]]></keywords_en><summary_hr><![CDATA[Naš projektni prijedlog, polazeći od teorijskog pristupa tzv. imperijalnih i postimperijalnih studija, istraživat će dodire i preklapanja u srednjoeuropskim kulturama sjećanja, a napose točke preklapanja u (zajedničkim) strukturama književne produkcije na tom području. Posebna će se pozornost pritom posvetiti Habsburškoj monarhiji, odnosno njezinim zemljama sljednicama u posljednjim dvama stoljećima, tj. u razdoblju od početaka procesa nastajanja modernih nacija pa sve do rasapa multietničkih državnih formacija, tj. starih imperija srednje i jugoistočne Europe, i nastanka novih nacionalnih država.Termin imperij, ključan pojam našeg istraživanja, preuzet je iz geopolitičke povijesti i može se primijeniti i na druge značajne državne strukture tog tipa (Osmansko, Rusko, Njemačko carstvo), relevantne u spomenutom vremenskom i prostornom kontekstu. Koncept implicira postojanje složene mreže društvenih, političkih i gospodarskih odnosa unutar tih državnih formacija, odnosa koji nastaju i posreduju se kroz konstrukcije &#39;kulturne razlike&#39; i asimetričnih odnosa moći. Imperij se može shvatiti kao kompleksna kulturna &#39;priča&#39; koju stvaraju političke i kulturne elite: kao neka vrsta narativnog konstrukta koji se u različitim kontekstima strukturira na različite načine, služeći pritom opisu ili objašnjenju određenih pojava ili odnosa. Stoga se ne samo nacionalne, nego i supranacionalne, tj. imperijalne kulture trebaju proučavati kao &#39;pripovjedne zajednice&#39;, strukture koje se međusobno razlikuju ponajprije po svome pripovjednom &#39;rezervoaru&#39;.Osnova istraživanja bit će književnost, kulturni medij koji raspolaže jedinstvenim mogućnostima reprezentacije, afirmacije i subverzije konstrukcija kulturnog sjećanja i procesa stvaranja individualnih i kolektivnih identiteta. U tom kontekstu posebna će pažnja biti posvećena sljedećim pitanjima: 1) kako procesi nacionalne homogenizacije i imperijalne težnje funkcioniraju u mediju književnosti, 2) na koji se način oni prožimlju i sukobljavaju, te 3) kako se oni pritom instrumentaliziraju za konkretne političke, ideološke ili estetske ciljeve.]]></summary_hr><summary_en><![CDATA[Our research project situates itself in the field of Imperial and Post-Imperial Studies. It will investigate overlaps and interferences between different cultures of memory in Central Europe, along with possible points of convergence in (joint) structures of literary production. Special attention will be paid to the Habsburg Monarchy and its successor states in the last two centuries – from the beginnings of the modern nation building process to the subsequent disintegration of multi-ethnic state formations.The term ‘empire’, being key to our research, is borrowed from geopolitical historiography and also applies to other empires in the region, which are relevant in the aforementioned temporal and spatial context. The concept implies a complex network of social, political and economic relations within the state, established and ‘translated’ through constructions of ‘cultural difference’ and asymmetrical power relations. Thus, ‘empire’ can also be understood as a complex cultural ‘story’ told by the political and cultural stakeholders: a type of narrative construct structured differently in different contexts and often used to describe or explain certain social / historical facts. Accordingly, not only national, but also supranational, i.e. imperial, cultures should be studied as ‘narrative communities’ differing from each other mainly through their cultural story-telling reservoirs.In order to exemplify this, our research project will be based on the study of literature as a medium of culture with the unique capacity to represent, affirm and undermine constructions of cultural memory and processes of both individual and collective identity formations. For conclusive results, we will address the following research questions: 1) how processes of national homogenization and imperial claims function in the medium of literature, 2) how they come in contact and, 3) how they can be instrumentalized for concrete political, ideological or aesthetic purposes.]]></summary_en></project><project>
<id>3002</id><title_hr><![CDATA[Imunosne i regenerativne implikacije korozije dentalnih materijala u djece i adolescenata]]></title_hr><title_en><![CDATA[Immunological and regenerative implications of corrosion of dental materials in children and adolescents ]]></title_en><user_id>77</user_id><user_firstLast_name>Stjepan Špalj</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2014-09</proposal_call><code>IP-2014-09-7500</code><acronim><![CDATA[IMUNODENT]]></acronim><duration>01.12.2015 - 30.11.2019</duration><status>Završio</status><financ_value>127.735,09 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo, Tehničke znanosti, </scie_area_hr><scie_area_en>Biomedicine and health sciences, Technological sciences, </scie_area_en><scie_field_hr>Dentalna medicina, Kemijsko inženjerstvo, Strojarstvo, Kliničke medicinske znanosti, Javno zdravstvo i zdravstvena zaštita, </scie_field_hr><scie_field_en>Dental medicine, Chemical engineering, Mechnical engineering, Clinical sciences, Public health and health services, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Medicine]]></institution_en><team_members_id>3799, 5203, 104, 99, 12407, 11286, 11287, 4798, 11283, 5125, 4260, 3866, 13366, 3810, 25209, </team_members_id><team_members_names><![CDATA[Zorana Ivanković Buljan, Helena Otmačić Ćurković, Magda Trinajstić Zrinski, Višnja Katić, Elitza Petkova Markova-Car, Aleksandar Bulog, Sandra Peternel, Koviljka Matušan Ilijaš, Ines Musa Trolić, Andrej Pavlić, Marijana Rinčić Mlinarić, Jelena Prpić, Jasmina Primožič, Miranda Muhvić Urek, Martina Žigante, ]]></team_members_names><keywords_hr><![CDATA[allergy, antibiotic resistance, nickel exposure, titan exposure, corrosion]]></keywords_hr><keywords_en><![CDATA[allergy, antibiotic resistance, nickel exposure, titan exposure, corrosion]]></keywords_en><summary_hr><![CDATA[Pomicanje zubi napravama baziranim na niklu i titanu ima veliki osteogeni potencijal i može regenerirati deficijentne dijelove alveolarne kosti i gingive te rehabilitirati narušene okluzijske odnose i žvačnu funkciju pacijenta. Zbog dugotrajnosti takve terapije paralelno se primjenjuju postupci i materijali za prevenciju te regeneraciju oštećene cakline i oralnih sluznica. Usna šupljina može se smatrati galvanskim člankom gdje su dentalne slitine elektrode, a elektrolit čine slina te oralni preventivni i regeneracijski agensi. Interakcija uzrokuje koroziju, smanjenje elastičnosti naprava, produkciju prevelikih sila, poremećaj regeneracije tikiva i nepopravljive štete na korijenu zuba, parodontu i kosti. Tijekom dugotrajne eksponiranosti otpušteni korozivni produkti u okolnim tkivima te transportirani slinom i krvlju mogu izazvati cijeli niz nusefekata. Alergije su danas sve češće i javljaju se sve ranije, a posebna skupina su djeca i mladi adolescenti u periodu pubertetskog rasta kada se razvija i imunološki sustav. Nikal je dugo poznati alergen i prisutan je u brojnim dentalnim legurama. Alergija na nikal događaje su u do 28.5% populacije i ne može se više smatrati niskim potencijalnim rizikom. U posljednje vrijeme reportira se i alergija na titan, za koji se smatralno da je biokompatibilan, a izloženi su mu brojni pacijenti s endoprotezama kuka, stentovima, dentalnim implantatima i ortodontskim napravama. Alergija na titan može biti odgovorna za neobjašnjene slučajeve neuspjeha i odbacivanja dentalnih implantata. Nikal i titan mogu uzrokovati rezistenciju bakterija na antibiotike što može stvarati probleme u terapiji niza infekcija koje su češće u djece i adolesceanta. Cilj je ovog projekta ispitati u kojoj mjeri i kojim mehanizmima korozija dentalnih materijala baziranih na niklu i titanu izaziva prethodno navedene biološke učinke.]]></summary_hr><summary_en><![CDATA[Tooth movement, based on nickel-titanium appliance, has great osteogenic potential, it can regenerate deficient alveolar bone sites and gingiva, rehabilitate deficient occlusal relationships and masticatory function. Due to prolonged therapy materials and techniques for prevention and regeneration of damaged enamel and oral tissues are concurrently used. Oral cavity can be considered as a galvanic cell, where saliva is electrolyte and dental alloys and oral agents are galvanic coupling components. Decreasing elasticity of orthodontic wires due to intraoral corrosion can produce excessive forces and therefore can disturb regeneration of tissues and irreparable damage to root and surrounding periodontium and bone. Due to long-term exposure corrosive products are released into adjacent tissues, saliva and blood. There from a number of undesired side effects can develop. Nowadays, the allergies occur more often and onset earlier during a lifetime. Children and young adolescents are undergoing pubertal growth, changes and maturation of immune system and particular attention should be paid to their exposure. Nickel has been well known allergen, present in many dental alloys. Nickel allergic hypersensitivity occurs in up to 28.5% of the population and it cannot be considered a low potential risk. Lately, allergic reactions to titanium were reported in patients with endoprosthesis and dental implants, contrary to the previously established biocompatibility. The occurrence of an allergy to titanium could be responsible for successive unexplained cases of failure of dental implants. Nickel and titan can enhance resistance of some bacteria to antibiotics which can produce problems in treatment of several infections that are more common in children and adolescents. The aim of this project is to explore to what extent and by which mechanisms does corrosion of dental materials based on nickel and titan produce above mentioned biological effects.]]></summary_en></project><project>
<id>3004</id><title_hr><![CDATA[Razvoj evolucijskih postupaka za karakterizaciju ponašanja bioloških tkiva]]></title_hr><title_en><![CDATA[Development of evolutionary procedures for characterization of biological materials behavior]]></title_en><user_id>11229</user_id><user_firstLast_name>Marina Franulović</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2014-09</proposal_call><code>IP-2014-09-4982</code><acronim><![CDATA[BIOMAT]]></acronim><duration>01.10.2015 - 30.09.2019</duration><status>Završio</status><financ_value>95.228,62 eur</financ_value><scie_area_hr>Tehničke znanosti, Biomedicina i zdravstvo, </scie_area_hr><scie_area_en>Technological sciences, Biomedicine and health sciences, </scie_area_en><scie_field_hr>Strojarstvo, </scie_field_hr><scie_field_en>Mechnical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Tehnički fakultet]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Engineering]]></institution_en><team_members_id>12834, 12813, 12820, 13022, 13078, 13011, 13337, 22633, 24813, </team_members_id><team_members_names><![CDATA[Robert Basan, Kristina Marković, Tea Marohnić, Ivan Prebil, Ana Trajkovski, Senad Omerović, Simon Krašna, Stjepan Piličić, Robert Kunc, ]]></team_members_names><keywords_hr><![CDATA[biološki materijali, karakterizacija materijala, materijalni model, materijalni parametri, genetski algoritam]]></keywords_hr><keywords_en><![CDATA[biological materials, material characterization, material model, material parameters, genetic algorithm]]></keywords_en><summary_hr><![CDATA[U inženjerstvu sve se veća pažnja posvećuje poboljšanju značajki konvencionalnih i razvoju inovativnih materijala. Iako je istraživanje materijala uvelike usmjereno na metale, polimere, staklo, keramiku, kompozite itd., sve veći interes posvećuje se biološkim sustavima i materijalima (školjke, kosti, paukova svila, mišići itsl.) zbog njihovih svojstava koje uvelike nadvisuju one konvencionalnih materijala. Ponašanje i modeliranje bioloških materijala je kompleksno, ali se kao i modeliranje konvencionalnih materijala bazira na poznavanju i eksperimentalnom određivanju njihovih karakteristika. Pored materijalnog modela za opisivanje ponašanja materijala, osnovni preduvjet za modeliranje je identifikacija materijalnih parametara. Prethodno je ustanovljeno da je za identifikaciju parametara bioloških materijala potrebnih za modeliranje njihovog ponašanja preporučljivo primijeniti evolucijske metode, a posebno genetski algoritam. U okviru projekta karakterizirat će se i modelirati ponašanje vratnih ligamenata ljudske kralježnice na osnovi podataka dobivenih eksperimentima. Odabran je hiperelastični materijalni model koji se može koristiti i za kompresibilne i nekompresibilne materijale. Kako bi se na što efikasniji način dobile potrebne vrijednosti materijalnih parametara, razvit će se tehnika određivanja parametara temeljena na genetskom algoritmu. U cilju optimizacije procedure dobivanja parametara zadanog materijala, razvit će se procedura složenog genetskog algoritma te njegovi operatori, uz primjenu adekvatne funkcije cilja optimizacijskog postupka.Zbog fleksibilnosti i robusnosti predložene metodologije karakterizacije materijala, moguća je njena primjenjivost i na karakterizaciju ponašanja i drugih nekonvencionalnih i inovativnih materijala kompleksnog ponašanja. U tu svrhu prikupit će se i sistematizirati rezultati relevantnih publiciranih eksperimentalnih ispitivanja materijala te stvoriti pretpostavke za karakterizaciju drugih inovativnih materijala.]]></summary_hr><summary_en><![CDATA[In engineering great attention is paid to enhancing the properties of conventional and development of innovative materials. Although the research is largely focused on metals, polymers, glass, ceramics, composites, etc.., increasing interest is devoted to biological systems and materials (shells, bone, spider silk, muscle or similar) due to their characteristics that are significantly above those of conventional materials.Behavior and modeling of biological materials is complex, but as the modeling of conventional materials, it is based on the knowledge and experimental determination of their characteristics. To describe the behavior of materials, beside material model, the basic prerequisite is the identification of material parameters.It was found that for the identification of parameters of biological materials necessary for the modeling of their behavior, it is advisable to apply the evolutionary methods, especially genetic algorithm.In the project, the behavior of the neck ligaments of human spine will be characterized and modelled based on data obtained by experiments. A hyperelastic material model that can be used for compressible and incompressible materials is selected for that puprose. In order to more efficiently produce the required values of material parameters, a technique for determining the parameters based on genetic algorithm will be developed. In order to optimize the procedure to obtain the parameters specified materials, complex genetic algorithm and its operators will be developed, applying the appropriate objective function optimization procedure.Because of it&#39;s flexibility and robustness, the proposed methodology for the materials characterization is expected to be applicable to the characterization of other non-conventional and innovative materials of complex behavior. To this end, relevant published experimental results will be collected and systematized in order to create the basis for the characterization of other innovative materials.]]></summary_en></project><project>
<id>3005</id><title_hr><![CDATA[Molekularni mehanizmi ugradnje homolognih i heterolognih proteina u staničnoj stijenci kvasca i njihova primjena u biotehnologiji]]></title_hr><title_en><![CDATA[Molecular mechanisms for incorporation of homologous and heterologous proteins in the yeast cell wall and their application in biotechnology]]></title_en><user_id>359</user_id><user_firstLast_name>Vladimir Mrša</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2014-09</proposal_call><code>IP-2014-09-2837</code><acronim><![CDATA[CEWAPROT]]></acronim><duration>01.09.2015 - 31.08.2019</duration><status>Završio</status><financ_value>122.834,96 eur</financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Biotehnologija, </scie_field_hr><scie_field_en>Biotechnology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prehrambeno-biotehnološki fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Food Technology and Biotechnology]]></institution_en><team_members_id>3258, 4377, 5726, 3284, 4764, 12966, 4031, 13195, 13087, 25089, </team_members_id><team_members_names><![CDATA[Renata Teparić, Igor Stuparevic, Slobodan Barbarić, Iva Grabarić Andonovski, Damir Iveković, Marina Palčić, Antonija Grbavac, Ksenija Lopandić, Krešimir Gjuračić, Mateja Lozančić, ]]></team_members_names><keywords_hr><![CDATA[stančna stijenka kvasca, proteini stanične stijenke, lokalizacija proteina, heterologna ekspresija, izlaganje na staničnoj površini, genetička imobili]]></keywords_hr><keywords_en><![CDATA[yeast cell wall, cell wall proteins, protein localization, heterologous expression, surface display, genetic immobilization]]></keywords_en><summary_hr><![CDATA[Stanična stijenka kvasca sastoji se od unutrašnjeg sloja glukana na koji su s vanjske strane vezani manoproteini. Velika je raznolikost među proteinima stijenke, ne samo u strukturama i aktivnostima, nego i u načinu na koji su ugrađeni u stijenku. Neki od njih vezani su nekovalentno, neki kovalentno putem esterske veze nestabilne u lužinama, a neki također kovalentno, ali putem GPI-sidra i beta-1,6-glukana. Za najzastupljeniji nekovalentno vezani protein, Scw4p, nađeno je da je na glukan djelomično vezan i kovalentno, još nepoznatom vrste veze. Jedan od ciljeva ovog projekta je objasniti molekularnu prirodu te veze. Osim toga, za nekoliko proteina stijenke, uključujući i Scw4p nađeno je da su proteolitički procesirani. Drugi cilj ovog projekta bio bi ispitati koje proteaze cijepaju Scw4p i koji je fiziološki značaj te modifikacije.Poznavanje mehanizama ugradnje proteina u stijenku kvasca upotrijebit će se za ugradnju i izlaganje na površini heterolognih proteina eksprimiranih u kvascu. Pripremit će se novi plazmidi u tu svrhu, za ekspresiju i ugradnju proteina u stijenku kvasaca S. cerevisiae i P. pastoris. Analizirat će se i stanične stijenke više drugih kvasaca izoliranih iz različitih habitata kako bi se ispitala mogućnost da oni budu novi domaćini za izlaganje proteina.Kako već postojeći, tako i novoistraženi genetički sustavi upotrijebit će se za izlaganje na površini šest enzima biokemijskog puta za degradaciju S-triazina iz bakterije Pseudomonas ADP. Istražit će se primjena dobivenih kvaščevih sojeva za degradaciju ovog široko korištenog herbicida.Druga potencijalna primjena ove metodologije obuhvatit će izlaganje nekoliko ksiloza reduktaza iz različitih kvasaca i primjenu dobivenih sojeva u proizvodnji ksilitola iz ksiloze uz odgovarajuću elektrokemijsku regeneraciju potrebnog NAD(P)H. Ispitat će se i potencijal te metode za primjenu u biosenzorima.]]></summary_hr><summary_en><![CDATA[Yeast cell wall consists of an inner layer of beta-1,3-glucan to which mannoproteins are attached. There is a pronounced variability among yeast cell wall proteins not only in their structures and activities, but also in the way they are incorporated into the wall. Some of them are attached non-covalently, some are linked covalently through an alkali labile ester linkage, and some are attached through GPI anchors and beta-1,6-glucan. The most abundant non-covalently attached protein Scw4p was found to be partly also covalently attached to glucan by a so far unknown linkage. One of the goals of this project is to explain the molecular nature of this linkage. Several cell wall proteins including Scw4p were found to be proteolytically processed. The second goal of the proposed project is to investigate which protease cleaves Scw4p and what is the physiological significance of this modification.Our comprehension of molecular mechanisms for incorporation of proteins in the yeast cell wall can be used for surface display of heterologous proteins expressed in yeasts. New plasmids will be created for this purpose for expression and wall incorporation of proteins in S. cerevisiae and P. pastoris. Besides, cell walls of several other non-Saccharomyces yeasts isolated from different habitats will be analysed to search for other potential hosts for surface display of proteins.Both existing, and newly investigated genetic systems will be used for surface display of six enzymes of the S-triazine complete degradation pathway from Pseudomonas ADP. Application of obtained strains in degradation of this world-wide commonly used herbicide will be explored. Described methodology would be used for surface display of several xylose reductases from several yeasts and the application of the obtained strains for enzymatic production of xylitol, combined with electrochemical regeneration of the necessary NAD(P)H. Potential of this method for application in biosensing will also be explored.]]></summary_en></project><project>
<id>3007</id><title_hr><![CDATA[Motorička znanja djece predškolske dobi: Osnivanje Nacionalnog centra za motorički razvoj]]></title_hr><title_en><![CDATA[Motor skills in preschool children: Foundation of the National center for motor development]]></title_en><user_id>12537</user_id><user_firstLast_name>Sanja Šalaj</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2014-09</proposal_call><code>UIP-2014-09-5428</code><acronim><![CDATA[MZDPD]]></acronim><duration>01.09.2015 - 31.08.2019</duration><status>Završio</status><financ_value>18.196,30 eur</financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Kineziologija, </scie_field_hr><scie_field_en>Kinesiology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Kineziološki fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Kinesiology]]></institution_en><team_members_id>12731, 12593, 7521, 1493, 13377, 13467, 4051, </team_members_id><team_members_names><![CDATA[Vatroslav Horvat, Milivoj Jovancevic, MAJA VUKELJA, Frane Žuvela, Dragan  Milanović, Biljana Trajkovski, Vilko Petrić, ]]></team_members_names><keywords_hr><![CDATA[temeljna kretna znanja, sposobnost, tjelesna aktivnost, vrtić, vježbanje ]]></keywords_hr><keywords_en><![CDATA[fundamental movement, physical abilities, toddler, exercise, physical activity, kindergarten]]></keywords_en><summary_hr><![CDATA[Kompetencija u području temeljnih motoričkih znanja poput trčanja, skakanja i bacanja pridonosi dječjem tjelesnom, kognitivnom i socijalnom razvoju i smatra se temeljem za aktivan život. Pozitivno je povezana sa zdravstvenim dobrobitima, razinom tjelesne aktivnosti djece, a negativno s nepovoljnim težinskim statusom: prekomjernom težinom i pretilošću (Lubans i sur., 2010).  cilj ovog projekta je osnivanje Nacionalnog centra za motorički razvoj pri Kineziološkom fakultetu Sveučilišta u Zagrebu. Postavljeni su znanstveni ciljevi i projektni zadaci po godinama koji će omogućiti: a) vrednovanje motoričkih znanja djece predškolske dobi u Republici Hrvatskoj, b) utvrđivanje razlika u motoričkim znanjima djece različitog stupnja tjelesne aktivnosti i uključenosti u programe vježbanja, c) definiranje povezanosti motoričkog razvoja sa ostalim domenama razvoja djeteta (socioemocionalni i govorno-jezični razvoj), d) utjecaj roditeljskog interesa prema sportu i stupnja njihove tjelesne aktivnosti na razinu motoričkih znanja djece i e) utvrđivanje utjecaja različitih trenažnih programa na motorička znanja i sposobnosti djece predškolske dobi. U istraživanju će sudjelovati 1500 dječaka i djevojčica u rasponu od 3 do 7 godina i njihovi roditelji iz različitih dijelova Republike Hrvatske. Mjerenje će se provoditi u dva dijela. Prvi dio predstavlja ispunjavanje anketnog upitnika od strane roditelja, a drugi dio testiranje motoričkih znanja putem dva seta testova za procjenu motoričkog statusa (“Test of Gross Motor Development“ i ˝Bruininks-Oseretsky Test of Motor Proficiency˝). Dobiveni podaci predstavljali bi temelj za definiranje normativnih vrijednosti i daljnja istraživanja motoričkog statusa djece u Republici Hrvatskoj te izradu strategije poticanja motoričkog razvoja kroz različite programe i znanstvene aktivnosti utemeljenog Nacionalnog centra za motorički razvoj.]]></summary_hr><summary_en><![CDATA[Competence in the field of fundamental movement skills such as running, jumping and throwing contributes to children&#39;s physical, cognitive and social development. It is considered to be the basis for an active lifestyle. Motor proficiency is positively associated with health benefits, level of physical activity of children, and negatively associated with body weight status (obesity) (Lubans et al., 2010). Final objective of this project is the establishment of the Croatian National Centre for Motor Development at the Faculty of Kinesiology, University of Zagreb. The set of scientific objectives and project assignments per year will allow: a) the evaluation of motor skills of preschool children in the Republic of Croatia, b) the determination of differences in motor skills of preschool children who are involved in different degrees of physical activity and exercise programs, c) the definition of the connection of motor development with the other domains of children development (socio-emotional and language), d) the determination of impact of parental interests in sports and  their physical activity levels on children&#39;s motor skills, and e) the assessment of different training programs effects on motor skills and abilities of preschool children. The study will embrace 1,500 boys and girls aged 3 to 7 years and their parents from different areas of the Republic of Croatia. Subjects’ testing will be conducted in two parts. First, the parents will fill out the questionnaire, and second, the children’s motor skills will be measured through two sets of motor development and motor proficiency tests. The resulting data would represent a foundation for the normative values and further research on motor status of children in the Republic of Croatia. Also, the findings will be the starting point for the development of strategies promoting motor development through various programs and research activities of the newly established Croatian National Center for Motor Development.]]></summary_en></project><project>
<id>3009</id><title_hr><![CDATA[Profesionalizam u zdravstvu]]></title_hr><title_en><![CDATA[Professionalism in Health Care]]></title_en><user_id>776</user_id><user_firstLast_name>Ana Marušić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2014-09</proposal_call><code>IP-2014-09-7672</code><acronim><![CDATA[ProHealth]]></acronim><duration>01.10.2015 - 30.09.2019</duration><status>Završio</status><financ_value>99.655,58 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Javno zdravstvo i zdravstvena zaštita, Kliničke medicinske znanosti, </scie_field_hr><scie_field_en>Public health and health services, Clinical sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Splitu, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Split School of Medicine]]></institution_en><team_members_id>1016, 2713, 772, 12675, 5404, 874, 12670, 767, 4435, 12768, 5258, 12730, 937, 1046, 4935, 777, 4510, 1418, 25225, </team_members_id><team_members_names><![CDATA[Lana Barać, Ana Jerončić, Mario Malički, Julije Meštrović, Tina Poklepović Peričić, Shelly Melissa Pranić, Dario Sambunjak, Davorka Vrdoljak, Elizabeth Wager, Ivančica Pavličević, Davor Lukšić, Karmela Krleža-Jerić, Ana  Utrobičić, Irena Zakarija-Grković, Dalibora Behmen, Matko Marušić, Livia Puljak, Darko Hren, Marin Viđak, ]]></team_members_names><keywords_hr><![CDATA[profesionalizam, zdravstvena skrb, profesionalci, integritet, izvrsnost, odgovornost, transparencija]]></keywords_hr><keywords_en><![CDATA[professionalism, health care, students, professionals, integrity, excellence, accountability, transparence]]></keywords_en><summary_hr><![CDATA[Predloženi projekt ima za cilj istraživanje izvrsnosti, odgovornosti i integriteta/transparencije kao atributa profesionalizma koji su relevantni za zdravstvenu skrb utemeljenu na dokazima, gdje je profesionalizam široko definiran kao predanost izvršavanju profesionalne zadaća, pridržavanju etičkih principa i osjetljivosti za pacijentovu dobrobit. Prva istraživačka tema projekta usmjerena je na profesionalizam u studenata. Istražit ćemo determinante profesionalnog razvoja studenata, kao i okružje za razvoj profesionalne izvrsnosti i integriteta. Temeljem nalaza iz tog dijela istraživanja, razvit ćemo i testirati intervencije za poticanje razvoja profesionalizma tijekom studija. Druga istraživačka tema usmjerena je na profesionalizam u praksi zdravstvene skrbi. Prvo ćemo usporediti okvire za profesionalnu izvrsnost i integritet, uključujući i dokaze dostupne zdravstvenim profesionalcima i njihovu translaciju u praksi. Temeljem nalazi iz tog dijela istraživanja, razvit ćemo i testirati intervencije za poboljšanje profesionalne prakse. Pristup svakom specifičnom cilj istraživanja uključit će 1) mapiranje trenutnog znanja i identifikacija područja s manjkavim znanjem, 2) uporabu adekvatnih istraživačkih ustroja i metodologija, 3) sinteza rezultata istraživanja u eksplanatorne teorije i modele i 4) razvoj i diseminacija aplikacija važnih za javnu politiku i pristup zdravstvenoj skrbi. Rezultati predloženih istraživanja pridonijet će boljem razumijevanju kako se profesionalizam razvija tijekom obrazovanja i prakse u zdravstvenoj skrbi. Razvojem i testiranjem novih intervencija za poticanje razvoja profesionalizma, projekt će donijeti dokaze za promicanje kurikularnog i cjeloživotnog učenja i za promjenu politike zdravstvene skrbi, kao i donijeti važne ekonomske i javnozdravstvene koristi.]]></summary_hr><summary_en><![CDATA[The proposed project aims to study excellence, accountability and integrity/transparency as attributes of professionalism which are most relevant for evidence-based healthcare, where professionalism is broadly defined as commitment to carrying out professional responsibilities, adherence to ethical principles and sensitivity to patient populations. The first research theme addresses professionalism in healthcare students. We will investigate the determinants of professional development in students, as well as the environment for the development of professional excellence and integrity. Based on the findings from this research, we will develop and test interventions for teaching professionalism in health curricula. The second research theme addresses professionalism in healthcare practice. We will first describe the framework for professional excellence and integrity, including the evidence available to healthcare practitioners and its translation to practice. Based on research results, we will develop and test interventions for professional practice. Each specific objective will include: 1) mapping of current research results and identification of knowledge gaps, 2) using appropriate research design and methodology, 3) synthesising research results into explanatory theories and models, and 4) developing and disseminating applications relevant for policy and public use. Results from the proposed research will contribute to better understanding of how professionalism develops during healthcare education and practice. By developing and testing new interventions for professionalism, the project will provide evidence for the advancement of curricular and life-long learning and policy changes in healthcare, as well as bring important economic and public health benefits.]]></summary_en></project><project>
<id>3010</id><title_hr><![CDATA[Model mjerenja efikasnosti javno zdravstvenih usluga]]></title_hr><title_en><![CDATA[A model for measuring the efficiency of public health services]]></title_en><user_id>245</user_id><user_firstLast_name>Neda Vitezić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2014-09</proposal_call><code>IP-2014-09-8235</code><acronim><![CDATA[MEPHS]]></acronim><duration>19.05.2015 - 18.05.2020</duration><status>Završio</status><financ_value>38.114,77 eur</financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Ekonomija, </scie_field_hr><scie_field_en>Economy, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Ekonomski fakultet]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Economics and Business]]></institution_en><team_members_id>5114, 7120, 6438, 13419, 6371, 13765, 6723, 22832, 4913, 5391, 25556, 1068, 22489, </team_members_id><team_members_names><![CDATA[Vladimir Mićović, Đulija Malatestinić, Lidija Pavica Pernar, Mirjana Grčić Fabić, Mirjana Zukić, Stanka Setnikar Cankar, Alemka Šegota, Antonija Petrlić, Suzana Janković, Danijela Rabar, Danijela Čošić, Željko Linšak, Ana Bobinac, ]]></team_members_names><keywords_hr><![CDATA[javno zdravstvene usluge, efikasnost, mjerenje, DEA,BSC]]></keywords_hr><keywords_en><![CDATA[public health services, efficiency, measurement, DEA, BSC]]></keywords_en><summary_hr><![CDATA[Predmet istraživanja je mjerenje efikasnosti javno zdravstvenih usluga u Hrvatskoj koje se provodi kroz razne programe i projekte zavoda za javno zdravstvo (prevencija bolesti, ekologija, socijalna medicina, mikrobiologija i sl.). Osnovni cilj istraživanja je predložiti model za mjerenje efikasnosti tih usluga a koji bi bio primjenjiv i na ostale usluge u zdravstvu ali i na druge javne usluge. (npr. u bolnicama, lokalnoj samoupravi, sveučilištu i sl.). Model će se temeljiti na kombinaciji dviju metoda (DEA-BSC) koje su pogodne za mjerenje efikasnosti i efektivnosti raznovrsnih javnih usluga. DEA metoda se tradicionalno koristi za neprofitne organizacije gdje slične organizacijske jedinice djeluju s različitim ulaznim/izlaznim veličinama i gdje u pravilu nema zarade. BSC je metoda kojom se potiče strateško razmišljanje i ocjenjuje učinkovitost postavljenih ciljeva. Kombinacija DEA i BSC metode je relativno nova ideja i koristi se za utvrđivanje uzročno posljedičnih veza posebno kod neefikasnih jedinica. Model će se razraditi na primjeru Nastavnog zavoda za javno zdravstvo Primorsko goranske županije koje ima 48 organizacijskih jedinica. Ciljevi projektnog prijedloga su sljedeći: utvrditi relativnu efikasnost svake organizacijske jedinice i predložiti poboljšanja za neefikasne organizacijske jedince (projekcija na efikasnu granicu–DEA metoda), definirati cjelovit model (integracija DEA i BSC) za mjerenje efikasnosti po pojedinim perspektivama unutar BSC okvira sa svrhom mjerenja efektivnosti ostvarivanja postavljenih ciljeva. ]]></summary_hr><summary_en><![CDATA[The subject of this research is to measure the efficiency of public health services in Croatia, which is carried out through various programs and projects of Public Health Institutes (prevention of diseases, ecology, social medicine, microbiology, etc.). The main goal of the research is to propose a model of measuring the efficiency of public health services that can also be applied to other activities in healthcare and other public services such as local government, universities etc. The model will be based on the combination of two methods (DEA and BSC) that are suitable for measuring the efficiency and effectiveness of various public services. DEA method is traditionally used for non profit organizations where similar units operate with different input/output basically without any income. BSC is a method that encourages strategic thinking and evaluates the effectiveness of set goals. The combination of DEA and BSC is relatively a new approach and is used to identify the cause and effect relationships especially within inefficient units. The model will be developed for the Teaching Institute of the Public Health of Primorje-Gorski Kotar County which has 48 organization units (DMUs). The objective of the project proposals are as follows: to determine relative efficiency of each organization unit and suggest improvements for the inefficient ones (projection on the efficient frontier-DEA method), to define an integrative model (integration of DEA and BSC) for measuring the efficiency of individual perspectives within BSC framework with the aim to assess the effectiveness of achieving goals. ]]></summary_en></project><project>
<id>3011</id><title_hr><![CDATA[Esencijalni metalni ioni u proteinima iz Helicobacter pylori i modelnim spojevima - struktura i funkcija/svojstvo]]></title_hr><title_en><![CDATA[Essential metal ions in Helicobacter pylori proteins and model complexes – structure and function/property]]></title_en><user_id>593</user_id><user_firstLast_name>Dubravka Matković-Čalogović</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2014-09</proposal_call><code>IP-2014-09-4274</code><acronim><![CDATA[ProtModStruct]]></acronim><duration>01.06.2015 - 31.05.2019</duration><status>Završio</status><financ_value>128.741,12 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, </scie_field_hr><scie_field_en>Chemistry, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>1141, 358, 946, 4525, 4656, 12917, 11285, 3347, 1186, 3993, 3414, 4657, 19005, 20946, 19876, </team_members_id><team_members_names><![CDATA[Draginja Mrvoš-Sermek, Biserka Prugovečki, Ivica Đilović, Nenad Judaš, Ivana Biljan, Neven Smrečki-Lolić, Marijana Marković, Marina Tašner, Ivana Pulić, Giuseppe Zanotti, Janez Plavec, Dalibor Milić, Darko Vušak, Kristina Smokrović, Mario Kekez, ]]></team_members_names><keywords_hr><![CDATA[essential metals, model compounds, structural characterization, H. pylori proteins, chemical synthesis]]></keywords_hr><keywords_en><![CDATA[esencijalni metali, modelni spojevi, strukturna karakterizacija, proteini iz H. pylori, kemijska sinteza]]></keywords_en><summary_hr><![CDATA[U okviru istraživanja na ovom projektu želimo strukturno karakterizirati nekoliko proteina iz Helicobacter pylori (i odrediti njihovu funkciju) kao i modelne komplekse malih molekula sa esencijalnim metalnim ionima i biološki važnim ligandima (i odrediti njihova svojstva). Prioritetni će biti metali koji se nalaze u metaloproteinima iz H. Pylori.Svjetska zdravstvena organizacija proglasila je H. Pylori karcinogenom 1. klase te je važna meta istraživanja zbog svoje patogenosti. Proteini HypA i HypB su važni za pravilnu konstrukciju metalnog centra [Ni,Fe] hidrogenaze i urease. Proteini CrdA i CrdB potrebni su za održavanje koncentracije slobodnih iona bakra u citoplazmi ispod toksične razine. Namjeravamo klonirati, eksprimirati, pročistiti i karakterizirati kompleks HypA-HypB te proteine CrdA i CrdB biofizičkim i strukturnim metodama (termalna stabilnost, cirkularni dikroizam, određivanje konstante disocijacije bakrovog iona, rentgenska difrakcija, 3D NMR). Želimo odrediti funkciju metalošaperona u unutarstaničnoj regulaciji nikla (HypA-HypB) kao i mehanizam regulacije koncentracije bakra (CrdA, CrdB).Istraživati ćemo komplekse metala (bakra, nikla, željeza i drugih esencijalnih metala) s ciljem da odredimo preferirano koordinacijsko okruženje metala s aminokiselinama i derivatima aminokiselina (N-alkiliranih, amida, peptida, peptida bogatih metioninom i drugih) te dobijemo informaciju o specifičnosti aminokiselinskog ili peptidnog pokrajnjeg lanca prema različitim metalnim ionima. Komplekse ćemo sintetizirati te ih karakterizirati termičkim i spektroskopskim metodama i rentgenskom strukturnom analizom. Konstruirat ćemo konformacije bakrovih kompleksa s aminokiselinama te optimizirati njihovu geometriju pomoću kvantno-kemijskih proračuna da bismo istražili njihove moguće ravnotežne geometrije.]]></summary_hr><summary_en><![CDATA[Within this project we will structurally characterize several proteins from Helicobacter pylori (and reveal their functions) and small molecule model complexes of essential metal ions with biologically relevant ligands (and find their properties). The priority will be the essential metals involved in H. pylori metalloproteins.The World Health Organization has declared the H. pylori a Class 1 carcinogen and it is an important target for research due to its pathological relevance. H. pylori requires several accessory proteins such as HypA and HypB for the proper construction of the [Ni,Fe] hydrogenase and urease. The resistance determinants CrdA and CrdB are required for keeping the concentration of free copper ions in the cytoplasm below toxic levels. We plan to clone, express, purify and characterize the complex HypA-HypB and proteins CrdA and  CrdB by biophysical and structural methods (thermal stability assay, circular dichroism, determination of copper ion dissociation constant, X-ray diffraction, 3D NMR). We hope to determine how the metallochaperones exert their functions in intracellular nickel delivery (HypA-HypB) and the mechanism of copper level regulation (CrdA, CrdB).The aim of the study of the model complexes (with copper, nickel, iron, zinc and other essential metal ions) is to determine how these metals template their coordination environment by amino acids and their derivatives (N-alkylated, amides, peptides, methionine-rich peptides and others) and to obtain information on the specificity of amino acid or short peptide side chains toward different metal ions. The complexes will be synthesized and structurally characterized by thermal and spectroscopic analysis and X-ray crystal structure diffraction experiments.The conformations of the copper complexes with amino acids will be constructed and the geometry optimized to study their possible equilibrium geometries by quantum chemical calculations.]]></summary_en></project><project>
<id>3015</id><title_hr><![CDATA[Sveoubuhvatna procjena ponašanja i sudbine farmaceutski aktivnih tvari u okolišu: makrolidni antibiotici i opioidni analgetici]]></title_hr><title_en><![CDATA[Comprehensive assessment of the environmental behaviour and fate of pharmaceutically active contaminants: macrolide antibiotics and opioid analgesics ]]></title_en><user_id>3673</user_id><user_firstLast_name>Senka Terzić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2014-09</proposal_call><code>IP-2014-09-7031</code><acronim><![CDATA[COMPASS]]></acronim><duration>01.09.2015 - 28.02.2019</duration><status>Završio</status><financ_value>114.008,89 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, Biologija, </scie_field_hr><scie_field_en>Chemistry, Biology, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>5324, 5719, 5179, 5188, 3923, 5158, 3674, 21293, </team_members_id><team_members_names><![CDATA[Ines Petrić, Marin Matošić, Ivona Krizman, Ivan Senta, Jovica Lončar, Iva Mikac, Marijan Ahel, Petra Kostanjevečki, ]]></team_members_names><keywords_hr><![CDATA[makrolidni antibiotici, opioidni analgetici, transformacijski proizvodi, transformacija, ozonizacija,  biološki efekti, otpadne vode ]]></keywords_hr><keywords_en><![CDATA[macrolide antimicrobials, opioid analgesics, transformation products, degradation, ozonization, biological effects, wastewaters]]></keywords_en><summary_hr><![CDATA[Većina studija farmaceutskih spojeva u okolišu usmjerena je na određivanje roditeljskih spojeva i uključuje samo jedan odjeljak okoliša. Takav pojednostavljeni pristup često podcjenjuje ekotoksikološku važnost neke farmaceutske skupine, bilo da se zanemaruje doprinos transformacijskih produkata (TP) ili tako da se previde neki kritični mehanizmi koji dovode do povećane opasnosti za okoliš i ljudsko zdravlje. Nasuprot tome, ovaj projekt ima za cilj ukazati na važnost sveobuhvatne evaluacije zagađivala voda na temelju istraživanja dviju skupina farmaceutskih spojeva, makrolidnih antibiotika (MA) i opioidnih analgetika (OA), pri čemu će biti uključeni njihovi glavni transformacijski produkti te će biti istražena uloga raspodjelnih procesa u procjeni izloženosti tim spojevima. Plan projekta predviđa razvoj visoko-specifičnih metoda za kvantitativno simultano određivanje ciljnih skupina spojeva i njihovih poznatih TP upotrebom tekućinske kromatografije povezane s tandemnom spektrometrijom masa(LC/MS/MS), dok će nepoznati TP biti identificirani upotrebom LC spregnute sa spektrometrijom masa visokog razlučivanja na temelju vremena leta (MS/TOF). Transformacijski procesi MA i OA bit će sustavno istraženi u kontroliranim laboratorijskim uvjetima, s posebnim naglaskom na biološku transformaciju i ozoniranje.  Biotransformacija će biti provedena s dobro karakteriziranim mješovitim mikrobnim kulturama izoliranim iz uzoraka s kronično zagađenih staništa. Istraživanje transformacijskih procesa obuhvatit će određivanje kinetike roditeljskih spojeva kao i identifikaciju transformacijskih produkata. Ekotoksikološki značaj istraživanih transformacijskih procesa bit će procijenjen kombinacijom postupaka baziranih na određivanju intenziteta nastajanja TP i promjene bioloških učinaka u nastalim transformacijskim smjesama. Projekt, na kraju, predviđa i verifikaciju relativne važnosti TP u realnim uvjetima, uključujući uređaje za pročišćavanje otpadnih voda i zagađene površinske vode.]]></summary_hr><summary_en><![CDATA[Most of the environmental studies of pharmaceuticals are focused mainly on the determination of parent compounds and encompass only one environmental compartment. Such simplified approach often underestimates the ecotoxicological relevance of a contaminant class, either by neglecting the contribution of its transformation products or by overlooking some critical mechanisms that may pose a threat to the environmental safety and human health. As opposed to that, this project aims at demonstrating the importance of the comprehensive assessment of aquatic contaminants, based on the study of two important groups of pharmaceuticals, macrolide antibiotics (MAs) and opioid analgesics (OAs), by including their main transformation products (TPs) and addressing the issue of physico-chemical partitioning in the exposure assessment. The project work plan envisages development of class-specific methods for the concurrent quantitative analysis of the target contaminants and their known TPs using liquid chromatography- tandem mass spectrometry (LC/MS/MS), while identification of unknown TPs will be performed using LC coupled to high-resolution mass spectrometry employing time-of-flight (TOF) mass analyzer. The transformation processes of selected contaminant classes will be systematically studied in laboratory-controlled conditions with a special emphasis on biotransformation and ozonation. The biotransformation experiments will be performed using well-characterised mixed microbial communities isolated from contaminated natural habitats. The transformation studies will encompass the determination of dissipation kinetics of the parent compounds as well as identification of TPs. Ecotoxicological importance of the transformation processes will be evaluated using a combination of exposure-driven and effect-driven approaches. Finally, the project envisages verification of the relative importance of TPs in real systems, including wastewater treatment plants and ambient surface waters.]]></summary_en></project><project>
<id>3016</id><title_hr><![CDATA[Fitohormoni u abiotskom stresu kupusnjača: mehanizam tolerancije i primjena]]></title_hr><title_en><![CDATA[Phytohormones in abiotic stress of  Brassica crops: mechanism of tolerance and application]]></title_en><user_id>791</user_id><user_firstLast_name>Branka Salopek Sondi</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2014-09</proposal_call><code>IP-2014-09-4359</code><acronim><![CDATA[PhytoBraCro]]></acronim><duration>01.09.2015 - 31.12.2019</duration><status>Završio</status><financ_value>121.166,37 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Biologija, </scie_field_hr><scie_field_en>Biology, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>12519, 998, 4217, 2689, 3827, 997, 3156, 3965, 2824, 5012, 3387, 3390, 17895, </team_members_id><team_members_names><![CDATA[Ondřej Novák, Hrvoje Lepeduš, NATAŠA BAUER, Dunja Šamec, Iva Pavlović, Selma Mlinarić, Jutta Ludwig-Müller, Ana Smolko, Jasenka Antunović, Snježana Mihaljević, Sandra Radić Brkanac, VALERIJA VUJČIĆ, Ida Linić, ]]></team_members_names><keywords_hr><![CDATA[kupusnjače, suša, solni stres, auksin, hormoni stresa]]></keywords_hr><keywords_en><![CDATA[Brassica crops, drought, salinity stress, auxin, stress hormons]]></keywords_en><summary_hr><![CDATA[Biljne vrste iz porodice Brassicaceae su široko rasprostranjene povrtne kulture. Abiotički stres poput suše i povećanog saliniteta tla su primarni uzroci gubitka u poljoprivrednoj proizvodnji. Fitohormoni su ključni za prilagodbu biljaka nepovoljnim uvjetima regulirajući procese kao što su fotosinteza, aktivnosti antioksidacijskih enzima, akumulacija sekundarnih metabolita, promjene u ekspresiji gena itd. Biljni hormoni auksini djeluju kao regulatori u većini odgovora biljaka na stres kroz složene interakcije s hormonima stresa: salicilnom (SA), abscizinskom (ABA), jasmonskom (JA) kiselinom i brazinosteroidima (BRA). Cilj ovog projekta je istražiti mehanizme odgovora odabranih biljaka iz porodice krstašica na stres uzrokovan sušom i povećanim salinitetom: kineski kupus (Brassica rapa), bijeli kupus (B. oleracea var. capitata) i raštika (B. oleracea var. acephala) kroz integrativni pristup koji podrazumjeva metode mjerenja fotosinteze, biokemijske metode dijagnostike stresa, metabolomiku (analize biljnih hormona i sekundarnih metabolita), molekularna funkcionalna te aplikativna istraživanja. Poseban naglasak će biti na ulozi fitohormona auksina i interakcijama s hormonima stresa (SA, ABA, JA, BRA) u odgovoru na sušu i povećani salinitet te potencijalnim mehanizmima tolerancije. Biljni hormoni biti će analizirani UHPLC-MS/MS metodom. Sekundarni metaboliti, polifenoli i glukozinolati biti će mjereni spektrofotometrijski i UHPLC-MS/MS metodama. Funkcionalna istraživanja će biti provedena na linijama uročnjaka (Arabidopsis thaliana) koje imaju mutacije u genima odgovornim za homeostazu auksina (gh3, ilr). Rezultati analiza bioaktivnih spojeva (hormona i sekundarnih metabolita) će biti korelirani s fiziološkim i biokemijskim podatcima (parametri fotosinteze, ROS, antioksidacijski enzimi, prolin, glutation, karbonili). Biljni hormoni stresa će biti ispitani kao potencijalni biostimulatori tolerancije na sušu i povećani salinitet aplikacijom na list i tretmanom korijena.]]></summary_hr><summary_en><![CDATA[Crops from the family of Brassicaceae are commercially widely spread vegetables. Abiotic stresses such as salinity and drought are the primary causes of crop loss worldwide. Phytohormones are crucial for the plant ability to adapt to abiotic stress by mediating a wide range of adaptive responses: photosynthesis modification, increased antioxidant activities, secondary metabolites accumulation, changes in gene expression. Phytohormone auxin regulates the majority of plant stress responses through interactions with stress hormones salicylic acid (SA), abscisic acid (ABA), jasmonic acid (JA), and brassinosteroids (BRA). The aim of this proposal is to investigate the abiotic stress responses of selected Brassica crops (Brassica rapa. ssp. pekinesis, Brassica oleracea var. capitata and Brassica oleracea var. acephala) to drought and salinity stress through integrative research approach comprising biophysical methods of photosynthesis measurements, biochemical methods of stress diagnostics, metabolomics (plant hormones and secondary metabolites) and molecular functional research. Particular focus will be placed to the role of auxin and its interactions with stress hormones (SA, ABA, JA and BRA) in stress responses and potential mechanisms of tolerance. Phytohormones auxin, SA, JA, ABA and BRA will be analyzed by UHPLC-MS/MS. Secondary metabolites, polyphenols and glucosinolates will be measured by spectrophotometry and UHPLC-MS/MS. In order to shed light on auxin homeostasis in abiotic stress, functional research will be performed by using Arabidopsis thaliana lines for genes of auxin reversible conjugation (GH3 and ILR). Results of hormonal analyses will be correlated with basic physiological and biochemical parameters (photosynthesis parameters, ROS level, antioxidant enzymes, proline, glutathione, protein carbonyl level). Finally, stress plant hormones will be investigate as potential biostimulator of abiotic stress tolerance by foliar spray and root treatment.]]></summary_en></project><project>
<id>3019</id><title_hr><![CDATA[Molekularni aspekti oksidativnih procesa u stanicama]]></title_hr><title_en><![CDATA[Molecular Aspects of Oxidative Processes in Cells]]></title_en><user_id>440</user_id><user_firstLast_name>Mario Vazdar</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2014-09</proposal_call><code>UIP-2014-09-6090</code><acronim><![CDATA[MolOxStress]]></acronim><duration>01.09.2015 - 31.12.2018</duration><status>Završio</status><financ_value>74.258,41 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, Fizika, Biologija, </scie_field_hr><scie_field_en>Chemistry, Physics, Biology, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>243, 373, 5002, 21289, 3618, </team_members_id><team_members_names><![CDATA[Davor Margetić, Katarina Vazdar, Danijela Vojta, Sanja Škulj, Zlatko Brkljača, ]]></team_members_names><keywords_hr><![CDATA[oksidativni stres, reaktivni aldehidi, membranski proteini, organska sinteza, molekulska dinamika, kvantnokemijski računi]]></keywords_hr><keywords_en><![CDATA[oxidative stress, reactive aldehydes, membrane proteins, organic synthesis, molecular dynamics, quantum chemical calculations]]></keywords_en><summary_hr><![CDATA[Cilj predloženog projekta je otkrivanje molekulskih detalja procesa vezanih za prijenos protona i oksidativni stres u mitohindrijima, organelima lociranim u stanicama koji služe za pretvorbu kisika i vanjskih izvora energije u adenozin trifosfat (ATP), u procesu oksidativne fosforilacije. Tijekom ovog procesa, osjetljiva energetska ravnoteža se održava pumpanjem protona izvan unutarnje mitohindrijske membrane uz pomoć lanca elektron-transport proteina te njihovog vraćanja unutra u procesu sinteze ATP-a pomoću ATP sintaze. Ova ravnoteža nije uvijek optimalna i posebna klasa proteina smještenih unutar unutrašnje mitohondrijske membrane, tzv. razvezujući proteini (&#39;&#39;uncoupling proteins&#39;&#39;), služe za kontrolu prijenosa protona kroz membranu.Posebna pažnja posvetit će se studiju reaktivnosti različitih reaktivnih aldehida koji se stvaraju tijekom oksidativnog stresa unutar fosfolipidnog dvosloja, prema razvezujućim proteinima. Ove štetne reakcije povećavaju aktivnost razvezujućih proteina koji dovodi i do povećanog protoka protona kroz unutrašnju mitohondrijsku membranu koja time mijenja energetsku ravnotežu unutar stanice što dovodi do raznih opasnih bolesti, poput raka, dijabetesa tipa 2 i pretilosti.Projekt će koristiti najnovije računske pristupe uz kombinaciju kvantnokemijskih računa i simulacija molekulske dinamike. Nadalje, teorijski proračuni će se nadopuniti modelnim eksperimentima gdje će se ispitati sintetizirani reaktivni aldehidi sa svrhom daljnjeg razumijevanja reaktvnosti, kao i dodatne provjere računskih rezultata.Ovo istraživanje će doprinijeti očuvanju zdravlja pružajući zajednici bolje razumijevanje osnovnih principa i mehanizama pomoću kojih opasni aldehidi reagiraju s razvezujućim proteinima. Predložit će se nove ideje s ciljem boljeg razumijevanja funkcije razvezujućih proteina, razvijanja lijekova za unaprijeđenje zdravlja te umanjivanju efekata oksidativnih procesa.]]></summary_hr><summary_en><![CDATA[The proposed project aims to unravel the molecular details of the processes connected with proton transfer and oxidative stress in mitochondria, organelles located in cells which convert oxygen and external energy supply into adenosine triphosphate (ATP) in the process of oxidative phosphorylation. During this process, a delicate energy balance is maintained between pumping of protons outside the inner mitochondrial membrane by the electron-transport chain proteins and transferring them back inside in the process of ATP synthesis by the ATP synthase. This balance is not always optimal and a special class of membrane proteins located inside inner mitochondrial membranes, called uncoupling proteins, serves as a control of the proton transfer rate through the membrane. Particular attention will be paid to the study of the reactivity of various reactive aldehydes generated during oxidative stress within phospholipid bilayers, towards uncoupling proteins. These deleterious reactions enhance the activity of uncoupling proteins resulting in the increased proton leak through inner mitochondrial membrane which in turn modifies energy balance inside the cell leading to various harmful diseases, such as cancer, type 2 diabetes and obesity. The project application uses the &#39;&#39;state of the art&#39;&#39; computational approach by combining quantum chemical calculations and molecular dynamics simulations. Also, the theoretical work is expanded with the experimental work where model compounds will be synthesized and used in model reaction systems to further understand and cross-check the simulation results. The research will endorse health by providing the community better understanding of the underlying principles and mechanisms by which deleterious aldehydes react with uncoupling proteins. The novel ideas will be proposed in order to better understand the function of uncoupling proteins, to develop drugs for improving health and to minimize effects due to oxidation processes.]]></summary_en></project><project>
<id>3021</id><title_hr><![CDATA[SenseHive: Dinamički modeli za postepenu izgradnju leksičko-semantičkih resursa potpomognuti radom mnoštva]]></title_hr><title_en><![CDATA[SenseHive: Dynamic Crowdsourcing Models for Incremental Construction of Lexico-Semantic Resources]]></title_en><user_id>6211</user_id><user_firstLast_name>Jan Šnajder</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2014-09</proposal_call><code>UIP-2014-09-7312</code><acronim><![CDATA[SenseHive]]></acronim><duration>01.10.2015 - 30.11.2018</duration><status>Završio</status><financ_value>94.233,19 eur</financ_value><scie_area_hr>Tehničke znanosti, Humanističke znanosti, </scie_area_hr><scie_area_en>Technological sciences, Humanities, </scie_area_en><scie_field_hr>Računarstvo, </scie_field_hr><scie_field_en>Computer sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id>6330, 6463, 6670, 1533, 7143, 7187, 7390, 7141, 13422, 18931, 22839, </team_members_id><team_members_names><![CDATA[Sebastian Pado, Darja Fišer, Tomislav Stojanov, Željko Agić, Nikola Ljubešić, Bojana Dalbelo Bašić, Mladen Karan, Goran Glavaš, Luka Skukan, Domagoj Alagić, Abbas  Akkasi, ]]></team_members_names><keywords_hr><![CDATA[Natural language processing, language technologies, lexical semantics, semantic resources, word sense disambiguation, Croatian language]]></keywords_hr><keywords_en><![CDATA[Obrada prirodnog jezika, jezične tehnologije, leksička semantika, semantički resursi, razrješavanje višeznačnosti, hrvatski jezik]]></keywords_en><summary_hr><![CDATA[Leksičko-semantički resursi igraju bitnu ulogu u obradi prirodnoga jezika i srodnih primjena poput pretraživanja informacija. Nažalost, njihova je  izgradnja izuzetno skupa te je rijetko vođena praktičnim potrebama, što kod jezika sa slabije razvijenim resursima predstavlja naročit problem. Moguće rješenje jest izgradnja leksičko-semantičkih resursa potpomognuta radom mnoštva (engl. crowdsourcing). Premda se rad mnoštva pokazao izvedivim i znatno povoljnijim pristupom, još uvijek ne postoji cjelovita metodologija koja bi omogućila postepenu izgradnju vrlo velikih leksičko-semantičkih resursa. Cilj ovoga projekta jest upotpuniti ovu prazninu i istražiti računalne modele i metode za postepenu i učinkovitu izgradnju leksičko-semantičkih resursa potpomognutu radom mnoštva. Istraživanje će objediniti modele za dinamičan rad mnoštva, modele semantike temeljene na korpusu (distribucijske modele i tematske modele) te aktivno strojno učenje, te polučiti cjelovit i jezično neovisan radni okvir, tzv. SenseHive. SenseHive objedinjuje prilagodiv prikaz značenja i leksičko-semantičkih veza riječi temeljen na grafovima (SenseGraph) i postupke za njegovu postepenu izgradnju. Značenja riječi dinamički se razdjeljuju i stapaju na temelju analize ljudskih ocjena dobivenih nad podatcima ekstrahiranima iz korpusa. U prvoj fazi projekta izgradit ćemo prototip i upotrijebiti ga za ciljane eksperimente na podatcima na hrvatskom, slovenskom i engleskom jeziku s ciljem odgovaranja na relevantna istraživačka pitanja. Kao dokaz koncepta, u drugoj ćemo fazi primijeniti SenseHive za izgradnju leksičko-semantičkog resursa za hrvatski jezik umjerene veličine, proširivanjem i obogaćivanjem postojećih leksičko-semantičkih resursa. Predloženo će istraživanje unaprijediti stanje znanosti u području računalne semantike i poluatomatske izgradnje jezičnih resursa te rezultirati konkretnim leksičko-semantičkim resursom za hrvatski jezik od velike praktične vrijednosti.]]></summary_hr><summary_en><![CDATA[Lexico-semantic resources play an essential role in natural language processing and related applications such as information retrieval. Unfortunately, their construction is extremely costly and rarely guided by practical considerations, posing a problem especially for less-resourced languages. One possible solution is to rely on crowdsourcing of lexico-semantic resources. Although crowdsourcing has proven to be a viable option for reducing the overall costs, there still does not exists a comprehensive crowdsourcing methodology for incremental construction of large-scale lexico-semantic resources. This projects aims to fill this gap by investigating the computational models and methods for incremental and cost-efficient crowdsourcing of lexico-semantic resources. The research will combine dynamic crowdsourcing, corpus-based models of semantics (distributional semantics and topic models), and active machine learning methods into a comprehensible and language-independent crowdsourcing framework, the SenseHive. The SenseHive consists of a flexible, graph-based representation of senses and lexico-semantic relations (SenseGraph), coupled with an incremental construction methodology. In SenseGraph, senses are dynamically split up and merged based on the analysis of human judgments on corpus-extracted data. In the first phase, we will implement a prototype of the SenseHive framework and use it for focused evaluation experiments on Croatian, Slovene, and English data to answer the relevant research questions. As a proof of concept, in the second phase we will use SenseHive to construct a medium-sized lexico-semantic resource for Croatian by enlarging and enriching existing lexico-semantic resources. The proposed research will advance the state of the art in computational lexical semantics and semi-automated construction of linguistic resources, and yield a lexico-semantic resource for Croatian of great practical value.]]></summary_en></project><project>
<id>3023</id><title_hr><![CDATA[Struktura i dinamika egzotičnih femto-sustava]]></title_hr><title_en><![CDATA[Structure and Dynamics of Exotic Femtosystems]]></title_en><user_id>11296</user_id><user_firstLast_name>Nils Paar</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2014-09</proposal_call><code>IP-2014-09-9159</code><acronim><![CDATA[STRUDEF]]></acronim><duration>01.06.2015 - 31.05.2019</duration><status>Završio</status><financ_value>132.652,60 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, </scie_field_hr><scie_field_en>Physics, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>780, 12571, 18998, 25236, </team_members_id><team_members_names><![CDATA[Tamara Nikšić, Deni Vale, Nato Popara, Tomohiro Oishi, ]]></team_members_names><keywords_hr><![CDATA[egzotične jezgre, energijski  funkcional gustoće, kolektivno gibanje, fisija, beta raspad, gibanje velikih amplituda]]></keywords_hr><keywords_en><![CDATA[exotic nuclei, energy density functional, nuclear collective motion, fission, beta decay, large amplitude motion]]></keywords_en><summary_hr><![CDATA[Osnovni cilj ovog projekta je razviti i primijeniti novi teorijski pristup, zasnovan na relativističkom nuklearnom energijskom funkcionalu gustoće (RNEDF) koji  omogućuje mikroskopski opis strukture i dinamike kvantnih sustava na femtometarskoj skali, te omogućuje precizan opis egzotičnih femto-sustava daleko od doline stabilnosti koji još nisu dostupni u eksperimentu. Radi se o jezgrama čija struktura i dinamika pokazuju egzotična svojstva, npr. veličinu i oblik vrlo različite od najbližih stabilnih jezgara, ili egzotične modove kolektivnog pubuđenja i raspada. Istraživački projekt uključuje razvoj teorijskog formalizma i pripadajućih modela na temelju RNEDF-a radi ostvarenja sljedećih ciljeva: (i) razviti pouzdanije funkcionale s unaprijeđenom efektivnom masom blizu Fermi površine i poboljšanim spin-orbit međudjelovanjem u izovektorskom kanalu, (ii) omogućiti kvantitativni opis statističke neodređenosti i korelacija između nuklearnih svojstava pomoću analize kovarijanci, (iii) opisati pobuđenja malih amplituda pomoću metode konačnih amplituda i vezanjima sa složenim konfiguracijama, (iv) nadograditi metodu generatorskih koordinata za gibanje velikih amplituda, (v) istražiti fenomene koegzistencije oblika i prijelaza između različitih oblika jezgara, (vi) proučiti strukturu i stabilnost superteških jezgara i proces fisije (vii) istražiti astrofizički značajne nuklearne procese koji uključuju slabu interakciju. Predviđen je razvoj naprednih teorijskih metoda za rješavanje izazova koje predstavljaju sadašnji i budući ubrzivači snopova nestabilnih iona, odnosno razumijevanje rijetkih jezgara daleko od stabilnosti koje igraju značajnu ulogu u sintezi svih stabilnih kemijskih elemenata koji danas postoje na Zemlji. Ključni pristup za ostvarenje znanstvenih ciljeva i povećanje prediktivne snage za opis egzotičnih femto-sustava je razvoj i primjena učinkovitih računalnih alata i metoda naprednog računarstva i njihova primjena na distribuiranim računalnim sustavima.]]></summary_hr><summary_en><![CDATA[The goal of this project is to develop and apply a novel theoretical framework, based on Relativistic Nuclear Energy Density Functional (RNEDF) that enables microscopic modeling of the structure and dynamics of quantum systems at the femtometer scale, and provides accurate predictions for exotic femtosystems far from stability that are not yet accessible in experiment. These nuclei have exotic or unusual structural and dynamical properties such as, for instance, sizes and shapes very different from their nearest stable nuclei, or exotic modes of collective excitation and decay by particle emission. The project research includes development of the framework based on the RNEDF with specific aims to (i) develop a more reliable functional with enhanced effective mass near the Fermi surface and improved spin-orbit interaction in the isovector channel, (ii) provide quantitative description of statistical uncertainties and correlations of nuclear properties using covariance analysis, (iii) to describe low-amplitude motion using finite amplitude method and couplings with complex configurations, (iv) upgrade the generator-coordinate method framework for large amplitude motion , (v) explore phenomena of shape coexistence and shape transitions, (vi) study the structure and stability of superheavy nuclei and fission process, (vii) explore astrophysically relevant nuclear processes including weak interaction. This will require the development of advanced theoretical methods to resolve the challenge posed by the current and future large-scale radioactive ion beam facilities, namely the understanding of rare nuclei far from stability that are precursors in the synthesis of all stable nuclear species on Earth. A key ingredient in achieving the theoretical goal of increased predictive power for exotic femtosystems is development and application of efficient computational tools and methods of scientific computing using distributed computer systems.]]></summary_en></project><project>
<id>3024</id><title_hr><![CDATA[Procesna i poslovna inteligencija za poslovnu izvrsnost ]]></title_hr><title_en><![CDATA[Process and Business Intelligence for Business Performance ]]></title_en><user_id>1246</user_id><user_firstLast_name>Vesna Bosilj Vukšić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2014-09</proposal_call><code>IP-2014-09-3729</code><acronim><![CDATA[PROSPER]]></acronim><duration>01.09.2015 - 31.08.2019</duration><status>Završio</status><financ_value>29.995,35 eur</financ_value><scie_area_hr>Društvene znanosti, Tehničke znanosti, </scie_area_hr><scie_area_en>Social sciences, Technological sciences, </scie_area_en><scie_field_hr>Informacijske znanosti, Računarstvo, Ekonomija, </scie_field_hr><scie_field_en>Information sciences, Computer sciences, Economy, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Ekonomski fakultet u Zagrebu]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Economics and Business]]></institution_en><team_members_id>1372, 3650, 1313, 3417, 3436, 3630, 1272, 3588, 3695, 3766, 3106, 4411, 2520, 22659, </team_members_id><team_members_names><![CDATA[Mirjana Pejić Bach, Božidar Jaković, Jovana Zoroja, Ljubica Milanović Glavan, Mirta Baranović, Ljiljana Brkić, Katarina Tomičić-Pupek, Jurij Jaklič, Mojca Indihar Štemberger, Aleš Popovič, Amer Celjo, Jan Mendling, Dalia Suša, Ana-Marija Stjepić, ]]></team_members_names><keywords_hr><![CDATA[procesna inteligencija, poslovna inteligencija, upravljanje poslovnim procesima, mjerenje i upravljanje performansama, rudarenje podataka, softver]]></keywords_hr><keywords_en><![CDATA[process intelligence, business intelligence, business process management, performance measurement and management, data mining, software]]></keywords_en><summary_hr><![CDATA[Svrha projekta PROSPER je istražiti primjenu procesne (PI) i poslovne inteligencije (BI) u poduzećima i njihov utjecaj na uspješnost poslovanja, s posebnim fokusom na korištenje modernih tehnologija (kao što su sustavi za upravljanje poslovnim procesima, rudarenje podataka, simulacijski softver) pri implementaciji ovih koncepata. Primijenit će se odgovarajući istraživački pristup. Koristiti će se statističke metode (kao što su modeli strukturnih jednadžbi - SEM) i metode kvalitativnog istraživanja (na primjer kvalitativno istraživanje kulturalnih razlika primjene procesne i poslovne inteligencije u u Hrvatskoj, Sloveniji, Austriji i Bosni i Hercegovini). Projekt je multidisciplinaran i više-razinski, a njegovi su ciljevi hijerarhijski strukturirani.Na najvišoj razini (L1) istražit će se primjena i zrelost procesne i poslovne inteligencije u  zemljama iz kojih dolaze suradnici na projektu. Provest će se empirijsko istraživanje, dobiveni rezultati analizirati će se kvantitativnim metodama (regresijska i faktorska analiza). Na drugoj razini (L2) istražit će se kritični faktori uspješnosti primjene koncepata procesne i poslovne inteligencije. U tu svrhu će se koristiti kvalitativne (studije slučaja, polu-strukturirani intervjui)  i kvantitativne metode (modeli strukturnih jednadžbi).  Rezultati istraživanja koristiti će se za razvoj modela za mjerenje procesnih performansi. Na trećoj razini (L3) testirati će se primjenjivost rezultata istraživanja iz prethodnih razina (L1 i L2), a u tu svrhu će se provesti kvalitativno istraživanje u poduzećima. Kroz studije slučaja testirati će primjena procesne i poslovne inteligencije i njihov utjecaj na uspješnost poslovanja.  Razviti će se modeli iz područja poslovne inteligencije za neke specifične poslovne slučajeve i djelatnosti. Primjena ovih modela omogućiti će uspješnije poslovanje. ]]></summary_hr><summary_en><![CDATA[The aim of the PROSPER project is to examine the adoption of the process intelligence (PI) and business intelligence (BI) in organizations, as well as to foresee their impact on business performance using cutting-edge technologies (e.g. business process management systems, data mining, simulation software) and research approach (e.g. cross-cultural research, structural equation modelling) with the assistance of multi-country (Croatia, Slovenia, Austria, Bosnia and Herzegovina) and interdisciplinary team of university researchers. The project is multidisciplinary and multi-levelled due to the hierarchical structure of its objectives.At the highest level (L1), the adoption and maturity of PI and BI will be explored in organizations in Croatia, Slovenia, Bosnia and Herzegovina and Austria. A quantitative empirical research results will be analysed using regression and factor analysis. At the middle level (L2), the impact of critical factors (e.g. organizational culture and structure) on PI and BI adoption will be analyzed. L2 research results will be explored using qualitative (e.g. case study, semi-structured interviews) and quantitative methods (e.g. structural equation modelling), the goal being development of the process performance measurement model. At the third level (L3), the practical applicability of the L1 and L2 research results will be tested and evaluated using specific business cases in PI and BI adoption for business performance. Models will be developed for the usage of BI in some specific business cases and industries, with the goal of increasing business performance.]]></summary_en></project><project>
<id>3027</id><title_hr><![CDATA[Višekomponentne reakcije u sintezi peptidnih mimetika]]></title_hr><title_en><![CDATA[The assembly of peptidomimetics by multicomponent reactions]]></title_en><user_id>66</user_id><user_firstLast_name>IVANKA JERIĆ</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2014-09</proposal_call><code>IP-2014-09-3102</code><acronim><![CDATA[MIMICRy]]></acronim><duration>01.09.2015 - 31.08.2019</duration><status>Završio</status><financ_value>125.821,22 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, </scie_field_hr><scie_field_en>Chemistry, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>558, 715, 717, 12506, 12613, 12635, 373, 21264, 24292, 25282, </team_members_id><team_members_names><![CDATA[Matija Gredičak, Lidija Brkljačić, Josipa Suć, Kristina Vlahoviček-Kahlina, Lidija Varga-Defterdarović, Andreja  Jakas, Katarina Vazdar, Mladena Glavaš, Ivana Kovačić, Mateja Matišić, ]]></team_members_names><keywords_hr><![CDATA[peptidomimetici, višekomponentne reakcije, makrociklički spojevi, neprirodne aminokiseline, ugljikohidrati, endiinski spojevi]]></keywords_hr><keywords_en><![CDATA[peptidomimetics, multicomponent reactions, macrocycles, non-natural amino acids, carbohydrates, enediyne compounds]]></keywords_en><summary_hr><![CDATA[Probir biblioteka malih molekula je najčešće korišten pristup u otkriću novih lijekova u posljednih dvadeset godina. Međutim, glavni nedostatak biblioteka je mala raznovrsnost bioloških i kemijskih svojstva spojeva koje sadrže, tj. biblioteke pokrivaju vrlo mali «kemijski prostor». U posljednjih 15 godina, svega 15 % novih kemijskih spojeva zapravo pripadaju novim klasama spojeva. To predstavlja glavnu zapreku razvoju novih vodećih spojeva potrebnih za istraživanje novih bioloških meta. Cilj ovog projekta je proširiti kemijski prostor novim spojevima koji imaju slične karakteristike kao i prirodni spojevi, korištenjem višekomponentnih reakcija. To ćemo postići: (a) razvojem novih gradivnih jedinica temeljenih na neprirodnim aminokiselinama, ugljikohidratima i endiinskim spojevima, (b) provođenjem Passerinijeve i Ugijeve reakcije za dobivanje raznovrsnih linearnih i cikličkih produkata i (c) proučavanjem stereokemije višekomponentnih reakcija.  	Rezultati projekta i znanje o metodologiji, stereokemiji i svojstvima novih spojeva značajni su za istraživanja u više područja: medicinska kemija (nove strukture za obogaćivanje biblioteka spojeva), razvoj katalizatora (posebno makrociklički spojevi s endiinskom jedinicoma) i biomedicinska istraživanja (spojevi s ugljikohidratnim strukturnim elementom mogu se koristiti kao biološke probe). Projekt je usklađen s ciljevima Hrvatske zaklade za znanost: razvoj konkurentnog istraživačkog okruženja i stvaranje novih znanja za jačanje hrvatskog gospodarstva. Rezultati projekta će biti temelj za stvaranje bibliteka sa strukturno različitim malim molekulama i makrocikličkim spojevima, kao odgovor na potrebe farmaceutske industrije: identifikacija još nepoznatih bioloških ciljeva i razvoj novih vodećih spojeva. Stoga projekt doprinosi i jednom od ključnih ciljeva u Europskoj uniji: poboljšanju zdravlja građana EU-a za povećanje bogatstva i dobrobiti ljudi. ]]></summary_hr><summary_en><![CDATA[Screening of small-molecule libraries has been the most commonly used tool in drug discovery over the past two decades. However, currently used libraries lack diversity in terms of biological and chemical properties, i.e. “chemical space” covered is infinitely small. In the past 15 years, only 15 % of the emerging novel chemical entities have been novel classes of compounds. This limitation significantly hampers development of novel lead compounds needed to tackle new generations of biological targets. The project goal is to expand the chemical space of natural product-like compounds by using multicomponent reactions. This will be achieved by: (a) developing novel non-natural amino acid-, carbohydrate- and enediyne-based building blocks; (b) performing Passerini and Ugi multicomponent reactions to obtain structurally diverse linear and macrocyclic compounds and (c) studying the stereochemistry of multicomponent reactions. Project results, and the knowledge about methodologies, stereochemistry and properties of novel compounds, are highly relevant for the following fields: medicinal chemistry - novel structures to fill the libraries; catalyst development – particularly enediyne-based macrocycles; and biomedical studies – carbohydrate-based compounds can be used as biological probes. Project is aligned with the goals of the Croatian Science Foundation: development of competitive research environment, and creation of new knowledge for the strengthening the Croatian economy. Project results will be the base for the generation of libraries with structurally diverse peptide-like small molecules and macrocyclic compounds, as an answer to the pharmaceutical industry needs: identification of yet undisclosed biological targets and the development of novel lead compounds. Therefore, project contributes to one the key objectives in the European Union: improving the health of EU citizens for generation of wealth and public wellbeing. ]]></summary_en></project><project>
<id>3030</id><title_hr><![CDATA[Internet stvari - okvir interoperabilnosti]]></title_hr><title_en><![CDATA[Internet of Things – Interoperability Framework ]]></title_en><user_id>12678</user_id><user_firstLast_name>Neven Vrček</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2014-09</proposal_call><code>IP-2014-09-3877</code><acronim><![CDATA[IoTIF]]></acronim><duration>01.06.2015 - 31.05.2019</duration><status>Završio</status><financ_value>78.322,90 eur</financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Informacijske znanosti, </scie_field_hr><scie_field_en>Information sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet organizacije i informatike]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Organization and Informatics]]></institution_en><team_members_id>12786, 5699, 12796, 202, 12805, 12793, 13514, 13611, 13612, 2508, </team_members_id><team_members_names><![CDATA[Sandro Gerić, Renata Mekovec, Darko Andročec, Boris Tomaš, Igor Pihir, Tonimir Kišasondi, Mate Boban, Dragutin Kermek, Matija Novak, Igor Tomičić, ]]></team_members_names><keywords_hr><![CDATA[internet stvari, energetska učinkovitost, interoperabilnost, automatsko konfigurabilne arhitekture, pitanja sigurnosti i privatnost]]></keywords_hr><keywords_en><![CDATA[Internet of Things, energy efficiency, large scale interoperability, automated architecture reconfiguration, security and privacy issues]]></keywords_en><summary_hr><![CDATA[Internet stvari je „dinamična globalna mrežna infrastruktura koja ima mogućnost automatske konfiguracije i bazirana je na standardnim interoperabilnim komunikacijskim protokolima gdje fizičke i virtualne stvari posjeduju identitete, fizičke atribute i virtualne osobnosti, koriste inteligentna sučelja, te su integrirani u informacijsku mrežu“ (Vermesan, 2014). Općenito, Internet stvari (IoT) se opisuje kao globalna mreža međusobno povezanih entiteta poput ljudi, računala, knjiga, vozila koji mogu ostvariti otvorenu komunikaciju s bilo kojim drugim entitetom i mjestom na bilo koji način (Roman, Zhou i Lopez, 2013). IoT mreža je iznimno heterogena, te kako bi se iskoristili njezini potencijali potrebno je ostvariti visoku razinu interoperabilnosti između uređaja u IoT mreži. Istraživanja interoperabilnosti u IoT okruženju su još u početnim fazama. U okviru projekta usmjerit ćemo se na interoperabilnost na razini usluga, te upotrebom semantičkog jezika i AI algoritama pokušati riješiti probleme konfigurianja i interoperabilnosti u IoT okruženju. Ideja je predstaviti IoT uređaje kao usluge (servise) te ih opisati semantičkim jezikom (SA-WSDL). Pri tome će se razviti OWL ontologija za opis elemenata IoT okruženja. Uključeni IoT uređaji će biti opisani, njihove funkcije i operacije također, što će omogućiti razvijenom algoritmu umjetne inteligencije da kombinira i dinamički u IoT okruženje uključuje i povezuje one uređaje koji doprinose rješavanju zadanog problema. Uz to će se ostvariti integracija IoT uređaja sa cloud platformom, čiji kapaciteti se mogu iskoristiti kao podrška i dodatna funkcionalnost IoT okruženju.]]></summary_hr><summary_en><![CDATA[Internet of Things (IoT) is “a dynamic global network infrastructure with self configuring capabilities based on standard and interoperable communication protocols where physical and virtual things  have identities, physical attributes, and virtual personalities; use intelligent interfaces; and are seamlessly integrated into the information network”. It is highly-heterogeneous, so to unleash its full value we must to achieve interoperability among various things. Research on the interoperability of IoT is in the initial stage. We will focus on service-level interoperability and we will use lightweight semantic language and AI planning methods to resolve found problems of heterogeneous things abstracted in form of semantic web services. Our idea is to represent things as services and semantically annotate them by using lightweight semantic language such as SA-WSDL. OWL Ontology for describing the things and their most important operations will be developed. Things as services will be annotated using the developed ontology, together with their main operations and operations’ input and output. AI planning problem and domain will be formulated to enable composition of various things as services. Then an AI tool together with web interface will be developed to enable users to achieve more complex tasks composing various things and their capabilities. We will investigate how we can integrate our approach with existing cloud computing services, i.e. we will develop a framework for integration of clouds and Internet of Things. Cloud services can enrich things as service with storage, application and resource capabilities. Therefore, cloud services will be semantically annotated using similar approach as semantically annotated smart things. This will enable us to create compositions of different things as services and cloud services to support more complex interoperability scenarios by using common ontology and AI planning method. ]]></summary_en></project><project>
<id>3031</id><title_hr><![CDATA[Novi enološki postupci kao alternativa sumporovom dioksidu u proizvodnji visokokvalitetnih vina]]></title_hr><title_en><![CDATA[New enological tools for the reduction of sulfur dioxide and production of high-quality wine]]></title_en><user_id>6224</user_id><user_firstLast_name>Karin Kovačević Ganić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2014-09</proposal_call><code>IP-2014-09-3796</code><acronim><![CDATA[LOWSULF-HQWINE]]></acronim><duration>01.09.2015 - 31.08.2019</duration><status>Završio</status><financ_value>124.646,63 eur</financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Prehrambena tehnologija, </scie_field_hr><scie_field_en>Food technology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prehrambeno-biotehnološki fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Food Technology and Biotechnology]]></institution_en><team_members_id>13101, 13272, 13352, 222, 13282, 2653, 21313, </team_members_id><team_members_names><![CDATA[Ksenija Marković, Natka Ćurko, Tomislav Bosiljkov, Marina Đapić, Leo Gracin, Stela Križanović, Katarina Lukić, ]]></team_members_names><keywords_hr><![CDATA[Vino, SO2, antimikrobno djelovanje, kvaliteta vina, ultrazvuk visokog intenziteta (HPU), visoki hidrostatski tlak (HHP), hladna plazma (NTP)]]></keywords_hr><keywords_en><![CDATA[wine, SO2, antimicrobial activity, wine quality, high power ultrasound (HPU), high hydrostatic pressure (HHP) and non-thermal plasma (NTP)]]></keywords_en><summary_hr><![CDATA[Suvremeni zahtjevi za povećanjem sigurnosti i kvalitete vina utjecali su na preporuke o smanjenju, ali i na nove zakonske restrikcije u upotrebi sumporovog dioksida. Naime, zbog svojih antimikrobnih i antioksidacijskih karakteristika, sumporov dioksid jedan je od najučinkovitijih aditiva u proizvodnji vina. Međutim, uslijed potencijalnih pseudo-alergijskih reakcija koje kod osjetljivih pojedinaca dovode do zdravstvenih problema, korištenje sumporovog dioksida danas je pod razmatranjem. Stoga su i znanstvena istraživanja u posljednjem desetljeću intenzivno usmjerena na pronalaženje alternativa sličnih antiseptičkih i antioksidacijskih svojstava, kojima bi se zamijenila/smanjila upotreba sulfita u proizvodnji vina; što i danas predstavlja jedan od najznačajnijih enoloških izazova. U posljednje vrijeme, tehnologije kao ultrazvuk visokog intenziteta (HPU), visoki hidrostatski tlak (HHP) te hladna plazma (NTP) otvorile su nove mogućnosti u kontroli mikrobiološke kvalitete hrane te su stoga našle sve veću primjenu u prehrambenoj industriji. Međutim, primjena ovih novih, netermalnih postupaka u proizvodnji vina i njihov utjecaj na mikrobiološku stabilnost vina do sada nije istražen. Cilj projekta je istražiti mogućnosti primjene HPU, HHP i NTP sa svrhom smanjenja upotrebe sumporovog dioksida u proizvodnji visokokvalitetnih crnih, bijelih i desertnih vina. Ispitat će se utjecaj ovih netermalnih postupaka na cjelokupnu kvalitetu vina, u prvom redu na sastav polifenola, arome te senzorske karakteristike vina. Također, istražit će se mogućnosti ovih postupaka u kontroli mikrobiološke stabilnost vina. Nadalje, ispitat će se i sinergijski učinak navedenih postupaka te dodatka antioksidansa (niži udio sumporovog dioksida i glutation) tijekom dozrijevanja vina u bocama. Rezultati ovog projekta pokazat će kako primjenom novih netermalnih tehnologija samostalno ili u kombinaciji s antioksidansima proizvesti vina poboljšane kvalitete s nižim udjelom sumporovog dioksida.]]></summary_hr><summary_en><![CDATA[Modern increasing requirements for wine safety and quality led to very restrictive legislation regarding sulfur dioxide addition recommending limitations or even complete suppressing. In fact, sulfur dioxide is one of the most efficient additives used in winemaking due to its antimicrobial and antioxidant properties. However, as a result of potential pseudo-allergenic health problems in sensitive individuals use of sulfur dioxide has recently come under the review. Hence, in recent decades, alternatives to reducing/replacing sulfites in winemaking have been extensively studied. However, finding promising substitutes with similar antiseptic and antioxidant characteristics still remains major challenge. Recently, emerging technologies such as high power ultrasound (HPU), high hydrostatic pressure (HHP) and non-thermal plasma (NTP) have entered the field of food science and technology offering, as novel tools, new opportunities for managing food microbiology. Their opportunities in wine microbiology have not been examined. The aim of this project is to study the potential usage of HPU, HHP and NTP in production of high quality red, white and dessert wine as sulfur dioxide reducing strategies, and furthermore to optimize their application. Impact on overall wine quality, particularly chemical and sensory characteristic will be studied. Possibilities of these new technologies in controlling microbiological stability of wine will be investigated. In addition, synergistic practices of these physical technologies with antioxidants (lower content of sulfur dioxide and glutathione) during long period of aging in the bottles will be studied. The results of this project are expected to provide information how application of new physical technologies on its own or in combination with antioxidant addition can lead to wines with lower levels of sulfur dioxide and improved quality.]]></summary_en></project><project>
<id>3041</id><title_hr><![CDATA[Pogrebni običaji starijeg željeznog doba u južnoj Panoniji - raskrižja identiteta]]></title_hr><title_en><![CDATA[Burial Customs of the Early Iron Age in Southern Pannonia - Crossroads of Identity]]></title_en><user_id>3432</user_id><user_firstLast_name>Hrvoje Potrebica</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2014-09</proposal_call><code>IP-2014-09-1234</code><acronim><![CDATA[BC-CrossId]]></acronim><duration>01.06.2015 - 31.05.2019</duration><status>Završio</status><financ_value>79.633,69 eur</financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Arheologija, </scie_field_hr><scie_field_en>Archeology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Filozofski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Humanities and Social Sciences]]></institution_en><team_members_id>12745, 12736, 12812, 11263, 12982, 12742, 25275, </team_members_id><team_members_names><![CDATA[Petra Stipančić, Janja Mavrović Mokos, Borut Križ, Branko Mušič, Renata Šoštarić, Andrijana Pravidur, Julia Katarina Fileš Kramberger, ]]></team_members_names><keywords_hr><![CDATA[starije željezno doba, pogrebni običaji, identitet, halštatska kultura, pogrebne gomile, elite, kneževski grobovi, Alpe, Panonija]]></keywords_hr><keywords_en><![CDATA[Early Iron Age, burial customs, identity, Hallstatt Culture, burial mounds, elites, princely burials, Alps, Pannonia]]></keywords_en><summary_hr><![CDATA[Cilj ovog projekta jest utvrditi način na koji željeznodobne zajednice izražavaju svoj identitet kroz pogrebni ritual. Pri istraživanju bi se u najvećoj mjeri primjenjivao kontekstualni pristup: materijalna kultura se neće promatrati isključivo kao tipološka kategorija nego će biti povezana s kontekstom pogrebnog inventara i rituala. Namjera nam je pokazati da je mobilnost bila daleko intenzivnija i veća na razini pojedinaca i manjih skupina nego na razini čitavih zajednica. Smatramo da pogrebni ritual i materijalna kultura vezana uz takve cjeline jasno ukazuje da se pitanju identiteta željeznodobnih kulturnih skupina treba pristupiti analitički na razini pojedinih zajednica. Provest ćemo poredbenu analizu istovremenih i koncepcijski sličnih grobnih inventara koje pronalazimo u različitim kulturnim skupinama u različitim kontekstima pogrebnog rituala. Na taj način pokušali bismo na razini pojedinih zajednica razložiti i definirati pojedine aspekte materijalne kulture i ritualnog konteksta koji tvore identitet pokojnika. Koristeći te rezultate mogli bismo utvrditi koje od utvrđenih elemenata koristimo pri definiranju identiteta na razini pojedine zajednice, kulturne skupine ili šire, i koliko je takav pristup opravdan i univerzalno primjenjiv. Korelacijom podataka o materijalnoj kulturi, prostornoj organizaciji i ritualnom kontekstu, utvrdit ćemo pojedine elemente koji definiraju identitet pokojnika na temeljnoj razini (spol, dob, status, vrijeme ukopa) kao i na razini zajednice (status i uloga). Usporedbom podataka za pojedine zajednice provjerit ćemo postoji li specifičan skup elemenata kojima se pojedine zajednice izdvajaju unutar kulturnih skupina, odnosno postoje li poveznice između zajednica koje definiraju identitet pojedinih kulturnih skupina i izdvajaju ih jedne od drugih. Rezultat će biti set markera koji bi unutar definiranih razdoblja željeznog doba određivao identitet pokojnika u odnosu na njegovu osnovnu zajednicu i/ili kulturnu skupinu.]]></summary_hr><summary_en><![CDATA[The goal of this project is to identify the way in which the Iron Age communities expressed their identity through the burial ritual. The proposed project will research the burial ritual as a reflection of identity of Iron Age communities, mostly by applying the contextual approach. The material culture will not be viewed only as a typological category, but rather it will be linked to the context of the grave inventory and the burial ritual. The burial ritual and material culture associated with graves clearly suggest that the issue of identity of the Iron Age cultural groups should be analysed at the level of individual communities. We will carry out a comparative analysis of contemporary and conceptually similar grave inventories discovered in different burial contexts and belonging to different cultural groups. By doing so, we will attempt to examine and define some aspects of the material culture and ritual context which make up the identity of the deceased, at the level of individual communities. Such results would enable us to establish which of the identified elements are used when defining the identity at the level of a community, cultural group or a wider unit, and whether such an approach is justifiable and universally applicable. A co-relation of data concerning the material culture, spatial organization and ritual context will be used to identify elements which determine the deceased’s identity at the basic level (sex, age, time of burial) and at the level of the community (status and role). By comparing data on different communities we will check if there is a specific group of elements that sets apart some communities within a cultural group, and whether there are links between communities which define the identity of certain cultural groups. The result will consist of a set of identification markers, which will determine the identity of the deceased with respect to their basic community and/or cultural group (within the timeframe of the Iron Age).]]></summary_en></project><project>
<id>3042</id><title_hr><![CDATA[Integracijski procesi većine i manjine u etnički mješovitim zajednicama: uloga međuetničkog kontakta, percipirane prijetnje i socijalnih normi]]></title_hr><title_en><![CDATA[Integration processes of majority and minority in ethnically mixed communities: The role of interethnic contact, perceived threat and social norms]]></title_en><user_id>11126</user_id><user_firstLast_name>Dinka Čorkalo Biruški</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2014-09</proposal_call><code>IP-2014-09-4499</code><acronim><![CDATA[IntegraNorm]]></acronim><duration>01.10.2015 - 29.02.2020</duration><status>Završio</status><financ_value>72.266,13 eur</financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Psihologija, </scie_field_hr><scie_field_en>Psychology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Filozofski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Humanities and Social Sciences]]></institution_en><team_members_id>11293, 11284, 20494, 20454, 20453, 24512, 26898, </team_members_id><team_members_names><![CDATA[Tea Pavin Ivanec, Jasmina Tomašić  Humer, Blaž Rebernjak, Margareta Jelić, Lana Pehar Pehar, Ena Uzelac, Iva Kapović, ]]></team_members_names><keywords_hr><![CDATA[socijalna integracija, odnosi većine i manjine, međuetnički kontakt, međugrupna prijetnja, socijalne norme, obrazovanje manjina]]></keywords_hr><keywords_en><![CDATA[social integration, majority and minority relations, interethnic contact, intergroup threat, social norms, minority education]]></keywords_en><summary_hr><![CDATA[Cilj projekta je ispitati dugoročne efekte međuetničkog kontakta na ideološke i međuetničke stavove i ponašanja djece, adolescenata i njihovih roditelja, pripadnika većine i manjina, u četiri višeetničke zajednice u Republici Hrvatskoj. Jedinstven kontekst ispitivanja su manjinske i većinske škole, u kojima se nastava odvija na manjinskom jeziku (srpski, talijanski, mađarski i češki) ili pak na jeziku većine (hrvatski), a uključivanje čak četiri manjinske zajednice čini projektni prijedlog sasvim originalnim. Kao mogući mehanizmi djelovanja kontakta na međugrupne stavove i ponašanja istražit će se međugrupna prijetnja (realna i simbolička, te međugrupna tjeskoba), te, posebno, socijalne norme. Istraživanje predstavlja iskorak, jer zahvaća nekoliko aspekata međugrupne prijetnje kao posredujućeg mehanizma u odnosu međugrupnog kontakta i međugrupnih stavova i ponašanja, kao i temeljne izvore utjecaja u djece i adolescenata - roditeljske, vršnjačke i školske norme. U istraživanju će sudjelovati učenici osnovne i srednje škole, pripadnici četiri nacionalne manjine u Republici Hrvatskoj (Srbi, Talijani, Česi, Mađari) i većine, u dobi od 12 do 17 godina (N=1200) i njihovi roditelji (N=2400). Istraživanje kombinira kvalitativni i kvantitativni pristup. Kvalitativnom metodologijom (fokusne grupe, intervjui, ali i metoda opažanja) ispitat će se eksplicitne i implicitne školske norme o međuetničkom kontaktu, te potom formulirati instrument za njihovo mjerenje. Kvantitativni dio ispitivanja provest će se u dva vala, s razmakom od godine dana, te će se pratiti efekti međuetničkog kontakta na ideološke (stav prema multikulturnosti i asimilaciji), i na međugrupne stavove i ponašanja. Pri tome će se provjeriti pod kojim uvjetima, kako i koje socijalne norme utječu na vezu kontakta i međugrupnih stavova i ponašanja, te kakva je pri tome uloga međugrupne prijetnje. Rezultati projekta mogu biti relevantni za osmišljavanje integracijske uloge škole u višeetničkim zajednicama.]]></summary_hr><summary_en><![CDATA[The study aims to examine long-term effects of interethnic contact on ideological and interethnic attitudes and behaviors of majority and minority children, adolescents and their parents in four multiethnic communities in Croatia. A unique context of the study is provided by setting the research in the context of minority and majority schooling, where teaching is provided in either majority (Croatian) or minority languages (Italian, Serbian, Czech and Hungarian). Inclusion of multiple minority communities simultaneously makes this project sample rather unique. Intergroup threat (symbolic, realistic and intergroup anxiety) and especially social norms are hypothesized as being key mechanisms of influence of the interethnic contact. A novelty of the research is in encompassing multiple aspects of intergroup threat as mediating mechanisms in the link between intergroup contact and intergroup attitudes and behaviors, as well as and in assessing major sources of influence in adolescence – parental, peer and school norms. Participants will be majority and minority (Italian, Serb, Czech and Hungary) elementary and high-school students in Croatia, aged 12-17 (N=1200) and their parents (N=2400). The research combines qualitative and quantitative approach. Qualitative methods (focus groups, interviews and also observations) will be used to get an in-depth insight in the explicit and implicit contact-related school norms. These data will be used further for designing an instrument for measuring contact-related school norms. Quantitative data will be collected in a two-wave longitudinal study, and the effects of interethnic contact on ideological (assimilationism and multiculturalism) and intergroup attitudes and behaviors will be followed. It is proposed to test under what conditions, how and what social norms influence the link between the contact and intergroup attitudes and behaviors and what is the role of the intergroup threat in this context.]]></summary_en></project><project>
<id>3049</id><title_hr><![CDATA[Pravna i ekonomska analiza sustava prevencije pranja novca i financiranja terorizma ]]></title_hr><title_en><![CDATA[Legal and Economic analysis of Anti-Money Laundering and Terrorist financing system ]]></title_en><user_id>12744</user_id><user_firstLast_name>SONJA CINDORI</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2014-09</proposal_call><code>UIP-2014-09-5933</code><acronim><![CDATA[PNFT/AMLTF]]></acronim><duration>01.05.2015 - 30.04.2018</duration><status>Završio</status><financ_value>26.788,83 eur</financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Pravo, Ekonomija, Politologija, </scie_field_hr><scie_field_en>Law, Economy, Political Science, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Pravni fakultet u Zagrebu]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Law]]></institution_en><team_members_id>12804, 12764, 12757, 12756, 12763, 12817, 12755, 18954, 18955, </team_members_id><team_members_names><![CDATA[Ivan Reiner, Miran  Marelja , Meta Ahtik, Luisa Fernanda Bernat Díaz, Ozren Pilipović, Nenad Rančić, Tatjana Kovač Klemar, Jelena Dinić, TAJANA PETROVIĆ, ]]></team_members_names><keywords_hr><![CDATA[pranje novca, financiranje terorizma, analiza, procjena rizika, sumnjive transakcije, ekonometrijski modeli]]></keywords_hr><keywords_en><![CDATA[money laundering, terrorist financing, analysis, risk assessment, suspicious transaction, econometric models]]></keywords_en><summary_hr><![CDATA[Prevencija pranja novca i financiranja terorizma predstavlja novo znanstveno- istraživačko područje koje svojim sadržajem i strukturom podrazumijeva interdisciplinarnost - isprepletenost elemenata pravne podloge njegove prevencije, ekonomskih reperkusija u gospodarstvu te politološkog aspekta problematike pranja novca i financiranja terorizma. Osnovni cilj istraživanja biti će usmjeren na proučavanje zakonitosti djelovanja preventivnih mehanizama borbe protiv pranja novca i financiranja terorizma te poticanja i usmjeravanja stručnih eksperata. Osim pravnog i ekonomskog razmatranja predmetne materije u nacionalnim okvirima, uspostavit će se suradnja sa znanstvenicima iz inozemstva, s Pravnog fakulteta Sveučilišta u Ljubljani (Slovenija) i Ekonomskog fakulteta Sveučilišta Icesi u Caliu (Kolumbija).U cilju širenja spoznaja i produbljivanja suradnje nacionalnih i međunarodnih razmjera, u akademskim okvirima i suradnjom s javnim sektorom, istraživanje će obuhvatiti granu prava u okviru proučavanja financijskog prava, međunarodnog prava i pravne povijesti, dok će međunarodna ekonomija, institucionalna ekonomija i ekonomska analiza prava pružiti empirijsku podlogu znanstvenom istraživanju. Istraživanje će biti usmjereno ka empirijskoj provjeri postojećih znanstvenih teorija i stvaranju novih znanstvenih paradigmi na temelju empirijske analize.]]></summary_hr><summary_en><![CDATA[Prevention of money laundering and terrorism financing is a new scientific field which content and structure imply an interdisciplinary approach - legal approach for money laundering and terrorism financing prevention, economics for the lost revenue in the national economy and political science as another approach to studying the issue of money laundering and terrorist financing. The main aim of the research will focus on studying the legality of preventive mechanisms needed to combat money laundering and terrorist financing and to promote education of existing and new experts in the field. In addition to the legal and economic study of the subject matter at the national and international level,  cooperation with scientists from abroad – namely from Faculty of Law, University of Ljubljana (Slovenia) and Faculty of Economics, University of ICES in Cali (Colombia) will be established. In order to spread knowledge and deepen cooperation at national and international level, both in terms of academic community co-operation with the public sector, the project team will use financial law, international law and legal history for theoretical explanation of anti-money laundering and terrorist financing, while the international economy, institutional economics and economic analysis of law will be used to provide an empirical basis for scientific research.The research will be directed towards empirical verification of existing scientific theories and hopeful establishment of new scientific paradigm based on empirical analysis.]]></summary_en></project><project>
<id>3051</id><title_hr><![CDATA[Specifična obilježja obitelji u riziku: doprinos planiranju kompleksnih intervencija ]]></title_hr><title_en><![CDATA[Specific characteristics of families at risk: contribution to complex interventions planning]]></title_en><user_id>12657</user_id><user_firstLast_name>Antonija  Žižak</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2014-09</proposal_call><code>IP-2014-09-9515</code><acronim><![CDATA[FamResPlan]]></acronim><duration>01.10.2015 - 27.12.2019</duration><status>Završio</status><financ_value>70.766,41 eur</financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Edukacijsko-rehabilitacijske znanosti, Pravo, Sociologija, Psihologija, Socijalne djelatnosti, </scie_field_hr><scie_field_en>Physical education and rehabilitation sciences, Law, Sociology, Psychology, Social work, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Edukacijsko-rehabilitacijski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Education and Rehabilitation Sciences]]></institution_en><team_members_id>12728, 12543, 12929, 12894, 12902, 12723, 12952, 12719, 12958, 13043, 7355, 12909, 12724, 4478, 19034, 25080, 24708, </team_members_id><team_members_names><![CDATA[Ivana Maurović, Miranda Novak, Valentina Kranželić, Anita Jandrić Nišević, Dora Dodig, Martina Lotar Rihtarić, Gabrijela Ratkajec Gašević, Anja Mirosavljević, Martina Ferić, Zoran Zoričić, Ivana Sekol, Nivex Koller-Trbović, Ivana Jeđud Borić, Oliver Kozumplik, Helena Križan, Ljubica Paradžik, Snježana Maloić, ]]></team_members_names><keywords_hr><![CDATA[obitelji u riziku, otpornost, spremnost na promjenu, zadovoljstvo životom, planiranje kompleksnih intervencija]]></keywords_hr><keywords_en><![CDATA[families at risk, resilience, readiness for change, life satisfaction, complex intervention planning]]></keywords_en><summary_hr><![CDATA[Najnovija saznanja ukazuju na potrebu istovremene usmjerenosti intervencijskih sustava za djecu, mlade i odrasle osobe s problemima u ponašanju na pojedinca s problemom i na njegovu obitelj. Stoga stjecanje novih znanja o obiteljima u riziku i razvoj novih intervencija i usluga predstavljaju stalni, kako istraživački, tako i stručni izazov.Opći cilj predloženog istraživanja je utvrditi obilježja specifičnih skupina obitelji u riziku, njihovu otpornost, spremnost na promjenu, spremnost na intervenciju i zadovoljstvo životom, kao set novijih, nedovoljno istraženih procesa koji mogu biti od važnosti za planiranje kompleksnih intervencija za te obitelji. Specifični ciljevi odnose se s jedne strane na razvoj metodologije istraživanja s obiteljima u riziku, a s druge strane na utvrđivanje relacije među navedena obilježja obitelji u riziku, što do sada nije bilo istraživano u Hrvatskoj. Istraživanje će biti provedeno na prigodom uzorku od 200 obitelji u riziku čiji je najmanje jedan član zbog problema u ponašanju korisnik intervencije u području obrazovanja, socijalne skrbi, mentalnog zdravlja i/ili pravosuđa, u Gradu Zagrebu i Zagrebačkoj županiji. Primijenit će se različite metode prikupljanja i analize kvantitativnih i kvalitativnih podataka. Zbog metodološke složenosti te sadržajne i etičke osjetljivosti nacrta istraživanja, projektne aktivnosti provodit će relativno veliki, pomno sastavljen istraživački tim čime su osigurane kompetencije u području znanstvene metodologije, teorijskih i stručnih aspekata istraživanih problema.  Uz nove spoznaje o obilježjima obitelji u riziku, doprinos istraživanja očekuje se i u području razvoja metodologije istraživanja s obiteljima i u obiteljskom okruženju. Ishodi istraživanja omogućit će kreiranje smjernica za planiranje kompleksnih intervencija s obiteljima u riziku temeljem korisničke perspektive i znanstveno utemeljenih podataka.]]></summary_hr><summary_en><![CDATA[Recent findings indicate that intervention systems for children, youth and adults with behavioural problems should focus simultaneously on the individual with the problem and his/her family. Therefore, gaining new knowledge on families at risk and development of new interventions and services present a permanent research and professional challenge.The overall objective of the proposed study is to identify characteristics of specific groups of families at risk, their resilience, readiness for change, readiness for intervention; and life satisfaction, as a set of new, under-researched processes which could be of importance for complex family interventions planning. Specific objectives on one hand relate to the family at risk research methodology development and on the other hand to determine the relationship between the aforementioned characteristics of families at risk, which were never researched in Croatia. The study sample includes 200 families at risk, with at least one family member who is, due to behavioural problems, a beneficiary of interventions in the area of education, social welfare, mental health and/or justice provision in the City of Zagreb and Zagreb County. Various qualitative and quantitative data collection and analysis methods shall be used. Due to the methodological complexity and the sensitivity of the content and research draft ethics, a relatively large, carefully selected research team will conduct the project activities, ensuring competences in the areas of research methodology, theoretical and professional aspects of the issues in focus.  In addition to the new findings on the characteristics of the families at risk, this study will contribute to the family and family environment research methodology development. The outcomes of the study will allow development of guidelines for complex family at risk interventions planning based on beneficiary perspective and scientific data.]]></summary_en></project><project>
<id>3056</id><title_hr><![CDATA[Kako praksom vođeno teorijsko istraživanje u umjetničkoj izvedbi može doprinijeti hrvatskoj znanosti ]]></title_hr><title_en><![CDATA[How Practice-led Research in Artistic Performance Can Contribute to Croatian Science ]]></title_en><user_id>753</user_id><user_firstLast_name>sibila petlevski </user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2014-09</proposal_call><code>IP-2014-09-6963</code><acronim><![CDATA[KPTIUIDHZ/ HPLRAPCCS]]></acronim><duration>15.05.2015 - 14.05.2019</duration><status>Završio</status><financ_value>65.324,77 eur</financ_value><scie_area_hr>Humanističke znanosti, Društvene znanosti, Tehničke znanosti, </scie_area_hr><scie_area_en>Humanities, Social sciences, Technological sciences, </scie_area_en><scie_field_hr>Znanost o umjetnosti, Temeljne tehničke znanosti, Politologija, Sociologija, Filozofija, Filologija, Povijest umjetnosti, Etnologija i antropologija, Kognitivna znanost, Rodni studiji, </scie_field_hr><scie_field_en>Arts, Basic engineering sciences, Political Science, Sociology, Philosophy, Philology, Art history, Ethnology and anthropology, Cognitive science, Gender Studies, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Akademija dramske umjetnosti]]></institution_hr><institution_en><![CDATA[University of Zagreb, Academy of Dramatic Art]]></institution_en><team_members_id>4706, 5264, 3463, 938, 6529, 13046, </team_members_id><team_members_names><![CDATA[Darko Lukić, Josip Stepanić, Laura Potrović, Goran Pavlić, Olga Markič, David Gazarov, ]]></team_members_names><keywords_hr><![CDATA[praksom vođeno istraživanje, umjetnička izvedba, izvedbene umjetnosti, dinamika razmjene, transfer metodologija, sistemsko modeliranje]]></keywords_hr><keywords_en><![CDATA[practice-led research, artistic performance, performing arts, dynamics of exchange, methodology transfer, systems modelling]]></keywords_en><summary_hr><![CDATA[Praksom vođeno istraživanje kao izraz, ovdje se uporablja u potkrjepu tvrdnji da je umjetnička izvedba sama po sebi oblik istraživanja i proizvodi zamjetljive rezultate istraživanja. Zanima nas kako napredak znanja kroz praksu može doprinijeti razvoju inovativnih znanstvenih metodologija. O performativnosti kao konceptu već se dugo raspravlja u okviru društvenih i humanističkih znanosti (u filozofiji jezika, teoriji izvedbe, rodnim studijima, etnografiji, antropologiji, i td.) Izvedba je više nova paradigma nego novi umjetnički oblik; ona se manje odnosi na novi fenomen, a više na novi način gledanja poznatih fenomena. Ona ovdje nije tek puki predmet proučavanja, već je interpretativna rešetka postavljena nad sam proces proučavanja (Carlson). S porastom zanimanja za sve što se pojavljuje na sučelju umjetnosti, znanosti, tehnologije i društva, uloga izvedbenog čina u znanstvenoj praksi i u proizvodnji znanja, danas zadobiva sve više pozornosti. U suvremenom europskome kontekstu, ideja &#39;&#39;performativne znanosti&#39;&#39; obogaćuje se novotehnološkim pristupima u uvidom u problem izvedbene kompleksnosti iz motrišta sistemske znanosti. Glavna je svrha našega istraživanja dati novi zamah istraživanju dinamike razmjene u tijeku umjetničke &#39;&#39;kreacije&#39;&#39;, kao i u proučavanju i reprezentaciji života. Važna hipoteza povezana s navedenim, jest u dokazivanju da dinamika transfera metodologija između umjetnosti i znanosti, metodološki &#39;&#39;interaktivni kontinuun&#39;&#39; (Newman & Benz) i &#39;&#39;petlje njegove povratne sprege&#39;&#39;, mogu olakšati maksimiziranje snage obiju metodologija. Kako bismo doprinijeli pojašnjenju  teorijskih i metodoloških problema, suradnici koji dolaze iz različitih područja istraživanja, pokušat će razviti, verifizirati, vrednovati i uporabiti u simulacijama, formalne modele kvantifikacije dinamike razmjene u tijeku izvedbe: sistemske dinamičke modele i ABM modele. ]]></summary_hr><summary_en><![CDATA[The term practice-led research is here employed to make an argument that artistic performance in itself is a form of research and generates detectable research outputs. We are interested in how advancing knowledge within practice can contribute to the development of innovative scientific methodologies. The concept of performativity has long been discussed within the social sciences and the humanities (in language philosophy, performance theory, gender studies, ethnography, anthropology, etc.). Performance is a new paradigm, not so much a new art form; it stands less for a new phenomenon than for a new observation of familiar phenomena. Here it becomes not only a subject for study but also an interpretive grid laid upon the process of study itself (Carlson). With growing interest in the interface between art, science, technology and society, the role of the performative act within scientific practice and knowledge production receives more attention these days. In the contemporary European context the idea of “performative science” is enriched with new technological approaches and systems science insight into the problem of performance complexity. The main purpose of our research is in giving new scope to exploring the dynamics of exchange in artistic ”creation”, as well as in the study and representation of lives. An important hypothesis, connected to this purpose is to prove that the dynamics of methodology transfer between arts and sciences, the methodological “interactive continuum” (Newman & Benz) and its “feedback loops” facilitate maximizing the strength of both methodologies. In order to contribute to clarification of stated theoretical and methodological problems, collaborators coming from different fields of research will try to develop, verify, validate and use in simulations, the formal models for quantification of dynamics of exchanges within performances: system dynamics model and agent based model. ]]></summary_en></project><project>
<id>3057</id><title_hr><![CDATA[Fitotoksičnost nanosrebra: mehanizmi akcije i interakcije u stanicama duhana]]></title_hr><title_en><![CDATA[Nanosilver phytotoxicity: mechanisms of action and interaction in tobacco cells ]]></title_en><user_id>11303</user_id><user_firstLast_name>Biljana Balen</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2014-09</proposal_call><code>IP-2014-09-6488</code><acronim><![CDATA[NanoPhytoTox]]></acronim><duration>01.05.2016 - 31.10.2021</duration><status>Završio</status><financ_value>112.150,77 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Biologija, Kemija, </scie_field_hr><scie_field_en>Biology, Chemistry, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>4710, 6660, 3121, 4614, 12729, 12785, 21315, 5425, 27557, </team_members_id><team_members_names><![CDATA[Mirta Tkalec, Ana-Marija Domijan, Dubravko Pavoković, Petra Cvjetko, Petra Peharec Štefanić, Sandra Šikić, Renata Biba, Dora Markulin, Karla Košpić, ]]></team_members_names><keywords_hr><![CDATA[nanosrebro, biotransformacija, biomarkeri, stanična ultrastruktura, omotači, oksidacijski stress, proteomika, mehanizmi toksičnosti]]></keywords_hr><keywords_en><![CDATA[nanosilver, biotransformation, biomarkers, cell ultrastructure, coatings, tobacco, oxidative stress, proteomics, toxicity mechanisms]]></keywords_en><summary_hr><![CDATA[Male dimenzije nanočestica (NPs), rezultiraju jedinstvenim kemijskim i fizikalnim značajkama, zbog čega se one proizvode u velikim količinama i koriste u različitim proizvodima. Zbog široke upotrebe nanosrebra (AgNPs), najzastupljenijeg nanomaterijala koji ima protubakterijska i protugljivična svojstva, raste zabrinutost glede mogućih štetnih učinaka na okoliš. Do sada je objavljeno nekoliko toksikoloških studija na česticama AgNP, no još uvijek je teško donijeti konačne zaključke o njihovoj toksičnosti. AgNPs su sklone (bio)transformaciji, koja mijenja njihova svojstva i još uvijek nije jasno potječe li toksičnost od samih nanočestica ili od otpuštenih iona Ag+. Biljke kao vitalan dio ekološkog sustava imaju važnu ulogu u transportu i bioakumulaciji toksičnih tvari u hranidbeni lanac. No, studije fitotoksičnosti AgNP su malobrojne i manjkave. Nadalje, nedostaju i podaci o učincima AgNPs na važne stanične procese. Stoga u ovom projektu želimo otkriti i objasniti toksične učinke nekoliko različitih tipova AgNPs na biljke, što će doprinijeti procjeni okolišnog rizika izlaganja nanosrebru. Kao modelni organizam predlažemo duhan, ekonomski važnu biljku često korištenu u istraživanjima abiotičkog stresa. Testirat ćemo AgNPs stabilizirane različitim omotačima, kako bi otkrili utječu li različite osobine ovih nanočestica na njihovu toksičnost. Kako bismo ustanovili potječe li toksičnost AgNPs od oslobođenih iona Ag+ ili od samih nanočestica, odredit ćemo stabilnost i biotransformaciju AgNPs i ustanoviti ulaze li nanočestice u biljno tkivo odnosno stanicu. Nadalje, utvrdit ćemo ulogu oksidacijskog stresa u mehanizmu toksičnosti nanosrebra te dolazi li tijekom izlaganja nanosrebru do promjene u sastavu proteina. Na temelju dobivenih rezultata definirat ćemo biomarkere fitotoksičnosti AgNPs koji bi se mogli koristiti u biomonitoringu okoliša. Dobiveni rezultati moći će se primijeniti za procjenu sigurnosti korištenja nanočestica srebra.]]></summary_hr><summary_en><![CDATA[The small size of nanoparticles (NPs) results in unique chemical and physical characteristics, which is why they are produced in large quantities for implementation in various products. Due to widespread use of silver nanoparticles (AgNPs), the dominating nanomaterial with antibacterial and antifungal properties, there is a concern regarding its potential detrimental impacts on the environment. Although there have been a lot of toxicological studies published on AgNPs, it is still difficult to draw conclusions about their toxicity. AgNPs are prone to (bio)transformation, which modifies their properties and it is not clear whether toxicity results from the nanoparticles or from Ag+ dissociation. Besides being the vital part of healthy ecosystems, plants play a significant role in transport and bioaccumulation of toxic substances in food chains, but toxicological studies of AgNPs conducted on plants are scare and inconclusive. Moreover, there is a lack of information about effects of AgNPs on important cellular processes. Therefore, in this project we aim to reveal and explain the toxicity of a set of diverse AgNPs to plants in order to contribute to the environmental hazard assessment of AgNP. As the model organism we propose tobacco, an economically interesting plant, frequently used in stress research. We will investigate AgNPs with different coatings, used to enhance NP stability, to reveal whether those characteristics are determinants of toxicity. Stability and biotransformation of AgNPs as well as their uptake in the cells will be studied and correlated with AgNPs-induced effects to distinguish between particle and Ag+ toxicity. We will establish the involvement of oxidative stress in the mechanism of toxicity as well as possible proteomic changes. The results will be used to define biomarkers of AgNP-induced phytotoxicity, which could be useful for environmental biomonitoring. Also, results can be applied to estimate the possibility of use and safety of AgNPs.]]></summary_en></project><project>
<id>3061</id><title_hr><![CDATA[Uloga stresnog proteina Hsp70 u imunosno-upalnom odgovoru kod kronične opstrukcijske plućne bolesti]]></title_hr><title_en><![CDATA[The role of stress protein Hsp70 in immune and inflammatory responses in chronic obstructive pulmonary disease]]></title_en><user_id>12345</user_id><user_firstLast_name>Lada Rumora</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2014-09</proposal_call><code>IP-2014-09-1247</code><acronim><![CDATA[Hsp70COPD]]></acronim><duration>01.12.2015 - 30.11.2019</duration><status>Završio</status><financ_value>132.720,55 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, Farmacija, </scie_field_hr><scie_field_en>Basic Medical Sciences, Pharmaceutical sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Farmaceutsko-biokemijski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Pharmacy and Biochemistry]]></institution_en><team_members_id>13256, 3520, 12546, 2629, 12800, 13149, 12859, 7144, 3452, 12717, 3517, 20407, 25103, </team_members_id><team_members_names><![CDATA[Ivana Čepelak, Andrea Hulina, Anita Somborac Bačura, Tihana Žanić Grubišić, DANIELA JAKŠIĆ DESPOT, Dubravko Jelić, Martina Bosnar, Sanja Popović-Grle, Miroslav Samarzija, Heijink Irene Hilde, Marija Grdić Rajković, Andrea  Vukić Dugac, Iva Hlapčić, ]]></team_members_names><keywords_hr><![CDATA[Hsp70, KOPB, upala, TLR, NLRP3 inflamasom, signalne molekule, stanično umiranje, biomarkeri]]></keywords_hr><keywords_en><![CDATA[Hsp70, COPD, inflammation, TLR, NLRP3 inflammasome, signalling molecules, cell death, biomarkers]]></keywords_en><summary_hr><![CDATA[Kroničnu opstrukcijsku plućnu bolest (KOPB) karakterizira stalno ograničenje protoka zraka koje je povezano s pojačanom kroničnom upalom.Glavna hipoteza ovog istraživanja je da je pojačan imunosno-upalni odgovor posljedica povišenih koncentracija izvanstaničnog Hsp70 (eHsp70) u bolesnika s KOPB-om.Cilj in vitro istraživanja ispitati je mehanizam djelovanja eHsp70 na plućnim i krvnim stanicama. Stoga će se pratiti aktivacija TLR2 i TLR4 receptora, NLRP3 inflamasoma i signalnih molekula MAPK i NF-kappaB, koje potiču otpuštanje upalnih citokina (TNFalpha, IL-6, IL-1alpha, IL-1beta). Kako bi se razjasnilo funkcionalno značenje aktivacije navedenih molekula, koristit će se specifični agonisti, antagonisti i inhibitori. Također će se istraživati citotoksičnost eHsp70 te će se proučiti različiti načini umiranja stanica (apoptoza, nekroptoza, piroptoza).Cilj ex vivo istraživanja ispitati je povezanost eHsp70 i drugih upalnih parametara s klinički značajnim ishodima KOPB-a. Predloženo istraživanje longitudinalno je praćenje sistemskih upalnih biomarkera u skupinama bolesnika u stabilnoj fazi KOPB-a te zdravih ispitanika (pušača i nepušača). Spirometrijska mjerenja vršit će se jednom godišnje tijekom tri godine, a krv će se vaditi na početku istraživanja i nakon godine dana. Genska komponenta bolesti istražit će se ispitivanjem ekspresije (RT-qPCR) i polimorfizama (PCR-RFLP) gena za Hsp70, TLR2 i TLR4. Sistemska upala ispitat će se određivanjem upalnih DAMP molekula (eHsp70, eATP, IL-1alpha), citokina (TNFalpha, IL-6, IL-1beta) te općih upalnih biomarkera (leukociti, CRP, fibrinogen).Smatramo da će rezultati ovog istraživanja doprinijeti boljem razumijevanju sistemskog upalnog fenotipa u KOPB-u te da će pripomoći individualizaciji terapijskog pristupa kao i poboljšanju značajnih kliničkih ishoda KOPB-a.]]></summary_hr><summary_en><![CDATA[Chronic obstructive pulmonary disease (COPD) is characterized by persistent airflow limitation associated with an enhanced chronic inflammation.Main hypothesis of our research is that strong activation of immune and inflammatory responses is result of increased levels of extracellular Hsp70 (eHsp70) in COPD patients.The objective of in vitro investigations is to explore underlying mechanisms of eHsp70 effects in pulmonary and peripheral blood cells. Therefore we will monitor activation of TLR2 and TLR4 receptors, NLRP3 inflammasome, and signalling molecules MAPKs and NF-kappaB, important for pro-inflammatory cytokines release (TNFalpha, IL-6, IL-1alpha, IL-1beta). To elucidate the functional significance of molecules’ activation in eHsp70-induced inflammation, we will use specific agonists, antagonists and inhibitors. We will also explore eHsp70 cytotoxicity and differentiate between various modes of cell death (apoptosis, necroptosis, pyroptosis).The objective of ex vivo investigations is to associate eHsp70 and other pro-inflammatory parameters with clinically relevant COPD outcomes. The proposed study provides longitudinal investigations of systemic inflammatory biomarkers in stabile COPD patients, and smoking and non-smoking controls. Spirometry measurements will be performed annually during three year follow up, and blood will be collected at the recruitment and after one year. Genetic component of the disease will be explored by assessing expression (RT-qPCR) and polymorphisms (PCR-RFLP) of Hsp70, TLR2 and TLR4 genes. Systemic inflammation will be evaluated by pro-inflammatory DAMPs (eHsp70, eATP, IL-1alpha), cytokines (TNFalpha, IL-6, IL-1beta) and general biomarkers (leukocytes, CRP, fibrinogen) determination.We believe that obtained results will provide new information on the systemic inflammatory COPD phenotype, which might help to individualize therapeutic strategy, and to improve relevant clinical outcomes of the disease.]]></summary_en></project><project>
<id>3067</id><title_hr><![CDATA[Razvoj supramolekulskih receptora kationa i aniona]]></title_hr><title_en><![CDATA[Development of Supramolecular Receptors for Cations and Anions]]></title_en><user_id>7690</user_id><user_firstLast_name>Vladislav Tomišić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2014-09</proposal_call><code>IP-2014-09-7309</code><acronim><![CDATA[SupraCAR]]></acronim><duration>01.06.2015 - 31.05.2019</duration><status>Završio</status><financ_value>127.413,90 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, </scie_field_hr><scie_field_en>Chemistry, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>4270, 12766, 12769, 5334, 12384, 2558, 12733, 11281, 2593, 3260, </team_members_id><team_members_names><![CDATA[Branimir Bertoša, Nikola Cindro, Renato Tomaš, Josip Požar, Gordan Horvat, Marina Tranfić Bakić, Nikola Bregović, Vlatka Gvozdić, Marijana Jukić, Katarina Pičuljan, ]]></team_members_names><keywords_hr><![CDATA[receptori iona, kaliksareni, dehidracetna kiselina, kompleksiranje, solvatacija, vodikove veze, termodinamika  ]]></keywords_hr><keywords_en><![CDATA[ion receptors, calixarenes, dehydroacetic acid, complexation, solvation, hydrogen bonding, thermodynamics]]></keywords_en><summary_hr><![CDATA[Razvoj efikasnih i selektivnih receptora nabijenih kemijskih vrsta od velike je važnosti. U okviru ovog projekta dizajnirat će se, sintezirati i karakterizirati brojni takvi spojevi. Priredit će se niz novih derivata kaliksarena koji bi trebali efikasno i selektivno vezati razne katione i anione. Neki od tih spojeva predviđeni su da mogu poslužiti u analitičke svrhe, posebice kao ekstraktanti, drugi će sadržavati fluorescentne ili aminokiselinske podjedinice, dok će prilikom dizajna jednog dijela kaliksarenskih derivata posebna pažnja biti usmjerena poboljšanju njihove topljivosti u vodi. Također će se prirediti niz derivata dehidracetne kiseline kao anionskih receptora koji će sadržavati aminske, amidne, ureidne i tioureidne podjedinice. Kompleksacijski afiniteti svih navedenih spojeva prema raznim supstratima proučit će se sveobuhvatnim pristupom koji uključuje termodinamička, komputacijska i strukturna istraživanja. Koristit će se brojne spektroskopske i elektrokemijske metode, kao i (mikro)kalorimetrija, što će omogućiti određivanje pouzdanih termodinamičkih podataka (konstante stabilnosti, standardne Gibbsove energije, entalpije i entropije reakcija kompleksiranja i otapanja). Bit će provedene i simulacije molekulske dinamike istraživanih sustava, što će pripomoći dizajnu novih spojeva te interpretaciji eksperimentalnih nalaza. Pored toga, uz rezultate postignute spektroskopijom NMR te rentgenskom strukturnom analizom, te će simulacije pružiti uvid u strukturne karakteristike receptora i njihovih kompleksa. Posebna će pažnja biti posvećena utjecaju vodikovih veza i solvatacije na ravnoteže reakcija kompleksiranja. U tu svrhu koristit će se brojna otapala različitih solvatacijskih svojstava i afiniteta za stvaranje vodikovih veza. Očekuje se da će dobivene termodinamičke informacije omogućiti stjecanje detaljnog uvid u reakcije kompleksiranja, kao i utjecaj otapala na njihov ishod, što bi trebalo olakšati i ubrzati daljnji razvoj supramolekulskih receptora.]]></summary_hr><summary_en><![CDATA[The importance of development of efficient and selective receptors of charged species has been widely recognised. In the framework of this project, a variety of such compounds will be designed, synthesised, and characterised. A series of novel calixarene derivatives capable of strongly and selectively binding cations and anions will be prepared. Some of these compounds are aimed to be efficient liquid-liquid extraction agents whereas the others will be designed to be water-soluble or to bear fluorescent and amino-acid substituents. Another class of anion receptors which will be synthesised comprises amine, amide, urea, and thiourea derivatives of dehydroacetic acid. The complexation abilities of all the compounds mentioned towards various substrates will be explored by using an integrated approach which includes thermodynamic, computational, and structural studies. A number of spectroscopic and electrochemical methods as well as (micro)calorimetry will be employed. That should yield detailed and reliable thermodynamic data (stability constants, reaction and solution Gibbs energies, enthalpies and entropies). In order to facilitate the design of the targeted molecules and to assist the interpretation of the experimental results, the molecular dynamics simulations of the systems studied will be carried out. This will, together with the results of NMR studies and that of solid-state X-ray diffraction investigations, also ensure information about structural characteristics of the receptors and their complexes. Particular attention will be focused on the hydrogen-bonding and solvation effects on the equilibria of binding reactions. For that reason, many solvents with different solvation and hydrogen-bonding affinities will be used. The obtained thermodynamic information is expected to provide a detailed insight into the complexation processes and the influence of medium on the reactions studied, which will allow further development of efficient supramolecular receptors.]]></summary_en></project><project>
<id>3070</id><title_hr><![CDATA[Vojnički život i slike ratnika u hrvatskom pograničju od 16. stoljeća do 1918.]]></title_hr><title_en><![CDATA[Military Life and Warrior Images in Croatian Borderlands from the 16th Century until 1918]]></title_en><user_id>265</user_id><user_firstLast_name>Alexander Buczynski</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2014-09</proposal_call><code>IP-2014-09-3675</code><acronim><![CDATA[MLWICB]]></acronim><duration>01.05.2015 - 30.04.2019</duration><status>Završio</status><financ_value>73.501,89 eur</financ_value><scie_area_hr>Humanističke znanosti, Društvene znanosti, </scie_area_hr><scie_area_en>Humanities, Social sciences, </scie_area_en><scie_field_hr>Povijest, Sociologija, Demografija, </scie_field_hr><scie_field_en>History, Sociology, Demography, </scie_field_en><institution_hr><![CDATA[Hrvatski institut za povijest]]></institution_hr><institution_en><![CDATA[Croatian Institute of History]]></institution_en><team_members_id>382, 461, 401, 532, 418, 338, 1172, 1389, 1078, 3212, 12934, 13032, 13197, 1501, 21408, </team_members_id><team_members_names><![CDATA[Lovorka Čoralić, Stjepan Matković, Maja Katušić, Vedran Klaužer, Filip Novosel, Ruža Radoš, Tado Oršolić, Nikola Markulin, Domagoj Madunić, Juraj Balić, Vlad Vasile Popovici, D.B.G Heuser, Ferenc Végh, Arijana Kolak Bosnjak, Goran Ovčariček, ]]></team_members_names><keywords_hr><![CDATA[kulturna povijest, povijesna demografija, Habsburška Monarhija, Venecija, Vojna krajina, Dalmacija, gerila, vojni popisi, vojna revolucija, novine]]></keywords_hr><keywords_en><![CDATA[cultural history, historical demography, Habsburg Monarchy, Venice, Military Frontier, Dalmatia, guerilla, muster rolls, military revolution, news]]></keywords_en><summary_hr><![CDATA[Prinosi vojnika s hrvatskog pograničja u vojnim postrojbama Habsburške Monarhije, Mletačke Republike, Osmanskog Carstva i Francuskog Carstva neprijeporna su činjenica. Zahvaljujući opsežnom i vremenski kontinuirano sačuvanom arhivskom gradivu koje se odnosi na razdoblje ranog novog vijeka i dugog 19. stoljeća, ta se problematika može sustavno istraživati primjenom multidisciplinarnih metoda. Cilj ovog projekta je istražiti demografske, društveno-ekonomske i političke prilike u hrvatskom pograničju, kao i utvrditi uzročno-posljedične veze između navedenih prilika (razvojnih sastavnica) koje su činile svakodnevnicu hrvatskih vojnika i kreirale njihov identitet. Istraživanje će se usredotočiti na Ličku i Otočku pukovniju u Vojnoj krajini, Zadar i Kotor kao središnja mletačka vojna uporišta na istočnoj obali Jadrana, Dubrovačku Republiku te Dalmaciju u vrijeme austrijske i francuske uprave. Rekonstrukcija svakodnevice i identiteta pripadnika vojničkog društva objedinit će: 1. demografska kretanja (natalitet, fertilitet i mortalitet), migracije, društveno-ekonomski kontekst (dobna, spolna i profesionalna struktura); 2. vojni i ratni kontekst (vojna organizacija i obuka, “mali rat“ – “partizanski način ratovanja“ – umijeće ratovanja, imidž i samosvijest hrvatskih vojnika); 3. geo-politički kontekst (upravno-pravna podjela, tranzicije vlasti). Jedan od temeljnih ciljeva istraživačkog tima jest znanstveno obraditi te kroz bazu podataka prikazati što veći broj vojnih popisa, matičnih knjiga, popisa stanovništva, popisa stradalnika, zemljišnih knjiga koji se odnose na Ličku i Otočku pukovniju, Zadar, Dubrovačku Republiku i Kotor. Rečeni bi izvori, odnosno podatci, bili kreirani i dostupni u on-line bazi otvorenog pristupa te integrirani u svjetske mreže sličnih baza kao što su EHPS-Net i MOSAIC i kao takvi služili bi multidisciplinarnoj svrsi.]]></summary_hr><summary_en><![CDATA[The contribution of soldiers from Croatian borderlands to the armed forces of the Habsburg Monarchy, Republic of Venice, Ottoman Empire and French Empire is beyond dispute. Thanks to comprehensive and continuous archive records relevant to the early modern period and long nineteenth century, this issue can be thoroughly researched on a multidisciplinary level. This project aims to explore demographic, socio-economic and political circumstances in Croatian borderlands, and to examine cause and effect relationships between these circumstances (developmental components) that made up the everyday life of Croatian soldiers, their families and households, and formed their identity. Research will focus on the Otočac and Lika Regiments of the Military Frontier, Zadar and Kotor as central strongholds of the Republic of Venice on the East Adriatic, the Republic of Dubrovnik and Dalmatia during the French and Austrian administration. The reconstruction of everyday life and the identity of the martial people that inhabited these borderlands will include: 1. demographic data (birth rates, fertility and mortality), migrations and the socio-economic context (age, gender and professional structure); 2. the military and war context (military organization and training, la petite guerre - partisan warfare - and the art of war, images and self-awareness of Croatian soldiers); 3. the geo-political context (administrative and legal organization, government transitions). One of the main objectives of the research team is to process a large quantity of muster rolls and other military lists, birth, marriage and death registers, casualty lists, land registers etc, covering the Otočac and Lika Regiments, Zadar, Dalmatia, Republic of Dubrovnik and Kotor in order to create an open access database that can be integrated within networks as EHPS-Net and MOSAIC and will thus serve a multidisciplinary purpose.]]></summary_en></project><project>
<id>3073</id><title_hr><![CDATA[Potencijali i prepreke razvoja socijalnih supermarketa u Srednjoj i istočnoj Europi]]></title_hr><title_en><![CDATA[Potentials and obstacles of Social Supermarkets Development in Central and Eastern Europe]]></title_en><user_id>11297</user_id><user_firstLast_name>Blaženka Knežević</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2014-09</proposal_call><code>UIP-2014-09-4057</code><acronim><![CDATA[SSMCEE]]></acronim><duration>01.06.2015 - 31.05.2018</duration><status>Završio</status><financ_value>60.258,84 eur</financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Ekonomija, Socijalne djelatnosti, </scie_field_hr><scie_field_en>Economy, Social work, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Ekonomski fakultet u Zagrebu]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Economics and Business]]></institution_en><team_members_id>13165, 13604, 13624, 13029, 13258, 6450, 13693, 13726, 13707, 13589, 13713, 13733, 13735, 13734, 13745, 13744, 21404, </team_members_id><team_members_names><![CDATA[Anita Pavković, Zoran Šućur, SANDA RENKO, Petra Škrobot, Mia  Delić, Ivana Marić, Wach Krzysztof, Marek Szarucki, Vida Davidavičiene, MAJA KLINDŽIĆ, Nika Šimurina, Jurgita  Raudeliuniene, Zoran Bogetić, Grazyna  Śmigielska, Goran Petković, Jelena Stankevičiene , Eva  Pavic, ]]></team_members_names><keywords_hr><![CDATA[maloprodaja, oblici maloprodaje, društvena odgovornost, socijalni supermarketi, socijalne inovacije]]></keywords_hr><keywords_en><![CDATA[retailing, retail formats, social responsibility, social supermarkets, social innovations]]></keywords_en><summary_hr><![CDATA[Ekonomska kriza uzrokovala je porast nezaposlenosti i povećanje siromaštva u Europskoj uniji. S druge strane, tradicionalni kanali distribucije obično stvaraju viškove koji se mogu učinkovitije iskoristiti. Istraživanja pokazuju da socijalne samoposluge, kao novi maloprodajni oblik, postaju sve važniji čimbenik u smanjenju siromaštva u cijeloj Europi putem učinkovitije raspodjele stvorenih viškova roba. Socijalne samoposluge po svojoj osnovnoj svrsi i načinu poslovanja, značajno se  razlikuju u odnosu na tradicionalne maloprodajne oblike, a u postojećoj znanstvenoj literaturi još uvijek nisu istražene u dovoljnoj mjeri, posebice u zemljama Srednje i istočne Europe. Kako socijalne samoposluge temelje svoje djelovanje na filantropskim osnovama, volontiranju i donacijama, a već na nekim tržištima značajno utječu na strukturu prihoda tradicionalnih maloprodavača, ova tema zahtijeva multidisciplinarni pristup kako bi se: (a) pojasnila njihova trenutna pozicija i njihov utjecaj na opću socio-ekonomsku situaciju na pojedinim tržištima, (b) istražio pravni okvir koji je utemeljen u onim zemljama u kojima su socijalni supermarketi postigli visok stupanj razvoja, posebno u području poreznog zakonodavstva i zakonodavstva prava potrošača, (c) istaknula pitanja upravljanja u vezi organizacije rada volontera ili zaposlenika, i (d) objasnili specifični problemi učinkovite organizacije ulazne logistike te distribucije roba i usluga unutar socijalnih supermarketa. Zato će projektni tim obuhvatiti stručnjake iz područja trgovine, upravljanja maloprodajom, upravljanja neprofitnim organizacijama, korporativnih financija, fiskalnih sustava i socijalnog rada iz nekoliko znanstvenih institucija iz četiri države Srednje i istočne Europe.]]></summary_hr><summary_en><![CDATA[The ongoing economic crisis caused the rising unemployment and the increasing poverty in the European Union. On the other hand, the traditional distribution channels usually generate surpluses that can be effectively used to decrease problems of poverty. Research studies show that Social supermarkets, as a new retail, are becoming increasingly important factor in reducing poverty across Europe throughout more efficient distribution of generated surpluses of goods. Social supermarkets at their core purpose and mean of operations are substantially different compared to the traditional retail formats, and in the current scientific literature they have not been sufficiently investigated so far, especially in Central and Eastern European countries. As social supermarkets base their operation on philanthropic foundations, volunteering and donations, and already in some markets significantly affect the structure of revenues of the traditional retailers, this topic requires a multidisciplinary approach in order: (a) to clarify their current position and their impact the general socio-economic situation in the particular markets, (b) to investigate the legal framework that has been established by those countries in which social supermarkets reached a high level of development, particularly in the area of tax legislation and consumer rights legislation, (c) to assess management issues regarding work organization of volunteers or employees, and (d) to explain particular problems of the effective organization of input logistics and distribution of goods and services within social supermarkets. Therefore, the project team will include experts from the fields of retailing, retail management, management of nonprofit organizations, corporate finance, fiscal systems and social work from several scientific institutions from four Central and Eastern European countries.]]></summary_en></project><project>
<id>3076</id><title_hr><![CDATA[Molekularni mehanizmi alternativne raspodjele elektrona u fotosintezi]]></title_hr><title_en><![CDATA[Exploring novel molecular mechanisms of alternative electron partitioning in photosynthesis]]></title_en><user_id>455</user_id><user_firstLast_name>Hrvoje Fulgosi</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2014-09</proposal_call><code>IP-2014-09-1173</code><acronim><![CDATA[PHOTOSYNTH]]></acronim><duration>01.09.2015 - 30.11.2019</duration><status>Završio</status><financ_value>132.722,81 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Biologija, </scie_field_hr><scie_field_en>Biology, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>1001, 998, 1266, 5629, 25066, </team_members_id><team_members_names><![CDATA[Lea Vojta, Hrvoje Lepeduš, Sonja Veljović Jovanović, Wolfgang Bilger, Marija Vidović, ]]></team_members_names><keywords_hr><![CDATA[oksigena fotosinteza, kloroplasti, tok elektrona, FNR, ROS, rodanaza, sortiranje proteina, transgenične biljke, Arabidopsis thaliana]]></keywords_hr><keywords_en><![CDATA[oxygenic photosynthesis, chloroplasts, electron flow, FNR, ROS, rhodanese, protein sorting, transgenic plants, Arabidopsis thaliana]]></keywords_en><summary_hr><![CDATA[Konačni prijenos fotosintetskih elektrona s feredoksina na NADP+ odvija se putem enzima feredoksin:NADP+ oksidoreduktaze (FNR). FNR je privučen na tilakoide pomoću integralnog proteina tilakoidnih membrane sličnog rodanazama, TROL-a, i solubilnog proteina Tic62. TROL je nedavno okarakterizirala naša grupa. FNR također predstavlja poveznicu između svjetlosnih reakcija i generalnog metabolizma (kao što je fiksacija ugljika, metabolizam dušika, biosinteza masnih kiselina i klorofila). U ovom projektu pratimo sudbinu elektrona nizvodno od fotosustava I u odsustvu TROL-a. Da bismo proučili in vivo funkcije TROL-a i njegovih domena koristit ćemo genski “knock-out” i “knock-in” pristup u modelnoj biljci Arabidopsis thaliana. Naša hipoteza je da je FNR-TROL interakcija dinamičma, slična interakciji FNR-Tic62, i usklađena s mijenjanjem uvjeta osvjetljenja u okolišu. Nadalje, predlažemo da je lumenu izložena rodanazna domena TROL-a uključena u prepoznavanje redoks signala, dok je prolinom bogata pokretna spona, ispred motiva koji veže FNR za membranu, odgovorna za dinamičko vezanje FNR-a i/ili privlačenje FNR-a u različite membranske domene. Koristit ćemo razrađene biokemijske i biofizičke pristupe za kvantifikaciju stvaranja slobodnih radikala i protoka i raspodjele elektrona u različitim mutantama TROL-a. Cilj nam je pokazati da je točka grananja TROL-FNR integrirana u biljni odgovor na stress. Također, želimo pokazati da dinamičko vezanje i otpuštanje FNR-a s TROL-a može kontrolirati protok elektrona prije aktivacije puta pseudocikličkog prijenosa elektrona. Ovaj mehanizam vjerojatno nije uočen u dosadašnjim modelima toka elektrona u oksigenoj fotosintezi.]]></summary_hr><summary_en><![CDATA[In photosynthesis, final electron transfer from ferredoxin to NADP+ is accomplished by the flavo enzyme ferredoxin:NADP+ oxidoreductase (FNR). FNR is recruited to thylakoid membranes via integral membrane thylakoid rodanese-like protein TROL and soluble Tic62. TROL protein has recently been characterized by our group. FNR also represents a link between light-driven reactions and general metabolism (e.g. carbon fixation, nitrogen metabolism and fatty acid and chlorophyll biosynthesis). In this project, we address the fate of electrons downstream of photosystem I when TROL is absent. We will employ gene knock-out and knock-in approaches in the model plant Arabidopsis thaliana to study in vivo functions of TROL and its domains. We hypothesize that the interaction of FNR with TROL is dynamic, similar to FNR-Tic62 association, and in synchrony with changing environmental light conditions. Further, we propose that thylakoid lumen-exposed rhodanese domain of TROL is involved in perception of redox signals, while proline-rich swivel preceding FNR membrane attachment motif is responsible for the dynamic FNR biding and/or recruitment of FNR into different membrane domains. We will use elaborate biochemical and biophysical approaches to quantify free radical formation and electron flow and partitioning in various TROL mutants. We will aim to demonstrate that TROL-FNR branch point is integrated into plant stress responses. Finally, we want to demonstrate that the dynamic binding and release of FNR from TROL can control the flow of electrons prior to activation of the pseudo-cyclic electron transfer pathway. This mechanism may have been overlooked in present models of electron flow in oxygenic photosynthesis. ]]></summary_en></project><project>
<id>3079</id><title_hr><![CDATA[Sirtuin3 kao posrednik mitohondrijske funkcije u estrogen-ovisnoj otpornosti na oksidativni stres i prehranu s visokim udjelom masti]]></title_hr><title_en><![CDATA[Sirtuin 3 as a mediator of mitochondrial function in estrogen-dependent resistance to oxidative stress and high-fat diet]]></title_en><user_id>656</user_id><user_firstLast_name>Tihomir  Balog</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2014-09</proposal_call><code>IP-2014-09-4533</code><acronim><![CDATA[SuMERA]]></acronim><duration>01.09.2015 - 31.01.2020</duration><status>Završio</status><financ_value>131.429,21 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, Kliničke medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, Clinical sciences, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>703, 3299, 660, 3410, 3543, 3434, 941, 21332, </team_members_id><team_members_names><![CDATA[Sandra Sobočanec, Marina Korolija, Željka  Mačak Šafranko, Marijana  Popović Hadžija, Borka Kušić, Ivana Grbeša, Ana Šarić, Iva Škrinjar, ]]></team_members_names><keywords_hr><![CDATA[sirtuini, mitohondriji, estrogen, RKV, starenje, oksidativni stres]]></keywords_hr><keywords_en><![CDATA[sirtuin, mitochondria, estrogen, ROS, aging, oxidative stress]]></keywords_en><summary_hr><![CDATA[Sirtuini čine obitelj proteina koji imaju važnu i dobro istraženu ulogu za regulaciju procesa starenja u kvascima i D. melanogaster. U višim organizmima njihova je uloga u starenju znatno slabije istražena. Sirtuin 3 (SIRT3) je jedini član porodice proteina SIRT čija se aktivnost može povezati sa dužinom života u ljudi. SIRT3 je glavni regulator mitohondrijske funkcije, te ima važnu ulogu u održavanju oskidacijsko-redukcijske ravnoteže u mitohondrijima. Poremećaj oksidacijsko-redukcijske ravnoteže u stanici zbog povećanog stvaranja reaktivnih kisikovih vrsta (ROS), uzrokuje oksidacijski stres koji za posljedicu ima oksidacijska oštećenja proteina, lipida i nukleinskih kiselina, te doprinosi smanjenu mitohondrijske funkcije. Progresivno nakupljanje oksidacijskih oštećenja u stanici i slabljenje funkcije mitohondrija prethodi nastanku bolesti povezanih sa starenjem. Ženski spol općenito, pokazuje manji stupanj pojavnosti bolesti i patologija povezanih sa starenjem, što se pripisuje zaštitnoj ulozi ženskih spolnih hormona, u prvom redu estrogena (E2). Uloga E2 u zaštiti stanica od štetnog djelovanja reaktivnih vrsta utvrđena je na velikom broju modela. Poznato je da E2 svoju zaštitnu ulogu ostvaruje prvenstveno pojačavajući učinkovitost pretvorbe energije u mitohondrijima i aktivacijom zaštitnih mehanizama u stanici, međutim nije poznato sudjeluje li u tim procesima protein SIRT3. Naš cilj utvrditi ulogu proteina SIRT3 u zaštiti stanica od oksidacijskog stresa posredovanoj estrogenom na modelima in vitro i in vivo.U svrhu određivanja povezanosti između SIRT3, te zaštitnog učinka estrogena na funkciju mitohondrija i otpornost na oksidacijski stres, planiramo koristiti farmakološki, nutritivni i genetički pristup. Uspješan završetak planiranog projekta znatno bi doprinjeo razumijevanju mehanizama djelovanja mitohondrijskog proteina SIRT3, te njegove uloge kao potencijalne farmakološke ciljne molekule. Nadalje, razumjevanije razlika između zaštitnog i štetnog djelovanja estrogena nužan je preduvjet za razvoj lijekova koji bi pomogli u liječenju i sprečavanju bolesti povezanih sa starenjem, kod kojih bi štetan utjecaj estrogena bio sveden na minimum. ]]></summary_hr><summary_en><![CDATA[Sirtuin protein family is found to be involved in aging process in yeast and D. melanogaster, while their role in higher organisms is less explored. Sirtuin3 (SIRT3) is the only member of sirtuin family linked to longevity in humans. In addition, important cellular and mitochondrial processes, including reactive oxygen species (ROS) generation are integrated through SIRT3. The excessive production of ROS leads to oxidative stress, a crucial event that contributes to mitochondrial dysfunction and age-related pathologies. Females show lower incidence of some age-related diseases that is attributed to protective effect of sex hormones. Estrogen (E2), a female sex hormone, has well established cytoprotective effect during oxidative stress. However, the mechanisms by which E2 is protective remains elusive. Although E2-dependent protection includes improvement of mitochondrial function, it is not clear whether SIRT3 participates in these events. We propose that sex-related resistance to oxidative stress occurs by E2-dependent improvement of mitochondrial function, mediated by SIRT3. We aim to define the role of SIRT3 on mitochondrial function in E2-dependent resistance to oxidative stress both in vitro and in vivo. To validate this hypothesis we will utilize pharmacological, dietary and genetic approaches to establish role of SIRT3 in E2-dependent resistance to oxidative stress. These informations will indicate if direct link between E2, SIRT3, mitochondrial function and resistance to oxidative stress exists. Successful completion of these specific aims will contribute to mechanistic understanding of the role of mitochondrial fidelity protein SIRT3, as a potential pharmacological target. Moreover, distinguishing the pathways involved in beneficial and detrimental effects of E2 is crucial for developing drug therapies that will help to retard aging with only minimal deleterious effects caused by E2]]></summary_en></project><project>
<id>3080</id><title_hr><![CDATA[Minimalni umjetni enzimi: Proširenje primjene &#39;&#39;posredne indukcije&#39;&#39; na nove supstrate i nove asimetrične reakcije]]></title_hr><title_en><![CDATA[Minimal Artificial Enzymes: Expanding the Application of &#39;&#39;Backdoor Induction&#39;&#39; through new Substrates and new Asymmetric Reactions]]></title_en><user_id>355</user_id><user_firstLast_name>Srećko Kirin</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2014-09</proposal_call><code>IP-2014-09-1461</code><acronim><![CDATA[MArtEn]]></acronim><duration>01.06.2015 - 30.09.2019</duration><status>Završio</status><financ_value>104.187,40 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, </scie_field_hr><scie_field_en>Chemistry, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>3009, 2927, 368, 2855, 21301, 21300, 463, </team_members_id><team_members_names><![CDATA[Zoran Kokan, Berislav Perić, Zoran Glasovac, Dražen Vikić-Topić, Saša Opačak, Natalija Pantalon Juraj, Goran Miletić, ]]></team_members_names><keywords_hr><![CDATA[aminokiseline, asimetrična kataliza, bioanorganska kemija, koordinacijska kemija, supramolekulska kemija]]></keywords_hr><keywords_en><![CDATA[Amino Acids, Asymmetric Catalysis, Bioinorganic Chemistry, Coordination Chemistry, Supramolecular Chemistry]]></keywords_en><summary_hr><![CDATA[Svrha ovog projekta je razvoj kiralnih katalizatora prijelaznih metala s posebnim naglaskom na inspiraciju iz prirode. Predložena je struktura beta-okreta kao ključno obilježje kiralnih katalizatora koji oponašaju umjetne enzime s minimalnom, ali fukcionalnom kiralnom vanjskom koordinacijskom sferom. Ovi minimalni umjetni enzimi mogli bi naći primjenu u asimetričnoj sintezi lijekova ili međuprodukata lijekova proizvedenih u farmaceutskoj industriji.U asimetričnoj katalizi opće je prihvaćeno da kiralna informacija mora biti prisutna što bliže koordinacijskoj sferi katalitičkog metala. Mi propitujemo ovo važno načelo i koristimo katalitički metalni centar koji je samo prokiralan. Kiralna informacija se prenosi &#39;&#39;posrednom indukcijom&#39;&#39; putem vodikovih veza udaljenih aminokiselina koje predstavljaju vanjsku koordinacijsku sferu. Preliminarni rezultati snažno podržavaju izvodljivost projekta, jer pokazuju da jednostavni biokonjugati monodentatnih trifenilfosfanskih liganada mogu tvoriti supramolekulske L2M komplekse s Rh(I) koji selektivno kataliziraju modelnu reakciju asimetričnog hidrogeniranja sa značajnim utjecajem redosljeda udaljenih aminokiselina na selektivnost [Kirin and Kokan, RSC Adv. 2012, Eur. J. Org. Chem. 2013 i Organometallics 2014; e.v. do 84 %].U okviru ovog projekta, predloženo je značajno proširenje uključujući (i) uporebu novih biokonjugata liganada s fosfornim ili dušikovim donorskim atomom, (i) uporeba novih supstrata te (iii) upotreba drugih prijelaznih metala za različite asimetrične reakcije, kao što su Ru(II)-katalizirano hidrogeniranje, Pd(II)-katalizirana alkilacija i Ln(III)-katalizirana sililcijanacija.]]></summary_hr><summary_en><![CDATA[This project aims at the development of chiral transition metal catalysts with particular emphasis on inspiration taken from nature. A beta-turn structure is proposed as key feature of chiral catalysts that resemble artificial enzymes with a minimal but functional outer-coordination sphere. These minimal artificial enzymes could find applications in asymmetric synthesis of drugs or drug intermediates produced by pharmaceutical industry.In asymmetric catalysis it is well established that the chiral information should be incorporated as close as possible to the coordination sphere of the catalytic metal. We challenge this important principle and use a catalytic metal center that is only prochiral. The chirality is transmitted by &#39;&#39;backdoor induction&#39;&#39; via hydrogen bonding of distant pendant amino acids that represent the outer-coordination sphere. Preliminary results provide a proof of concept and strongly indicate that simple amino acid bioconjugates of monodentate triphenylphosphane ligands can form supramolecular L2M complexes with Rh(I) that selectively catalyze a model asymmetric hydrogenation reaction with major impact of the distant amino acid sequence on selectivity [Kirin and Kokan, RSC Adv. 2012, Eur. J. Org. Chem. 2013 and Organometallics 2014; ee’s up to 84 %].Within this project, a significant extension is proposed including (i) the use of new ligand bioconjugates with phosphorous or nitrogen donor atoms, (ii) the use of new substrates and (iii) the use of other transition metals for different asymmetric reactions, namely Ru(II)-catalyzed hydrogenation, Pd(II)-catalyzed alkylation and Ln(III) catalyzed silylcyanation.]]></summary_en></project><project>
<id>3090</id><title_hr><![CDATA[Optimizacija parametarski ovisnih mehaničkih sustava]]></title_hr><title_en><![CDATA[Optimization of parameter dependent mechanical systems]]></title_en><user_id>935</user_id><user_firstLast_name>Ninoslav Truhar</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2014-09</proposal_call><code>IP-2014-09-9540</code><acronim><![CDATA[OptPDMechSys]]></acronim><duration>01.07.2015 - 30.06.2019</duration><status>Završio</status><financ_value>111.149,14 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Matematika, </scie_field_hr><scie_field_en>Mathematics, </scie_field_en><institution_hr><![CDATA[Sveučilište Josipa Jurja Strossmayera u Osijeku, Fakultet primijenjene matematike i informatike]]></institution_hr><institution_en><![CDATA[Josip Juraj Strossmayer University of Osijek, School of Applied Mathematics and Informatics]]></institution_en><team_members_id>838, 4088, 4113, 883, 844, 4596, 25434, </team_members_id><team_members_names><![CDATA[Ivana Kuzmanović, Nevena Jakovčević Stor, Ivan Slapničar, Suzana Miodragović, Zoran Tomljanović, Peter Benner, Istkhar Ali, ]]></team_members_names><keywords_hr><![CDATA[veliki parametarski ovisni mehanički sustavi, nelinearni svojstveni problemi, optimizacija prigušenja, optimalno upravljanje, matrične jednadžbe]]></keywords_hr><keywords_en><![CDATA[ large-scaled parameter dependent mechanical systems,  nonlinear eigenvalue problem, damping optimization, optimal control, matrix equations]]></keywords_en><summary_hr><![CDATA[Ovaj je projekt posvećen proučavanju mehaničkih sustava drugog reda opisnih sustavom običnih diferencijalnih jednadžbi čije su matrice velikih dimenzija, ovisne o jednom ili više realnih parametara. Glavnina istraživanja bit će usmjerena na: optimizaciju aktivnog i pasivnog prigušenja, optimalno upravljanje parametarski ovisnim mehaničkim sustavima sa i bez vanjske sile; opisivanje svojstava svojstvenih vrijednosti i svojstvenih vektora parametarski ovisnog pripadnog kvadratnog odnosno nelinearnog problema.Za problem optimizacije aktivnog i pasivnog prigušenja mehaničkih sustava sa i bez vanjske sile, razvit ćemo opći teorijski okvir, i konstruirati adekvatne numeričke algoritme. Ta će teorijska razmatranja biti vezana za optimizaciju raznih parametara prigušenja vezanih uz nekoliko različitih optimizacijskih kriterija. Nadalje, u okviru navedenih problema rješavat ćemo mnoge numerički zahtjevne probleme: problem mješovite cjelobrojne nelinearne optimizacije, efikasno rješavanje velikih matričnih jednadžbi (Lyapunov, Sylvester, Riccati), poboljšanje optimizacijskih algoritama redukcijom modela. Takodjer ćemo razmatrati kako teorijski tako i numerički aspekt problema optimizacije semi-aktivnog prigušenja te optimalnog upravljanja s aspekta različitih kriterija.U okviru problema opisivanja ponašanja svojstvenih vrijednosti i svojstvenih vektora parametarski ovisnog kvadratnog problema, razvit ćemo perturbacijsku teoriju za pripadni kvadratni problem, pri čemu ćemo posebno proučavati slučaj kad je pripadni linearizirani par  dijagonalizabilan, a posebno kada je par definitan. Za oba slučaja razvit ćemo pripadne perturbacijske teorije apsolutnog i relativnog tipa.Navedeni problemi su povezani tako da će nam uvid u ponašanje svojsvenih vrijednosti i pripadnih vektora omogućiti bolje razumjevanje djelovanja prigušenja ili drugih dijelova mehaničkih sustava i obratno. ]]></summary_hr><summary_en><![CDATA[This project is devoted to the second order mechanical systems described by a system of differential equations, whose coefficient matrices are large-scaled and dependent on one or more real parameters.The majority of the research within this project will be focused on: optimization of active and passive damping and optimal control of parameter dependent mechanical systems with and without external force; describing the properties of eigenvalues and eigenvectors of the corresponding parameter-dependent quadratic or nonlinear problem.Within the problem of active and passive damping optimization and optimal control of parameter dependent mechanical systems with and without external force, we will develop a general theoretical framework. These theoretical considerations will be related to the optimization of various damping parameters with respect to a several different optimization criteria. Furthermore, within the stated objectives we will solve many numerical demanding problems: mixed-integer nonlinear optimization problem, efficiently solving of large matrix equations (Lyapunov, Sylvester, Riccati), improving the optimization algorithms by dimension reduction. We will also consider theoretical and numerical aspects of optimization of semi-active damping problem and optimal control based on various criteria.Within the problem of describing the behavior of eigenvalues and eigenvectors of the parameter-dependent nonlinear eigenvalue problems, we will develop perturbation theory for the corresponding quadratic problem separately for cases when the corresponding linearized  pair is diagonalizable or definite. For both cases we will develop perturbation theory of absolute and relative type for the eigenvalues and associated eigenvectors i.e. subspaces.The all mentioned problems are closely related, thus the insight into the behavior of eigenvalues and corresponding eigenvectors will allow better understanding of the behavior of mechanical systems and vice versa.]]></summary_en></project><project>
<id>3101</id><title_hr><![CDATA[Dizajn i sinteza novih dušikovih heterocikličkih fluorofora i fluorescentnih nanomaterijala kao kemijskih senzora za pH i metalne ione]]></title_hr><title_en><![CDATA[Design and Synthesis of Novel Nitrogen-Containing Heterocyclic Fluorophores and Fluorescent Nanomaterials for pH and Metal-Ion Sensing]]></title_en><user_id>227</user_id><user_firstLast_name>Robert Vianello</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2014-09</proposal_call><code>IP-2014-09-3386</code><acronim><![CDATA[iNFiNiTE–SENS]]></acronim><duration>01.06.2015 - 31.05.2019</duration><status>Završio</status><financ_value>128.475,68 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, </scie_field_hr><scie_field_en>Chemistry, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>854, 3397, 3211, 12962, 2914, 4801, 13134, 2847, 2768, 2769, 4295, </team_members_id><team_members_names><![CDATA[Darko Babić, Ines Despotović, Nena Radić, Ivana Steinberg, Marijana Hranjec, Svjetlana Krištafor, Lidija  Furač, Irena Sović, Maja Aleksić, Nataša Perin, Ema Horak, ]]></team_members_names><keywords_hr><![CDATA[senzori za pH i metalne ione, fluorescentni kemosenzori, fluorofori dobiveni klik-kemijom, sol-gel nanomaterijali, dušikovi heterocikli]]></keywords_hr><keywords_en><![CDATA[metal-ion and pH sensors, fluorescent chemosensors, click-chemistry derived fluorophores, sol-gel nanomaterials, nitrogen heterocycles]]></keywords_en><summary_hr><![CDATA[Ovaj projekt okuplja interdisciplinarni tim znanstvenika s ciljem priprave novih i učinkovitih funkcionalnih materijala za primjenu u području senzora za pH i metalne ione.  Kroz sinergiju u sintetičkim, spektroskopskim i računalnim tehnikama, usmjerit ćemo naša istraživanja na dizajniranje i karakterizaciju čitavog kataloga spojeva sa željenim analitičkim i kemijskim karakteristikama. Eksperimentalni dio posla uključivat će tradicionalne i &#39;&#39;click&#39;&#39;-kemijske strategije za sintezu niza različitih derivata benzimidazola, benzotiazola, 1,2,3-triazola i kumarina, koji će se ugraditi u brojne organske, anorganske i hibridne polimerne matrice u svrhu dobivanja osjetljivih tankih filmova ili polimernih nanočestica. Nakog toga, uz pomoć UV/Vis i fluorescentne spektroskopije, dobiveni materijali bit će ispitani na sposobnost stvaranja kompleksa s metalnim kationima u otopini i čvrstoj fazi te mogućnost formiranja kemijskih senzora. Izbor metalnih analita bit će potaknut njihovom biološkom važnošću ili prisutnošću u okolišu, a uključivat će katione poput Zn2+, Cu2+, Mn2+, Hg2+, Ag+, Cd2+, Fe2+/Fe3+ te Pb2+. Sve faze eksperimentalnog rada nadopunit će se računalnom podrškom za pomoć u tumačenju dobivenih rezultata. To će uključivati izračun konformacijskih, tautomernih i pKa svojstava proučavanih spojeva, predviđanje načina i slobodnih energija vezanja metala te modeliranje promjena u odgovarajućim UV/Vis apsorpcijskim i emisijskim spektrima potaknutim vezanjem metala ili promjenom pH uvjeta otopine. Osim toga, simulacije će biti proširene i razmatranjem različito supstituiranih derivata priređenih organskih molekula kako bi se fino podesila željena svojsta te tako pomoglo ciljanom odabiru budućih koraka u istraživanjima. Sveukupno gledano, predloženi projekt pozicionira ovaj tim za iskorak u području kemijskih senzora uz mogućnost širokog raspona industrijskih aplikacija – od biomedicine do znanosti o okolišu.]]></summary_hr><summary_en><![CDATA[This project brings together an interdisciplinary team of researchers with the aim to prepare novel and efficient functional materials to be used for metal-ion and pH sensing applications. Through a synergy in the synthetic, spectroscopic and computational techniques, we plan to focus our investigations on designing and characterizing a whole catalogue of compounds with desirable analytical and chemical features. Experimental work will involve traditional and &#39;&#39;click-chemistry&#39;&#39; strategies for the synthesis of a number of diverse benzimidazole, benzothiazole, 1,2,3-triazole, and coumarin derivatives, which will be incorporated into a range of organic, inorganic and hybrid polymeric matrices to form sensitive thin films or polymeric nanoparticles. Subsequently, through the UV/Vis and fluorescent spectroscopies, these will be assessed for their abilities to form both solution- and solid-phase complexes with metal cations in order to produce usable chemosensors. The choice of the metal analytes will be prompted by their biological significance or their presence in the environment, comprising cations such as Zn2+, Cu2+, Mn2+, Hg2+, Ag+, Cd2+, Fe2+/Fe3+, and Pb2+. All phases of experimental work will be supplemented with the computational support to aid in the interpretation of results. This will include calculating the conformational, tautomeric and pKa features of investigated systems, predicting the modes and free-energies of metal binding, and modeling the changes in the matching UV-Vis absorption and emission spectra induced by the metal complexation and solution pH variations. In addition, computations will be advanced by considering substituted derivatives of the prepared organic frameworks in order to fine-tune the preferred properties, thus helping in the guided selection of future directions. Overall, the presented research is intended to pose this team for the advancements in the field of chemosensors with the promise of a wide range of industrial applications.]]></summary_en></project><project>
<id>3103</id><title_hr><![CDATA[Sinteza i ciljana primjena metalnih nanočestica]]></title_hr><title_en><![CDATA[Synthesis and Targeted Application of Metallic Nanoparticles]]></title_en><user_id>158</user_id><user_firstLast_name>Iva Rezić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2014-09</proposal_call><code>UIP-2014-09-1534</code><acronim><![CDATA[STARS]]></acronim><duration>01.09.2015 - 31.12.2018</duration><status>Prekinut</status><financ_value>112.411,57 eur</financ_value><scie_area_hr>Tehničke znanosti, Biotehničke znanosti, Prirodne znanosti, </scie_area_hr><scie_area_en>Technological sciences, Biotechnical sciences, Natural sciences, </scie_area_en><scie_field_hr>Kemijsko inženjerstvo, Kemija, Tekstilna tehnologija, Biotehnologija, </scie_field_hr><scie_field_en>Chemical engineering, Chemistry, Textile technology, Biotechnology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Tekstilno-tehnološki fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Textile Technology]]></institution_en><team_members_id>351, 2958, 12569, 12361, 602, 517, 1048, </team_members_id><team_members_names><![CDATA[Ana Vrsalović Presečki, Maja Somogyi Škoc, Martina Marchetti-Deschmann, Kristina Šimić, Tatjana Haramina, DAMIR OROS, Roland Ludwig, ]]></team_members_names><keywords_hr><![CDATA[nanočestice, enzimi, polimeri, sol-gel proces, GEMMA, PDMA, GF-AAS, LC-MS/MS]]></keywords_hr><keywords_en><![CDATA[nanoparticles, enzymes, polymers, sol-gel process, GEMMA, PDMA, GF-AAS, LC-MS/MS]]></keywords_en><summary_hr><![CDATA[Glavni cilj projekta uspostava je interdisciplinarne međunarodne istraživačke skupine koja će sintetizirati nove metalne nanočestice pomoću ekološki prihvatljivih enzimski kataliziranih reakcija, te ih zatim nanositi na razne polimerne materijale. Metalne nanočestice imaju odlična nova elektronička, optička, magnetska, medicinska, katalitička i mehanička svojstva zahvaljujući specifičnoj površini koja izrazito ovisi o njihovoj veličini, strukturi i obliku. Predviđa se kako će globalna potražnja za nanočesticama metala i metalnih oksida porasti sa 270 tona u 2012. godini na 1700 tona u 2020. godini. Mi ćemo izolirati i primijeniti pet različitih enzima kako bi sintetizirali metalne nanočestice, odredili kinetiku i mehanizme provedenih reakcija, te zatim karakterizirali produkte reakcije uporabom “beyond-state-of-the-art“ instrumentalnih metoda (GEMMA, PDMA, MALDI-TOF-MS/MS i drugih tehnika). Provedba ovog projekta pomoći će pri osnivanju međunarodne istraživačke grupe koja će obuhvatiti teme iz područja nanotehnologije,  znanosti o materijalima, analitike i bioanalitike, a također će povećati istraživački potencijal mladih istraživača nabavkom znanstvene opreme koja je nužna za provođenje istraživanja vezanog uz sintezu i ciljanu primjenu metalnih nanočestica. Nakon nanošenja pojedinih ciljanih nanočestica na polimere, planiramo razviti nove materijale s namjenskom primjenom u ambalaži prehrambenih proizvoda i geotekstilija. Stoga će ovaj projekt podržati razvoj hrvatske prehrambene i tekstilne industrije. Nadalje, projekt će potaknuti interdisciplinarno istraživanje te omogućiti transfer znanja među istraživačkim grupama u Republici Hrvatskoj, kao i pružiti mogućnost transfera znanja studentima poslijedoktorskih, doktorskih i diplomskih studija koji će biti uključeni u projekt. Valja napomenuti kako će ovaj projekt ojačati i suradnju sa znanstvenicima europskih sveučilišta, te time poduprijeti integraciju hrvatskih znanstvenika u europski istraživački okvir.]]></summary_hr><summary_en><![CDATA[The main objective of this project is to establish international interdisciplinary research group that will synthesize new metal nanoparticles by environmental friendly enzymatic reactions and apply them on different polymer materials. Metal nanoparticles have novel electronic, optical, magnetic, medical, catalytic and mechanical properties owing to their high surface to volume ratio and the quantum size effect, which depend greatly on their size, structure and shape. Therefore a conservative estimation of the world market predicts the global consumption of metal oxide nanoparticles to rise from 270 tons in 2012 to 1700 tons by 2020. We will isolate and use five different enzymes to synthesize metallic nanoparticles, reveal the kinetics and mechanism of reactions, and characterize the products by using “beyond-state-of-the-art” instrumental methods (such as GEMMA, PDMA and MALDI-TOF-MS/MS). Implementation of this project will help establishing new interdisciplinary research group targeting problems in the fields of nanotechnology, material science and bio/analytical chemistry, as well as enhance the independent research leadership of the principal investigator by installing the scientific infrastructure necessary for research on the synthesis and targeted application of metal nanoparticles. By deposition of targeted nanoparticles on polymers, we will create new materials foreseen as food packaging materials and geotextiles. This will support the development of the Croatia’s food and textile industries. Moreover, the project will initiate interdisciplinary research with the transfer of knowledge among research groups, as well as provide the opportunity to transfer knowledge to postdoctoral, doctoral and diploma students working on this project. In addition, this project will strengthen international collaborations with scientists from other European universities, and by this support the integration of the Croatian science within the European research framework. ]]></summary_en></project><project>
<id>3108</id><title_hr><![CDATA[Uporaba metoda i otvorenih tehnologija dubinske analize podataka za unaprijeđenje infrastrukture elektroničkog učenja]]></title_hr><title_en><![CDATA[Leveraging data mining methods  and open technologies for enhancement of the e-learning infrastructure]]></title_en><user_id>3529</user_id><user_firstLast_name>Damir Pintar</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2014-09</proposal_call><code>UIP-2014-09-2051</code><acronim><![CDATA[eduMINE]]></acronim><duration>01.10.2015 - 31.12.2018</duration><status>Završio</status><financ_value>57.965,36 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Računarstvo, </scie_field_hr><scie_field_en>Computer sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id>3645, 3641, 5132, 3643, 7042, 17798, </team_members_id><team_members_names><![CDATA[Mihaela Vranić, Luka Humski, Zoran Skočir, Frano Škopljanac-Mačina, Boris Vrdoljak, Marina Ptiček, ]]></team_members_names><keywords_hr><![CDATA[rudarenje podataka, elektroničko učenje, analiza podataka, konceptualne mape,  uslužna orijentirast, modeliranje ponašanja]]></keywords_hr><keywords_en><![CDATA[educational data mining,  e-learning, data analysis, , concept maps, service-oriented, behavior modelling]]></keywords_en><summary_hr><![CDATA[Informacijski sustavi u školama i sveučilištima stvaraju ogromne količine podataka koji, nakon svoje incijalne uporabe, se najčešće arhiviraju te koriste isključivo u agregiranom obliku za potrebe sažetog izvještavanja. Naš tim predlaže stvaranje rješenja eduMINE, u kojem bi se kroz primjenu metoda rudarenja podataka i pripadnih algoritama uz pomoć navedenih podataka otkrili potencijalno interesantni uzorci i nove informacije, prateći najnovija znanstvena dostignuća iz znanstvenog polja EDM (Educational Data Mining). Rezultati ispita, prilagođene konceptualne mape i ostali podaci služili bi kao ulaz u proces rudarenja. Rezultati metoda bili bi integrirani u trenutni sustav potpore elektroničkom učenju s namjrom da pruži korisne povratne informacije nastavnom osoblju, kako vezano uz stvaranje i prilagodbu nastavnih materijala tako i kroz stvaranje balansiranih, objektivnih ispita. Rezultati rudarenja također bi trebali pomoći u ranoj identifikaciji studenata koji su u opasnosti pada kolegija.Bitno je naglastiti da svi članovi ovog projekta imaju široko iskustvo sa metodama analize podataka te da su objavili niz članaka vezanih uz algoritme i mjere korištene u polju rudarenja podataka. Dodatno, tim ima višegodišnje iskustvo u sveučilišnoj edukaciji, uglavnom na velikim predmetima prve i druge godine sveučilišnog obrazovanja koje godišnje pohađa preko 600 studenata. Smatramo da uz dovoljno vremena i resursa možemo ponuditi rješenje koje će dodatno povisiti kvalitetu obrazovanja i biti primjenjivi ne samo u okruženju u kojem djelujemo već u bilo kojoj sličnoj obrazovnoj okolini.]]></summary_hr><summary_en><![CDATA[Information systems in schools and universities generate large amounts of data. This data, after its initial usage, is most commonly archived and used only in aggregate forms for condensed reports. We propose a pilot project called eduMINE, in which we will apply data mining methods and algorithms on this data to discover potentially interesting patterns and other information hidden within, following recent reasearch accomplishments from the field of EDM (Educational Data Mining). Test scores, customized concept maps and other available data will serve as input for the data mining process. Results of these methods will then be integrated with the existing e-learning support information system with the intention to provide a useful feedback to the lecturers, both regarding the course lectures generation and adaptation as well as generation of well balanced and objective tests. Results should also aim to help with early identification of students who are in danger of failing a course.It is important to emphasize that all team members of this research proposal have extensive experience in methods of data analysis and have developed and published research papers describing new algorithms and measures used for certain data mining approaches. Furthermore, the team has plenty of direct experience in education, most of it concerning large first and second-year college-level courses taken by over 600 students yearly. We are confident that given enough time and resources we can offer solutions which would result in further enhance the quality of education and be applicable not just in the specific domain we are directly involved in, but in any similar education environment.]]></summary_en></project><project>
<id>3121</id><title_hr><![CDATA[Hrvatsko longitudinalno istraživanje dobrobiti]]></title_hr><title_en><![CDATA[Croatian Longitudinal Study on Well-Being]]></title_en><user_id>67</user_id><user_firstLast_name>Ljiljana Kaliterna Lipovčan</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2014-09</proposal_call><code>IP-2014-09-4398</code><acronim><![CDATA[CRO-WELL]]></acronim><duration>01.10.2015 - 30.09.2019</duration><status>Završio</status><financ_value>60.003,98 eur</financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Psihologija, </scie_field_hr><scie_field_en>Psychology, </scie_field_en><institution_hr><![CDATA[Institut društvenih znanosti Ivo Pilar]]></institution_hr><institution_en><![CDATA[Institute of Social Sciences Ivo Pilar in Zagreb]]></institution_en><team_members_id>133, 5219, 3880, 2727, 190, 6242, 5522, 1255, 23199, </team_members_id><team_members_names><![CDATA[Andreja Brajša-Žganec, Tihana Brkljačić, Renata Franc, Ines Sučić, Ivan Balabanić, Maja  Tadić, Renata Glavak Tkalić, Zvjezdana Prizmić-Larsen, Lana Lučić, ]]></team_members_names><keywords_hr><![CDATA[dobrobit, životni događaji, regulacija emocija, ličnost, longitudinalno istraživanje]]></keywords_hr><keywords_en><![CDATA[well-being, life events, affect regulation, personality, longitudinal study]]></keywords_en><summary_hr><![CDATA[Namjera nam je pokrenuti on-line longitudinalno istraživanje dobrobiti. Ovaj projekt ima dva cilja. Prvi cilj je provjeriti stupanj u kojem se dobrobit mijenja tijekom vremena i jesu li obrasci tih promjena različiti za ljudie različitih osobina. Drugi cilj je ispitati može li se dobrobit smatrati ne samo pokazateljem dobrog života, nego i nužnim dijelom povoljnih ishoda i pozitivnih životnih događaja, kao što je predloženo u teoriji proširenja i izgradnje pozitivnih emocija. Mi tvrdimo da visoke razine dobrobiti omogućavaju stvaranje kasnijih povoljnih životnih događaja i uvjeta za učinkovite strategije regulacije emocija. Tijekom razdoblja od četiri godine planiramo provesti on-line panel istraživanje u četiri vala. U istraživanju će biti korišten uzorak odraslih internet korisnika u Hrvatskoj. Bit će prikupljeni podaci o socio-demografskim varijablama, osobinama ličnosti, različitim sastavnicima dobrobiti, strategijama regulacije emocija i životnim događajima. U pilot testiranju bit će provedene fokus grupe u svrhu razvoja instrumenata. Kako bi privukli što je moguće više sudionika u istraživanje i smanjili osipanje tijekom provedbe uzastopnih valova istraživanja, puno će truda biti uloženo u promociju i oglašavanje projekta, kao i u informiranje i motiviranje sudionika da nastave sa sudjelovanjem u istraživanju. Praćenjem ljudi kroz duži period moći ćemo bolje objasniti povezanost između dobrobiti i životnih ishoda, kao i promjena u dobrobiti.]]></summary_hr><summary_en><![CDATA[We intend to launch on-line longitudinal research on well-being. The goal of the project is twofold. First, to examine the degree to which well-being fluctuates over time and whether patterns of well-being fluctuations are different for different types of people. Second, we aim to examine whether well-being can be considered not only as an indicator of good life, but also as a precondition of  positive outcomes and favourable life events, as proposed in the broaden-and-build theory of positive emotions. We posit that high levels of well-being enable the creation of later favourable life events and conditions by effective affect regulation strategies. During the four year project period, we plan to conduct on-line four-wave panel survey. Study sample will consist of adult internet users in Croatia. Through the survey, data on socio-demographic variables, personality traits, different components of well-being, affect regulation strategies and life events will be collected. Focus groups will be used as pilot tests to develop instruments. In order to recruit as many respondents as possible and to minimize attrition over the course of the consecutive waves lots of effort will be put into project promotion and advertising, as well as into informing and motivating participants to continue with the research. By following people through longer periods of time we would be able to better explain the relationships between well-being and life outcomes, as well as fluctuations in well-being.]]></summary_en></project><project>
<id>3125</id><title_hr><![CDATA[Univerzalne osobine sustava hladnih bozonskih i fermionskih atoma]]></title_hr><title_en><![CDATA[Universal properties of cold atomic Bose and Fermi systems]]></title_en><user_id>875</user_id><user_firstLast_name>Leandra Vranjes Markic</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2014-09</proposal_call><code>IP-2014-09-2452</code><acronim><![CDATA[UniCold]]></acronim><duration>15.06.2015 - 14.03.2019</duration><status>Završio</status><financ_value>79.036,43 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, </scie_field_hr><scie_field_en>Physics, </scie_field_en><institution_hr><![CDATA[Sveučilište u Splitu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Split, Faculty of Science]]></institution_en><team_members_id>4442, 6261, 4840, 6341, 20888, 18947, 18948, </team_members_id><team_members_names><![CDATA[Petar Stipanović, Robert Zillich, Jordi Boronat Medico, Henry  Glyde, Andrii Gudyma, Krešimir Dželalija, Viktor Cikojević, ]]></team_members_names><keywords_hr><![CDATA[ultrahladni plinovi, kvantni Monte Carlo, univerzalnost, nered, BEC, suprafluidnost, spin-orbit vezanje, kvantna halo stanja]]></keywords_hr><keywords_en><![CDATA[ultracold gases, Quantum Monte Carlo, universality, disorder, BEC, superfluid, spin-orbit coupling, quantum halo state]]></keywords_en><summary_hr><![CDATA[Ultrahladni plinovi nude besprimjerne mogućnosti proučavanja jako koreliranih sustava  i razmatranje izazova u različitim područjima fizike.  Pogodni su zbog podesivosti jačine  interakcija i mogućnosti kontroliranja i  istraživanja utjecaja dimenzionalnosti, neredai kvantne statistike. Omogućavaju eksperimentalno ostvarenje kako tradicionalnih modela fizike kondenzirane materije tako i novih sustava kao što su spin-orbit vezani (SOC) bozoni.Posebno su zanimljive njihove univerzalne osobine, koje omogućavaju uspostavljanje veza između fenomena na različitim skalama energije i duljine. Rezonantni režim s duljinom raspršenja jednakom nulipredstavlja univerzalnu jako interagirajuću unitarnu granicu, gdje su potrebna točna teorijska predviđanja koja uključuju efekte iznad teorije srednjeg polja. Kvantnim Monte Carlo(QMC) metodama moguće je točno riješiti višečestičnu Schrodingerovu jednadžbu za atome, molekule, tekućine, krutine i različite modele. U projektu ćemo dalje razviti metode te ih primijeniti na probleme sustava hladnih bozonskih i fermionskih atoma, s ciljem karakterizacije njihovih univerzalnih osobina. Prvo, proučit ćemo sustave malog broja čestica, fokusirajući se na realistična molekularna kvantna halo stanja, kao što su klasteri helija i alkalijskih atoma. Cilj je utvrditi mogu li se univerzalne relacije skaliranja  između energije i veličine sustava, već utvrđene na primjeru trimera, proširiti na sustave većeg broja čestica, što je važno  i za halo stanja u nuklearnoj fizici. Nadalje će se proučiti utjecaj nereda i dimenzionalnosti na univerzalne osobine bozonskih i bozonsko ferminskih mješavina u zamkama. Posebno zanimljiv je prijelaz između suprafluida i izolatora te lokalizacija suprafluidnosti i Bose-Einsteinove kondenzacije. Naposljetku, QMC metode ćemo dodatno razviti tako da uzimaju u obzir i spinove čestica, što će omogućiti proučavanje univerzalnosti i novih faza SOC plinova.                                                                                                                  ]]></summary_hr><summary_en><![CDATA[Ultracold gases provide unprecedented possibilities to study strongly correlated systems and address challenges indifferent fields of physics. The advantages they provide aretunability of interactions, possibility to control and exploredimensionality effects, disorder and quantum statistics. Theyallow the experimental realisation and study of both traditionalmodels from condensed matter physics and novel systems suchas spin-orbit coupled (SOC) bosons. Especially interesting are their universal properties, which enable establishment of connections betweenphenomena at different energy and length scales. The resonant regimeof zero-scattering length provides a universal strongly interacting unitary limit, where accurate theoretical predictions beyond mean field are necessary.  Quantum Monte Carlo (QMC) methods are able to accurately solve many-bodySchrodinger equation of atoms, molecules, liquids, solidsand different model systems. In the project we&#39;ll further developthe methods and apply them to problems in the field of coldBose and Fermi atoms, with the goal to characterize their universal properties. First, we&#39;ll study few-body systems,focusing on realistic molecular quantum halo states, such ashelium-alkali clusters. The goal is to establish whether universal scaling relations between energy and size, already established for trimers, can be established for clusters with more particles. This would provide benchmarkfor halo states in nuclear physics. Next, the effect of disorder and dimensionality on universal properties of trapped Bose-Bose and Bose-Fermi systems will be studied.Especially interesting is the superfluid-insulator transition and localization ofsuperfluidity and Bose-Einstein condensation. Finally, QMCmethods will be further developed so that spin degree offreedom is explicitly accounted for, which will allow study ofuniversality and novel phases of SOC gases.                                                                      ]]></summary_en></project><project>
<id>3128</id><title_hr><![CDATA[Genomski i glikanski biomarkeri PTSP-a]]></title_hr><title_en><![CDATA[Genomic and glycomic biomarkers for PTSD]]></title_en><user_id>1306</user_id><user_firstLast_name>Nela Pivac</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2014-09</proposal_call><code>IP-2014-09-4289</code><acronim><![CDATA[GlycoGenePTSD]]></acronim><duration>01.10.2015 - 30.09.2019</duration><status>Završio</status><financ_value>132.722,81 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, Kliničke medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, Clinical sciences, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>1059, 1022, 1023, 4477, 4478, </team_members_id><team_members_names><![CDATA[Dubravka Švob Štrac, Gordana Nedić Erjavec, Matea Nikolac Perković, Suzana Uzun, Oliver Kozumplik, ]]></team_members_names><keywords_hr><![CDATA[PTSP, N-glikani, epigenetika, GWAS, genetika]]></keywords_hr><keywords_en><![CDATA[PTSD, N-glycans, epigenetics, GWAS, genetics]]></keywords_en><summary_hr><![CDATA[Napredak u razumijevanju glikanskih funkcija i struktura može ponuditi nove biomarkere PTSP-a. Rezultati GWAS studija kombiniranih s metodama visoke djelotvornosti, kao što su analize fluorescentno obilježenih glikana, pokazali su da su geni B3GAT1, SLC9A9, MGA5, FUT8, FUT3/FUT6 i HNF1A povezani s glikozilacijom u zdravih osoba iz Hrvatske. Određivanje plazmatskih i IgG N-glikana u PTSP-u, dodatno korigiranih za mogući genetski i epigenetski utjecaj, poboljšat će naše razumijevanje biološke osnove PTSP-a. Cilj predloženog projekta je istražiti povezanost između genetskih, epigenetskih i glikomskih mehanizama odgovornih za otpornost ili ranjivost na razvoj PTSP-a nakon izlaganja traumatskom iskustvu/iskustvima.Specifični ciljevi projekta su:1) određivanje N-glikana u plazmi i IgG-u bolesnika s PTSP-om i odgovarajućih kontrolnih ispitanika;2) potvrda specifičnih polimorfizama odabranih gena koji reguliraju glikozilaciju proteina, određenih putem GWAS studija, u bolesnika s PTSP-om i odgovarajućih kontrolnih ispitanika;3) procjena utjecaja epigenetske regulacije i ekspresije gena HNF1A na glikozilaciju proteina u bolesnika s PTSP-om i odgovarajućih kontrolnih ispitanika.Ovakav pristup će ponuditi integraciju i razumijevanje multidimenzionalnih baza podataka i identificirati nove biomarkere PTSP-a, kao i nove mete i nove strategije u prevenciji razvoja PTSP-a nakon izlaganja traumi ili u terapijskoj intervenciji u PTSP-u.]]></summary_hr><summary_en><![CDATA[The advances in understanding of glycans’ function and structure might offer new biomarkers of PTSD. The results from GWAS, combined with high throughput analysis of fluorescently labelled glycans, suggest B3GAT1, SLC9A9, MGA5, FUT8, FUT3/FUT6 and HNF1A genes to be associated with glycosylation in healthy individuals from Croatia. Determination of N-glycans associated with PTSD in plasma and from IgG, additionally corrected for a possible genetic and epigenetic influence, will improve our understanding of the biological underpinnings of PTSD. The proposed project aims to provide an association between genetic, epigenetic and glycomic mechanisms responsible for the resilience or vulnerability to develop PTSD after exposure to a traumatic event(s).The specific aims of the project are:1) determination of plasma and IgG N-glycans in patients with PTSD and in matched control subjects;2) confirmation of the polymorphisms in the specific selected genes which regulate protein glycosilation, determined by GWAS, in patients with PTSD and in matched control subjects; 3) evaluation of the influence of epigenetic regulation and expression of the HNF1A gene on protein glycosylation in patients with PTSD and in matched control subjects.This approach will offer integration and understanding of the multidimensional dataset and identify novel biomarkers of PTSD, as well as new targets and novel strategies to prevent development of PTSD after exposure to a trauma, or for therapeutic intervention in PTSD.]]></summary_en></project><project>
<id>3137</id><title_hr><![CDATA[Adipocitokinima modulirana disfunkcija endotela u podlozi mikrovaskularnih komplikacija šećerne bolesti tipa 1 i tipa 2]]></title_hr><title_en><![CDATA[Relationship between endothelial dysfunction driven by adipocitokines and the development and progression of microvascular complications in patients with type 1 and type 2 diabetes]]></title_en><user_id>12770</user_id><user_firstLast_name>Lea Smirčić Duvnjak</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2014-09</proposal_call><code>IP-2014-09-7459</code><acronim><![CDATA[ADIEDM]]></acronim><duration>16.12.2015 - 15.12.2019</duration><status>Prekinut</status><financ_value>81.677,62 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Kliničke medicinske znanosti, </scie_field_hr><scie_field_en>Clinical sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb School of Medicine]]></institution_en><team_members_id>12904, 12799, 12511, 1288, 13072, 12935, 13091, </team_members_id><team_members_names><![CDATA[Draško Pavlović, Sandra Vučković-Rebrina, Tomislav Bulum, Marijana Vučić Lovrenčić, Vladimir Vuksan, Martina Tomić, Vinko Vidjak, ]]></team_members_names><keywords_hr><![CDATA[adipocitokini, endotelna disfunkcija, mikrovaskularne komplikacije, šećerna bolest  tip 1, šećerna bolest tip 2]]></keywords_hr><keywords_en><![CDATA[adipocitokines, endothelial dysfunction, microvascular complications, diabetes mellitus type 1, diabetes mellitus type 2]]></keywords_en><summary_hr><![CDATA[Značaj šećerne bolesti počiva na pogubnom učinku mikro i makrovaskularnih komplikacija na morbiditet i mortalitet oboljelih. Stoga je njihova prevencija u središtu znanstvenog i stručnog interesa. Metabolički poremećaji u šećernoj bolesti: inzulinska rezistencija, hiperglikemija i dislipidemija uz oksidativni stres i upalu niskog stupnja doprinose endotelnoj disfunkciji i razvoju makrovaskularnih komplikacija. Novije spoznaje ukazuju na moguću ulogu adipocitokina visceralnog masnog tkiva u nastanku mikrovaskularnih komplikacija u šećernoj bolesti. Ispitivanja provedena na staničnim kulturama te eksperimentalnim životinjskim modelima ukazuju na povezanost  adiponektina, leptina, rezistina te dipeptidil peptidaze-4 (DPP4) sa  aktivnošću  endotelne sintetaze dušičnog oksida (eNOS). Pretpostavka ovog istraživanja je da niža plazmatska koncentracija adiponektina, a viša koncentracija leptina, rezistina i serumska aktivnost DPP4  pogoršanjem endotelne funkcije doprinose nastanku i progresiji mikrovaskularnih komplikacija šećerne bolesti.  Ovo prospektivno istraživanje uključit će 400 bolesnika s šećernom bolešću  tipa1 i tipa 2. Istražit će se učinak plazmatske koncentracije adiponektina, leptina, rezistina i serumske aktivnosti DPP4 na parametre endotelne disfunkcije: dušični monoksid (NO), von Wilebrandov faktor (vWF),  indeks reaktivne hiperemije i brzinu širenja pulsnog vala te razvoj i progresiju mikrovaskularnih komplikacija: retinopatije, nefropatije i neuropatije. Rezultati će doprinijeti razjašnjenju složene patogeneze mikrovaskularnih komplikacija u šećernoj bolesti. Moguća identifikacija novih biljega mikrovaskularnih komplikacija unaprijedit će njihovu dijagnozu u osnovnim tipovima šećerne bolesti uz posljedični razvoj individualiziranog pristupa njihovoj prevenciji i liječenju.]]></summary_hr><summary_en><![CDATA[Micro and macrovascular complications are the  leading cause of morbidity and mortality in diabetic patients.  During the last decades attention has been focused  on their early diagnosis and prevention. Diabetes related metabolic abnormalities:  insulin resistance, hyperglycemia and dyslipidemia along with oxidative stress and low- grade inflammation contribute to the development of endothelial dysfunction and macrovascular complications. Recent investigations indicate a potential role of adipocitokines originating from visceral adipose  tissue: adiponectin, leptin, resistin and dipepetidyl peptidase- 4  (DPP-4) activity in the development of microvascular complications in diabetes. The association of  these  adipocitokines with the activity of endothelial synthetase (eNOS) involved into the metabolism of nitric oxide (NO) was documented in animal and cell culture studies. We hypothesize that lower adiponectin and  higher leptin and resistin plasma concentration and DPP-4 activity are associated with the development and progression of diabetic microvascular complications by endothelial function impairment.Four hundred patients with type 1 and type 2 diabetes will be included in this prospective study.  The association between  adiponectin, leptin, resistin plasma concentration,  DPP-4 activity  and  endothelial markers: NO, von Wilebrand factor (vWF),  pulse wave velocity (PWV) and  reactive hyperemia index (RHI) on the development and progression of microvascular complications will be assessed.Our results will provide further insight into the complex pathophysiology of microvascular complications in diabetes. A possible identification of new markers of their development and progression will contribute to improved diagnosis followed by an individualized patients approach.]]></summary_en></project><project>
<id>3139</id><title_hr><![CDATA[Aktivni nadzor bjesnoće u šišmiša-bitan faktor za procjenu buduće prijetnje]]></title_hr><title_en><![CDATA[Active surveillance of rabies in bats - the essential factor for the assessment of the future threat]]></title_en><user_id>2533</user_id><user_firstLast_name>Tomislav Bedeković</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2014-09</proposal_call><code>UIP-2014-09-8513</code><acronim><![CDATA[BatsRabTrack]]></acronim><duration>01.04.2016 - 30.06.2019</duration><status>Završio</status><financ_value>114.531,61 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Veterinarska medicina, </scie_field_hr><scie_field_en>Veterinary medicine, </scie_field_en><institution_hr><![CDATA[Hrvatski veterinarski institut]]></institution_hr><institution_en><![CDATA[Croatian Veterinary Institute]]></institution_en><team_members_id>12561, 12614, 12606, 13064, 2543, 2564, </team_members_id><team_members_names><![CDATA[Florence Cliquet, Evelyne Picard-Meyer, Marine Wasniewski, Ivana Šimić, Nina Krešić, Ivana Lojkić, ]]></team_members_names><keywords_hr><![CDATA[šišmiši, bjesnoća, nadzor, prevalencija, procjena rizika ]]></keywords_hr><keywords_en><![CDATA[bats, rabies, surveillance, prevalence, risk assessment]]></keywords_en><summary_hr><![CDATA[Bjesnoća je jedna od najstarijih i najvažnijih zoonoza, s najvišom stopom smrtnosti od svih poznatih uzročnika zaraza, koja i dalje uzrokuje značajna obolijevanja i smrtnost kod ljudi. Rezervoari klasičnog virusa bjesnoće (RABV) genotipa 1 su vrste iz reda Carnivora te Chiroptera (šišmiši) u sjevernoj i južnoj Americi. U Europi su zastupljeni virusi šišmiša iz roda Lyssavirus, a nazivaju se Lyssavirusi europskog šišmiša (EBLV – European Bat Lyssavirus) tipa 1 i 2 (genotip 5 i 6). Ograničeni su na šišmiše kao domaćine, a poznato je da inficiraju ne samo svog primarnog domaćina nego i prenose infekciju na kopnene sisavce, uključujući domaće životinje, divljač i čovjeka. Infekcije šišmiša virusom EBLV u Europi potvrđene su uglavnom u Nizozemskoj, Njemačkoj, Danskoj i Poljskoj. Od 1977. godine prijavljena su četiri smrtna slučaja ljudi oboljelih od EBLV-a. Većina (>95%) virusnih izolata pripada EBLV tipu 1 i uglavnom je vezana uz šišmiše vrste kasni noćnjak (Eptesicus serotinus), dok su EBLV tip 2 vezani uz vrste roda Myotis. Aktivan nadzor šišmiša radi procjene prevalencije EBLV-a provodi se u zapadnoeuropskim državama (Njemačkoj, Velikoj Britaniji, Francuskoj, Nizozemskoj, Belgiji i Španjolskoj); međutim, podaci za Jugoistočnu Europu su ograničeni. Iz tog razloga, rizik od šišmiša kao rezervoara bjesnoće i njihov utjecaj na javno zdravstvo u ovoj regiji, uključujući i Hrvatsku, još su nepoznati. Potvrđeno je da u Hrvatskoj živi ukupno 35 različitih vrsta šišmiša, što je među najvećim obiljem vrsta u Europi. Sve vrste šišmiša za koje je potvrđeno da prenose bjesnoću prisutne su u Hrvatskoj i stoga bi mogle predstavljati i rizik za ljude. Iz tih razloga, predlažemo trogodišnji projekt aktivnog nadzora bjesnoće u šišmiša kako bi procjenili izloženost virusu EBLV i to u ciljanih vrsta šišmiša (Myotis myotis, M. schreibersii, Rhinolophus ferrumequinum i Eptesicus serotinus) iz tri glavne hrvatske biogeografske regije.]]></summary_hr><summary_en><![CDATA[Rabies is an ancient major zoonosis with the highest mortality of any known infectious agent that continues to cause considerable human illness and death. The prototypic classical rabies virus (RABV) of genotype 1 has reservoirs in species of the order Carnivora, and also in Chiroptera (bats) in the Americas. In Europe, two bat lyssaviruses, referred to as European bat lyssaviruses (EBLVs) types 1 and 2 (genotypes 5 and 6), are host restricted to bats, and have been known to infect not only their primary hosts but also to induce spillover infections to terrestrial mammals including domestic livestock, wildlife and man. EBLV infections in bats in Europe have been confirmed mainly in The Netherlands, Germany, Denmark and Poland. Since 1977, four human deaths from EBLVs have been reported. To date, most (>95%) viral isolates have been of EBLV type 1 and are predominantly associated with the serotine bat (Eptesicus serotinus), whereas EBLV type 2 appears to be associated with Myotis species. Active surveillance of bats to assess the prevalence of EBLV has been conducted in Western European countries (Germany, United Kingdom, France, Netherland, Belgium and Spain); however, data for Southeastern Europe are limited. For this reason, the risk of bats as a rabies reservoir and the impacts on public health for this region including Croatia are still unknown. A total of 35 bat species are known to inhabit Croatia, which is among the highest species richness in Europe. All bat species confirmed to carry rabies are present in Croatia, and therefore could represent a human health risk. For these reasons, we propose a three-year active surveillance project to assess the exposure of target bat species (Myotis myotis, M. schreibersii, Rhinolophus ferrumequinum and Eptesicus serotinus) from the three Croatian main biogeographical regions to EBLVs. ]]></summary_en></project><project>
<id>3140</id><title_hr><![CDATA[Programski sustavi u evoluciji: analiza i inovativni pristupi pametnom upravljanju]]></title_hr><title_en><![CDATA[Evolving software systems: anaysis and innovative approaches for smart management]]></title_en><user_id>1409</user_id><user_firstLast_name>Tihana Galinac Grbac</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2014-09</proposal_call><code>UIP-2014-09-7945</code><acronim><![CDATA[EVOSOFT]]></acronim><duration>01.07.2015 - 31.10.2018</duration><status>Završio</status><financ_value>78.877,17 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Računarstvo, </scie_field_hr><scie_field_en>Computer sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Tehnički fakultet]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Engineering]]></institution_en><team_members_id>2658, 5217, 3658, 13494, 1485, 5358, 20529, 21406, 22612, </team_members_id><team_members_names><![CDATA[Goran Mauša, Per Runeson, Fabrizio Montesi, Jean Petric, Ivan Štajduhar, Darko Huljenić, Nikola Tanković, Joao Costa, Ana Vranković, ]]></team_members_names><keywords_hr><![CDATA[evolucija, kompleksni softverski sustavi, pametno upravljanje, distribucije neispravnosti, struktura]]></keywords_hr><keywords_en><![CDATA[evolution, complex software system, smart management, fault distributions, structure]]></keywords_en><summary_hr><![CDATA[Kompleksni programski sustavi koji se evolucijski razvijaju (EVOSOFT) postali su središnji sve većeg broja aplikacija, proizvoda i usluga, a koji su potpora svakodnevnim ljudskim aktivnostima iz svih gospodarskih sektora. Često su to distribuirani sustavi , heterogeni , decentralizirani i međusobno zavisni, koji rade u dinamičnim i nepredvidljivim uvjetima, pa su njihova dostupnost i pouzdanost postale ključna svojstva potrebna za njihov rad i budući razvoj. Novoi još neistraženo područje istraživanja a koje se obrađuje u ovom projektu je razumjeti kako apstraktne programske strukture i lokalna obilježja sustava utječu na distribuciju neispravnosti, a čime se utječe na kritična svojstva sustava, među kojima je dostupnost i pouzdanost te razvijati inovativne pristupe za pametno upravljanje njihovim izvođenjem i evolucijom. Potrebno je za naglasiti da se ovdje suočavamo s potpuno novim pojavama, sličnim ljudskoj evoluciji, ali koje su proizvedene ljudskim intelektom. Temelji i teorije iz drugih disciplina kojima je cilj razumjeti ponašanje kompleksnih sustava, evolucije te ljudsko razmišljanje mogle bi ovdje biti primijenjive. Novi rezultati otvoriti će nove mogućnosti u mnogim znanstvenim područjima, osobito u teoriji kompleksnih sustava i njenih primjena, te tako međudjelovati sa širokim spektrom znanosti, od prirodnih znanosti kao što su to biomedicina pa sve do društvenih znanosti . Industrijsko iskustvo prikupljeno iz empirijskog pristupa programskom inženjerstvu je iznimno važno za daljnji razvoj discipline programskog inženjerstva. Nove teorije ne mogu biti djelotvorne i primjenjive u industriji, bez temeljnog razumijevanja EVOSOFT ponašanja . Glavni cilj ovog projekta je da će ispuniti taj jaz između empirijskih dokaza i teoretskih modela . Kako bi ostvarili taj cilj kombiniramo empirijska i teoretska znanja tako što ćemo:• ponoviti studije i potvrditi empirijske principe i metode i na kojima želimo graditi nove teorije ,• definirati strukturalne ovisnosti za primjenu empirijskih principa, metoda ,• definirati formalne modele i inovativne načine pametnog upravljanja .]]></summary_hr><summary_en><![CDATA[Evolving complex software systems (EVOSOFT) have become a central part of a rapidly growing range of applications, products and services supporting daily human activities from all economic sectors. As they are often distributed, heterogeneous, decentralized and inter-dependent, and operating in dynamic and unpredictable environments, availability and reliability become key properties for its operation and future evolution. The novel and still unexplored area of research addressed in this project is to understand how abstract software structures and local system properties influence fault distributions, thus affecting mission critical system properties, among which availability and reliability and to develop innovative approaches for smart management of their operation and evolution. We are facing with completely new phenomena, similar to human evolution, but produced by human intellect. Foundations and theories from other disciplines aiming to understand complex system behavior, evolution and human reasoning could be applied. New findings would open new opportunities in many scientific fields, especially in complex systems theory and its applications, thus interacting with a wide spectrum of sciences, from natural sciences such as biomedicine to social sciences. Industrial experience gathered by systematic Empirical Software Engineering approach is extremely important for further evolution of software engineering discipline. New theories cannot provide effective means for industry without fundamental understanding of EVOSOFT behavior. The main aim of this project is to fulfill this gap between empirical evidence and theoretical models. In that aim we combined empirical and theoretical skills aiming to: • replicate studies and confirm empirical principles and methods and define a solid base to ground new theories, • define structural dependencies for applicability of empirical principles, methods, • define formal models and innovative approaches for smart management.]]></summary_en></project><project>
<id>3144</id><title_hr><![CDATA[ADAPTIVNA PARAMETRIZACIJA PROMJENJIVIH 3D GEOMETRIJA KOD OPTIMIZACIJE OBLIKA I  BEZMREŽNOG NUMERIČKOG MODELIRANJA]]></title_hr><title_en><![CDATA[ADAPTIVE PARAMETERIZATION OF VARIABLE 3D GEOMETRIES IN SHAPE OPTIMIZATION AND MESHLESS NUMERICAL MODELING]]></title_en><user_id>3851</user_id><user_firstLast_name>Damir Vučina</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2014-09</proposal_call><code>IP-2014-09-6130</code><acronim><![CDATA[Optimal3D]]></acronim><duration>01.11.2015 - 31.10.2017</duration><status>Završio</status><financ_value>63.706,95 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Temeljne tehničke znanosti, Strojarstvo, </scie_field_hr><scie_field_en>Basic engineering sciences, Mechnical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Splitu, Fakultet elektrotehnike, strojarstva i brodogradnje]]></institution_hr><institution_en><![CDATA[University of Split, Faculty of Electrical Engineering, Mechanical Engineering and Naval Architecture]]></institution_en><team_members_id>13265, 5150, 4871, 4969, 4873, 4983, 13396, 21278, </team_members_id><team_members_names><![CDATA[Ivo Marinić-Kragić, Željan Lozina, Ivan Tomac, Igor Pehnec, Damir Sedlar, Zoran Milas, Milan Ćurković, Anđela Bartulović, ]]></team_members_names><keywords_hr><![CDATA[Adaptivna parametrizacija oblika, 3D geometrijsko modeliranje, particioniranje po značajkama, optimizacija oblika, bezmrežne metode]]></keywords_hr><keywords_en><![CDATA[Adaptive shape parameterization, 3D geometric modeling, Feature-based partitioning, Shape optimization, Meshless methods]]></keywords_en><summary_hr><![CDATA[Glavni cilj projekta je razvoj numerički efikasnog i dinamički adaptivnog parametarskog zapisa oblika koji donosi povećanu mogućnost modeliranja 3D oblika kako sam po sebi tako i za funkcije oblika u numeričkim metodama.Početni zapis oblika je oblak 3D točaka kakav se dobije sustavom digitalizacije oblika (3D optički sustav za skeniranje visoke razlučivosti). Matematička parametrizacija oblaka točaka zasnivati će se na parametarskim plohama. Integralna kao i po dijelovima povezana parcijalna parametrizacija biti će istražene i uspoređene.Proučavati će se dinamički aspekti parametrizacije. Oblik i posebno topologija objekta će se mijenjati u kvazivremenu simulacije/optimizacije. Za vrijeme procesa, rubovi i vrhovi mogu nestati, a novi se mogu pojaviti, zbog čega parametrizacija treba biti samostalno prilagodljiva na takve promjene.Proučavati će se strategije za redukciju parametarskog skupa nepoznanica na temelju dopuštenih graničnih vrijednosti pogrešaka u području značajki i na temelju ukupne normirane greške. Ove strategije uključuju prilagodljivu preraspodjelu kontrolnih točaka koristeći procedure za detekciju značajki temeljene na omjeru vlastitih vrijednosti i procjeni nagiba i zakrivljenosti. Vrednovati će se prilagodljiva podjela plohe cjelokupnog objekta na dijelove na temelju različitih kriterija.   Proces optimizacije uključuje opsežne izračune odnosno rješavanje problema polja opisanog parcijalnim diferencijalnim jednadžbama. Navedeni aspekti modeliranja oblika također se primjenjuju u bezmrežnim metodama gdje funkcija na domeni određuje numeričko rješenje danog problema polja. Razmotrit će se bezmrežne metode temeljene na &#39;&#39;oblaku&#39;&#39; čvorova koje su značajno manje osjetljive na promjene u konfiguraciji materijala.]]></summary_hr><summary_en><![CDATA[The project focuses on developing numerically efficient and dynamically adaptive parametric representations of shape which autonomously provide increased modeling capacity for the 3D shape itself and for the shape functions in numerical methods. The initial shape iteration will start from 3D point clouds, possibly resulting from shape digitization (existing high-resolution optical scanning system). Mathematical parameterization of the point clouds will be based on parametric surfaces. Integral as well as chained piecewise surfaces will be explored and compared. Dynamic aspects of the parameterizations will be studied. The shape and possibly topology of the object will be changing in simulation/ optimization quasi-time iterations. During the process, edges and peaks may disappear and new ones may arise, whereby the parameterization must be autonomously adaptable to such changes.Strategies for controlled reductions of the parameterization data-sets based on permissible threshold values for peak error and cumulative error norms will also be studied. These strategies will include adaptive re-allocation of the control points using feature recognition procedures (edges, peaks) based on eigenvalue ratios and slope and curvature estimators. Adaptive partitioning of the overall object surface based on different criteria will be evaluated.The optimization process involves extensive field calculations i.e. solving field problems governed by partial differential equations. The above shape modeling aspects also apply with meshless methods where a function across the domain determines the numerical solution of a given field problem. The option applied here will be meshless methods which are based on a nodes “cloud” and are dramatically less sensitive to the change in a material configuration.]]></summary_en></project><project>
<id>3145</id><title_hr><![CDATA[Metabolizam i interakcije biološki aktivnih spojeva i QSAR]]></title_hr><title_en><![CDATA[Metabolism and Interactions of Biologically Active Substances, and QSAR]]></title_en><user_id>3705</user_id><user_firstLast_name>MIRZA BOJIć</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2014-09</proposal_call><code>UIP-2014-09-5704</code><acronim><![CDATA[MAINBASE4QSAR]]></acronim><duration>01.09.2015 - 31.08.2018</duration><status>Završio</status><financ_value>43.134,91 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Farmacija, Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Pharmaceutical sciences, Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Farmaceutsko-biokemijski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Pharmacy and Biochemistry]]></institution_en><team_members_id>4758, 5248, 12989, 12991, 22519, 22518, </team_members_id><team_members_names><![CDATA[Hrvoje Rimac, Zeljko Debeljak, F. Peter Guengerich, Donghak Kim, Andrea Antolić, Goran Benković, ]]></team_members_names><keywords_hr><![CDATA[biološki aktivni spojevi, metabolizam, interakcije, citokromi P450, humani serumski albumin, QSAR]]></keywords_hr><keywords_en><![CDATA[biologically active substances, metabolism, interactions, cytochromes P450, human serum albumin, QSAR]]></keywords_en><summary_hr><![CDATA[U razvijenim su zemljama najučestaliji uzroci smrti krvožilne bolesti. Trombociti su uključeni u hemostazu, trombozu i upalni odgovor, a krvožilne bolesti mogu biti znak njihove patološke aktivacije. U prijašnjim smo radovima pokazali da biološki aktivne tvari, npr. flavonoidi mogu utjecati na agregaciju trombocita pri koncentracijama koje se mogu postići u krvi nakon konzumacije hrane bogatom polifenolima. Također mogu utjecati i na rezultate dijagnostičkih funkcionalnih ispitivanja agregacije trombocita. Daljne studije će se usredotočiti na njihov metabolizam, moguće interakcije i QSAR predviđanje učinka. Ciljevi našeg predloženog projekta su odrediti: 1. Metabolizam flavonoida-ovi spojevi se lako mogu metabolizirati, npr. oksidacijskim i (de)metilacijskim reakcijama; naš je cilj odrediti koji je oblici flavonoida su najzastupljeniji (izvorni spoj ili metaboliti) koristeći humane jetrene mikrosome, rekombinante jetrene citokrome P450 i LC-MS/MS. 2. Interakcije flavonoida-proučavat će se interakcije flavonoida s drugim često korištenim lijekovima na citokrom P450 enzimima (metaboličke interakcije), kao i vezanje flavonoida na humani serumski albumin (distribucijske interakcije). 3. Kvantitativna veza strukture i aktivnosti (QSAR)-na temelju rezultata ispitivanja metaboličkih i distribucijskih ispitivanja odredit će se QSAR modeli koji će dati uvid u strukturne karakteristike flavonoida odgovornih za interakcije i podložnost metabolizmu putem citokroma P450. Uz znanstveno, ovo istraživanje također ima i društveno i ekonomsko opravdanje. Učestalost krvožilnih bolesti u SAD-u u 2010. godini je bila 37%, što je rezultiralo s 444 milijarde dolara u troškovima. U EU se ovom problemu pristupa s posebnom pozornošću jer se u idućih 20 godina očekuje porast troškova od 40% povezanih s liječenjem ovih bolesti. Ta činjenica potiče znanstvenu, kao i farmaceutsku zajednicu da tragaju za boljim i sigurnijim lijekovima, s flavonoidima kao mogućim kandidatima.]]></summary_hr><summary_en><![CDATA[In developed countries, the most common causes of deaths are cardiovascular diseases. Platelets are involved in hemostasis, thrombosis and inflammation, and cardiovascular diseases may be a sign of pathological platelet activation. Prrviously we have shown that biologically active substances, i.e. flavonoids can affect platelet aggregation at concentrations that can be achieved in the blood after consumption of foods rich in polyphenols. Flavonoids may affect the diagnostic tests-functional tests of platelet aggregation. Further studies are to focus on metabolism of flavonoids, possible interactions, and their QSAR prediction. Goals of our proposed project are to determine: 1. Metabolism of flavonoids–these compounds can easily be transformed: oxidations, (de)methylations; thus our objective is to determine which forms are the most prominent ones (parent compound or metabolites) using human liver microsomes, recombinant liver cytochromes P450 and LC-MS/MS. 2. Interactions of flavonoids–interactions of flavonoids with other commonly used drugs on cytochrome P450 enzymes (metabolic interactions) as well as binding of flavonoids to human serum albumin (distribution interaction) will be studied. 3. Quantitative structure activity relationship (QSAR)–based on the results of metabolic and interaction studies, predictive QSAR models will be set giving insight into structural features of flavonoids responsible for interaction and susceptibleness to cytochrome P450 metabolism. In addition to scientific contributions, this research also has social and economic justification. The prevalence of cardiovascular diseases in the USA in 2010 was 37%, resulting in 444 billion USD of costs. In the EU this issue is addressed with special attention as an increase in costs of 40% for the treatment of these diseases is expected in the next 20 years. This drives scientific, as well as pharmaceutical community to search for a better and safer drugs, with flavonoids as prominent candidates.]]></summary_en></project><project>
<id>3148</id><title_hr><![CDATA[Novo poglavlje u procesima prijenosa naboja u vodenim otopinama]]></title_hr><title_en><![CDATA[Charge Transfer Processes in Aqueous Media Revisited]]></title_en><user_id>521</user_id><user_firstLast_name>Ivan Ljubić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2014-09</proposal_call><code>IP-2014-09-7540</code><acronim><![CDATA[CTPAMR]]></acronim><duration>01.09.2015 - 31.08.2019</duration><status>Završio</status><financ_value>112.416,22 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, </scie_field_hr><scie_field_en>Chemistry, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>3692, 3691, 88, 1205, 13203, 21411, 24440, </team_members_id><team_members_names><![CDATA[Marko Tomislav Cvitaš, Marija Bonifačić, Aleksandar Sabljić, Iva Dzeba, Brunislav Matasović, Ivana Nikšić-Franjić, Igor Sviben, ]]></team_members_names><keywords_hr><![CDATA[Radijacijska kemija, Kvantna kemija, Molekulska dinamika, Reakcijski mehanizam, Kinetika, Vodena otopina, Spregnuti prijenos protona i elektrona ]]></keywords_hr><keywords_en><![CDATA[Radiation chemistry, Quantum chemistry, Molecular dynamics, Reaction Mechanism, Kinetics, Aqueous solution, Proton-coupled electron transfer]]></keywords_en><summary_hr><![CDATA[Procesi prijenosa naboja u vodenom mediju od iznimnog su interesa zbog svoje ključne uloge u biokemiji i dizajnu sustava za pretvorbu energije. Unatoč opsežnim dugogodišnjim istraživanjima, načini prijenosa naboja i njihova ovisnost o reakcijskim uvjetima još su uvijek nedovoljno poznati. Sinergijskom kombinacijom eksperimentalnih i računskih pristupa nadamo se ostvariti značajan napredak u razumijevanju mehanizama i kinetike prijenosa naboja u reakcijama slobodnih radikala u vodenom mediju, posebice spregnutog prijenosa protona i elektrona (PCET). Težište će biti na reakcijama alfa-hidroksialkilnih i alfa-aminoalkilnih radikala s halogeniranim organskim supstratima te ovisnost prinosa dehalogenacije o prisutnosti i svojstvima pufera. U sličnim uvjetima planiramo studirati i reduktivna svojstva atoma vodika, što potencijalno pruža fascinantnu mogućnost istraživanja najfundamentalnijih aspekata PCET procesa. Istraživanja će se provoditi gama-radiolizom puferiranih vodenih otopina i kvantitativnim mjerenjima vrste i prinosa nastalih produkata u kombinaciji s kvantno-kemijskim i dinamičkim računalnim metodama, kako u svrhu racionaliziranja eksperimentalnih rezultata tako i za usmjeravanje eksperimenata. Budući da je PCET u ovim sustavima popraćen lančanom reakcijom koja znatno povećava prinose dehalogenacije, namjeravamo iznaći najpovoljnije uvjete za usmjeravanje reakcije u PCET kanal, posebice u odnosu na kompetitivne kanale radikalske supstitucije i adicije. Uspješno ostvarenje ciljeva projektnog prijedloga bitno će pridonijeti rješavanju središnjeg problema kemije slobodnih radikala u vodenim otopinama, tj. na koji način dizajnirati reakcijske uvjete, primjerice pH te koncentracije reaktanata i pufera, kako bi se radikalska reakcija učinkovito usmjerila prema određenom reakcijskom kanalu i na taj način optimizirao prinos produkata.]]></summary_hr><summary_en><![CDATA[Charge transfer processes in aqueous media are of a huge and ongoing interest due to their vital role in biochemistry and energy conversion applications. Despite extensive body of research invested in these processes, various modes of charge transfer and dependence thereof upon the reaction conditions are still insufficiently understood. By a synergistic combination of experimental and computational approaches, we hope to make major advances in understanding of the mechanisms and kinetics of charge transfer in free radical reactions in aqueous media, particularly of the proton-coupled electron transfer (PCET). Our focus will be on the reactions of the a-hydroxyalkyl and a-aminoalkyl radicals with halogenated organic substrates, and how the product yields of such a radical-induced dehalogenation are influenced by several buffer systems. In the similar context, we also plan to study reductive properties of the hydrogen atom, which offers a fascinating prospect of exploring the PCET process at its most fundamental. The reactions will be incited by the g-radiolysis of buffered aqueous solutions, followed by the detection and quantitative measurement of the products. This will be accompanied by quantum-chemical and molecular dynamical calculations, both to help rationalize the experimental findings and to guide the experiments. Because the PCET in these systems is remarkably accompanied by a chain reaction that greatly enhances the dehalogenation yields, we intend to elucidate the favorable conditions for the PCET to occur, especially as opposed to the rival free radical substitution and addition. A successful accomplishment of the objectives will be instrumental for resolution of the central problem in the aqueous chemistry of free radicals, and that is how to rationally design the specific reaction conditions, e.g. pH, reactant and buffer concentrations, in order to steer a free-radical induced reaction and optimize the yield due to a desired reaction channel.]]></summary_en></project><project>
<id>3149</id><title_hr><![CDATA[Uloga fosfoinozitida u nastanku trombocita]]></title_hr><title_en><![CDATA[The role of phosphoinositides in platelet formation]]></title_en><user_id>35</user_id><user_firstLast_name>Antonija Jurak Begonja</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2014-09</proposal_call><code>UIP-2014-09-2400</code><acronim><![CDATA[MkPI]]></acronim><duration>15.09.2016 - 31.12.2019</duration><status>Završio</status><financ_value>132.627,12 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Fakultet biotehnologije i razvoja lijekova]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Biotechnology and Drug Development]]></institution_en><team_members_id>6883, 13546, 24298, </team_members_id><team_members_names><![CDATA[Hana  Mahmutefendić, Ira Milosevic, Ana Bura, ]]></team_members_names><keywords_hr><![CDATA[megakariociti, trombociti, trombopoeza, endocitoza, fosfoinozitidi]]></keywords_hr><keywords_en><![CDATA[megakaryocytes, platelets, thrombopoiesis, endocytosis, phosphoinositides]]></keywords_en><summary_hr><![CDATA[Trombociti su neophodni za hemostazu te također posreduju u procesima različitih bolesti uključujući upale, metastaze, aterosklerozu. Liječenje leukemija i drugih malignih oboljenja ili transplantacije organa često dovode do smanjenja broja trombocita, te predstavljaju rizik od krvarenja. Trombociti nastaju iz citoplazme megakariocita (MK) u koštanoj srži u procesu trombopoeze. MK prolaze složen proces sazrijevanja koji vodi ka stvaranju dugih, razgranatih citoplazmatskih struktura – protrombocita. Molekularni mehanizmi koji reguliraju ove citoplazmatske promjene MK-a u velikoj mjeri su nepoznati. Naša preliminarna istraživanja pokazuju da određena vrsta fosfoinozitida (PI), fosfatidilinozitol 3-monofosfat (PI3P) ima glavnu ulogu u formiranju protrombocita u primarnim kulturama MK-a. U stanicama PI3P se nalazi u ranim endosomima i sudjeluje u endosomskom prometu. Naša je hipoteza da membranski promet reguliran PI3P-om u endocitnom putu znatno pridonosi biogenezi trombocita. Predloženi projekt istražit će točnu ulogu PI3P u stvaranju protrombocita. Koristit ćemo genetski napravljene  fluorescentne probe, tehniku koja se temelji na proteinskim domenama fuzioniranim s fluorescentnim proteinom eksprimiranim s retrovirusa, kako bi odredili lokalizaciju u stvarnom vremenu različitih PI u MK-ima i protrombocitima. Istražit ćemo kako interferencija PI3P funkcije utječe na sazrijevanje MK te utvrditi je li defekt ograničen na endosomski odjeljak. U svrhu utvrđivanja mehanizma djelovanja PI3P-a koristit ćemo genetski i farmakološki pristup kako bi ispitali je li progresija ranih u kasne endosome nužna za stvaranje trombocita. Osim toga, identificirat ćemo proteine koji vežu PI3P regulirajući endosomsku dinamiku važnu za stvaranje protrombocita. Ovo će istraživanje doprinijeti našem razumijevanju osnovnih molekularnih procesa trombopoeze koji bi mogli doprinijeti novim terapijskim strategijama u liječenju trombocitopenije.]]></summary_hr><summary_en><![CDATA[Platelets are essential for hemostasis and they also mediate diverse disease processes including inflammation, metastasis, atherosclerosis. Cancer and leukemia treatments or organ transplants often lead to reduced platelet numbers, putting patients at risk of bleedings. Platelets derive from cytoplasm of megakaryocytes (MKs) in the bone marrow in a process called thrombopoiesis. MKs undergo complex maturation process that leads towards extension of long, branched cytoplasmic structures called proplatelets that eventually release platelets. Molecular mechanisms that govern these elaborate cytoplasmic changes of MKs remain largely unknown. Based on primary MKs our preliminary studies show that one type of phosphoinositides (PIs), phosphatidylinositol 3-monophosphate (PI3P) has a major role in proplatelet formation. PI3P is concentrated in early endosomes and is involved in endosomal trafficking. Our hypothesis is that PI3P regulation of membrane traffic in the endocytic pathway contributes significantly to platelet biogenesis. This proposed project will reveal the exact role of PI3P in proplatelet formation. We will use genetically engineered fluorescent probes, a technique based on protein domains fused with fluorescent protein expressed from retroviruses, to define spatial and temporal localization of different PIs in MKs and proplatelets. We will investigate if interference of PI3P function affects MK maturation and examine if defect is confined to endosomal compartment. To determine mechanism of PI3P action we will use genetic and pharmacologic approaches to examine if progression of early to late endosomes is needed for platelet genesis. In addition, we will identify proteins  that act in concert with PI3P to regulate endosomal dynamics important for proplatelet formation. These studies will contribute to our understanding of basic molecular processes underlying thrombopoieses and might lead towards novel therapeutic strategies in treatment of thrombocytopenia.]]></summary_en></project><project>
<id>3156</id><title_hr><![CDATA[Heuristička optimizacija u kriptologiji]]></title_hr><title_en><![CDATA[Heuristic optimization in cryptology]]></title_en><user_id>6984</user_id><user_firstLast_name>Domagoj Jakobović</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2014-09</proposal_call><code>IP-2014-09-4882</code><acronim><![CDATA[EvoCrypt]]></acronim><duration>01.09.2015 - 31.08.2018</duration><status>Završio</status><financ_value>71.404,87 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Računarstvo, </scie_field_hr><scie_field_en>Computer sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id>12866, 13359, 13035, 13300, 13522, 13499, </team_members_id><team_members_names><![CDATA[Marin Golub, Nele Mentens, Ante Đerek, Stjepan Picek, Lejla Batina, Danko Ivošević, ]]></team_members_names><keywords_hr><![CDATA[heuristička optimizacija, evolucijski algoritmi, kriptografija, kriptoanaliza, sklopovska izvedba]]></keywords_hr><keywords_en><![CDATA[heuristic optimzation, evolutionary computation, cryptography, cryptanalysis, hardware implementation]]></keywords_en><summary_hr><![CDATA[Cilj ovoga projekta je primjena stohastičkih i determinističkih algoritama optimizacije, kao i metoda strojnog učenja, na aktualnim problemima u kriptologiji. U okviru projekta istražit će se učinkovitost optimizacijskih algoritama, s naglaskom na evolucijsko računanje, primijenjenih na probleme oblikovanja nelinearnih elemenata za kriptografske algoritme, kao što su Booleove funkcije i S-kutije. Dio nastojanja bit će posvećen i optimizaciji sklopovske izvedbe tih elemenata, prije svega u kontekstu povećavanja propusnosti. Osim toga, prijedlog razmatra i problem učinkovitog traženja parametara napada umetanjem pogreške. Kako bi rezultati projekta bili dostupni široj zajednici, dodatna namjena projekta je stvaranje odgovarajuće programske potpore i optimizacijskih algoritama u obliku pratećeg skupa programskih alata, kako bi se omogućila primjena rezultata istraživačima u ovome području.]]></summary_hr><summary_en><![CDATA[This proposal aims at successful application of stochastic and deterministic optimization algorithms, as well as methods from the machine learning community, to current problems in cryptology. The project will investigate the efficiency of stochastic optimization algorithms, with evolutionary computation in particular, applied to the problems of creating nonlinear primitives for cryptography, such as Boolean functions and S-boxes. A part of this goal will also be devoted to optimization of hardware implementations of those primitives, primarily in the context of throughput maximization. Additionally, the proposal considers the problem of efficient search for parameters of successful fault analysis. The results of the project would not be easily attainable to the wider community without an appropriate collection of software tools for evaluation of candidate solutions to these problems and appropriate optimization algorithms. The final objective of this project is the creation of an accompanying open-source software tool collection to facilitate usage by researchers in the field.]]></summary_en></project><project>
<id>3170</id><title_hr><![CDATA[Zelena sinteza organopaladijevih foto-osjetljivih spojeva]]></title_hr><title_en><![CDATA[Green Synthesis of Organopalladium Photosensitizers]]></title_en><user_id>112</user_id><user_firstLast_name>Manda Ćurić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2014-09</proposal_call><code>IP-2014-09-7984</code><acronim><![CDATA[GREENSENS]]></acronim><duration>15.10.2015 - 14.10.2019</duration><status>Završio</status><financ_value>82.819,03 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, </scie_field_hr><scie_field_en>Chemistry, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>1007, 12522, 3414, 3061, 362, 238, </team_members_id><team_members_names><![CDATA[Marina Juribašić Kulcsar, Krunoslav Juraić, Janez Plavec, Ana Budimir, Snježana Kazazić, Tonko Dražić, ]]></team_members_names><keywords_hr><![CDATA[mehanokemija, starenje, aktivacija C-H veze, mehanizam, spektroskopija, neinvazivni kromogeni i fluorogeni kemosenzori  ]]></keywords_hr><keywords_en><![CDATA[mechanochemistry, aging, C-H bond activation, organopalladium, mechanism, spectroscopy, non-invasive chromogenic and fluorogenic chemosensors]]></keywords_en><summary_hr><![CDATA[Zelena kemija je na čelu aktualnih zbivanja raznih istraživačkih područja u kemiji. Jedan od njezinih glavnih ciljeva je razvijanje učinkovitih preparativnih metoda za različite vrste postojećih i novih kemikalija bez korištenja otapala i uz nisku potrošnju energije. Izvedivost ovog temeljnog koncepta zelene kemije bit će pokazana na sintezi organopaladijevih kompleksa te će većina sintetskih koraka u ovom projektu biti provedena reakcijama u čvrstom stanju, upotrebom metoda ubrzanog starenja i mehanokemije. Prvu mehanosintezu organopaladijevih spojeva aktivacijom C-H veze paladijevim(II) acetatom nedavno je objavila naša grupa. Valja napomenuti da je aktivacija C-H veze od iznimne važnosti u sintetskoj organskoj kemiji. U okviru ovog projekta predlažemo razvijanje i primjenu metoda u čvrstom stanju za sintezu niza ciklopaladiranih aromatskih azo spojeva. Interes za organopalladijeve komplekse s konjugiranim C=C and N=N vezama proizlazi iz njihove jake apsorpcije i emisije svijetla u području niskih energija što ih kvalificira kao dobre kandidate za biomolekulske obilježivače. U tom pogledu, njihov afinitet prema ciljanim amino kiselinama, kratkim peptidima i nukleobazama istražit će se UV-vis and fluorescentnom spektroskopijom. Shodno navedenom, dodatna korist od predloženog projekta bit će niz novih kromogenih i fluorogenih kemosenzora.Struktura produkata u čvrstom stanju odredit će se rendgenskom difrakcijom, NMR, Raman i IR spektroskopijama. Mehanizam ciklopaladacije u čvrstom stanju istražit će se u realnom vremenu in situ praćenjem reakcija Raman spektroskopijom, te u otopini UV-vis i NMR spektroskopijama uz ESI spektrometriju masa. Optička svojstva kompleksa u čvrstom stanju i otopini odredit će se UV-vis and fluoroscentnom spektroskopijom. Eksperimentalni rezultati racionalizirat će se teorijskim istraživanjima da bi se objasnila izomerija kompleksa, priroda njihovih elektronskih prijelaza te da bi se dobila dodatna potvrda za mehanizam ciklopaladacije.]]></summary_hr><summary_en><![CDATA[Green chemistry is at the forefront of current developments of various research areas in chemistry. One of its major objectives is to develop efficient solvent-free and low-energy preparative methods for various classes of existing and new chemicals. The feasibility of this green-chemistry concept will be demonstrated on the synthesis of organopalladium complexes and the majority of synthetic steps in this project will be performed in the solid state by methods of accelerated aging and mechanochemistry. The first mechanosynthesis of organopalladium compounds via C-H bond activation, which is of exceptional importance in organic synthesis, by palladium(II) acetate has been recently reported by our group.Within this project we propose to develop and implement the solid-state methods for the synthesis of a series of cyclopalladated aromatic azo compounds. Interest in such complexes with conjugated C=C and N=N bonds arises from their strong absorption and emission in the low energy region, which qualifies them as good candidates for the biomolecular labels. In this regard, their affinity to target amino acids, short peptides and nucleobases will be studied by UV-vis and fluorescence spectroscopies. Consequently, an additional benefit of this project will be a series of new chromogenic and fluorogenic chemosensors.The solid-state structures of the products will be determined by X-ray diffraction, NMR, Raman and IR spectroscopies. The cyclopalladation mechanism in the solid state will be studied by in situ monitoring of the reactions using Raman spectroscopy, and in the solution by UV-vis and NMR spectroscopies along with the ESI mass spectrometry. The optical characteristics of complexes will be evaluated by UV-vis and fluorescence spectroscopies. The experimental results will be rationalized by theoretical studies in order to explain isomerism of complexes, the nature of their electronic transitions and to obtain additional support for the cyclopalladation mechanism.]]></summary_en></project><project>
<id>3172</id><title_hr><![CDATA[Fiziološki i stereokemijski važni kompleksi bakra(II) s aminokiselinama: molekulsko modeliranje kombinirano s eksperimentalnim istraživanjima]]></title_hr><title_en><![CDATA[Combined molecular modelling and experimental studies of physiologically and stereochemically important copper(II) amino acid complexes]]></title_en><user_id>11255</user_id><user_firstLast_name>Jasmina Sabolović</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2014-09</proposal_call><code>IP-2014-09-3500</code><acronim><![CDATA[CopperAminoAcidates]]></acronim><duration>01.09.2015 - 28.01.2021</duration><status>Završio</status><financ_value>59.724,73 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, Fizika, </scie_field_hr><scie_field_en>Chemistry, Physics, </scie_field_en><institution_hr><![CDATA[Institut za medicinska istraživanja i medicinu rada]]></institution_hr><institution_en><![CDATA[Institute for Medical Research and Occupational Health]]></institution_en><team_members_id>11285, 12798, 1141, 13157, 21234, </team_members_id><team_members_names><![CDATA[Marijana Marković, Michael Ramek, Draginja Mrvoš-Sermek, Gábor Szalontai, Jelena Budimčić, ]]></team_members_names><keywords_hr><![CDATA[bakar, aminokiseline, molekulsko modeliranje, DFT, MM, MD, rendgenska strukturna analiza, NMR čvrstog stanja, cis-trans izomerija, fiziološki spojevi]]></keywords_hr><keywords_en><![CDATA[copper, amino acids, molecular modelling, DFT, MM, MD, X-ray structure analysis, solid-state NMR, cis-trans isomerism, physiological compounds]]></keywords_en><summary_hr><![CDATA[Strukturna istraživanja kompleksa bis(amino acidato)bakra(II), Cu(aa)2, intenzivnije započeta prije oko 45 godina još traju jer su motivirana činjenicama da su to (1) biološki važni spojevi budući da sudjeluju u skladištenju i prijenosu bakra do mjesta u organizmu gdje u optimalnim koncentracijama taj esencijalan element ima važne fiziološke uloge, (2) modelni spojevi za vezivna mjesta za bakar u metaloproteinima, (3) stereokemijski zanimljivi spojevi. Unatoč intenzivnim eksperimentalnim istraživanjima fizioloških Cu(aa)2 posljednjih 40 godina, njihova kompletna geometrija u otopinama uglavnom je nepoznata. Naše je istraživanje bis(L-histidinato)bakra(II) primjenom teorije funkcionala gustoće (Density Functional Theory, DFT) prvo razjasnilo strukturu tog fiziološkog spoja u vodenoj otopini pri fiziološkim uvjetima (Eur J Inorg Chem 2014: 198). Nastavljajući se na naša prethodna istraživanja, glavni je cilj projekta dobiti nove rezultate o fizikalno-kemijskim svojstvima (strukture, energije, vibracije, cis-trans izomerija, konformacijske promjene) u vakuumu, vodenoj otopini i kristalnom okruženju izabranih Cu(aa)2 zbog njihove biološke važnosti i stereokemijske raznolikosti primjenom metoda molekulskog modeliranja (DFT, molekulska mehanika, molekulska dinamika) i eksperimentalnih metoda (rendgenska strukturna analiza, spektroskopija NMR čvrstog stanja). Očekujemo da ćemo kombiniranjem tim metoda pridonijeti rješavanju još uvijek neriješenih pitanja (1) točne geometrije u otopini i čvrstom stanju, (2) procesa na molekulskoj razini. Budući da je interes za istraživanje bakrovih kompleksa kao antiproliferacijskih spojeva znatno porastao u posljednjih nekoliko godina, a detaljna fizikalno-kemijska karakterizacija je prvi nužan korak u istraživanju, realno se očekuje da će novi rezultati pridonijeti otkrivanju novih lijekova. Rezultati istraživanja će značajno unaprijediti znanstvene spoznaje i primjene u bioanorganskoj kemiji, biofizici, biologiji i medicini.]]></summary_hr><summary_en><![CDATA[The structural studies of bis(amino acidato)copper(II) complexes, Cu(aa)2, which started intensively in the 1960s and continue up to date, have been motivated by the facts that these complexes are (1) biologically important as a part of the accessible physiological pool for transport and storage of an essential element copper, (2) appropriate models for copper-binding sites in metalloproteins, (3) sterochemically interesting compounds. Despite intensive experimental studies of physiological Cu(aa)2 during the last 40 years, their exact structures in solutions generally remain unresolved. Our density functional theory (DFT) study of bis(L-histidinato)copper(II) (Eur J Inorg Chem 2014: 198) is the first that clarified the structure of that physiological compound in aqueous solution at physiological conditions. Based on our previous studies, the main goal of the project is to obtain new results on the physico-chemical properties (structure, energy, vibrations, cis-trans isomerism, conformational changes) in different surroundings (vacuum, aqueous solution, solid state) of selected Cu(aa)2 because of their biological importance and stereochemical diversity by using the molecular modelling (DFT, molecular mechanics, molecular dynamics) and experimental (X-ray diffraction, solid-state NMR) methods. By combining these methods we expect to contribute to solving yet unresolved issues of (1) the exact geometries in solution and solid state, (2) the processes occurring at the molecular level. The new results will contribute to understanding the data required in the discovery of new potential drugs since the detailed physico-chemical characterisation is a necessary first step in the drug development. It is worth mentioning that the interest in copper coordination complex research as antiproliferative agents has markedly increased in the last few years. We expect our results to have an impact on applications in bioinorganic chemistry, biophysics, biology, and medicine. ]]></summary_en></project><project>
<id>3173</id><title_hr><![CDATA[Profesionalne aspiracije prema STEM zanimanjima tijekom osnovne škole: longitudinalno istraživanje odnosa postignuća, vjerovanja o vlastitim kompetencijama i interesa za zanimanja]]></title_hr><title_en><![CDATA[STEM career aspirations during primary schooling: A cohort-sequential longitudinal study of relations between achievement, self-competence beliefs, and career interests]]></title_en><user_id>1355</user_id><user_firstLast_name>Josip Burušić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2014-09</proposal_call><code>IP-2014-09-9250</code><acronim><![CDATA[JOBSTEM]]></acronim><duration>01.09.2015 - 31.08.2019</duration><status>Završio</status><financ_value>78.200,33 eur</financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Psihologija, </scie_field_hr><scie_field_en>Psychology, </scie_field_en><institution_hr><![CDATA[Institut društvenih znanosti Ivo Pilar]]></institution_hr><institution_en><![CDATA[Institute of Social Sciences Ivo Pilar in Zagreb]]></institution_en><team_members_id>6293, 5747, 6505, 13063, 13071, 13079, 3455, 3612, 12977, 12965, 21398, 21321, </team_members_id><team_members_names><![CDATA[Toni Babarović, Marija Šakić Velić, Ivan Dević, Mia Karabegović, Leila Selimbegovic, Dubravka Glasnović Gracin, Ina Reić Ercegovac, Tomislav Jagušt, Predrag Pale, Juraj Petrović, Mirta Blažev, Mara Šimunović, ]]></team_members_names><keywords_hr><![CDATA[STEM područje, odabir zanimanja, školska postignuća, pojam o sebi, longitudinalna istraživanja, učinci intervencija]]></keywords_hr><keywords_en><![CDATA[STEM, vocational interest, school achievement, self-concept, self-competence beliefs, longitudinal studies, effectiveness of interventions]]></keywords_en><summary_hr><![CDATA[U globaliziranom, brzo mijenjajućem svijetu, pitanja obrazovnog postignuća i aspiracija mladih prema pojedinim zanimanjima od izuzetnog su značaja. To se posebno odnosi na zanimanja u području znanosti, tehnologije, inženjerstva i matematike (STEM), tehnološki sofisticiranim i inovativnim zanimanjima važnim za društveni razvoj. Od devedesetih na ovamo naklonost mladih upravo za takva zanimanja stalno opada. Istraživači, nositelji politika i institucije poput EU suočeni su s jasnim podacima o evidentnom nedostatku studenata u STEM programima te nedostatku pojedinih STEM stručnjaka.Predloženi projekt temelji se na suvremenim teorijama akademskog postignuća, vjerovanja o vlastitoj kompetenciji u akademskoj domeni i interesa za zanimanja te je strukturiran oko tri glavna istraživačka cilja: (i) ispitati kako se kod učenika opći i specifični interesi za STEM zanimanja stvaraju te mijenjaju li se tijekom vremena; (ii) ispitati odnos školskog postignuća učenika i vjerovanja o vlastitoj kompetenciji s općim i specifičnim interesima za STEM zanimanja, te testirati da li se obrazac tih odnosa mijenja tijekom osnovnoškolskog obrazovanja; (iii) ispitati kako obitelji i spol/rod oblikuju opće i specifične interese učenika vezane uz STEM karijere.Projekt se temelji na longitudinalno-sekvencijalnom istraživačkom nacrtu, složenom metodološkom okviru koji dozvoljava sagledavanje ovakvih istraživačkih pitanja. Ukupno će biti praćeno 1920 učenika osnovnih škola i njihovih roditelja/staratelja, podijeljenih u tri dobne kohorte, koje će se longitudinalno ispitivati kroz tri vala mjerenja. Dodatni je cilj projekta implementirati STEM intervencijski program u osnovne škole te sagledati njegove učinke u kontekstu STEM zanimanja, gdje će se koristiti esperimentalni nacrt s testiranjem prije i nakon tretmana u dvije skupine. Očekujemo da će sve poduzete aktivosti povećati sadašnja znanja, biti poticajne drugim istraživačima, a stečeno znanje korisno učenicima, učiteljima i donositeljima odluka.]]></summary_hr><summary_en><![CDATA[In the globalized and rapidly changing world, the issues of young people’s educational achievement and career aspirations are extremely important. These issues are especially relevant in vocations in the fields of Science, Technology, Engineering and Mathematics (STEM), which are technologically sophisticated and important for the development of the society. Since 1990s the interest of youth for these vocations is declining. Researchers, national governments and authorities like EU operate with exact figures which clearly demonstrate a shortage of STEM graduates and a decline in number of STEM experts.  The proposed project is grounded in contemporary theories of academic achievement, self-competence beliefs and vocational interests and it is structured around three main research goals: (i) to examine how students’ general and specific STEM career aspirations are formed and how they change over time; (ii) to examine how students’ academic achievement and self-competence beliefs are related to their general and specific STEM career aspirations and how the pattern of relations among them changes during the course of primary schooling; (iii) to examine how students’ general and specific STEM career aspirations are shaped by their families and gender. The project is based on a longitudinal research design, as a suitable methodological framework for responding to these complex research questions. A total of 1920 primary school students and their parents/guardians will participate in the study. Students will be grouped in three age cohorts, which will be followed longitudinally through three measurement waves. The additional goal of the project is to implement a STEM intervention program in primary schools and evaluate its’ effects by using two-group pre- and post-test randomized experimental design. The project is intended to create new knowledge useful for researchers, students, teachers as well to create knowledge-based implications for relevant stakeholders.]]></summary_en></project><project>
<id>3183</id><title_hr><![CDATA[Kiralnost od akiralnih tekućih kristala]]></title_hr><title_en><![CDATA[Chirality from Achiral Liquid Crystals]]></title_en><user_id>564</user_id><user_firstLast_name>Andreja Lesac</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2014-09</proposal_call><code>IP-2014-09-1525</code><acronim><![CDATA[CALC]]></acronim><duration>01.06.2015 - 31.05.2017</duration><status>Završio</status><financ_value>63.176,06 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, Fizika, </scie_field_hr><scie_field_en>Chemistry, Physics, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>3232, 5194, 184, 3241, 3233, </team_members_id><team_members_names><![CDATA[Irena Dokli, Trpimir Ivšić, Darko Kontrec, Anamarija Knežević, Ana  Mikleušević, ]]></team_members_names><keywords_hr><![CDATA[dimeri, tekući kristali, kiralna samoorganizacija, konformacijska analiza, NMR]]></keywords_hr><keywords_en><![CDATA[dimers, liquid crystals, chiral self-assembly, conformational analysis, NMR]]></keywords_en><summary_hr><![CDATA[Danas su, materijali sa svojstvima tekućih kristala najpoznatiji po svojoj uspješnoj primjeni u industriji zaslona, a ipak pokazuju mnoštvo specifičnih svojstava koje predstavljaju veliki potencijal kako za nova temeljna istraživanja tako i za inovativnu primjenu povrh one u izradi zaslona. Prijedlog projekta se odnosi na nova istraživanja u području tekućih kristala u kojima se proučava stvaranje helikalnih struktura od molekula koje nisu kiralne, a proizlazi iz prethodnih istraživanja koja su pokazala da fleksibilno povezane dimerne molekule mogu pokazivati ovakvo ponašanje. Prema teorijskom modelu ova helikalna molekulska organizacija ne zahtijeva kiralnost molekule, već ju omogućava svinuti oblik molekule. Unatoč velikom broju studiranih dimera, samo kod nekoliko akiralnih dimernih molekula s neparnom poveznicom primjećena je neobična nematička faza s helikalnom molekulskom organizacijom. Obzirom na ograničena saznanja o helikalnoj organizaciji akiralnih molekula predloženi projket nastoji utvrditi odnos strukture i mezogenih svojstava molekule te povećati broj raspoloživih materijala. Rad predviđa sintezu i karakterizaciju mezogenih svojstava niza novih simetričnih dimera s varijacijama na svim relevantnim strukturnim dijelovima kako bi se istražila njihova uloga u molekuskoj organizaciji unutar tekuće-kristalne faze. Konformacijska analiza korištenjem DFT računa pružit će vrijedne informacije o utjecaju geometrije i elektronske strukture na molekulsko pakiranje, a NMR studija odabranih dimera omogučiti će uvid u međumolekulske interakcije unutar faze. Dakle, očekuje se da će kombinacija eksperimentalni, računalnih i spektroskopskih istraživanja pružiti značajne informacije o strukturnim i elektroničkim čimbenicima koji utječu na nastanak i stabilnost helikalne samoorganizacije što proširuje mogućnost za kontroliranu proizvodnju novih materijala za različite primjene npr. generatori male snage, umjetni mišić, itd.]]></summary_hr><summary_en><![CDATA[Nowadays, liquid crystalline materials are best known for their successful implementation in flat panel displays, and yet they exhibit a plethora of peculiar properties that offer enormous potential for fundamental science as well as innovative applications well beyond the displays sphere. The proposal addresses a fast-developing area of liquid crystal science in which bulk, helical arrangements are formed from constituents, which are not themselves chiral. The current proposal arises from previous work in which it was shown that flexibly linked, dimeric molecules may also exhibit this general behaviour. According to the theoretical model, the arrangement does not require molecular chirality, instead it can be facilitated simply by the shape of bent molecules. Among great number of studied dimers, only a few achiral odd-memebered dimeric molecules displayed an unusual nematic phase with helical molecular organization. Such an observation is unprecedented and the current proposal seeks to delineate the central structure/property correlations and expand the number of such materials available. The work proposed herein envisages synthesis and mesomorphic characterisation a range of novel symmetric dimers having modifications on all relevant structural moieties in order to unravel their role in molecular arrangement within the liquid crystalline state. Conformational analysis using DFT calculation will provide information on geometrical and electronic effects influencing molecular packing while NMR investigation of selected neat dimers will enable direct insight into intermolecular interactions within the phase. Thus, combined experimental, computational and spectroscopic studies will provide valuable information on structural and electronic factors influencing formation and stability of helical self-assembly and expands the possibility for controlled fabrication of novel materials for various applications ranging from micropower generators to artificial muscle.]]></summary_en></project><project>
<id>3187</id><title_hr><![CDATA[Dizajniranje mikrostrukture i funkcionalnih svojstava legura s prisjetljivosti oblika na bazi bakra]]></title_hr><title_en><![CDATA[Design of Microstructure and Functional Properties of Cu-based Shape Memory Alloys]]></title_en><user_id>557</user_id><user_firstLast_name>Mirko Gojić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2014-09</proposal_call><code>IP-2014-09-3405</code><acronim><![CDATA[DMFP-CuSMA]]></acronim><duration>01.07.2015 - 30.06.2019</duration><status>Završio</status><financ_value>111.111,55 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Metalurgija, Kemijsko inženjerstvo, </scie_field_hr><scie_field_en>Metallurgy, Chemical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Metalurški fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Metallurgy]]></institution_en><team_members_id>554, 285, 826, 550, 576, 1156, 2837, 21382, </team_members_id><team_members_names><![CDATA[Stjepan Kožuh, Robert Pezer, Tamara Holjevac Grgurić, Ivana Ivanić, Ladislav Vrsalović, Borut Kosec, Ivan Anžel, Dragan Manasijević, ]]></team_members_names><keywords_hr><![CDATA[Legure s prisjetljivosti oblika, lijevanje, razvoj mikrostrukture, toplinska obrada, funkcionalna svojstva, korozija]]></keywords_hr><keywords_en><![CDATA[Shape memory alloys, casting, microstructure evolution, heat treatment, functional properties, corrosion]]></keywords_en><summary_hr><![CDATA[Istraživanje u projektu usmjereno je na razvoj legura s prisjetljivosti oblika na bazi bakra. Glavni ciljevi projekta su: kontrola skrućivanja i optimizacija tehnologije lijevanja na temelju mikrostrukturne i termodinamičke simulacije, uspostavljanje korelacije između mikrostrukture i željenih mehaničkih svojstava Cu-SMA legura, optimizacija postupka toplinske obrade s ciljem postizanja željene mikrostrukture, usklađivanje parametara proizvodnje (npr. lijevanja), mikrostrukture i funkcionalnih svojstava legura te razvoj fizikalnog i termodinamičkog modela za predviđanje razvoja mikrostrukture. Predloženi projekt i ciljevi projekta obuhvatit će pripremu jedinstvenih SMA legura s potencijalnom primjenom u strojarstvu i elektronici. Aktivnosti projekta prikazane su kroz osam radnih paketa (RP): RP1-Dizajniranje legura mezoskopskim i mikroskopskim kompjutorskim modeliranjem, RP2- Termodinamičko modeliranje i izrada faznih dijagrama legura, RP3-Priprema pred-legura, RP4-Lijevanje legura i razvoj mikrostrukture, RP5-Toplinska obrada legura, RP6-Karakterizacija legura, RP7-Ispitivanje funkcionalnih svojstava legura, RP8-Upravljanje projektom. Lijevanje legura provest će se pomoću tri tehnologije: lijevanjem u kalupe, kontinuiranim lijevanjem i melt-spinning tehnikom. Legure će se karakterizirati različitim tehnikama (OM, SEM, EDS, TEM, XRD, DSC, DTA, AAS, itd.), kao i njihova funkcionalna svojstva (efekt memorije oblika, korozija i elektrokemijska svojstva, itd.). Postignuti rezultati će osigurati nove poveznice mikrostrukturnih, mehaničkih i funkcionalnih značajki legura te njihovu korelaciju s ciljem pomicanja granica pripreme, lijevanja i toplinske obrade ispitivanih legura. Ishodi prijedloga projekta su od interesa i prihvatljivi za mala i srednja poduzeća usmjerena na proizvodnju Cu-legura s prisjetljivosti oblika.]]></summary_hr><summary_en><![CDATA[The research in the project is focused on the development of Cu-based shape memory alloys (SMA). The main goals of the project are: solidification control and optimization of the casting technology based on the microstructural and thermodynamical simulation, establishing  relationships between microstructure and desired mechanical properties of Cu-SMA, optimization of heat treatment to achieve desired microstructure, fine tuning of the production technology parameters towards the definite microstructure and functional properties of alloys and development of the physical and thermodynamic models capable of anticipating microstructure evolution.The proposed goals pertain to the effort to prepare unique SMAs with potential application in machine-building and electronic purposes. Investigation in this project will consist of eight work packages: WP1-Computational alloy design aided by mesoscopic and microscopic modelling, WP2- Thermodynamic modelling and constitution of alloys phase diagrams, WP3-Preparation of master alloys, WP4-Casting of alloys and microstructure evolution, WP5-Heat treatment of alloys, WP6-Characterization of alloys, WP7-Testing of functional properties of alloys, WP8-Project management. Casting of alloys will be realized by three techniques: casting in moulds, continuous casting and melt spinning technique. Diverse methods for characterization of alloys (OM, SEM, EDS, TEM, XRD, DSC, DTA, AAS, etc.) as well as examination of their functional properties (shape memory effect, corrosion and electrochemical properties, etc.) will be used. The results achieved will provide novel relationships of microstructural, mechanical and functional properties of alloys and their correlations in order to shift the knowledge limit for preparation, casting and heat treatment of investigated alloys. Outcomes of the project proposal will be potentially acceptable for small and medium size companies focused to production of Cu-SMAs.]]></summary_en></project><project>
<id>3189</id><title_hr><![CDATA[Logika, pojmovi i komunikacija]]></title_hr><title_en><![CDATA[Logic, Concepts, and Communication]]></title_en><user_id>91</user_id><user_firstLast_name>Srećko Kovač</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2014-09</proposal_call><code>IP-2014-09-9378</code><acronim><![CDATA[LogiCCom]]></acronim><duration>15.06.2015 - 14.06.2019</duration><status>Prekinut</status><financ_value>67.237,37 eur</financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Filozofija, </scie_field_hr><scie_field_en>Philosophy, </scie_field_en><institution_hr><![CDATA[Institut za filozofiju]]></institution_hr><institution_en><![CDATA[Institute for Philosophy in Zagreb]]></institution_en><team_members_id>3883, 3843, 3876, 4482, 13057, 11242, </team_members_id><team_members_names><![CDATA[Kordula Swietorzecka, Majda Trobok, Gabriela Bašić, Goran Lojkić, Ivan Restović, Kristina Šekrst, ]]></team_members_names><keywords_hr><![CDATA[logika, pojam, ontologija, znanje, pragmatika, Kant, Bolzano, Frege]]></keywords_hr><keywords_en><![CDATA[logic, concept, ontology, knowledge, pragmatics, Kant, Bolzano, Frege]]></keywords_en><summary_hr><![CDATA[Cilj je projekta reafirmacija temeljne uloge pojmova kao intenzija u logici kao i formalne pragmatike porabe pojmova u zaključivanju. Taj se cilj želi postići  istraživanjem koje na unutrašnji način povezuje intenzionalni i pragmatički pristup logici.Istraživanje ima četiri glavna aspekta unutar kojih se želi pokazati osnovna uloga pojmova: logika pojmova, pojmovni temelji ontologije, pojmovni temelji znanja i  društvena pragmatika pojmova.1) Istražit će se intenzionalna narav pojmova kao osnovanih na logičkim radnjama apstraktnih činitelja koji zaključuju (apstraktna pragmatika). Ispitat će se moguće intenzionalno podrijetlo klasičnih logičkih zakona. Pojmovima će se pristupiti  sa stajlišta logike prvoga reda i teorije tipova. Želi se ispitati hipoteza prema kojoj se intenzionalna logika i logički pojmovi mogu opisati pomoću pojmova objektivnosti i (prema Gödelovoj hipotezi)  uzročnosti.2) Ispitat će se intenzionalna bit temeljnih ontologijskih pojmova na primjeru  formalizacije Bolzanove ontologijske teorije, u usporedbi s Leibnizovom ontologijom. Istraživanje će se usredotočiti na pojmove supstancije, adherencije/inherencije i cjelina-dio.3) Želi se pokazati doprinos pojmova objektivnoj vrijednosti znanja, osobito  u  matematici, i u oslonu na Fregeovu teoriju pojmova. Posebno će se istraživati međuodnos pojmovnoga i predmetnoga sadržaja u analitičnim iskazima i iskazima prvoga reda.4) Analizirat će se uzročna uloga logičkih pojmova i jezika u kontekstu njihove porabe u govornim činovima i argumentacijskome dijalogu. Pokazat će se da je pragmatika bitna sastavnica logike, te da se, kao i sintaksa i semantika, može rigorozno formalizirati. Ktomu, istraživanje želi pokazati da je uporaba logike i jezika primarni izvor opisa pojmova.]]></summary_hr><summary_en><![CDATA[The project aims at re-establishing the fundamental role of concepts as intensions in logic as well as of formal pragmatics of the use of concepts in reasoning. This aim is to be achieved by means of the research that will intrinsically interconnect the intensional and pragmatic approach to logic. The research has four main aspects within which the basic role of concepts is aimed to be shown: logic of concepts, conceptual foundations of ontology, conceptual foundations of knowledge, and social pragmatics of concepts.1) The intensional nature of concepts will be investigated as based on logical operations of abstract reasoning agents (abstract pragmatics). A possible intensional origin of classical logical laws will be examined. Concepts will be approached in first-order and type-theoretical setting as well. One hypothesis to be examined is that intensional logic and logical concepts can be described in terms of objectivity and (according to Gödel’s hypothesis) in terms of causality.2) The intensional nature of some fundamental ontological concepts will be examined on the example of the new formalization of Bolzano’s ontological theory, in comparison Leibniz&#39;s  ontology. The research will focus on the concepts of substance, adherence/inherence, and whole-part.3) The contribution of concepts to the objective value of knowledge is aimed to be shown, especially in mathematics, and starting from Frege’s theory of concepts. Especially, the interrelationship of the conceptual and objectual content in analytic and first-order propositions will be investigated.4) The causal role of logical concepts and language in the context of their use in speech acts and argumentative dialogue will be analysed. Pragmatics will be shown to be an essential constituent part of logic, which is, like syntax and semantics, apt to be rigorously formalized. In addition, the research aims to show that the use of logic and language is a primary source of the description of concepts.]]></summary_en></project><project>
<id>3190</id><title_hr><![CDATA[Potraga za aksionima i njima sličnim česticama]]></title_hr><title_en><![CDATA[Search for axions and axion-like particles]]></title_en><user_id>1471</user_id><user_firstLast_name>Biljana Lakić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2014-09</proposal_call><code>IP-2014-09-3720</code><acronim><![CDATA[SAALP]]></acronim><duration>01.05.2015 - 31.10.2017</duration><status>Završio</status><financ_value>44.409,05 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, </scie_field_hr><scie_field_en>Physics, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>1086, 619, 501, 1037, 5714, </team_members_id><team_members_names><![CDATA[Krešimir Jakovčić, Milica Krčmar, Ante Ljubičić, Marin Karuza, Nenad Kralj, ]]></team_members_names><keywords_hr><![CDATA[eksperimentalna fizika, tamna tvar, aksion, čestice slične aksionima, lagane čestice s vrlo slabim međudjelovanjima, CAST, IAXO]]></keywords_hr><keywords_en><![CDATA[experimental physics, dark matter, axion, axion-like particle, weakly interacting slim particles, CAST, IAXO]]></keywords_en><summary_hr><![CDATA[Cilj predloženog projekta je istražiti postojanje i svojstva nekih čestica koje su kandidati za tamnu tvar u svemiru. Najnoviji podaci pokazuju da se svemir sastoji od obične tvari (4.9%), tamne tvari (26.8%) i tamne energije (68.3%). Jedan od glavnih pravaca istraživanja u današnjoj fizici usmjeren je na otkrivanje sastava tamne tvari. Prema sadašnjim spoznajama većinu tamne tvari čine čestice koje do sada još nisu opažene nego je njihovo postojanje samo predviđeno u raznim proširenjima Standardnog modela čestica. Prema tim teorijama postoje dva glavna kandidata za tamnu tvar. To su tzv. masivne čestice s vrlo slabim međudjelovanjima (WIMP od eng. Weakly Interacting Massive Particles) i aksion – lagani pseudoskalar koji se pojavljuje kao posljedica spontanog lomljenja U(1) Peccei-Quinn simetrije izvorno uvedene radi objašnjenja odsustva narušenja CP simetrije u jakim međudjelovanjima. Poopćenjem tog koncepta predviđeno je postojanje mnoštva čestica sličnih aksionima (ALP od eng. axion-like particles). Kao mogući kandidati za tamnu tvar spominju se i razne lagane čestice s vrlo slabim međudjelovanjima (WISP od eng. Weakly Interacting Slim Particles) predviđene u nekim proširenjima Standardnog modela, kao npr. parafotoni i kameleoni. Unatoč velikom broju hipoteza postavljenih s ciljem objašnjenja koje čestice čine tamnu tvar, samo eksperimenti mogu pokazati koja od njih je točna.U predloženom projektu planiramo nastaviti i proširiti potragu za aksionima, ALPovima i WISPovima u eksperimentima CAST (CERN Axion Solar Telescope) - trenutno najosjetljivijem aksionskom helioskopu i njegovom nasljedniku IAXO (International Axion Observatory). Otkriće tih čestica bilo bi revolucionaran rezultat jer bi to bio jasan dokaz o postojanju fizike izvan Standardnog modela. Međutim, čak i ako se ne otkriju te čestice, isključiti će se velik dio do sada neistraženog parametarskog prostora tih čestica što je također vrlo važan rezultat.]]></summary_hr><summary_en><![CDATA[The goal of the proposed project is to search for and study several candidates for the dark matter. Recent data from the Planck mission show that our Universe contains 4.9% ordinary matter, 26.8% dark matter and 68.3% dark energy. One of the major efforts in particle physics today is to reveal the composition of the dark matter. Nowadays, it is known that neutrinos constitute only a tiny fraction of the dark matter, while the rest is made of yet unobserved particles theoretically predicted in various extensions of the Standard Model. Two leading dark-matter candidates are the Weakly Interacting Massive Particles (WIMPs), and the axion - a light pseudoscalar associated with the spontaneous breaking of U(1) Peccei-Quinn symmetry, a mechanism originally introduced to explain the absence of CP violation in strong interactions. This concept has been generalized to further axion-like particles (ALPs), which may arise as Nambu-Goldstone bosons from the breaking of various global symmetries.  Possible dark matter candidates also include so-called WISPs, i.e., a variety of sub-eV (or slim) weakly-coupled particles such as hidden-sector photons and chameleons. A large number of theoretical ideas and hypotheses have been put forward to explain what the dark mater particles are, but only experimental data will be able to answer which, if any, of these ideas is correct. In the proposed project we are planning to continue and extend searches for axions, ALPs, and WISPs in experiments CAST (CERN Axion Solar Telescope) - currently the most sensitive axion helioscope in the world and its successor IAXO (International Axion Observatory). The discovery of such particles would be a ground-breaking result for particle physics since it would be a clean evidence of physics beyond Standard Model, but even in case of non-detection, CAST and IAXO will be able to exclude large parts of yet unexplored regions of the relevant parameter spaces for these particles.]]></summary_en></project><project>
<id>3204</id><title_hr><![CDATA[Multiferoični i magnetoelektrični sustavi]]></title_hr><title_en><![CDATA[Multiferroic and magneto-electric systems]]></title_en><user_id>2787</user_id><user_firstLast_name>Damir Pajić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2014-09</proposal_call><code>UIP-2014-09-8276</code><acronim><![CDATA[FerMaEl]]></acronim><duration>01.06.2015 - 31.10.2019</duration><status>Završio</status><financ_value>115.336,12 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, </scie_field_hr><scie_field_en>Physics, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>2873, 634, 12831, 6058, 4933, 5693, 6173, 20695, </team_members_id><team_members_names><![CDATA[Nikolina Novosel, Mirta Rubčić, Marijana Jurić, Filip Torić, Vito Despoja, Krešo Zadro, Emil Babić, Jure Dragović, ]]></team_members_names><keywords_hr><![CDATA[multiferoici, magneto-električni učinak, metalni oksidi, metalo-organske mreže, magnetizacija, polarizacija, teorija funkcionala gustoće]]></keywords_hr><keywords_en><![CDATA[multiferroics, magneto-electric effect, metallic oxides, metal-organic frameworks, magnetization, polarization, density functional theory]]></keywords_en><summary_hr><![CDATA[Multiferoici su materijali u kojima istovremeno postoje i magnetsko i električno uređenje, što je važno i za temeljnu fiziku i za primjene, poglavito zbog mogućeg vezanja dvije vrste reda. Iako mnogi materijali pokazuju posredne znakove magneto-električnog vezanja, izravne eksperimentalne činjenice mogle bi unaprijediti naše znanje o mehanizmima vezanja i postojanja dva uređenja. Stoga bi nadogradnja postojećih SQUID i VSM magnetometara omogućujući istraživanje utjecaja električnog polja na magnetizaciju, kao i izgradnja instrumentacije za mjerenje električne polarizacije  u primijenjenom magnetskom polju unutar postojećih kriostata, otvorila široke mogućnosti za magneto-električno istraživanje multiferoika. Multiferoičnost se javlja u različitim skupinama materijala, a istraživanje će biti usmjereno na one obećavajuće. Nove metalo-organske mreže vrlo su perspektivne, te ćemo raditi na njihovoj sintezi i modifikacijama, radi razumijevanja i utjecanja na njihovo magneto- električno ponašanje. Također, ne-centrosimetrični miješani metalni oksidi, kao i njihove nanočestice, pružaju široke mogućnosti  sinteze i modifikacije multiferoičnih svojstava. Predloženo multidisciplinarno istraživanje rezultiralo bi novim spojevima i izgrađenom aparaturom za potpunu magnetsku i električnu karakterizaciju potrebnu pri istraživanju multiferoika, dajući cjelovit skup eksperimentalnih činjenica upotpunjenih detaljnim teorijskim računima. Zajednički rad doveo bi do razvoja nezavisne istraživačke karijere i nastanka nove istraživačke skupine, jačajući suradnju i izobrazbu. Sveukupno bi omogućila plodno okruženje za kompetitivnu uključenost u istraživanja na svjetskoj razini unutar te aktualne teme u fizici čvrstog stanja i znanosti o materijalima, okupljanjem ljudskih i drugih znanstvenih resursa oko proizvodnje novih multiferoičnih sustava te njihovog cjelovitog eksperimentalnog i teorijskog proučavanja.]]></summary_hr><summary_en><![CDATA[Multiferroics are materials where the magnetic and electric orders coexist, being important for fundamental physics and applications, especially due to possible coupling of the two orders. While many materials show the indirect signs of the magneto-electric coupling, the direct experimental evidences could still improve our knowledge about mechanisms of the coupling and coexistence of two orders. Therefore, the upgrade of the existing SQUID and VSM magnetometers enabling investigation of influence of the electric field onto the magnetization, and also build up of instrumentation for measurement of electric polarization in applied magnetic field, would open large possibilities for magneto-electric research of the multiferroics. Multiferroicity appears in different groups of materials and investigation would be focussed on especially promising. New metal-organic frameworks are very perspective, and we will be working on their synthesis and modifications, in order to understand and influence their magneto-electric behaviour. Further, non-centrosymmetric metallic oxides, as well as their nanoparticles, offer large possibilities for the synthesis and modification of multiferroic properties. Proposed multidisciplinary research would result with the novel compounds and installed equipment for complete magnetic and electric characterization needed in research of multiferroics, giving integral set of experimental results, supplemented with detailed theoretical calculations. Joint work would lead to development of the independent research careers and growth of new team, strengthening the collaboration and education. It would enable the fertile environment for the competitive involvement in the research at international level within this state-of-the-art topic of condensed matter physics and materials science, because of assembling the human and other scientific resources around production of the new multiferroic systems and their complete experimental and theoretical study.]]></summary_en></project><project>
<id>3214</id><title_hr><![CDATA[Subplate zona ljudskog mozga: neriješeni problemi]]></title_hr><title_en><![CDATA[Subplate zone of the human brain: unsolved problems]]></title_en><user_id>12951</user_id><user_firstLast_name>Ivica  Kostović</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2014-09</proposal_call><code>IP-2014-09-4517</code><acronim><![CDATA[HUMANSUBPLATE]]></acronim><duration>01.01.2016 - 31.12.2019</duration><status>Završio</status><financ_value>132.722,81 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb School of Medicine]]></institution_en><team_members_id>7740, 12673, 12564, 12680, 12767, 12640, 12758, 13017, 12900, 12824, 4298, 12740, 12815, 23535, 23501, 25350, 25408, 25356, 22457, 22464, </team_members_id><team_members_names><![CDATA[Miloš Judaš, Dora Mandić, Ana Katušić, Branka Bartolić Spajić, Branka Bunoza, Valentina Galkowski, Ana Jagušt, Božica Popović, Danica Budinšćak, Marina  Raguž, Milan Radoš, Mirna  Kostović Srzentić , Vesna Benjak, Ruža Grizelj, Tomislav Ćaleta, Ana Bogdanić, Gabriela Plosnić, Lana Vasung, Iris Žunić Išasegi , Tomislav Gojmerac, ]]></team_members_names><keywords_hr><![CDATA[subplate, prematurus, vulnerabilnost, moždana kora, razvitak]]></keywords_hr><keywords_en><![CDATA[subplate, preterm infant, vulnerability, cortex, development]]></keywords_en><summary_hr><![CDATA[Subplate zona je najistaknutiji i najvoluminozniji arhitektonski odjeljak stijenke telencefalona u mozgu čovjeka, s ključnom ulogom u razvoju neuronskih veza moždane kore. Istraživanja su pokazala da ta zona ima rano razvojno porijeklo, sadrži brojne sinapse i neurone složenih citoloških svojstava i molekularne raznovrsnosti, uključena je u razvoj aferentnih aksona iz talamusa, kao i uspostavu privremenih neuronskih veza, prolaznu ekspresiju neurotransmitera, neuronskih krugova moždane kore i njihovu funkcionalnu specifikaciju, evoluciju moždane kore te patogenezu neuroloških, kognitivnih i mentalnih poremećaja. Brojna pitanja bitna za humanu razvojnu neurobiologiju ostala su neriješena: Kako se subplate povećava tijekom trudnoće? Kakva je sublaminarna, sinaptička, neuronalna i glijalna organizacija? Kakva je uloga u migraciji neurona? Kakvi su odnosi subplatea s dugim asocijativnim kortiko-kortikalnim vezama? Kakva je postnatalna sudbina? Postoji li selektivna vulnerabilnost subplate neurona i različitih klasa aksona i kako to prikazati u in vivo MRI? Naša je hipoteza da će veličina, karakteristični neuralni sadržaj i produljeni razvitak zajedno s karakterističnim svojstvima na MRI omogućiti prikaz onih karakterističnih osobina ljudskog subplatea koje su povezane sa složenošću kortikalnih veza. Specifični ciljevi su određeni da odgovore na gore navedena pitanja, primjenom histoloških, imunocitokemijskih i in vitro, in utero te in vivo MRI tehnika u mozgu čovjeka, kao i usporedbom tih podataka s nalazima u majmuna tretiranih s H3-Thymidine markerom replikacije DNA (Rakic, Yale). Rezultati ovog projekta će omogućiti bolji uvid u razvitak osjetljivog mozga fetusa i prijevremeno rođene djece, proširiti normativne podatke za pedijatrijski neuroimaging i studije praćenja koje su usmjerene na razvoj kortikalnih veza, te omogućiti dobre polazne osnove za istraživanje neuroloških, kognitivnih i mentalnih poremećaja, koji imaju utjecaj na društvo. ]]></summary_hr><summary_en><![CDATA[Subplate zone is the most prominent and voluminous, connectivity related, compartment of the cerebral wall of developing primate brain playing different developmental roles. Studies of this enigmatic neuronal compartment in human brain and experimental models have demonstrated early origin, synapse-rich content, complex cytology and molecular diversity, involvement in growth of thalamo-cortical fibres, transient connectivity and transmitter expression, functional specificity, role in formation of cortical circuitry, evolutional significance and prospective role in pathogenesis of neurological, cognitive and mental disorders. Review of the current literature indicate gaps in the our knowledge and existence of unsolved problems regarding secondary expansion of subplate, sublaminar distribution of synapses and different phenotypes of migratory and postmigratory neurons, transformation of radial glia, pattern of growth of long associative cortico-cortical pathways and vulnerability of subplate (axons, neurons and glia in preterm infant). It is our hypothesis that size characteristic neuronal content and prolonged development, together with MR imaging properties, will facilitate demonstration of those characteristic features of the human (primate subplate), which are related to the complexity of cortical connectivity. In this project, we will use histological, immunocytochemical and MR imaging techniques (in vitro and in vivo) for developing human brain, as well as comparative analysis of experimental non-human primate (provided by dr. Rakic, Yale) in order to give answers for unsolved problems in human SP neurobiology. We expect to demonstrate characteristic features of the human subplate related to complex cortical connectivity, develop new diagnostic criteria for MR imaging and follow-up of perinatally damaged brain and define novel normative data necessary for study of developmental neurological, cognitive and mental disorders, which have severe impact on society.]]></summary_en></project><project>
<id>3217</id><title_hr><![CDATA[Prema kvantnoj gravitaciji: nekomutativna geometrija, teorija polja i kozmologija]]></title_hr><title_en><![CDATA[Toward quantum gravity: noncommutative geometry, field theory and cosmology]]></title_en><user_id>1041</user_id><user_firstLast_name>Stjepan Meljanac</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2014-09</proposal_call><code>IP-2014-09-9582</code><acronim><![CDATA[tqgngftc]]></acronim><duration>01.09.2015 - 30.11.2017</duration><status>Završio</status><financ_value>66.361,40 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, </scie_field_hr><scie_field_en>Physics, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>12415, 12532, 2912, 3128, 3176, 2750, 12905, 1153, </team_members_id><team_members_names><![CDATA[Nevenko Bilić, Silvije Domazet, Josip Trampetić, Raul Horvat, Jiangyang You, Tajron Jurić, Danijel Pikutić, Anđelo Samsarov, ]]></team_members_names><keywords_hr><![CDATA[kvantna gravitacija, nekomutativna geometrija, teorija polja, kozmologija, simetrije]]></keywords_hr><keywords_en><![CDATA[quantum gravity, noncommutative geometry, field theory, cosmology, symmetries]]></keywords_en><summary_hr><![CDATA[Predloženi projekt ima za cilj provođenje istraživanja o različitim aspektima kvantne gravitacije, matematičke fizike, određenim temama u kozmologiji, astro fizici i fizici crnih rupa. Dok  zadovoljavajuća teorija kvantne gravitacije i dalje ostaje nedostižna, neka od procijenjenih svojstava, otkrivajući nelokalni karakter takve teorije (odnosno nekomutativnost prostorno-vremenskih koordinata, UV/IR  miješanje i holografski princip) već su promijenila našu perspektivu pomirenja  kvantne teorije polja (QFT) s općom teorijom relativnosti. Posebna pažnja posvetiti će se izgradnji, klasifikaciji i unifikaciji nekomutativnih (NC) prostora. U vezi s tim, moguće je definirati proceduru korištenjem rigoroznih tehnika kvantne deformacije kao i nekih dobro poznatih koncepata diferencijalne algebre i Hopfove algebre. To omogućuje formulaciju i proučavanje twist-deformirane Riemannove geometrije, twist verzije Einsteinovih jednadžbi i algebarskih struktura na kapa-deformiranom prostoru Minkowskog. Daljnji nastavak tih ideja otvara mogućnost proučavanja NC efekata u  crnim rupama. Osim toga, pomoću alata  QFT u zakrivljenom prostoru-vremenu, biti će pokriveno više aspekata moderne kozmologije, uključujući one koje se temelje na najuspješnijem ostvarenju holografskog principa –  AdS/ CFT dualnosti. Konačno, klasa modela kvantne gravitacije  bit će ispitana testiranjem narušenja Lorentzove invarijantnosti u promatranju brzo-promjenljivih astrofizičkih izvora visoko  energijskih gama-zraka. To zahtijeva potpuni model teorije polja  u kojem se ne javljaju problemi pri računanju  kvantnih petlji, tako da su  sve UV i IR patologije  pod kontrolom.]]></summary_hr><summary_en><![CDATA[The proposed project aims at carrying out research on various aspects of quantum gravity, related areas of mathematical physics, certain topics in cosmology, astroparticle physics and physics of black holes. Whereas a satisfactory theory of quantum gravity still remains elusive, some of the assessed properties revealing a nonlocal character of such a theory (i. e. noncommutativity of spacetime coordinates, UV/IR mixing and the holographic principle) has already changed our perspective upon reconciliation of the  quantum field theory (QFT) framework with general relativity. A particular attention will be paid to construction, classification and unification of NC spaces. In this regard, a procedure can be defined by making use of rigorous quantum deformation techniques as well as some well known differential algebra concepts and also  the Hopf algebra methods. This permits formulation and study of the twist-deformed Riemannian geometry, the twisted version of Einstein&#39;s equations and the algebraic structure on kappa-deformed Minkowski space. A further extension of these ideas opens  a possibility to study NC effect in black holes. Furthermore, using the tools of QFT in curved spacetime, several aspects of modern cosmology will be covered including those based on the most successful realization of the holographic principle - the AdS/CFT duality. Finally, a class of quantum gravity models will be tested by probing Lorentz violation in observations of rapidly-varying astrophysical sources of high-energy gamma-rays. This requires a full-fledged field-theoretical model with a trouble-free and meaningful quantum loop results, with all UV and IR pathologies being under control.]]></summary_en></project><project>
<id>3220</id><title_hr><![CDATA[Kronične upalne bolesti crijeva u djece: incidencija, tijek bolesti te uloga prehrane i crijevne mikroflore u etiopatogenezi]]></title_hr><title_en><![CDATA[Pediatric inflammatory bowel disease: incidence and natural history, and the role of diet and gut flora in etiopathogenesis]]></title_en><user_id>5694</user_id><user_firstLast_name>Sanja Kolaček</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2014-09</proposal_call><code>IP-2014-09-3788</code><acronim><![CDATA[PED-IBD]]></acronim><duration>01.03.2016 - 31.03.2020</duration><status>Završio</status><financ_value>106.178,25 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Kliničke medicinske znanosti, Javno zdravstvo i zdravstvena zaštita, </scie_field_hr><scie_field_en>Clinical sciences, Public health and health services, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu]]></institution_hr><institution_en><![CDATA[University of Zagreb]]></institution_en><team_members_id>2694, 5757, 4001, 5833, 4795, 2960, 4107, 25201, </team_members_id><team_members_names><![CDATA[Iva Hojsak, Ana Močić Pavić, Marko Jelić, Goran Palčevski, Zrinjka Mišak, Irena Senecic-Cala, Arjana Tambić - Andrašević, Ivana Trivić, ]]></team_members_names><keywords_hr><![CDATA[upalne bolesti crijeva, djeca, crijevna flora, enteralna prehrana, incidencija, registar]]></keywords_hr><keywords_en><![CDATA[inflammatory bowel disease, children, enteral nutrition, incidence, registry]]></keywords_en><summary_hr><![CDATA[Etiologija i patogeneza kroničnih upalnih bolesti crijeva (IBD - inflammatory bowel disease), unatoč visokoj prevalenciji, nisu razjašnjene. Predloženi mehanizam uključuje interakciju neodgovarajućeg (aberantnog) imunološkog odgovora na crijevnu mikrofloru / crijevni sadržaj, u genetski predisponiranih osoba. Cilj je ovog istraživačkog projekta pridonijeti rasvjetljavanju navedene patogeneze.Ciljevi. 1. Prehrana. Bolesnici s IBD-om vrlo često izbjegavaju određene namirnice u prehrani, pridajući im – po njihovu bolest – neželjena svojstva. Međutim, učinak takvih samonametnutih dijeta nije do sada istražen i za takve dijetetske postupke zasad nema znanstveno utemeljnog opravdanja. Od posebne je to važnosti za djecu u koje ozbiljnije dijetetske restrikcije mogu imati dugoročne posljedice na rast i razvitak. Stoga je prvi cilj ovog projekta utvrditi učestalost samoiniciranih dijeta u djece s IBD-om i procijeniti njihov učinak na: a) nutritivni status koristeći strogo definirane parametre, b) tijek bolesti. U istraživanje će se uključiti novodijagnosticirani bolesnici s IBD-om te zdrave kontrole.2. Crijevna mikroflora. Znanstveno je potvrđena terapijska učinkovitost isključive enteralne prehrane (EEN - exclusive enteral nutrition) na aktivnu formu Crohnove bolesti (CD) u djece, koja se, dijelom, pripisuje utjecaju na crijevnu mikrofloru. Međutim, dokaza o njihovoj povezanosti zasad nema. Stoga je drugi cilj ovog istraživanja utvrditi razliku u crijevnoj mikroflori u trenutku postavljanja dijagnoze i nakon indukcije remisije sa EEN. Crijevna mikroflora bolesnika usporedit će se s crijevnom mikroflorom zdravog brata ili sestre oboljelog djeteta i to neposredno prije, i dva dana nakon početka EEN. Nadalje, u djece s CD crijevna će se mikroflora odrediti i nakon završetka EEN te svakih dva mjeseca tijekom cijele prve godine praćenja. 3. PED-IBD registar. Do sada nije utvrđena incidencija, tijek i ishod bolesti („natural history“) u djece oboljele od IBD-a u Republici Hrvatskoj. Slijedom navedenoga, treći je cilj našeg projekta utemeljiti nacionalni registar djece s IBD-om s on-line bazom podataka koja će sadržavati sve važne kliničke i dijagnostičke parametre u sve djece s novodijagnosticiranom bolesti u Hrvatskoj. Podaci o bolesniku unositi će se kod dijagnoze i nakon godine dana praćenja. Za određivanje rizičnih čimbenika za nastanak relapsa koristit će se multivarijatna analiza koja će uključiti kliničke i terapijske parametre. ]]></summary_hr><summary_en><![CDATA[The etiology and pathogenesis of inflammatory bowel disease (IBD) have not been fully elucidated. 1. Diet. Patients with IBD, despite the absence of scientific evidence, often avoid certain types of food; however the effect of those self-imposed diets has not been determined. This is especially important in children whereby insufficient diet could have long-term consequences on growth and development. Therefore, the first objective of our study is to determine the frequency of self-induced diets in children with IBD and their impact on: a) nutritional status by using clearly defined parameters and b) course of the disease. The study will include newly diagnosed patients with IBD and healthy controls. 2. Intestinal microflora. It has been hypothesized that the excellent therapeutic effect of exclusive enteral nutrition (EEN) on pediatric active Crohn&#39;s disease (CD) could be explained by the effect on intestinal microflora. However, well performed studies are lacking. Therefore, the second objective of our study is to determine the difference in gut microflora at diagnosis and after remission induction achieved with EEN. Patients’ intestinal microflora will be compared with the microflora of healthy siblings before and two days after both groups receive EEN. Furthermore, in children with CD the intestinal microflora will be determined after 6 weeks of EEN and during the first year of follow up.  3. PED-IBD Registry. The incidence and natural history of pediatric IBD in Croatia has not been determined yet. The third goal of our project is to establish a national registry of children with IBD by providing an on-line database that will contain relevant clinical and diagnostic factors on all newly diagnosed pediatric IBD patients. To achieve this goal data will be entered at diagnosis and after one year of follow up. Multivariate analysis, which will include clinical and therapeutic parameters, will be used to determine risk factors for early disease relapse.]]></summary_en></project><project>
<id>3224</id><title_hr><![CDATA[Biomarkeri u shizofreniji – integracija komplementarnih prisutupa u praćenju osoba s prvom psihotičnom epizodom]]></title_hr><title_en><![CDATA[Biomarkers in schizophrenia – integration of complementary methods in longitudinal follow up of first episode psychosis patients ]]></title_en><user_id>5485</user_id><user_firstLast_name>Martina Rojnic Kuzman</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2014-09</proposal_call><code>UIP-2014-09-1245</code><acronim><![CDATA[BIS – LF FEP]]></acronim><duration>01.08.2015 - 31.03.2019</duration><status>Završio</status><financ_value>106.178,25 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Kliničke medicinske znanosti, </scie_field_hr><scie_field_en>Clinical sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb School of Medicine]]></institution_en><team_members_id>13000, 12759, 13269, 13311, 4713, 5007, 13330, 13208, 4369, 5787, 12762, 13342, 6334, 13515, 13496, 13313, 13510, 2549, 3483, </team_members_id><team_members_names><![CDATA[Zoran Madžarac, Ivana Kekin, Ratimir Petrović, Aleksandar Savić, Lana Ganoci, Nada Božina, Željka Vogrinc, Nina Mayer, Tamara Božina, Branko Malojčić, Dina Bošnjak, Marina Boban, Maja Živković, Daniel J. Mueller (Müller), Igor Filipcic, Vladimir Grošić, Marina Šagud, Ana Hladnik, Sanja Darmopil, ]]></team_members_names><keywords_hr><![CDATA[shizofrenije, prva epizoda, prospektivno praćenje, neuroimaging, farmakogenetika, post mortem]]></keywords_hr><keywords_en><![CDATA[schizophrenia, first episode; prospective follow up, neuroimaging, pharmacogenetics, post mortem]]></keywords_en><summary_hr><![CDATA[Shizofrenija je jedna od najtežih psihijatrijskih bolesti, koje pogađa oko 1% populacije. Iako su mnoga su istraživanja usmjerena potrazi biomarkera tijeka bolesti i liječenja, još nije utvrđen biološki pokazatelj shizofrenije. Stoga je potreba revizija dosadašnje  metodologije, uključujući:  1) prospektivna istraživanjima na dobro definiranom uzorku bolesnika s prvom psihotičnom epizodom (PPE) koja ne bi imala ograničenja dosadašnjih istraživanja (npr. transverzalni dizajn, heterogeni uzorak bolesnika, primjenu različitih lijekova); 2) integraciju više pristupa koji zajednički ukazuju na predispoziciju za shizofreniju. Rezultati genetičkih istraživanja upućuju da shizofrenija nastaje uslijed međuinterakcije gena i okoliša, ponovo revitalizirajući model stres dijateze u razvoju shizofrenije.Stoga planiramo istražiti set biomarkera prema tom modelu uključujući psihopatološki status, neurokognitivno funkcioniranje te odgovor na stres koristeći funkcionalne i neuroslikovne prikaze mozga (Single photon emission computed tomography - SPECT) u 150 PPE bolesnika. Istražit ćemo razlike potencijalnih biomarkera u odnosu na kontrole, te njihove promjene u psihozi i kasnijoj remisiji kroz 18-mjesečno prospektivno praćenje. Dobivene rezultate ćemo koristiti u procjeni povezanosti terapijskog odgovora i farmakogenetičkih biljega. Istraživanje cjelokupnog genoma (Genome wide association study - GWAS) ćemo provoditi u suradnji s istraživačkom grupom iz Toronta. Obzirom na rezultate dobivenih in-vivo funkcionalnih i imaging istraživanja učiniti ćemo analizu broja i distribucije, te morfoloških i kemijskih osobitosti specifičnih tipova neurona u histološki obrađenom kortikalnom tkivu iz post mortem uzoraka osoba sa shizofrenijom u odgovarajućim regijama mozga.Projekt je nastavak naših ranijih istraživanja, ali i uvodi novi multidisciplinarni pristup u okrivanju biomarkera u PPE. Rezultati ovog istraživanja će stoga doprinijeti znanstvenim spoznajama na internacionalnoj razini.]]></summary_hr><summary_en><![CDATA[Schizophrenia is one of the most disabling psychiatric illnesses, affecting about 1% of population worldwide. Efforts have been made to identify a biological correlate of schizophrenia yet without straightforward results. Thus, the methodology in the search of biomarkers has to be revised including: 1) longitudinal studies of first episode schizophrenia (FEP) patients, to overcome the confounders from previous studies (i.e. cross sectional design, heterogeneous sample of patients, confounding effects of medication); 2) integration of different approaches when searching for biomarkers. A large body of genetic studies concluded that schizophrenia results from the gene x environment interaction and once again revitalized the stress diathesis model of schizophrenia. Thus, we will examine a set of biomarkers according to this model including the psychopathological status, neurocognitive functioning and stress response by using brain functional and neuroimaging (single photon emission computed tomography - SPECT) methods in 150 FEP patients vs. controls and their changes during the FEP and subsequent remission in 18-month longitudinal follow up. Secondly, we will examine the course of treatment of previously unmedicated FEP patients by using pharmacogenetic analysis. Genome wide association studies (GWAS) will be performed in collaboration with the research group of Toronto, further expanding our international collaboration. We will study alteration in number and distribution, as well as morphology and chemical properties of specific neuron subclasses in histologically prepared human cortical tissue of schizophrenic subjects in the region that synaptic alteration was suggested by in-vivo functional and structural imaging (SPECT).This project is a continuation of our previous studies, but it also brings a innovative multidisciplinary approach to identify biomarkers in FEP. The results of this study will thus contribute to the scientific knowledge on international level.]]></summary_en></project><project>
<id>3230</id><title_hr><![CDATA[Optomehanika uzrokovana frekventnim češljem]]></title_hr><title_en><![CDATA[Frequency-comb-induced optomechanics]]></title_en><user_id>5410</user_id><user_firstLast_name>Ticijana Ban</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2014-09</proposal_call><code>IP-2014-09-7342</code><acronim><![CDATA[MeCombO]]></acronim><duration>01.09.2015 - 31.08.2019</duration><status>Završio</status><financ_value>131.315,95 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, </scie_field_hr><scie_field_en>Physics, </scie_field_en><institution_hr><![CDATA[Institut za fiziku]]></institution_hr><institution_en><![CDATA[Institute of Physics in Zagreb]]></institution_en><team_members_id>5742, 5029, 5776, 5617, 5890, 24455, 25234, 25432, </team_members_id><team_members_names><![CDATA[Aleksandra Foltynowicz, Damir Aumiler, Hrvoje Buljan, Piotr Maslowski, Roman Ciuryło, Ivor Krešić, Mateo Kruljac, Domagoj Kovačić, ]]></team_members_names><keywords_hr><![CDATA[optomehanika, frekventni češalj, optička šupljina, spektroskopija, koherencija, hladni atomi, rubidij, magneto-optička zamka (MOT), dipolna zamka]]></keywords_hr><keywords_en><![CDATA[optomechanics, frequency comb, optical cavity, spectroscopy, coherence, cold atoms,rubidium, magneto-optical trap (MOT), optical dipole trap]]></keywords_en><summary_hr><![CDATA[Sila na atome uzrokovana kontinuiranim (eng. continuous wave, cw) laserima predstavlja centralni dio istraživanja u području atomske fizike već zadnjih nekoliko desetljeća. Radijativna sila čini osnovu za lasersko hlađenje i zarobljavanje atoma, čime je omogućeno stvaranje dovoljno gustih i hladnih atomskih uzoraka. Ipak, unatoč opsežnom i dobro shvaćenom području optomehanike uzrokovane cw laserom, istraživanja sila na atome uslijed interakcije s nizom ultrakratkih pulseva (odnosno frekventnim češljem) su oskudna. U međuvremenu, rezultati istraživanja provedenih u našoj grupi ukazuju na to da se, u specifičnoj geometriji pobude atoma frekventnim češljem, javljaju posve novi fenomeni koji zahtjevaju dodatna eksperimentalna i teorijska istraživanja.  Cilj ovog projekta je istraživanje novih fenomena koji se javljaju uslijed dijelovanja sile na atome uzrokovane frekventnim češljem (FC), a uključuje fenomene sprezanja i dekoherencije, stvaranja dipolne zamke s fs laserima u blizini atomske rezonancije te hlađenje atoma u optičkoj šupljini (rezonatoru) uzrokovano FC-om. Predložena istraživanja otvorit će nekoliko intrigantnih tema u području istraživanja koje je relevantno znanstvenoj zajednici širom svijeta. Predloženi će projekt utjecati na podizanje prepoznatljivosti hrvatske znanosti u svijetu, zapošljavanje i usavršavanje mladih istraživača i jačanje kapaciteta Instituta za fiziku putem međunarodne suradnje.]]></summary_hr><summary_en><![CDATA[Inducing mechanical action on atoms by continuous wave (cw) laser excitation has been a central topic in atomic physics for decades. Yet, in contrast to the rich and fruitful field of cw-laser-induced optomechanics, the investigations of mechanical action on atoms due to interaction with trains of ultrashort laser pulses (i.e. frequency combs) are scarce in literature. Meanwhile, recent results made in our group have indicated that in a specific excitation geometry an entirely new type of FC-atom interaction emerges that calls out for further experimental and theoretical investigation.The aim of the project is to explore novel phenomena that arise when the mechanical action on cold atoms is induced by frequency comb (FC) excitation, including entanglement and decoherence, near-resonance dipole trap, and frequency-comb-induced cavity cooling. The proposed research will open up several intriguing topics in the field of research that is relevant to the scientific community worldwide.The proposed project will increase the visibility of Croatian science, employ and educate young researchers and strengthen the capacity of the Institute of Physics through international cooperation.]]></summary_en></project><project>
<id>3233</id><title_hr><![CDATA[Serotonergična modulacija pretilosti: međuovisnost regulatornih molekula i puteva]]></title_hr><title_en><![CDATA[Serotonergic modulation of obesity: cross-talk between regulatory molecules and pathways]]></title_en><user_id>5668</user_id><user_firstLast_name>Lipa Čičin-Šain</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2014-09</proposal_call><code>IP-2014-09-7827</code><acronim><![CDATA[SERT-OB]]></acronim><duration>01.09.2015 - 30.01.2020</duration><status>Završio</status><financ_value>124.241,82 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, Kliničke medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, Clinical sciences, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>12412, 519, 12665, 12368, 5996, 12354, 21389, </team_members_id><team_members_names><![CDATA[Darko Orešković, Jasminka Štefulj, Darko Kolarić, Gordana Mokrović, Maja Kesic, Marina Horvatiček, Petra Baković, ]]></team_members_names><keywords_hr><![CDATA[serotonin, pretilost, adipociti, hipotalamus, leptin, životinjski model]]></keywords_hr><keywords_en><![CDATA[serotonin, obesity, adipocytes, hypothalamus, leptin, animal model]]></keywords_en><summary_hr><![CDATA[Održavanje energetske ravnoteže organizma kompleksan je proces koji uključuje interakciju različitih centralnih i perifernih regulatornih molekula. Uloga neurotransmitera serotonina (5HT) u modulaciji unosa hrane odavno je poznata, no rezultati novijih istraživanja na životinjama sa genetički promijenjenim 5HT sustavom, u suprotnosti su sa pretpostavkom da veća bioraspoloživost 5HT dovodi do redukcije tjelesne težine, te traže bolje poznavanje integrativnih mehanizama regulacije energetske homeostaze.Ovim projektom se istražuje uloga individualne razine aktivnosti 5HT sustava u regulaciji unosa i potrošnje energije, korištenjem originalnog životinjskog modela (Wistar-Zagreb 5HT štakor), razvijenog u vlastitom laboratoriju selektivnim parenjem životinja prema aktivnosti perifernog 5HT transportera, ključnog proteina u regulaciji bioraspoloživosti 5HT. Dvije sublinije životinja, 5HT-visoka i 5HT-niska, dobivene genetičkom selekcijom, konstitucijski se razlikuju u homestazi centralnog i perifernog 5HT, što je pokazano neurokemijskim, farmakološkim i bihevioralnim studijama. Jedna od posljedica genetičke selekcije je i značajno povećana tjelesna težina životinja iz 5HT-visoke sublinije. Cilj projekta je otkriti biološku podlogu povezanosti povećane 5HT aktivnosti  i pretilosti kod hiperserotonergičnih životinja, te njezine funkcionalne posljedice. Istraživanja na molekularnoj razini fokusirana su na ekspresiju regulatornih peptida u hipotalamusu i adipocitima, njihove receptore i nizvodne signalne molekule, te transkripcijske faktore uključene u regulaciju adipogeneze i energetske homeostaze općenito. Istraživanja na razini organizma uključuju funkcionalni odgovor životinja na specifične fiziološke izazove - sklonost debljanju pri visoko kaloričnoj prehrani i sposobnost termogeneze pri izlaganju hladnoći.	Pored doprinosa temeljnom znanju u području neuroadipologije, ovaj projekt omogućiti će uspostavu novog životinjskog modela za istraživanje pretilosti.]]></summary_hr><summary_en><![CDATA[The rise in obesity has driven a major interest in the mechanisms maintaining energy homeostasis, a complex physiological process which includes interactions of various central and peripheral regulatory molecules. It is known that serotonin (5HT) - mediated mechanisms play a role in the pathophysiology of obesity, but results from recent studies utilizing genetic perturbations of the serotonin system are often at odds with the historical notion that increased 5HT bioavailability leads to body weight reduction, and highlight the need to better understand integrative mechanisms at work during lifelong alterations in 5HT signaling. This project is aimed to study the impact of constitutionally altered activity of 5HT system on the regulation of hypothalamic-adipose tissue axis that regulates energy balance. For this purpose we plan to use an original animal model, Wistar-Zagreb 5HT rats, developed in our laboratory by the use of selective breding toward extreme activities of peripheral 5HT transporter, a key regulator of 5HT bioavailability. As a result of genetic selection two sublines of the model, high-5HT and low-5HT subline, show constitutional differences in central and peripheral 5HT homeostasis. One of the consequences of genetic selection is also a markedly overweight phenotype of high-5HT animals. We will investigate biological basis of interplay between increased 5HT tone and adiposity in the hyperserotonergic subline, and their functional consequences.Studies at the molecular level will be focused on the expression of adipocyte- and hypothalamic-derived peptides, their receptors and downstream signaling as well as transcriptional factors and cofactors involved in the regulation of adipogenesis and energy homeostasis in general. Studies on the whole body level will include investigations of the functional responses of 5HT sublines to specific physiological challenges -  susceptibility to diet-induced obesity and capability for cold-induced thermogenesis. ]]></summary_en></project><project>
<id>3234</id><title_hr><![CDATA[Sudbina farmaceutika u okolišu i tijekom naprednih postupaka obrade vode]]></title_hr><title_en><![CDATA[Fate of pharmaceuticals in the environment and during advanced wastewater treatment]]></title_en><user_id>1414</user_id><user_firstLast_name>Sandra Babić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2014-09</proposal_call><code>IP-2014-09-2353</code><acronim><![CDATA[PharmaFate]]></acronim><duration>01.07.2015 - 30.06.2019</duration><status>Završio</status><financ_value>125.223,97 eur</financ_value><scie_area_hr>Prirodne znanosti, Tehničke znanosti, </scie_area_hr><scie_area_en>Natural sciences, Technological sciences, </scie_area_en><scie_field_hr>Kemija, Temeljne tehničke znanosti, </scie_field_hr><scie_field_en>Chemistry, Basic engineering sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet kemijskog inženjerstva i tehnologije]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Chemical Engineering and Technology]]></institution_en><team_members_id>4216, 900, 13246, 12861, 4391, 4498, 3680, 3775, 3971, 3926, 21142, 13643, </team_members_id><team_members_names><![CDATA[Danijela Ašperger, Lidija Ćurković, Marija Kaštelan-Macan, Davor Ljubas, Dragana Mutavdžić Pavlović, Martina Periša, Mira Petrovic, Irena Škorić, Dragana Vuk, Mirta Zrnčić, Dario Dabić, ĐURĐICA IVANEC ŠIPUŠIĆ, ]]></team_members_names><keywords_hr><![CDATA[farmaceutici, produkti razgradnje, okoliš,  napredni oksidacijski procesi, sol-gel TiO2 filmovi]]></keywords_hr><keywords_en><![CDATA[pharmaceuticals, degradation products, environment, advanced oxidation process, sol-gel TiO2 films]]></keywords_en><summary_hr><![CDATA[Znatan napredak analitičkih metoda u posljednjem desetljeću omogućio je utvrđivanje prisutnosti farmaceutika u svim sferama okoliša. Glavni izvor pojave i otpuštanja farmaceutika u okoliš su postrojenja za obradu otpadnih voda, što uvjetuje potrebu za njihovom nadogradnjom i implementacijom naprednih postupaka obrade voda poput naprednih oksidacijskih procesa (AOP).Kada farmaceutici dođu u okoliš neminovno su izloženi razgradnji. Razgradnja farmaceutika u okolišu ili razgradnja kao posljedica obrade otpadnih voda rezultira produktima sa značajno drugačijim fizikalno-kemijskim i toksičnim svojstvima u odnosu na početnu molekulu, a nerijetko su novonastali spojevi toksičniji od izvornih. Unatoč činjenici da je tisuće farmaceutika odobreno za uporabu, samo je mali postotak njih određivan u okolišu.Glavni ciljevi PharmaFate projekta su (i) razviti nove napredne postupke obrade otpadnih voda na temelju fotokemijskih AOP-a za učinkovito uklanjanje farmaceutika, te (ii) postići bolje razumijevanje sudbine farmaceutika u okolišu ispitivanjem njihove fotolize, hidrolize i sorpcije.U ovom projektu ispitivati će se farmaceutici koji se proizvode u velikim količinama, često se propisuju u medicinskoj praksi, potencijalno su postojani te skloni bioakumulaciji, a ne postoje podatci o njihovoj sudbini u okolišu.Predložene tehnologije obrade otpadnih voda uključuju napredne oksidacijske procese - fotolizu i heterogenu fotokatalizu uz primjenu nanokristaliničnih TiO2 filmova.Razjasnit će se mehanizmi razgradnje i identificirati razgradni produkti primjenom naprednih analitičkih metoda. U konačnici će se procijeniti toksičnost farmaceutika i njihovih razgradnih produkata.Očekivani doprinos projekta je u smislu znanstvenog istraživanja kroz stvaranje novih spoznaja koje će unaprijediti razumijevanje sudbine farmaceutika u okolišu i tijekom obrade voda te unapređenje tehnologija obrade voda čime se postiže socijalna dobrobit očuvanjem okoliša.]]></summary_hr><summary_en><![CDATA[The improvements of analytic methodologies during the last decades have demonstrated the widespread occurrence of pharmaceuticals (PhACs) in all environmental compartments. The main point of collection and subsequent release of PhACs into the environment are wastewater treatment plants (WWTPs), suggesting that their upgrade and implementation of AOPs are required. Once PhACs enter into the environment, partitioning and degradation occur. Degradation of PhACs in the environment or as a result of wastewater treatment can result in degradation products with significantly different physical, chemical and toxic properties even in formation of more toxic compounds. Despite the fact that thousands of PhACs are approved, only a small percentage of them have been studied for presence in the environment. The main objectives of the PharmaFate project are (i) to develop innovative advanced WWTPs based on photochemical AOPs for efficient removal of PhACs and (ii) to achieve an improved understanding of PhACs fate in the environment investigating their photolysis, hydrolysis and sorption.PhACs to be investigated are selected among those identified as high production volume and highly prescribed PhACs, potentially persistent and/or bioaccumulative with no or limited published data on their environmental fate. Proposed treatment technologies include AOPs – photolysis and heterogeneous photocatalysis using nanocrystalline TiO2 based thin films.Degradation mechanisms will be elucidated and degradation products will be identified using advanced analytical methods. Toxicity of PhACs and their degradation products will be assessed.Expected project impacts are in terms of scientific research through creation of new knowledge that will improve our understanding of PhACs fate in the environment and during wastewater treatment, technical improvement of WWTPs and social benefits by preserving the environment. ]]></summary_en></project><project>
<id>3238</id><title_hr><![CDATA[Dizajniranje, sinteza i evaluacija derivata primakina, vorinostata i sorafeniba kao potencijalnih citostatika]]></title_hr><title_en><![CDATA[Design, synthesis and evaluation of novel anticancer agents based on primaquine,  vorinostat and sorafenib scaffolds]]></title_en><user_id>6143</user_id><user_firstLast_name>Branka Zorc</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2014-09</proposal_call><code>IP-2014-09-1501</code><acronim><![CDATA[PVSderivatives]]></acronim><duration>01.12.2015 - 30.11.2019</duration><status>Završio</status><financ_value>98.838,68 eur</financ_value><scie_area_hr>Prirodne znanosti, Biomedicina i zdravstvo, </scie_area_hr><scie_area_en>Natural sciences, Biomedicine and health sciences, </scie_area_en><scie_field_hr>Farmacija, Kemija, </scie_field_hr><scie_field_en>Pharmaceutical sciences, Chemistry, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Farmaceutsko-biokemijski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Pharmacy and Biochemistry]]></institution_en><team_members_id>6183, 6538, 6615, 6707, 859, 13658, 21322, </team_members_id><team_members_names><![CDATA[Zrinka Rajić Džolić, Kristina Pavić, Dimitra Hadjipavlou-Litina, Eleni Pontiki, Katja Ester, Schols Dominique, Maja Beus, ]]></team_members_names><keywords_hr><![CDATA[sinteza, primakin, sorafenib, vorinostat, citostatik]]></keywords_hr><keywords_en><![CDATA[synthesis, primaquine, sorafenib, vorinostat, cytostatic]]></keywords_en><summary_hr><![CDATA[Dugoročni cilj projektnog prijedloga je razvoj novih bioaktivnih spojeva koji mogu dovesti do otkrića potencijalnih vodećih spojeva i antitumorskih lijekova. Projekt je usmjeren na dizajniranje, sintezu i biološko vrednovanje novih derivata primakina, vorinostata i sorafeniba. Primakin je antimalarik, dok su vorinostat i sorafenib citostatici.Potencijal da se novi citostatici razviju iz antimalarika postao je očit nakon otkrića da većina antimalarika djeluje citostatski, a čak sedam registriranih antimalarijskih lijekova nalazi se u kliničkim ispitivanjima kao potencijalni citostatici. Naša istraživačka skupina fokusirala se na primakin, antimalarik s kinolinskom strukturom. U nekoliko naših radova opisani su urea i semikarbazidni derivati primakina sa značajnim citostatskim djelovanjem i/ili velikom selektivnosti. Najveću selektivnost prema staničnim linijama MCF-7 i praktički neaktivnost prema ostalim staničnim linijama karcinoma pokazao je hibrid dviju primakin-urea. Na temelju tih rezultata predviđeno je dizajniranje, sinteza i evaluacija novih hibridnih molekula primakina kao potencijalnih citostatika. Prvo će se sintetizirati dvojni lijekovi primakina i vorinostata 3-8. Ti spojevi će se razlikovati po duljini alifatskog lanca i/ili funkcionalnim skupinama: spojevi opće formule 3 su esteri, 4 su karboksilne kiseline, a 6 hidroksamske kiseline kao i sam vorinostat. Potpunom ili djelomičnom redukcijom 4 priredit će se amini 7 i amidi 8. U ovom projektom prijedlogu predviđena je i sinteza amida primakina s derivatima cimetne kiseline 9 te analoga sorafeniba 14 s pirazinski prstenom, s pretpostavkom da će dodatni atom dušika pojačati vezne interakcije na aktivnom mjestu. Da bi odredili utjecaj supstituenata u amidnom ostatku na fizikalno-kemijska svojstva i jačinu djelovanja, planirana je modifikacija tog dijela molekule.Novi spojevi biti će biološki ispitani na citostatsko djelovanje, inhibiciju specifičnih enzima i antioksidativno djelovanje.]]></summary_hr><summary_en><![CDATA[The long-term goal of the proposed research is development of novel compounds with a potential for development to drug lead(s) and anticancer drug(s). The project will focus on rational design, synthesis and biological screening of novel derivatives of three marketed drugs: antimalarial primaquine and two antitumoral drugs vorinostat and sorafenib.The potential for discovery of new anticancer agents among antimalarials was first noted when commonly used antimalarials showed significant anticancer activity (7 of them have reached a clinical stage of development).  We have focused our attention to primaquine, the antimalarial agent with quinoline moiety. In our several papers novel urea and semicarbazide primaquine derivatives with strong antiproliferative activity and/or high selectivity were reported. The highest selectivity against MCF-7 cells and practically no activity against other tested cancer cell lines showed hybrid of two primaquine ureas. Based on these results we intend to design, synthesize and evaluate novel primaquine hybrid compounds as potential anticancer agents. First objective is to design and prepare novel twin drugs based on primaquine and vorinostat scaffolds 3-6. These compounds will differ in length of aliphatic chain and/or functional groups: compounds 3 are esters, 4 are carboxylic acids and 6 hydroxamic acids like vorinostat itself. Reduction of compounds 4 would generate amines 7 and amides 8. Further on, we plan to prepare primaquine amides 9 with substituted cinnamic acid and sorafenib analogs 14 based on pyrazine structure, hoping that additional nitrogen atom would increase the binding interactions. To study how the amide part of the molecule affects the activity and physico-chemical properties of the new pyrazine analogs, the preparation of a number of amides is planned.All new compounds will be screened for cytostatic activity in vitro on several human cancer cell lines, inhibition of specific enzymes and antioxidative activity.]]></summary_en></project><project>
<id>3240</id><title_hr><![CDATA[Izolacija, kvantifikacija i kinetika salivarnih Ap4A, SCCA i TROP2 kod pacijenata s oralnim karcinomom i potencijalno malignim poremećajima]]></title_hr><title_en><![CDATA[Isolation, quantification and kinetics of salivary Ap4A,  SCCA and TROP2 in patients with oral cancer and potentially malignant oral disorders]]></title_en><user_id>13132</user_id><user_firstLast_name>Darko Macan</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2014-09</proposal_call><code>IP-2014-09-9376</code><acronim><![CDATA[OC Sal TM]]></acronim><duration>01.05.2016 - 30.04.2019</duration><status>Završio</status><financ_value>55.965,28 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Dentalna medicina, Temeljne medicinske znanosti, Kliničke medicinske znanosti, </scie_field_hr><scie_field_en>Dental medicine, Basic Medical Sciences, Clinical sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Stomatološki fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Dentistry]]></institution_en><team_members_id>6958, 13181, 13213, </team_members_id><team_members_names><![CDATA[Ivan Salarić, Davor Brajdić, Ivan Zajc, ]]></team_members_names><keywords_hr><![CDATA[Rak usne šupljine, Tumorski markeri, Slina, Kromatografija, Tekućinska visokog učinka, Usna šupljina]]></keywords_hr><keywords_en><![CDATA[Oral cancer, Tumor Markers, Saliva, Chromatography, High Pressure Liquid, Mouth]]></keywords_en><summary_hr><![CDATA[Stanice oralnog karcinoma (OC) proizvode biokemijske substance, tumorske markere, u različitom omjeru  nego maligno neralterirane stanice, mjerljive u tkivima i/ili tjelesnim tekućinama.  Slina, radi svoje pristupačnosti, neposrednosti i neinvazivnog uzorkovanja, predstavlja idealno sredstvo za mjerenje tumorskih markera. Cilj ovog projektnog prijedloga jest izolirati, kvantificirati, objasniti ulogu i opisati kinetiku diadenozin tetrafosfata (Ap4a), „Squamous Cell Carcinoma povezanog antigena“ (SCCA), „Trophoblast cell surface antigena“ (TROP2) u zdravih pojedinaca te pacijanata s potencijalno malignim poremećajima (PMOD) i OC-om. Postoje brojna istraživanja na temu tumorskih markera OC-a, međutim, zadovoljavajuća specifičnost i senzitivnost još nije dosegnuta. Za izolaciju i kvantifikaciju gore navedenih markera razvit će se Liqiud chromatography-ion trap-mass spectrometry, Multiple Reaction Monitoring metoda (LC-IT-MS,MRM). Prema našim saznanjima, ova metoda dosad nije korištena za izolaciju i kvantifikaciju navedenih markera. Ap4a i TROP2 dosada nisu izolirani iz sline. Konačan cilj istraživanja jest razviti tumor-specifični test sa zadovoljavajućom senzitivnošću i specifičnošću te dinamički mjeriti markere, prije i nakon kirurškog zahvata, nakon radioterapije, nakon kemoterapije, jednu i dvije godine nakon inicijalne dijagnoze. Također, kao namjeravamo odrediti cirkadijalni ritam svakog pojedinačnog markera kako bi isključili potencijalne „confoundere“ kao što su utjecaj određene prehrambene namirnice ili pušenja ispitanika.  Tumor-specifični test OC-a, omogučio bi raniju dijagnozu OC-a, potencijalno i prije kliničkih simptoma, podizanje rate peto-godišnjeg preživljenja, omogučio raniju dijagnozu recidiva i/ili novih primarnih tumora te osigurao bolju kvalitetu života nakon liječenja. ]]></summary_hr><summary_en><![CDATA[Oral cancer (OC) tumor cells produce biochemical substances, tumor markers, differed from healthy individulals in expression or quantitative ratio, detectable in tissues and/or body fluids. Saliva, bacause of its accessibility, proximity and noninvasive approach, presents an ideal tool for the research of oral cancer tumor markers. The aim of this study will be to isolate, quantify, analyze the role and describe the kinetics of diadenosine tetraphophate (Ap4A), Squamous Cell Carcinoma associated Antigen (SCCA), Trophoblast cell surface antigen (TROP2) in patients with OC, potentially malignant disorders (PMOD) and age and sex matched control group with a clear medical history.There are number of studies published on OC tumor markers isolated mostly in serum, however the satisfactory specificity and sensitivity still hasn’t been reached. Liqiud chromatography-ion trap-mass spectrometry, Multiple Reaction Monitoring method (LC-IT-MS, MRM) will be developed to isolate and quantify the above mentioned tumor markers. To our knowledge, this method hasn&#39;t yet been used to quantify the above mentioned salivary tumor markers. Ap4A and TROP2 have never been isolated from saliva. Our goal is to develop a tumor-specific test with a satisfactory statistical sensitivity and specificity and dynamically measure the levels of tumor markers, before and immediately after therapy - surgery/radiotherapy/chemotherapy or their combination, and during regular follow-up one and two years after surgery. As another novelty, we will dtermine the markers circadian rhythm. A OC tumor specific test, with satisfactory sensitivity and specificity, would enable earlier OC diagnosis, possibly before the clinical appearance, raise the survival rate of OC patients, enable early diagnosis of recurrence and/or new primary tumors and ensure better post-treatment life-quality. ]]></summary_en></project><project>
<id>3248</id><title_hr><![CDATA[Uspostavljanje međukulturnih poveznica kroz prijevode dječje književnosti: tekst, kontekst, strategije]]></title_hr><title_en><![CDATA[Building Intercultural Bridges through Children’s Literature Translations: Texts, Contexts and Strategies]]></title_en><user_id>4856</user_id><user_firstLast_name>Smiljana Narančić Kovač </user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2014-09</proposal_call><code>UIP-2014-09-9823</code><acronim><![CDATA[BIBRICH]]></acronim><duration>01.09.2015 - 31.08.2018</duration><status>Završio</status><financ_value>57.442,43 eur</financ_value><scie_area_hr>Humanističke znanosti, Društvene znanosti, </scie_area_hr><scie_area_en>Humanities, Social sciences, </scie_area_en><scie_field_hr>Filologija, Obrazovne znanosti, </scie_field_hr><scie_field_en>Philology, Educational sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Učiteljski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Teacher Education]]></institution_en><team_members_id>5533, 2998, 5121, 5469, 4987, 5328, 5970, 5081, 13123, 18943, </team_members_id><team_members_names><![CDATA[Berislav Majhut, Tihomir Engler, Katarina Aladrović Slovaček, Sanja Lovrić Kralj, Ivana Milković, Corinna Jerkin, Snježana Veselica-Majhut, Marija Andraka, Iris Šmidt Pelajić, Nada Kujundžić, ]]></team_members_names><keywords_hr><![CDATA[hrvatska dječja književnost, prijevodne strategije, pripovjedna proza, 20. stoljeće, međukulturni prijenos, kanon, diskurs, ukriženi tekst]]></keywords_hr><keywords_en><![CDATA[Croatian children&#39;s literature, translation strategies, narrative fiction, 20th century, intercultural transfer, canon, discourse, crossover text]]></keywords_en><summary_hr><![CDATA[Cilj je predloženoga projekta prikazati i objasniti ulogu i status prevedenih djela u korpusu hrvatske dječje književnosti, opisati trendove i tendencije u povijesnoj perspektivi te otkriti i protumačiti upotrijebljene prijevodne strategije. Projekt je usmjeren na prijevode pripovjedne proze na hrvatski i iz hrvatskoga na druge jezike tijekom dvadesetoga stoljeća.Međunarodna istraživanja dječje književnosti u novije se vrijeme u znatnoj mjeri okreću k poredbenoj dječjoj književnosti, fokusirajući se na analizu prijevoda, međukulturni prijenos i kontakte među jezicima i kulturama. U tome se podudaraju s prijevodnim studijima u širem smislu. Nakana je uspostaviti skupinu istraživača koja bi razvila takvo područje istraživanja u hrvatskome kontekstu, i koja će postaviti istraživačke standarde i prilagoditi primjerenu metodologiju specifičnostima opisanoga predmeta istraživanja.U planu je sastavljanje bibliografije prijevoda dječjih knjiga i ukriženih tekstova (crossover texts), tj. djela ujedno namijenjenih dječjem i odraslom čitateljstvu. Podatci će se analizirati i tumačiti s obzirom na polazišne i posredne jezike pojedinih prijevoda, povijesne trendove, izbor knjiga u odnosu na kanon dječje književnosti, nakladničke prakse i druge aspekte. Nadalje, odabrani primjeri prijevoda analizirat će se kako bi se utvrdile prijevodne strategije na različitim razinama diskursa. Razmotriti će se jezični, pripovjedni, kulturni i međukulturni aspekti s ciljem otkrivanja prijevodnih normi i strategija odomaćivanja (domestikacije). Hrvatskim će se djelima prevedenima na druge jezike posvetiti posebna pozornost.Rezultati će se analizirati i interpretirati kako bi se objasnile prijevodne tendencije, trendovi i dinamika književnih suodnosa tijekom dvadesetoga stoljeća iz hrvatske perspektive, kao i u međunarodnome kontekstu.Predloženi će projekt pripremiti temelj za dalji razvoj opisanoga područja istraživanja i za buduću širu međunarodnu suradnju.   ]]></summary_hr><summary_en><![CDATA[The proposed project aims to depict and explain the role and status of translated books within Croatian children’s literature, to describe trends and tendencies in a historical perspective, and to establish and interpret adopted translation strategies. The project focuses on translations of narrative fiction into and from Croatian over a span of a hundred years, i.e. in the 20th century. International scholarship in the field of children’s literature has recently turned towards comparative children’s literature, focusing on translation, intercultural transfer and contacts among languages and cultures. In so doing, it intersects with recent trends in translation studies in general. The proposed project aims to establish a team of researchers who would develop such an area of research in Croatia. The goal is to set research standards and fine-tune appropriate methodology.The researchers intend to assemble a bibliography of translated children’s books and crossover texts. Records will be analysed and interpreted with respect to the source and intermediary languages represented, historical trends, book selection relative to the canon of children’s literature, publishing practices and other aspects. Next, a selection of published books will be analysed for translation strategies at several levels of discourse. The researchers will address linguistic, narrative, cultural and intercultural aspects, and focus on uncovering translation norms and domestication strategies. Croatian books translated into other languages will receive special attention.Finally, the results will be analysed and interpreted to explain the documented translation flows, trends, and the dynamics of literary relationships in the 20th century, from the Croatian perspective and in the international context. The proposed project will present a sound foundation for further development of the established area of research and of a wider international cooperation in the future. ]]></summary_en></project><project>
<id>3251</id><title_hr><![CDATA[Električko nabijanje međupovršina na granici čvrsta faza/vodena otopina elektrolita]]></title_hr><title_en><![CDATA[Electrical charging of solid/aqueous electrolyte interfaces]]></title_en><user_id>244</user_id><user_firstLast_name>Tajana Preočanin</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2014-09</proposal_call><code>IP-2014-09-6972</code><acronim><![CDATA[SAQUINT]]></acronim><duration>01.06.2015 - 31.05.2019</duration><status>Završio</status><financ_value>114.539,78 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, </scie_field_hr><scie_field_en>Chemistry, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>836, 4764, 4782, 1015, 234, 5334, 22756, 24520, </team_members_id><team_members_names><![CDATA[Danijel Namjesnik, Damir Iveković, Sandra Čičić, Jasmina Salopek, Davor Kovačević, Josip Požar, Antun Barisic, Tin Klačić, ]]></team_members_names><keywords_hr><![CDATA[električni međupovršinski sloj, površinske reakcije, površinski potencijal, metalni oksidi, polielektroliti, višeslojevi, kompleksiranje, nanočestice ]]></keywords_hr><keywords_en><![CDATA[electrical interfatial layer, surface reaction, surface potential, metal oxide, polyelectrolyites,multilayers, complexation, nanoparticles]]></keywords_en><summary_hr><![CDATA[Cilj je predloženog projekta istražiti procese koji se zbivaju na međupovršini čvrsta tvar/tekućina u svrhu boljeg razumijevanja interakcije površine mineralnih faza s molekulama vode, otopljenim ionima i složenim makromolekulama. Nove eksperimentalne metode omogućavaju karakterizaciju pojedinih kristalnih ploha te će se ispitati utjecaj strukture površine na nastajanje električkog međupovršinskog sloja. Za određivanje površinskog potencijala na 0-plohi pojedinih kristalnih ploha koristit će se monokristalne elektrode koje su po prvi put konstruirane u našem laboratoriju. Naime, upravo površinski potencijal na 0-plohi definira broj i vrstu površinskih specija na određenoj plohi, a time i ravnotežno stanje. Kombiniranjem podataka dobivenim mjerenjem površinskog potencijala na 0-plohi i elektrokinetičkog potencijala nastojat će se objasniti ravnotežni procesi koji se zbivaju na granici faza. Zanimljivu klasu površinskih reakcija čine procesi uzastopne naizmjenične adsorpcije polielektrolita suprotnog naboja na okside metala i polumetala. Navedeni procesi bit će istraženi u sklopu predloženog projekta. Dobiveni rezultati će se usporediti s rezultatima kompleksiranja polielektrolita u otopini. Naglasak u istraživanju bit će na specifičnom utjecaju protuiona na reakcije dvaju suprotno nabijenih polielektrolita. U konačnici rezultati dobiveni za pojedine plohe će se primijeniti na koloidne i nano čestice čija se površina sastoji od različitih kristalnih ploha. Interes za istraživanjem spomenutih nanostruktura i polielektrolita povezan je sa brojnim mogućnostima njihove primjene u industriji, odnosno razumijevanju uloge prirodnih polielektrolita i proteina u biološkim procesima. U svrhu izvođenja projekta koristit će se različite eksperimentalne metode, a za bolje razumijevanje procesa koje se zbivaju na međupovršinama i dobivanja kvantitativnog opisa specijacije svih vrsta koje sudjeluju u površinskim reakcijama, bit će razvijeni i odgovarajući teorijski modeli.]]></summary_hr><summary_en><![CDATA[In order to contribute to the understanding of basic interactions between the mineral phases and water molecules, ions and macromolecules we propose the investigations of processes at solid/liquid interfaces. Particular attention will be paid on a role of water, simple counterions and surface structure in formation of electrical interfacial layer. The single crystal electrode, device developed and constructed recently in our laboratory, will be used for determination of inner surface potential of specific crystal planes. Inner surface potential affects directly the state of ionic species bound to defined surface plane and is thus essential parameter governing interfacial equilibrium. The role of interfacial water in interfacial equilibrium will be analyzed by considering its behavior at inert surfaces but also at metal oxide surfaces. Finally, the results obtained for the particular crystal planes will be applied for colloids and nanoparticles exhibiting different crystal planes to the liquid medium. A special case of interfaces are polyelectrolytes at the metal oxide surface. Therefore, such interfaces and their correlation with the behaviour of polyelectrolytes in solution will be also extensively studied in the frame of the proposed project. The reason lies in fundamental interest to understand their properties in relation with the role of natural polyelectrolytes and proteins in biological processes, as well as in industrial applications. The latter are not limited to polyelectrolytes in solution, but include also the polyelectrolyte (or interpolyelectrolyte) complexes and multilayers. The formation of multilayers of polyelectrolytes at solid surfaces, as well as interpolyelectrolyte interactions in solution, will be examined. Special emphasis will be given on specific ionic effects. Predominantly the experimental methods will be applied, and theoretical tools will be developed in order to better understand behavior, reactivity and equilibrium at interfaces.]]></summary_en></project><project>
<id>3265</id><title_hr><![CDATA[Električni transport u staklima i staklo-keramici]]></title_hr><title_en><![CDATA[Electrical transport in glasses and glass-ceramics]]></title_en><user_id>4869</user_id><user_firstLast_name>Andrea Moguš-Milanković</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2014-09</proposal_call><code>IP-2014-09-5863</code><acronim><![CDATA[EL-Trass-Ceram]]></acronim><duration>15.06.2015 - 14.06.2018</duration><status>Završio</status><financ_value>99.542,11 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, </scie_field_hr><scie_field_en>Chemistry, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>3297, 3302, 3421, 13648, 13669, 13670, 21288, </team_members_id><team_members_names><![CDATA[Ana Šantić, Kristina  Sklepić, Luka Pavić, Grégory TRICOT, Petr Mosner, Ladislav Koudelka, Juraj Nikolić, ]]></team_members_names><keywords_hr><![CDATA[Električni prijenos, staklo, staklo-keramika, elektronsko-ionska vodljivost, efekt &#39;&#39;miješanih&#39;&#39; staklotvoraca]]></keywords_hr><keywords_en><![CDATA[Electrical transport, glass, glass-ceramics, mixed ionic-electronic conductivity, mixed glass former effect]]></keywords_en><summary_hr><![CDATA[Izraženi zahtjevi suvremenih tehnologija za novim materijalima sa specifičnim svojstvima otvaraju velike mogućnosti u istraživanju stakala i staklo-keramike. Priprava novih stakala i staklo-keramika posebnih svojstava, istraživanje odnosa sastava stakla, strukture, električnih i termičkih svojstava posebno je važno za razumijevanje procesa koji se odvijaju u tim materijalima. Cilj je predloženog istraživanja priprava novih više-komponentnih fosfatnih stakala te određivanje odnosa između dvije osnovne vrste nositelja naboja, iona i elektrona, prisutnih u odabranim staklima i staklo-keramikama. Predloženi je projekt podijeljen na tri osnovna, međusobno povezana, koraka. 1. U prvom će se dijelu istraživati mehanizmi vodljivosti u fosfatnim staklima koja pokazuju „miješanu“ elektronsko-ionsku vodljivost. 2. Drugi dio uključuje istraživanje utjecaja „miješanih“ staklotvoraca na električne procese kod fosfatnih stakala.  3. U trećem će se dijelu istraživati utjecaj kontrolirane kristalizacije na električni prijenos u odabranim modelnim sustavima iz koraka 1 i 2. Nastajanje kristalnih zrna u staklenoj matrici može promijeniti električnu vodljivost i dielektična svojstva stakla. Temeljna je ideja projekta sustavno istraživanje koje će pridonijeti razumijevanju dinamike prijenosa naboja (iona i elektrona) u staklima i staklo-keramici s različitim udjelom kristalnosti (od potpuno amorfnih do potpuno kristaliziranih). Osnovni je cilj odrediti pokazuju li uvijek ionsko-elektronska stakla i stakla koja sadrže više staklotvoraca, efekt ionsko-elektronske vodljivosti odnosno efekt „miješanih“ staklotvoraca što predstavlja univerzalno obilježje.  Međudjelovanje staklotvoraca i modifikatora mreže te nastajanje veza među njima osnovni su čimbenici koji utječu na električna svojstva stakala. Osim što je istraživanje mehanizama vodljivosti u odabranim sustavima važno s akademskog gledišta, odabrani sustavi pokazuju široke mogućnosti u primjeni kao novi elektroliti.]]></summary_hr><summary_en><![CDATA[Considerable demands of modern technology for new materials with specific properties have raised many possibilities for the investigation of glasses and glass-ceramics. Preparation of new glass and glass-ceramics with characteristic properties and the investigation of relationships among compositions, structure, electrical and thermal properties are important for understanding the mechanisms involved in these materials. The objectives of the proposed research is to prepare novel multi-compositional phosphate-based glasses, determine the correlation among both types of charge carriers, ions and electrons, present in proposed systems. In order to accomplish this, the proposed project is divided into three main interrelated steps. 1. First part will be focused on the conduction mechanisms in phosphate-based glasses that exhibit mixed electronic-ionic conduction. 2. Second part includes study of the influence of the mixed glass former effect on electrical processes in phosphate-based glasses. 3. Third part involves study of the influence of controlled crystallization on electrical transport in selected model glasses from steps 1 and 2. The formation of crystalline grains  in a glass matrix can substantially change electrical conductivity and dielectric properties of glass. The idea is to perform systematic studies for understanding the charge transport (ion and electron) dynamics in glasses and glass-ceramics with different crystallinity (from fully amorphous to fully crystallized). The main aim is to determine the universality of the mixed electronic-ionic and mixed glass former effects in proposed glasses. The interactions between glass formers and modifiers, the formation of bonds among them are essential factors that influence the electrical properties of glasses. Beyond the connection to the central theme of conduction mechanism important from academic point of view, the selected systems are all associated with their multiple applications as advanced electrolytes.]]></summary_en></project><project>
<id>3266</id><title_hr><![CDATA[Akrobacije molekulskih kristala - termoodskočni materijali za novu generaciju aktuatora]]></title_hr><title_en><![CDATA[Acrobatics of molecular crystals – thermosalient materials for new generation of actuators]]></title_en><user_id>13189</user_id><user_firstLast_name>Željko Skoko</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2014-09</proposal_call><code>IP-2014-09-7506</code><acronim><![CDATA[AKROBATOO MATER]]></acronim><duration>01.07.2015 - 30.06.2018</duration><status>Završio</status><financ_value>93.512,51 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, Kemija, </scie_field_hr><scie_field_en>Physics, Chemistry, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>12971, 13347, 4933, </team_members_id><team_members_names><![CDATA[Lidija Androš, Pance Naumov, Vito Despoja, ]]></team_members_names><keywords_hr><![CDATA[termoodskočni efekt, aktuatori, strukturna analiza, rendgenska difrakcija, kvantnomehaničko modeliranje]]></keywords_hr><keywords_en><![CDATA[thermosalient effect, actuators, structure analysis, XRD, DFT calculations]]></keywords_en><summary_hr><![CDATA[Ciljano dizajniranje novih aktuatorskih materijala, koji su u stanju pružiti odgovor na vanjsku pobudu (toplinsku ili svjetlosnu) u obliku brzog, revezibilnog i kontroliranog mehaničkog kretanja trenutno predvodi istraživanja u znanosti o materijalima. Među takvim materijalima, nekoliko slučajno otkrivenih primjera kristala koji skaču za vrijeme grijanja, do daljina nekoliko tisuća puta većih od njihovih dimenzija u vremenu kraćem od 1 ms, pružaju impresivan prikaz pretvorbe toplinske energije u mehanički rad. Takvi termoodskočni (eng. thermosalient) kristali su biomimetički, nepolimerni samo-aktuatori par excellance. Ipak, zbog ekskluzivnosti ovog fenomena, i također zbog izuzetne složenosti analitičke metodologije za njegovu karakterizaciju, razlozi koji izazivaju ovu kolosalnu samo-aktuaciju ostaju nerazjašnjeni. Unutar projekta, odredit će se razlog postojanja termoodskočnog efekta u odabranim sustavima organskih molekulskih kristala (trans, trans, anti, trans, trans perhidropiren, L-piroglutamska kiselina te N’-2-propiliden-4-hidroski-benzohidrazid) koji su već poznati u literaturi, ali su još nerazjašnjeni. Nadalje, istraživanja će se proširiti na skupinu spojeva dobivenu odabranim i pažljivim modificiranjem spojeva za koje je efekt prethodno ustanovljen. Za očekivati je da će termoodskočni efekt biti izuzetno osjetljiv na suptilne promjene u kemijskom sastavu stoga će se omogućiti određivanje uvjeta za modeliranje novih materijala s termoodskočnim svojstvima. S ciljem elucidacije termoodskočnog fenomena, ovaj projekt predstavlja prvi sustavni pokušaj određivanje međuigre između termodinamičkih, kinematičkih, strukturnih i makroskopskih faktora termoodskočnog efekta pomoću difrakcijskih (XRD), mikroskopskih (hot-stage), spektroskopskih (FTIR, UV/VIS) i termičkih (DTA/DSC/TG) tehnika. Ispitivani sustavi također će se izučavati kvantomehaničkim modeliranjem (DFT). ]]></summary_hr><summary_en><![CDATA[Targeted design of new actuating materials which are capable of fast, reversible and controllable mechanical motion in response to external stimuli (thermal or light) is at the frontier of the contemporary materials science research. Among these, the few serendipitously discovered examples of crystals that suddenly jump while heated, to distances several thousand times larger than their own dimension in less than 1 ms, provide the most impressive display of the conversion of thermal energy into mechanical work. These thermosalient crystals are biomimetic, nonpolymeric self-actuators par excellence. Yet, due to exclusivity of the phenomenon, but also due to the complexity of analytical methods for its characterization, reasons behind this colossal self-actuation remain unexplained. Within this project, reasons behind the thermosalient effect in chosen systems of organic molecular crystals (trans,trans,anti,trans,trans perhydropyrene, L-pyroglutamic acid and N&#39;-2-propylidene-4-hydroxy-benzohydrazide), already reported in the literature – but unexplained, will be revealed. Furthermore, research will broaden to include a group of compounds obtained by careful and planned modification of the compounds in which the effect has already been observed. It is to be expected that the thermosalient effect is very sensitive to the subtle changes in the chemical composition so this will enable determination of necessary chemical/structural parameters so as to arouse the thermosalient effect in the system. With the aim of final elucidation of the thermosalient phenomenon, this project represents first systematic attempt to disentangle the interplay between the thermodynamic, kinematic, structural and macroscopic factors that drive the thermosalient effect by employing various diffraction (XRD), microscopic (hot stage), spectroscopic, (FTIR, UV/VIS) and thermal (DTA/DSC/TG) techniques. Systems under study will also be investigated by the means of quantomechanical modeling (DFT). ]]></summary_en></project><project>
<id>3277</id><title_hr><![CDATA[Prirodno stanište klinički značajnih Acinetobacter baumannii]]></title_hr><title_en><![CDATA[Natural habitat of clinically important Acinetobacter baumannii]]></title_en><user_id>419</user_id><user_firstLast_name>Jasna Hrenović</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2014-09</proposal_call><code>IP-2014-09-5656</code><acronim><![CDATA[NATURACI]]></acronim><duration>01.09.2015 - 31.10.2019</duration><status>Završio</status><financ_value>132.617,96 eur</financ_value><scie_area_hr>Prirodne znanosti, Biomedicina i zdravstvo, Biotehničke znanosti, Tehničke znanosti, </scie_area_hr><scie_area_en>Natural sciences, Biomedicine and health sciences, Biotechnical sciences, Technological sciences, </scie_area_en><scie_field_hr>Javno zdravstvo i zdravstvena zaštita, Geologija, Kemija, Biologija, Kemijsko inženjerstvo, Kliničke medicinske znanosti, Biotehnologija, </scie_field_hr><scie_field_en>Public health and health services, Geology, Chemistry, Biology, Chemical engineering, Clinical sciences, Biotechnology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>405, 1404, 12655, 586, 2669, 749, 565, 486, 18952, </team_members_id><team_members_names><![CDATA[Tomislav Ivanković, Darko Tibljaš, Marin Ganjto, Ivana Goić Barišić, Goran Durn, Ana Kovačić, Nevenka Rajić, Jelena Milenkovic, BLAŽENKA  HUNJAK, ]]></team_members_names><keywords_hr><![CDATA[Acinetobacter baumannii, Bakterije, Ekologija, Otpadna voda, Remedijacija, Tlo, Zeoliti]]></keywords_hr><keywords_en><![CDATA[Acinetobacter baumannii, Bacteria, Ecology, Remediation, Soli, Wastewater, Zeolites]]></keywords_en><summary_hr><![CDATA[Bakterija Acinetobacter baumannii je oportunistički patogen odgovoran za bolničke infekcije u imunokompromitiranih bolesnika, čija pojavnost dramatično raste tijekom zadnjeg desetljeća u Hrvatskoj i svijetu. Infekcije bakterijom A. baumannii se teško liječe zbog njihovih brojnih urođenih i stečenih mehanizama odgovornih za višestruku antibiotsku rezistenciju (multidrug-resistance; MDR), sposobnosti stvaranja biofilma, te dugotrajnog preživljavanja u bolnicama. Smatra se da su epidemije infekcija bakterijom A. baumannii uzrokovane isključivo kontaminacijom i prijenosom u bolničkom okruženju. MDR A. baumannii su nađene u bolničkim otpadnim vodama, ali ovakvi podaci nedostaju u Hrvatskoj. Do danas nije definirana pojavnost klinički važnih Acinetobacter spp. u prirodi niti njihov potencijal da prelaze u i/ili iz bolničkog okruženja. Potrebno je definirati prirodno stanište klinički važnih MDR A. baumannii. Postoji potreba za širim praćenjem te epidemiološkim studijama istraživanja utjecaja ljudskog otpada na rasprostranjivanje MDR A. baumannii. Cilj predloženog projekta je izolirati vijabilne MDR A. baumannii iz okolišnih uzoraka otpadne vode i tla. Okolišni izolati bit će genotipizirani te će biti određena njihova filogenetska srodnost s ljudskim izolatima kao i geni odgovorni za njihovu antibiotsku rezistenciju. Bit će određen i utjecaj ekoloških čimbenika na preživljavanje okolišnih izolata A. baumannii. Nadalje, istražit će se međudjelovanje okolišnih izolata A. baumannii i zeolita kao okolišno prihvatljivih dezinficijensa. Bit će razvijene metode i alternativni dezinficijensi na bazi prirodnih materijala za remedijaciju otpadnih voda i tla koja sadrže A. baumannii. Rezultati predloženog projekta će definirati prirodno stanište A. baumannii, te predložiti načine za smanjenje njihovog broja u zagađenom okolišu.]]></summary_hr><summary_en><![CDATA[Acinetobacter baumannii is an opportunistic pathogen responsible for nosocomial infections in immunocompromised patients, which emergence in hospital acquired infections increase dramatically over the last decade, both in Croatia and worldwide. Infections with A. baumannii are difficult to treat due to its ability to express multiple intrinsic and acquired mechanisms responsible for multidrug-resistance (MDR) to antibiotics, biofilm formation, and long-term persistence in hospitals. Outbreaks of A. baumannii infections are considered to be caused exclusively by contamination and transmission in hospital environment. MDR A. baumannii were detected in hospital wastewater, but such data are lacking in Croatia. The prevalence of clinically important Acinetobacter spp. in nature and their potential to migrate into and/or out of the hospital environments are undefined to date. The natural habitats of clinically important MDR A. baumannii remain to be defined. Larger screening and epidemiological studies should be performed to investigate the impact of human waste on the spread of MDR A. baumannii. The objective of the proposed project is to isolate viable MDR A. baumannii from the environmental samples of wastewater and soils. The environmental isolates will be genotyped and their phylogenetic relation to human isolates will be determined, as well as the profiles and genes responsible for their antibiotic resistance. The influence of ecological factors on the survival of environmental isolates of A. baumannii will be investigated. Interaction of environmental isolates of A. baumannii and zeolites as environmental friendly disinfectants will be studied. Methods and alternative disinfectants based on natural materials for the remediation of wastewater and soils containing A. baumannii will be developed. The findings of the proposed project will define the natural habitat of A. baumannii, and propose ways to reduce their numbers in contaminated environment.]]></summary_en></project><project>
<id>3286</id><title_hr><![CDATA[Komparativna i funkcionalna genomika fitoplazmi– emergentnih biljnih patogena u Hrvatskoj]]></title_hr><title_en><![CDATA[Comparative and functional genomics of phytoplasmas–emerging plant pathogens in Croatia ]]></title_en><user_id>12617</user_id><user_firstLast_name>Martina Šeruga Musić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2014-09</proposal_call><code>UIP-2014-09-9744</code><acronim><![CDATA[GenoPhyto]]></acronim><duration>01.07.2015 - 31.10.2018</duration><status>Završio</status><financ_value>73.992,97 eur</financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Poljoprivreda, Biotehnologija, </scie_field_hr><scie_field_en>Agriculture, Biotechnology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>11295, 12676, 12691, 12712, 12835, 13554, </team_members_id><team_members_names><![CDATA[Dijana Škorić, Foissac Xavier, Ivana Križanac, Jelena Plavec, Željko Budinšćak, Saskia Hogenhout, ]]></team_members_names><keywords_hr><![CDATA[bakterije, epidemiologija, dijagnostika, patogenost, filogenomika]]></keywords_hr><keywords_en><![CDATA[bacteria, epidemiology, diagnostics, pathogenicity, phylogenomics]]></keywords_en><summary_hr><![CDATA[Fitoplazme (rod ‘Candidatus Phytoplasma’) su bakterije bez stanične stijenke razreda Mollicutes - uzročnici značajnih bolesti biljaka u čitavom svijetu. Složenog su i jedinstvenog životnog ciklusa jer parazitiraju unutar stanica biljnog floema kao i stanica kukaca i trebaju oba domaćina za rasprostranjivanje u prirodi. Imaju male genome bogate ponavljajućim sljedovima reducirane u osnovnim metaboličkim putovima. Nije ih moguće uzgojiti u čistoj kulturi in vitro. Unatoč tome, do sada su sekvencirana 4 fitoplazmatska genoma uz nekolicinu nepotpunih. Era genomike donijela je značajna saznanja o funkcioniranju fitoplazmi no mehanizmi patogenosti još nisu razjašnjeni. Prisutnost fitoplazmi u Hrvatskoj dokazana je na simptomatičnim trsovima vinove loze krajem 90.-tih. Broj novih fitoplazmatskih vrsta, kukaca-vektora kao i ugroženih biljnih vrsta i dalje raste, s najbolje karakteriziranim patosistemima na vinovoj lozi i voćkama. Glavni cilj ovog projekta je sekvenciranje fitoplazme ‘Ca. P. solani’, najrasprostranjenije u Hrvatskoj, te generiranje i analiza nacrta ili potpuno sastavljenog genoma. Dobiveni rezultati ukazali bi na potencijalne efektore - faktore virulencije te druge molekule uključene u interakcije s domaćinima i prilagodbe okolišnim uvjetima. Nadalje, bili bi genotipizirani novi i već dostupni izolati MLST (multilocus sequence typing) analizom konstitutivnih te specifičnih varijabilnih gena. Zadaća projekta je i razvoj novog oruđa za genotipizaciju sa svrhom poboljšane dijagnostike i izrade molekularno-epidemioloških studija. Funkcionalne studije bile bi usmjerene na varijabilne membranske proteine odgovorne za interakcije s kukcima-vektorima. Ovo bi bio prvi projekt sekvenciranja nekog genoma bakterijskog patogena u Hrvatskoj. Ovim uspostavnim projektom i osnivanjem istraživačke grupe otvorilo bi se novo područje molekularne biljne patologije i genomike, slabo zastupljeno u hrvatskoj znanosti, a dobiveni rezultati postavili bi osnove za buduća istraživanja.]]></summary_hr><summary_en><![CDATA[Phytoplasmas (genus &#39;Candidatus Phytoplasma&#39;) are wall-less bacteria from the class Mollicutes that affect numerous plant species worldwide causing significant economic losses. They have a unique life-style inhabiting plant phloem and insect cells and needing both hosts for survival in nature. Their genomes are repeat-rich yet relatively small and reduced missing many basic metabolic pathways. Phytoplasma axenic cultivation is still challenging. Nevertheless, 4 phytoplasma genomes have been sequenced and annotated with several genome drafts also available. However, the understanding of all mechanisms underlying phytoplasma pathogenicity is far from complete. First molecular evidence for the phytoplasma presence in Croatia has been given in late 1990’s on grapevine. Since then, the number of discovered phytoplasma species, insect vectors and affected plant hosts is rising with grapevine and fruit trees’ phytoplasma pathosystems being well characterized. The main objective of this project would be sequencing of ‘Ca. P. solani’, the most widespread phytoplasma in Croatia, with generation and comparative analysis of genome draft or fully assembled genome. Obtained results would give new data on candidate virulence effectors and other factors involved in interactions with hosts and adaptation to different environments. Another goal would be genotyping of new and already available isolates by multilocus sequence typing (MLST) analyses of house-keeping and specific variable genes. New genotyping tools for improved diagnostics and molecular epidemiology studies with implications in risk assessment would also be developed. Functional studies would focus on surface variable membrane proteins involved in interactions with insect hosts and transmissibility. Moreover, this would be the first sequencing project of a bacterial plant pathogen genome in Croatia. The establishment of this project would open a new field of molecular plant pathology and genomics in Croatian science.]]></summary_en></project><project>
<id>3288</id><title_hr><![CDATA[poremećena vazorelaksacija i endotelno-leukocitna interakcija (ELI) u razvoju aterosklerotskih lezija]]></title_hr><title_en><![CDATA[Impaired Vasorelaxation and Endothelial-Leukocyte Interaction (ELI) in Development of Atherosclerotic Lesions]]></title_en><user_id>477</user_id><user_firstLast_name>Ines Drenjančević</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2014-09</proposal_call><code>IP-2014-09-6380</code><acronim><![CDATA[V-ELI Athero]]></acronim><duration>01.10.2015 - 30.09.2019</duration><status>Završio</status><financ_value>130.332,23 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, Kliničke medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, Clinical sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište Josipa Jurja Strossmayera u Osijeku, Medicinski fakultet Osijek]]></institution_hr><institution_en><![CDATA[Josip Juraj Strossmayer University of Osijek, Faculty of Medicine]]></institution_en><team_members_id>722, 488, 594, 1263, 415, 2779, 482, 548, 487, 1053, 518, 24322, </team_members_id><team_members_names><![CDATA[Kristina Selthofer-Relatić, Martina Mihalj, Anita Ćosić, Mirela Baus Loncar, Ivana Tartaro Bujak, Anita  Horvatić, Zrinka Mihaljević, IVANA GRIZELJ, Ana Čavka, Maro Bujak, Dubravka Mihaljević, Nataša Kozina, ]]></team_members_names><keywords_hr><![CDATA[vazorelaksacija, visoko slana dijeta, endotelno-leukocitna interakcija, angiotenzin II, aterosklerotske lezije, TFF3-/- miševi]]></keywords_hr><keywords_en><![CDATA[vasorelaxation, high salt diet, endothelial-leukocyte interaction, angiotensin II, atherosclerotic lesion, TFF3-/-mice]]></keywords_en><summary_hr><![CDATA[Povećan unos soli hranom potiskuje renin-angiotensin sustav (RAS) i poznat je čimbenik rizika za hipertenziju i kardiovaskularne bolesti. Štoviše, slana dijeta utječe na endotelnu aktivaciju kod aterogenog izobličenja stijenke žile, potičući endotelno-leukocitnu interakciju kod APOE-/- miševa. Oksidativni stres je u podlozi upalnog procesa kod stvaranja aterosklerotskog plaka. Naše prijašnje studije pokazale su da je supresija RAS-a  slanom hranom u podlozi poremećene o endotelu-ovisne diilatacije zbog povećanog oksisdativnog stresa i promjene u stvaranju vazoaktivnih metabolita arahidonske kiseline. Infuzija niskih doza angiotenzina II vodi oporavku relaksacije. Međutim, uloga RAS-a u razvoju rane ateroskleroze se tek nazire. U ovom projektu ispitat ćemo hipotezu da oporavak RAS-a (infuzijom niskih doza angiotenzina II smanjuje endotelno-leukocitnu interakciju (ELI) poništavajući oksidativni stres i proizvodnju proinflamatornih metabolita arahidonske kiseline. Koristit ćemo normotenzivne Sprague Dawley štakore kojima se potiskuje RAS unosom soli i TFF3-/- transgenične miševe. TFF3-/- miševi su potpuna novost u ovom istraživačkom pristupu i obećavajući novi model za proučavanje aterosklerotskih lezija i sinteze proinflamatornih citokina, zbog svojeg protektivnog fenotipa i povoljnog omjera ?6/?-3 masnih kiselina i izmijenjenog metabolizma arahidonske kiseline. Cilj 1: rasvijetliti efekt oporavka RAS-a na mehanizme protokom posredovane dilatacije u životinja na slanoj dijeti. CIlj 2: odrediti utjecaj oporavka RAS-a na interakciju endotelnih stanica i leukocita. Rezultati bi mogli pružiti dokaze za promjenu paradigme o RAS-u kao uvijek štetnom za cirkulaciju i poduprijeti novu paradigmu da je noramlno modulirani RAS ključan u prevenciji stvaranja aterosklerotskih lezija]]></summary_hr><summary_en><![CDATA[High salt (HS) diet suppresses the renin-angiotensin system (RAS) and is known risk factor for hypertension and cardiovascular diseases. Furthermore, HS diet has a direct effect on endothelial activation under atherogenic shear stress, promoting the endothelial-leukocyte interactions in ApoE-/-mice.Oxidative stress underlies inflammatory processes in atherosclerotic plaque formation. Our previous studies demonstrated that RAS suppression by HS diet underlies impaired endothelium-dependant vasorelaxation due to increased oxidative stress and due to the shift in the production of vasoreactive metabolites of arachidonic acid. Infusion of subpressor doses of angiotensin II restored normal vasorelaxation. However, involvement of the RAS in development of early atherosclerosis is only emerging. In this project we will test the hypothesis that restoration of the RAS (by infusions of subpressor doses of angiotensin II) decreases endothelial activation and abolishes endothelial-leukocyte interactions (ELI) by eliminating oxidative stress and the production of proinflammatory metabolites of arachidonic acid. We will use normotensive Sprague-Dawley (SD) rats that exhibit suppression of the RAS with HS intake and in TFF3-/- transgenic mice. TFF3-/- mice are complete novelty in this research approach, and promising new model for studying the atherosclerotic lesion formation and proinflammatory cytokine synthesis, due to their protective phenotype of favorable ratio of ?6/?-3 fatty acids and modified metabolism of arachidonic acid. Aim 1: to elucidate the effect of RAS restoration on the mechanisms of flow-mediated responses in animals on HS diet. Aim 2: to determine the effect of RAS restoration on endothelial cells and leukocytes interactions. The results may provide evidence for the shift in the paradigm that the RAS is always detrimental to circulation and support the new paradigm of crucial role of normally modulated RAS in prevention of atherosclerotic lesion formation]]></summary_en></project><project>
<id>3290</id><title_hr><![CDATA[Primjena mikrosimulacijskih modela u analizi poreza i socijalnih naknada u Hrvatskoj]]></title_hr><title_en><![CDATA[Application of Microsimulation Models in the Analysis of Taxes and Social Benefits in Croatia]]></title_en><user_id>842</user_id><user_firstLast_name>Ivica Urban</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2014-09</proposal_call><code>UIP-2014-09-4096</code><acronim><![CDATA[AMMATSBC]]></acronim><duration>01.09.2015 - 31.08.2018</duration><status>Završio</status><financ_value>34.861,07 eur</financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Ekonomija, </scie_field_hr><scie_field_en>Economy, </scie_field_en><institution_hr><![CDATA[Institut za javne financije]]></institution_hr><institution_en><![CDATA[Institute of Public Finance]]></institution_en><team_members_id>12574, 4472, 12420, 12417, 21291, </team_members_id><team_members_names><![CDATA[Slavko Bezeredi, Saša Jakšić, Chrysa  Leventi, Holly  Sutherland, Martina Pezer, ]]></team_members_names><keywords_hr><![CDATA[mikrosimulacije, modeli, porezi, socijalne naknade, EUROMOD, reforma, ponuda rada, zaposlenost, raspodjela dohotka, siromaštvo]]></keywords_hr><keywords_en><![CDATA[microsimulation, models, taxes, social benefits, EUROMOD, reform, labour supply, employment, income distribution, poverty]]></keywords_en><summary_hr><![CDATA[Mikrosimulacijski model poreza i socijalnih naknada (MSMPN) za svakog pojedinca iz skupa mikropodataka izračunava odgovarajuće iznose poreznih obveza i socijalnih naknada na koje osoba ima pravo. MSMPN omogućuje ex ante pregled učinaka promjena u sustavu poreza i socijalnih naknada i zbog toga je iznimno vrijedan alat u analizi i planiranju reforme.Za razliku od ostalih zemalja EU-a, gdje je uobičajena upotreba MSMPN-a, u Hrvatskoj je razvoj mikrosimulacijskih modela još uvijek u začetku.Zbog toga je svrha ovog projekta primijeniti mikrosimulacijske modele hrvatskih poreza i socijalnih naknada u analizama za potrebe vođenja javne politike i u akademskim analizama. Primjenom mikrosimulacijskih modela u analizi aktualnih ekonomsko-političkih problema ovaj projekt će pokazati korisnost mikrosimulacijskih modela te privući pozornost čelnika javne uprave i akademskih istraživača u Hrvatskoj.Istraživanje ima tri cilja:(1) Razviti mikrosimulacijski model hrvatskih poreza i naknada – miCROmod:miCROmod će biti konvencionalni statički aritmetički MSMPN koji simulira doprinose za socijalno osiguranje, porez na dohodak, zajamčenu minimalnu naknadu, doplatak za djecu, roditeljske naknade i naknadu za nezaposlene. Osim toga, razvit će se: (a) dodatak za jedinice lokalne vlasti, kojim se modeliraju porezi i socijalne naknade u Gradu Zagrebu, i (b) bihevioralni dodatak, koji će simulirati utjecaj promjena instrumenata poreza i socijalnih naknada na ponudu rada i na bruto plaće.(2) Upotrijebiti miCROmod i EUROMOD u analizi poreza i socijalnih naknada:miCROmod i EUROMOD (MSMPN za sve zemlje EU) koristit će se u analizi učinka raznih reformi na nejednakost u raspodjeli dohotka, stope siromaštva i poticaje za rad, a to su reforme: (a) Potpora za djecu, (b) Poreza na dohodak, (c) Instrumenata za povećanje isplativosti rada i (d) Lokalnih socijalnih naknada.(3) Predstaviti djelovanje mikrosimulacijskih modela čelnicima javne uprave i istraživačima.]]></summary_hr><summary_en><![CDATA[Microsimulation model of taxes and social benefits (MSMTBs) calculates for each individual person from a set of microdata the corresponding amounts of taxes payable and social benefits receivable. MSMTBs allow ex ante review of the effects of changes in tax-benefit system. Therefore, they are particularly valuable in the reform analysis and planning.Unlike in other EU countries, where the use of MSMTBs is widespread, the development of MSMTBs in Croatia is still in its infancy.Therefore, the purpose of this project is to apply microsimulation models of Croatian taxes and benefits in public policy and academic analysis. By application of MSMTBs in analysing contemporary economic and policy problems, the project will demonstrate the usefulness of these models, and attract the attention of public administration leaders (PALs) and researchers in Croatia.The research project has three objectives:(1) Develop the microsimulation model of Croatian taxes and benefits – miCROmod:miCROmod will be a conventional static arithmetic MSMTB that simulates social security contributions, personal income tax, guaranteed minimum income, child benefit, parental benefits and unemployment benefit. miCROmod will also include: (a) a local government supplement, modelling taxes and benefits in the City of Zagreb and (b) a behavioural supplement, simulating the impact of changes of tax-benefit instruments on the labour supply and gross wages.(2) Employ miCROmod and EUROMOD in the analysis of tax-benefit reform scenarios:miCROmod and EUROMOD (a comprehensive MSMTB for the EU) will then be used in the the analysis of the effect of a number of tax-benefit reforms on income inequality, poverty rates and incentives to work. These reforms cover: (a) Child benefits, (b) Personal income tax (c) In-work policies, and (d) Local social benefits.(3) Present the performance of miCROmod and EUROMOD to PALs and researchers.]]></summary_en></project><project>
<id>3295</id><title_hr><![CDATA[Geometrijska, ergodička i topološka analiza nisko-dimenzionalnih dinamičkih sustava]]></title_hr><title_en><![CDATA[Geometric, Ergodic and Topological Analysis of Low-dimensional Dynamical Systems]]></title_en><user_id>5838</user_id><user_firstLast_name>Siniša Slijepčević</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2014-09</proposal_call><code>IP-2014-09-2285</code><acronim><![CDATA[GETDYN]]></acronim><duration>01.05.2015 - 30.04.2019</duration><status>Završio</status><financ_value>97.285,82 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Matematika, </scie_field_hr><scie_field_en>Mathematics, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>1391, 3200, 2932, 3100, 5225, 2870, 3173, 5810, 2929, 3773, 2709, 6413, 17706, 22480, 20035, </team_members_id><team_members_names><![CDATA[Vesna Županović, Pavao Mardešić, Goran Radunović, Lana Horvat Dmitrović, Marina Ninčević, Sonja Štimac, Darko Žubrinić, Braslav Rabar, Davor  Dragičević, Domagoj Vlah, Maja Resman, Sibe Mardešić, Ana Anušić, Milena Vulević, Kristijan Kilassa Kvaternik, ]]></team_members_names><keywords_hr><![CDATA[Dinamički sustavi, Fraktalna dimenzija, Fraktalna zeta funkcija, Potkovno preslikavanje, Stabilnost, Bifurkacija, Navier-Stokesova jednadžba]]></keywords_hr><keywords_en><![CDATA[Dynamical systems, Fractal dimension, Fractal zeta function, Horseshoe map, Stability, Bifurcation, Navier-Stokes Equation]]></keywords_en><summary_hr><![CDATA[Naš znanstveni rad će se fokusirati na unapređenje i dalji razvoj aktualnih uzbudljivih i važnih rezultata članova tima, objavljenih u vodećim međunarodnim časopisima (u zadnjih 5 godina, 18 Q1 i 9 Q2 članaka). Recentni rezultati uključuju: Rješenje Ingramove hipoteze te bolje razumijevanje atraktora Henonovog te Loci preslikavanja, koji su među najproučavanijim dinamičkim sustavima (S. Štimac); Razvoj novih definicija fraktalnih invarijanti, te karakterizacija graničnih ciklusa u terminima fraktalne dimenzije (V. Županović); Razumijevanje dinamike poznatih sustava koji uključuju vučeni Frenkel-Kontorova model, te Navier-Stokesovu jednadžbu, primjenjujući ergodsko-teorijske te slične alate (S. Slijepčević), te Uvođenje, etabliranje i razvoj novih fraktalnih zeta funkcija kao važan alat u dinamičkim sustavima (D. Žubrinić).Uz znanstveni razvoj, naši ciljevi uključuju osnivanje novih plodnih istraživačkih suradnji na međunarodnom nivou, kao i nastavak postojećih produktivnih i aktivnih suradnji s više od 15 međunarodnih sveučilišta. Također ćemo osigurati da naše istraživanje ima veću vidljivost i utjecaj, te ćemo tražiti fizikalne i inžinjerske primjene i suradnju. Konačno, namjeravamo nastaviti kao i do sad, s 5 studenata koji su doktorirali u posljednje 3 godine, često u suradnji s vodećim međunarodnim sveučilištima i stručnjacima (Dijon, California Riverside), te s post-doktorantima koji nastavljaju utjecajna istraživanja na međunarodnom nivou.Fokus našeg projekta je također dalji razvoj našeg nedavno osnovanog Centra za nelinearnu dinamiku (www.math.hr/cnd), kao regionalnog centra za istraživanje iz dinamičkih sustava, jednog od ključnih područja čiste i primijenjene matematike.]]></summary_hr><summary_en><![CDATA[Our scientific work will focus on advancement and further development of recent exciting and important results of the team members, published in the leading international journals (in the last 5 years 18 Q1 and 9 Q2 articles). The recent results include: Solution of the Ingram’s hypothesis and better understanding of attractors of Henon’s and Lozi map, one of the most studied dynamical systems (S. Štimac); Developing of new definitions of fractal invariants, and characterizations of limit cycles in terms of fractal dimension (V. Županović); Understanding of dynamics of well-known systems including the driven Frenkel-Kontorova model and the Navier-Stokes equation by applying ergodic-theoretical and related tools (S. Slijepčević), and Introducing, establishing and developing new fractal zeta functions as an important tool in dynamical systems (D. Žubrinić). In addition to scientific advancement, our general objectives include establishing new fruitful research collaborations at the international level, as well as continuing existing productive and active collaboration with over 15 leading international universities. We will also make sure our research is more visible and with more impact, and will look for physical and engineering applications and collaborations. Finally, we plan to continue our track record of 5 students completing their PhD’s in the last three years, often in collaboration with the leading international universities and experts (Dijon, California Riverside), and that postdocs continue impactful research at the international level. Focus of our project is also further development of our recently founded Centre for nonlinear dynamics (www.math.hr/cnd), as a regional centre for resarch in dynamical systems, as one of the key areas of pure and applied mathematics.]]></summary_en></project><project>
<id>3298</id><title_hr><![CDATA[ Determinante uspješnosti poslovanja poduzeća]]></title_hr><title_en><![CDATA[Determinants of firms&#39; success and failure]]></title_en><user_id>11292</user_id><user_firstLast_name>Maja Pervan</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2014-09</proposal_call><code>UIP-2014-09-1745</code><acronim><![CDATA[DETSUCCFAIL]]></acronim><duration>01.10.2015 - 30.09.2018</duration><status>Završio</status><financ_value>20.731,42 eur</financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Ekonomija, </scie_field_hr><scie_field_en>Economy, </scie_field_en><institution_hr><![CDATA[Sveučilište u Splitu, Ekonomski fakultet]]></institution_hr><institution_en><![CDATA[University of Split, Faculty of Economics, Business and Tourism]]></institution_en><team_members_id>11294, 11316, 11319, </team_members_id><team_members_names><![CDATA[Ivica Pervan, Marijana Ćurak, Tomislava Pavić Kramarić, ]]></team_members_names><keywords_hr><![CDATA[Uspješnost poslovanja poduzeća, profitabilnost, prerađivačka industrija, bankrot, dinamička panel analiza, multipla regresija, logistička regresija]]></keywords_hr><keywords_en><![CDATA[Firms&#39; success, profitability, manufacturing industry, bankruptcy, dynamic panel analysis, multiple regression, logistic regression  ]]></keywords_en><summary_hr><![CDATA[Poslovni uspjeh poduzeća predstavlja važnu, aktualnu i neiscrpnu temu istraživanja koja izaziva interes brojnih znanstvenika i stručnjaka iz prakse. U sadašnjem kontekstu tržišne liberalizacije, rastuće konkurencije, tehnoloških inovacija i ukidanja trgovinskih barijera, istraživanje determinanti koje su relevantne i značajne u objašnjavanju poslovnog uspjeha poduzeća postaje od krucijalne važnosti.Uvažavajući prethodno, prvi cilj ovog istraživanja je kreirati model koji će identificirati čimbenike koji određuju uspjeh poduzeća. U usporedbi s postojećim empirijskim istraživanjima, kreirani model će biti unaprijeđen na nekoliko načina: (1) uz zahvaćanje dinamičkog aspekta poslovnog uspjeha poduzeća, model će istodobno analizirati determinante na razini poduzeća, industrije i makro-okruženja; (2) razmatrat će nelinearne efekte pojedinih determinanti profitabilnosti, kao i primjenu različitih mjera performansi (tradicionalnih i indikatora performansi novčanog toka). Formulacija takvog modela ne postoji u hrvatskoj prerađivačkoj industriji kao ni u zemljama središnje i istočne Europe. Osim identifikacije determinanti uspješnosti poslovanja poduzeća, namjera se kreirati i model koji će biti u mogućnosti prognozirati vjerojatnost bankrota poduzeća. Uz tradicionalne mjere performansi, u istraživanju će se koristiti i Operating Cash Flow Capacity što predstavlja originalnu ideju i unaprjeđenje dosadašnjih modela budući da ova varijabla može biti pouzdanija od neto dobitka s obzirom na latentni problem manipulacija dobitkom. Prema našim spoznajama, niti jedno drugo istraživanje nije koristilo ovu mjeru performansi za predviđanje bankrota poduzeća. Dodatno, u ovom istraživanju će se koristiti i pristup s tri ili više grupa statusa neuspjeha poduzeća. Za ovaj dio istraživanja primijenit će se logistička regresija kao i nova, sofisticirana ekonometrijska metoda, neuronske mreže.]]></summary_hr><summary_en><![CDATA[The issue of firm business success is an important, actual and inexhaustible subject that draws attention of many scientific researchers and practitioners. In the present context of market liberalization, increased competition, technological innovation and vanishing trade barriers, the investigation of the determinants that are relevant and significant in explaining firms’ business success becomes crucial.Having previous in mind, the first goal of this research proposal is to create a model that will identify factors that determine firms&#39; success. When compared with the previous empirical research, the designed model will be improved in several ways: (1) it will encompass the dynamic aspect of firms’ success while simultaneously analysing firm-level, industry-level and macroeconomic determinants of profitability; (2) it will consider nonlinear effects of profitability determinants and different measures of performance (traditional and cash flow performance indicators). Formulation of such a model doesn’t exist, not only in the Croatian manufacturing sector, but even in the Central and Eastern Europe.Aside from identifying the drivers of firms’ success, we also intend to determine the factors that explain firms’ financial failure i.e. we will create a model that will be able to predict the probability of firms’ bankruptcy. Besides using traditional firms’ performance indicators we will also use an Operating Cash Flow Capacity, what represents original idea and improvement of modelling since this variable could be more reliable than net income regarding the latent problem of earnings management. As far as we know, no other research before used this measure of performance for the prediction of a firms’ failure (bankruptcy). Additionally, we will use an approach with three or more classes of firm failure status. For this part of the research, the logistic regression as well as a novel and sophisticated econometric method i.e. neural networks will be applied.]]></summary_en></project><project>
<id>3302</id><title_hr><![CDATA[Centromerna genomika beskralješnjaka]]></title_hr><title_en><![CDATA[Invertebrate centromere genomics]]></title_en><user_id>506</user_id><user_firstLast_name>Miroslav Plohl</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2014-09</proposal_call><code>IP-2014-09-3183</code><acronim><![CDATA[CENGEN]]></acronim><duration>01.10.2015 - 30.11.2020</duration><status>Završio</status><financ_value>132.324,64 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Biologija, </scie_field_hr><scie_field_en>Biology, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>332, 12849, 2778, 5779, 1030, 508, 21387, 21386, 22650, </team_members_id><team_members_names><![CDATA[Brankica Mravinac, Fernando Azorin, Eva Šatović, Nevenka Meštrović, CASTAGNONE Philippe, Barbara Mantovani, Evelin Despot Slade, Tena Gržan, Monika Tunjić, ]]></team_members_names><keywords_hr><![CDATA[centromera, CenH3, satelitna DNA, ponovljena DNA, evolucija, kornjaši, oblići, školjkaši]]></keywords_hr><keywords_en><![CDATA[centromere, CenH3, satellite DNA, repetitive DNA, evolution, beetles, nematodes, molluscs]]></keywords_en><summary_hr><![CDATA[Centromera je domena esencijalna za razdvajanje kromosoma u staničnim diobama. Razumijevanje centromerne strukture i funkcije od velikog je značaja u biologiji, a značajno je i s biomedicinskog stajališta. Funkcionalne centromere obilježene su centromerno specifičnim proteinom sličnim histonu H3 (CenH3). Centromerni identitet određuju i genomski i epigenetički mehanizmi, koji podstiču brzu koevoluciju i vrsnu specifičnost proteina CenH3 i njemu pridruženih sekvenci DNA bez narušavanja centromerne funkcije. Složenost i varijabilnost centromernog područja uzrok su još uvijek fragmentalne percepcije centromerne genomike, koja je razrađena samo na nekoliko biljnih i životinjskih modelnih organizama. Sekvencirani genomi modelnih organizama beskralješnjacima s različitom konstitucijom centromernih regija nedavno su postali dostupni. Kornjaši roda Tribolium imaju centromere uklopljene duboko u pericentromerni heterokromatin bogat satelitnim DNA, oblići korijenovih kvržica roda Meloidogyne imaju holocentrične kromosome, dok školjkaš Crassostrea gigas ima nejednoliku razdiobu satelitnih DNA u centromerama. Glavni cilj ovog projektnog prijedloga je identificirati CenH3 i njima pridružene sekvence DNA, kao i njihove nefunkcionalne varijante kako bi se istražila genomika različito organiziranih centromera. Nadalje, biti će ispitani organizacijski i evolucijski obrasci proteina CenH3 i centromernih sekvenci DNA. Strategija istraživanja kombinira identifikaciju CenH3, kromatinsku imunoprecipitaciju (ChIP) s antitijelima na CenH3, fluorescencijsku hibridizaciju in situ (FISH), imunofuorescencijsku lokalizaciju in situ (IF) i bioinformatičke metode. Takav integrativni pristup će ponuditi informacije o ovim funkcionalno značajnim dijelovima koji najčešće nedostaju u sekvenciranim genomima i unaprijediti naše razumijevanje sinergije i koevolucije centromernih sekvenci DNA i proteinskih komponenata. ]]></summary_hr><summary_en><![CDATA[The centromere is a domain essential for chromosomal segregation in cell divisions. Understanding its structure and function is of the highest importance in biology, and also crucial from biomedical point of view. Functional centromeres are marked by centromere-specific histone H3-like proteins (CenH3). Centromere identity involves both genomic and epigenetic mechanisms, favoring rapid co-evolution and species specificity of CenH3 and associated DNA sequences without impairing the function. Complexity and variations make perception of centromere genomics still fragmental and worked out only in a few most common plant and animal model systems. Among invertebrates, sequenced genomes of model organisms with diverse constitution of centromeric regions became recently available. Tribolium beetles have centromeres embedded deeply into the satellite DNA-rich pericentromeric heterochromatin, Meloidogyne root-knot nematodes have holocentric chromosomes, while the mollusk Crassostrea gigas lacks uniform distribution of satellite DNAs in centromeres. The main goal of this research proposal is to identify CenH3 and CenH3-associated DNA sequences as well as their non-functional genomic counterparts in order to explore genomics of differently organized centromeres. In addition, organizational and evolutional aspects of CenH3 and centromeric DNA sequences will be addressed. The research strategy will combine CenH3 identification, chromatin immunoprecipitation (ChIP)-based assays using anti-CenH3 antibodies, fluorescence in situ hybridization (FISH), immunofluorescence in situ localization (IF) and the bioinformatics pipeline. Such integrative approach will help filling the gaps in functionally essential regions of sequenced genomes and will forward our understanding of the synergy and coevolution between DNA sequences and protein components in the centromeres.  ]]></summary_en></project><project>
<id>3303</id><title_hr><![CDATA[Razumjevanje puta ulaska Adenovirusa tipa 26 u stanicu: način poboljšanja vektora za vakcinaciju]]></title_hr><title_en><![CDATA[Understanding cell entry pathway of Adenovirus type 26: way of improving vaccine vectors]]></title_en><user_id>12819</user_id><user_firstLast_name>Dragomira Majhen</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2014-09</proposal_call><code>UIP-2014-09-3912</code><acronim><![CDATA[AdVEntPathVac]]></acronim><duration>01.09.2015 - 31.08.2018</duration><status>Završio</status><financ_value>66.361,40 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Biologija, </scie_field_hr><scie_field_en>Biology, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>13083, 4830, 3972, </team_members_id><team_members_names><![CDATA[Jelena Knežević, Mladen Krajačić, Jelena Ruščić, ]]></team_members_names><keywords_hr><![CDATA[adenovirus tip 26, vektor, vakcinacija, unutarstanično putovanje, TLR, urođeni imunološki odgovor]]></keywords_hr><keywords_en><![CDATA[adenovirus type 26, vector, vaccination, intracellular trafficking, TLR, innate immune response]]></keywords_en><summary_hr><![CDATA[Adenovirusni  vektori imaju potencijalno translacijsku i komercijalnu vrijednost, a trenutno se istražuju kao vektori za prijenos DNA i vakcinu. Imunogeničnost adenovirusa tipa 26 (AdV26) značajno se razlikuje od drugih adenovirusnih vektora  što bi mu moglo dati  prednost pred ostalim adenovirusnim serotipovima u razvoju vakcina. Trenutno nema studija koje opisuju ulazak AdV26 u stanicu ističući potrebu za istraživanjem načina na koji AdV 26 inficira stanicu. U skladu s tim, ciljevi ovog projekta su istraživanje AdV26 receptora, vezanja i internalizacije AdV26 u ciljnu stanicu, AdV26 unutarstaničnog putovanja te urođenog imunološkog odgovora potaknutog infekcijom AdV26. Naši znanstveni ciljevi su novi i inovativni te usmjereni prema stvaranju novih znanja i rješenja kliničkih problema, a predložene metode koriste trenutno stanje tehnike. Ovim projektom uvodimo novo istraživanje u području adenovirusnih  vektora što našu grupu stavlja na uzbudljiv i vodeći rub istraživanja adenovirusa. Uspostavom ovog istraživanjanaša bi grupa postala dio mreže industrijsko-akademskog partnerstva u bazičnim i translacijskim istraživanjima adenovirusa u Europi što bi nam omogućilo ostvarivanje daljnjih suradnji i povećalo mogućnost dobivanja novih financiranja u budućnosti. Vjerujemo da će nova znanja koja će proizaći iz našeg istraživanja imati značajan utjecaj u području istraživanja  te biti od koristi kako akademskoj zajednici tako i industriji. Naša grupa, čije se osnivanje predlaže u ovom projektu, jedina je istraživačka grupa koja proučava bazičnu biologiju adenovirusnih vektora u Hrvatskoj čime se osigurava nastavak aktivnog istraživanja adenovirusa u Institutu Ruđer Bošković.]]></summary_hr><summary_en><![CDATA[Adenovirus (AdV) based vectors have potential translational and commercial values and are currently studied as vectors for DNA transfer and vaccination. Adenovirus type 26 (AdV26) has fundamental differences in immunogenicity from other AdV vectors, which might give it advantage over other AdV serotypes in vaccine vector development. To the best of our knowledge there are no reports describing AdV26 entry pathway underlining the need for studying infection pathway used by AdV26. Accordingly, the main objectives of this study are investigating AdV26 receptor usage, binding, internalization, intracellular trafficking and AdV26 mediated induction of innate immune response. Our scientific objectives are novel, innovative and designed to generate new knowledge and opportunities for therapeutic advances in areas of unmet clinical need. Our technical objectives use state-of-the-art, span academic and industrial specialties creating cross sector knowledge and long lasting inter-sectoral benefits. With this project we will introduce new line of AdV vector research in our group that would position us on the exciting and cutting edge of AdV research. Herewith we will become part of long lasting network of industrial–academic partnership in adenovirus basic and translational research across Europe granting lasting collaborations and increasing possibilities for obtaining new grants in the future. We believe that outputs of our research will have considerable impact on the field through gaining new knowledge from which both academia and industry will benefit. Our group, whose establishment is proposed in this project, is the only research group that studies basic biology of adenovirus vectors in Croatia and this grant proposal represents continuation of active adenovirus research in Ruđer Bošković Institute.]]></summary_en></project><project>
<id>3304</id><title_hr><![CDATA[Morski plankton kao alat za procjenu klimatskog i antropogenog utjecaja na morski ekosustav]]></title_hr><title_en><![CDATA[Marine plankton as a tool for assessment of climate and anthropogenic influence on the marine ecosystem]]></title_en><user_id>2662</user_id><user_firstLast_name>Živana Ninčević Gladan</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2014-09</proposal_call><code>IP-2014-09-3606</code><acronim><![CDATA[MARIPLAN]]></acronim><duration>01.06.2015 - 30.11.2019</duration><status>Završio</status><financ_value>132.722,81 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Biologija, Fizika, Geologija, Kemija, </scie_field_hr><scie_field_en>Biology, Physics, Geology, Chemistry, </scie_field_en><institution_hr><![CDATA[Institut za oceanografiju i ribarstvo]]></institution_hr><institution_en><![CDATA[Institute of Oceanography and Fisheries]]></institution_en><team_members_id>6243, 207, 5789, 5840, 5284, 6017, 2761, 3007, 2983, 3031, 3130, 5818, 6043, 6741, 5979, 6799, </team_members_id><team_members_names><![CDATA[Olja Vidjak, Natalia Bojanić, Sanda Skejić, Mia Bužančić, Grozdan Kušpilić, Slavica Matijević, Branka Grbec, Gordana Beg Paklar, Tomislav Džoić, Žarko Kovač, Ivana Ujević, Jasna Arapov, Jelena Mandić, Jelena Lušić, Darko Koracin, Danijela Bogner, ]]></team_members_names><keywords_hr><![CDATA[morski plankton, antropogeni utjecaj, klimatske promjene, ekološko modeliranje, ciste dinoflagelata, Jadransko more]]></keywords_hr><keywords_en><![CDATA[marine plankton, anthropogenic influence, climate change, ecological modelling, dinoflagellate cysts, Adriatic Sea]]></keywords_en><summary_hr><![CDATA[Zbog vrlo duge obalne linije, morske orijentacije i iznimne gospodarske važnosti morskih resursa u Republici Hrvatskoj, razumijevanje utjecaja suvremenih globalnih megatrendova kao što su klimatske promjene i rastući antropogeni pritisci na morski okoliš trenutno predstavljaju ključni problem. Ovaj je projektni prijedlog usmjeren na promjene u zajednicama morskog planktona zbog njegovog brzog odgovora na promjene u okolišu. Istraživačke aktivnosti organizirane su kroz dva usko povezana istraživačka modula: Modul 1 - Antropogeni utjecaj na morski okoliš i Modul 2 - Istraživanja posljedica klimatskih promjena na planktonske zajednice. Aktivnosti vezane uz Modul 1 odvijati će se kombiniranjem podataka o prostornoj raspodjeli, intenzitetu i posljedicama antropogenih utjecaja s raspoloživim dugoročnim nizovima podataka o gustoći i strukturi planktonskih populacija u priobalnim vodama i ekološkim i taksonomskim istraživanjima u prijelaznim vodama (Projektni zadatak 1.1,), istraživanjem taloženja i bioakumulacije po zdravlje opasnih organskih spojeva i teških metala u morskom ekosustavu (Projektni zadatak 1.2) i kvantificiranjem disperzije čestica korištenjem lagranžijanskog modela (Projektni zadatak 1.3.). Utjecaj klimatskih promjena na morski plankton će se istraživati utvrđivanjem odnosa između klime i populacija pomoću dugoročnih nizova oceanografskih i planktonskih podataka koristeći inovativne statističke metode (Projektni zadatak 2.1) i kroz praćenje klimatskih promjena putem identifikacije i kronologije bioloških vremenskih kapsula kao što su dinoflagelatne ciste (Zadatak 2.2., Pilot projekt Lingulodinium polyedrum). Predloženi projekt predstavlja inovativan pristup u proučavanju klimatski i ekološki uvjetovanih promjena morskih planktonskih populacija. Očekujemo da će rezultati projekta doprinijeti uspostavi trajnih rješenja usmjerenih na  praćenje zdravlja mora. ]]></summary_hr><summary_en><![CDATA[Due to the long coastal line, marine orientation and economic importance of sea-based resources in the Croatia, understanding how recent global megatrends such as changing climate and growing anthropogenic influence affect the marine environment is currently the key issue. This project proposal is targeting changes in the marine plankton due to fast response to environment changes. The research activities are organized in two highly interconnected research modules: (Module 1) Anthropogenic influence on the marine environment and (Module 2) Investigations of climate changes on ecological processes and plankton communities.Module 1 related activities are to be studied by combining data on spatial distribution, intensity and consequences of human impacts with available time-series data on abundances and population structure of plankton communities in coastal waters, and by taxonomic research in transitional waters (Task 1.1.), by determining deposition and bioaccumulation of health-threatening organic compounds and heavy metal contaminants in the marine ecosystem (Task 1.2.) and by quantifying dispersion of particles through the use of Lagrangian models (Task 1.3.). Climate change impacts on marine plankton will be investigated by identifying climate-population connections using long-term oceanographic and plankton data series through the innovative synthesis techniques (Task 2.1) and by tracing the climate related changes through identification and chronology of biological time capsules such as dinoflagellate cysts (Task 2.2., Pilot project Lingulodinium polyedrum). The proposed project represents a novel approach to the study of climatologically and environmentally driven changes to the marine plankton populations. The results are expected to make contribution towards the long-term program of ecological monitoring that is needed to track the sea health, address the current climate issues, and maximize the potential to recommend permanent solutions.]]></summary_en></project><project>
<id>3309</id><title_hr><![CDATA[Oscilatorna dinamika citoskeleta]]></title_hr><title_en><![CDATA[Oscillatory dynamics of the cytoskeleton]]></title_en><user_id>11207</user_id><user_firstLast_name>Iva Tolić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2014-09</proposal_call><code>IP-2014-09-4753</code><acronim><![CDATA[OSCITON]]></acronim><duration>01.09.2015 - 30.09.2019</duration><status>Završio</status><financ_value>132.722,81 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Biologija, Fizika, </scie_field_hr><scie_field_en>Biology, Physics, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>7715, 6276, 4004, 12534, 12533, 13281, 13288, 21341, 25284, </team_members_id><team_members_names><![CDATA[Igor Weber, Nenad Pavin, Matko Glunčić, Maja Marinović, Marko Šoštar, Maja Novak, Marcel Prelogović, Mihaela Jagrić, Lucija Mijanović, ]]></team_members_names><keywords_hr><![CDATA[citoskelet, mikrotubuli, motorni proteini, diobeno vreteno, stanično kretanje, Rho GTPaze, mikroskopija, teorijsko modeliranje]]></keywords_hr><keywords_en><![CDATA[cytoskeleton, microtubules, motor proteins, mitotic spindle, cell migration, Rho GTPases, microscopy, theoretical modeling]]></keywords_en><summary_hr><![CDATA[Oscilacije u citoskeletu važne su za biologiju stanice kao sredstvo prostorne i vremenske regulacije stanične organizacije, diobe stanica i njihove pokretljivosti. U projektu OSCITON istraživat ćemo dva oscilatorna procesa. Kao prvo, proučavat ćemo mehanizam oscilacija kinetohora koje pokreću mikrotubuli tijekom mitoze, te utjecaj kinezina-8 na taj proces. Te oscilacije stvaraju sile napetosti između sestrinskih kinetohora, bez kojih stanica ne može proći kontrolnu točku u metafazi. Oscilacije ćemo proučavati uz pomoć naprednih tehnika svjetlosne mikroskopije u HeLa stanicama u kojima ćemo eksprimirati tubulin-GFP i kinetohorni protein mRFP-Cenp-B, te smanjiti ili pojačati ekspresiju kinezina-8. Da bismo proučavali sile koje djeluju na kinetohore, promijenit ćemo ravnotežu sila laserskom mikrodisekcijom mikrotubula vezanih na kinetohore. Paralelno s eksperimentima razvit ćemo teorijski model, koji će omogućiti interpretaciju utjecaja kinezina-8 na oscilacije. Kao drugo, proučavat ćemo oscilatornu repolarizaciju stanica Dictyostelium tijekom njihovog nasumičnog gibanja. Pretpostavljamo da kompeticija efektorskih kompleksa DGAP1/korteksilin i Scar/Wave za zajednički aktivator Rac1 igra središnju ulogu u repolarizaciji. Kako bismo testirali ovu hipotezu, koristit ćemo novu fluorescentnu sondu za aktivni Rac1, stanice s poremećenom ravnotežom efektorskih kompleksa, te stanice sa reduciranom funkcionalnošću proteina Rac1. Eksperimentalno i teorijski ćemo proučavati dinamiku Rac1, njegovih efektora, te F-aktina u stanicama divljeg tipa i mutiranih sojeva. Ovaj će interdisciplinarni projekt omogućiti optimalno korištenje resursa i okupiti znanstvenike s iskustvom u širokom rasponu disciplina od molekularne i stanične biologije, biokemije, mikroskopije do teorijske biofizike. Udruživanjem svih istraživača iz područja dinamike citoskeleta u Hrvatskoj okupit ćemo tim koji će igrati važnu ulogu u tom području istraživanja na međunarodnoj razini.]]></summary_hr><summary_en><![CDATA[Oscillations in the cytoskeleton are of general importance in cell biology as a means of spatial and temporal regulation of the cellular organization, cell division and motility. The project OSCITON focuses on two oscillatory processes. First, we will investigate the mechanism of microtubule-driven kinetochore oscillations during mitosis, and the role of kinesin-8 motors in this process. These oscillations generate tension between sister kinetochores, which is required to pass the spindle checkpoint. We will use HeLa cells expressing tubulin-GFP and mRFP-CENP-B, a kinetochore protein, in combination with advanced light microscopy and depletion or overexpression of kinesin-8 motors. To study the forces acting on kinetochores, we will perturb the force balance by performing laser microsurgery of the microtubules attached to kinetochores. The experiments will be accompanied by the development of a theoretical model, which will allow us to explore the role of kinesin-8 in the oscillations. Second, we will study the oscillatory repolarization of Dictyostelium cells during random migration. We propose that the competition of DGAP1/cortexillin and SCAR/Wave complexes for the common activator Rac1 plays a central role in this process. To test this hypothesis, we will use a novel fluorescent probe for active Rac1 GTPases, generate cells with disturbed balance of Rac1 effectors, and cells deficient in functional Rac1. Dynamics of the probes for Rac1, its effectors, and F-actin will be studied experimentally in live cells and theoretically. This interdisciplinary project is designed to optimize the use of resources and bring together researchers with the expertise in a range of disciplines, including molecular and cellular biology, biochemistry, microscopy, and theoretical biophysics. Through joining forces of all investigators of the cytoskeletal dynamics in Croatia, we intend to assemble a team that will play a prominent role in this field of research internationally.]]></summary_en></project><project>
<id>3311</id><title_hr><![CDATA[Napredna 3D percepcija za mobilne robotske manipulatore]]></title_hr><title_en><![CDATA[Advanced 3D Perception for Mobile Robot Manipulators]]></title_en><user_id>6310</user_id><user_firstLast_name>Robert Cupec</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2014-09</proposal_call><code>IP-2014-09-3155</code><acronim><![CDATA[ARP3D]]></acronim><duration>01.01.2016 - 31.12.2019</duration><status>Završio</status><financ_value>125.918,24 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Elektrotehnika, Računarstvo, </scie_field_hr><scie_field_en>Electrical engineering, Computer sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište Josipa Jurja Strossmayera Osijek, Fakultet elektrotehnike, računarstva i informacijskih tehnologija Osijek]]></institution_hr><institution_en><![CDATA[Josip Juraj Strossmayer University of Osijek, Faculty of Electrical Engineering, Computer Science and Information Technology Osijek]]></institution_en><team_members_id>7327, 5672, 6349, 2970, 7388, 7566, 7308, 7332, 18997, 21326, 22820, </team_members_id><team_members_names><![CDATA[Ivan Vidović, Damir Filko, Ratko Grbić, Emmanuel Karlo  Nyarko, Tomislav Keser, Ivan Aleksi, Ivica Lukić, Tomislav Matić, Marina Peko, Petra Đurović, Marko Filipović, ]]></team_members_names><keywords_hr><![CDATA[računalni vid, robotska manipulacija, prepoznavanje objekata, lokalizacija robota, segmentacija, 3D senzori]]></keywords_hr><keywords_en><![CDATA[computer vision, robot manipulation, object recognition, robot localization, segmentation, 3D sensors]]></keywords_en><summary_hr><![CDATA[Unatoč naglom napretku 3D računalnog vida, još uvijek postoji potreba za učinkovitijim, pouzdanijim i fleksibilnijim sustavima robotske percepcije. Osnovni cilj ovog projekta je razviti nove odnosno unaprijediti postojeće metode 3D robotskog vida za primjenu u zadacima robotske manipulacije. Predloženo istraživanje obuhvaća primjenu 3D senzora za izvođenje prototipnih zadataka koji uključuju manipulaciju objektima u kombinaciji sa samostalnim kretanjem u nestrukturiranoj okolini. Težište istraživanja je na robotskoj percepciji zasnovanoj na 3D oblacima točaka dobivenim 3D senzorima, dok su planiranje kretanja i hvatanja objekata uključeni samo radi evaluacije razvijenih rješenja s područja računalnog vida. Istraživanje će se provoditi u tri smjera: (i) segmentacija oblaka točaka i 3D modeliranje; (ii) prepoznavanje objekata; (iii) lokalizacija mobilnog robota. Radi olakšavanja komunikacije između čovjeka i robota, bit će razvijena metoda segmentacije oblaka točaka, koja će rezultirati modelom okoline u obliku zasebnih objekata relevantnih za mobilnu manipulaciju, što će omogućiti korisniku zadavanje zadataka robotu na jednostavan i intuitivan način. Razvijat će se više novih metoda s primjenom u okviru uobičajene strategije raspoznavanja objekata zasnovanog na značakama s ciljem povećanja računske učinkovitosti uz istovremeno postizanje visoke preciznosti i osjetljivosti (engl. precision and recall). Radit će se na osmišljavanju novih značajki za učinkovito generiranje hipoteza. Također će se razvijati nova metoda procjenjivanja vjerojatnosti generiranih hipoteza. Uz ovaj pristup, istraživat će se i primjena slučajnog evolucijskog algoritma pretraživanja te metode podudaranja grafova u prepoznavanju objekata. Razvijeni sustav prepoznavanja objekata bit će nadograđen i prilagođen za prepoznavanje mjesta u okviru sustava za lokalizaciju mobilnog robota. Sve metode razvijene u okviru projekta ispitat će se pokusima s mobilnim robotskim manipulatorom.]]></summary_hr><summary_en><![CDATA[Despite rapid advancement in 3D computer vision, there is still a need for more efficient, reliable and flexible robot perception systems. The main goal of this project is to develop new or improve existing 3D robot vision methods for application in mobile robot manipulation tasks. The proposed research considers application of 3D sensors in execution of prototypical tasks which include object manipulation combined with autonomous motion in an unstructured environment. The focus of the research is on robot perception based on 3D point clouds obtained by 3D sensors, while motion planning and grasping are involved only for the purpose of evaluation of the developed vision-based solutions. The research will be conducted in three directions: (i) point cloud segmentation and 3D modelling; (ii) object recognition; (iii) mobile robot localization. In order to facilitate human-robot communication, a point cloud segmentation method will be developed which will create environment models in the form of separate geometric objects relevant for mobile robot manipulation, providing a user with a simple and intuitive means of defining robot manipulation tasks. Several novel approaches within the framework of a common feature-based object recognition pipeline will be developed with the purpose of increasing the computational efficiency while achieving a high precision-recall characteristic. Novel features for efficient hypothesis generation will be designed. A novel hypothesis probability estimation approach will be developed. Furthermore, application of a random evolutionary search algorithm and graph matching in object recognition will be investigated. The developed object recognition system will be extended and adapted for place recognition within a mobile robot localization framework. All developed approaches will be evaluated by experiments with a mobile robot manipulation.]]></summary_en></project><project>
<id>3317</id><title_hr><![CDATA[Molekularni posrednici koštane resorpcije uvjetovane receptorom Fas u artritisu ]]></title_hr><title_en><![CDATA[Molecular mediators of Fas-driven osteoresorption in arthritis]]></title_en><user_id>3882</user_id><user_firstLast_name>Nataša Kovačić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2014-09</proposal_call><code>IP-2014-09-7406</code><acronim><![CDATA[MEFRA]]></acronim><duration>01.11.2015 - 31.10.2019</duration><status>Završio</status><financ_value>132.722,81 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, Kliničke medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, Clinical sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb School of Medicine]]></institution_en><team_members_id>3075, 2631, 3895, 4356, 4791, 4786, 13283, 3832, 13336, 13320, 4651, 20922, 22476, 22466, </team_members_id><team_members_names><![CDATA[Danka Grčević, Tomislav Kelava, Alan Šućur, Frane Paić, Branimir Anić, Mislav Cerovec, Katerina Zrinski Petrovic, Elvira Lazić Mosler, Peter Ian Croucher, Nives Zimmermann, Mislav Jelić, Katarina Barbarić, Martina Fadljević, Igor Radanović, ]]></team_members_names><keywords_hr><![CDATA[artritis, Fas, osteoresorpcija, stanična loza, diferencijacija, apoptoza, upala]]></keywords_hr><keywords_en><![CDATA[arthritis, Fas, osteoresorption, lineage, differentiation, apoptosis, inflammation]]></keywords_en><summary_hr><![CDATA[Upalni artritisi su kronične zglobne bolesti, i važan zdravstveni problem zbog progresivne invalidnosti. Najčešći je reumatoidni arthritis (RA) praćen oštećenjem kosti i hrskavice, koji dovode do trajnih deformacija zgloba. Artritis se također često javlja tijekom sistemskog lupusa eritematosusa (SLE), uglavnom kao neerozivni artritis.Tijekom RA, upalne i imunološke stanice stvaraju mikrookoliš koji izaziva resorpciju kosti, potičući sazrijevanje i aktivnost osteoklasta, a kočeći sazrijevanje i aktivnost osteoblasta. Lijekovima poput bioloških sredstava može se promijeniti tijek bolesti, ali ograničeno je djelovanje na koštanu resorpciju. Sustav Fas/Fas ligand važan je regulatore homeostaze imunološkog sustava, a sve je više dokaza  o njegovoj važnosti u regulaciji koštane homeostaze. Inaktivacija receptora Fas štiti od gubitka kosti izazvanog nedostatkom estrogena, ali i gubitka kosti u upalnom artritisu, međutim stanične loze i signalni putevi koji posreduju taj učinak još nisu u potpunosti poznati. Korištenjem modela artritisa potaknutog antigenom (AIA, prema engl. antigen-induced arthritis) u miševa s izbačenim genom za Fas, te uzoraka sinovijalne tekućine bolesnika s RA i SLE, namjeravamo istražiti fenotip staničnih populacija odgovornih za kočenje osteoresorptivnih zbivanja, te utvrditi funkcijske promjene u tim stanicama globalnom analizom njihovog genskog izražaja. Nadalje, očekujemo da ćemo potvrditi značaj promijenjenih gena/bjelančevina njihovom inaktivacijom in vivo u mišjem modelu AIA, a važnost pojedine loze utvrdit ćemo uporabom miševa sa izbačenim genom za Fas u toj lozi. Analiza ljudskih uzoraka omogućit će razumijevanje značenja navedenih promjena u kliničkoj primjeni.   Naš pristup ima za cilj otkriti nove molekularne posrednike koštane resorpcije u upalnim artritisima, na razini specifičnoj za staničnu lozu. Predloženo istraživanje otvorit će nove mogućnosti za sprječavanje, ublažavanje i liječenje koštane resorpcije u upalnim zbivanjima.]]></summary_hr><summary_en><![CDATA[The inflammatory arthritides are chronic joint diseases, and a major health problem because of progressive disability. The most common form is rheumatoid arthritis (RA) characterized by bone and cartilage damage leading to deformity and permanent disability. Arthritis is also a common in systemic lupus erythematosus (SLE), mostly as a non-erosive form.In RA, inflammatory and immune cells create a microenvironment that favors osteoresorption by increasing osteoclast, and suppressing osteoblast differentiation and activity. Current treatment options such as biological therapeutics may modify the course of disease, but are not able to reverse osteoresorption.The Fas/Fas ligand system is important regulator of immune system homeostasis, and there is accumulating evidence for the role of this system in the regulation of bone homeostasis. Inactivation of Fas has a bone-sparing effect, preventing bone loss upon estrogen withdrawal, as well as in inflammatory arthritides, but the exact lineages and signaling pathways mediating this effect are not defined. Using the murine model of antigen-induced arthritis (AIA) in mice deficient for Fas, and synovial fluid samples from patients with RA and SLE, we aim to identify cell populations responsible for inhibition of osteoresorption, as well as functional alterations in these populations by analysing their gene expression profiles. In addition, we expect to confirm the role of identified genes/molecules by their inactivation in vivo in the murine model of AIA, and the role of a lineage using conditional lineage-specific models of Fas-inactivation. The analysis of human samples will allow for the translation to the clinical setting. Our approach aims to identify novel cellular/molecular drivers of bone resorption in arthritis, on a lineage-specific level. Proposed studies will provide new targets for preventing, reducing, and potentially reversing the osteoresorptive process which is a consequence of inflammatory events.]]></summary_en></project><project>
<id>3323</id><title_hr><![CDATA[Oplemenjivanje pšenice na otpornost prema Fuzarijskoj paleži klasa upotpunjeno s analizama mikotoksina i antioksidativnim putevima]]></title_hr><title_en><![CDATA[Wheat breeding for resistance to Fusarium head blight combined with mycotoxin analysis and antioxidant pathways]]></title_en><user_id>273</user_id><user_firstLast_name>Valentina Španić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2014-09</proposal_call><code>UIP-2014-09-9188</code><acronim><![CDATA[Fuzarij/Fusarium]]></acronim><duration>01.06.2015 - 31.05.2018</duration><status>Završio</status><financ_value>49.996,68 eur</financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Poljoprivreda, </scie_field_hr><scie_field_en>Agriculture, </scie_field_en><institution_hr><![CDATA[Poljoprivredni institut Osijek]]></institution_hr><institution_en><![CDATA[Agricultural Institute Osijek]]></institution_en><team_members_id>432, 571, 825, 2820, 408, 51, 334, </team_members_id><team_members_names><![CDATA[Tihana Marček, Ivan Abičić, Daniela Horvat, Marijana Tucak, Kristina Habschied, Marija Viljevac Vuletić, Bojan Šarkanj, ]]></team_members_names><keywords_hr><![CDATA[pšenica, fuzarij, prinos, kvaliteta, mikotoksini, antioksidativna aktivnost]]></keywords_hr><keywords_en><![CDATA[wheat, fusarium, yield, quality, mycotoxins, antioxidative activity]]></keywords_en><summary_hr><![CDATA[Fuzarijska palež klasa (FHB), je problem vrlo raširen u svijetu, ima veliki ekonomski utjecaj na industriju žitarica jer smanjuje kvalitetu sjemena i prinosa pšenice, ali predstavlja čak i ozbiljniji problem u ljudskoj i životinjskoj ishrani jer ova gljiva proizvodi toksične sekundarne metabolite-mikotoksine. Najbolji pristup za kontrolu FHB i smanjivanje onečišćenja mikotoksinima je stvaranje genotipova pšenice koji nose gene otpornosti na FHB. Svrha ovog projekta je pronaći genotipove pšenice koji imaju određenu razinu otpornosti na FHB infekciju, a time i manje količine mikotoksina u prerađenim i neprerađenim proizvodima. Tretman makrokonidijama će se provesti na 50 genotipova ozime pšenice u vrijeme cvatnje u prvoj godini istraživanja. Učestalost i intenzitet bolesti mjerit će se u nekoliko navrata, te će se izračunati površina unutar krivulje bolesti (AUDPC). Za daljnja istraživanja odabrat će se 25 genotipova pšenice na temelju niže učestalosti i inteziteta bolesti i umjetno će se zaraziti u drugoj i trećoj godini istraživanja. U svakoj godini, nakon žetve odredit će se urod zrna, hektolitarska masa, masa 1000 zrna, sadržaj bjelančevina, sadržaj glutena, sedimentacijska vrijednost i reološki parametri pšeničnog brašna. Zato Ovim projektom će se analizirati DON, T-2 i HT-2 toksin, nivalenol, diacetoksiscirpenol, fuzarenon X i zearalenon u zrnu pšenice i pšeničnom sladu. Za dobivanje pouzdanih informacija o utjecaju umjetne infekcije na kvalitetu pšenice, potrebno je proučiti (osim kemijskih i reoloških parametara kvalitete) sastav i količinu proteina pšenice, s naglaskom na glijadine (?-, ?- ?- ) i glutenine (HMW-GS i LMW-GS). Otpornost biljaka na biotički stres izazvan patogenom provjerit će se mjerenjem aktivnosti enzima antioksidativnog sustava (gvajakol peroksidaze, askorbat peroksidaze, superoksid dismutaze, katalaze) Odredit će se i slobodni prolin i malonaldehid. ]]></summary_hr><summary_en><![CDATA[Fusarium head blight (FHB), as a global problem, has a great economic impact on the cereal industry due to reduced seed quality and yield of wheat genotypes, but even most serious problem for human and animal consumption is the capability of the fungus to produce toxic secondary metabolites-mycotoxins. The best approach to control FHB and to reduce mycotoxin contamination is to create wheat genotypes which are carrying effective resistance genes. The purpose of this project is to find the wheat genotypes that have a certain level of resistance to FHB infections. Macroconidia treatment will be carried out at 50 winter wheat genotypes at the time of flowering in the first year of investigation. Disease incidence and intensity will be measured in a couple of occasions to calculate area under disease curve. For further research 25 wheat genotypes will be selected based on the lower disease incidence and intensity and artificially inoculated in the second and third year of investigation. In each year, after harvest we will determine grain yield, test weight, 1000 kernel weight, protein content, gluten content, sedimentation value and rheological parameters of wheat flour. DON, T-2 and HT-2 toxin, nivalenol, diacetoksiscirpenol, fuzarenon X and zearalenone will be analysed in wheat grain and wheat malt. To obtain reliable information on the impact of artificial inoculation on quality of wheat genotype, it is necessary to study (except chemical and rheological parameters of quality) the composition and quantity of wheat proteins, with emphasis on gliadins (?-, ?- ?-) and glutenins (HMW-GS and LMW-GS). Several antioxidant enzymes (guaiacol peroxidase, ascorbate peroxidase, superoxide dismutase, catalase) will be screened in a few occasions in order to find their potential correlation with plant resistance mechanisms to the pathogen attack.  We will also check accumulation of free proline and malondialdehyde content.]]></summary_en></project><project>
<id>3325</id><title_hr><![CDATA[Multimodalni pristup liječenju i dugoročnom praćenju tijeka depresivnog poremećaja metodom magnetske rezonancije]]></title_hr><title_en><![CDATA[Multimodal approach to treatment and long-term assessment of depressive disorder using magnetic resonance imaging]]></title_en><user_id>5929</user_id><user_firstLast_name>Neven Henigsberg</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2014-09</proposal_call><code>IP-2014-09-2979</code><acronim><![CDATA[MODERN]]></acronim><duration>01.07.2015 - 30.09.2018</duration><status>Završio</status><financ_value>89.738,40 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Kliničke medicinske znanosti, Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Clinical sciences, Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb School of Medicine]]></institution_en><team_members_id>7379, 7226, 6534, 7272, 6466, 13608, 3662, 5845, 13578, 13598, 13480, 13311, 13496, 13563, 13637, 7381, 6937, 7225, 7090, 13638, 7088, 13652, 7333, </team_members_id><team_members_names><![CDATA[Vlado Jukić, Dragica Kozarić-Kovačić, Marko Radoš, Darko Marčinko, Antoinette Kaić-Rak, Miroslav Herceg, Dragan  Nimac, Viktorija Erdeljić Turk, Dubravka Kalinić, Dario Bagarić, Snježana Spitzmüller Šurlan, Aleksandar Savić, igor filipcic, Maja  Bajs Janović, Špiro Janović, Petrana Brečić, Helena Šarac, Zrnka Kovačić Petrović, Petra Kalember, Benedict Rak, Pero Hrabač, Tomislav Madžar, Mladen Loncar, ]]></team_members_names><keywords_hr><![CDATA[depresivni poremećaj, spektroskopija magnetskom rezonancijom, liječenje, prognoza, relaps]]></keywords_hr><keywords_en><![CDATA[depressive disoreder, magnetic resonance spectroscopy, treatment, prognosis, relapse]]></keywords_en><summary_hr><![CDATA[Cilj projektnog prijedloga je uspostaviti jedinstveni i novi pristup liječenju i dugoročnoj procjeni učinaka depresije. Koristit ćemo mrežu vodećih istraživača u područjima magnetske rezonancije, spektroskopije, tradicionalnih psihijatrijskih pristupa pacijentu i etike. Očekujemo da će rezultati projekta predstavljati značajan doprinos personaliziranom pristupu u liječenju depresije, objektivnom prikazivanju rezultata liječenja i procijeni učinaka bolesti na stanje oboljelog kao i na trošak koji predstavlja za zajednicu.]]></summary_hr><summary_en><![CDATA[The aim of the proposal is to establish a unique and novel approach to therapy and assessment of long-term effects of depression.We plan to use a network of leading researchers in the fields of magnetic resonance imaging, spectroscopy, traditional psychiatric approach and ethics.As a result, we expect to bring a major contribution to personalized approach in treatment of depression, objectivising of treatment results and assessment of effects of the disease and the treatment on the wellbeing of the individual and its cost to the society.]]></summary_en></project><project>
<id>3326</id><title_hr><![CDATA[Mjeriteljska infrastruktura za pametne mreže]]></title_hr><title_en><![CDATA[Smart Grid metrology infrastructure]]></title_en><user_id>5372</user_id><user_firstLast_name>Roman Malarić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2014-09</proposal_call><code>IP-2014-09-8826</code><acronim><![CDATA[SMAGRIMET]]></acronim><duration>25.08.2015 - 24.08.2019</duration><status>Završio</status><financ_value>127.878,43 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Elektrotehnika, Temeljne tehničke znanosti, </scie_field_hr><scie_field_en>Electrical engineering, Basic engineering sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id>4309, 3516, 5507, 142, 1484, 5389, 3230, 12749, 1370, 4942, 7406, 5483, 11130, 21319, 21317, 5165, 25330, </team_members_id><team_members_names><![CDATA[Marin Despalatović, Tonko Garma, Hrvoje Hegeduš, Marko Jurcevic, Tomislav Kilić, Petar Mostarac, Goran Petrović, Goran Majić, Dubravko Sabolić, Igor Štambuk, Ivica Kunšt, Kruno Miličević, Zeljko Martinovic , Juraj Alojzije Bosnić, Jure Konjevod, Branimir Ivšić, Antonijo Kunac, ]]></team_members_names><keywords_hr><![CDATA[Pametne mreže, mjeriteljstvo, precizne mjerne metode, mjerenje snage, mjerenje energije]]></keywords_hr><keywords_en><![CDATA[Smart grid, metrology, precise measurement methods, measurement of power, measurement of energy]]></keywords_en><summary_hr><![CDATA[Cilj ovog projekta je izgradnja nacionalne mjeriteljske infrastrukture za podršku Smart Grid tehnologiji, koja u potpunosti nedostaje u trenutnoj hrvatskoj mjeriteljskoj infrastrukturi. Nedostaje čak i nacionalni etalon za snagu i energiju. SMAGRIMET će biti glavni centar za istraživanje i razvoj potrebne mjeriteljske infrastrukture u Republici Hrvatskoj za smart grid i srodna znanstvena područja koji će učinkovito premostiti jaz između hrvatske i europske mjeriteljske infrastrukture. Većina europskih mjeriteljskih instituta sudjelovala je u projektu razvoja Smart Grid mjeriteljske infrastrukture u kojem Hrvatska nije sudjelovala zbog nedostatka infrastrukture za mjerenje snage i energije i povezanih istraživanja vezana za pametne mreže. Istraživanje u ovom projektu će biti usmjereno na razvoj vrlo preciznih naponskih i strujnih mjernih pretvornika, pomoću analogno digitalnih pretvornika i koristeći nove algoritme za preciznu analizu mjernih podataka. Ovaj istraživački projekt će adresirati niz mjeriteljskih izazova koji će pružiti neophodnu podršku kako bi se osigurala sigurnost opskrbe električnom energijom i stabilnost mreže. Izazovi su mnogi: Mjerni okvir za nadzor i stabilnost pametne mreže, sljedivost mjerenja na udaljenim lokacijama energetske infrastrukture koji osiguravaju pravednu trgovinu energijom, daljinsko mjerenje u energetskim postrojenjima i kućanstvima, kvalitetu i učinkovitost energije te modeliranje, simulacija i analiza stanja pametne mreže. Također, uvođenje novog standarda IEC 61850 će promijeniti način na koji će trafostanica funkcionirati u budućnosti, a novi izazovi i rješenja tek trebaju biti istraženi i razvijeni. ]]></summary_hr><summary_en><![CDATA[The aim of this project is to build national metrology infrastructure to support smart grid technology and research, as it is completely lacking in the current Croatian metrology infrastructure. Even, the power and energy national standard is missing.The SMAGRIMET will be main centre for research and development of necessary metrological infrastructure in Croatia for smart grid and related scientific fields that will effectively bridge the gap between the Croatian metrological infrastructure and European counterparts. Most of the European metrological institutes have contributed to the European Smart grid metrology project in which Croatia has not taken part because of the lack of infrastructure for measuring power and energy and related issues related to smart grids.The research will be focused in developing highly accurate voltage and current transducers, using precision sampling devices and using new algorithms to accurately analyse measurement data.This research project addresses a series of metrological challenges that will provide essential support to ensure security of electricity supply and grid stability, grid quality, and fair trade between commercial parties employing the grid. The challenges are many: Measurement framework for monitoring stability of smart grids, traceable on-site energy measurement systems for ensuring fair energy trade, remote on-site measurement of power quality and efficiency and modelling, simulation and network analysis of the system state of smart grids-. Also the introduction of the new standard IEC 61850 will change the way the substation will function in the future. The standard makes new challenges and solutions have yet to be researched and developed.]]></summary_en></project><project>
<id>3331</id><title_hr><![CDATA[Reprogramiranje citoprotektivnih puteva u mezoteliomu]]></title_hr><title_en><![CDATA[Reprogramming cytoprotective pathways in malignant mesothelioma]]></title_en><user_id>5915</user_id><user_firstLast_name>Sven Seiwerth</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2014-09</proposal_call><code>IP-2014-09-4173</code><acronim><![CDATA[ReprogrammingMM]]></acronim><duration>01.12.2015 - 30.11.2019</duration><status>Završio</status><financ_value>132.722,81 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Kliničke medicinske znanosti, Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Clinical sciences, Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb School of Medicine]]></institution_en><team_members_id>4853, 6755, 4991, 5270, 5078, 3422, 4867, 6223, 25311, </team_members_id><team_members_names><![CDATA[Luka Brčić, Ana Šepac, Iva Brčić, Kristina Meljanac Salopek, Hoda Mir Alireza, Marko Jakopovic, Marija Mišić, Balazs Dome, Sunčana Sikirić, ]]></team_members_names><keywords_hr><![CDATA[matične stanice, pluripotencija, reprogramiranje, mezoteliom, citoprotekcija, onkogeni]]></keywords_hr><keywords_en><![CDATA[stem cells, pluripotency, reprogramming, malignant mesothelioma, cytoprotection, oncogenes]]></keywords_en><summary_hr><![CDATA[Vjeruje se da je evolucija malignih tumora stohastički proces potaknut mutacijama koje uzrokuju aktivaciju i inaktivaciju glavnih gena kojima tumorske stanice stječu fenotipske prednosti pred normalnim stanicama što im omogućava proliferaciju, lokalnu migraciju i metastaziranje. Svježi podaci ukazuju da su neke od osnovnih značajki malignosti jednake normalnim pocesima u embrionalnom razvoju koji je programiran i precizno reguliran. Subpopulacija tumorskih stanica koja pokazuje svojstva pluripotentnih stanica, tzv. tumorske matične stanice, imaju bitnu ulogu u rezistenciji na radio- i kemoterapiju, mirovanje tumora te metastaziranje. Mi ćemo proučavati maligne karakteristike mezotelioma koje su potaknute programiranim procesima povezanim s regulacijom pluripotentnosti i koje mogu biti modificirane vanjskim djelovanjem. Opća hipoteza je da je rezistencija na oksidativni stres i kemoterapiju u stanicama mezotelioma regulirana onkogenim putem PI3K/AKT/BCL2. Istražit će se može li se ovaj put kontrolirati glavnim regulatorima pluripotencije i diferencijacije uz pomoć reprogramiranja. Stanice mezotelioma će se reprogramirati u pluripotentno stanje uvođenjem specifičnih čimbenika tvoreći inducirane pluripotentne mezoteliomske matične stanice. Dobivene stanice će se diferencirati u tri linije. Ovo će nam omogućiti da odredimo može li ovakva eksperimentalna perturbacija smanjti aktivnost onkogenog puta PI3K/AKT/BCL2 koji bi mogao kontrolirati mitohondrijske citoprotektivne puteve. Konačno takva intervencija može stanice učiniti osjetljivijima na oksidativni stres i kemoterapeutike. In vitro studije će biti poduprijete s klinički relevantnim histopatološkim ispitivanjem tumora pacijenata u kojem ćemo usporediti diferencijacijski status, aktivnost PI3K/AKT/BCL2 puta i preživljenje pacijenata. ]]></summary_hr><summary_en><![CDATA[It is generally believed that the evolution of a cancer is a stochastic process of mutation-induced activation and inactivation of principal genes by which tumor cells acquire phenotypic advantages over normal cells allowing them to proliferate and migrate locally and to remote organs. Recent data indicate that some of key features of malignancy are similar to normal processes of embryonic development, which are programmed and highly regulated. The subpopulation of cancer cells that exhibit properties of embryonic stem cells are called cancer stem cells (CSCs) and studies showed their essential role in resistance to radio- and chemotherapy, tumor dormancy and metastasizing. We aim to investigate malignant characteristics of mesothelioma that are driven by programmed processes associated with the regulation of pluripotency, and which can be modified by exogenous treatment. Our overall hypothesis is that the resistance to oxidative stress and chemotherapeutics in mesothelioma cells is regulated by the activity of oncogenic pathway PI3K/AKT/BCL2. It will be investigated whether this pathway can be controlled with master regulators of pluripotency and differentiation by reprogramming mesothelioma cells. Mesothelioma cells will be reprogrammed to pluripotent state with introduction of defined factors yielding induced pluripotent mesothelioma stem cells (iPMSCs). iPMSCs will be differentiated into three different lineages. This will allow us to determine whether such experimental perturbation decreases activity of the specific oncogenic pathway PI3K/AKT/BCL2 that may control mitochondrial cytoprotective pathways. Ultimately such intervention may render cells more sensitive to oxidative stress and chemotherapeutics. In vitro studies will be corroborated with clinically relevant histopathological examination of patient’s tumors where correlation among differentiation status, PI3K/AKT/BCL2 pathway activity and patient’s survival will be examined. ]]></summary_en></project><project>
<id>3333</id><title_hr><![CDATA[Novi, učinkoviti iteracijski postupak proračuna konstrukcija - poopćenje suvremenih postupaka]]></title_hr><title_en><![CDATA[ Novel, Efficient Iterative Procedure for the Structural Analysis - Generalisation of Modern Methods]]></title_en><user_id>13097</user_id><user_firstLast_name>Damir Lazarević</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2014-09</proposal_call><code>IP-2014-09-2899</code><acronim><![CDATA[YODA]]></acronim><duration>01.09.2015 - 31.08.2019</duration><status>Završio</status><financ_value>78.518,68 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Temeljne tehničke znanosti, Građevinarstvo, </scie_field_hr><scie_field_en>Basic engineering sciences, Civil engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Građevinski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Civil Engineering]]></institution_en><team_members_id>13251, 13695, 13254, 12842, 13267, 21063, </team_members_id><team_members_names><![CDATA[Josip Dvornik, Krešimir Fresl, Antonia Jaguljnjak Lazarević, Mario Uroš, Petra Gidak, Elizabeta Šamec, ]]></team_members_names><keywords_hr><![CDATA[brza iteracijska metoda, Ritzova metoda, štedni zapis matrice, ocjena točnosti, poopćenje iteracijskih postupaka]]></keywords_hr><keywords_en><![CDATA[fast iterative method, Ritz method, sparse matrix storage, accuracy estimate, generalization of iterative methods]]></keywords_en><summary_hr><![CDATA[Zamisao je projekta razviti brzi iteracijski postupak proračuna konstrukcija koji je za jednaki utrošak memorije brži, a za nešto veći utrošak memorije izrazito brži od suvremenih izravnih i iteracijskih postupaka proračuna. Postupak koji predlažemo ima i dodatnu važnost jer se većina suvremenih iteracijskih postupaka može prikazati kao poseban slučaj našeg postupka pa ga možemo smatrati poopćenjem većine suvremenih iteracijskih postupaka. Ukratko, radi se zapravo o iteracijskom postupku kod kojega se u svakom koraku iteracije primjenjuje diskretna Ritzova metoda. U svakom se koraku generiraju koordinatni vektori koji tvore podprostor unutar kojega se traži lokalni minimum energije čime se ukupna energija smanjuje i konvergira traženom minimumu. Broj koordinatnih vektora (dimenzija podprostora) nije ograničen, ali teži se tomu da bude što manji – puno manji od broja nepoznanica. Generiranje kvalitetnog podprostora - koordinatnih vektora središnji je problem kojiunutar projekta treba riješiti. Uglavnom, metodom koju predlažemo moguće je kombinirati dobra svojstva nekoliko iteracijskih postupaka istodobno. Štoviše, svaki novi postupak generiranja vektora otvara mogućnost ubrzanja našeg postupka. Nadalje, svojstvo konjugiranosti na kojemu se temelje neki iteracijski postupci i koje vrijedi samo u linearnim problemima, u našem slučaju nije nužno potrebno pa se metoda može uspješno primijeniti i u nelinearnim proračunima kod kojih svojstvo konjugiranosti uopće nije definirano. Tada se za praktične primjere isključivo koriste iteracijski postupci proračuna. Konačno, primjenom naših, izvornih, metoda cjelobrojne aritmetike, možemo odrediti točno rješenje prikladnih, praksi realnijih (ne samo trivijalnih, tzv. benchmark) primjera pa možemo ocijeniti konvergenciju, stabilnost i točnost bilo kojeg numeričkog pa i našeg postupka.]]></summary_hr><summary_en><![CDATA[The idea of the project is to develop a fast iterative method for structural analysis which is, in the case of equal memory usage, faster and for larger memory usage, much faster than modern direct and iterative solvers. The procedure that we propose has additional importance, because the majority of modern iterative methods can be represented as a special case of our procedure. Therefore, it can be considered as a generalization of most modern iterative methods. In brief, it is actually an iterative procedure in which at each iteration step, discrete Ritz method is applied. At every step, coordinate vectors which form a subspace are generated, within which local energy minimum is sought, thus decreasing the total energy of the system, which therefore converges to the required minimum. The number of coordinate vectors (subspace dimension) is not limited, but aims to be small - much smaller than the number of unknowns. How to generate a good subspace - coordinate vectors is the central problem the project needs to address. Basically, with the method proposed it is possible to combine the good properties of several iterative methods simultaneously. Furthermore, every new vector generation procedure opens the possibility to fasten our method. Additionally, the property of conjugacy which underlies some iterative procedures and which is valid only in linear problems, in our case is not absolutely necessary. Therefore, the method can be successfully applied in nonlinear calculations in which the conjugacy is not even defined. This fact is really important, because in the case of nonlinear practical applications, iterative methods are used exclusively. Finally, applying our original method based on integer arithmetic, the exact solution of appropriate, practical, realistic (not just simple, benchmark) examples can be determined, so we can evaluate the convergence, stability and accuracy of any numerical procedure, including the method proposed.]]></summary_en></project><project>
<id>3337</id><title_hr><![CDATA[Novi metal-organski sustavi s oksalatnim i kinoidnim ligandima s podešenim svojstvima pogodnim za primjenu]]></title_hr><title_en><![CDATA[Novel metal-organic systems based on the oxalate and quinoid ligands with tuned properties suitable for applications]]></title_en><user_id>13343</user_id><user_firstLast_name>Krešimir Molčanov</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2014-09</proposal_call><code>IP-2014-09-4079</code><acronim><![CDATA[NMOSBOQLWTPSFP]]></acronim><duration>01.05.2015 - 30.04.2019</duration><status>Završio</status><financ_value>121.136,11 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, Fizika, </scie_field_hr><scie_field_en>Chemistry, Physics, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>12831, 11146, 13002, 12971, 21308, 21309, </team_members_id><team_members_names><![CDATA[Marijana Jurić, Jasminka Popovic, Martina Vrankić, Lidija Androš, Lidija Kanižaj, Valentina Milašinović, ]]></team_members_names><keywords_hr><![CDATA[funkcionalni materijali, kristalno inženjerstvo, kristalna struktura, magnetska svojstva, koordinacijski polimeri, miješani oksidi, oksalati, kinoni]]></keywords_hr><keywords_en><![CDATA[functional materials, crystal engineering, crystal structure, magnetic properties, coordination polymers, mixed metal oxides, oxalates, quinones]]></keywords_en><summary_hr><![CDATA[Cilj projekta je učinkovit i postupan dizajn novih i naprednih funkcionalnih materijala temeljenih na metal-organskim kompleksima. Kombinacijom metalnih centara s polidentatnim organskim ligandima dobivaju se strukturno raznolike rešetke različitih magnetskih električnih, termičkih, optičkih i drugih svojstava. U predloženom projektu, dva analogna premošćujuća liganda, oksalat i supstituirani 2,5-dihidroksikinonat (DHQ), koristit će se u pripravi koordinacijskih polimera različite dimenzionalnosti i topologije. Njihove interakcije s prijelaznim metalnim kationima obuhvaćaju različita magnetska svojstva, koje se mogu mijenjati izborom točno određenih strukturnih fragmenata. Oksalatni kompleksi će se istraživati ne samo kao mogući magnetski materijali s uređenjem pri određenoj temperaturi, nego kao i prekursori za pripravu tehnološki važnih miješanih metalnih oksida termičkom razgradnjom u jednom koraku. Ova metoda priprave oksida, u odnosu na standardne reakcije u čvrstom stanju, ima nekoliko prednosti: kraća termička obrada na nižoj temperaturi, nema ponavljanja postupaka mljevenja, a produkti su homogeniji. DHQ-kompleksi proučavat će se zbog njihovog potencijala za prijenos naboja, što bi moglo dovesti do materijala s reverzibilnim magnetskim prijelazom. Također, obećavajuća skupina liganada su stabilni semikinonski radikali, dobiveni iz različito supstituiranih DHQ-ova. Njihovi su kompleksi s prijelaznim metalima do sada malo poznati i nisu bili korišteni za izradu funkcionalnih materijala. Interdisciplinarnost projekta zahtjeva različite metode za karakterizaciju ovih naprednih materijala: difrakciju rendgenskih zraka na monokristalu i prahu, uključujući određivanje gustoće naboja, termičku analizu (TG / DTA), IR-, UV/Vis- i EPR-spektroskopiju, itd. Dobiveni će se rezultati koristiti za povezivanje njihovih struktura i svojstava.]]></summary_hr><summary_en><![CDATA[The project targets at efficient and progressive design of novel and advanced functional materials based on metal-organic complexes. Combination of metal centres with polydentate organic ligands provide colossal, structurally-diverse, platforms possessing a variety of magnetic, electrical, thermal, optical and other properties. In the proposed project, two analogue bridging ligands, oxalate and substituted 2,5-dihydroxyquinonate (DHQ), will be used in the preparation of the coordination polymers of different dimensionality and topology. Their interactions with transition metal cations involve a variety of magnetic phenomena, which can be tuned by highly sensitive selection of structural fragments. The oxalate-based complexes will be studied not only as potential magnetic materials ordering at a certain temperature, but also as the single-source precursors for the preparation of technologically important mixed-metal oxides through the thermal decomposition process. This method of preparing oxides, as compared to conventional solid-state reactions, has several advantages: shorter thermal treatment at lower temperature, without repeating grinding procedures, and the products are more homogeneous. The DHQ complexes will be studied due to their potential for charge transfer, which may lead to materials with reversible magnetic transition. Also, promising class of the ligands are stable semiquinone radicals derived from variously substituted DHQs. So far, their complexes with transition metals are little-known and have not been exploited for design of functional materials.The interdisciplinary nature of the project requires a variety of methods to characterise these advanced materials: single-crystal and powder X-ray diffractions including X-ray charge density studies, thermal analyses (TG/DTA), IR, UV/Vis and EPR spectroscopies, etc. The results obtained will be used to correlate their structure and properties.]]></summary_en></project><project>
<id>3338</id><title_hr><![CDATA[Kredni geodinamski dokazi u području Dinarida i Panonskog bazena]]></title_hr><title_en><![CDATA[Cretaceous GEOdynamic PROOFS in the Dinarides and Pannonian Basin]]></title_en><user_id>9942</user_id><user_firstLast_name>Dražen Balen</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2014-09</proposal_call><code>IP-2014-09-9541</code><acronim><![CDATA[GEOPROOFS]]></acronim><duration>01.06.2015 - 31.05.2019</duration><status>Završio</status><financ_value>117.295,11 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Geologija, </scie_field_hr><scie_field_en>Geology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>1404, 13375, 7702, 12953, 13066, 13340, 13393, 3166, 13363, 13361, 3920, 23142, </team_members_id><team_members_names><![CDATA[Darko Tibljaš, Davor Pavelić, Bruno Tomljenović, Igor Vlahović, Ivo Velić, Blanka Cvetko Tešović, Marijan Kovačić, Borna Lužar-Oberiter, Zorica Petrinec, Frane Marković, Maja Martinuš, Petra Schneider, ]]></team_members_names><keywords_hr><![CDATA[kreda, geodinamika, procesi, Dinaridi, Panonski bazen]]></keywords_hr><keywords_en><![CDATA[Cretaceous, geodynamics, processes, Dinarides, Pannonian Basin]]></keywords_en><summary_hr><![CDATA[Izuzetno složeni geološki sustav koji obuhvaća Dinaride, kristalinsku podlogu Panonskog bazena te njihova okolna područja jedno je od znanstveno najintrigantnijih područja Europe. U periodu krede, posebno na granici gornje i donje krede, značajni odjeci geodinamskih procesa koji su se odvijali na globalnoj razini identificirani su u stijenama kristalinske podloge, kao i u sinorogenetskim klastičnim sedimentima, ali i u sedimentnom zapisu ranije vrlo stabilne karbonatne platforme. Detaljno istraživanje te definiranje kristalinskih stijena različitih krednih starosti, njihovo porijeklo i način pojavljivanja, zajedno s istraživanjem brojnih i raznolikih klastičnih formacija koje pripadaju slijedu taložnih bazena nastalih u različitim tektonskim okolišima, razotkrit će trenutno prikrivene odnose između magmatskih, metamorfnih i sedimentnih procesa i tektonskih zbivanja. Ta su tektonska zbivanja rezultat međuovisne (geo)dinamske evolucije velikih tektonskih jedinica koje su pripadale promatranom području u vrijeme krede. Dobiveni će podaci biti upotpunjeni analizom raznolikosti facijesa koja je ostala zabilježena u gornjokrednom slijedu Krških Dinarida.Predloženi će projekt biti realiziran kroz paralelna terenska, kabinetska i laboratorijska istraživanja, korištenjem suvremenih metoda i postupaka istraživanja koje će provoditi tri dijelom preklapajuće radne skupine u stalnoj interakciji. One će biti usmjerene na istraživanja kristalinske podloge, sedimentološka istraživanja okolnih/obližnjih klastičnih taložnih bazena te na istraživanje varijabilnosti istovremenih okoliša karbonatne platforme. Prikupljeni će podaci značajno doprinijeti rekonstrukciji geodinamske evolucije Dinaridsko-alpsko-panonskog područja kao cjeline. U tom bi kontekstu rezultati prikupljeni ovakvim složenim i  multidisciplinarnim pristupom bili od općeg interesa za sve koji se bave geološkom prošlosti alpinske Europe, kao i današnjeg Dinaridsko-alpsko-panonskog područja.]]></summary_hr><summary_en><![CDATA[The extremely complex geological system encompassing the Dinarides, Pannonian Basin crystalline basement, and their adjoining areas, is among the scientifically most intriguing areas in Europe. In the Cretaceous period, especially at the Early and Late Cretaceous time boundary, significant echoes of large-scale geodynamic process(es) have been identified in the geological record within crystalline basement rocks, as well as in clastic synorogenic sediments, and even on the previously very stable carbonate platform. Meticulous investigation and recognition of the characteristics of crystalline rocks of different Cretaceous ages, origin and occurrence, along with the investigation of numerous distinct clastic formations belonging to successive basins from different tectonic environments will reveal the presently obscured interrelations among igneous, metamorphic, sedimentary processes and tectonic events. These events are the result of interdependent evolutionary dynamics of large tectonic units belonging to the investigated area during Cretaceous. The obtained data will be complemented by analysis of the facies variability recorded within the Upper Cretaceous successions of the Karst Dinarides.The proposed project will be conducted by parallel field work, cabinet and laboratory research and performed through up-to-date methods and investigation procedures of three partly overlapping and continuously interacting working groups devoted to crystalline basement research, sedimentary research of neighboring clastic basins, and the study of variable penecontemporaneous environments of the carbonate platform realm. The collected data will considerably contribute to the reconstruction of the geodynamic evolution of the Dinaridic-Alpine-Pannonian realm as a whole. As such, the results revealed by the complex, multidisciplinary insight would be of general interest for those dealing with the geological history of Alpine Europe and the present Dinaridic-Alpine-Pannonian realm.]]></summary_en></project><project>
<id>3340</id><title_hr><![CDATA[Održivi razvoj inovacije u hrani - valorizacija otpada masline]]></title_hr><title_en><![CDATA[Valorization of olive waste in sustainable food  innovation]]></title_en><user_id>3927</user_id><user_firstLast_name>Dubravka Vitali Čepo</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2014-09</proposal_call><code>UIP-2014-09-9143</code><acronim><![CDATA[NutriOliWa]]></acronim><duration>15.09.2015 - 14.09.2018</duration><status>Završio</status><financ_value>46.917,51 eur</financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Prehrambena tehnologija, Biotehnologija, Prehrambena tehnologija, Nutricionizam, </scie_field_hr><scie_field_en>Food technology, Biotechnology, Food technology, Nutrition, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Farmaceutsko-biokemijski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Pharmacy and Biochemistry]]></institution_en><team_members_id>3517, 3915, 4167, 448, 21380, 21381, </team_members_id><team_members_names><![CDATA[Marija Grdić Rajković, Mario Jug, Marijana Zovko Končić, Suzana Rimac Brnčić, Kristina Radić, Sanja Jurmanović, ]]></team_members_names><keywords_hr><![CDATA[otpad masline, održivi razvoj,  dodatak prehrani, antioksidans, bioraspoloživost, polifenoli]]></keywords_hr><keywords_en><![CDATA[olive waste, sustainable development, antioxidant, food supplement, bioavailability, polyphenols]]></keywords_en><summary_hr><![CDATA[Direktno odlaganje u okoliš otpada koji zaostaje nakon proizvodnje maslinovog ulja, veliki je ekološki problem. Ponovno iskorištavanje otpada masline u samom je začetku te njen potencijal, kao polazne sirovine, još uvijek nije ni izbliza iskorišten. Polifenoli u otpadu masline prepoznati su kao visokovrijedni spojevi no usprkos velikom broju bioloških učinaka, njihova primjena u područjima funkcionalne hrane i dodataka prehrani kao i daljnja istraživanja njihove bološke učinkovitosti vrlo su ograničena. Glavnih razlozi tome su nedostatak prihvatljivih metoda izolacije; te loša kvaliteta i karakterizacija postojećih ekstrakta što dodatno ograničava njihovu širu primjenu i istraživanje. Stoga su glavni ciljevi projekta:1. razviti učinkovit i ekološki prihvatljiv postupak ekstrakcije polifenola iz komine masline korištenjem suvremenih, nekonvencionalnih tehnika kao što su primjena ultrazvuka ili mikrovalova, zasebno ili u kombinaciji s procesom mikroenkapsulacije. 2. razviti inovativne i održive protokole formulacije visokokvalitetnog krutog ekstrakta korištenjem inovativnih tehnoloških i metodoloških pristupa 3. provesti funkcionalnu karakterizaciju dobivenih ekstrakata korištenjem suvremenih in vitro metodoloških pristupa (antioksidacijska aktivnost u modelima hrane, bioraspoloživost, apsorpcija i metabolizam polifenola iz čvrstih ekstrakta, biološka učinkovitost) Osim što će pružiti nove znanstvene spoznaje te mogu poslužiti kao izvrstan temelj za daljnja znanstvena istraživanja specifičnih bioloških učinaka, rezultati ovog projekta nalaze i vrlo konkretnu primjenu u okvirima prehrambene- i farmaceutske industrije. U širem smislu, rezultati ovog projekta pružit će bitan doprinos kvaliteti upravljanja otpadom iz agro-prehrambenog sektora što će rezultirati značajnom ekološkom i ekonomskom korišću u budućnosti.  ]]></summary_hr><summary_en><![CDATA[The olive oil industry gives place to vast amounts of residues and when discarded untreated directly to the environment, they present a major ecological issue. Although some of these residues are beginning  to be managed to a certain extent, higher benefits should be obtained from these materials. Polyphenols abundant in olive waste have been recognized as compounds of high added value but due to the lack of efficient methods of isolation; significant variations in quality of available extracts and lack of their chemical characterization, the possibilities of further investigation of their health related properties  and utilization in the segment of functional foods or dietary supplements is very limited. The major goals of this projects are:1. to develop sustainable procedure for the extraction of polyphenols from olive waste by using unconventional extraction techniques such as ultratrasound- and microwave assisted extraction, alone or in combination with microencapsulation. That should provide significant advantages over the traditional extractions methods 2. to develop efficient drying procedure for obtaining crude olive pomace extracts (COPE) using contemporary methodological approaches with satisfactory physico-chemical properties, organoleptic characteristics and increased shelf-life. 3. to provide functional characterization of COPE using contemporary methodological approaches (bioavailability and absorption of active compounds from COPE, antioxidant activity in food model systems and biological activity)In addition to providing novel scientific knowledge and serve as the excellent starting point for further scientific investigations of particular biological activities, the results of this project have great potential to be further used by food- and pharmaceutical industry. Also, in broader sense, obtained results will contribute to the meaningful management of olive mill waste resulting with both economical and ecological benefit in the future.]]></summary_en></project><project>
<id>3345</id><title_hr><![CDATA[Obrazovne aspiracije učenika u prijelaznim razdobljima hrvatskog osnovnoškolskog obrazovanja: priroda, odrednice i promjene]]></title_hr><title_en><![CDATA[Educational Aspirations of Pupils at Transitional Periods of Croatian Elementary Education: Nature, Determinants and Change]]></title_en><user_id>861</user_id><user_firstLast_name>Boris Jokić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2014-09</proposal_call><code>UIP-2014-09-6757</code><acronim><![CDATA[COBRAS]]></acronim><duration>01.02.2016 - 31.01.2019</duration><status>Završio</status><financ_value>36.961,96 eur</financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Psihologija, </scie_field_hr><scie_field_en>Psychology, </scie_field_en><institution_hr><![CDATA[Institut za društvena istraživanja]]></institution_hr><institution_en><![CDATA[Institute for Social Research in Zagreb]]></institution_en><team_members_id>862, 7765, 12779, 12645, 12642, 21232, 21221, </team_members_id><team_members_names><![CDATA[Zrinka Ristić Dedić, Iris Marušić, Gordana Kuterovac Jagodić, Jelena Matić, Inja Erceg Jugović, Iva Košutić, Josip Šabić, ]]></team_members_names><keywords_hr><![CDATA[obrazovne aspiracije, učeničke perspektive, prijelazna obrazovna razdoblja, longitudinalno istraživanje, integrirani nacrt miješanog modela]]></keywords_hr><keywords_en><![CDATA[educational aspirations, pupil perspective, transitional periods in education, longitudinal study, fully integrated mixed model design]]></keywords_en><summary_hr><![CDATA[S ciljem istraživanja prirode, odrednica i promjena obrazovnih aspiracija učenika u prijelaznim razdobljima hrvatskog osnovnoškolskog obrazovanja, u projektu se primjenjuje longitudinalni integrirani nacrt miješanog modela u kojem se kombiniraju kvalitativne i kvantitativne metode prikupljanja podataka. Obrazovne aspiracije se definiraju kao ambicije i ciljevi učenika u vezi s neposrednim i budućim obrazovnim ishodima. Unutar postavljenog konceptualnog okvira, obrazovne aspiracije se smještaju u središte ekološkog sustava koji seže od neposredne razine pojedinog učenika, preko razine roditelja do udaljenijih razina razreda (vršnjaka) i škole. Za svaku razinu su određeni psihologijski koncepti kojima se ispituju priroda i odrednice obrazovnih aspiracija. Projekt je usmjeren na istraživanje obrazovnih aspiracija učenika iz tri kohorte u tri prijelazna razdoblja osnovnoškolskog obrazovanja: ulazak u osnovnoškolsko obrazovanje (od 1. do 2. razreda), prijelaz s razredne na predmetnu nastavu (od 4. do 5. razreda) i završavanje osnovnoškolskog obrazovanja, prije prelaska u srednjoškolsko obrazovanje (od 7. do 8. razreda). Kvalitativna faza istraživanja obuhvaća dubinsko istraživanje obrazovnih aspiracija nizom polu-strukturiranih intervjua s trijadama sudionika koje se sastoje od učenika, njegovog roditelja i učitelja. U ovoj istraživačkoj fazi, u svakoj od pet izabranih škola bit će praćene 24 trijade tijekom dvije školske godine. Kvantitativna faza istraživanja, čiji je cilj modeliranje odrednica i promjena učeničkih obrazovnih aspiracija, uključuje ponavljanu primjenu upitnika na učenicima 20 zagrebačkih osnovnih škola. U svakoj školi, svi će učenici 4. i 7. razreda biti pozvani na sudjelovanje u tri točke mjerenja tijekom dvije školske godine. Rezultati iz obje istraživačke faze bit će integrirani istovremenim razmatranjem individualnih perspektiva tijekom vremena i korištenjem postupaka statističkog modeliranja na velikim uzorcima. ]]></summary_hr><summary_en><![CDATA[In order to investigate the nature, determinants and change in pupils’ educational aspirations at transitional periods of Croatian elementary education, the project employs a longitudinal fully integrated mixed model design, using both qualitative and quantitative methods. Educational aspirations are defined as the ambitions and goals pupils hold concerning both immediate and future educational outcomes. Within conceptual framework, educational aspirations are placed at the centre of an ecological system extending from the most proximal levels of the individual pupil, through the level of parents to the more distant levels of class (peers) and school. For each level, psychological concepts are selected in order to investigate the nature and determinants of pupils’ aspirations. The research focuses on the aspirations of pupils from three different cohorts at three transitional periods of elementary education: the introduction to elementary education (1st to 2nd grade), the transition from class to subject teaching (4th to 5th) and the completion of elementary education prior to the transition to secondary education (7th to 8th). The qualitative research phase centres on an in-depth exploration of educational aspirations through a series of semi-structured interviews with participant triads made up of a pupil, his parent and teacher. In this research phase, 24 triads in each of five participating schools will be followed over two academic years. The quantitative phase consists of the repeated administration of a pupil questionnaire in 20 randomly selected schools in Zagreb aimed at examining determinants of and change in pupils’ educational aspirations. In each school, all 4th and 7th grade pupils will be invited to participate at three different time-points over two academic years. The results from both research phases will be integrated through a concurrent examination of individual perspectives over time and the use of statistical modelling from the large samples.]]></summary_en></project><project>
<id>3348</id><title_hr><![CDATA[Modeliranje okolišnih aspekata napredne obrade voda za razgradnju prioritetnih onečišćivala]]></title_hr><title_en><![CDATA[Modeling of Environmental Aspects of Advanced Water Treatment for Degradation of Priority Pollutants]]></title_en><user_id>1298</user_id><user_firstLast_name>Tomislav Bolanča</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2014-09</proposal_call><code>IP-2014-09-7992</code><acronim><![CDATA[MEAoWT]]></acronim><duration>01.09.2015 - 31.08.2019</duration><status>Završio</status><financ_value>128.104,05 eur</financ_value><scie_area_hr>Tehničke znanosti, Prirodne znanosti, </scie_area_hr><scie_area_en>Technological sciences, Natural sciences, </scie_area_en><scie_field_hr>Kemijsko inženjerstvo, Kemija, Temeljne tehničke znanosti, </scie_field_hr><scie_field_en>Chemical engineering, Chemistry, Basic engineering sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet kemijskog inženjerstva i tehnologije]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Chemical Engineering and Technology]]></institution_en><team_members_id>1122, 6112, 4661, 4674, 1123, 6729, 20856, 25242, </team_members_id><team_members_names><![CDATA[Ana Lončarić Božić, Marko Rogosic, Šime Ukić, Mirjana Novak, Daria Juretić, Bakhtiyor Rasulev, Matija Cvetnić, Antonija Tomić, ]]></team_members_names><keywords_hr><![CDATA[prioritetna onečišćivala, napredni procesi obrade voda, okolišni aspekti, mehanističko modeliranje, molekulsko modeliranje]]></keywords_hr><keywords_en><![CDATA[priority pollutants, advanced water treatment, environmental aspects, mechanistic modeling, molecular modeling]]></keywords_en><summary_hr><![CDATA[Voda je ključni resurs za čovječanstvo koji stvara i održava ekonomski rast i prosperitet. Europska Okvirna direktiva o vodama postavlja strategiju o onečišćenju voda u EU i uključuje listu prioritetnih tvari koje predstavljaju značajan rizik za vodni okoliš. Konvencionalne tehnologije obrade voda većinom se temelje na fizikalnim i biološkim procesima koji nisu adekvatni za učinkovito uklanjanje prioritetnih tvari. Stoga, razvoj održivih tehnologija obrade voda zahtijeva primjenu naprednih kemijskih procesa. Iako je konverzija onečišćivala glavni kriterij u ocjeni učinkovitosti obrade, okolišni aspekti primijenjene tehnologije odnose se na ukupnu kvalitetu obrađene vode koja se može izraziti putem sumarnih ekoloških pokazatelja kvalitete voda. Glavni cilj projekta MEAoWT je predložiti održivu tehnologiju za obradu voda koje sadrže prioritetna onečišćivala (farmaceutike i pesticide) te pružiti metodologiju za predviđanje okolišnih aspekata primijenjene tehnologije koja će služiti kao alat za procjenu kvalitete voda i kontrolu onečišćenja. U tu svrhu, za razgradnju odabranih prioritetnih onečišćivala u vodi primijenit će se UV/H2O2, UV/S2O82- i ferat (VI) oksidacijski procesi. Eksperimentalni će se podaci koristiti za izradu modela kombinirajući statističke, matematičke, mehanističke i strukturne pristupe, koristeći napredne računalne alate. Strukturne karakteristike onečišćivala u vodi, mehanizmi i kinetika razgradnje kao i radni parametri procesa obrade korelirat će se s kvalitetom obrađene vode izražene preko sumarnih ekoloških pokazatelja. Predložit će se metodologija za predviđanje, procjenu i kontrolu okolišnih aspekata tehnologije za obradu voda.]]></summary_hr><summary_en><![CDATA[Water is a crucial resource for humanity, generating and sustaining economic growth and prosperity. The European Water Framework Directive lays the EU water pollution strategy, and includes a list of priority substances which represent a significant risk to aquatic environment. The conventional water treatment technologies rely mostly on physical and biological processes which seem to be inadequate for effective removal of priority substances. Therefore, development of sustainable water treatment technologies requires the application of advanced chemical processes. Although the conversion of pollutants is main criterion in evaluation of treatment efficiency, the environmental aspects of applied technology are related to the overall quality of treated water which can be expressed in the terms of ecological sum-parameters. The main goal of MEAoWT project is to propose sustainable technology for the treatment of water containing priority pollutants (pharmaceuticals and pesticides) and to provide the methodology for the prediction of environmental aspects of applied technology, as a powerful tool for water quality assessment and pollution control. For that purpose UV/H2O2, UV/S2O82- and ferrate(VI) oxidation processes will be applied for the degradation of selected priority pollutants in water. Experimental data will be used for development of models combining statistical, mathematical, mechanistic and structural approaches using advanced computational tools. Structural characteristics of water pollutants, degradation mechanisms and kinetics as well as operating parameters of treatment processes will be correlated with the quality of treated water in terms of ecological sum-parameters. The methodology for prediction, assessment and control of the environmental aspects of water treatment technology will be proposed.]]></summary_en></project><project>
<id>3350</id><title_hr><![CDATA[Ekonomske teškoće obitelji, psihosocijalni problemi i obrazovni ishodi adolescenata u vrijeme ekonomske krize]]></title_hr><title_en><![CDATA[Family economic hardship, psychosocial problems and educational outcomes of adolescents in the time of economic crisis ]]></title_en><user_id>13038</user_id><user_firstLast_name>Marina Ajduković</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2014-09</proposal_call><code>IP-2014-09-8546</code><acronim><![CDATA[FEHAP]]></acronim><duration>10.09.2015 - 09.01.2020</duration><status>Završio</status><financ_value>67.079,00 eur</financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Socijalne djelatnosti, Sociologija, Psihologija, </scie_field_hr><scie_field_en>Social work, Sociology, Psychology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Pravni fakultet u Zagrebu]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Law]]></institution_en><team_members_id>13253, 7769, 13047, 13049, 12879, 12829, 12881, 12853, 12956, 18962, 24348, </team_members_id><team_members_names><![CDATA[Ivan Rimac, Gordana Keresteš, Olja Družić Ljubotina, Marijana Kletečki Radović, Linda Rajhvajn Bulat, Lea Skokandić, Nika Sušac, Jelena Ogresta, Miroslav Rajter, Ines Rezo, Petra Kožljan, ]]></team_members_names><keywords_hr><![CDATA[adolescenti,ekonomske teškoće obitelji,rizik siromaštva,eksternalizirani problemi,internalizirani problemi,rizična ponašanja,napuštanje školovanja]]></keywords_hr><keywords_en><![CDATA[adolescents, family economic hardship, risk of poverty, externalized problems, internalized problems, risk behaviours, dropping out of school]]></keywords_en><summary_hr><![CDATA[Cilj projekta je povećati razumijevanje učinaka ekonomskih teškoća obitelji na psihosocijalne i obrazovne probleme adolescenata u vrijeme nacionalne ekonomske krize. Novi integrativni model utjecaja ekonomskih poteškoća obitelji na razvoj adolescenta (IMEPO) će biti provjeren kroz longitudinalni kvantitativni i kvalitativni nacrt istraživanja. Istraživački problemi su: (1) Procijeniti ukupni i individualni doprinos prediktora u IMEPO na psihosocijalni razvoj adolescenata, gdje su kriteriji internalizirani i eksternalizirani problemi, druga rizična ponašanja (konzumacija alkohola i droga, kockanje i rizične seksualne aktivnosti) i obrazovni ishodi, uključujući napuštanje obrazovanja, (2) Usporediti uspješnost dva modela – osnovnog modela financijskog stresa (FSM) i novog IMEPO – u predviđanju psihosocijalnih i obrazovnih problema u razvoju mladića i djevojaka, (3) Utvrditi potencijalne rizične i zaštitne čimbenike koji moderiraju odnos između ekonomskih poteškoća obitelji i psihosocijalnih problema adolescenata te njihovih obrazovnih ishoda, (4) Ispitati promjene psihosocijalnih rizika i problema u školskom postignuću tijekom adolescencije, (5) Ispitati obrasce ranog napuštanja srednjoškolskog obrazovanja te steći dublje razumijevanje procesa i čimbenika koji vode ka napuštanju srednje škole.Učenike će se pratiti u tri točke mjerenja (I, II i III razred). Koristiti će se dvo-etapni neproporcionalno stratificirani klaster uzorak koji će obuhvatiti približno 1200 srednjoškolaca i njihovih majki/skrbnica. Istraživanje će se provesti u 6 županija središnje Hrvatske različitog ekonomskog statusa. Metodom namjernog uzorka bit će odabrano 40 učenika iz početnog uzorka koji su u promatranom razdoblju napustili srednjoškolsko obrazovanje. Ishodi projekta će se moći iskoristiti za daljnje razvijanje mjera socijalne i obiteljske politike usmjerenih prema smanjivanju negativnih učinaka ekonomskih teškoća na obitelji, obiteljske odnose i probleme prilagodbe adolescenata.]]></summary_hr><summary_en><![CDATA[Aim of the project is to advance the understanding of effects of family economic hardship on adolescents’ psychosocial and educational problems at a time of a nationwide economic crisis. A new integrative model of impact of family economic hardship (IMFEH) will be tested in a longitudinal quantitative and qualitative research design. The objectives are: (1) To assess the overall and individual contribution of predictors in IMFEH on adolescents&#39; psychosocial development, where internalized problems, externalized problems, other risk behaviours (alcohol and drug abuse, gambling, risk sexual behaviours) and educational outcomes, including dropp-out, will serve as criterion variables, (2) To compare the efficiency of two models – initial family stress model (FSM) and new IMFEH – in predicting psychosocial and educational problems in the development of male and female adolescents, (3) To identify potential risk and protective factors that moderate the relationship between family economic hardship and adolescents&#39; psychosocial problems and educational outcomes, (4) To investigate the changes in psychosocial risks and school achievement problems during adolescence, and (5) To explore patterns of early leaving secondary education and gain deeper understanding of the process and factors that lead to dropping out of secondary school. Pupils will be followed through 3 waves of data collection (1st, 2nd and 3rd grade). A two-stage disproportionally stratified cluster sample, which will include approximately 1200 pupils and their female caretakers, will be used. The research will be conducted in 6 counties that differ in economic development. 40 adolescents from the initial sample who have dropped out of school during the duration of the study will be recruited. The outcomes of the project will be used to advance the social and family policy measures aimed at reducing the negative effects of family economic hardship on family relations and adolescent adjustment problems.]]></summary_en></project><project>
<id>3351</id><title_hr><![CDATA[Razumijevanje, praćenje i analiziranje transparentnosti proračuna lokalnih jedinica: Primjer Hrvatske i Slovenije - Indeks otvorenosti lokalnih proračuna]]></title_hr><title_en><![CDATA[Understanding, monitoring and analysing local government budget transparency:  Case study of Croatia and Slovenia - Open local budget index]]></title_en><user_id>13372</user_id><user_firstLast_name>Katarina Ott</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2014-09</proposal_call><code>IP-2014-09-3008</code><acronim><![CDATA[OLBI]]></acronim><duration>01.09.2015 - 31.08.2019</duration><status>Završio</status><financ_value>48.857,38 eur</financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Ekonomija, </scie_field_hr><scie_field_en>Economy, </scie_field_en><institution_hr><![CDATA[Institut za javne financije]]></institution_hr><institution_en><![CDATA[Institute of Public Finance]]></institution_en><team_members_id>2677, 2754, 13295, 21290, 25362, </team_members_id><team_members_names><![CDATA[Mihaela Bronić, Maja Klun, Velibor Mačkić, Branko Stanić, Simona Prijaković, ]]></team_members_names><keywords_hr><![CDATA[Local government, budget transparency, Open local budget index, Croatia, Slovenia]]></keywords_hr><keywords_en><![CDATA[lokalne jedinice, transparetnost proračuna, Indeks otvorenosti lokalnih proračuna, Hrvatska, Slovenija]]></keywords_en><summary_hr><![CDATA[Transparentnost proračuna lokalnih jedinica (TPLJ) od iznimne je važnosti budući da odluke lokalnih vlasti o trošenju javnih sredstava utječu na svakog građanina.  TPLJ označava u kojoj mjeri i koliko jednostavno građani mogu pristupati informacijama o prihodima i rashodima lokalnih proračuna. Transparentnost proračuna prvi je korak prema demokratizaciji proračunskog procesa i uključivanju građana u oblikovanje politika  i raspodjelu sredstava. Netransparentan proračun ne može se valjano analizirati, njegova se provedba ne može u potpunosti pratiti, niti se mogu vrednovati njegovi ishodi. Unatoč važnosti TPLJ-a, rijetka su istraživanja o njenim mjerenjima, uzrocima i posljedicama. Naš cilj je popuniti tu prazninu u literaturi istražujući: TPLJ u Hrvatskoj i Sloveniji, način na koji se ona mijenja tijekom vremena i razloge zbog kojih su neki lokalni proračuni transparentniji od drugih. Također ćemo nastojati odgovoriti na pitanja utječe li TPLJ na proračunske ishode u izbornim godinama, djeluje li na izborne rezultate i utječu li promjene TPLJ-a tijekom vremena na preferencije političara na vlasti i glasača u vezi s proračunskim ishodima. Oslanjajući se na postojeću literaturu i naše prijašnje radove, cilj nam je postaviti temelj za buduće istraživanje TPLJ-a, čiji će rezultat biti Indeks otvorenosti lokalnih proračuna (IOLP). Najprije ćemo uskladiti i prilagoditi već postojeću hrvatsku metodologiju (Ott, Bronić i Petrušić, 2013.; 2014.), kako bi se  mogla kontinuirano i na isti način primjenjivati na godišnjoj razini u Hrvatskoj i Sloveniji. Budući da će ovo  biti prvi put da se empirijski mjeri i prati TPLJ za prilično dugo razdoblje u dvije zemlje i budući da osim našeg rada (Ott, Bronić i Petrušić, 2013, 2014) nismo uspjeli naći niti jedan drugi rad o uzrocima i posljedicama TPLJ, naš kontinuirani projekt  će predstavljati jedinstven doprinos literaturi. Omogućit ćemo i donošenje boljih politika te veće sudjelovanje građana u odlučivanju o lokalnim proračunima. ]]></summary_hr><summary_en><![CDATA[Local government budget transparency (LBT) is of extreme importance as local authorities’ decisions upon spending public money have an impact on each and every citizen. LBT refers to how easily and to what extent citizens can access information on local government revenues and expenditures. Transparent budgets are a first step toward democratizing the budget process and giving citizens a say in policy formulation and resource allocation. A non-transparent budget cannot be properly analysed, its implementation cannot be thoroughly monitored nor can its outcomes be evaluated. Despite the importance of LBT, research into its measures, causes and consequences is thin. Our aim is to fill this literature gap and investigate: LBT in Croatia and Slovenia, how it changes over time and why some local budgets are more transparent than others. We will also try to answer: whether LBT affects budget outcomes in election years; whether it affects election outcomes and whether its changes over time influence incumbents&#39; and voters’ preferences regarding budget outcomes. Building upon the existing literature and our previous works, the aim is to construct the basis for future research into LBT, resulting in an open local budget index (OLBI). We will first harmonize and adapt the already existing Croatian methodology (Ott, Bronić and Petrušić, 2013; 2014) so that it can be further continually, annually applied in the same way in Croatia and Slovenia. Since this will be the first time that LBT will be empirically measured and monitored for a fairly long period of time in two countries, and since except for our own work (Ott, Bronić and Petrušić, 2013; 2014) we could find no other papers dealing with the causes and consequences of LBT, our continuous research will represent a unique contribution to the existing literature. Our results will also enable better policy-making and greater citizens’ participation in local budget deliberations.  ]]></summary_en></project><project>
<id>3352</id><title_hr><![CDATA[Mikrobna ekologija voda kao pokazatelj zdravstvenog stanja okoliša ]]></title_hr><title_en><![CDATA[Aquatic microbial ecology as an indicator of the health status of the environment]]></title_en><user_id>5800</user_id><user_firstLast_name>Damir Kapetanović</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2014-09</proposal_call><code>IP-2014-09-3494</code><acronim><![CDATA[AQUAHEALTH ]]></acronim><duration>25.11.2015 - 24.11.2019</duration><status>Završio</status><financ_value>122.079,50 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Veterinarska medicina, </scie_field_hr><scie_field_en>Veterinary medicine, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>6257, 5426, 5427, 12841, 5702, 5780, 19037, 119, 21141, 25086, 19718, 25088, 23487, </team_members_id><team_members_names><![CDATA[Irena Vardić Smrzlić, Ana Gavrilovic, Jurica Jug-Dujaković, Dražen Knežević, Darija Vukić Lušić, Kristina Pikelj, Jakov Žunić, Lorena Perić, Anamarija Kolda, Semir Loncarevic, Eddy Listeš, Atle  Lillehaug, Brigita Hengl, ]]></team_members_names><keywords_hr><![CDATA[bakterija, rezistencija, mikrobna ekologija, riba, kvaliteta vode, sediment, zdravlje ljudi]]></keywords_hr><keywords_en><![CDATA[bacteria, resistance, microbial ecology, fish, water quality, sediment, human health]]></keywords_en><summary_hr><![CDATA[Većina studija o mikrobnoj ekologiji vodenog okoliša usredotočena je na odvojene dijelove vodenog ekosustava. našim projektom predlažemo opsežnu studiju bakterijske zajednice u vodenom stupcu, sedimentu i ribama kao pokazateljima zdravstvenog stanja vodenog okoliša i njegovih mogućih implikacija na ljudsko zdravlje. Projektom se nastoji istražiti genetsku raznolikost bakterijskih izolata u vodenom okolišu, od površine do dna, odnose između izolata iz okoliša, onih iz zdravih riba i onih iz riba s kliničkim simptomima bolesti. Ovi podaci su neophodni za predviđanje nastanka i putova širenja bakterijskih pokazatelja kvalitete vode, kao i potencijalno patogenih bakterija, kako za ribe, tako i za ljude. Istražit će se profili rezistencije na antimikrobne lijekove, kako bi se utvrdilo potencijalnu vezu između odabranih modelnih bakterija i njihove rezistencije te učinak različitih uzročnika stresa iz okoliša. Cjelokupna strategija radnog plana je primijeniti multidisciplinarni pristup za istraživanje složenog bakterijskog ekosustava u vodenom okolišu (vidi Sliku 1). Unutar trenutnog partnerstva, četiri zadatka su identificirana, za rješavanje specifičnih problema u vezi s mikrobnom ekologijom vodenog okoliša: 1. Plan i obrazloženje uzorkovanja, 2. Ribe kao modelni organizmi, 3. Odabrane modelne bakterije i 4. Utjecaj na zdravlje ljudi. Istraživanje će se provesti korištenjem infrastrukture i stručnosti prisutne u okviru konzorcija. Projekt će okupiti state of the art istraživanja iz trenutno fragmentiranih područja. Ovo će stvoriti osnovu za daljnje djelovanje u prevenciji bolesti i poremećaja zdravlja riba zbog djelovanja uvjetno patogenih bakterija. Poboljšana održivost okoliša će poboljšati ukupnu ekonomsku održivost sektora akvakulture. To će biti od velikog interesa za širu javnost, proizvođače, potrošače riba i ribljih proizvoda, kao i kreatore i izvršitelje zakona.]]></summary_hr><summary_en><![CDATA[The majority of studies in aquatic microbial ecology focus on the separate segments of aquatic ecosystem. Our project proposes comprehensive study of bacterial community within water column, sediment and fish as indicator of the aquatic environmental health status and its potential implications to human health. The project seeks to understand the genetic diversity of bacterial isolates in the aquatic environment, the relationships between environmental isolates, those from the healthy fish and from fish with clinical symptoms. These data are necessary to predict the origin and spreading pathways of bacterial indicators of water quality, as well as potentially pathogenic bacteria, both for fish and humans. Antibiotic resistance profiles will be explored to determine a potential link between selected model bacteria and their resistance, and the effects of different environmental stress factors. The overall strategy of the work plan is to implement a multidisciplinary approach for the examination of the complex bacterial ecosystem in the aquatic environment. Within the partnership, four tasks have been identified, equating to resolving of specific problem connected with aquatic microbial ecology: 1. Sampling network design and rationale, 2. Fish as model organisms, 3. Selected Model Bacteria and 4. Impact on human health. Research will be carried out using the infrastructures and expertise present within the consortium. The project will bring together state of the art research from currently fragmented research fields in the same area. This will create a basis for further actions in the prevention of diseases and disorders in fish caused by potential pathogens. Improved environmental sustainability will enhance the overall economical viability of the aquaculture sectors, concerned with lowering environmental impacts resulting from current practices. This will be of high interest to the general public, fish consumers, policy makers and policy administrators.]]></summary_en></project><project>
<id>3353</id><title_hr><![CDATA[Razvoj održivog procesa prerade antitoksina ]]></title_hr><title_en><![CDATA[Development of sustainable antitoxin downstream processing]]></title_en><user_id>102</user_id><user_firstLast_name>Beata Halassy</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2014-09</proposal_call><code>IP-2014-09-4915</code><acronim><![CDATA[ANTI TOX NEW]]></acronim><duration>15.09.2015 - 14.02.2020</duration><status>Završio</status><financ_value>131.661,03 eur</financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Biotehnologija, </scie_field_hr><scie_field_en>Biotechnology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu]]></institution_hr><institution_en><![CDATA[University of Zagreb]]></institution_en><team_members_id>1144, 12959, 13090, 17755, 25068, </team_members_id><team_members_names><![CDATA[Tihana Kurtović, Maja Lang Balija, Julija Erhardt, Dora Sviben, Sanja Mateljak Lukačević, ]]></team_members_names><keywords_hr><![CDATA[antitoksin, antivenom, proteini plazme, inaktivacija virusa, (Fab&#39;)2 fragmenti]]></keywords_hr><keywords_en><![CDATA[antitoxin, antivenom, downstream processing, virus inactivation, (Fab&#39;)2 fragments]]></keywords_en><summary_hr><![CDATA[Antitoksini su antitijela životinjskog porijekla koja se koriste za liječenje predoziranja lijekovima (digoksin), virusnih infekcija (bjesnoća), neutralizaciju bakterijskih toksina (difterija, tetanus, botulizam), i liječenje posljedica ugriza životinja životinja otrovnica (zmija, paukova, škorpiona). Antitoksini se proizvode imunizacijom životinja, većinom konja i ovaca, odgovarajućim antigenom (uzvodni dio procesa), i pročišćavanjem imunoglobulina iz hiperimune životinjske plazme (nizvodni dio procesa). Održiv proces prerade životinjskih antitoksina ima i dodatnu vrijednost kao platforma za brzu proizvodnju lijekova protiv potpuno novih bolesti (npr. ebola). Cilj istraživanja je dizajnirati i pronaći optimalne uvjete za najučinkovitiji i najkompaktniji proces pročišćavanja antitoksina na bazi postojećih znanstvenih i tehnoloških dosega. Proces ćemo dizajnirati balansirajući između rastućih regulatornih zahtjeva, iskorištenja procesa (što viši) i troškova pročišćavanja (što niži). Cilj je pronaći optimalne uvjete za svaki korak pročišćavanja, istražiti učinkovitost cijelog postupka u redukciji rizika od virusne kontaminacije, i prikupiti podatke na laboratorijskoj razini koji mogu biti baza za proračune prilikom donošenja odluke za uspostavu pogona održive proizvodnje antitoksina. Istraživat ćemo po prvi put primjenjivost istovremenog taloženja i pepsinske razgradnje konjske plazme, što je pokazano za plazmu ovaca, i učinkovitost navedenog koraka u redukciji rizika od virusne kontaminacije, što još nije istraživano. Također, po prvi puta istražit ćemo primjenjivost kromatografije na monolitnim nosačima u postupcima pročišćavanja antitoksina.]]></summary_hr><summary_en><![CDATA[Antitoxin is the general name for the antibodies of animal origin used to treat for example drug overdose (digoxin), bacterial toxins (diphtheria, tetanus and botulism), viral infections (rabies) and envenoming (snake, spider and scorpion). So antitoxins are produced by immunisation of animals, mostly horse and sheep, by appropriate antigen of interest (upstream part of the process), and subsequent purification of induced immunoglobulins from the hyperimmunised animal plasma (downstream part of the process). Established cost-effective antitoxin production has an additional value serving as a platform that can be easily adapted for fast production of therapeutics to combat new emerging diseases (ebola, for example).The aim of the here proposed research is to design and optimise at the laboratory scale the most effective and most compact purification process (downstream part) based on the current scientific and technological knowledge. The process will be designed by balancing between criteria for fulfilling the growing regulatory demands, purification process yields (as high as possible) and the production costs (as low as possible). The aim is to find the optimal parameters of each purification step, to investigate the effectiveness of the designed process in reducing the risk of viral contamination, and to generate data on laboratory scale that could serve as the basis for decision making process regarding the sustainable antitoxin production plant establishment. The project will investigate for the first time the applicability of single-step simultaneous caprylic acid precipitation and peptic digestion of horse plasma, demonstrated so far only in ovine IgG purification, and the capability of this step in reducing the risk of viral contamination, that has not been investigated yet. Further on, the applicability of monolithic chromatographic supports (convective interaction media) in the process of antitoxin purification will be explored for the first time.]]></summary_en></project><project>
<id>3359</id><title_hr><![CDATA[Fleksigurnost i novi oblici rada (izazovi modernizacije hrvatskog radnog prava)]]></title_hr><title_en><![CDATA[Flexicurity and New Forms of Employment (Challenges regarding Modernization of Croatian Labour Law) ]]></title_en><user_id>5784</user_id><user_firstLast_name>Sandra  Laleta</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2014-09</proposal_call><code>UIP-2014-09-9377</code><acronim><![CDATA[FLEKSINORA]]></acronim><duration>01.07.2015 - 30.06.2018</duration><status>Završio</status><financ_value>38.292,22 eur</financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Pravo, </scie_field_hr><scie_field_en>Law, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Pravni fakultet]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Law]]></institution_en><team_members_id>413, 5585, 5762, 13639, 13680, 13558, 13698, 13714, 13601, 5231, 13716, 13757, 13702, </team_members_id><team_members_names><![CDATA[Vanja Smokvina, Ana Pošćić, Adrijana Martinović, Ivana  Vukorepa, Hießl Christina, anna zilli, marina  brollo, ANDRIJANA BILIĆ, Laura Calafa, Nada Bodiroga-Vukobrat, Darja Senčur Peček, Gerald G. Sander, Ivana Grgurev, ]]></team_members_names><keywords_hr><![CDATA[radno pravo, Hrvatska, fleksigurnost, oblici rada, reforma, ]]></keywords_hr><keywords_en><![CDATA[labour law, Croatia, flexicurity, forms of employment, reform]]></keywords_en><summary_hr><![CDATA[Očekivani rezultati Projekta jesu prijedlozi de lege ferenda (modeli) koji će biti razvijeni i testirani za vrijeme trajanja Projekta. Rezultati će se javno objaviti i diseminirati kroz izvješća i objavljivanjem u inozemnoj i domaćoj literaturi (dostupni sažetak spoznaja do kojih se došlo tijekom istraživanja bit će dostupan kreatorima politika, te znanstvenoj, stručnoj i široj javnosti),  te na konferencijama i kroz znanstvene članke. Rezultati Projekta temeljit će se na sljedećim ciljevima: utvrđivanje inicijative u predmetnom području, utvrđivanje prednosti i nedostataka važećeg regulatornog okvira te utvrđivanje postojećeg stanja,  kao polazišta za sljedeću fazu istraživanja; prijedlog / razvijanje novog regulatornog okvira (modela) u Hrvatskoj i razmjena iskustva i dobrih praksi.]]></summary_hr><summary_en><![CDATA[The outcomes / expected results of this Project will be new de lege ferenda models developed and tested during the course of the Project intended to be implemented in Croatia. The outcomes / results will be made publicly visible and disseminated in a report and in written materials in international and domestic literature (an accessible summary of the findings aimed at policy makers and at scientific, professional and wide public), along with conference presentation and papers. The Project’s outcomes / results will be based upon the following Project objectives: Mapping of initiatives in the area of research interest; determining the pros and cons of the actual regulatory framework in line to highlight the state of facts, and to form the base for the next research stages; proposing / developing of new regulatory framework (models) in Croatia and exchange of experience and best practices.]]></summary_en></project><project>
<id>3362</id><title_hr><![CDATA[Algoritmi za mjerenje sustavskog rizika]]></title_hr><title_en><![CDATA[Algorithms for Systemic Risk Measurement]]></title_en><user_id>13406</user_id><user_firstLast_name>Zvonko Kostanjčar</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2014-09</proposal_call><code>UIP-2014-09-5349</code><acronim><![CDATA[ASYRMEA]]></acronim><duration>01.10.2015 - 30.09.2018</duration><status>Završio</status><financ_value>65.565,07 eur</financ_value><scie_area_hr>Tehničke znanosti, Prirodne znanosti, Društvene znanosti, </scie_area_hr><scie_area_en>Technological sciences, Natural sciences, Social sciences, </scie_area_en><scie_field_hr>Elektrotehnika, Matematika, Fizika, Računarstvo, Ekonomija, </scie_field_hr><scie_field_en>Electrical engineering, Mathematics, Physics, Computer sciences, Economy, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id>13519, 7322, 6508, 5624, 21046, 23106, </team_members_id><team_members_names><![CDATA[Kristian Hengster Movric, Branko Jeren, Dražen Jurišić, Boris Podobnik, Stjepan Begušić, Mate Puljiz, ]]></team_members_names><keywords_hr><![CDATA[sustavski rizik, kompleksni sustavi, mrežna dinamika, rijetkost, vremenski diskretni signali]]></keywords_hr><keywords_en><![CDATA[systemic risk, complex systems, network dynamics, sparsity, discrete time signals]]></keywords_en><summary_hr><![CDATA[Razmatramo kompleksni sustav, poput nuklearne elektrane, koji je građen od velikog broja podsustava s određenom vjerojatnošću kvara koje nisu nezavisne. Zanima nas vjerojatnost kvara cijelog sustava koji se događa kad neki podskup podsustava zakaže, tj. zanima nas sustavski rizik. Kako možemo modelirati takvu situaciju i procijeniti sustavski rizik? Na žalost, to je vrlo teško i nismo dobri u tome, pa tako npr. red veličine vjerojatnosti kvara neke nuklearne elektrane još uvijek nije poznata. Čini se da je to zato što je većina poznatih korelacijskih struktura u vjerojatnosti nisko dimenzionalna ili čak jednodimenzionalna. Međutim, u kompleksnim sustavima su korelacijske strukture visoko dimenzionalne i obično ne vrijedi pretpostavka nezavisnosti. Cilj ovog istraživačkog projekta je pronaći učinkovite algoritme za mjerenje sustavskog rizika definiranjem novih klasa modela višedimenzionalnih korelacijskih struktura u velikom skupu slučajnih varijabli. Definirani modeli moraju biti računalno izvedivi i dovoljno jednostavni da im se parametri mogu estimirati iz podataka u različitim primjenama višedimenzionalne analize podataka.U ovom projektu ćemo nastaviti koristiti metode matematičkog i računalnog modeliranja, konkretno: kompleksnih mreža, rijetkih estimacija i koncentracije mjere. Koristeći ovaj pristup smo već postigli vrlo važne rezultate, poput uvida u nastajanje zakona potencija i dvofaznog ponašanja u fluktuacijama financijskih tržišta. Također bismo s ovim pristupom željeli bolje razumjeti sustavski rizik i stabilnost kompleksnih sustava (npr. financijskog sustava). Potreba za znanstveno utemeljenom mjerom sustavskog rizika nije samo akademska zato što se diljem svijeta pokušava smanjiti rizik i troškovi sustavskih kriza.]]></summary_hr><summary_en><![CDATA[Consider a complex system (such as a nuclear plant) that is made from many subsystems which themselves have certain probabilities of failure, and these probabilities are not independent. Suppose that we are interested in the probability of failure of the entire system, failure that occurs when certain subset of the subsystems fail, i.e. we are interested in the systemic risk. How do we model such a situation and estimate the systemic risk? Unfortunately, this is very difficult, and we are not very good at it, e.g. the order of magnitude of the probability of failure of a nuclear plant is still ungraspable. It seems that this is because most of the familiar correlation structures in probability are low-dimensional, or even one-dimensional. However, correlation structures in complex systems are high-dimensional and usual independence assumption is seriously violated. The goal of this research project is to find efficient algorithms for systemic risk measurement by defining a new class of models of high-dimensional correlation structures in a large collection of random variables. The defined models should be computationally tractable and simple enough so that one can bring them to data and use it for various applications in high-dimensional data analysis.In this project we will continue to use the methods of mathematical and computational modeling, specifically: complex networks, sparse estimation, and concentration of measure. With this approach, we have already obtained very important results, like an insight into the emergence of power-law and two-phase behavior in the financial market fluctuations. Also, with this approach we would like to better understand the basic mechanisms that underlie systemic risk and the stability of the complex systems (e.g. financial system). The need for scientific foundations for a systemic risk measure is more than an academic concern as different people around the world consider how to reduce the risks and costs of systemic crises.]]></summary_en></project><project>
<id>3363</id><title_hr><![CDATA[Sinteza, strukturna analiza i biološka evaluacija peptidomimetika i glikokonjugata ]]></title_hr><title_en><![CDATA[Synthesis, Structural Analysis and Biological Evaluation of Peptidomimetics and Glycoconjugates]]></title_en><user_id>569</user_id><user_firstLast_name>Srđanka Tomić-Pisarović</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2014-09</proposal_call><code>IP-2014-09-7899</code><acronim><![CDATA[PEPTGLYCOSAR]]></acronim><duration>01.06.2015 - 31.05.2019</duration><status>Završio</status><financ_value>97.285,82 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, </scie_field_hr><scie_field_en>Chemistry, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>300, 484, 485, 1146, 492, 3573, 5587, 5597, 5505, 3493, 23983, </team_members_id><team_members_names><![CDATA[Lidija Barišić, Rosana Ribić, Željka Car, Teuta Opačak-Bernardi, Vesna Petrović Peroković, Krešimir Baumann, Mojca Čakić Semenčić, Monika Kovačević, Veronika Kovač, Đani Škalamera, Marija Paurević, ]]></team_members_names><keywords_hr><![CDATA[peptidomimetici, peptidoglikan, feroceni, manokonjugati, bioaktivnost]]></keywords_hr><keywords_en><![CDATA[peptidomimetics, peptidoglycan, ferrocenes, mannoconjugates, bioactivity]]></keywords_en><summary_hr><![CDATA[Osnovni cilj ovog projektnog prijedloga je sinteza, strukturna analiza i biološka evaluacija dvije vrste novih peptidomimetika: (i) peptidnih spojeva peptidoglikanskog tipa s imunomodulacijskim djelovanjem, u svrhu ispitivanja njihove interakcije sa specifičnim receptorima te (ii) peptidnih konjugata s ferocenom, s kiralno organiziranim strukturama ostvarenima povezivanjem intramolekulskim vodikovim vezama, a koje su preduvjet za stvaranje 3D struktura i funkcioniranje bioloških sustava. Također će se pripraviti glikokonjugati tih spojeva te će se proučavati njihova biološka svojstva. Naglasak će biti na manokonjugatima obzirom da je to jedan od monosaharida kojeg prepoznaju specifični receptori na površini stanica. Manozilirani peptidoglikanski fragmenti s adamantanskom podstrukturom ugrađivati će se u liposome na način da manozne jedinice budu na njihovoj površini kako bi bile dostupne za manozne receptore na stanicama imunološkog sustava. Sljedeći je cilj ovog projektnog prijedloga sinteza peptidoglikanskih fragmenata s ugrađenom ferocenskom podjedinicom te pručavanje konformacija tih molekula. Ferocenski alfa-manozidi ispitat će se pomoću testa inhibicije hemaglutinacije kao potencijalni inhibitori infekcije koju uzrokuje Escerichia coli. Ova istraživanja proširit će se i na alfa-manozide heterocikličkih spojeva kao što su 3-hidroksipiridin-4-oni, imidazolijevi i benzimidazolijevi derivati, koji su česti sastavni dijelovi spojeva sa širokim spektrom bioloških djelovanja. Biološka evaluacija svih pripravljenih spojeva ovog projektnog prijedloga provoditi će se, jednim svojim dijelom, u suradničkim institucijama u svrhu korelacije struktura derivata s njihovom biološkom aktivnošću. Studije molekulskog modeliranja koristit će se za predviđanje strukturnih promjena u svrhu poboljšanja aktivnosti.]]></summary_hr><summary_en><![CDATA[In this project proposal the main goal is the synthesis, structural characterization and biological evaluation of novel peptidomimetics of two types: (i) peptidoglycan derived peptides possessing immunomodulating activity in order to study their interactions with specific receptors and (ii) ferrocene-peptide conjugates which comprise an efficient bioorganometallic constraint designed to induce chirally organized structures through intramolecular hydrogen bonding as a prerequisite for 3D structure formation and function of biological systems. Glycoconjugates of these compounds will be prepared and their biological properties studied with emphasis on mannoconjugates since mannose is one of the carbohydrates recognized by receptors on cell surfaces. Mannosylated peptidoglycan fragments with the adamantane moiety will be incorporated into liposomes with mannose exposed at the surface serving in targeting mannose receptors on immune cells. Furthermore, peptidoglycan fragments will be modified with the ferrocenyl moiety and their conformational properties studied. Alpha-mannoside derivatives of these compounds will be also investigated as possible inhibitors of infections caused by Escerichia coli using the hemagglutination test. These studies will be extended to alpha-mannoside derivatives of heterocyclic compounds such as 3-hydroxypyridine-4-ones, imidazoles and benzimidazoles which are common parts of substances with a broad spectrum of biological activities. Screening and evaluation of biological properties of all compounds to be synthesized will be performed, partly in collaborative institutions. Molecular modelling will be used in predicting structural changes leading to improved biological activities. ]]></summary_en></project><project>
<id>3367</id><title_hr><![CDATA[Programski sustav za paralelnu analizu više heterogenih nizova vremenskih podataka s primjenom u biomedicini]]></title_hr><title_en><![CDATA[A software system for parallel analysis of multiple heterogeneous time series with application in biomedicine]]></title_en><user_id>12928</user_id><user_firstLast_name>Alan Jović</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2014-09</proposal_call><code>UIP-2014-09-6889</code><acronim><![CDATA[MULTISAB]]></acronim><duration>01.10.2015 - 30.09.2018</duration><status>Završio</status><financ_value>53.799,19 eur</financ_value><scie_area_hr>Tehničke znanosti, Biomedicina i zdravstvo, </scie_area_hr><scie_area_en>Technological sciences, Biomedicine and health sciences, </scie_area_en><scie_field_hr>Računarstvo, Kliničke medicinske znanosti, Javno zdravstvo i zdravstvena zaštita, </scie_field_hr><scie_field_en>Computer sciences, Clinical sciences, Public health and health services, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id>12932, 12925, 12920, 12750, 18915, </team_members_id><team_members_names><![CDATA[Krešimir Jozić, Car Siniša, Marko Horvat, Marko Velić, Mario Cifrek, ]]></team_members_names><keywords_hr><![CDATA[vremenski nizovi, obrada biomedicinskih signala, nelinearna dinamika, ekspertni sustav, klasifikacijski model, umjetna inteligencija]]></keywords_hr><keywords_en><![CDATA[time series, biomedical signal processing, nonlinear dynamics, expert system, classification model, artificial intelligence]]></keywords_en><summary_hr><![CDATA[Zadatak analize vremenskih nizova jest otkrivanje i klasifikacija značajnih obrazaca ponašanja u podacima koji sadrže vremensku komponentu. Ovaj projekt bavit će se razvojem cjelovitog programskog sustava koji uključuje opće i domenske značajke vremenskih nizova, i primjenjuje ih u biomedicini. Cilj projekta je razviti učinkovit i nadogradiv sustav za automatsku klasifikaciju poremećaja rada ljudskog organizma na temelju analize više heterogenih biomedicinskih signala (srčani ritam, EKG, EEG i dr.). Uz izradu klasifikacijskih modela, predviđa se razvoj vizualizacije poremećaja uporabom računalne grafike. Radi povećanja brzine, koristit će se paralelna obrada u višejezgrenom režimu rada. Sustav će objedinjavati podsustavi za: 1) odabir, prikaz i prilagođavanje zapisa jednog ili više ulaznih signala, 2) paralelnu obradu i izlučivanje više domenskih i općih značajki signala, 3) vizualizaciju signala i poremećaja korištenjem računalne grafike i 4) automatsku izgradnju i završno vrednovanje modela. Za vrednovanje će se koristiti referentne internetske baze zapisa biomedicinskih signala s portala PhysioNet te, po mogućnosti, anonimizirani zapisi iz lokalnih bolnica. Jedan od doprinosa sustava bit će ekspertni podsustav za automatsko predlaganje skupa značajki koje se trebaju izlučivati. Opće značajke signala koje će se implementirati uključivat će relevantne značajke nelinearne dinamike za karakterizaciju jednog ili više signala. Specijalizirane, domenske značajke implementirat će se za svaku vrstu biomedicinskog signala zasebno. Pri izgradnji modela poremećaja, provest će se smanjenje dimenzionalnosti prostora značajki. Model poremećaja gradit će se na temelju algoritama jasnog opisa kao što su klasifikacijska pravila i na temelju algoritama za postizanje najveće točnosti kao što su ansambli stabala odluke. U okviru ovog interdisciplinarnog projekta, očekuje se više doprinosa u područjima računarske znanosti, biomedicinskog inženjerstva i medicine.]]></summary_hr><summary_en><![CDATA[The task of time series analysis is to discover and classify significant patterns in data that contain a temporal component. This project deals with development of an integrated software system that includes general and domain specific time series features, with application in biomedicine. The goal of the project is to develop an efficient and upgradeable system for automatic classification of human body disorders based on the analysis of multiple heterogeneous biomedical signals (heart rhythm, ECG, EEG, etc.). In addition to classification, the project will also pursue visualization of disorders using computer graphics. Calculation speed will be increased using multicore parallelization. The system will contain subsystems for: 1) selection, display, and pre-processing of multiple signals from input records, 2) parallel analysis and extraction of multiple domain specific and general signal features, 3) visualization of signals and disorders using computer graphics, and 4) automatic construction and evaluation of the models. For evaluation purposes, the project will use referential biomedical signal databases from the PhysioNet portal and, if possible, anonymous records from local hospitals. One of the contributions of the system will be development of an expert subsystem for automatic recommendation of the set of features that should be extracted. The implemented general signal features will include relevant nonlinear dynamics measures. Specialized, domain specific features will be implemented for each type of biomedical signal individually. When constructing disorder models, feature space dimensionality reduction will be pursued. Disorders will be modeled based on clear description machine learning algorithms such as classification rules as well as maximum accuracy algorithms such as decision tree ensembles. Within the scope of this interdisciplinary project, several contributions in the areas of computer science, biomedical engineering, and medicine are expected.]]></summary_en></project><project>
<id>3368</id><title_hr><![CDATA[Jezik izdanja hrvatske protestantske tiskare u kontekstu književnojezičnih smjernica XVI. st.]]></title_hr><title_en><![CDATA[The language of the Urach protestant press editions within context of the 16th century literary language guidelines]]></title_en><user_id>11240</user_id><user_firstLast_name>Mateo Zagar</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2014-09</proposal_call><code>IP-2014-09-6415</code><acronim><![CDATA[JezHrvProt]]></acronim><duration>01.10.2015 - 30.09.2019</duration><status>Završio</status><financ_value>20.277,39 eur</financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Filologija, </scie_field_hr><scie_field_en>Philology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Filozofski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Humanities and Social Sciences]]></institution_en><team_members_id>2586, 1236, 13568, 24332, </team_members_id><team_members_names><![CDATA[Ivana Eterović, Tanja Kuštović, Stjepan Damjanović, Vera Blažević Krezić, ]]></team_members_names><keywords_hr><![CDATA[povijest hrvatskog jezika, glagoljica, ćirilica, latinica, hrvatska protestantska književnost]]></keywords_hr><keywords_en><![CDATA[history of croatian language, glagolitic alphabet, cyrillic alphabet, latin alphabet, literature of croatian protestants]]></keywords_en><summary_hr><![CDATA[Ovaj je projekt osmišljen kao temeljit opis jezičnog stanja u hrvatskim izdanjima protestantske tiskare iz Uracha (glagoljicom, ćirilicom i latinicom, 1555, 1561-1565, 1568). Važnost temeljite obrade ovoga korpusa počiva na dinamičnosti prijelomnih zbivanja u koncipiranju jezika hrvatske knjige u XVI. st, iznimno važnom razdoblju kada se, na temelju urušenog srednjovjekovnog ustroja „trostruko artikuliranog“ književnog jezika (ovisno o tekstnim funkcijama) i uspostavljene diglosije (Ferguson 1959, Corin 1993), a prije razrade čvrste jezične politike u posttridentskoj ranonovovjekovnoj Europi kojom će početi tzv. protostandardizacijsko razdoblje hrvatskoga jezika, u tiskanoj glagoljskoj knjizi nastoji promovirati jedinstven jezik. Premda je dosad bilo vrlo vrijednih pokušaja opisa jezika ovoga korpusa taj je posao obavljen ili starijom metodologijom (F. Fancev, 1916), ili tek na manjem dijelu korpusa (Damjanović 2010, 2011; Čupković 2010, 2013). Posljednjih desetak godina stvorene su dobre pretpostavke da se novom metodologijom potpuno opiše ova dionica jezične povijesti: objavljeni su mnogi pretisci, od kojih najveće djelo Novi testament (1562, 1563) i u latiničkoj transliteraciji (2013); provedena je temeljita komparativna analiza Misala hruackoga Š. Kožičića Benje (1531) i prethodnih triju tiskanih hrvatskoglagoljskih misala. Cilj je ovog projekta objaviti transliteracije i nekih drugih uraških glagoljičkih izdanja (prije svega Katekizma, Postile, Artikula), i to usporedbeno sa stanjem u paralelnim ćiriličkim i latiničkim izdanjima, te provesti analizu na svim jezičnim razinama, osobito na sintaktičkoj i leksičkoj. Novu metodologiju odlikuje odustajanje od dominacije dijakronijske perspektive, te usmjeravanje na sinkrono koncipiranje jezika unutar kojega se kombiniraju jezični elementi iz sva tri hrvatska narječja te elementi crkvenoslavenskoga jezika.]]></summary_hr><summary_en><![CDATA[      The project has been devised to describe in detail the language condition of Croatian editions printed at the Protestant press in Urach (in Glagolitic, Cyrillic and Latin, 1555, 1561-1565, 1568). The significance of the thorough analysis of corpus in question lies in the dynamics of the crucial moments that determined the outline of the16th century Croatian literary language. That particular period, between the collapsed medieval system of ‘triple articulation’ literary language (depending on the text functions) and the established diglossia (Ferguson 1959, Corin 1993), but before the development of the firm language policy in Post-Tridentine Early Modern Age Europe which signified the beginning of the so-called proto-standardisation era of the Croatian language, is very important in the attempt to promote the uniform language of printed Glagolitic texts.The previous noteworthy attempts to describe the corpus language (17 editions in three scripts, c. 2000 folios in Glagolitic only) were executed using either the obsolete methodology (F. Fancev, 1916) or the smaller sample (Damjanović 2010, 2011; Čupković 2010, 2013). In the past ten years, the new methodology has provided a strong groundwork for full description of that division of language history; reprints were published, the most important of which is The New Testament (1562, 1563) in Latin transliteration (2013); a comprehensive comparative analysis of Kožičić’s Misal hruacki (1531) and the three previously printed Croato-Glagolitic missals were conducted. The project’s objective is the publishing of transliterations and other selected Glagolitic editions from Urach  in comparison with parallel Cyrillic and Latin editions, as well as conducting analysis at all language levels. The new methodology abandons the diachronic perspective domination and is directed towards a synchronic approach in combining the language elements of all three Croatian dialects as well as those of the Church Slavonic language.]]></summary_en></project><project>
<id>3372</id><title_hr><![CDATA[Utjecaj akvakulture na prirodne morske populacije]]></title_hr><title_en><![CDATA[Aquaculture impact on wild marine populations]]></title_en><user_id>3217</user_id><user_firstLast_name>Tanja Šegvić Bubić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2014-09</proposal_call><code>IP-2014-09-9050</code><acronim><![CDATA[AquaPop]]></acronim><duration>01.09.2015 - 31.10.2019</duration><status>Završio</status><financ_value>106.536,60 eur</financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Biotehnologija, </scie_field_hr><scie_field_en>Biotechnology, </scie_field_en><institution_hr><![CDATA[Institut za oceanografiju i ribarstvo]]></institution_hr><institution_en><![CDATA[Institute of Oceanography and Fisheries]]></institution_en><team_members_id>4254, 3600, 6619, 3959, 178, 2850, 18930, 18929, 21299, </team_members_id><team_members_names><![CDATA[Ivan  Katavić, Leon Grubišić, Vjekoslav Tičina, Nika Stagličić, Jasna  Maršić-Lučić, Ivana Radonić, Luka Čulić, Iva  Žužul, Igor Talijančić, ]]></team_members_names><keywords_hr><![CDATA[Akvakultura, utjecaj, prirodne populacije riba i školjkaša, ekološke zamke, prebjezi, genetske interakcije]]></keywords_hr><keywords_en><![CDATA[Aquaculture, Impact, Wild fish and shellfish populations, ecological traps, escapees, genetic interactions]]></keywords_en><summary_hr><![CDATA[Zbog stalnog rasta broja lokacija za uzgoj morskih organizama javlja se sveprisutna zabrinutost da marikultura kao gospodarska djelatnost može predstavljati opasnost za morsku biološku raznolikost kroz negativni utjecaj na prirodne populacije morskih organizama kao i cjelokupni morski ekosustav. Ekološke interakcije se odražavaju kroz činjenicu da kavezne uzgojne instalacije postaju nove ekološke niše za prirodne populacije ribe kod kojih promjene u fiziologiji i ponašanju su moguće. Drugi rizik za okoliš se očituje u mogućem utjecaju zbjegova uzgojne ribe iz kaveza prisutne u morskom okolišu kao rezultat slučajnog bijega iz kaveza ili namjernog poribljavanja. Pobjezi ili poribljavane jedinke iz uzgoja predstavljaju potencijalni rizik genetskoj osnovi izvornih ribljih populacija. Zbog boljeg razumijevanja složenosti  utjecaja akvakulture na prirodne populacije, ovaj projekt će iskoristiti najnovije instrumentalne i genetske pristupe s ciljem podržavanja uzgojnih i upravljačkih aktivnosti, kao i zaštite morskog okoliša. Projekt uključuje: (i) uporabu suvremenog sustava stereoskopske kamere i multivarijatnih analizi indirektnih pokazatelja kondicije s ciljem procjene uloge uzgajališta kao ekoloških zamki divljih ribljih populacija, (ii) korištenje forenzički svojstvenih genetskih alata u procjeni genetske strukture divljih/uzgojnih riba i školjkaša , (iii) uporaba suvremenog genetski-analitičkog pristupa s ciljem određivanja porijekla uzgojnih populacija i utvrđivanja možebitnih genetskih interakcija populacija iz uzgoja s prirodnim/divljim populacijama iste vrste, a na kraju (iv) procjena utjecaja translokacije mlađi kamenica između geografski udaljenih uzgojnih lokacija na genetsku strukturu izvornih populacija kamenice u hrvatskom dijelu Jadrana.Zaključno, predloženi projekt se nadovezuje na zajednički izazov evropske zajednice  koji se očituje u poticanju razvoja održive akvakulture kroz poboljšanje konkurentnosti i ekološki prihvatljive proizvodnje. Kako su potencijalno negativni učinci akvakulture prisutni u svim zemljama EU-a, međunarodna suradnja će se biti prepoznata i implementirana tijekom provedbe projektnih zadataka. Projektni ishodi će biti dostupni svim zainteresiranim strankama odnosno istraživačima, industriji, zakonodavnim tijelima i svim potencijalnim korisnicima.]]></summary_hr><summary_en><![CDATA[Expansion of marine farming sites raised the concern that aquaculture may pose a threat to biodiversity due to detrimental impacts on wild populations and ecosystem. Ecological interactions of farm installations are reflected through  acting as new ecological niches for the local fish where also altered wild fish physiology and behaviour may occur. Another environmental risk is the potential impact of releasing farmed fish into the wild, through accidental escape or deliberate restocking. Escapes or releases of the domesticated aquaculture fish pose a potential risk of adverse effects on native fish gene pools. To better understand the complexity of aquaculture impacts on the native populations, this project will take advantage of cutting edge instrumental and genetic approaches to support aquaculture activity and management, as well as the protection of marine environment. This includes: (i) using novel stereoscopic camera system and multivariable analysis of proxy measure of fitness to asses do farms function as ecological traps for wild fish, (ii) using forensically validated genetic tools to assess genetic structure of wild/farmed fish and shellfish, (iii) using cutting edge genetic analytical approach to trace the origin of farmed fish and to monitor genetic interactions between fish from aquaculture and their wild conspecifics, and finally (iv) validation of the impact of oyster spat translocation between geographically distinct farming locations on genetic structure of native oysters populations in the Croatian part of the Adriatic Sea. Thus, this project addresses the common European challenge to develop sustainable aquaculture through improved competitiveness and environmentally-friendly production. As the potential adverse effects of aquaculture affect all EU countries, international collaboration will be implemented. The outcome of the project will be available to the researchers, the industry, policy makers and the general public.]]></summary_en></project><project>
<id>3389</id><title_hr><![CDATA[Recommender System for Service-oriented Architecture ]]></title_hr><title_en><![CDATA[Sustav predlaganja u arhitekturi zasnovanoj na uslugama]]></title_en><user_id>7793</user_id><user_firstLast_name>Siniša Srbljić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2014-09</proposal_call><code>IP-2014-09-9606</code><acronim><![CDATA[RSOA]]></acronim><duration>01.09.2015 - 31.08.2018</duration><status>Završio</status><financ_value>84.478,07 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Računarstvo, </scie_field_hr><scie_field_en>Computer sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id>11194, 12997, 12993, 12998, 22589, 13653, </team_members_id><team_members_names><![CDATA[Goran Delač, Marin Šilić, Klemo Vladimir, Zvonimir Pavlić, Adrian Satja Kurdija, Miroslav Popović, ]]></team_members_names><keywords_hr><![CDATA[sustav preporuke, arhitektura zansnovana na uslugama, kompozicije usluga, pomoć pri programskom oblikovanju, funkcijska i nefunkcijska svojstva]]></keywords_hr><keywords_en><![CDATA[recommender system, service-oriented architecture, service compositions, development assistance, functional and non-functional properties]]></keywords_en><summary_hr><![CDATA[Razvojem platformi vezanih uz računalne oblake (engl. Cloud computing) i internet stvari (engl. Internet of Things), sustavi utemeljeni na arhitekturi zasnovanoj na uslugama (engl. service-oriented architecture - SOA) dobivaju sve više na značaju. SOA je arhitekturalni stil koji pruža smjernice razvoja slabo povezanih raspodijeljenih sustava. Središnji objekt SOA-e su usluge, samostalni primjenski programi, kojima se pristupa korištenjem standardiziranih sučelja. Jedna od glavnih prednosti SOA-e jest mogućnost povezivanja više usluga u kompozitne sustave (kompozicije usluga). Unatoč jasnim prednostima, uz razvoj kompozicija usluga veže se niz poteškoća vezanih uz ostvarivanje funkcijskih i nefunkcijskih svojstava građenog sustava. Trenutni istraživački rezultati ne pružaju odgovor kako učinkovito graditi kompozicije usluga u slučaju kad su dostupni vrlo veliki imenici usluga te kad je složenost tijeka izvođenje građene kompozicije vrlo velika. 	Cilj ovog istraživačkog projekta je izraditi cjelovit sustav preporuke čija je uloga pojednostaviti izgradnju kompozicija usluga pružanjem pomoći programskim inženjerima u ostvarivanju funkcijskih i nefunkcijskih ciljeva. Naši prijašnji istraživački rezultati pokazuju da je izgradnja takvog sustava moguća. Kroz ovaj projekt cilj nam je proširiti postojeće rezultate s novim metodama preporuke posebno prilagođenim sustavima zasnovanima na arhitekturalnom stilu SOA.	U području funkcijskih ciljeva, predloženi sustav preporuke će omogućiti automatsku preporuku usluga zasnovanu na morfološkoj strukturi građene kompozicije usluga. Osim toga, sustav će primjenom tehnologija dijeljenja znanja omogućiti korisnicima da pronađu odgovarajuću ljudsku pomoć. U području nefunkcijskih svojstava, primijenit će se skup statističkih metoda za procjenu pouzdanosti atomarnih (gradivih) usluga. Zaključno, sustav će omogućiti učinkovito unapređivanje nefunkcijskih svojstva izgrađene kompozicije s obzirom na složenost tijeka izvođenja.]]></summary_hr><summary_en><![CDATA[In recent years, systems based on service-oriented architecture (SOA) have been gaining a lot of traction due to proliferation of cloud computing and Internet of Things (IoT) platforms. SOA is an architectural style that provides guidelines for development of loosely coupled distributed systems. The concept relies on services, self-contained applications which can be consumed using well-established interfaces. One of the most pronounced benefits of SOA is the ability to combine multiple services into a component-based application (service composition). Despite having clear advantages, service composition development entails issues when it comes to reaching both the required functional and non-functional application goals. Specifically the current research results do not offer an answer how to build service compositions efficiently when faced with large service repositories and very complex service workflows.	The goal of this project is to put forward a comprehensive recommender system aimed at simplifying development of service compositions by assisting developers in reaching both functional and non-functional application goals. Our previous research efforts, demonstrate that designing such a recommender is feasible. As part of this project we want to extend the preliminary research with novel recommender methods suited for SOA-based systems. Regarding functional properties, the proposed recommender is to facilitate automatic service recommendations based on the morphological structure of the constructed application. Furthermore, the recommender is to utilize knowledge sharing technologies to assist in enlisting most adequate human help. In the domain of non-functional properties, a set of methods used to determine reliability of atomic services based on statistical approaches will be applied. Finally, a method for efficient improvement of service composition’s non-functional properties will be utilized.]]></summary_en></project><project>
<id>3391</id><title_hr><![CDATA[Nove biopolimerne mikrokapsule za kontrolirano otpuštanje tvari za zaštitu/ishranu bilja ]]></title_hr><title_en><![CDATA[New biopolymer based microcapsules for plant protection/nutrition agents controlled release]]></title_en><user_id>736</user_id><user_firstLast_name>Marko Vinceković</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2014-09</proposal_call><code>UIP-2014-09-6462</code><acronim><![CDATA[NewBioCap/NoveBioKap]]></acronim><duration>01.09.2015 - 31.08.2018</duration><status>Završio</status><financ_value>44.196,70 eur</financ_value><scie_area_hr>Biotehničke znanosti, Prirodne znanosti, </scie_area_hr><scie_area_en>Biotechnical sciences, Natural sciences, </scie_area_en><scie_field_hr>Poljoprivreda, Kemija, </scie_field_hr><scie_field_en>Agriculture, Chemistry, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Agronomski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Agriculture]]></institution_en><team_members_id>4407, 7227, 3287, 3131, 5708, 13477, </team_members_id><team_members_names><![CDATA[Edyta Đermić, Marija Bujan, Nenad Jalšenjak, Snježana Topolovec-Pintarić, Ivanka Žutić, Sanja Fabek, ]]></team_members_names><keywords_hr><![CDATA[biopolimeri, simultana mikroinkapsulacija biočimbenika, biološki aktivne tvari, kemijski aktivne tvari, ishrana bilja,]]></keywords_hr><keywords_en><![CDATA[biopolymers,  simultaneous microencapsulation of biofactors, biologically active agents, chemically active substances, plant nutrition]]></keywords_en><summary_hr><![CDATA[Mikrokapsule na bazi biopolimera s inkapsuliranim jednim bioaktivnim agensom imaju široku primjenu u poljoprivredi te su postale jedna od standardnih tehnika. Međutim, znanje o simultanoj inkapsulaciji biološkog i kemijskog agensa je prilično ograničeno. Glavni cilj ovog projekta je istražiti simultanu inkapsulaciju sredstava za  zaštitu/ishranu bilja u biopolimerne mikrokapsule. Specifični ciljevi su: (i) istraživanje molekulskih međudjelovanja u sustavima s biopolimerima suprotnih naboja, (ii) istraživanje novih biopolimernih mikrokapsula, t.j. istraživanje međudjelovanja bioaktivnog agensa i sustava za isporuku,  (iii) istraživanje optimalnih uvjeta za simultano inkapsuliranje biološkog i kemijskog agensa, (iv) laboratorijska istraživanja optimalnih formulacija mikrokapsula i (v) in vivo testiranje optimalnih formulacija mikrokapsula na salati i rajčici u konvencionalnom i  hidroponskom uzgoju.Naša će nastojanja biti usmjerena na istraživanje kitozan/alginat mikrokapsula prikladnih za simultano inkapsuliranje bakra ili kalcija s Trichoderma viride. Predložena istraživanja su interdisciplinarna i provest će se na modelnim sustavima s biopolimerima suprotnih naboja. Istraživanja modelnih sustava, kod kojih je u velikoj mjeri smanjen broj varijabli, pomoći će objasniti međudjelovanja suprotno nabijenih biopolimera i bioaktivnih agensa i dati smjernice za izradu novih formulacija mikrokapsula. U istraživanjima će se koristiti velik broj različitih standardnih i modernih tehnika/metoda. Projekt je u biti fundamentalan, ali je od velike praktične važnosti jer će bolje razumijevanje međudjelovanja  biopolimera i bioaktivnih agensa na molekulskoj razini poslužiti kao podloga za pripravu novih formulacija mikrokapsula za primjenu.]]></summary_hr><summary_en><![CDATA[Biopolymer based microcapsules with a single bioactive agent have extensive applications in agriculture and become one of standard formulation techniques nevertheless our knowledge of simultaneous encapsulation of biological and chemical agents is still rather limited.The main aim of this proposal is to investigate simultaneous encapsulation of protection/nutrition agents in biopolymer based microcapsules. The specific goals are: (i) investigations of intermolecular interactions in systems with biopolymers of opposite charges, (ii) investigations of biopolymer based microcapsules, i.e. investigations of interactions between bioactive agents and the delivery system, (iii) investigation of conditions for simultaneous encapsulation of biological and chemical agents, (iv) laboratory investigations of optimal microcapsule formulations, (v) in vivo testing of optimal microcapsule formulations on conventionally and hydroponically grown lettuce and tomato.Our efforts will be focused on the investigation of chitosan/alginate microcapsules suitable for simultaneous encapsulation of copper or calcium with Trichoderma viride. The investigations will be done by an interdisciplinary approach on model systems with oppositely charged species based on mixtures containing two biopolymers. Studies of model systems, where the number of variables is greatly reduced, help to explain the intermolecular interactions between oppositely charged biopolymers and bioactive agents, which constitute a highly useful guideline for preparation of novel microcapsule formulations. Various common and modern techniques/methods will be used in investigation. The project, while being fundamental in nature, is of direct practical importance because better understanding of interactions between oppositely charged biopolymers and bioactive agents at the molecular level will serve as a base for production of novel microcapsule formulations for plant protection/nutrition.]]></summary_en></project><project>
<id>3392</id><title_hr><![CDATA[Cijepljenje rajčice ublažava biotički stres izazvan štitastim moljcima ]]></title_hr><title_en><![CDATA[Tomato grafting mitigates biotic stress caused by whiteflies ]]></title_en><user_id>3557</user_id><user_firstLast_name>Katja Žanić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2014-09</proposal_call><code>IP-2014-09-3365</code><acronim><![CDATA[TomGraf / TomGraf]]></acronim><duration>01.07.2015 - 30.06.2018</duration><status>Završio</status><financ_value>92.308,05 eur</financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Poljoprivreda, </scie_field_hr><scie_field_en>Agriculture, </scie_field_en><institution_hr><![CDATA[Institut za jadranske kulture i melioraciju krša]]></institution_hr><institution_en><![CDATA[Institute for Adriatic Crops and Karst Reclamation in Split]]></institution_en><team_members_id>5091, 4176, 3978, 6003, 3954, 4981, 3466, 4400, 1192, 21281, </team_members_id><team_members_names><![CDATA[Gvozden Dumičić, Branimir Urlić, Slavko Perica, Gabriela Vuletin Selak, Ivica Ljubenkov, Dragan Žnidarčič, Maja Jukić Špika, Elda Vitanović, Ivana  Bočina, Marija Mandušić, ]]></team_members_names><keywords_hr><![CDATA[Solanum lycopersicum,  podloge, Bemisia tabaci, Trialeurodes vaporariorum, zaštita bila]]></keywords_hr><keywords_en><![CDATA[Solanum lycopersicum,  rootstocks, Bemisia tabaci, Trialeurodes vaporariorum, pest management]]></keywords_en><summary_hr><![CDATA[Rajčica je važna kultura diljem svijeta, kao i u Hrvatskoj. Spada među najvažnije kulture koje se uzgajaju u zaštićenom prostoru, često u uskom plodoredu. Stoga različiti abiotički i biotički čimbenici stresa ozbiljno ograničavaju ovaj vid uzgoja. Cijepljenje je metoda kojom se izbjegava ili smanjuje gubitak u proizvodnji povrća uzrokovan nepovoljnim uvjetima uzgoja. Tako je cijepljenje, kao metoda za ublažavanje problema izazvanih štetnicima lista rajčice, štitastim moljcima Bemisia tabaci i Trialeurodes vaporariorum, odabrano za glavni cilj projekta TomGraf. Specifični ciljevi su zadani kako bi se utvrdio učinak cijepljenja/podloge na ublažavanje stresa izazvanog s B. tabaci i T. vaporariorum na presadnicama rajčice (ciklus presadnica ljeto/jesen, 2015.), ublažavanje stresa od B. tabaci u hidroponskom nasadu rajčice (ciklus proljeće/ljeto, 2016.) te na ublažavanje stresa od T. vaporariorum u hidroponskom nasadu rajčice (ciklus proljeće/ljeto, 2017.). Istraživanje će se provesti na sorti rajčice Clarabella (necijepljena, cijepljena na vlastiti korijen te cijepljena na četiri komercijalne podloge: Arnold, Beaufort, Emperador i He-Man). Presadnice i hidroponski nasadi rajčice će se infestirati populacijama štitastih moljaca koje održavamo na IJK. Osim glavnog pokusnog zadatka, ocjene gustoće populacije različitih razvojnih stadija štitastih moljaca, učinak cijepljenja istraživat će se i u odnosu na: vegetativni i reproduktivni rast i razvoj rajčice, fiziološke parametre te kvalitetu ploda. Očekujemo odabir podloge/a koja će se moći koristiti kao dio strategije suzbijanja štitastih moljaca, osiguravajući uz to zadovoljavajući učinak na prinos i kvalitetu ploda rajčice.]]></summary_hr><summary_en><![CDATA[Tomato is a crop of high importance worldwide as well as in Croatia. It is among the most grown crops in protected cultivation that is characterised with narrow crop rotation. Consequently, diverse abiotic and biotic stressors seriously limit this type of cultivation. Grafting is a method to avoid or reduce loss in vegetable production caused by adverse growing conditions. Thus, tomato grafting as method to alleviate problems caused by foliar pests; whiteflies Bemisia tabaci and Trialeurodes vaporariorum, has been selected as the main objective of the TomGraf project. The specific objectives have been defined to determine the grafting/rootstock effect on: mitigation B. tabaci and T. vaporariorum stresses on tomato transplants (summer/autumn transplants cycle in 2015), mitigation B. tabaci stress in hydroponically grown tomato (spring/summer cycle in 2016), and mitigation T. vaporariorum stress in hydroponically grown tomato (spring/summer cycle in 2017). The study will be conducted using tomato cv. Clarabella (non-grafted, self-grafted, or grafted onto the commercial rootstocks Arnold, Beaufort, Emperador and He-Man). Tomato transplants and hydroponically grown tomatoes will be infested by whitefly populations maintained at IAC. Besides the main experimental task, the whitefly population densities assessment at different development stages, the effect of grafting on tomato vegetative and reproductive growth and development, physiological parameters and fruit quality will be studied. We expect that selection of rootstock/s can be used as a useful tool in management strategy against whiteflies ensuring the satisfactory effect on yield and fruit quality components.]]></summary_en></project><project>
<id>3393</id><title_hr><![CDATA[Stanica za zamjenu baterija električnih vozila]]></title_hr><title_en><![CDATA[Electric Vehicle Battery Swapping Station]]></title_en><user_id>7162</user_id><user_firstLast_name>Hrvoje Pandžić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2014-09</proposal_call><code>IP-2014-09-3517</code><acronim><![CDATA[EV BASS]]></acronim><duration>01.10.2015 - 30.09.2018</duration><status>Završio</status><financ_value>99.299,52 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Elektrotehnika, </scie_field_hr><scie_field_en>Electrical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id>7001, 4569, 7194, 7348, 6996, 13621, 13656, 7186, 904, 1506, 20536, 20181, </team_members_id><team_members_names><![CDATA[Tomislav Capuder, Marija Furdek, Matija Zidar, Juraj Havelka, Marko Delimar, Ivan Pavić, Iva Širić, Ninoslav Holjevac, Tomislav Dragičević, Danijela Miloš Sprčić, Davor Zoričić, Vedran Bobanac, ]]></team_members_names><keywords_hr><![CDATA[električna vozila, baterije, stanica za izmjenu baterija, poslovni model, optimizacijski model]]></keywords_hr><keywords_en><![CDATA[electric vehicles, batteries, battery swapping station, business model, optimization model]]></keywords_en><summary_hr><![CDATA[Za masovnu upotrebu električnih vozila potrebno je uspostaviti adekvatnu infrastrukturu. Sveprisutan pristup predmetnoj infrastrukturi smanjuje brigu oko dosega električnih vozila i dugih vremena punjenja baterija. Stanice za izmjenu baterija električnih vozila svakako su učinkovito sredstvo za uklanjanje problema dugotrajnog čekanja na punjenje baterija. Te su stanice posrednici između elektroenergetskog sustava i svojih klijenata. Za uspješnu izgradnju i poslovanje ovih stanica potrebno je prvo izraditi poslovni, a potom i operativni model. Na taj će se način osigurati da stanica za izmjenu baterija električnih vozila bude održiva nudeći brzu i pouzdanu uslugu kao alternativu dugotrajnom punjenju baterija.Prvi dio projekta usmjeren je na analizu trenutne situacije u znanstvenoj i stručnoj literaturi, komercijalnim tvrtkama koje se bave električnim vozilima te zakonskim okvirima. Na temelju predmetne analize razvit će se održivi poslovni model stanice za izmjenu baterija električnih vozila. Znanstveno istraživanje će se potom granati u dva smjera. Prvi smjer odnosi se na optimizaciju pogona stanice za izmjenu baterija, što uključuje kreiranje rasporeda pogona za dan unaprijed te u stvarnom vremenu. Drugi smjer odnosi se na upravljanje i komunikaciju unutar same stanice. Naime, potrebno je konstantno poznavati napunjenost svake baterije u stanici te puniti odgovarajuće baterije prema planu punjenja kreiranom od strane optimizacijskog modela.Drugi dio istraživanja bavit će se utjecajem jedne i više stanica za izmjenu baterija električnih vozila na elektroenergetski sustav. Pritom će se zasebno razmatrati gledišta Operatora Distribucijskog Sustava i Operatora Prijenosnog Sustava.Posljednji dio projekta biti će primijenjene naravi. Osmislit ćemo i instalirati stanicu za izmjenu baterija koja će se sastojati od središnjeg računala koje će upravljati stanicom, velikim brojem stogova baterija i popratne upravljačke i komunikacijske opreme. Ovime ćemo ispitati razvijene algoritme u stvarnom okruženju i potvrditi rezultate simulacija.]]></summary_hr><summary_en><![CDATA[For a successful rollout of EVs, it is required to establish an adequate charging infrastructure. The ubiquitous access to such infrastructure would help to mitigate concerns associated with limited EV range and long charging times. Battery Swapping Stations (BSSs) are poised as effective means of eliminating the EVs long waiting times associated with charging the batteries. These stations are mediators between the power system and their customers. In order to successfully deploy this type of stations, business and operating models are required, that will allow it to generate profits while offering a fast and reliable alternative to charging batteries.The first part of the project is focused on analysis of current scientific and commercial state-of-the-art, as well as legislative. Based on this, a viable business model will be developed as a basis of the BSS business case. The research will then diverge in two directions. The first direction is the optimization of the BSS operation, which includes its day-ahead scheduling and real-time operation. The second direction is the control and communication of the BSS. Namely, each battery’s state-of-charge needs to be properly assessed, and its charging pattern needs to correspond to the one set by the optimization model. The second part of the project will assess the impacts that BSS and a group of BSSs have on power systems. Here, points of view of Distribution and Transmission System Operators will be considered.The final stage of the project will be the deployment of a testbed that consists of a central computer, a large number of EV battery stacks, and all the accompanying control and communications infrastructure. This will provide the opportunity to test the developed algorithms in a realistic environment and to verify the results.]]></summary_en></project><project>
<id>3395</id><title_hr><![CDATA[Istraživanje razvoja, diferencijacije i evolucije životinja kroz genomiku bazalnih metazoa ]]></title_hr><title_en><![CDATA[Elucidating animal development, differentiation and evolution through basal metazoan genomics]]></title_en><user_id>1187</user_id><user_firstLast_name>Kristian Vlahoviček</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2014-09</proposal_call><code>IP-2014-09-6400</code><acronim><![CDATA[BAMGEN]]></acronim><duration>01.10.2015 - 31.12.2019</duration><status>Završio</status><financ_value>132.722,81 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Biologija, </scie_field_hr><scie_field_en>Biology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>1193, 1221, 1228, 1207, 1225, 1208, 1188, 25324, </team_members_id><team_members_names><![CDATA[Helena Ćetković, Andreja Mikoč, Matija Harcet, Helena Bilandžija, Bruna Pleše, Mirna Imešek, Rosa Karlić, Silvestar Beljan, ]]></team_members_names><keywords_hr><![CDATA[regulacija gena, genomika, transkriptomika, spužve, genomika raka]]></keywords_hr><keywords_en><![CDATA[gene regulation, genomics, transcriptomics, sponges, cancer genomics]]></keywords_en><summary_hr><![CDATA[Projekti velikih razmjera koji uključuju metode -omike priskrbili su veliku količinu znanja o molekularnim mehanizmima u stanicama i tkivima ljudi i modelnih organizama, te pružili mnoštvo informacija o raznolikosti staničnih procesa, poglavito genske regulacije. Ti su projekti ujedno razotkrili neizmjernu kompleksnost životinjske stanice, potencijal za diferencijaciju u stanice različitih tkiva, gubitak kontrole pri nastajanju raka, te time potakli niz dubljih pitanja na različitim područjima znanosti o životu: Kako funkcionira diferencijacija u specifične stanice tkiva? Koliko su mehanizmi genske regulacije očuvani kroz životinjsko carstvo? Odakle potječe kompleksnost procesa diferencijacije? I, konačno, koje je porijeklo višestaničnosti?  Bazalne životinje (Metazoa), ključne su za odgovore na ova pitanja: mi na njih namjeravamo odgovoriti proučavanjem ne-modelnih organizama na samom dnu životinjskog evolucijskog stabla - najjednostavnijim višestaničnim životinjama - spužvama (Porifera). Spužve su najstarije danas živuće životinje koje su se vjerojatno najranije odvojile na razvojnom stablu životinja, te posjeduju neka izvanredna svojstva koja ih čine idealnim modelom za istraživanja regulacije gena uključenih u razvoj: u bliskoj su simbozi s jednostaničnim prokariotima, sadrže mali broj osnovnih tipova stanica, nemaju pravih tkiva, organa ni zametnih listića, a istovremeno posjeduju mnoge gene uključene u rani razvoj i povezane s nastankom raka, kao i totipotentne stanice. Metodama komparativne genomike i transkriptomike, htjeli bismo istražiti procese unutar simbioze, kao i procese razvoja i diferencijacije stanica za koje vjerujemo da su naslijedile sve višestanične životinje.  Pomoću čvrste mreže suradnika, stručnjaka u području biologije Metazoa s iskustvom u  metodama genomike i računalne biologije kompleksnih sustava, te preliminarnim setom zanimljivih rezultata, namjeravamo odgovoriti na prethodno postavljena pitanja i interdisciplinarnim pristupom razjasniti neka od ključnih otvorenih pitanja na području genomike i evolucije čitavog životinjskog carstva.]]></summary_hr><summary_en><![CDATA[Large scale –omics projects have provided valuable knowledge on the molecular mechanisms occurring in cells and tissues of human and other related model organisms, delivering a wealth of information on the diversity of cellular processes, and in particular gene regulation. Yet, these projects have also uncovered the immense complexity of the animal cell, its potential to differentiate into various tissues, or spiral out of control by forming cancer, opening up even more profound questions on diverse fronts of the life sciences: How does tissue-specific cell differentiation work? How conserved are gene regulation mechanisms throughout animal kingdom? Where does complexity of differentiation originate from? And, finally, what is the origin of multicellularity?Basal metazoans hold key answers to these questions: we propose to tackle them by investigating the non-model organisms at the very base of the animal evolutionary tree – the simplest multicellular animals – sponges (Porifera). Sponges, are probably the earliest branching and the oldest extant animals. They hold remarkable properties that make them an excellent subject for studying developmental gene regulation: a handful of major cell types, no true tissues and organs, and no germ layers, but at the same time they are rich in early developmental genes associated to cancer and possessing totipotent cells. With the aid of comparative genomics and transcriptomics, we wish to explore developmental and cell differentiation processes that we believe are ancestral to all multicellular animals.With a strong collaboration network, expert base in metazoan biology, expertise in genomics and computational biology of complex systems, and a preliminary set of interesting results, we propose to answer the above questions through a truly interdisciplinary approach and elucidate some of the crucial open questions in genomics and evolution of the entire animal kingdom. ]]></summary_en></project><project>
<id>3402</id><title_hr><![CDATA[Probiotici i starter kulture – površinski proteini i bakteriocini]]></title_hr><title_en><![CDATA[Probiotics and starter cultures – surface proteins and bacteriocins]]></title_en><user_id>798</user_id><user_firstLast_name>Blaženka Kos</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2014-09</proposal_call><code>IP-2014-09-7009</code><acronim><![CDATA[PRO-S]]></acronim><duration>01.07.2015 - 30.06.2019</duration><status>Završio</status><financ_value>75.997,68 eur</financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Biotehnologija, </scie_field_hr><scie_field_en>Biotechnology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prehrambeno-biotehnološki fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Food Technology and Biotechnology]]></institution_en><team_members_id>796, 797, 800, 1011, 13349, 13182, 18967, 799, 21384, </team_members_id><team_members_names><![CDATA[Jasna Beganović, Andreja Leboš Pavunc, Ksenija Uroić, Ksenija Durgo, LJERKA GREGUREK, Katarina Tonković, Martina Marijanović, Jagoda Šušković, Katarina Butorac, ]]></team_members_names><keywords_hr><![CDATA[probiotici, starter kulture, bakteriocini, površinski proteini, funkcionalnost]]></keywords_hr><keywords_en><![CDATA[probiotics, starter cultures, bacteriocins, surface proteins, functionality]]></keywords_en><summary_hr><![CDATA[Svrha predloženog istraživanja je razvoj nove generacije probiotika i funkcionalnih starter kultura, detaljno okarakteriziranih, sa specifičnim svojstvima kao što je proizvodnja funkcionalnih površinskih S-proteina i bakteriocina. Od ukupno dvjesto različitih autohtonih sojeva bakterija mliječne kiseline (BMK), izoliranih iz tradicionalnih fermentiranih proizvoda u Laboratoriju za tehnologiju antibiotika, enzima, probiotika i starter kultura Prehrambeno-biotehnološkog fakulteta Sveučilišta u Zagrebu, samo pet Lactobacillus sojeva eksprimira sloj S-proteina na površini svojih stanica. Istraživanja će se provoditi s ciljem razjašnjavanja uloge S-proteina u stanicama Lactobacillus sojeva, posebno u važnim probiotičkim svojstvima, kao što su adhezija, kompetitivna ekskluzija patogena i interakcije s imunološkim sustavom domaćina. Istraživanja će također biti usmjerena na proizvodnju bakteriocina autohtonih sojeva BMK, mehanizma njihovog djelovanja i indukciju sinteze bakteriocina. Izolirani autohtoni sojevi BMK bit će dalje ispitivani obzirom na fiziološka i tehnološka svojstva važna pri odabiru funkcionalnih starter kultura. Obzirom da su tradicionalno proizvedeni fermentirani proizvodi bogat izvor novih i potencijalno zanimljivih mikrobnih sojeva poželjnih genetičkih, metabolizamskih i tehnoloških svojstava, okarakterizirani sojevi BMK, proizvedeni kao mikroinkapsulirane i liofilizirane funkcionalne starter kulture će doprinijeti kvaliteti i sigurnosti tradicionalnih fermentacijskih procesa kao i formulaciji inovativnih funkcionalnih proizvoda. Oboje je od velikog značaja za prehrambenu industriju s aspekta proizvodnje hrane s posebno definiranim funkcionalnim (probiotičkim) svojstvima.]]></summary_hr><summary_en><![CDATA[The proposed research is aimed to deliver new generation of probiotics and functional starter cultures, thoughtfully characterised and with specific features such as production of functional surface (S)-layer proteins and bacteriocins. Among more than 200 different autochthonous lactic acid bacteria (LAB) strains isolated from artisanal fermented food products in Laboratory of Antibiotic, Enzyme, Probiotic and Starter Culture Technologies, Faculty of Food Technology, University of Zagreb, only five Lactobacillus strains are found to possess S-layer proteins. This research is intended to clarify the role of S-layer proteins in cells of Lactobacillus species, particularly in important probiotic properties such as adhesion, competitive pathogen exclusion and interactions with host immune system. Researches will also be directed towards bacteriocin production by autochthonous LAB strains, mode of antimicrobial action, as well as the induction of bacteriocin production. Isolated autochthonous LAB strains will be further examined for their physiological and technological properties important during their selection as functional starter cultures. Since artisanal fermented foods are a rich source of new and potentially interesting microbial strains with considerable genetic, metabolic and technological properties, well-defined autochthonous LAB strains, produced as microencapsulated and lyophilised functional starter cultures, will contribute to safety and quality of traditional food fermentation processes and to formulate innovative functional products. Both are of great importance for the food industry in aspect of designing the food with specially defined functional (probiotic) properties.]]></summary_en></project><project>
<id>3404</id><title_hr><![CDATA[Genotip-fenotip korelacija u Alportovom sindromu i nefropatiji tankih glomerularnih bazalnim membrana]]></title_hr><title_en><![CDATA[Genotype-Phenotype Correlation in Alport&#39;s syndrome and Thin Glomerular Basement Membrane Nephropathy ]]></title_en><user_id>3902</user_id><user_firstLast_name>Danica Galešić Ljubanović</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2014-09</proposal_call><code>IP-2014-09-2151</code><acronim><![CDATA[GPofASandTBMN]]></acronim><duration>01.09.2015 - 31.08.2019</duration><status>Završio</status><financ_value>128.734,73 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Kliničke medicinske znanosti, Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Clinical sciences, Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb School of Medicine]]></institution_en><team_members_id>4633, 441, 13504, 5270, 7036, 5354, 12463, 5028, 4155, 12795, 4839, 12918, 5847, 5960, 4711, 6514, 3838, 4592, 5842, 5871, 19506, 24835, </team_members_id><team_members_names><![CDATA[Petar Šenjug, Tamara Nikuševa Martić, Nina Canki-Klain, Kristina Meljanac Salopek, Marija Perica, Krešimir Galešić, Danica Batinić, Danko Milošević, Marijana Ćorić, Marijan Saraga, Merica Glavina Durdov, Gordana Đorđević, Ivica Horvatić, Matija Crnogorac, Stela Bulimbašić, Anamarija Bauer Šegvić, Mladen Knotek, Rajko Kušec, Ana Livun, Martin Ćuk, Maja Trupković, Matija Horaček, ]]></team_members_names><keywords_hr><![CDATA[Alportov sindrom, nefropatija tankih glomerularnih bazalnih membrana, COL4A3, COL4A4, COL4A5, genotip-fenotip korelacija]]></keywords_hr><keywords_en><![CDATA[Alport’s syndrome, Thin Glomerular Basement Membrane Nephropathy, COL4A3, COL4A4, COL4A5, genotype-phenotype correlation]]></keywords_en><summary_hr><![CDATA[Alportov sindrom (AS) i nefropatija tankih glomerularnih bazalnih membrana (TBMN) su genetski heterogeni, strukturalni poremećaji glomerularne bazalne membrane (GBM). Genetska osnova obaju poremećaja je u mutaciji gena koji kodiraju izoforme kolegena tipa IV.  Glavni simptom u oba poremećaja (AS i TBMN) je hematurija, a glavna razlika je u kliničkom tijeku i progresiji bolesti. Razlikovanje AS i TBMN je važno, ali ponekad komplicirano. Planiramo provesti multidisciplinarno, kolaborativno istraživanje na nacionalnoj razini, u kojem će sudjelovati sedam vodećih hrvatskih nefroloških, pedijatrijsko-nefroloških i nefropatoloških institucija (Klinička bolnica Dubrava,  Klinička bolnica Merkur, Klinički bolnički centri Zagreb, Rijeka i Split, Klinički bolnički centar Sestre Milosrdnice, Zagreb i Klinika za dječje bolesti, Zagreb). Prikupit ćemo kliničke podatke o bubrežnim i izvanbubrežnim simptomima, histološke podatke (uključujući bojenje za lance kolagena tipa IV) i provesti studiju obitelji za AS i TBMN pacijente u Hrvatskoj. U svrhu otkrivanja mutacija gena COL4A5, COL4A4 i COL4A3 koristit ćemo kombinirani pristup - multipleks PCR amplifikaciju, kvantifikaciju amplikona  i  sekvenciranje slijedeće generacije (eng. next generation sequencing). Ove analize će biti provedene u molekularnom laboratoriju Zavoda za patologiju i Centru za translacijska i klinička istraživanja Medicinskog fakulteta Sveučilišta u Zagrebu. Glavni cilj istraživanja je utvrditi prevalenciju AS i TBMN u Hrvatskoj i razjasniti AS i TBMN histološki, genetski i klinički. Naš krajnji cilj je stvoriti Hrvatski  registar AS i TBMN pacijenta s kliničkim, histološkim i genetskim podacima te podacima o praćenju pacijenata. Voditelj projekta je izv.prof.dr.sc. Danica Galešić Ljubanović, a uz nju, na projektu će sudjelovati 20 znanstvenika.]]></summary_hr><summary_en><![CDATA[Alport&#39;s syndrome (AS) and thin basement membrane nephropathy (TBMN) are genetically heterogenic, structural disorders of glomerular basement membrane (GBM). Genetic base of both disorders lies in mutation of genes which encode isoforms of collagen type IV. Major symptom of both disorders (AS and TBMN) is hematuria, and the main difference between them, is clinical course and progression of the disease. The distinction between AS and TBMN is important but may be difficult. Our plan is to conduct multidisciplinary, nationwide, collaborative research in which seven leading Croatian nephrology, pediatric nephrology and nephropathology institutions (Dubrava University Hospital Zagreb, Merkur University Hospital Zagreb, University Hospital Centers Zagreb, Rijeka and Split, University Hospital Center Sisters of Mercy, Zagreb and Children&#39;s Hospital Zagreb) will participate.  We plan to collect clinical data, about both renal and extra-renal symptoms, histological data (including staining for collagen IV chains), as well as, family study data on Croatian AS and TBMN patients.  The combined approach of multiplex PCR amplification, amplicon quantification, and next generation sequencing for COL4A5, COL4A4 and COL4A3 gene mutation screening will be done at molecular laboratory at Department of Pathology and Center for Translational Research, University of Zagreb. School of Medicine. Main goal of our research is to identify prevalence of AS and TBMN in Croatia and to clarify these two entities histologically, genetically and clinically. Our ultimate goal is to create AS and TBMN patients&#39; registry with clinical, histological, genetic and follow up information. Project leader is Associate Professor Danica Galešić Ljubanović, and beside her, on project will work 20 scientists.]]></summary_en></project><project>
<id>3412</id><title_hr><![CDATA[Istraživanje školskog vođenja iz distributivne perspektive u hrvatskim školama]]></title_hr><title_en><![CDATA[Investigating School Leadership From a Distributed Perspective in Croatian Schools ]]></title_en><user_id>4623</user_id><user_firstLast_name>Branko Rafajac</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2014-09</proposal_call><code>IP-2014-09-1825</code><acronim><![CDATA[IScLEAD]]></acronim><duration>01.05.2015 - 30.04.2018</duration><status>Prekinut</status><financ_value>29.705,21 eur</financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Pedagogija, </scie_field_hr><scie_field_en>Pedagogy, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Filozofski fakultet u Rijeci]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Humanities and Social Sciences]]></institution_en><team_members_id>344, 3032, 13445, 779, 7184, </team_members_id><team_members_names><![CDATA[Vesna Kovač, Nena Rončević, Vjekoslav Robotić, Iva Buchberger, Stjepan  Staničić, ]]></team_members_names><keywords_hr><![CDATA[upravljanje obrazovnim sustavom, distributivno školsko vođenje, učinkovitost škola, jedinice lokalne samouprave, ravnatelji, učitelji, škole]]></keywords_hr><keywords_en><![CDATA[governance of educational system, distributive school leadership, school effectiveness, local educational authorities, school principals, teachers, sc]]></keywords_en><summary_hr><![CDATA[Predloženo istraživanje fokusira se na fenomen školskog vođenja koji se određuje kao jedan od najznačajnijih faktora uspješnosti škola odnosno postignuća učenika, a u širem kontekstu i uspješnosti odnosno održivosti obrazovnih reformi. Glavni cilj istraživanja je identificirati obilježja prakse školskog vođenja u hrvatskim školama s posebnim naglaskom na indikatore individualnog naspram distributivnog vođenja te iznalaženje onih obilježja školskog vođenja koja su povezana s učinkovitosti škola. Glavni cilj istraživanja realizirat će se kroz sljedeće specifične zadatke: 1) Ispitati obilježja školskog vođenja s posebnim naglaskom na ulogu i vrstu participacije i interakcija pojedinih dionika u aktivnostima vođenja (ravnatelja, školskog odbora, učiteljskog/nastavničkog vijeća, stručne službe, učitelja, roditelja, učenika, predstavnika zajednice i lokalne samouprave) i njihove povezanosti s indikatorima školskog uspjeha; 2) Ispitati različita obilježja upravljanja hrvatskim obrazovnim sustavom iz perspektive različitih dionika (komunikacija i suradnja između autoriteta na državnoj razini, razini lokalne samouprave i razini škole; zadovoljstvo načinom funkcioniranja obrazovnog sustava) i njihov efekt na praksu školskog vođenja. Rezultati prijašnjih istraživanja i preliminarni izvještaji povezani s hrvatskim obrazovnim sustavom ukazuju na važnost osnaživanja karakteristika distributivnog školskog vođenja s naglaskom na osnaživanje kapaciteta učitelja kao aktivnih sudionika u procesu donošenja odluka koje se odnose na obrazovanje. ]]></summary_hr><summary_en><![CDATA[The proposed research focuses on the phenomenon of school leadership which is seen as one of the most important success factors of school and student achievement. In the broader context, it is seen as a success i.e. sustainability factor of education reforms. The main aim of this research is to identify the characteristics of the school leadership practice in Croatian schools with the special emphasize on indicators of both solo and distributive leadership and finding those features that are associated with the school and student achievement. The main aim will be elaborated through the following specific tasks: 1) examining the characteristics of school leadership with special emphasis on the role of participation and interaction of individual stakeholders in the activities of leadership (school principals, school boards, school councils, professional services, teachers, parents, students, community representatives and local government) and their association with indicators of school success; 2) examining various features of education system governance from the perspectives of different stakeholders (communication and collaboration between state level, local governments and school level authorities; overall satisfaction with the education system governance) and their effects on the school leadership practice. Results of the previous studies and preliminary review related to Croatian education system point to the importance of strengthening the characteristics of the distributed school leadership with special emphasis on strengthening the capacity of teachers as active participants in making key decisions related to the matters of education.]]></summary_en></project><project>
<id>3414</id><title_hr><![CDATA[Nanokompoziti cinkovog oksida i titanijevog dioksida za fotonaponsku primjenu]]></title_hr><title_en><![CDATA[Zinc Oxide and Titanium Dioxide  Nanocomposites for Photovoltaic Application]]></title_en><user_id>3922</user_id><user_firstLast_name>Andreja Gajović</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2014-09</proposal_call><code>IP-2014-09-9419</code><acronim><![CDATA[ZOTONanoPhotovolt]]></acronim><duration>01.09.2015 - 31.08.2018</duration><status>Završio</status><financ_value>89.162,92 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, Kemija, </scie_field_hr><scie_field_en>Physics, Chemistry, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>3012, 12522, 12524, 12832, 1271, 5657, 3932, 1338, 12532, </team_members_id><team_members_names><![CDATA[Davor Gracin, Krunoslav Juraić, Daniel Meljanac, Jelena Macan, Nikša Krstulović, Krešimir Salamon, Milivoj Plodinec, Vilko Mandić, Silvije Domazet, ]]></team_members_names><keywords_hr><![CDATA[cinkov oksid, titanijev dioksid, nanokompoziti, fotonaponski uređaji, kemijske metode, magnetronsko rasprašivanje,  pulsna laserska depozicija]]></keywords_hr><keywords_en><![CDATA[zinc oxide, titanium diokside, nanocomposites, photovoltaic solar cells, chemical methods, magnetrons sputtering and pulsed laser deposition]]></keywords_en><summary_hr><![CDATA[Istraživat će se mogućnosti modificiranja svojstava tankih filmova metalnih oksida, prvenstveno ZnO  i TiO2, podešavanjem njihove nano-strukture i aktiviranjem njihove površine. Svojstva će se optimirati primarno za upotrebu u fotonaponskim uređajima no rezultati će biti primjenjivi i za druge opto-električne uređaje, razne vrste senzora, katalizatora itd. Pri tom će se određivati korelacija (nano)strukturnih osobina sa optičkim, vibracijskim i električnim osobinama s jedne strane te ovisnost strukture o parametrima formiranja sa druge. Ovo će omogućiti provjeru teoretskih predviđanja vezanih za defekte i nisko-dimenzionalne strukture i modeliranje rasta tankih filmova. Nastojat će se realizirati nano-strukture koje su izdužene u smjeru okomitom na površinu,  sastoje se od jedne vrste oksida a dekorirane su drugom vrstom oksida. Od njih se očekuje značajno povećanje efikasnosti fotonaponskih ćelija. Tehnike priprave će biti: (i) kemijske metode, (ii) vakuumske depozicije pomoću magnetronskog rasprašivanja i pulsne laserske depozicije (PLD). Kemijske metode (uključujući sol-gel tehnike i hidrotermalnu sintezu) ostavljaju velike mogućnosti u formiranju raznih nano-struktura (npr. nano-kristali, nano-žice, nano-plohe, nano-cjevčice) i olakšavaju veću fleksibilnost pri optimizaciji priprave te bolju statistiku u određivanju povezanosti  nano-strukture sa svojstvima. S druge strane, fotonaponske solarne ćelije podrazumijevaju formiranje slojeva na velikim površinama pa razne tehnike formiranja kao što su magnetronska depozicija i PLD imaju evidentnu prednost. Također, obrada površine plazmom je prirodno povezana sa magnetronskom depozicijom i PLD. Zbog toga će se posebna pažnja posvetiti ovim dvjema tehnikama. Optimalne strukturna svojstva, koji će se eksperimentalno potvrditi kombinacijom kemijskih metoda, će se nastojati postići magnetronskom depozicijom i PLD.Projekt će dijelom bit posvećen edukaciji doktorskih i postdoktorskiih studenta. ]]></summary_hr><summary_en><![CDATA[The possibility of modification the properties of thin film metal oxides , primary ZnO and TiO2,  by adjusting nano-structure and by activation of surfaces will be explored. The properties will be primary adjusted for use in photovoltaic solar cells while results will be applicable for other opto-electronic devices, sensors, catalysts etc.Project activities assume study of correlation between details of (nano)structural properties with optical, vibrational and electrical from one side and correlation between structure and parameters of deposition from other side. This will enable test of theoretical predictions related to defects and low dimensional structures and models of thin film growth as well. The main challenge is nano-structures elongated in the direction perpendicular to the surface, based on one type of oxide while decorated with other type of oxide. By using these structures significant increase the efficiency of photovoltaic cells is expected.Two basic preparation techniques will be used: (i) chemical methods and (ii) vacuum deposition by magnetrons sputtering and pulsed laser deposition (PLD). The chemical methods (including sol-gel technique and hydrothermal syntheses) enable relatively simple formation of various nano-structures (e. g. nano-crystals, nano-wires, nano-sheets, nano-tubes) providing larger flexibility for optimization of the preparation, and better statistics for understanding the correlation between nano-structure and properties. On the other hand, photovoltaic solar cells assume deposition of the films on large areas and for this purpose magnetron sputtering and PLD seem more suitable. Furthermore, the surface modification by plasma treatment looks appealing in combination with vacuum deposition techniques or PLD. That is why the optimal structural properties found by chemical methods will be goal to be obtained by magnetron sputtering or PLD techniques. Project will be partially devoted to education of the PhD and Postdoc. students.]]></summary_en></project><project>
<id>3415</id><title_hr><![CDATA[Iznad Nyquistove granice]]></title_hr><title_en><![CDATA[Beyond the Nyquist limit]]></title_en><user_id>6982</user_id><user_firstLast_name>Damir Seršić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2014-09</proposal_call><code>IP-2014-09-2625</code><acronim><![CDATA[BeyondLimit]]></acronim><duration>01.10.2015 - 30.09.2019</duration><status>Završio</status><financ_value>129.802,91 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Elektrotehnika, Računarstvo, </scie_field_hr><scie_field_en>Electrical engineering, Computer sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id>6945, 6991, 6592, 21316, 22636, 25370, 17809, </team_members_id><team_members_names><![CDATA[Mladen Vučić, Davor Petrinović, Ana Sović, Maja Jurišić Bellotti, Ivan Ralašić, Nikola Vrebčević, Matea Đonlić, ]]></team_members_names><keywords_hr><![CDATA[pod-Nyquistovsko uzorkovanje, sažimajuće očitavanje, kauzalni splajnovi, rijetke reprezentacije, adaptivni valići, napredni dizajn sustava]]></keywords_hr><keywords_en><![CDATA[sub-Nyquist sampling, compressive sensing, causal splines, sparse representations, adaptive wavelets, advanced system design]]></keywords_en><summary_hr><![CDATA[Moderne informacijske i komunikacijske tehnologije suočene su s nizom izazova. Među njima izdvojili smo dva važna: ogromnu količinu podataka koja dolazi iz realnog svijeta putem senzora, kao i snagu računala potrebnu za njihovu obradu. U ovom projektnom prijedlogu smo se usmjerili na oba navedena izazova, kao i na napredne primjene ponuđenih rješenja.Desetljećima, Nyquistova granica postavlja doseg rada digitalnih elektroničkih sustava koji djeluju u analognom svijetu. Korištenjem našeg prethodnog istraživanja u području kauzalnih splajnova, adaptivnih valića, rijetkih reprezentacija te naprednog dizajna sustava, razvit ćemo originalni sustav koji radi iznad Nyquistove granice. Pod-Nyquistovsko uzorkovanje u uniji analognih potprostora te sažimajuće očitavanje su područja istraživanja korištena za postizanje ovog cilja. Obje tehnike rezultiraju aplikacijama koje idu preko poznatih granica: rezultiraju u novim tehnikama prikupljanja i obrade slika, naprednim radarskim i sonarskim uređajima, širokopojasnom programski definiranom radiju, kao i naprednim sustavima za obradu govornih i audio signala. Oslanjaju se na rijetke reprezentacije signala, sofisticiranu rekonstrukciju i algoritme za obradu signala, kao i na inteligentne implementacije koje kombiniraju analogne i digitalne podsustave.Istraživači okupljeni u ovom projektnom timu imaju iskustvo u modeliranju rijetkim signalima, dizajnu naprednih analognih i digitalnih sustava, a razvili su i različite aplikacije u obradi slika, audio i govornih signala. Razvit ćemo originalan sustav iznad Nyquistove granice zasnovan na našim kauzalnim splajnovima. Koristit ćemo naše adaptivne sustave i brze L1 minimizacijske algoritme radi postizanja rijetkih reprezentacija potrebnih u sažimajućem očitavanju. Rezultati će se koristiti u dizajnu novog pod-Nyquistovog sustava, čija će se realizacija oslanjati na naš napredni dizajn. Razvit ćemo aplikacije u obradi 3D signala, slika te obradi audio i govornih signala.]]></summary_hr><summary_en><![CDATA[Modern information and communication technologies face various challenges. We identified two of them as important: huge amount of data delivered from the real world via sensing devices, and computing power required for its processing. Both challenges are targeted in our project proposal, as well as some advanced applications of the proposed solutions.For decades, Nyquist limit sets the achievable work range of digital electronic systems operating in an analogue world. Using our previous research and expertise in causal splines, adaptive wavelets, sparse representations, and advanced system design, we will develop an original system that works beyond the Nyquist limit. Sub-Nyquist sampling in a union of analogue subspaces and compressive sensing are research topics used to achieve this goal. Both approaches result in applications that go beyond the known limits: they result in novel imaging techniques, advanced radar and sonar devices, wide-band software defined radios, as well as in advanced speech and audio processing systems. They rely on sparse representation of signals, sophisticated reconstruction and signal processing algorithms, as well as on intelligent hardware implementations that mix analogue and digital subsystems. The researchers gathered in this project team have research experience in causal splines, adaptive wavelets and sparse signal modeling, as well as in design of advanced analogue and digital systems. They have developed various applications in image, audio and speech signal processing. We will develop an original beyond Nyquist system based on our causal splines. We will use our adaptive systems and fast L1 minimization algorithms to achieve sparse representations needed in compressive sensing. The results will be used in design of novel sub-Nyquist systems, whose realization will rely on our advanced system design. We will develop its applications in 3D, image, audio and speech signal processing.]]></summary_en></project><project>
<id>3416</id><title_hr><![CDATA[Brendiranje Turističke Destinacije: Analiza Uspješnosti Brenda u Kontekstu Procesa Brendiranja Destinacije ]]></title_hr><title_en><![CDATA[The Branding of Tourism Destinations: Looking at Brand Performance in the Context of the Destination Branding Process ]]></title_en><user_id>1363</user_id><user_firstLast_name>Josip Mikulić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2014-09</proposal_call><code>UIP-2014-09-7005</code><acronim><![CDATA[DESTBRAND]]></acronim><duration>01.07.2015 - 30.06.2019</duration><status>Prekinut</status><financ_value>35.235,89 eur</financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Ekonomija, </scie_field_hr><scie_field_en>Economy, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Ekonomski fakultet u Zagrebu]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Economics and Business]]></institution_en><team_members_id>217, 5771, 878, 6272, 6616, 13555, </team_members_id><team_members_names><![CDATA[Damir KREŠIĆ, Petra BARIŠIĆ, Maja ŠERIĆ, Darko PREBEŽAC, Katarina MILIČEVIĆ, IRENE GIL-SAURA, ]]></team_members_names><keywords_hr><![CDATA[turizam, destinacija, marketinški menadžment, vrijednost marke/brenda, proces kreiranja marke/brendiranja, model ]]></keywords_hr><keywords_en><![CDATA[tourism, destination, marketing management, brand equity, brand buidling process, model]]></keywords_en><summary_hr><![CDATA[Suvremena istraživanja iz područja turizma naglašavaju potrebu kreiranja marke turističke destinacije (u nastavku će se rabiti izraz: brendiranje) i stvaranje vrijednosti destinacijske marke (u nastavku će se rabiti izraz: brend) kao preduvjet održive tržišne pozicije u vremenima sve veće tržišne saturacije i konkurencije. Istodobno, istraživači naglašavaju kako se ovdje radi o izuzetno složenim procesima. Međutim, do sada je provedeno tek nekoliko empirijskih istraživanja koja su se bavila konceptom brenda turističke destinacije, a u svojem pristupu postojeća istraživanja su usko fokusirana, te su ograničena samo na pojedine aspekte brendiranja i vrijednosti brenda. Cjelovita i sustavna istraživanja na temu vrijednosti destinacijskog brenda, koja uključuju njegove determinante i učinke, gotovo da ne postoje. Iako je nekoliko istraživača iz područja turizma predložilo modele za mjerenje vrijednosti brenda, većina je tih studija ograničeno na hotelijerstvo, dok je problematika stvaranja vrijednosti brenda turističke destinacije do sada bila relativno zanemarena. Sukladno tome, jedan je od glavnih ciljeva ovog projekta je razvoj cjelovitog modela vrijednosti destinacijskog brenda koji uključuje njegove relevantne determinante i učinke. Nadalje, iako postoji cijeli niz istraživanja koja se intenzivno bave analizom pojedinih determinanti vrijednosti brenda destinacije, kao što su npr. svjesnost o brendu, imidž brenda, kvaliteta/atraktivnost destinacije, ili lojalnost mjestu/destinaciji, tek je manji broj istraživanja pokušao uspostaviti vezu između prakse brendiranja koju provode organizacije za destinacijski menadžment, s jedne strane, i učinaka procesa brendiranja mjerenih razinom performansi brenda, s druge strane. Pojašnjenje  ove sprege pomoglo bi uspostavljanju smjernica najbolje, ili u najmanju ruku bolje prakse s područja brendiranja turističke destinacije. ]]></summary_hr><summary_en><![CDATA[Several researchers highlight the importance of branding tourism destinations and building destination brand equity as a prerequisite for achieving a sustainable market position on an increasingly saturated and competitive market. Meanwhile, researchers also acknowledge the complexity of these processes. Empirical research on the destination brand concept has, however, so far been rather scarce and fragmented. Moreover, comprehensive and systematical research of destination brand equity, encompassing the individual determinants-antecedents and outcomes-consequences, are almost completely lacking. Although a number of researchers have proposed models for measuring brand equity in tourism, these contributions were mainly limited to the hotel industry, while brand-equity building in the context of destinations is rather neglected. Accordingly, developing a comprehensive model of destination brand equity, which integrates both important antecedents and consequences, is one important research gap this project aims to address and fill. Moreover, while several antecedents of destination brand equity have been studied in particular detail, like e.g. brand awareness, brand image, destination quality/attractiveness, or most recently place attachment, very few studies have, in fact, tried to establish a connection between branding practices of destination management organizations and the aimed, as well as the truly achieved, outcomes of these practices. Accordingly, as the first of its kind, the proposed project aims to shed light on the relationship between the destination branding process, on the one hand, and the outcome of this process in terms of brand performance levels, on the other hand. Insight into this relationship should help to establish best or, at least, better practice guidelines for the branding of tourism destinations.]]></summary_en></project><project>
<id>3421</id><title_hr><![CDATA[Izvori, pomagala i studije za hrvatsku povijest od srednjeg vijeka do kraja dugog 19. stoljeća]]></title_hr><title_en><![CDATA[Sources, Manuals and Studies for Croatian History from the Middle Ages to the End of the Long Nineteenth Century]]></title_en><user_id>3017</user_id><user_firstLast_name>Damir Karbić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2014-09</proposal_call><code>IP-2014-09-6547</code><acronim><![CDATA[IZVORISRV19ST]]></acronim><duration>01.06.2015 - 31.05.2019</duration><status>Završio</status><financ_value>67.237,37 eur</financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Povijest, </scie_field_hr><scie_field_en>History, </scie_field_en><institution_hr><![CDATA[Hrvatska akademija znanosti i umjetnosti]]></institution_hr><institution_en><![CDATA[Croatian Academy of Sciences and Arts]]></institution_en><team_members_id>3006, 2525, 1535, 4085, 4071, 3036, 1534, 4892, 382, 418, 5605, 6151, 6145, 13552, 13178, 5315, 5727, 6488, 4169, 5546, 4469, </team_members_id><team_members_names><![CDATA[Zoran Ladić, Tihana Luetić, Branka Grbavac, Sabine Florence Fabijanec, Suzana Miljan, Goran Budeč, Iva Kurelac, Vesna Tudjina, Lovorka Čoralić, Filip Novosel, Ivan Jurković, Mirjana Matijević Sokol, Tomislav Galović, Krisztina Arany, Judit  Gal, Éva Bátoriné Halász, Zrinka Novak, Mirko Sardelić, Robert Kurelić, Christopher Nicholson, Martyn Rady, ]]></team_members_names><keywords_hr><![CDATA[povijesni izvori, pomoćne povijesne znanosti, društvena povijest, gospodarska povijest, normativni pravni izvori]]></keywords_hr><keywords_en><![CDATA[historical sources, auxiliary disciplines of history, social history, economic history, legal normative sources]]></keywords_en><summary_hr><![CDATA[Opći cilj projekta je priupljanje, znanstvena analiza i izdavanje izvora za društvenu, kulturnu i gospodarsku povijest Hrvatske od srednjeg vijeka do kraja dugog 19. st., izrada priručnika potrebnih za njihovo istraživanje, te, na njihovom temelju, pisanje studija (članaka i monografija) koji se tiču, u prvom redu, društvene i gospodarske povijesti Hrvatske. To je jedan od projekata koji su se razvili iz istraživanja koja se već tradicionalno provode u istraživačkom okviru Odsjeka za povijesne znanosti Zavoda za povijesne i društvene znanosti Hrvatske akademije znanosti i umjetnosti. Prvenstveni cilj rada na projektu je priprema i objavljivanje kritičkih izdanja izvora potrebnih drugim istraživačima za njihova daljnja istraživanja. Cilj mu je dopunjavanje i kompletiranje starijih izdanja izvora novim arhivskim istraživanjima i nastavljanje već uspostavljenih zbirki, ali i uspostavljanje nekih novih i započinjanje njihovog publiciranja. Pažnja će biti posvećena i proučavanju starije (u prvom redu one ranonovovjekovne) historiografije ao izvora za društvenu, političku, gospodarsku i kulturnu povijest. Istraživački rad na projektu rezultirati će novim izdanjima povijesnih izvora kvalitetno i kritički pripremljenim i njima opskrbiti hrvatsku i međunarodnu znanstvenu javnost, ako i s nužno potrebnim priručnicima. Metodologija korištena tijekom rada na tim zadacima biti će ona uobičajena za slična istraživanja (utemeljena na općim načelima egdotike i drugih pomoćnih povijesnih disciplina). Uključivanjem u rad mlađih istraživača i kroz suradnju s drugim ustanovama, pomoći će se obrazovanje i trening mlađih znanstvenika. Rezultati rada na projektu biti će predstavljeni znanstvenoj javnosti i putem znanstvenih studija objavljenih u Akademijinim izdanjima i izvan njih u Hrvatskoj i inozemstvu, kao i sudjelovanjem u i organiziranjem važnih znanstvenih skupova i drugih znanstvenih događanja u zemlji i inozemstvu.]]></summary_hr><summary_en><![CDATA[General aim of the project is collecting, scholarly analysing and editing of sources for social and economic history of Croatia from the Middle Ages to the end of the long 19th century, creating manuals needed for research of them, and, based on their research, writing studies (articles, monographs) regarding in the first place social and economic history of Croatia. It is one of the projects evolved from the research already traditionally conducted within the research framework of the Division of Historical Studies of the Institute of Historical and Social Studies of CASA. Primary goal of the work on the project is preparation and publishing of critical editions of sources needed for other researchers for their further research. It is aimed on adding and completing older editions of sources by new archival research and continuation of already established collections and on establishing some new ones and starting their publishing. Attention will be dedicated also to the study of former historiography as a source for social, political, economic and cultural history. Research on the project will result in new editions of sources providing Croatian and international scholarly audience historical sources prepared qualitatively and with criticism, as well as with desperately needed manuals. Methodology used during the work on these tasks will be that usual for such research (based on the general principles of the egdotics and other auxiliary disciplines). By including in work young researchers and through the cooperation with other institutions, it will also help to the education and training of younger scholars. The results of the work on the project will be presented to scholarly public also as studies published within the Academy editions and outside of them in Croatia and abroad, and by participation and organisation of important scholarly conferences and other events in the country and abroad.]]></summary_en></project><project>
<id>3427</id><title_hr><![CDATA[Eksperimentalno istraživanje, optimizacija i karakterizacija rada klipnog motora uz &#39;&#39;dual-fuel&#39;&#39; izgaranje]]></title_hr><title_en><![CDATA[Experimental research, optimization and characterization of piston engine operation with dual-fuel combustion]]></title_en><user_id>11160</user_id><user_firstLast_name>Darko Kozarac</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2014-09</proposal_call><code>IP-2014-09-1089</code><acronim><![CDATA[DUFCOROC]]></acronim><duration>01.09.2015 - 31.08.2019</duration><status>Završio</status><financ_value>123.494,59 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Strojarstvo, Tehnologija prometa i transport, </scie_field_hr><scie_field_en>Mechnical engineering, Transport technology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet strojarstva i brodogradnje]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Mechanical Engineering and Naval Architecture]]></institution_en><team_members_id>13468, 13461, 13464, 13457, 13456, 17793, </team_members_id><team_members_names><![CDATA[Momir Sjerić, Petar Ilinčić, Rudolf Tomić, Mladen Božić, Ante Vučetić, Mario Sremec, ]]></team_members_names><keywords_hr><![CDATA[dual-fuel, prirodni plin, diesel, izgaranje, optimizacija, značajke rada, emisije]]></keywords_hr><keywords_en><![CDATA[dual-fuel, natural gas, diesel, combustion, optimization, performance, emissions]]></keywords_en><summary_hr><![CDATA[Svrha istraživanja je istražiti mogućnosti korištenja prirodnog plina (CNG) u motorima s unutarnjim izgaranjem s naglaskom na „dual-fuel“ motore. „Dual-fuel“ motori su modificirani motori s kompresijskim paljenjem (Diesel motori) kod kojih se CNG koristi kao glavno gorivo, a njegovo izgaranje se inicira ubrizgavanjem male količine dizelskog goriva. „Dual-fuel“ izgaranje ima karakteristike izgaranja motora s kompresijskim paljenjem ali i onih sa stranim paljenjem. Korištenje CNG-a kao djelomični dodatak dizelskom gorivu predložen je zbog čišćeg izgaranja, široke dostupnosti te potencijala za smanjenje globalne (CO2) i lokalne (NOx, čađa) emisije ispušnih plinova iz klipnih motora.Glavni cilj istraživanja je istražiti ostvarive performanse i emisije motora s unutarnjim izgaranjem koji radi s „dual-fuel“ izgaranjem. Za određivanje granica rada motora biti će provedena optimizacija određenih radnih parametara, a sve s ciljem iskorištenja svih teoretskih prednosti „dual-fuel“ izgaranja, u cijelom radnom području motora. Budući da je inicijalni pregled literature pokazao da motori koji rade s „dual-fuel“ izgaranjem imaju određenih problema pri malim i velikim opterećenjima, posebna pozornost bit će posvećena istraživanju mogućem upravljanju rada u tim radnim područjima. Stoga će biti ispitan i HCCI (Homogeneous Charge Compression Ignition) način izgaranja s dva goriva (CNG i dizelsko gorivo) uz povrat hladnih i toplih ispušnih plinova.Kako bi se ostvarili ciljevi istraživanja potrebno je napraviti specifične modifikacije postojećeg eksperimentalnog postava. Nakon toga, provesti će se ciljani eksperimenti te će radni parametri motora biti optimirani u skladu s kriterijima za postizanje najveće korisnosti uz zadovoljavanje kriterija postavljenih na emisiju ispušnih plinova. Stvarne značajke rada realnog motora biti će dobivene pomoću simulacijskog modela koji će imati sve potrebne elemente, a koristiti će eksperimentalne podatke za opis procesa izgaranja.]]></summary_hr><summary_en><![CDATA[The purpose of the research is to investigate the possibilities of utilizing natural gas (CNG) in the internal combustion engine with the focus on dual-fuel engines. Dual-fuel engines are modified compression-ignition (Diesel) engines, where CNG is used as the main fuel which is ignited by a small amount of Diesel fuel. Dual-fuel combustion shares characteristics with both compression-ignition and spark-ignition combustion. The use of CNG as a partial supplement for Diesel fuel has been suggested due to the cleaner nature of combustion, its worldwide availability and its potential to reduce both global (CO2) and local (NOx, soot) exhaust gas emissions from piston engines.The main objective of the research is to investigate the possible performance and emissions of an IC engine running under dual-fuel combustion mode. To obtain the boundaries of engine operation the optimization of specific operating parameters will be made in order to take the full advantage of all theoretical benefits of dual-fuel combustion, in the entire engine operating range. Since the initial literature review showed that dual-fuel engines have certain problems at low and high operating loads, special emphasis will be put in research of operating options in these regimes. Therefore, HCCI (Homogeneous Charge Compression Ignition) with two fuels (CNG and Diesel) and cold and warm EGR operation will be examined.In order to reach the research objectives, it is necessary to make appropriate modifications on the existing experimental setup. Following the modifications, appropriate experiments will be performed, after which the engine parameters will be optimized with the criteria to maximize the efficiency, while satisfying appropriate exhaust gas emissions. Given the results will be obtained from an experimental setup, the real engine performance will be evaluated by a simulation model that features all necessary engine components but uses the combustion performance data from experimental engine.]]></summary_en></project><project>
<id>3431</id><title_hr><![CDATA[Velebit od vrha do dna - multidisciplinarno istraživanje seizmoloških značajki i tektonike područja Velebita]]></title_hr><title_en><![CDATA[Velebit top to bottom – multidisciplinary research linking seismological data and tectonics in the Mt. Velebit region]]></title_en><user_id>37</user_id><user_firstLast_name>Marijan Herak</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2014-09</proposal_call><code>IP-2014-09-9666</code><acronim><![CDATA[VELEBIT]]></acronim><duration>01.06.2015 - 31.05.2019</duration><status>Završio</status><financ_value>132.191,92 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Geofizika, </scie_field_hr><scie_field_en>Geophysics, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>7702, 39, 12953, 40, 199, 12406, 208, 210, 282, 281, 12913, 12922, 12912, </team_members_id><team_members_names><![CDATA[Bruno Tomljenović, Davorka Herak, Igor Vlahović, Snježana Markušić, Josip Stipčević, Bojan  Matoš, Iva Dasović, Ivo Allegretti, Ivica Sović, Ines Ivančić, Snježan Prevolnik, Krešimir Kuk, Tomislav Fiket, ]]></team_members_names><keywords_hr><![CDATA[seizmologija, seizmičnost, seizmotektonika, potres, funkcije prijemnika, tomografija, atenuacija, anizotropija, potresna opasnost]]></keywords_hr><keywords_en><![CDATA[seismology, seismicity, seismotectonics, earthquake, receiver functions, tomography, attenuation, anisotropy, earthquake hazard]]></keywords_en><summary_hr><![CDATA[Seizmičnost šireg područje Velebita znatno je manja one u susjednim regijama prema SZ i JI. Instrumentalno zabilježeni potresi su plitki i slabi do umjereni. Nisku razinu seizmičke aktivnosti ovoga područja nije moguće uvjerljivo objasniti niti jednim od predloženih tektonskih modela cirkum-jadranske regije, prema kojima ova zona niske seizmičnosti ne bi trebala postojati! Predlažemo provesti multidisciplinarno seizmološko i tektonsko istraživanje, koje uključuje i postavljanje guste mreže seizmografa čiji bi podaci trebali omogućiti lociranje žarišta te račun mehanizama i za slabe potrese, analizu funkcija prijemnika, tomografiju pomoću mikroseizmičkog nemira, te procjenu atenuacije i anizotropije. Zajedno s tektonskim istraživanjima koja će omogućiti izradu geoloških profila te rekonstrukciju tektonske evolucije i polja paleo-naprezanja, nadamo se približiti odgovorima na sljedeća pitanja: - Je li niska seizmičnost u okolici Velebita samo privremena, ili je to značajka povezana sa seizmotektonikom toga prostora? Je li seizmički hazard tamo potcijenjen? - Postoji li uopće reversni Velebitski rasjed koji se smatra glavnom seizmogenom strukturom u ovome dijelu vanjskih Dinarida? Ako da, gdje je, kakva su mu geometrijska i kinematička svojstva i je li još uvijek aktivan? - Koji su rasjedi u području Velebita seizmogeni? - Možemo li povezati prividni manjak seizmičnosti s dubokim strukturama, tj. s nepostojanjem subduciranog dijela Jadranske mikroploče ispod ovog dijela Dinarida, ili je to posljedica drugačije kinematičke prošlosti? - Kakva je uloga litosfernih procesa u širem području Velebita u sveukupnom razvoju Dinarida i kako se oni povezani sa sadašnjim tektonskim procesima? - Možemo li poboljšati znanje o topografiji Mohorovičićevog diskontinuiteta? - Što prostorna razdioba grupnih brzina površinskih valova govori o vertikalnoj razdiobi brzina prostornih valova? - Razlikuju li se atenuacijska i anizotropna svojstva području Velebita i u susjednim područjima?]]></summary_hr><summary_en><![CDATA[The area of proposed multidisciplinary research covers a part of the External Dinarides in Croatia centred at Mt. Velebit. This area exhibits conspicuously lower seismicity than the neighbouring regions to the NW and to the SE. Recorded earthquakes are shallow and weak. The apparent low level of seismic activity here is not readily explainable by the proposed tectonic models of the circum-Adriatic area, according to which this quiescent region is not expected to exist at all! We propose to undertake seismological and tectonic study involving installation of a dense seismograph network whose data should enable accurate location and FPS computation for weak events, receiver function analyses, ambient noise tomography, investigation of attenuation and anisotropy, etc. Together with tectonic survey which will enable construction of geological cross-sections and reconstruction of tectonic evolution and  paleo-stress fields we hope to get closer to answering the following questions: - Is the low-seismicity gap that we observe in the Mt. Velebit region a seismic quiescence, or is it a feature related to seismotectonics? Is the seismic hazard underestimated? - Does the Velebit thrust, which is considered as the major seismogenic fault, exist or not? If so, where is it located, what are its geometry and kinematics and is it still active and potential seismogenic source? - Which are seismogenic fault sources in the Mt. Velebit area?- Can we link apparent seismic gap with the deep structures i.e. the missing subduction slab under this area, or is it related to a different kinematic history of this area?- What roles do the lithospheric processes under the Velebit area play in the development of the Dinarides?- Can we improve our knowledge on the Moho-topography?- What does the surface-wave group velocity spatial distribution tell us about the velocity structure?- Do the attenuation or anisotropy properties in the Mt. Velebit region differ from those in the neighbouring areas?]]></summary_en></project><project>
<id>3434</id><title_hr><![CDATA[Divlja loza (Vitis vinifera subsp. sylvestris): vrijedan izvor gena za oplemenjivanje vinove loze]]></title_hr><title_en><![CDATA[The wild grape (Vitis vinifera subsp. sylvestris): a valuable source of genes for grapevine breeding]]></title_en><user_id>1507</user_id><user_firstLast_name>Goran Zdunić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2014-09</proposal_call><code>UIP-2014-09-9737</code><acronim><![CDATA[WI.GRA.GENE]]></acronim><duration>01.07.2015 - 30.06.2018</duration><status>Završio</status><financ_value>79.023,16 eur</financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Poljoprivreda, Šumarstvo, Biotehnologija, Prehrambena tehnologija, </scie_field_hr><scie_field_en>Agriculture, Forestry, Biotechnology, Food technology, </scie_field_en><institution_hr><![CDATA[Institut za jadranske kulture i melioraciju krša]]></institution_hr><institution_en><![CDATA[Institute for Adriatic Crops and Karst Reclamation in Split]]></institution_en><team_members_id>2795, 2826, 2976, 1182, 3132, 3236, 3501, 4236, 13761, 21312, </team_members_id><team_members_names><![CDATA[Ana Mucalo, Tomislav Radić, Maja Žulj Mihaljević, Irena Budić-Leto, Edi Maletić, Katarina Hančević, Lukrecija Butorac, Marijo Leko, Erika  Maul, Katarina Lukšić, ]]></team_members_names><keywords_hr><![CDATA[divlja loza, SSR markeri, domestikacija, ampelografija, genetika]]></keywords_hr><keywords_en><![CDATA[wild grape, SSR markers, domestication, amperlography, genetic]]></keywords_en><summary_hr><![CDATA[Divlja loza (Vitis vinifera subsp. sylvestris Gmel.) predak kultivirane vinove loze nikad nije detaljno istražena u Hrvatskoj. Prirodno stanište ove ugrožene europske biljke (prema IUCN Crvenoj listi ugroženih biljnih vrsta) je relativno netaknuta šuma u neposrednoj blizini vode. Genetska sličnost divlje i kultivirane loze je vrlo visoka (uključujući seksualnu kompatibilnost) iako divlja loza nije pretrpjela strog selekcijski proces domestifikacije. Dakle, tu postoje jedinstvene osobine i aleli još uvijek prisutni u genomu divlje loze, koje treba istražiti i koristiti u suvremenom cijepljenju vinove loze. Glavni ciljevi ovog projekta su i) procijeniti genetsku i fenotipsku raznolikost divlje loze u istraživanoj regiji i njihovu povezanost sa autohtonim sortama vinove loze u uzgoju, ii) sačuvati genetsku raznolikost, iii) istražiti neke morfološke i genetske karakteristike divlje loze koje su od posebnog interesa u programima cijepljenja i mogu pomoći u transferu određenih korisnih gena koji nisu bili cijenjeni tijekom domestifikacije i selekcije od strane ljudi jedinstven je doprinos ovog područja istraživanja. Ovaj projekt će omogučiti osnivanje genetskog laboratorija za DNA karakterizaciju vinove loze na IJK, okupljanje tima znanstvenika usmjerenih na divlju lozu omogućava multidisciplinarni uvid i povečanje vidljivosti i suradnje hrvatske istraživačke grupe sa međunarodnom znanstvenom zajednicom za lozne genetske resurse i istraživačku suradnju.]]></summary_hr><summary_en><![CDATA[The wild grapevine (Vitis vinifera subsp. sylvestris Gmel.) is an ancestor of cultivated grapevine and has never been explored in detail in Croatia. Natural native habitats for this endangered European plant (according to the IUCN Red list of threatened plant species) are relatively untouched forest with significant nearby water. The genetic similarity between wild and cultivated grapes is very high (including sexual compatibility) although the wild grape has not passed through the strict selection process of domestication. Thus, there are possible unique traits and alleles still present in the wild grape genome, which should be explored and used in modern grapevine breeding. The main objectives of this project are to i) assess the overall genetic and phenotypic diversity of wild grape in this region and their relatedness to local cultivated grapevine, ii) preserve the genetic diversity, iii) investigate some morphological and genetic characteristics of wild grape that are of special interest to breeding programs to aid transfer of certain beneficial genes that were not favoured during domestication and human selection bringing unique contribution to this research field. This project will enable the installation of a genetic laboratory for grapevine DNA characterization at the IAC, gather a team of scientists focused on wild grape to deliver multidisciplinary insight, and increase the visibility and collaboration of this Croatian research group with the international scientific community for grape genetic resources, and research collaboration.]]></summary_en></project><project>
<id>3436</id><title_hr><![CDATA[Houses, Roads & Traders of the Early European Civilization]]></title_hr><title_en><![CDATA[Houses, Roads & Traders of the Early European Civilization]]></title_en><user_id>8198</user_id><user_firstLast_name>Marcel Burić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2014-09</proposal_call><code>UIP-2014-09-7131</code><acronim><![CDATA[HRTEC]]></acronim><duration>20.06.2015 - 19.06.2018</duration><status>Prekinut</status><financ_value>66.559,69 eur</financ_value><scie_area_hr>Humanističke znanosti, Prirodne znanosti, Biomedicina i zdravstvo, </scie_area_hr><scie_area_en>Humanities, Natural sciences, Biomedicine and health sciences, </scie_area_en><scie_field_hr>Arheologija, Fizika, Kemija, Biologija, Sociologija, </scie_field_hr><scie_field_en>Archeology, Physics, Chemistry, Biology, Sociology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Filozofski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Humanities and Social Sciences]]></institution_en><team_members_id>13009, 12907, 13548, 11234, 13027, 12960, </team_members_id><team_members_names><![CDATA[David Orton, Anne de Vareilles Sommieres, Tihomila Težak-Gregl, Jelena Lapić, Mateja Hulina, Zdravka Hincak, ]]></team_members_names><keywords_hr><![CDATA[Kasni neolitik, istočna Hrvatska, Bapska, Bogdanovci, višeslojno naselje, socijalna struktura, interdisciplinarne analize]]></keywords_hr><keywords_en><![CDATA[The Late Neolithic Period, Eastern Croatia, Bapska, Bogdanovci, tell, Social structure, Interdisciplinary approach]]></keywords_en><summary_hr><![CDATA[Projekt Houses, Roads & Traders of the Early European Civilization (HRTEC) dizajniran je kako bi se pronašli odgovori na još uvijek neodgovorena pitanja vezana za razvoj jednog od najvažnijih prapovijesnih razdoblja. Jedan od osnovnih ciljeva projekta HRTEC je uspostava snažne apsolutne kronološke osnove uz pomoć AMS datiranja na velikom broju „short-life“ uzoraka te modeliranjem matematičkim algoritmima kao što je „Bayesian modeling“. Daljnji cilj jest upotreba relativno širokog spektra interdisciplinarnih metoda za prikupljanje i obradu različito znanstvenih skupova podataka za izradu snažnijih, pouzdanijih te manje plastičnih arheoloških interpretacija. Fokus istraživanja biti će područje istočne Hrvatske sa specifičnim, kronološki osjetljivim nalazištima kao što su tel naselja.  Jedno od uobičajenih svojstava telova jugoistočne Europe jest činjenica da su bili spaljeni (konkretno Bapska i Bogdanovci). Snažno gorenje arhitekture, keramike, biljaka i ostalih materijalnih elementa svakodnevnog života omogućilo je u visokom postotku očuvanje kulturnih slojeva što predstavlja idealan okoliš za navedena interdisciplinarna istraživanja.  ]]></summary_hr><summary_en><![CDATA[Project Houses, Roads & Traders of the Early European Civilization (HRTEC) is designed to give answers to still unanswered principal questions related to development one of the most important Prehistoric era.  One of the main goals of HRTEC is to establish a firm absolute chronological base of the Late Neolithic using AMS dating performed on high amount of short-life samples and modeled with widely used mathematical algorithms such is Bayesian modeling. Second target to pursue is with the use of relatively wide range interdisciplinary methods to collect and process different sciences data sets and use them to make archaeological interpretation more firm, reliable and three dimensional. High-accumulative communities, at the dawn of human manipulation with metal ores, went through dynamic changes in relatively short period of time. Interpretation of life within frames of mentioned short periods will be our main goal.]]></summary_en></project><project>
<id>3439</id><title_hr><![CDATA[Poticanje inovativnog ponašanja zaposlenika u javnom sektoru primjenom intervencija u dizajnu posla]]></title_hr><title_en><![CDATA[Fostering innovative work behaviour of public employees by using work design interventions]]></title_en><user_id>5575</user_id><user_firstLast_name>Tomislav Hernaus</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2014-09</proposal_call><code>UIP-2014-09-3909</code><acronim><![CDATA[INPUBWORK]]></acronim><duration>01.06.2015 - 30.09.2018</duration><status>Završio</status><financ_value>21.210,43 eur</financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Ekonomija, Psihologija, </scie_field_hr><scie_field_en>Economy, Psychology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Ekonomski fakultet u Zagrebu]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Economics and Business]]></institution_en><team_members_id>7317, 13145, 12896, 6198, 6242, 22840, </team_members_id><team_members_names><![CDATA[Nina Pološki Vokić, Miha Skerlavaj, Matej Černe, Ana Aleksić, Maja  Tadić, Matija Marić, ]]></team_members_names><keywords_hr><![CDATA[dizajn posla, inovativno ponašanje zaposlenika, intervencije posla, javna poduzeća, longitudinalno istraživanje, kvazi-eksperimenti, tjedni dnevnici]]></keywords_hr><keywords_en><![CDATA[work design, innovative work behaviour, job interventions, state-owned enterprises, longitudinal research, quasi-experiments, weekly diary study]]></keywords_en><summary_hr><![CDATA[Optimalno korištenje inovacijskog potencijala zaposlenika predstavlja glavni izazov upravljanja ljudskim potencijalima u današnjem globalnom i hiperkonkurentnom poslovnom okruženju. Nedavna istraživanja potvrdila su ulogu karakteristika posla kao ključnog prethodnika i usmjeravajućeg elementa za poticanje inovativnog ponašanja zaposlenika. Ipak, još uvijek ne znamo kako se različite karakteristike posla mijenjaju tijekom vremena, kakav je njihov međusobni odnos, koje su karakteristike najvažnije te kako ih je moguće uspješno mijenjati.Inovativno ponašanje zaposlenika posebice je važno i nedovoljno istraženo u javnim poduzećima. Nažalost, njihovi zaposlenici u velikoj mjeri su demotivirani i neproduktivni, dok su njihove organizacije neefikasne i nekonkurentne. Takvi negativni stavovi i loše radne prakse ograničavaju inovativno ponašanje i pružaju neadekvatne poslovne rezultate. Slijedom toga, svrha projekta je istražiti što potiče inovacije na razini posla. Planiramo provesti dubinsko istraživanje prakse dizajna posla u Republici Hrvatskoj. Analizirat ćemo karakteristike zadataka, socijalne i kognitivne aspekte poslova unutar četiri javna poduzeća od posebnog državnog značaja.Prilagođene intervencije posla (menadžerski, idiosinkratski dogovori, dorađivanje posla) bit će provedene u stvarnom radnom okruženju, zajedno s trofaznim longitudinalnim istraživanjem putem dnevnika i kvazi-eksperimentalnim nacrtom istraživanja. Pomoću intervencija u dizajnu posla, određene karakteristike posla bit će prilagođene i usklađene s osobnim i pozicijskim karakteristikama zaposlenika. Ostvarivanjem sklada između osobe i posla, potaknut će se inovativno ponašanje javnih zaposlenika, a time će se neizravno povećati i organizacijska inovativnost. Točnije, participativno akcijsko istraživanje osigurat će višu razinu generiranja ideja te dovesti do češćih procesnih unapređenja u promatranim javnim poduzećima, s mogućim učinkom prelijevanja i na druga javna poduzeća, a na dobrobit cjelokupnog hrvatskog gospodarstva.]]></summary_hr><summary_en><![CDATA[Optimally utilizing the innovative potential of employees has become a major human resource challenge within the global and highly competitive business environment. Recent studies have confirmed job characteristics as a critical antecedent and a driving force for innovative work behaviour. However, we still know little about how work design factors change over time, how they interact, which are the most important, and how they can be successfully changed.Innovative work behaviour is especially needed and understudied within state-owned enterprises. Their employees are largely unmotivated and unproductive, and organisations are ineffective and non-competitive. Such negative work attitudes and practices hinder innovative work behaviour and result in non-adequate business results. Therefore, the main purpose of the project is to explore the idea of what enhances innovation at the work level. We plan to carry out an in-depth research on work design in Croatia. We will analyse task-, social- and cognitive aspects of jobs within four strategically important state-owned enterprises. Tailored job interventions (e.g., managerial, I-deals, job crafting) will be used in a real life work setting, supplemented with three-way longitudinal diary study and quasi-experimental research design. Through work design interventions, particular set of job characteristics will be modified and aligned with personal- and job-related differences. By achieving a person-job fit, we will be able to foster innovative work behaviour of public employees, and thereby indirectly increase the level of organisational innovativeness. Specifically, the participatory action research applied will provide increased level of idea generation and will result in more frequent process improvements within sampled state-owned enterprises, with a potential spillover effect on other SOEs and significant benefits for the Croatian economy as a whole.]]></summary_en></project><project>
<id>3442</id><title_hr><![CDATA[Razvoj materijala za 3D tiskanje mikroreaktora]]></title_hr><title_en><![CDATA[Development of materials for 3D printing of microreactors]]></title_en><user_id>5338</user_id><user_firstLast_name>Domagoj Vrsaljko</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2014-09</proposal_call><code>UIP-2014-09-3154</code><acronim><![CDATA[3Dmicroreactors]]></acronim><duration>01.07.2015 - 30.06.2018</duration><status>Završio</status><financ_value>90.250,18 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Kemijsko inženjerstvo, </scie_field_hr><scie_field_en>Chemical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet kemijskog inženjerstva i tehnologije]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Chemical Engineering and Technology]]></institution_en><team_members_id>4425, 1529, </team_members_id><team_members_names><![CDATA[Krunoslav Žižek, Ivana Grčić, ]]></team_members_names><keywords_hr><![CDATA[mikroreaktori, 3D tisak, kompoziti, katalitički materijali, polimerne mješavine]]></keywords_hr><keywords_en><![CDATA[microreactors, 3D printing, kompoziti, catalytic materials, polymer blends]]></keywords_en><summary_hr><![CDATA[Tehnologija 3D tiska je relativno jeftin, automatiziran, i prilagodljiv način koji omogućuje laboratorijima i malim poduzećima pristup kemijsko-inženjerskim alatima, poput onih u velikim industrijskim okruženjima. 3D tiskanje se sastoji od izrade trodimenzionalnih fizičkih objekata iz digitalnih modela. 3D pisač koristi virtualni dizajn izrađen računalnim programom (CAD) i reproducira sloj-po-sloj do konačnog  objekta. Značajna prednost ove tehnike je u tome  što se konstrukcija objekta može jednostavno kontrolirati. Cilj projekta 3Dmicroreactors je istraživanje i razvoj polimernih kompozitnih materijala za upotrebu u 3D tiskanju mili- i mikroreaktora složene strukture. Članovi 3Dmicroreactors projektnog tima dolaze sa 4 različita zavoda kao stručnjaci u različitim područjima znanosti o materijalima i kemijskog inženjerstva, što jamči multidisciplinarnost i interdisciplinarnost projekta. U projektu 3Dmicroreactors ćemo pomoću polimernih kompozitnih materijala izraditi mikroreaktore s velikom preciznošću, uključujući složenu geometriju i zamršene unutarnje strukture, kao što su kanali s jasno definiranim dimenzijama . Nadalje, integracija senzora i katalizatora u građevnom materijalu, te razumijevanje odnosa svojstava materijala/katalizatora i kinetike procesa omogućit će projektiranje opreme, dopuštajući nam kombinaciju novih materijala i reakcijskih mehanizama  u inovativnom dizajnu reaktora. Budući da proces proizvodnje potrebnih dijelova traje kratko, jedan od rezultata projekta bit će i jeftina procedura za izradu protočnih uređaja. Tehnologija 3D tiska omogućit će kemijskim inženjerima jednostavan dizajn i osmišljavanje vlastitih reaktorskih sustava pritiskom na nekoliko tipki, nasuprot dosadašnjoj proizvodnji specijaliziranih reaktora od stakla.]]></summary_hr><summary_en><![CDATA[3D printing technology is a relatively cheap, automated, and customizable method that will make possible for synthetic laboratories and small companies to access chemical engineering tools typically used only in large-scale industrial settings. 3D printing consists of the fabrication of three-dimensional physical objects from a digital model. The 3D printer takes the virtual design from computer-aided design (CAD) software and reproduces it layer-by-layer until the physical definition of the layers gives the designed object. The significant advantage of this technique is that the architecture can be concisely controlled. Aim of the 3Dmicroreactors project is research and development of polymeric composite materials for use in 3D printing of intricate milli- and microreactors. The 3Dmicroreactors project team members come from 4 different departments and are specialists in different parts of materials and chemical engineering, guaranteeing multidisciplinarity and interdisciplinarity of the project.In the 3Dmicroreactors project we will, by using polymeric composite materials, build microreactors with high precision, including complex geometries and intricate internal structures - such as channels with well-defined size dimensions. Furthermore, integration of sensors and catalysts in the construction material, and understanding material properties and kinetics of the processes will enable the designing of the reactionware, allowing us to combine additional materials and kinetic knowledge with reactor designs. The additive manufacturing process of the devices takes a short time and will result in a cheap procedure for the fabrication of fluidic devices.3D printing technology will enable chemical engineers to design and fabricate their own inexpensive reaction vessels with the push of a few buttons opposing to paying experts for production of intricate glassware and specialized reactors.]]></summary_en></project><project>
<id>3451</id><title_hr><![CDATA[Glikozilacija plazmatskih proteina u razumijevanju dijabetesa tipa 1]]></title_hr><title_en><![CDATA[Human plasma glycome in comprehension of type 1 diabetes]]></title_en><user_id>11174</user_id><user_firstLast_name>Olga Gornik</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2014-09</proposal_call><code>UIP-2014-09-7769</code><acronim><![CDATA[GLYCO-T1D]]></acronim><duration>01.09.2015 - 31.12.2018</duration><status>Završio</status><financ_value>128.323,05 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Farmacija, Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Pharmaceutical sciences, Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Farmaceutsko-biokemijski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Pharmacy and Biochemistry]]></institution_en><team_members_id>5428, 5021, 13573, 5952, 5164, </team_members_id><team_members_names><![CDATA[Genadij Razdorov, Iva Mucalo, Tamara  Pavić, Toma Keser, Dario Rahelic, ]]></team_members_names><keywords_hr><![CDATA[glikozilacija, dijabetes tipa 1, glikom, genom, predispozicija]]></keywords_hr><keywords_en><![CDATA[glycosylation, type 1 diabetes, gycome, genome, predisposition]]></keywords_en><summary_hr><![CDATA[Glikozilacija je važna posttranslacijska modifikacija proteina koja često ima utjecaj na funkciju proteina. Proces glikozilacije je izrazito složen i reguliran mrežom gena koji su pokazali povezanost i s različitim bolestima. Glikani predstavljaju dobre potencijalne dijagnostičke alatke te doprinose razumijevanju etiologije mnogih bolesti. Značaj glikozilacije u dijabetesu tipa 1 (T1D) do sada nije istražen.T1D je oblik dijabetesa koji se javlja zbog autoimunog uništavanja stanica koje proizvode inzulin. Nedostatak brige za ove pacijente može biti letalan, stoga svako novo saznanje o ovoj bolesti predstavlja značajan doprinos. Povezivanje promjena u glikomu s genotipovima moglo bi rezultirati važnim rezultatima te potencijalno svrstati osobe u skupine bazirano na njihovim glikanskim i genomskim osobinama. Ova informacija bi se također mogla upotrijebiti za predviđanje rizika za razvoj bolesti kod pojedinca. Stoga ćemo u ovom istraživanju spojiti naša iskustva u genetičkim analizama i analitici glikana kako bismo identificirali glikanske promjene specifične za T1D za koje možemo kolerirati glikom i genom.Kako bi ostvarili cilj ovog istraživanja, analizirat ćemo glikane plazme obitelji s barem dvoje bolesnih potomaka te također zdravim potomcima. Uslijed ovisnosti glikana o godinama, roditelji neće biti uključeni u ovu studiju, pa će se tako analizirati preko 4500 dostupnih uzoraka. Za sve sudionike postoje rezultati genotipizacije.Glikani će se analizirati visokoprotočnom MALDI-TOF MS tehnologijom koja pruža pouzdanu analizu glikoma te je trenutno najsuvremenija glikoanalitička metoda.Uslijed neupitne uloge glikana u patološkim stanjima, izuzetno dobro definirane populacije izabrane za ovo istraživanje te upotrebu suvremene i osjetljive tehnologije, ovo istraživanje rezultirat će novim znanjima koja će unaprijediti razumijevanje i dijagnostiku dijabetesa tipa 1.]]></summary_hr><summary_en><![CDATA[Glycosylation is a posttranslational modification that provides great proteomic diversity and often impact protein function. This process is regulated by a network of genes, many of which show pleiotropy with different diseases. Glycans present a great potential diagnostic tool as well as contribute to the understanding of the aetiology of diseases. The importance of glycosylation in type 1 diabetes mellitus (T1D) has not been addressed by now. T1D is a form of diabetes that results from the autoimmune destruction of the insulin-producing beta cells in the pancreas. Lack of care for these patients can be lethal, so any new knowledge about the development of this disease would represent an important contribution. Integrating glycomic changes with the subjects’ known genotypes could generate powerful and important results, potentially defining groups based on their glycome and genomic characteristics. This information may also be used to predict an unaffected individual’s risk of disease. This is why, in this study, we will combine expertise in genetic analysis and analyses of plasma glycome in order to search for the glycomic changes that are specific to T1D and for which we can correlate glycome and genome.To reach the goals of this study, we will analyze plasma glycomes of families with both diabetic siblings and unaffected siblings. Due to the age-related changes in glycosylation, parents will not be included in this study, so over 4500 samples will be analysed. All these samples have their genotyping performed.Glycomes will be analysed using MALDI-TOF-MS technology, which provides reliable analysis and presents the best available glycoanalytic tool.Thus, due to the undeniable role of glycans in pathological conditions, the well characterized population selected for this study and the use of highly modern and sensitive technology, this study will result in important new insights that will advance the comprehension and management of type 1 diabetes mellitus.]]></summary_en></project><project>
<id>3452</id><title_hr><![CDATA[Vizualiziranje nacionalnog. Bratovštine i kolegiji Schiavona/Illira u Italiji i razmjena umjetničkih iskustava s jugoistočnom Europom (15. - 18. st.)]]></title_hr><title_en><![CDATA[Visualizing Nationhood: the Schiavoni/Illyrian Confraternities and Colleges in Italy and the Artistic Exchange with South East Europe (15th - 18th c.)]]></title_en><user_id>5486</user_id><user_firstLast_name>Jasenka Gudelj</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2014-09</proposal_call><code>IP-2014-09-2305</code><acronim><![CDATA[VisNat]]></acronim><duration>01.07.2015 - 30.06.2018</duration><status>Završio</status><financ_value>55.863,03 eur</financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Povijest umjetnosti, Povijest, Religijske znanosti, </scie_field_hr><scie_field_en>Art history, History, Religion, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Filozofski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Humanities and Social Sciences]]></institution_en><team_members_id>764, 3408, 13417, 762, 13442, 13527, </team_members_id><team_members_names><![CDATA[Danko Šourek, Daniel Premerl, Giuseppe Capriotti, Tanja Trška, Anita Ruso, Francesca Coltrinari, ]]></team_members_names><keywords_hr><![CDATA[Schiavoni/Illiri, bratovštine, kolegij, Rim, Venecija, Bologna, Marche, umjetnost]]></keywords_hr><keywords_en><![CDATA[Schiavoni/Illyrians, confraternity, college, Rome, Venice, Bologna, Marche, art]]></keywords_en><summary_hr><![CDATA[    Prve poznate organizirane skupine imigranata pristiglih iz povijesnih hrvatskih zemalja koji su dijelili isti jezik i istu katoličku vjeru spominju se u Italiji od 15. stoljeća, a okupljale su ih nacionalne bratovštine u Rimu, Veneciji, Recanatiju, Fanu, Loretu i Udinama, dok su institucionalnu potporu studentima talijanskih sveučilišta istoga podrijetla osiguravali kolegiji u Bolonji, Loretu i Fermu.Arhitektonske značajke građevina kojima su se koristile ove ustanove, kao i slikarska i kiparska djela koja su naručivali njihovi članovi, igrali su važnu ulogu u stvaranju kulturnoga identiteta ovih nacionalnih zajednica. Namjera je projekta proučiti konstruiranje svojstvenih kulturnih identiteta izraženih kroz umjetnička djela i arhitekturu institucija Schiavona/Ilira od 15. do 18. stoljeća, kroz istraživanje povijesnih naracija artikuliranih u vizualnom obliku. Ova će povijesno-umjetnički fenomeni biti promatrani u komparativnome svjetlu odnosno u kontekstu sličnih izričaja “nacionalnih” zajednica stranaca u Italiji. Osim pomne povijesno-umjetničke analize postojećih i dokumentiranih djela vizualnih umjetnosti navedenih nacionalnih institucija u Italiji, posebna će pažnja biti posvećena dinamici narudžbi umjetničkih djela od talijanskih umjetnika za regiju u kojoj se nalazi današnja Hrvatska, upravo kroz mrežu osobnih odnosa članova bratovština i alumna kolegija. Ovo će istraživanje pružiti nove spoznaje o kruženju ukusa i znanja kao i o utjecaju različitih talijanskih umjetničkih tržišta na situaciju u jugoistočnoj Europi, posebno na području današnje Hrvatske, obogaćujući pritom razumijevanje umjetničke baštine u konstrukciji proto-nacionalnih identiteta u europskom kontekstu.]]></summary_hr><summary_en><![CDATA[  The first known organized groups of people originating from historic Croatian lands sharing a common language and Catholic faith are mentioned in Italy from the 15th century. They congregated in the “Schiavoni/Illyrian” confraternities in Rome, Venice, Recanati, Fano, Loreto and Udine, while institutionalized assistance for students of the same origin attending Italian universities during the Early Modern period was provided by the “national” colleges in Bologna, Loreto and Fermo. The architecture of buildings used by these institutions, as well as paintings and sculpture and other works of art commissioned by their members, played an important role in the construction of the cultural identity of these immigrant communities. The aim of the project is to investigate the construction of intrinsic cultural identities that found their expression in the art and architecture of Schiavoni/Illyrian institutions over the centuries, through the exploration of historical narratives articulated in terms of visual arts. These art-historical phenomena are to be regarded in comparative perspective as well as in context of similar expressions found in “national” institutions of other foreign communities in Italy.In addition to in-depth art-historical analysis of the surviving and/or documented art and architecture of the said national institutions in Italy, special attention will be placed on the dynamics of artistic commissions, along with the issue of confraternity members or college alumni as possible mediators in Croatian patrons’ commissions from Italian artists. This research will provide a new insight on the circulation of taste and knowledge as well as on the impact of different Italian art markets on the art in the South-East Europe, particularly in the present-day Croatia, enriching the understanding of the role of artistic heritage in the construction of proto-national identity in the European context.]]></summary_en></project><project>
<id>3456</id><title_hr><![CDATA[Aromatski hidrazoni: sinteza, strukturna analiza, biološka aktivnost i analitička primjena]]></title_hr><title_en><![CDATA[Aromatic hydrazones: synthesis, structural analysis, biological activity and analytical application]]></title_en><user_id>851</user_id><user_firstLast_name>Nives Galić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2014-09</proposal_call><code>IP-2014-09-4841</code><acronim><![CDATA[ARHYD]]></acronim><duration>04.01.2016 - 03.01.2019</duration><status>Završio</status><financ_value>79.633,69 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, </scie_field_hr><scie_field_en>Chemistry, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>2809, 1457, 4752, 3061, 1237, 184, 5113, 1175, 5072, 1204, 1360, 19814, </team_members_id><team_members_names><![CDATA[Snežana Miljanić, Vasile Chis, Ivan Kosalec, Ana Budimir, Nevenka Poje, Darko Kontrec, Martina Rožmarić Mačefat, Adriana Kenđel, Matea Krmpotić, Tomislav Benković, Astrid Gojmerac Ivšić, Marijana Pocrnić, ]]></team_members_names><keywords_hr><![CDATA[Hidrazoni, kompleksi, struktura, kemija otopina, ekstrakcija, radiometrija, MS, NMR, UV-Vis, fluorescencija, IR, Raman, teorijsko istraživanje]]></keywords_hr><keywords_en><![CDATA[Hydrazones, complexes, structure, solution chemistry, extraction, radiometry, MS, NMR, UV-Vis, fluorescence, IR, Raman, theoretical study]]></keywords_en><summary_hr><![CDATA[Glavni cilj ovog projekta je razvoj novih metoda određivanja iona metala, kao i novih ekstrakcijsko-kromatografskih materijala za odjeljivanje nekih važnih radionuklida. Aktivne komponente u takvim sustavima bit će derivati aromatskih hidrazona koji će se pripraviti kondenzacijskim reakcijama hidrazida i različito supstituiranih aldehida ili ketona.Budući da različiti tautomerni i izomerni oblici hidrazona mogu imati i različita svojstva vezanja metala, za uspješnu primjenu ovih spojeva neophodno je detaljno proučiti navedene ravnoteže, što će se i provesti u okviru ovog projekta. Odredit će se konstante protoniranja i kinetika hidrolize u smjesama otapala s vodom. Za strukturnu karakterizaciju liganada u otopini koristit će se spektrometrija masa, tekućinska kromatografija i različite spektroskopske tehnike (NMR, UV-Vis, fluorescencija, IR i Ramanova spektroskopija). Također će se provesti i teorijska istraživanja.U otopini će se istražiti reakcije kompleksiranja hidrazona i odabranih iona metala i radionuklida. Gdjegod će to biti moguće, odredit će se konstante stabilnosti i izolirati kompleksni spojevi u čvrstom stanju. Na temelju dobivenih rezultata razvit će se spektrofotometrijske i/ili spektrofluorimetrijske metode određivanja iona metala. Selektivnost predloženih metoda poboljšat će se uvođenjem ekstrakcije tekuće-tekuće pri čemu će se proučiti utjecaj površinski aktivnih tvari na djelotvornost postupka. Nadalje, istražit će se sposobnost hidrazona kao ekstrakcijsko-kromatografskih smola za odjeljivanje radionuklida.U okviru projekta također će se odrediti biološka aktivnost pripravljenih hidrazona i njihovih kompleksnih spojeva prema odabranim bakterijskim i gljivičnim vrstama.Na kraju će se korelirati struktura hidrazona s njihovim fizičko-kemijskim svojstvima, što je od osobitog značaja za njihovu uspješnu primjenu kao biološki aktivnih spojeva ili analitičkih reagensa. ]]></summary_hr><summary_en><![CDATA[The main goal of the project is to develop new methods for metal ions determination as well as new extraction chromatographic materials for separations of some important radionuclides. The active components in such systems will be aromatic hydrazone derivatives. They will be synthesized by condensation reactions of hydrazide and differently substituted aldehydes or ketones.Since different tautomeric and isomeric forms of hydrazones can have diverse chelating properties, the detailed study of the corresponding equilibria is important for successful application of these compounds and will be performed within the project. Protonation properties and kinetics of hydrolysis of hydrazones in solvents containing water will be examined. For structural characterization of ligands in solution mass spectrometry, liquid chromatography, and different spectroscopic techniques (NMR, UV-Vis, fluorescence, IR and Raman spectroscopy) will be used. The computational studies will be carried out as well.The complexation reactions of hydrazones with selected metal ions and radionuclides will be investigated in solution. Whenever possible, complex stability constants will be determined and solid complexes will be isolated. Based on the results obtained, spectrophotometric and/or spectrofluorimetric methods for metal ions determination will be developed. The selectivity of the proposed methods will be further improved using extraction procedure. The influence of surfactants on the extraction systems will be explored. Furthermore, hydrazones abilities as extraction chromatographic resins towards selected radionuclides will be investigated.Prepared hydrazones and their complexes will be screened for biological activity on selected microbial species and fungi.Finally, the correlation of the hydrazones structures and their physico-chemical properties will be proposed, which is of great importance for successful applications of such compounds as bioactive agents or analytical reagents.]]></summary_en></project><project>
<id>3458</id><title_hr><![CDATA[Uloga estrogen i androgen receptora u aktivaciji strome oralnog karcinoma i njihov utjecaj na peživljavanje bolesnika]]></title_hr><title_en><![CDATA[The role of estrogen and androgen receptors in active stroma of oral cancer and its influence on patients survival]]></title_en><user_id>12809</user_id><user_firstLast_name>Vanja  Vučićević Boras</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2014-09</proposal_call><code>IP-2014-09-6985</code><acronim><![CDATA[ACTIVSTROMORALCANCER]]></acronim><duration>01.10.2015 - 30.09.2019</duration><status>Prekinut</status><financ_value>46.452,98 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Kliničke medicinske znanosti, Javno zdravstvo i zdravstvena zaštita, </scie_field_hr><scie_field_en>Clinical sciences, Public health and health services, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Stomatološki fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Dentistry]]></institution_en><team_members_id>2654, 12334, 13606, 2696, 13614, 6833, 6702, 7482, </team_members_id><team_members_names><![CDATA[Aleksandra Fučić, Dragana Gabrić Pandurić, Antun Major, Zoran Rakušić, Vesna Bišof, Danko Velimir  Vrdoljak, Čedna Tomasović-Lončarić, Mihajlo Virag, ]]></team_members_names><keywords_hr><![CDATA[oralni karcinom, estrogen, androgen, citokini, stroma]]></keywords_hr><keywords_en><![CDATA[oral cancer, estrogen, androgen, cytokines, stroma]]></keywords_en><summary_hr><![CDATA[Učestalost oralnog karcinom pločastih stanica (OKPS) u Hrvatskoj je 8,4 osobe na 100.00 stanovnika. Najveća učestalost ovog karcinoma je u muškaraca iznad 50 godina starosti. Znakovito povećani rizik za razvoj oralnog karcinoma imaju pušači i osobe koje svakodnevno konzumiraju alkohol. OKPS je agresivni karcinom koji brzo metastazira (oko 50% oboljelih ima pri postavljanju dijagnoze metastaze u limfnim čvorovima) te je uspješna dijagnostika od velike važnosti za učinkovitu terapiju. Unatoč razvoju novih terapijskih pristupa u liječenju ovog karcinoma ne bilježi se značajni porast petogodišnjeg preživljavanja zadnjih desetljeća. Standardni oblici liječenja su kirurške disekcije uz liječenje zračenjem, a kemoterapija se rjeđe primjenjuje. Najnovija istraživanja ukazuju da je uz histološki nalaz OKPS od velikog značaja i procjena aktivnosti strome samog tumora koja može sadržavati stanice koje ispuštaju signalne molekule ključne za razvoj metastaza. Cilj ovog projekta je pridonijeti saznanjima o broju i aktivaciji stanica u stromi OKPS-a u odnosu na preživljavanje bolesnika. Istraživanje će se zasnivati na arhivskim bioptatima, a uključit će procjenu razine receptora na malignim stanicama i stanicama strome tumora (androgeni,estrogeni), metaloproteinaza 9, citokina(IL-1beta, IL-6), vaskularnog endotelnog čimbenika rasta i čimbenika hipoksije te čimbenika proliferacija Ki67. Očekivani rezultati pridonijet će poboljšanju informativnosti histološkog nalaza i individualnom pristupu liječenja OKPS-a. Putem upitnika ispitati će se životne navike bolesnika, izloženost te obiteljska anamneza i njihov mogući utjecaj na histološki profil OKPS-a. U okviru projekta izradit će se web stranica sa rezultatima projekta, bazom tekućih istraživačkih projekata, kliničkih studija, relevantni publikacija i forumom. Web stranica će pridonijeti boljoj suradnji kliničara i drugih zainteresiranih eksperata, a u svrhu boljitka za bolesnike kao i budućoj međunarodnoj prepoznatljivosti. ]]></summary_hr><summary_en><![CDATA[The incidence of oral squamous cell carcinoma (OSCC) in Croatia is 8.4 persons per 100.00 inhabitants. The highest incidence of cancer is in men over 50 years of age. Significantly increased risk of developing OSCC is among smokers and people who daily consume alcohol. OSCC is an aggressive cancer that metastasizes (about 50% of patients have at diagnosis lymph node metastases) thus the successful diagnosis is of major importance for effective therapy. Despite the development of new therapeutics in the treatment of OSCC, no significant increase in five-year survival has been recorded in the past decade. Standard algorithms of treatment include surgical dissection with radiotherapy, while chemotherapy is rarely applied. The latest research suggests that in OSCC is of great importance the evaluation of tumor stroma activation, as it may contain cells that produce signaling molecules crucial for the development of metastases. The aim of this project is to obtain insight into activated cells in the stroma of OSCC in relation to patient survival. The study will be based on archived tissues, and will involve assessing the level of receptor on malignant cells and stromal tumors (androgens, estrogens), metaloproteinase 9, cytokines (IL-1 beta, IL-6), vascular endothelial growth factor, hypoxia factors and factors Ki67 proliferation. The expected result will contribute to histological diagnostics and enable individual approach of OSCC therapy. Through questionnaires will be examined the lifestyle habits of patients, exposures, family history and their possible impact on the OSCC histological profile. Within the project a website will be developed which will contain results of the project, the base of current research projects, clinical studies, relevant publications and a forum. The website will contribute to better cooperation between clinicians and other interested experts, and bring benefit for patients as well as future international recognition]]></summary_en></project><project>
<id>3459</id><title_hr><![CDATA[Kanali i učinkovitost fiskalnih devalvacija]]></title_hr><title_en><![CDATA[Channels and effectiveness of fiscal devaluations]]></title_en><user_id>983</user_id><user_firstLast_name>Goran Vukšić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2014-09</proposal_call><code>IP-2014-09-7017</code><acronim><![CDATA[FIDE]]></acronim><duration>01.09.2015 - 31.08.2019</duration><status>Završio</status><financ_value>18.488,29 eur</financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Ekonomija, </scie_field_hr><scie_field_en>Economy, </scie_field_en><institution_hr><![CDATA[Institut za javne financije]]></institution_hr><institution_en><![CDATA[Institute of Public Finance]]></institution_en><team_members_id>13280, 606, 603, </team_members_id><team_members_names><![CDATA[Mario Holzner, Marina Tkalec, Maruška Vizek, ]]></team_members_names><keywords_hr><![CDATA[fiskalna politika, izvoz, konkurentnost, oporezivanje, Europska Unija]]></keywords_hr><keywords_en><![CDATA[fiscal policy, exports, competitiveness, taxation, European Union]]></keywords_en><summary_hr><![CDATA[Fiskalna devalvacija može se opisati kao kombinacija fiskalnih politika s neutralnim učinkom na proračun, a koja bi trebala oponašati učinke devalvacije nominalnog valutnog tečaja, tj. poboljšati vanjsku konkurentnost zemlje i povećati neto izvoz. Nakon početka recentne ekonomske krize, fiskalne devalvacije postale su prioritetna tema u diskusijama ekonomske politike u Europi. Te diskusije se uglavnom odnose na zemlje članice Europske Monetarne Unije, ali je tema vrlo relevantna i za širi skup zemalja, uključujući one koje su možda izvan monetarnih unija, ali provode politiku fiksnog valutnog tečaja (npr. Hrvatska). Postoji, međutim, značajan jaz u znanstvenom istraživanju fiskalnih devalvacija. Najveći dio postojećih studija sastoji se od simulacijskih analiza čiji su rezultati određeni specifikacijama i kalibracijama modela. Ekonometrijske studije, s druge strane, koje bi mogle odgovoriti na pitanja o učinkovitosti i kanalima fiskalnih devalvacija u praksi i dalje su rijetke. Predloženo istraživanje namjerava popuniti neke od praznina u postojećoj literaturi pružajući nove ekonometrijske rezultate u unaprijeđenom ekonometrijskom pristupu testiranju hipoteze o učinkovitosti fiskalnih devalvacija, te istraživanjem relevantnosti nekih pojedinačnih kanala kroz koje bi fiskalna devalvacija trebala djelovati. Predloženo istraživanje podijeljeno je u četiri segmenta: 1) Testiranje učinkovitosti fiskalnih devalvacija u EU koristeći bilateralne trgovinske podatke; 2) Testiranje učinka fiskalne devalvacije na realne valutne tečajeve; 3) Testiranje postojanja razlika u učincima fiskalnih devalvacija za industrije s različitim intenzitetom rada u proizvodnji; 4) Testiranje učinka smanjenja doprinosa za socijalno osiguranje (i cjelokupnog poreznog opterećenja rada) na plaće. Naš uzorak uključuje sve zemlje EU za koje su dostupni podaci. Također ćemo uzeti u obzir razdoblje recentne krize tijekom koje su mnoge zemlje EU provele reforme poreznih sustava.]]></summary_hr><summary_en><![CDATA[Fiscal devaluation can be described as a budget-neutral mix of fiscal policies which should mimic the effects of nominal exchange rate devaluation, i.e. bring improvements in country’s external competitiveness and increase net exports. After the outset of the recent economic crisis, fiscal devaluations have become priority topic in economic policy discussions in Europe. These discussions are mostly related to European Monetary Union member states, but the topic is highly relevant for a broader set of countries, including those which may be outside currency unions, but pursue fixed exchange rate policy (e.g. Croatia). There are, however, significant gaps in the scientific research of fiscal devaluations. The largest part of related contributions consists of simulation studies, whose results are driven by model specifications and calibrations. The econometric studies, on the other hand, which could provide answers on the effectiveness and channels of fiscal devaluations in practice, remain very scarce. The proposed research aims to fill some of the gaps in the literature, by providing new econometric evidence in an improved econometric approach to testing the hypothesis of the fiscal devaluation effectiveness, and by examining the relevance of some of the specific channels through which fiscal devaluations should work. The proposed research is divided into four segments: 1) Testing the effectiveness of fiscal devaluations in the EU using bilateral trade data; 2) Testing the impact of fiscal devaluation on real exchange rates; 3) Testing whether the effects of fiscal devaluations vary for industries with different labor intensity in production; 4) Testing the impact of cuts in social security contributions (and overall tax burden on labor) on wages. Our sample will include all EU countries for which data is available. We shall also consider the period of the recent crisis during which many EU countries implemented reforms of taxation systems. ]]></summary_en></project><project>
<id>3460</id><title_hr><![CDATA[Uspostava dugoročnog znanstvenog monitoringa prirodnih šumskih ekosustava u Hrvatskoj]]></title_hr><title_en><![CDATA[Establishing Long-Term Scientific Monitoring of Natural Forest Ecosystems in Croatia]]></title_en><user_id>3754</user_id><user_firstLast_name>Stjepan Mikac</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2014-09</proposal_call><code>IP-2014-09-1834</code><acronim><![CDATA[CroFEM]]></acronim><duration>01.09.2015 - 31.08.2018</duration><status>Završio</status><financ_value>86.488,82 eur</financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Šumarstvo, Biotehnologija, </scie_field_hr><scie_field_en>Forestry, Biotechnology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet šumarstva i drvne tehnologije]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Forestry and Wood Technology]]></institution_en><team_members_id>12598, 12604, 13634, 13518, 13679, 12394, 12615, 13592, 13587, 13583, 12737, 13572, 13636, 13672, 12981, 13529, 12827, 13542, 12710, 13749, 13764, 8749, 25182, </team_members_id><team_members_names><![CDATA[Irena Šapić, Joso Vukelić, Antun Alegro, Tomislav Levanič, Željko Španjol, Darko Bakšić, Damir Ugarković, Stanislav Kucbel, Peter Jaloviar, Miroslav Balanda, Mislav Vedriš, Ernest Goršić, Nera Bakšić (rođ. Marković), Milan Oršanić, HRVOJE BARAĆ, Dušan Roženbergar, Vinko Paulić, Thomas Andrew Nagel, Damir Drvodelić, Jurij Diaci, Hubert Hasenauer, Mario Šango, Ljubica Lukač, ]]></team_members_names><keywords_hr><![CDATA[ekstenzivni monitoring, intenzivni monitoring, prašume, dinamike prašuma, dugoročna promjene]]></keywords_hr><keywords_en><![CDATA[extensive monitoring, intensive, old-growth forest, forest dynamic, long-term changes]]></keywords_en><summary_hr><![CDATA[Hrvatska, u usporedbi s većinom Srednjoeuropskih zemalja, ima razmjerno prirodne šumske sa brojnim visoko vrijednim lokalitetima koji posjeduju karakter izvornih prašuma. Ideja o sustavnom multidisciplinarnom ekološkom monitoringu u Hrvatskoj pojavila se 1965. godine, no nije uspješno realizirana. Na osnovi te ideje, te potaknuto povećanjem sveukupnog interesa za praćenje promjena i dinamike prirodnih ekosustava, početkom 80-tih godina osnovane su trajne plohe po načelima UNESCO-vog programa MAB (Man and the Biosphere Programme). Nadahnuti potrebom za boljim razumijevanjem prirodne dinamike šumskih ekosustava i dugoročnim praćenjem promjena predlažemo ovaj projekt sa ciljem uspostave dugoročnog znanstvenog monitoringa, uz revitalizaciju postojećih i osnivanje novih ploha, čime će se stvoriti mreža terenskih laboratorija na kojima će sadašnji i budući znanstvenici nadograđivati svoje znanstvene kapacitete. Projektom se žele objediniti znanja i uspostaviti interdisciplinarna dugoročna istraživanja s jednim zajedničkim ciljem – razumijevanjei praćenje dinamike šumskih ekosustava. Projekt je zamišljen na dvije razine intenziteta monitoringa: 1) ekstenzivni monitoring-EM (I) i 2) intenzivni monitoring-IM (II). Ekstenzivni monitoring rezultirao bi sa 50-60 pokusnih objekata diljem Hrvatske dok bi se intenzivnim monitoringom obuhvatilo 5 najreprezentativnijih prašumskih objekata. IM treba poslužiti kao reprezentativni objekt istraživanja za sve plohe ekstenzivnoga monitoringa, dok EM omogućava procjenu u kojoj se mjeri rezultat intenzivnog monitoringa slučaja mogu generalizirati za jednaki stanišni tip, geološku podlogu, vegetacijska obilježja i slično sa relativno brzom i jeftinom izmjerom indikatora, koji pokazuju stanje ekosustava.]]></summary_hr><summary_en><![CDATA[Croatia, in comparison with most Central European countries, has a valuable forest areas with characteristics of a old-growth forest. The idea of systematic multidisciplinary, environmental monitoring in Croatia appeared in 1965. Based on these ideas, and driven by the growing interest in monitoring changes and dynamics of natural ecosystems, in early 80s the long-term, permanent monitoring plots  were established according to the principles of the UNESCO MAB program. Unfortunately, after the initial establishment, these plots were not systematically monitored. Inspired by the need for better understanding of the natural dynamics of forest ecosystems and the long-term monitoring we propose this project with the aim of establishing a long-term scientific monitoring. It  includes revitalization of existing and establishment of new monitoring plots which will,  in the end, represent a network of field laboratories where current and future researchers would build their research capacities. The project aims to consolidate knowledge and establish a long-term interdisciplinary research with one common goal – understanding and  monitoring the dynamics of forest ecosystems. The project is designed on two levels of intensity: 1) extensive monitoring-EM (I) and 2) intensive monitoring-IM (II). EM would result in the 50-60 plots across the Croatia while five of the most representative old-growth forest sites  will be the object of IM. IM should serve as a representative object of research for all plots of an EM, while EM enables the estimation of the  extent to which the results of the IM case study can be generalized for the habitat type, the geological substrate, vegetation characteristics and the like. This  by using relatively quick and inexpensive survey indicators, which show the status of ecosystem. ]]></summary_en></project><project>
<id>3462</id><title_hr><![CDATA[Zvijezde i prašina: struktura, sastav i interakcija]]></title_hr><title_en><![CDATA[Stars and dust: structure, composition and interaction]]></title_en><user_id>7697</user_id><user_firstLast_name>Krešimir  Pavlovski</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2014-09</proposal_call><code>IP-2014-09-8656</code><acronim><![CDATA[STARDUST]]></acronim><duration>01.05.2015 - 30.04.2019</duration><status>Završio</status><financ_value>126.235,32 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, </scie_field_hr><scie_field_en>Physics, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>12397, 11189, 13362, 13561, 13458, 13368, 12828, 22567, </team_members_id><team_members_names><![CDATA[Goranka Bilalbegović, Dubravka Kotnik-Karuza, Ettore  Tamajo, Dejan Vinković, Petar Mimica, Miljenko Čemeljić, Tomislav Jurkić, Ahmet Dervisoglu, ]]></team_members_names><keywords_hr><![CDATA[zvijezde, dvojne zvijezde, zvjezdana evolucija, akrecijski diskovi, protoplanetarni diskovi, spektroskopija]]></keywords_hr><keywords_en><![CDATA[stars, binary stars, stellar evolution, accretion disk, protoplanetary disk,  spectroscopy]]></keywords_en><summary_hr><![CDATA[Projekt se bavi zvijezdama i kozmičkom prašinom, važnim barionskim dijelom Svemira. Interakcija izmedu prašine, plina i zvijezda prisutna je kroz cijelu zvjezdanu i galaktičku  evoluciju, od nastanka zvijezda i planeta sve do konačne eksplozije supernova. U vremenu precizne kozmologije i potrage za životom na drugim svjetovima, zvjezdana astrofizika ponovno je ekstremno relevantna. Naveli smo brojne važne teme u različitim fazama zvjezdane evolucije  i interakcije zvijezda s njihovom cirkumstelarnom i interstelarnom okolinom. Naš je glavni cilj ispitivanje zvjezdanih evolucijskih modela. Pomoću naprednih metoda spektralnog raspetljavanja, koje smo pionirski koristili i unaprijedili, u stanju smo izmjeriti metalicitet zvijezda u dvojnim sustavima s velikom preciznosti i na taj način otkloniti glavnu prepreku u usporedbi empirijskih podataka s modelima. Planiramo na taj način analizirati istaknute dvojne zvijezde različitih masa kako bismo dali najstrože testove različitih zvjezdanih evolucijskih modela i baždarili učinkovitost rotacijskog miješanja, konvektivnog probijanja jezgre ili duljine miješanja tvari. Proračuni prijenosa zračenja u prašinastim omotačima i protoplanetarnim diskovima, uključujući i MHD proračune u graničnom području zvijezda-disk bit će provedeni s velikim prostornim razlučivanjem što omogućuje računalni program LELUYA kojeg je razvio jedan od nas. Ab initio DFT (funkcional gustoće) proračuni trebali bi omogućiti identifikaciju i sastav nanočestica u interstelarnoj prašini iz infracrvenih i rendgenskih spektara dobivenih opažanjima na svemirskim teleskopima. Ovo je prvi pokušaj u okupljanju raspršenih astrofizičkih istraživanja u Hrvatskoj u znantno fokusiranom smjeru. Istraživački je tim sastavljen od hrvatskih istraživača iz 6 hrvatskih i 2 strane institucije uključujući sva četiri  glavna hrvatska sveučilišta. Nadamo se da će to unaprijediti zajednička istraživanja i učiniti astrofizička istraživanja u zemlji puno koherentnijim i bolje organiziranim.]]></summary_hr><summary_en><![CDATA[This project deals with stars and cosmic dust, important baryonic constituents of the Universe.   The interplay between dust, gas and stars is present throughout stellar and Galactic evolution, from star and planet formation until ultimate final stages in supernovae explosions.    In the era of precision cosmology and of search for life on other worlds, stellar astrophysics has become extremely relevant. We address a number of important topics in the various stages of stellar evolution and interaction of stars with their circumstellar and interstellar environment. Our principal objective is probing stellar evolution models. With sophisticated methods of spectral disentangling we pioneered and upgraded we are able to measure metallicity of the stars in binaries with the high precision and breakdown the main obstacle in comparing empirical data to models. We plan to analyse benchmark binary stars along the mass sequence to provide the stringent tests of different stellar evolution models and parametrise efficiency of rotational mixing, convective core overshooting or mixing length.  Radiative transfer calculations in dusty envelopes and protoplanetary disks, including MHD calculations in boundary star-disk region would be performed with a high spatial resolution which  is enabled by the code LELUYA devolped by one of us. Ab initio quantum density functional theory calculations would enable identifications and composition of interstellar dust nanoparicles from IR and X-ray spectra obtained on-board space telescopes. This is is the first attempt to organise dispersed astrophysical research in Croatia into more focused direction. The research team is assembled with the Croatian scientist from 6 Croatian and 2 foreign institutions including all the four major Croatian universities. We hope this would promote collaborative research and make astrophysical research in the country more coherent and better organised.]]></summary_en></project><project>
<id>3464</id><title_hr><![CDATA[Razjašnjavanje sortne tipičnosti vina i maslinovih ulja od hrvatskih domaćih sorti]]></title_hr><title_en><![CDATA[Unravelling the varietal TYPIcity of wines and olive oils from CROatian native varieties]]></title_en><user_id>4924</user_id><user_firstLast_name>Igor Lukić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2014-09</proposal_call><code>UIP-2014-09-1194</code><acronim><![CDATA[TYPICRO]]></acronim><duration>01.07.2015 - 30.06.2018</duration><status>Završio</status><financ_value>75.422,41 eur</financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Poljoprivreda, Prehrambena tehnologija, </scie_field_hr><scie_field_en>Agriculture, Food technology, </scie_field_en><institution_hr><![CDATA[Institut za poljoprivredu i turizam]]></institution_hr><institution_en><![CDATA[Institute of Agriculture and Tourism in Poreč]]></institution_en><team_members_id>6511, 7005, 5679, 6369, 13450, 2790, 5191, 13660, 7171, 18945, 21020, </team_members_id><team_members_names><![CDATA[Sanja Radeka, Marijan Bubola, Karolina Brkić Bubola, Marin Krapac, Olivera Koprivnjak, Mirella Žanetić, Marina Lukić, Tomislav Plavša, Urska Vrhovsek, Sara Godena, Ivana Horvat, ]]></team_members_names><keywords_hr><![CDATA[sortna tipičnost, vino, maslinovo ulje, domaće sorte, Hrvatska, hlapljive arome, fenoli, senzorna analiza, kemometrija, tehnologija]]></keywords_hr><keywords_en><![CDATA[varietal typicity, wine, olive oil, native varieties, Croatia, volatile aroma, phenols, sensory evaluation, chemometrics, technology]]></keywords_en><summary_hr><![CDATA[Projekt TYPICRO nastoji razjasniti sortnu tipičnost vina i maslinovih ulja od hrvatskih domaćih sorti. Odabrati će se tipični uzorci te će se definirati tipične senzorne karakteristike i deskriptori od strane profesionalnih certificiranih senzornih ocjenjivača. Izraditi će se novi obrazac za kvantitativno deskriptivno senzorno ocjenjivanje tipičnosti. Uzorci tipičnih vina i maslinovih ulja od domaćih i introduciranih sorti biti će podvrgnuti detaljnom kemijskom profiliranju i kvantifikaciji pomoću mikroekstrakcije na čvrstoj fazi uz plinsku kromatografiju-spektrometriju masa (HS-SPME-GC-MS) za hlapljive spojeve arome, te tekućinske kromatografije visokog razlučivanja s detekcijom nizom dioda (HPLC-DAD) za fenole. Uzorci će se senzorno ocijeniti kvantitativnom deskriptivnom analizom. Rezultati će biti obrađeni kemometrijskim metodama. Prototipski proizvodi domaćih sorti biti će podvrgnuti dubinskoj metabolomskoj i olfaktometrijskoj (AEDA s GC-O) analizi u svrhu identifikacije novih spojeva, te određivanja hijerarhije hlapljivih sastojaka odnosno njihovog relativnog doprinosa tipičnoj aromi. Očekivani rezultati uključuju određivanje tipičnog kemijskog sastava i senzornih svojstava sortnih vina i maslinovih ulja od domaćih i introduciranih sorti, utvrđivanje fizikalno-kemijske osnove i nositelja senzorne tipičnosti, utvrđivanje biljega sortnog podrijetla za diferencijaciju između tipičnih proizvoda od domaćih i introduciranih sorti, određivanje nepromjenjivih osobina i pokazatelja sortnog podrijetla unatoč unutarsortnoj varijabilnosti, te određivanje unutarsortnih razlika. Kroz niz poljskih i tehnoloških pokusa identificirati će se čimbenici koji doprinose isticanju i očuvanju tipičnosti. Biti će ispitan stupanj prepoznatljivosti tipičnih domaćih vina i ulja među stručnjacima, znalcima i proizvođačima. Rezultati ovog projekta predstaviti će se kroz niz javnih predavanja, konferencija i radionica, te će biti objavljeni u međunarodno relevantnim znanstvenim časopisima.]]></summary_hr><summary_en><![CDATA[TYPICRO project aims to unravel the varietal typicity of wines and olive oils from Croatian native varieties. Typical wines and olive oils will be selected and their typical sensory characteristics and descriptors will be defined by professional certified tasters. A novel quantitative descriptive sensory evaluation form for the assessment of typicity will be created. Typical samples from native and introduced varieties will be subjected to chemical profiling and quantification by headspace solid-phase microextraction with gas chromatography-mass spectrometry (HS-SPME-GC-MS) for volatile aromas, and high performance liquid chromatography with diode-array detection (HPLC-DAD) for phenolics. Quantitative descriptive sensory evaluation will be performed. The results will be processed by chemometrics. The prototypical monovarietal products will be subjected to in-depth metabolomic and olfactometric analysis to identify previously unidentified compounds, and to determine the hierarchy of volatiles and their relative contribution to typical aroma. Expected results include: determination of typical chemical composition and sensory characteristics of wines and olive oils from native and introduced varieties in Croatia, determination of the physico-chemical basis and drivers of sensory typicity, determination of markers of varietal origin able to discriminate between typical products from native and introduced varieties, determination of unchanging characteristics and indicators that remain determinants of varietal origin despite intra-varietal variability, determination of intra-varietal differences. Factors that highlight and preserve varietal typicity will be identified through a set of field and technological experiments. The recognisability of typical products will be tested in blind-tasting trials. The outcomes of the project will be disseminated through public presentations, conferences and a workshop, and published in internationally relevant scientific journals.]]></summary_en></project><project>
<id>3466</id><title_hr><![CDATA[Kristalno inženjerstvo višekomponentnih metaloorganskih materijala povezanih halogenskom vezom: ususret supramolekulskom ugađanju strukture i svojstava]]></title_hr><title_en><![CDATA[Crystal engineering of multicomponent halogen bonded metal-organic materials: towards supramolecular control over structure and properties]]></title_en><user_id>356</user_id><user_firstLast_name>Dominik Cinčić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2014-09</proposal_call><code>IP-2014-09-7367</code><acronim><![CDATA[CrystEngMOM]]></acronim><duration>15.09.2015 - 14.09.2019</duration><status>Završio</status><financ_value>115.714,38 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, </scie_field_hr><scie_field_en>Chemistry, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>310, 4525, 708, 12541, 13224, 13225, 21344, 24307, 25023, 25323, </team_members_id><team_members_names><![CDATA[Vladimir Stilinović, Nenad Judaš, Zora Popović, Vinko Nemec, Tomislav Friscic, Robin Stein, Katarina Lisac, Nikola Bedeković, Matea Vitković, Luka Fotović, ]]></team_members_names><keywords_hr><![CDATA[Halogenska veza, metaloorganski materijali, kokristali, supramolekulska kemija, mehanosinteza]]></keywords_hr><keywords_en><![CDATA[Halogen bond, metal-organic materials, cocrystals, supramolecular chemistry, mechanosynthesis]]></keywords_en><summary_hr><![CDATA[Glavni cilj predloženog istraživanja je razvijanje općeg principa priprave višekomponentnih kristalnih materijala (kokristala) ugodivih svojstava koji sadrže metaloorganske jedinice povezane halogenskim vezama. Ciljana sinteza kokristala metaloorganskih spojeva s donorima halogenske veze predstavljala bi značajan doprinos ne samo kristalnom inženjerstvu već i kemiji materijala te supramolekulskoj kemiji krutina. Predloženo istraživanje otvorit će put ka sintezi novih supramolekulskih krutina kontrolirane strukture i dimenzionalnosti sastavljenih od metaloorganskih jedinica. Takvi materijali mogu imati magnetska, optička i električna svojstva različita od svojstava organskih supramolekulskih materijala. Uz temeljne spoznaje o povezivanju metaloorganskih spojeva halogenskim vezama, proučit će se mogućnost primjene takovog povezivanja u ciljanoj sintezi fotoosjetljivih materijala, navlast kokristala sposobnih prevoditi svjetlostnu energiju u mehaničku. Drugi dio predloženog projekta bit će dizajn i sinteza organskih višekomponentnih materijala povezanih halogenskim vezama. Do sada je izučavanje halogenskih veza bilo osjetno ograničeno jednoličnošću dostupnih donora halogenske veze. Predložena istraživačka skupina spaja iskustva pojedinih suradnika u kovalentnoj sintezi, koordinacijskoj kemiji te kristalnim inženjerstvu, što će omogućiti sintezu kako novih donora halogenske veze, tako i metaloorganskih akceptora te supramolekulskih krutina. Ti će spojevi omogućiti temeljno istraživanje sintonâ halogenske veze, te izučavanje pouzdanih načina izrade proširenih metaloorganskih materijala povezanih halogenskim vezama i mogućnosti priprave izostrukturnih metaloorganskih kokristala radi ugađanja svojstava materijala unošenjem samo malih promjena u zadanu arhitekturu kokristala.]]></summary_hr><summary_en><![CDATA[The principal aim of the proposed research is to develop the first general designs for the assembly of functional multicomponent crystalline materials (cocrystals) involving metal-organic units organized by way of halogen-bonding interactions. The controlled and deliberate synthesis of halogen-bonded cocrystals involving metal-organic building blocks remains an outstanding challenge of crystal engineering, materials science and solid-state supramolecular chemistry. The proposed research will open a path to synthesize new molecular materials with controlled 1-, 2- or 3-D architectures, involving metal-organic building blocks which are expected to provide access to new magnetic, optical and electrical properties not usually available in carbon-based supramolecular networks. In particular, besides establishing the fundamental aspects of the design of halogen-bonded metal-organic materials, the proposed research will explore the application of these designs in the synthesis of photoresponsive switching materials, specifically of cocrystals capable of transforming light into mechanical motion. Another element of the proposed research project will be the design and synthesis of purely organic halogen-bonded multi-component materials. The field of halogen-bonded cocrystals has so far been heavily limited by the poor availability of diverse halogen bond donor building blocks. A particular strength of the assembled research team lies in the extensive experience in covalent synthesis, coordination chemistry and crystal engineering, enabling the synthesis of new halogen bond donors of different bonding strength and directionality, which will be employed for the fundamental studies of halogen bonding synthons, of reliable strategies for the construction of extended halogen bonded metal-organic materials, and of isostructural metal-organic cocrystals as a means to fine-tune the properties of solid materials by introducing minute differences into a given cocrystal architecture.]]></summary_en></project><project>
<id>3468</id><title_hr><![CDATA[Cerebrovaskularna regulacija tijekom apneje kod elitnih ronilaca na dah]]></title_hr><title_en><![CDATA[Cerebrovascular regulation during apnea in elite breath-hold divers]]></title_en><user_id>7688</user_id><user_firstLast_name>Zeljko Dujic</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2014-09</proposal_call><code>IP-2014-09-1937</code><acronim><![CDATA[CEREBROFLOW]]></acronim><duration>28.09.2015 - 27.09.2019</duration><status>Završio</status><financ_value>132.722,81 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, Kliničke medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, Clinical sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Splitu, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Split School of Medicine]]></institution_en><team_members_id>12936, 12449, 12426, 1026, 12771, 12439, 12451, 1395, 12602, 4715, 7034, </team_members_id><team_members_names><![CDATA[Phil  Ainslie, Kevin Shoemaker, Otto Barak, Tonći Batinić, Marijana Karlovic-Vidakovic, Krešimir  Čaljkušić, Ivan Drviš, Damir Fabijanić, Arne Sieber, Mihajlo Lojpur, Toni Brešković, ]]></team_members_names><keywords_hr><![CDATA[Moždani protok krvi, moždani metabolizam, hipoksija, hiperoksija, hiperkapnija, hipokapnija]]></keywords_hr><keywords_en><![CDATA[Cerebral blood flow, cerebral metabolism, hypoxia, hyperoxia, hypercapnia, hypocapnia]]></keywords_en><summary_hr><![CDATA[Glavni cilj ovog prijedloga je da se sprovedu serije sve složenijih studija kojima bi se istražila nova fiziološka pitanja u sklopu fiziologije apneje, s posebnim naglaskom na fiziologiju mozga, te integraciju s cirkulacijskim i respiracijskim refleksima. Postavljanjem  novih znanstvenih pitanja u ovom prijedlogu želimo obogatiti i nadograditi naše razumijevanje temeljnih mehanizama moždanog protoka krvi u uvjetima teške hipoksije. Raščlanjivanje prirode odnosa između kisika, cerebralne perfuzije, moždanog metabolizma, te njihove važnosti za moždanu homeostazu je ključan korak prema razumijevanju fiziologije mozga u odnosu na ostale tjelesne sustave. Zadržavanje daha uzrokuje izniman stres za kardiovaskularni sustav i mozak, usprkos kojem elitni ronioci na dah uspijevaju tolerirati značajan pad kisika koji samo u ponekim slučajevima rezultira gubitkom svijesti (sinkopa). Mehanizmi odgovorni za adaptaciju ekstremnoj hipoksiji nam mogu poslužiti kao koristan model za istraživanje cerebrovaskularne regulacije tijekom prijetnje fiziološkoj homeostazi, kao što je to slučaj kod bolesti ili traume, tim više što je samo znanstveno istraživanje regionalne moždane perfuzije tijekom kardiorespiracijskih izazova, tjelesne aktivnosti i patoloških stanja tek u svojim začecima. Prema tomu, istraživanje regionalne cerebrovaskularne regulacije, te njene povezanosti s cirkulacijskim i respiracijskim sustavom kod zdravih, treniranih ronioca na dah će rezultirati novim uvidom u cerebrovaskularnu funkciju, kao i uvidom u integraciju ostalih sustava kod ljudi. Štoviše, rasvjetljavanje ovakvih mehanizama je od izuzetno velikog značaja za razumijevanje mnogobrojnih patoloških stanja vezanih uz arterijsku hipoksemiju i/ili promjene u viskoznosti krvi ili koncentraciji hemoglobina. ]]></summary_hr><summary_en><![CDATA[The main objective of this proposal is to propose and conduct a series of incrementally progressive studies to examine new physiological questions in apnea diving physiology, with particular focus on brain physiology and the related integration with circulatory and respiratory reflexes. Addressing the novel questions outlined in this proposal will enrich our understanding of the fundamental mechanisms governing cerebral blood flow in conditions of severe hypoxia. Characterization of these relationships between oxygen, cerebral perfusion and cerebral metabolism, and their respective importance on brain homeostasis is a fundamental step toward raising our understanding of brain physiology to that of other body systems. Breath holding exerts a potent stress to the cardiovascular system and brain, yet elite breath-hold divers are able to tolerate marked reductions in blood oxygenation that only sometimes results in loss of consciousness (syncope). The mechanisms allowing such tolerance to hypoxemic extremes may serve as a useful model for the study of cerebrovascular regulation during physiological duress often observed in trauma and disease. This is especially true given that the study of regional brain perfusion during cardiorespiratory challenges, exercise, and in pathology has only begun in the past several years. Thus, the study of regional cerebrovascular regulation and its relation to the circulatory and ventilatory in healthy, trained breath-hold divers will yield new insight into the cerebrovascular function and systems integration in humans. Moreover, elucidation of these mechanistic relationships is paramount to our comprehension of myriad pathologies associated with arterial hypoxemia and/or elevations in blood viscosity or hemoglobin levels.]]></summary_en></project><project>
<id>3469</id><title_hr><![CDATA[Arheologija jadranske brodogradnje i plovidbe]]></title_hr><title_en><![CDATA[Archaeology of Adriatic Shipbuilding and Seafaring]]></title_en><user_id>5521</user_id><user_firstLast_name>Irena Radić Rossi</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2014-09</proposal_call><code>IP-2014-09-8211</code><acronim><![CDATA[AdriaS]]></acronim><duration>01.06.2015 - 31.05.2019</duration><status>Završio</status><financ_value>79.633,69 eur</financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Arheologija, Filozofija, Povijest, </scie_field_hr><scie_field_en>Archeology, Philosophy, History, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zadru]]></institution_hr><institution_en><![CDATA[University of Zadar]]></institution_en><team_members_id>3152, 5919, 5995, 5955, 2704, 6254, 6111, 18977, 17691, 6346, 6426, </team_members_id><team_members_names><![CDATA[Luka Boršić, Jose Casaban, Mariangela Nicolardi, Suzana Čule, Danijel Dzino, Smiljko Rudan, Mate Parica, Katarina Batur, David Ruff, Giulia Boetto, Antonio Vasilijević, ]]></team_members_names><keywords_hr><![CDATA[arheologija broda, brodogradnja, plovidba, Jadransko more, 3D modeliranje, podvodna robotika, povijest tehnologije]]></keywords_hr><keywords_en><![CDATA[nautical archaeology, shipbuilding, seafaring, Adriatic Sea, 3D modellin, underwater robotics, history of technology]]></keywords_en><summary_hr><![CDATA[Osnovni cilj projekta je potencirati sustavno interdisciplinarno proučavanje i interpretaciju arheoloških i povijesnih svjedočanstava o istočnojadranskoj brodogradnji i plovidbi. Bogata jadranska pomorska povijest, promatrana sa stanovišta tehnološkog razvoja drvene brodogradnje i plovidbe kroz vrijeme,  nije se donedavno sustavno proučavala zbog nedostatka odgovarajućih sredstava i solidne metodološke osnove. Projekt uzima u obzir kognitivne i praktične sljedove tehnološkog razvoja brodogradnje i plovidbe, proučavajući međusobne odnose tehnologije s jedne, te političkog, ekonomskog i kulturno-povijesnog konteksta s druge strane. Usredotočen je na problematiku iz svih vremenskih razdoblja ljudske prošlosti (prapovijest, antika, srednji vijek i rani novi vijek) putem aktivnog terenskog rada, arhivskog istraživanja i eksperimentiranja u području virtualne stvarnosti. Počevši od problematike ilirskih lemba i liburnskih liburna, do složene problematike velikih kasnorenesansnih trgovačkih brodova, on pruža sveobuhvatan pregled postignuća dosegnutih u prošlosti, te u hrvatsku znanost uvodi sustavan metodološki pristup proučavanju brodskih konstrukcija. Oslanjajući se na stanje istraživanja u području arheologije broda i pomorske povijesti na svjetskoj razini, projekt ima za cilj uvesti najsuvremenije metode proučavanja starih brodova, njihove opreme i tereta. On potiče inovativan interdisciplinarni pristup u procesu istraživanja, dokumentiranja i interpretacije najznačajnijih izravnih materjalnih svjedočanstava o istočnojadranskoj pomorskoj povijesti, promovirajući međunarodnu suradnju i umrežavanje među mladim znanstvenicima. Takav koncept stvorit će velik potencijal za čitavu zajednicu i potaknuti širi interes javnosti, naročito putem promidžbe projekta u javnim medijima i korištenja generiranog znanja u hrvatskoj turističkoj promociji. ]]></summary_hr><summary_en><![CDATA[The aim of the project is to enhance systematic interdisciplinary study and interpretation of the archaeological and historical record of shipbuilding and seafaring in the Eastern Adriatic. Its rich maritime history, seen through the technological development of wooden shipbuilding and seafaring and the dynamics that affected them over time, has not been systematically researched until recently, due to the lack of appropriate resources and the absence of a sound methodological basis. The project considers the cognitive and practical sequences of the technological development of shipbuilding and seafaring, studying the relationship between technology on one hand and the political, economic and cultural/historical context on the other. It focuses on issues from all periods of the human past (Prehistory, Classical Antiquity, Middle Ages and Early Modern period) through active fieldwork, archival research and virtual reality experimentation. From the problematic histories of the Illyrian lemboi and Liburnian liburnae, to the complex issues of the large late Renaissance merchantmen, it provides a comprehensive overview of the past achievements, and introduces into Croatian research the systematic methodological approach to the study of the ships’ hulls. Taking into consideration global state-of-the-art practices in the fields of nautical archaeology and maritime history, the project aims to introduce cutting edge methodologies of study of ancient ships, their equipment and cargoes. It will foster an innovative interdisciplinary approach in the process of research, recording and interpretation of the most significant direct material evidence of the Eastern Adriatic maritime past, while promoting international collaboration and networking among young researchers. Such concept will have great potential for community outreach and wider public interest, especially through promoting project in public media as well as using new knowledge in Croatian touristic promotion.]]></summary_en></project><project>
<id>3471</id><title_hr><![CDATA[Matrične faktorizacije i blok dijagonalizacijski algoritmi]]></title_hr><title_en><![CDATA[Matrix Factorizations and Block Diagonalization Algorithms]]></title_en><user_id>8764</user_id><user_firstLast_name>Vjeran Hari</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2014-09</proposal_call><code>IP-2014-09-3670</code><acronim><![CDATA[MFBDA]]></acronim><duration>01.05.2015 - 30.04.2019</duration><status>Završio</status><financ_value>76.266,51 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Matematika, </scie_field_hr><scie_field_en>Mathematics, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>13190, 13175, 13174, 13186, 13170, 13177, 18973, </team_members_id><team_members_names><![CDATA[Saša Singer, Erna Begović, Neven Krajina, Josip Matejaš, Vedran Novaković, Sanja Singer, Saša Stanko, ]]></team_members_names><keywords_hr><![CDATA[Matrice, matrične faktorizacije, blok algoritmi,  software, efikasnost, točnost, konvergencija]]></keywords_hr><keywords_en><![CDATA[Matrices, matrix factorizations, block algorithms, software, efficiency, accuracy, convergence]]></keywords_en><summary_hr><![CDATA[Matrične faktorizacije čine osnovni alat za rješavanje cijelog niza problema iz znanosti, inženjerstva i privrednih djelatnosti. Iako za navedene probleme postoje mnogi algoritmi i razvijena teorija, još uvijek postoji niz neriješenih problema. Cilj ovog projekta je proučavanje i poboljšavanje postojećih te otkrivanje novih algoritama Jacobijevog tipa za obični i generalizirani matrični problem svojstvenih i singularnih vrijednosti, kao i realne Schurove dekompozicije. Kao pomoćne algoritme razvit ćemo visoko točne algoritme za (običnu i hiperbolnu) singularnu dekompoziciju i za kosinus-sinus faktorizaciju ortogonalnih i J-ortogonalnih matrica. Budući da ortogonalne i J-ortogonalne matrice pripadaju klasi ortosimetričnih matrica, radit ćemo na razvoju algoritama i teorije za takve matrice sa specijalnom strukturom.Suvremeni matrični algoritmi moraju biti efikasni (što se postiže blok organizacijom algoritma, uz korištenje BLAS3 potprograma), robusni, stabilni i prilagodljivi za upotrebu na najnovijim računalnim resursima (CPU i GPU paralelizacija). Budući da mnoge algoritme dijagonalizacijskog tipa krasi relativna točnost i inherentni paralelizam, oni su idealni izbor za spomenute matrične probleme. Jedan od ciljeva ovog projekta je razvoj novih sekvencijalnih i paralelnih blok algoritama, jer oni na prirodni način generaliziraju i poboljšavaju postojeće algoritme. Za takve nove algoritme testirat će se njihova efikasnost, dokazivati globalna i asimptotička konvergencija te ocjenjivati njihova relativna točnost.Uspjeh projekta garantira sastav istraživača, jer su okupljeni dokazani stručnjaci iz teorije matrica i matričnih algoritama, kao i iz znanstvenog računanja, te nekoliko doktoranada koji su već pokazali snažan interes za matričnu teoriju i praksu. Kao rezultat rada na projektu očekujemo više od 10 znanstvenih radova u vrhunskim svjetskim časopisima i još 5-6 radova u časopisima koje referira SCIE lista. Razvit će se i testirati up-to-date software za spomenute algoritme.]]></summary_hr><summary_en><![CDATA[Matrix factorizations are the main tool for solving a wide variety of problems from science, engineering and economic activities. Although there are many algorithms that solve these problems and the theory is well developed, many unanswered questions still remain and so major improvements are possible. The aim of this project is to study and improve the existing and to develop new Jacobi-type algorithms for standard and generalized eigenvalue and singular value problems and real Schur decomposition. As ancillary algorithms a highly accurate algorithms for the standard and hyperbolic singular value decompositions and cosine-sine factorizations of orthogonal and J-orthogonal matrices will be developed. The last two belong to the class of orthosymmetric matrices and we intend to study structured matrices in this class and work on the efficient algorithm development.Modern numerical algorithms must be efficient, robust, stable and adaptable for use on the latest computing resources (CPU and GPU parallel processing). Since many of the standard diagonalization algorithms are adorned with high relative accuracy and inherent parallelism, one of the goals of this project is the development of new sequential and parallel block algorithms. Theoretically, their global and maybe the quadratic asymptotic convergence will be proved and high relative accuracy estimated.The success of the project is guaranteed by the selection of the researchers in the team. The team is comprised of experts with a proven track record in the theory of matrices and matrix (especially Jacobi-type) algorithms, together with experts in scientific computing and also several doctoral students who have already shown a strong interest in matrix theory and applications. As output of the project, it is expected that more than 10 papers will be published in leading scientific journals and several (5-6) in journals on the SCIE list, the complementary software will be developed and the algorithms implemented.]]></summary_en></project><project>
<id>3472</id><title_hr><![CDATA[TERAPIJSKI POTENCIJAL ORALNE GALAKTOZE U EKSPERIMENTALNOJ ALZHEIMEROVOJ BOLESTI]]></title_hr><title_en><![CDATA[THERAPEUTIC POTENTIAL OF ORAL GALACTOSE IN EXPERIMENTAL ALZHEIMER&#39;S DISEASE]]></title_en><user_id>1198</user_id><user_firstLast_name>Melita Šalković-Petrišić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2014-09</proposal_call><code>IP-2014-09-4639</code><acronim><![CDATA[GALAD]]></acronim><duration>15.09.2015 - 14.09.2018</duration><status>Završio</status><financ_value>99.542,11 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb School of Medicine]]></institution_en><team_members_id>1191, 3079, 4375, 3239, </team_members_id><team_members_names><![CDATA[Ana Knezović, Jelena  Osmanović Barilar, Andrija Lončar, Peter Riederer, ]]></team_members_names><keywords_hr><![CDATA[oralna galaktoza, streptozotocin, transgenični Tg2576 miševi, Alzheimerova bolest, glukagonu sličan peptid-1]]></keywords_hr><keywords_en><![CDATA[oral galactose, streptozotocin, transgenic Tg2576 mice, Alzheimer&#39;s disease, glucagone-like peptide-1]]></keywords_en><summary_hr><![CDATA[Cilj istraživanje je ispitati novi terapijski pristup Alzheimerovoj bolesti (AB), kao najčešćem obliku demencije. Porastom dokaza o inzulinskoj rezistenciji u mozgu (IRM) i cerebralnom metaboličkom poremećaju kao medijatorima sporadične AB (sAB), normaliziranje inzulinske signalizacije i posljedičnih poremećaja u mozgu postali su novi ciljevi u liječenja AB. Poseban doprinos istraživanja je karakterizacija terapijskog potencijala oralno primijenjene galaktoze u životinjskim modelima koji oponašaju sAB i familijarnu AB. Model za sAB su štakori s intracerebroventrikularnom primjenom streptozotocina (STZ-icv model) koja inducira nastajanje IRM i vremenom pojavu mnogih sAB-u sličnih obilježja. Model za familijarnu AB su transgenični Tg2576 miševi koji vremenom pokazuju neke od znakova IRM. Galaktoza je alternativni izvor energije; ulazi u stanice inzulin-neovisnim nosačem za glukozu GLUT3 i metabolizira se u glukozu. Nedavni rad glavnog ispitivača pokazao je da oralna galaktoza sprečava nastajanje kognitivnih deficita u štakorskom STZ-icv modelu. Ovo će istraživanja ispitati sprečava li ih u Tg2576 miševa te ublažava li već nastale kognitivne deficite u oba modela. Inovativni aspekt projekta je u rasvjetljavanju učinaka posredovanih oralnom galaktozom; poboljšanja cerebralnog unosa glukoze i stimulacije sekrecije glukagonu-sličnog peptida-1 (GLP-1) te njihove korelacije s kognitivnim poboljšanjem. Za utvrđivanje učinka 2-mjesečne primjene oralne galaktoze na poremećaje pamćenja koristit će se Morris Water Maze i Passive Avoidance testovi, radio-obilježenim ligandom pratit će se metabolizam glukoze u mozgu, dok će se Western blot analizom, imunohistokemijom i enzimskim imunoadsorpcijskim testom odrediti razina GLUT3/GLUT4 i inzulin-razgrađujućeg enzima, tau i amiloidna patologija u mozgu te količina galaktoze, inzulina i GLP-1 u plazmi i likvoru. Rezultati projekta generirat će nove spoznaje i omogućiti značajan uvid u novi, na nutrijentu temeljeni pristup liječenju AB.]]></summary_hr><summary_en><![CDATA[This project aims to explore a novel therapeutic strategy in Alzheimer’s disease (AD), the most common form of dementia. Owing to growing evidence of brain insulin resistance (BIR) and cerebral metabolic dysfunction being the mediators of sporadic AD (sAD), restoring of brain insulin signalling and downstream defects has recently become a new target in AD treatment research. Unique contribution of this proposal is in characterization of the therapeutic potential of oral galactose in animal models which mimic sAD and familial AD. The former is generated by streptozotocin-intracerebroventricular application (STZ-icv rat) which induces BIR and eventually develops many of sAD-like features, and the latter is transgenic Tg2576 mice which eventually show some signs of BIR. Galactose is alternative source of energy; it enters the cell via insulin-independent glucose transporter GLUT3 and is metabolized to glucose. PI’s recent publication indicates that oral galactose prevents development of cognitive deficits in STZ-icv rat model. This research will explore if it can prevent them in Tg2576 mice and ameliorate already developed cognitive deficits in both Tg2576 mice and STZ-icv rats. Innovative aspect of the proposal is elucidation of oral galactose-mediated improvement in cerebral glucose uptake and stimulation of glucagone-like peptide-1 (GLP-1) secretion, and their correlation to cognitive improvement in both models. Morris Water Maze and Passive Avoidance tests, radio-tracing of brain glucose metabolism, Western blot analysis, Enzyme-Linked Immunosorbent Assays and immunohistochemistry will be used to detect effects of 2-month oral galactose treatment on memory loss, GLUT3/GLUT4 and insulin degrading enzyme levels, tau and amyloid-ß pathology in the brain, and galactose, insulin and GLP-1 levels in blood/cerebrospinal fluid. Project results will gain new knowledge and provide significant insights into a novel nutrient-related therapeutic strategy in AD treatment.]]></summary_en></project><project>
<id>3473</id><title_hr><![CDATA[Holografija i interferometrija u uvjetima niske razine svjetlosti]]></title_hr><title_en><![CDATA[Holography and interferometry under weak illumination]]></title_en><user_id>5159</user_id><user_firstLast_name>Nazif Demoli</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2014-09</proposal_call><code>IP-2014-09-7515</code><acronim><![CDATA[HI-WI]]></acronim><duration>01.05.2015 - 31.05.2019</duration><status>Završio</status><financ_value>128.342,96 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, </scie_field_hr><scie_field_en>Physics, </scie_field_en><institution_hr><![CDATA[Institut za fiziku]]></institution_hr><institution_en><![CDATA[Institute of Physics in Zagreb]]></institution_en><team_members_id>4857, 5697, 5141, 1037, 6611, 5148, 5293, </team_members_id><team_members_names><![CDATA[Hrvoje Skenderović, Mario Stipčević, Mladen Pavičić, Marin Karuza, Ognjen Milat, JADRANKO GLADIĆ, Davorin Lovrić, ]]></team_members_names><keywords_hr><![CDATA[holografija, digitalna holografija, interferometrija, numerički hologrami, brojanje fotona, kvantna kontekstualnost]]></keywords_hr><keywords_en><![CDATA[holography, digital holography, interferometry, numerical holograms, photon counting, quantum contextuality]]></keywords_en><summary_hr><![CDATA[Primarni interes ovog projekta je unaprijediti korištenje sustava i metoda temeljenih na digitalnoj holografiji i interferometriji u uvjetima niske razine svjetlosti, kao nastavak nedavnih dostignuća (Demoli i ostali, Opt. Lett. 39, 5010, 2014). U takvim uvjetima, standardni CCD zapisi digitalnih holograma pate od nedostatka informacija, jer su ili zasjenjeni šumom ili izravnati dubinom bit pretvorbe. Pokazali smo da se originalna informacija može efikasno sačuvati korištenjem detektora pojedinačnih fotona (PCD) umjesto CCD senzora i velikog dinamičkog raspona koji posjeduje PCD. Motivirani smo proširiti prethodno istraživanje na ostale holografske i interferometrijske tehnike kao i na kontekstualne eksperimente i interferometriju visoke osjetljivosti. Kao rezultat ovog projekta, bit će također razvijeni specijalizirani detektori pojedinačnih fotona te metoda direktnog laserskog upisivanja holograma.Glavni zadaci projekta su:(i) Istraživanje uloge eksperimentalnih parametara za snimanje vremenski usrednjenih i impulsnih digitalnih holograma u uvjetima niske razine svjetlosti. Očekivani rezultati su: pronalaženje optimalnog raspona glavnih parametara snimanja (omjer snopova, vrijeme ekspozicije, SNR, kontrast) i eksperimentalnih ograničenja zbog sprege različitih frekvencija (titranje površine, laserski puls, brzina PCD-a). (ii) Implementiranje kontekstualnih eksperimenata pomoću polarizacije i orbitalnog angularnog momenta fotona. Očekivani rezultat je demonstrirati kvantnu kontekstualnost u četvero-dimenzionalnom Hilbertovom prostoru na novi način koji se razlikuje od dosadašnjih.(iii) Istraživanje kvantnog efekta fotona u Fabry-Perot šupljini pomoću interferometrije visoke osjetljivosti. Očekivani rezultat je demonstrirati da samo kvantna teorija može objasniti raspodjelu događaja unutar zadanog vremenskog prozora.(iv) Razvoj specijaliziranih detektora brojanja pojedinačnih fotona i tehnike direktnog upisivanja holograma.]]></summary_hr><summary_en><![CDATA[The primary interest of this project is to advance the use of digital holography and interferometry based systems and techniques under the conditions of weak illumination, as a continuation of recent achievements (Demoli et al., Opt. Lett. 39, 5010, 2014). In such conditions, the standard CCD recordings of digital holograms suffer from the lack of information, since they are either obscured by noise or flattened by the bit depth conversion. We have shown that by using a photon counting detector (PCD) instead of a CCD sensor and by employing high dynamic range of the PCD, the original information can be efficiently preserved. We are motivated to extend the previous research to other holography and interferometry techniques as well as to perform contextual experiments and experiments in high-sensitivity interferometry. As a result of this project, the specialized photon counting detectors and direct laser hologram writing technique will be also developed.Main tasks of the project include:(i) Investigation of the role of the experimental parameters for recording the time-averaged and pulsed digital holograms under weak illumination. Expected results are: finding the optimum range of main recording parameters (beam ratio, exposure time, SNR, contrast) and experimental limitations due to coupling of various frequencies (surface vibrations, laser pulse, repetition rate of PCD).(ii) Implementation of contextual experiments by means of photon polarization and orbital angular momentum. Expected result is to demonstrate quantum contextuality in a four-dimensional Hilbert space in a new way different from previous.(iii) Investigation of a quantum effect of a photon buildup in a Fabry-Perot cavity by employing high-sensitivity interferometry. Expected result is to demonstrate that only quantum theory can explain the distribution of events within a given time window.(iv) Developments of the specialized photon counting detectors and direct laser writing of holograms technique.]]></summary_en></project><project>
<id>3476</id><title_hr><![CDATA[Utjecaj podrijetla i izolacije na ADME gene: primjer romske populacije]]></title_hr><title_en><![CDATA[Impact of ancestry and isolation on ADME genes - the Roma example]]></title_en><user_id>12348</user_id><user_firstLast_name>Marijana Peričić Salihović</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2014-09</proposal_call><code>IP-2014-09-4454</code><acronim><![CDATA[ADMEROMA]]></acronim><duration>01.09.2015 - 31.12.2019</duration><status>Završio</status><financ_value>127.254,63 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Biologija, </scie_field_hr><scie_field_en>Biology, </scie_field_en><institution_hr><![CDATA[Institut za antropologiju]]></institution_hr><institution_en><![CDATA[Institute for Anthropological Research]]></institution_en><team_members_id>12595, 12594, 12597, 12895, 12592, 25214, </team_members_id><team_members_names><![CDATA[Branka Janićijević, Nina Smolej Narančić, TATJANA ŠKARIĆ-JURIĆ, Matea Zajc Petranović, Željka Tomas, Anita Stojanović Marković, ]]></team_members_names><keywords_hr><![CDATA[ADME geni, Romi, izolacija, populacijska struktura, polimorfizmi, CYP2D6, CYP1A2]]></keywords_hr><keywords_en><![CDATA[ADME genes, Roma, isolation, population structure, polymorphisms, CYP2D6, CYP1A2]]></keywords_en><summary_hr><![CDATA[Genomska raznolikost suvremenih populacija odražava demografske i evolucijske događaje u prošlosti što se posebno očituje u izoliranim populacijama. Romi su primjer populacije utemeljitelja u kojoj je višestoljetna sociokulturna izolacija ostavila tragove u zalihi gena, vidljive u znatnoj genskoj različitosti Roma od drugih populacija. ADME geni, odgovorni za apsorpciju, distribuciju, metabolizam i izlučivanje lijekova, ubrajaju se u one koji pokazuju značajnu varijabilnost među populacijama. Unatoč dokazanoj funkcionalnoj ulozi, znanje o njihovoj distribuciji u izoliranim populacijama vrlo je ograničeno. Stoga u ovom projektu namjeravamo istražiti polimorfizme ADME gena analizom temeljnih ADME biljega i gena CYP2D6 i CYP1A2 na uzorku od 300 osoba, pripadnika triju različitih romskih skupina iz Hrvatske. Glavni je cilj projekta odrediti varijacije ADME gena u romskoj populaciji kako bi se utvrdio utjecaj višestrukih učinaka utemeljitelja i uskog grla, izolacije i endogamije na ovu važnu skupinu gena. Taj cilj bit će postignut provedbom analize populacijske strukture, procjenom starosti mutacija i funkcionalnom analizom in silico. Očekujemo da ćemo pronaći specifične razdiobe alela istraživanih lokusa unutar ADME gena, kao i genske osobitosti koje odražavaju indijsko podrijetlo Roma te pokazatelje koji upućuju na tok gena između romske i drugih populacija s kojima su dolazili u doticaj tijekom migracija iz Indije u Europu. Novoutvrđeni ADME genski profil svojstven romskoj populaciji bit će važan za svakodnevnu medicinsku praksu pri modulaciji farmakoterapije. Također, dobiveni će rezultati doprinijeti farmakogenetici upotpunjavanjem slike o varijacijama ADME gena kod Roma te omogućiti primjenu tih spoznaja u razvoju farmakogenetičkih testova specifičnih za ovu manjinsku populaciju koja u svijetu broji preko 15 milijuna ljudi. Očekujemo da će rezultati istaknuti populacijsku specifičnost ADME gena i potaknuti provedbu takvih istraživanja u ostalim izolatima svijeta.]]></summary_hr><summary_en><![CDATA[Contemporary populations’ genomic diversity reflects past demographic and evolutionary events, pronounced in isolated populations. The Roma is an example of a founder population with centuries long sociocultural isolation which left traces in their gene pool which shows considerable differences compared with other populations. The genes that significantly differentiate among populations are those responsible for absorption, distribution, metabolism and excretion of drugs (ADME genes). The knowledge on their distribution in isolated populations is limited. Therefore, in this application we propose to study ADME genes&#39; polymorphisms through the analysis of ADME core markers and CYP2D6 and CYP1A2 genes in 300 DNA samples obtained from three Roma groups in Croatia. The general objective of this project is to determine the variation of ADME genes in Roma population, to assess the extent to which the population history which includes multiple bottleneck/founder events, isolation and endogamy impacted this important gene family. This will be achieved through population structure analysis, the assessment of the age of mutations and in silico functional analysis. We expect to find specific allele distributions of the investigated loci within the ADME genes, landmarks that reflect the Indian origin of the Roma and the signals of admixture with the populations they came in close contact with in the past during their migration from India to Europe. Our assessment of Roma’ unique genetic profile will contribute to the medical practice through the modulation of pharmacotherapy in Roma population. It will also significantly contribute to the field of pharmacogenetics in terms of information on the genetic variation in Roma, essential for the development of pharmacogenetic tests specific for this minority population estimated to around 15 million people. The results promise to highlight the population uniqueness in ADME genes and encourage similar research in the world’s isolates.]]></summary_en></project><project>
<id>3478</id><title_hr><![CDATA[Klostridijski neurotoksini i mozak]]></title_hr><title_en><![CDATA[Clostridial Neurotoxins and Brain]]></title_en><user_id>3574</user_id><user_firstLast_name>Zdravko Lackovic</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2014-09</proposal_call><code>IP-2014-09-4503</code><acronim><![CDATA[BrainTox]]></acronim><duration>20.10.2015 - 19.10.2017</duration><status>Završio</status><financ_value>66.361,40 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, Kliničke medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, Clinical sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb School of Medicine]]></institution_en><team_members_id>4119, 6881, 4059, 6200, 13244, 3885, 3901, 4022, 13617, </team_members_id><team_members_names><![CDATA[Maja Relja, Claudia Sommer, Boris Filipović, Zsuzsanna Helyes, Matteo Caleo, Lidija Bach-Rojecky, Višnja Drinovac, Ivica Matak, Nataša  Klepac , ]]></team_members_names><keywords_hr><![CDATA[botulinum toksin A, tetanus toksin, bol, antinociceptivno djelovanje, motorni sustav, ne-motorni središnji učinci]]></keywords_hr><keywords_en><![CDATA[botulinum toxin A, tetanus toxin, pain, antinocieptive activity, motor system, non-motor central effects]]></keywords_en><summary_hr><![CDATA[Botulinum toksini (BTX) i tetanus toksin (TTX) su najvažniji klostridijski toksini, i među najtoksičnijim tvarima u prirodi. Jedan gram BTX tipa A (BTX-A) može ubiti više od milijun ljudi inhalacijom. Istovremeno, BTX-A se često koristi u terapijske svrhe, a kozmetička primjena je najraširenija (Botox).Danas se njegova primjena u određenih vrsta boli povećava. Dugotrajno djelovanje I sigurnost su od naročite kliničke važnosti. Do nedavno se vjerovalo da je osnovni mehanizam antinociceptivnog djelovanja BTX-A vezan uz periferne živčane okončine, a posredovan cijepanjem SNAP-25, proteina uključenog u lučenje neurotransmitora.Rezultati iz našeg laboratorija su prvi pokazali da BTX-A retrogradno putuje s periferije u  središnji živčani sustav kroz senzorne neurone, te središnje mjesto djelovanja na bol. Međutim, točan mehanizam je nerazjašnjen. Stoga su glavni ciljevi projekta istraživanje: I. Utjecaja BTX-A na opioidne receptore i opioidne peptide, te uključenost glutamatnih receptora; uloga spinalnih i supraspinalnih glija stanica u antinociceptivnom djelovanju BTX-A;II. Mehanizma središnjeg djelovanja BTX-A na bilateralnu bol;III. Povezanosti kapsaicin-osjetljivih neurona i antinociceptivnog djelovanja BTX-A;IV. Učinka BTX-A na trigeminovaskularni sustav i peptid srodan genu za kalcitonin, kao mogući mehanizam njegovog djelovanja na migrenu;V. Središnjih učinaka BTX-A na motorni sustav; VI. Usporedbe BTX-A i TTX temeljm pretpostavke da injiciranje malih količina TTX u senzorne živce i ganglije može također utjecati na bol.VII. Istovremeno s eksperimentalnim istraživanjima, promatrat će se učinak BTX-A na različite ne-motorne funkcije u pacijenata s migrenom ili distonijom. To čini naš projektni prijedlog translacijskim istraživanjem. Predložena istraživanje mogu objasniti učinke BTX-A na kroničnu bol, migrenu i hiperkinetske poremećaje pokreta što može značajno unaprijediti njegovu kliničku primjenu.]]></summary_hr><summary_en><![CDATA[Botulinum toxins (BTX) and tetanus toxin (TTX) are the most important clostridial neurotoxins and one of the most toxic substances in nature. One gram of BTX type A (BTX-A) could kill more than one million people via inhalational route. At the same it is often used for therapeutic, especially cosmetic purposes (Botox).Today, BTX-A use in certain types of pain is increasing. Long-term effectiveness and safety are of a special clinical value. Until recently it was believed that the primary mechanism of BTX-A antinociceptive action is at peripheral nerve endings, mediated by prevention of neurotransmitter release, caused by cleavage of SNAP-25, protein required for exocytosys. We revealed for the first time the BTX-A retrograde transport from the periphery to the CNS in sensory nerves, and the central site of action. However, the exact mechanism is yet unresolved. Thus, main goals of our research are to study: I. BTX-A influence on opioid receptors and opioid peptides and involvement of glutamate receptors; the role of spinal and supraspinal glia in antinociceptive action of BTX-A;II. The mechanism of BTX-A central action on bilateral pain;III. The association of capsaicin-sensitive neurons and BTX-A antinociceptive activity; IV. The effect of BTX-A on trigeminovascular system and calcitonin gene-related peptide, as a possible mechanism of its antimigraine action;V. The potential central effects of BTX-A in motor system;VI. Comparison of BTX-A to TTX, based on assumption that application of small amounts of TTX into sensory nerves and ganglia could have the effect on pain.VII. In parallel, the effect of BTX-A on various non-motor functions in migraine or dystonic patients will be studied. This makes our research also a translational research.Proposed project could lead to the explanation of BTX-A mechanisms of action in chronic pain, migraine, and hyperkinetic movement disorders, which would make an important contribution to possible refinement of its clinical use. ]]></summary_en></project><project>
<id>3479</id><title_hr><![CDATA[PRIMJENA CIJEVNIH PROPUSTA ZA POBOLJŠANJE KVALITETE MORA U LUKAMA/MARINAMA]]></title_hr><title_en><![CDATA[IMPLEMENTATION OF THE FLUSHING CULVERTS FOR THE IMPROVEMENT OF THE SEA QUALITY IN HARBOURS/MARINAS (EKO MARINA)]]></title_en><user_id>4885</user_id><user_firstLast_name>Dalibor Carević</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2014-09</proposal_call><code>UIP-2014-09-6774</code><acronim><![CDATA[EKO MARINA]]></acronim><duration>01.10.2015 - 30.09.2018</duration><status>Završio</status><financ_value>78.073,82 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Građevinarstvo, </scie_field_hr><scie_field_en>Civil engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Građevinski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Civil Engineering]]></institution_en><team_members_id>6656, 6250, 3007, 4827, 13609, 13662, 18927, 18928, 21304, </team_members_id><team_members_names><![CDATA[GORAN  LONČAR, Gordon Gilja, Gordana Beg Paklar, Hrvoje MOSTEČAK, Vasiliki Tsoukala, Predrag Vukadin, Ivana Bartolić, Igor Ružić, Ratko Ramuščak, ]]></team_members_names><keywords_hr><![CDATA[cijevni propusti, izmjena mora, vrijeme zadržavanja, cirkulacija u luci, eko marina]]></keywords_hr><keywords_en><![CDATA[flushing culverts, residence time, flushing time, sea exchange, eko marina]]></keywords_en><summary_hr><![CDATA[Ovaj projekt donosi zaključke o mjerama koje trebaju biti primijenjene u svrhu osiguranja dovoljne izmjene vode u budućim lukama upotrebom cijevnih propusta. Ugradnja cijevnih propusta u konstrukciju lukobrana je najjeftinija metoda, između ostalih. Svrha cijevnih propusta je da omoguće izmjenu vode između otvorenog mora i mora zatvorenog u luci. Generalno postoji manjak znanja koji bi opisivao funkcioniranje cijevnih propusta kao instrumenta za izmjenjivanje vode. Slijedeća pitanja trebaju biti odgovorena kroz faze ovoga projekta: 1. FAZA I: Koja se veličina protoka ostvaruje u propustima pod djelovanjem vjetrovnih valova, i kolika je vrijednost transmitirane valne energije? Metodologija: Fizikalni model u laboratoriju (u valnom kanalu) sa modelom cijevnih propusta. 2. FAZA II: Funkcioniranje cijevnih propusta u realnim uvjetima (u stvarnoj luci), što znači, složeni uvjeti istovremenog djelovanja valova s vanjske strane luke zajedno sa plimnim oscilacijama i vjetrovnom cirkulacijom mora (koji je protok u propustima u takvim uvjetima?). Metodologija: Sveobuhvatna terenska mjerenja u marini Ičići (Opatija) u svrhu kalibracije 3D numeričkog modela. 3. FAZA III: Koliko pozija propusta u tijelu lukobrana doprinosi protoku u propustima? Metodologija: 3D numeričko modeliranje.Općenita svrha istraživanja je razotkriti funkcioniranje cijevnih propusta korištenjem laboratorijskih modela, terenskih istraživanja i numeričkog modeliranja. Rezultat istraživanja će biti inženjerske preporuke i jednostavni matematički modeli (jednadžbe, grafovi) koji će pomoći inženjerima u optimalnom projektiranju cijevnih propusta.]]></summary_hr><summary_en><![CDATA[This project provide conclusions on measures that need to be implemented in order to secure enough exchange of water mass in future harbors using flushing culverts (pipes). Installation of flushing culverts inside the breakwater structure is the most cost-effective method, among others. The purpose of culverts is to enable the exchange of the open sea water and the water contained within a protected maritime zone. There is a general lack in research that would provide an explanation on how pipe culverts actually work as a sea water exchange instrument. The next answers should be reached through phases of this project. 1. PHASE I: What is the amount of water discharge in culverts under the agency of surface wind waves, and what is the amount of wave energy transmission?. Methodology: Physical model in laboratory (wave channel) with flushing culverts model. 2. PHASE II: Functioning of flushing culverts in a realistic conditions (in real harbor), which means, the complex conditions of simultaneous actions of waves coming from outside a harbor along with tidal oscillations and wind driven circulation of sea (what is the water discharge in culverts in such conditions?). Methodology: Extensive field measurements in Ičići marina (Opatija) with purpose on calibration of 3D numerical model . 3. PHASE III: How much does positions of culverts in breakwater’s body contributes to the culverts discharge? Methodology: 3D numerical modelling. The overall purpose of the research is to discover flushing culverts functioning using laboratory models, field measurements and numerical modelling The result of the research would be engineering guides and simple mathematical models (equations, graphs) that would help engineers in optimal design of the flushing culverts. ]]></summary_en></project><project>
<id>3480</id><title_hr><![CDATA[Približavanje strategije i prakse nagrađivanja hrvatskih poduzeća europskoj praksi]]></title_hr><title_en><![CDATA[Closing the gap in compensation strategy and practice between Croatia and EU]]></title_en><user_id>12985</user_id><user_firstLast_name>Lovorka Galetić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2014-09</proposal_call><code>IP-2014-09-5600</code><acronim><![CDATA[CompCroEU]]></acronim><duration>15.09.2015 - 14.12.2018</duration><status>Završio</status><financ_value>37.777,75 eur</financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Ekonomija, </scie_field_hr><scie_field_en>Economy, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Ekonomski fakultet u Zagrebu]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Economics and Business]]></institution_en><team_members_id>12588, 13589, 13596, 3081, </team_members_id><team_members_names><![CDATA[Ivana Načinović Braje, MAJA KLINDŽIĆ, Danica Bakotić, Ivana Šandrk Nukić, ]]></team_members_names><keywords_hr><![CDATA[kompenzacijski menadžment, strategija nagrađivanja, sustav nagrađivanja, plaća, beneficije, ]]></keywords_hr><keywords_en><![CDATA[compensation management, compensation strategy, reward system, pay, benefits, ]]></keywords_en><summary_hr><![CDATA[Kompenzacijski menadžment obuhvaća organizirani skup organizacijskih praksi koje su usmjerene na reguliranje odnosa između poslodavca i zaposlenika, na način da se zaposlenicima za uloženo vrijeme i trud osiguraju odgovarajuće materijalne i nematerijalne nagrade. Kompenzacije su ključni element u međusobnom odnosu poslodavca i zaposlenika.  Za mnoga poduzeća kompenzacije predstavljaju najveći pojedinačni operativni izdatak, te su istodobno prepoznate kao mehanizam za povećanje uspješnosti organizacije te održavanje konkurentnosti. Uslijed snažnog utjecaja kompenzacijskog menadžmenta na sveukupnu uspješnost organizacija, prepoznata je važnost proučavanja ove tematike među hrvatskim poduzećima. Štoviše, obzirom da hrvatska poduzeća odnedavno spadaju u sastavni dio većeg internog tržišta Europske Unije (EU) na kojem su zagarantirani mobilnost i sloboda kretanja, prepoznata je važnost konkurentnosti praksi kompenzacijskog menadžmenta primijenjenih u hrvatskim poduzećima u širem kontekstu EU. Istraživanje je usmjereno na komparativnu analizu strategija i praksi nagrađivanja primijenjenih u Hrvatskoj i zemljama EU, kako bi se dodatno produbilo znanje o ovom području, odnosno sve u cilju razvijanja strategija nagrađivanja koje će omogućiti hrvatskim poduzećima jačanje konkurentnosti i umanjiti odlazak zaposlenika na strana tržišta rada. Sinteza analize dostupnih spoznaja, kao i povedenog istraživanja, omogućila bi razvijanje skupa preporuka za hrvatska poduzeća kako primijeniti suvremene prakse u nagrađivanju u hrvatskom kontekstu. Također, temeljem svih prikupljenih rezultata osmislili bi se i provodili programi edukacije za specijaliste za kompenzacije. Komparativne studije s ovakvom tematikom su nepostojeće te bi stoga upravo ovo istraživanje predstavljalo dodatni iskorak u istraživanju promatranog područja. ]]></summary_hr><summary_en><![CDATA[Compensation management is an organized organizational practice that involves balancing the employer-employee relation by providing monetary and non-monetary benefits to employees for their time and effort. Compensation is a key element of the employment relationship and, in addition to being the single greatest operating cost for many organizations, it has been advocated as a tool for enhancing organizational performance and sustained competitiveness. Due to high impact of compensation management on overall firm performance, we recognized the need to research it in detail within Croatian companies. Furthermore, since Croatian companies constitute just a part of the larger European Union (EU) market in which mobility and free movement of persons is guaranteed we thus find that compensation management strategies and practices used by Croatian companies must be competitive within larger EU context. This research is aimed at making comparative research of Croatian and EU countries’ compensation strategies and practices in order to develop knowledge on the topic, all with the purpose of developing compensation strategies that would allow Croatian companies to increase their relative competitiveness and reduce excessive employee drain to foreign labour markets. Besides scientific dissemination, research findings would allow developing recommendations for Croatian companies how to use state-of-the art compensation practices applied to Croatian context and would be used as inputs in developing education programs for compensation specialists. Comparative studies exploring such gap and its implications are non-existent. This study should therefore represent an early and exploratory approach toward developing this field.]]></summary_en></project><project>
<id>3487</id><title_hr><![CDATA[Napredni sustavi bušenja u koštano-zglobnoj kirurgiji]]></title_hr><title_en><![CDATA[Advanced Drilling Systems in Bone and Joint Surgery]]></title_en><user_id>13622</user_id><user_firstLast_name>Toma  Udiljak</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2014-09</proposal_call><code>IP-2014-09-9870</code><acronim><![CDATA[ADRISS]]></acronim><duration>15.09.2015 - 14.09.2018</duration><status>Završio</status><financ_value>75.585,64 eur</financ_value><scie_area_hr>Tehničke znanosti, Biomedicina i zdravstvo, </scie_area_hr><scie_area_en>Technological sciences, Biomedicine and health sciences, </scie_area_en><scie_field_hr>Strojarstvo, Elektrotehnika, Računarstvo, Kliničke medicinske znanosti, </scie_field_hr><scie_field_en>Mechnical engineering, Electrical engineering, Computer sciences, Clinical sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet strojarstva i brodogradnje]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Mechanical Engineering and Naval Architecture]]></institution_en><team_members_id>13485, 13549, 6544, 12778, 12930, 13147, 13484, 13591, 12708, 4841, 13645, </team_members_id><team_members_names><![CDATA[Dubravko Majetić, Damir Ciglar, Josip Kasać, Goran Augustin, Tomislav Bruketa, Tin Ehrenfreund, Nenad Ferdelji, Miho Klaić, Danko Brezak, Zoran Domitran, Tomislav Staroveški, ]]></team_members_names><keywords_hr><![CDATA[bušenje, koštano-zglobna kirurgija, termička osteonekroza, nadzor, upravljanje, protočno hlađenje, automatizirana obrada, računalna inteligencija]]></keywords_hr><keywords_en><![CDATA[Drilling, Bone and joint surgery, Thermal osteonecrosis, Monitoring, Control, Internally cooled tool, Automated machining, Computational intelligence]]></keywords_en><summary_hr><![CDATA[Današnji sustavi medicinskog bušenja s primjenom u koštano-zglobnoj kirurgiji relativno su niskog stupnja automatizacije bez mogućnosti nadzora obradnog procesa i/ili adaptivnog upravljanja parametrima obrade u cilju sprječavanja mehaničkih i termičkih oštećenja koštanog tkiva. S druge strane, na pojavu termičke osteonekroze značajno utječe i primjena medicinskih svrdla bez mogućnosti protočnog hlađenja. Pritom se hlađenje često obavlja zalijevanjem površine kosti i tijela svrdla izvan kosti tijekom obrade što ima vrlo ograničeni efekt uslijed odvojenih čestica koje sprječavaju kontakt rashladnog sredstva s oštricama svrdla i činjenice da kost ima relativno nisku toplinsku vodljivost. Stoga je u okviru ovog projekta predložen niz aktivnosti koje bi trebale rezultirati razvojem novih sustava s perspektivom implementacije u slijedećim generacijama ručnih bušilica. Njihove bi karakteristike trebale potencijalno omogućiti nadzor mehaničkih i toplinskih utjecaja na alat i kost primjenom različitih vrsta mjernih sustava i naprednih algoritama odlučivanja, eksploataciju protočno hlađenih svrdla visokog učinka hlađenja, automatizaciju posmičnog gibanja alata uz potencijalnu primjenu visokobrzinskih režima obrade, te primjenu naprednih adaptivnih upravljačkih algoritama u cilju ograničenja sila i temperature rezanja. Realizacija postavljenih ciljeva omogućila bi prelazak iz područja potpuno ručnog bušenja u polu-automatizirani pristup u kojem bi operater ručno određivao samo mjesto bušenja i smjer/kut alata s obzirom na kost dok bi se preostale aktivnosti procesa odvijale autonomno korištenjem upravljačkog sustava stroja.]]></summary_hr><summary_en><![CDATA[Modern medical drilling systems used in bone and joint surgery are characterized with relatively low level of automation, i.e., with no process monitoring and/or adaptive control characteristics, which would prevent mechanical and thermal bone damages. On the other hand, application of classic medical drills with no internal cooling capabilities significantly influence on the occurrence of thermal osteonecrosis. Cooling is usually performed by applying cooling fluid externally on the bone surface and the part of tool not in the bone during the drilling process. This approach has very limited effect on the temperature reduction because bone debris prevent contact of cooling fluid with tool cutting edges, and bone itself has very low thermal conductivity. Therefore, a group of activities have been proposed by this project focused on the development of new systems with the implementation perspective in the next generation of hand-held drilling machines. Their characteristics should potentially ensure on-line monitoring of the mechanical and thermal effects on the tool and bone using different types of sensors and advanced decision algorithms, exploitation of highly effective internally cooled medical drills, automated tool feed movement with potential implementation of high-speed drilling regimes, as well as the application of advanced adaptive control algorithms for cutting forces and drilling temperature limitation. Implementation of those features would ensure transition from completely hand-controlled drilling machines to semi-automatic systems, where only drilling location and desired tool direction/angle should be defined by the surgeon, while all other activities would be performed autonomously by the machine monitoring and control system.]]></summary_en></project><project>
<id>3489</id><title_hr><![CDATA[Razvoj numeričkih modela armirano-betonskih i kamenih zidanih konstrukcija izloženih potresnom opterećenju zasnovanih na diskretnim pukotinama]]></title_hr><title_en><![CDATA[Development of numerical models for reinforced-concrete and stone masonry structures under seismic loading based on discrete cracks]]></title_en><user_id>5683</user_id><user_firstLast_name>Željana Nikolić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2014-09</proposal_call><code>IP-2014-09-2319</code><acronim><![CDATA[SeismoNuMod]]></acronim><duration>01.09.2015 - 30.09.2019</duration><status>Završio</status><financ_value>119.769,06 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Građevinarstvo, Temeljne tehničke znanosti, </scie_field_hr><scie_field_en>Civil engineering, Basic engineering sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Splitu Fakultet građevinarstva, arhitekture i geodezije]]></institution_hr><institution_en><![CDATA[University of Split, Faculty of Civil Engineering, Architecture and Geodesy]]></institution_en><team_members_id>13081, 5724, 5725, 12603, 13219, 12718, 13055, 13163, 13162, </team_members_id><team_members_names><![CDATA[Pavao Marović, Nikolina Živaljić, Hrvoje Smoljanović, Ivan Balić, Mijo Nikolić, Adnan Ibrahimbegovic, Lidija Krstevska, Mladen Glibić, Mladen Kustura, ]]></team_members_names><keywords_hr><![CDATA[Numeričko modeliranje,  Potresno djelovanje, AB konstrukcije, Kamene zidane konstrukcije, Diskretne pukotine]]></keywords_hr><keywords_en><![CDATA[Numerical modelling, Earthquake loading, RC structures, Stone masonry structures, Discrete cracks]]></keywords_en><summary_hr><![CDATA[Pojava pukotina je jedan od dominantnih uzroka nelinearnosti u krtim i kvazi-konstrukcijama koja dovodi do pojave lokaliziranog sloma i predstavlja ozbiljan izazov u numeričkom modeliranju. Proces nastanka pukotina započinje na mikrorazini, a progresivnim srastanjem stvaraju se makropukotine koje predstavljaju diskontinuitet u materijalu. Precizno modeliranje otvaranja i zatvaranja pukotina jedan je od ključnih čimbenika koji utječe na pouzdanost modela za analizu konstrukcija, posebno onih izloženih potresnom opterećenju. Sofisticirani numerički modeli temeljeni na metodi odgovora u vremenu i inkrementalnoj dinamičkoj analizi imaju značajnu ulogu u simulaciji ponašanja takvih konstrukcija prije i poslije sloma. U ovom projektu planira se razvoj dvaju nelinearnih modela za inkrementalnu dinamičku analizu konstrukcija zasnovanih na diskretnim pukotinama s različitim pristupima u rješavanju ovog problema. Jedan će biti novi 3D model za potresno opterećene armirano-betonske i kamene zidane konstrukcije ojačane trnovima i klamfama, zasnovan na metodi kombiniranih konačno-diskretnih elemenata kod koje pukotine nastaju u kontaktnim elementima smještenima duž rubova konačnih elemenata. Model će omogućiti raspucavanje, dinamičku interakciju razdvojenih elementa i praćenje ponašanja konstrukcije prije i nakon sloma. Drugi model će biti zasnovan na metodi konačnih elementa s ugrađenim diskontinuitetom i ugrađenom armaturom koja omogućuje nastanak pukotina neovisno o mreži konačnih elemenata i primijenit će se na armirano-betonske konstrukcije. Validacija razvijenih modela će se provesti usporedbom s dostupnim rezultatima eksperimentalnih istraživanja, dok se u svrhu validacije modela za kamene zidane konstrukcije planiraju provesti vlastiti eksperimenti na potresnoj platformi. Na kraju će se provesti usporedne analize ponašanja konstrukcija s oba modela.]]></summary_hr><summary_en><![CDATA[Crack opening is one of the dominant causes of nonlinearity in brittle and quasi-brittle structures which leads to localized failure and stands out as a serious challenge in numerical modelling. The process of crack initiation starts at a micro-scale, and with progressive growth, micro-cracks coalesce into macro-cracks representing discontinuities in the material. Therefore, a realistic modelling of crack initiation and propagation is one of the key factors that affect the reliability of the model for analysing the structures, especially those subjected to earthquakes. Sophisticated numerical models based on time dependent and incremental dynamic analysis can play an important role in simulating the behaviour of such structures before and after collapse. This project aims to develop two nonlinear numerical models for incremental dynamic analysis of structures based on the model of discrete cracks. The first one will be a novel 3D model for reinforced concrete and stone masonry structures strengthened with clamps and bolts based on the combined finite discrete element method where the cracks are modelled through the contact elements implemented between finite elements. The model enables crack initiation and propagation, dynamic interaction of separate elements and monitoring of structural behaviour before and after the collapse. The second model will be based on the finite element method with embedded discontinuity and embedded reinforcement, which allows for crack initiation and propagation independent of finite element mesh and will be applied to reinforced concrete structures. The novel numerical models for reinforced concrete structures will be validated by available experimental research, while our own experiments are planned to be performed at shaking table for the validation of stone masonry structure model. Thereafter, the comparative analysis of the behaviour of real structures with both models will be conducted.]]></summary_en></project><project>
<id>3491</id><title_hr><![CDATA[Karakterizacija preuređivanja endosomalnih membrana tijekom rane faze infekcije mišjim citomegalovirusom koje vodi k formiranju kompleksa za stvaranje viriona]]></title_hr><title_en><![CDATA[Characterization of endosomal remodelling during the early phase of murine cytomegalovirus infection that leads to the development of the assembly complex]]></title_en><user_id>6604</user_id><user_firstLast_name>Pero Lučin</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2014-09</proposal_call><code>IP-2014-09-9564</code><acronim><![CDATA[AsCo]]></acronim><duration>01.09.2015 - 31.08.2019</duration><status>Završio</status><financ_value>105.731,77 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Medicine]]></institution_en><team_members_id>6883, 6891, 6187, 6963, 21237, 21236, </team_members_id><team_members_names><![CDATA[Hana  Mahmutefendić, Gordana Blagojević Zagorac, Kristina Grabušić, Ljerka Karleuša, Marina Marcelic, Silvija Lukanović Jurić, ]]></team_members_names><keywords_hr><![CDATA[citomegalovirus, endosomi, preuređivanje endosoma, sklapanje viriona, fosfoinositidi]]></keywords_hr><keywords_en><![CDATA[Cytomegalovirus, endosomes, endosomal remodeling, virion assembly, phosphoinositides]]></keywords_en><summary_hr><![CDATA[Infekcija beta-herpesvirusima izaziva opsežnu reorganiziraju unutarstaničnih odjeljka u svrhu stvaranja okruženja za stvaranje virusa, poznatog kao kompleks za stvaranje virusa (AC, engl. assembly complex). Ova struktura razvija se postupno, počevši od najranijih stadija infekcije, i uključuje stupnjevitu reorganizaciju membranskih organela. Iako je sastav i organizacija AC relativno dobro karakterizirana tijekom infekcije humanim citomegalovirusom (CMV), dio događanja koji vodi razvoju AC-a je slabo poznat. Cilj ovoga projekta je karakterizirati procese koji prethode stvaranju AC-a u stanicama inficiranim mišjim CMV-om (MCMV). MCMV započinje remodeliranje endosomalnog sustava vrlo rano tijekom infekcije, što smo karakterizirali kao razvoj endosomalnog retencijskog odjeljka rane faze (EPERC). Postoji jaka indikacija da je upravo EPERC prethodnih AC-a. Općenito je prihvaćeno da je remodeliranje endosomalnog sustava posredovano malim GTPazama iz Rab i Arf obitelji te fosfoinozitidima.  U predloženom projektu cilj nam je razotkriti procese reorganizacije membranskih organela tijekom rane faze infekcije, koji dovode do stvaranja AC-a. U tu svrhu utvrditi ćemo ulogu malih ATPaza iz obitelji Rab i Arf te njihovih efektorskih proteina tijekom stvaranja EPERC. Naposljetku, karakterizirati ćemo membranske domene EPERC-a tijekom rane faze infekcije obzirom na sastav fosfoinositida. To će uključivati proučavanje endosomalnih efektorskih proteina koji se vezuju na fosfoinositide i glavnih endosomalnih enzima koji nadziru konverziju fosfoinositida i tako mijenjaju osobine membrana. Kako bismo postigli navedene ciljeve koristiti ćemo trostruko imunofluorescencijsko bojanje EPERC-a, fluorescentne boje stvorene genetičkim inženjeringom, utišavanje RNA i farmakološke inhibitore. Konačni ishod predloženog istraživanja biti će rekonstrukcija mehanizma razvoja EPERC-a i identifikacija staničnih proteina koji predstavljaju mjesto djelovanja MCMV-a tijekom rane faze infekcije.]]></summary_hr><summary_en><![CDATA[Beta-herpesviruses massively reorganize the intracellular compartments in order to create an environment for virion production, known as assembly complex (AC). This structure develops gradually from the earliest stages of infection and involves stepwise reorganization of membrane organelles. Although the final structure is relatively well characterized during human cytomegalovirus infection, the sequence of events that leads to the development of the AC is poorly understood. The goal of this project is to characterize processes proceeding to the formation of the AC in cells infected with murine CMV (MCMV). MCMV starts with remodeling of the endosomal system very early in the infection, which we characterized as development of the early-phase endosomal retention compartment (EPERC). There is strong indication that the EPERC is predecessor of AC. It is generally accepted that endosomal remodeling is driven by small GTPases from the Rab and Arf family and phosphoinositides (PI). In the proposed project, we plan to reveal sequence of membranous organelle reorganization events in the early phase of infection that presumably lead to the formation of the AC. With that purpose, we will determine the role of small GTPases of the Rab and Arf family and their effector proteins in membrane organelle perturbation events during the early phase of MCMV infection. Finally, we plan to characterize membrane domains of the EPERC during the entire early phase regarding PI content, which include the study of PI effectors and major enzymes that drive PI conversion and thereby change membrane identity. To achieve these goals, we will use triple immunofluorescence staining of EPERC, genetically engineered fluorescent probes, RNA silencing and pharmacological inhibitors. Outcome of the proposed research will be a reconstruction of the mechanism of development of the EPERC and identification of cellular proteins that are targeted by MCMV in the early phase of infection.]]></summary_en></project><project>
<id>3492</id><title_hr><![CDATA[Energetski učinkovit asinkroni bežični prijenos]]></title_hr><title_en><![CDATA[Energy efficient asynchronous wireless transmission]]></title_en><user_id>6379</user_id><user_firstLast_name>Tomislav Matić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2014-09</proposal_call><code>UIP-2014-09-6219</code><acronim><![CDATA[EEAWT]]></acronim><duration>01.09.2015 - 31.12.2018</duration><status>Završio</status><financ_value>105.904,60 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Elektrotehnika, </scie_field_hr><scie_field_en>Electrical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište Josipa Jurja Strossmayera Osijek, Fakultet elektrotehnike, računarstva i informacijskih tehnologija Osijek]]></institution_hr><institution_en><![CDATA[Josip Juraj Strossmayer University of Osijek, Faculty of Electrical Engineering, Computer Science and Information Technology Osijek]]></institution_en><team_members_id>6386, 6383, 6454, 6349, 7056, 5092, 13651, 13497, </team_members_id><team_members_names><![CDATA[Marijan Herceg, Tomislav Švedek, Mario Vranješ, Ratko Grbić, Denis Vranješ, Denis Pelin, Josip Job, Leon Šneler, ]]></team_members_names><keywords_hr><![CDATA[bežični prijenos, asinkrona analogno-digitalna pretvorba, ultra-širokopojasni modulacijski postupci, bežične senzorske mreže, internet objekata]]></keywords_hr><keywords_en><![CDATA[wireless transmission, asynchronous analog-to-digital conversion, ultra-wideband modulation techniques, wireless sensor networks, internet of things]]></keywords_en><summary_hr><![CDATA[Kako bi se postigla energetska učinkovitost i smanjila površina integriranih sklopova za bežični prijenos, u posljednje se vrijeme primjenjuju asinkroni dizajn i širokopojasni modulacijski postupci. Veliki izazov pri projektiranju asinkronog bežičnog prijenosa je detekcija signala na strani prijemnika i uspostava više-korisničkog prijenosa. Prijedlog istraživačkih aktivnosti u sklopu ovog projekta je izrada energetski učinkovitih asinkronih integriranih sklopova za bežični prijenos analognog signala primjenjivih u senzorskim čvorovima bežičnih senzorskih mreža. Predloženi sustav se može podijeliti na dva podsustava, analogno-digitalni pretvornik i modulator za bežični prijenos. Na taj se način projektne aktivnosti mogu podijeliti u dvije faze. Prva faza uključuje izradu asinkronog analogno-digitalnog pretvornika, dok druga faza uključuje aktivnosti u izradi modulatora temeljenog na ultra-širokopojasnom (UWB) generatoru impulsa. Za izradu analogno-digitalnog pretvornika primjenjivat će se asinkroni sigma-delta modulator i različite tehnike temeljene na detekciji razine signala, dok će se za izradu UWB modulatora razmatrati modulacijske tehnike za digitalne ulazne signale. Zbog jako uskog impulsa i načina rada s iznimno niskim faktorom ispune, UWB modulacijski postupci su atraktivan izbor za energetski učinkovit bežični prijenos. Razvoj postojećih i izrada novih širokopojasnih modulacijskih postupaka u sklopu ovog projekta provodit će se s ciljem postizanja energetske učinkovitosti. Kako bi se zadovoljili osnovni ciljevi energetske i površinske učinkovitosti, prijenosni sustav će biti izrađen u CMOS procesu.]]></summary_hr><summary_en><![CDATA[To achieve high circuit power and size efficiency in wireless transmission circuits, recent contributions propose asynchronous design and spread spectrum communications. A great challenge in asynchronous wireless transmission is to accomplish signal detection at the receiver side and to establish multiuser transmission. The proposal of research activities in this project will be the design of low power asynchronous circuits for wireless transmission of analog input signals applicable as sensor nodes in short distance wireless sensor networks. The proposed system can be divided into two major subsystems consisting of the analog-to-digital (A/D) converter and the modulator for wireless transmission. Hence, the project activities can be divided into two major phases. The first phase will include asynchronous ADC design, where novel circuit architectures will be investigated, while the second phase will include activities on the modulator design incorporating ultra-wideband (UWB) pulse generators. The asynchronous sigma-delta modulator and various level crossing schemes will be investigated for A/D conversion, while UWB modulation techniques will be considered for the digitized signal modulation. Due to narrow pulse width and duty-cycled operation, UWB modulation techniques are a reasonable choice for the energy efficient wireless transmission. Evaluation of existing and development of new spread spectrum modulation techniques will be carried out to improve energy efficiency. To satisfy the major size and power consumption requirements, the transmission circuitry will be designed in CMOS process.]]></summary_en></project><project>
<id>3494</id><title_hr><![CDATA[Društvena stratifikacija u Hrvatskoj: strukturni i subjektivni aspekti]]></title_hr><title_en><![CDATA[Social stratification in Croatia: structural and subjective aspects]]></title_en><user_id>13642</user_id><user_firstLast_name>Karin Doolan</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2014-09</proposal_call><code>UIP-2014-09-3134</code><acronim><![CDATA[STRAT]]></acronim><duration>01.07.2016 - 19.12.2020</duration><status>Završio</status><financ_value>63.335,32 eur</financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Sociologija, </scie_field_hr><scie_field_en>Sociology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zadru]]></institution_hr><institution_en><![CDATA[University of Zadar]]></institution_en><team_members_id>13306, 13384, 13296, 12672, 13241, 21265, 11230, 21272, 4944, 20316, 21073, </team_members_id><team_members_names><![CDATA[Valerija Barada, Branko Ančić, Sven Marcelić, Mladen  Domazet, Krešimir Krolo, Ivana Jugović, Jaka Primorac, Petra Rodik, Željka Tonković, Drago Župarić-Iljić, Drazen Cepic, ]]></team_members_names><keywords_hr><![CDATA[stratifikacija, klase, Bourdieu, nejednakosti, mješovite metode]]></keywords_hr><keywords_en><![CDATA[stratification, class, Bourdieu, inequalities, mixed methods ]]></keywords_en><summary_hr><![CDATA[Cilj predloženoga projekta je oživjeti klasnu analizu u Hrvatskoj budući da u Hrvatskoj od kasnih 1980-ih postoji praznina na tom važnom istraživačkom polju. U sociološkoj tradiciji, “skliski” koncept “klase” koristi se kako bi se teoretiziralo i istraživalo društvene nejednakosti. Pridjev “sklizak” u ovom se kontekstu upotrebljava kako bi označio tekuće rasprave o tome je li klasa i dalje relevantan analitički koncept, kao i rasprave oko različitih tradicija konceptualiziranja klase. Suprotstavljeni suvremeni pristupi klasi kreću se od neomarksističkih i neoveberijanskih pristupa u klasnoj analizi do ponovnog oživljavanja Bourdieuova klasnog modela, te primjerice istraživanja “duševne ekonomije klase”. Pristup analizi društvenih klasa iznesen u ovome projektu nadahnut je Bourdieuovim radom na temu društvenih nejednakosti. Bourdieuova (1992) klasna analiza sastoji se od dvaju “trenutaka”: konstruiranja objektivnih struktura identificiranjem distribucije resursa (kulturnih, ekonomskih, društvenih) koji čine ograničenja djelovanju, te procesa kojima se ta ograničenja (iznova) stvaraju. Drugim riječima, fokus je na utvrđivanju “objektivnih” klasnih pozicija, kao i na tomu kako se one manifestiraju u rutinskim aktivnostima, a taj je pristup preuzet i u ovome projektu. Podaci iz upitnika vezani uz ekonomski, kulturni i društveni kapital ljudi prikupljat će se na nacionalno reprezentativnom uzorku  stanovnika Hrvatske, i na temelju toga razvit će se klasni model hrvatskoga društva. Osim toga, provest će se i 120 narativnih intervjua kojima će se zabilježiti životne priče ciljno odabranog uzorka muškaraca i žena koji žive u različitim hrvatskim regijama i imaju različite klasne pozicije. Svrha tih razgovora je istražiti biografsko djelovanje klasa, u smislu poimanja samoga sebe, svakodnevnih praksi te u kriznim vremenima. Predloženi nacrt mješovitih metoda istraživanja omogućit će istraživanje kako strukturnih tako i subjektivnih vidova društvene stratifikacije. ]]></summary_hr><summary_en><![CDATA[The objective of this proposed project is to revive class analysis in Croatia since there has been a gap in this important research field in Croatia since the late 1980s. In the sociological tradition, the “slippery” concept of “class” has been used to theorise and research social inequalities. The adjective “slippery” is used to signal running debates on whether class is still a viable analytical concept, as well as debates surrounding diverse traditions of conceptualising class. Contemporary debates range from neo-Marxist and neo-Weberian perspectives to revitalised versions of Bourdieu’s class model, as well as more micro-level approaches in class analysis including research on the “psychic economy of class”. This project is inspired by Bourdieu’s work on social inequalities. Bourdieu’s (1992) class analysis consists of two “moments”: the construction of objective structures by identifying the distribution of resources (cultural, economic, social) that act as external constraints bearing on practices and the exploration of how people subjectively (re)create these structures. In other words, there is a focus on identifying “objective” class locations, as well as how these locations are practised in routine activities; this is the approach taken up by this project. Questionnaire data on people’s economic, cultural and social capital will be collected from a nationally representative sample of people living in Croatia, on the basis of which a class model of Croatian society will be developed. In addition, 120 life story interviews with a purposive sample of women and men living in different regions of Croatia and occupying different class locations will be conducted. The purpose of the interviews is to explore how class works biographically, both in terms of self-identification, everyday practices and at times of crisis. The mixed methods approach will enable the exploration of both structural and subjective aspects of social stratification. ]]></summary_en></project><project>
<id>3495</id><title_hr><![CDATA[Kooperativno upravljanje iskustvenom kvalitetom u pokretnim mrežama za interaktivne višemedijske aplikacije u računalom oblaku]]></title_hr><title_en><![CDATA[Cooperative Quality of Experience Management for Interactive Cloud-Based Multimedia Applications in Mobile Networks]]></title_en><user_id>3964</user_id><user_firstLast_name>Lea Skorin-Kapov</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2014-09</proposal_call><code>UIP-2014-09-5605</code><acronim><![CDATA[Q-MANIC]]></acronim><duration>01.07.2015 - 30.06.2018</duration><status>Završio</status><financ_value>64.503,28 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Računarstvo, Elektrotehnika, </scie_field_hr><scie_field_en>Computer sciences, Electrical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id>932, 13031, 4451, 6269, 6704, 2775, 21062, </team_members_id><team_members_names><![CDATA[Maja Matijašević, Martín Varela, Aleksandra Čereković, Ivan Slivar, Dunja  Vučić, Mirko Sužnjević, Irena Oršolić, ]]></team_members_names><keywords_hr><![CDATA[Iskustvena kvaliteta, modeliranje iskustvene kvalitete, višemedijske aplikacije, računalni oblak, upravljanje iskustvenom kvalitetom]]></keywords_hr><keywords_en><![CDATA[Quality of Experience, QoE modelling, multimedia applications, cloud, QoE management]]></keywords_en><summary_hr><![CDATA[Zbog rasta broja novih pokretnih uređaja poput pametnih telefona i tableta, aplikacije i usluge namijenjene izvođenju na pokretnim uređajima su postale sastavni dio ljudske svakodnevice, sa značajnim utjecajem na ljudsku komunikaciju, učenje i zabavu. Potaknut zahtjevima poput skalabilnosti, fleksibilnosti i administracije, nastavio se trend migracije aplikacija u računalni oblak. Ono što i dalje ostaje ključni problem i razlikovno sredstvo između pružatelja usluga je ispunjavanje zahtjeva krajnjih korisnika s obzirom na očekivanu kvalitetu usluge, a što se naziva iskustvenom kvalitetom (QoE). Projekt Q-MANIC predložit će kooperativnu shemu za upravljanje iskustvenom kvalitetom, iskorištavajući nova znanja o iskustvenoj kvaliteti i poslovne modele usredotočene na kooperativne napore pružatelja usluga/usluga zasnovanih na računalnom oblaku i davatelja usluga u pokretnim mrežama kako bi se ostvarilo efikasnije upravljanje mrežnim resursima, a pritom i poboljšala iskustvena kvaliteta krajnjeg korisnika. Pored postojećih načina razmjene informacija u današnjim mrežama, bit će predloženi novi pristupi za koordinaciju i razmjenu informacija između aktora u postojećem vrijednosnom lancu pružatelja usluga. Bit će predloženi novi načini raspodjele resursa i novi algoritmi za prilagodbu usluge koji imaju u vidu različite strategije optimizacije. Kako bi pokazali korist i primjenjivost predloženog pristupa, prikazat ćemo dva slučaja uporabe koji predstavljaju primjer visoko interaktivnih i mrežno zahtjevnih višemedijskih aplikacija koje su dostavljaju putem pokretnih mreža (LTE/LTE-advanced/5G): usluga igranja u pokretu zasnovana na računalnom oblaku i usluga višekorisničkog video razgovora u pokretu. Oslonit ćemo se empirijski dobivene podatke kako bi specificirali modele iskustvene kvalitete i optimalne strategije za prilagodbu usluge. Shema za upravljanje iskustvenom kvalitetom koristit će mehanizme za upravljanje mrežom i strategije za prilagodbu aplikacije kako bi se poboljšala iskustvena kvaliteta i povećala efikasnost zauzeća resursa. Ključni doprinos bit će ugradnja kontekstualnih znanja i rezultata analize korisničkog ponašanja i interakcije u validirani model iskustvene kvalitete koji će biti korišten za efikasno upravljanje iskustvenom kvalitetom.]]></summary_hr><summary_en><![CDATA[With the proliferation of new mobile devices such as smartphones and tablets, mobile applications have become an integral part of our daily life activities, with a profound impact on the way people communicate, learn, or entertain. Driven by requirements such as scalability, flexibility, and administration, there is an increasing trend in migrating applications to the cloud. A key concern and differentiator between providers is meeting end users’ requirements in terms of service quality and expectations, referred to as Quality of Experience (QoE). The Q-MANIC project will propose a cooperative QoE management scheme exploiting new QoE knowledge and business models based on cooperative efforts between cloud/service providers and mobile network operators to achieve more efficient management of network/system resources, while enhancing end user QoE. Novel approaches for coordination and information exchange among actors involved in the service delivery chain will be proposed beyond those available in today&#39;s networks. Resource allocation and service adaptation algorithms will be proposed targeting different optimization strategies and taking into account multiple stakeholder perspectives. To demonstrate the benefits and applicability of the proposed approach, we address two use cases involving interactive, bandwidth intensive cloud-based applications delivered via mobile networks (LTE/LTE-advanced/5G): mobile cloud gaming and mobile multi-party video chat. We will rely on empirically obtained data to specify QoE models and optimal service adaptation strategies. The QoE management scheme will combine network management mechanisms and application adaptation strategies to bring improvements in QoE and efficiency of resource usage. A key contribution will be the incorporation of contextual knowledge and analysis of user behaviour and interactions into building validated QoE models that will be exploited in the context of QoE management.]]></summary_en></project><project>
<id>3501</id><title_hr><![CDATA[Ispitivanje reaktivnosti trombocita u različitim srčanožilnim bolestima]]></title_hr><title_en><![CDATA[Studies on PlAtelet REactivity Levels In difFErent CardioVascular Diseases]]></title_en><user_id>7462</user_id><user_firstLast_name>Davor  Miličić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2014-09</proposal_call><code>IP-2014-09-8403</code><acronim><![CDATA[SPARELIFE-CVD]]></acronim><duration>01.12.2015 - 30.11.2019</duration><status>Završio</status><financ_value>130.731,97 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Kliničke medicinske znanosti, </scie_field_hr><scie_field_en>Clinical sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb School of Medicine]]></institution_en><team_members_id>1021, 3349, 5362, 7354, 7483, 7201, 7352, 13689, 7344, 4638, 7185, 4641, 12324, 985, 7313, 24919, 26203, </team_members_id><team_members_names><![CDATA[Boško Skorić, Maja Čikeš, Jure Samardžić, Miroslav Krpan, Jana Ljubas Maček, Željko Baričević, Marijan Pašalić, Hrvoje Jurin, Ivo Planinc, Bojan Biočina, Hrvoje  Gašparović, Mate Petričević, Davor Puljevic, Joško Bulum, Vedran Velagic, Zvonimir Ostojić, Dubravka Šipuš, ]]></team_members_names><keywords_hr><![CDATA[kardiovaskularne bolesti, reaktivnost trombocita, agregometrija, personalizirana kardiologija, klinički ishodi]]></keywords_hr><keywords_en><![CDATA[cardiovascular diseases, platelet reactivity, aggregometry, personalized cardiology, clinical outcomes]]></keywords_en><summary_hr><![CDATA[Predloženi projekt je nastavak dosadašnjeg rada u kojem se nastoji ispitati značaj reaktivnosti trombocita u različitim srčanožilnim oboljenjima te mogućnost da se individualiziranom primjenom antitrombocitnih lijekova prema vrijednostima reaktivnosti trombocita poboljšaju klinički ishodi. Istraživanje je podijeljeno u pet cjelina koje će se paralelno provoditi. Prva cjelina obuhvaća nastavak istraživanja utjecaja povišene ostatne reaktivnosti trombocita i individualiziranog pristupa primjene antitrombocitne terapije u bolesnika s akutnim koronarnim sindromom. Druga cjelina će istraživati promjene reaktivnosti trombocita kod bolesnika nakon izvanbolničkog aresta koji se podvrgavaju protokolu terapijske hipotermije. Nedovoljno je istraženo kako kontrolirano snižena tjelesna temperatura utječe na agregacijsku kaskadu in vivo, osobito u bolesnika koji se liječe antitrombocitnim lijekovima. Treća cjelina će obuhvatiti bolesnike koji se liječe mehaničkom cirkulacijskom potporom zbog terminalne faze srčanog popuštanja. U toj skupini evaluirat ćemo reaktivnost trombocita povezanu s korištenjem izvantjelesnog krvotoka odnosno mehaničkih srčanih crpki i povezanost s trombozama uređaja i s krvarenjima. U četvrtoj cjelini istraživat ćemo ulogu funkcije trombocita u sekundarnoj plućnoj hipertenziji uzrokovanoj bolešću miokarda lijeve klijetke (WHO tip II). Povezanost reaktivnosti trombocita i težine bolesti je već pokazana u primarnoj plućnoj hipertenziji, ali ne i u mnogo češćoj, plućnoj hipertenziji tipa II. Rezultati bi mogli pridonijeti poznavanju patofiziologije sekundarne plućne hipertenzije tipa II s mogućim terapijskim implikacijama, jer se namjerava ispitati, moduliraju li promjene reaktivnosti trombocita vazoaktivni odgovor na prostaglandin E1. Posljednja, peta cjelina će biti posvećena ispitivanju prognostičkog značenja reaktivnosti trombocita na razvoj koronarne vaskulopatije u bolesnika nakon presadbe srca što do sada nije istraživano.]]></summary_hr><summary_en><![CDATA[The proposed project represents a continuation of our previous work which will examine the significance of platelet reactivity (PR) in a variety of cardiovascular diseases and the potential of individualized approach in antiplatelet therapy regimen based on the values of PR to improve clinical outcomes. The research will be divided into five arms that will be conducted simultaneously. The first arm will be the continuation of our research on the impact of high on-treatment platelet reactivity and individualized approach to the application of antiplatelet therapy in patients with acute coronary syndrome. The second arm will study the changes of PR in patients with out-of-hospital cardiac arrest who undergo therapeutic hypothermia protocol. It is insufficiently explored how a controlled low body temperature affects the aggregation cascade in vivo, particularly in patients treated with antiplatelet drugs. The third arm will include patients with implanted mechanical circulatory support (MCS) due to end-stage heart failure. In this group we will evaluate the association of PR levels in patients with MCS and device thromboses as well as bleeding events. In the fourth study arm we will investigate the role of platelet function in secondary pulmonary hypertension caused by left ventricular myocardial disease (WHO type II). Correlation between PR and the severity of the disease has been shown in primary pulmonary hypertension, but not in much more frequent, type II pulmonary hypertension. The results might contribute to the knowledge of the pathophysiology of pulmonary hypertension, with potential therapeutic implications as we intend to examine whether the changes in PR modulate the response to vasoactive prostaglandin E1. The last, fifth arm will be devoted to heart transplant patients where we will examine the prognostic significance of PR in the development of coronary vasculopathy after heart transplantation which has not been investigated so far.]]></summary_en></project><project>
<id>3515</id><title_hr><![CDATA[Razvoj biokompatibilnih materijala na temelju hidroksiapatita za primjene u inženjerstvu koštanog tkiva ]]></title_hr><title_en><![CDATA[Development of Biocompatible Hydroxyapatite Based Materials for Bone Tissue Engineering Applications]]></title_en><user_id>12662</user_id><user_firstLast_name>Hrvoje  Ivanković</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2014-09</proposal_call><code>IP-2014-09-3752</code><acronim><![CDATA[HATEA]]></acronim><duration>01.03.2017 - 28.02.2021</duration><status>Završio</status><financ_value>131.772,65 eur</financ_value><scie_area_hr>Tehničke znanosti, Biomedicina i zdravstvo, Prirodne znanosti, Biotehničke znanosti, </scie_area_hr><scie_area_en>Technological sciences, Biomedicine and health sciences, Natural sciences, Biotechnical sciences, </scie_area_en><scie_field_hr>Kemijsko inženjerstvo, Kemija, Biologija, Strojarstvo, Temeljne tehničke znanosti, Kliničke medicinske znanosti, Veterinarska medicina, Biotehnologija, Biotehnologija u biomedicini, </scie_field_hr><scie_field_en>Chemical engineering, Chemistry, Biology, Mechnical engineering, Basic engineering sciences, Clinical sciences, Veterinary medicine, Biotechnology, Biotechnology in Biomedicine, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet kemijskog inženjerstva i tehnologije]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Chemical Engineering and Technology]]></institution_en><team_members_id>13014, 12343, 12661, 12336, 13487, 6475, 12976, 12334, 13266, 13408, 22929, 12914, 22646, 6099, </team_members_id><team_members_names><![CDATA[Marica  Ivanković, Dajana Milovac, Anamarija Rogina, Sebastijan Orlić, Gloria Gallego-Ferrer, Zdenka Keran, Petar Piljek, Dragana Gabrić Pandurić, Elizabeta Gjorgievska, Damir Mihelić, Antonia  Ressler, Klaudia Paljar, Leonard Bauer, Maja Antunović, ]]></team_members_names><keywords_hr><![CDATA[inženjerstvo koštanog tkiva, skelet, hidroksiapatit, biorazgradivi polimeri, in vitro/vivo ponašanje]]></keywords_hr><keywords_en><![CDATA[bone tissue engineering, scaffold, hydroxyapatite, biodegradable polymers, in vitro/vivo behaviour]]></keywords_en><summary_hr><![CDATA[Izazov za inženjerstvo koštanog tkiva je razvoj odgovarajućih skeleta (engl. scaffold) koji omogućavaju dobru integraciju s okolnim tkivom. Posljednjih godina intenzivno se istražuje hidroksiapatit (HAp) zbog njegove kemijske i strukturne sličnosti s anorganskom matricom prirodne kosti i odlične bioaktivnosti. Nedostatak HAp-a su njegova slaba mehanička svojstva pa se obično kombinira s polimerima i metalima. U prethodnim istraživanjima pripravili smo visoko porozne skelete na temelju HAp-a i poli(?-kaprolakton)-a (PCL) korištenjem jednostavnih i ekonomičnih postupaka. In vitro istraživanja sa stanicama MC3T3-E1 pokazala su da skeleti nisu toksični i da su odgovarajuća 3D podloga za prianjanje, umnažanje i diferenciranje stanica. Provedene su i preliminarne sinteze poroznih skeleta na temelju HAp-a i kitozana. Dobiveni su vrlo obećavajući rezultati uzimajući u obzir poroznost i međusobnu povezanost pora te netoksičnost materijala.Opći cilj ovog projekta je poboljšanje mehaničkih i bioloških svojstava biokompatibilnih materijala na temelju hidroksiaptita, posebice njihove sposobnosti poticanja aktivnog stvaranja kosti. Specifični ciljevi projekta su:  (1) sustavno istražiti utjecaj vrste i količine iona elemenata u tragovima (Mn, Si, Zn, Cu..) na biološko ponašanje skeleta;  (2) istražiti ponašanje skeleta in vivo, implantiranjem odabranih skeleta u oštećenja potkoljenične kosti kunića; (3) istražiti mogućnosti kanalnog kutnog prešanja za dobivanje novih HAp/titan kompozita za primjene u inženjerstvu koštanog tkiva.  Čvrsto vjerujemo da će projekt doprinijeti boljem razumijevanju sinteze, strukture i svojstava novih materijala za primjene u inženjerstvu koštanog tkiva. Razvoj novih skeleta na temelju HAp-a može imati pozitivne implikacije za društvo u smislu tretiranja i liječenja koštanih oštećenja te tako poboljšati kvalitetu života pacijenata, posebice starijih. Nadalje, ova istraživanja mogu otvoriti vrata novim primjenama skeleta u istraživanju matičnih stanica. ]]></summary_hr><summary_en><![CDATA[The challenge of bone tissue engineering (BTE) is to develop bone scaffolds that allow a good integration with the surrounding tissues. Particular systems of interest are scaffolds based on hydroxyapatite (HAp), due to its chemical and structural similarity to the inorganic matrix of natural bone and excellent bioactivity. To overcome disadvantages such as poor mechanical properties of HAp it has been combined with polymers and metals. In our previous studies highly porous HAp and poly(?-caprolactone),(PCL),- coated HAp scaffolds were prepared using simple and inexpensive methods. In vitro cell culture studies showed that scaffolds are nontoxic and provide an adequate 3D support for the attachment, proliferation and differentiation of MC3T3-E1 cells. Some preliminary studies on preparation of HAp/chitosan scaffolds showed promising results regarding porosity and interconnectivity of pores and nontoxicity.The overall objective of this project is to investigate methods to improve mechanical and biological properties of HAp-based materials especially the ability to propagate active bone formation. The specific objectives of the project are: (1) to investigate systematically the effect of dopants (Mn, Si, Zn, Cu..) on biological performance of the scaffolds (2) to assess in vivo biological performance of scaffolds by implanting the selected scaffolds in rabbits&#39; lower legs defects. (3) to investigate the potential of equal-channel angular pressing to produce novel HAp/titanium composites for BTE applications.We strongly beleive that the research will contribute to the better understanding of the synthesis, structure and properties of scaffolds for BTE applications. Development of novel HAp-based scaffolds could have positive implications for society in terms of treating and healing bone defects, improving quality of life for trauma patients and the elderly. Additionally, the research will open the door to new applications of scaffolds in stem cells research.]]></summary_en></project><project>
<id>3516</id><title_hr><![CDATA[Različiti učinci okolišno relevantnih mješavina metal temeljenih nanočestica i pesticida na faunu tla: Nove smjernice za procjenu rizika]]></title_hr><title_en><![CDATA[Diverse Effects of Environmentally Relevant Metal-based Nanoparticle and Pesticide Mixtures on Soil Fauna: A Novel Issue for Risk Assessment ]]></title_en><user_id>6027</user_id><user_firstLast_name>Branimir Hackenberger Kutuzović</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2014-09</proposal_call><code>IP-2014-09-4459</code><acronim><![CDATA[DEFENSoil]]></acronim><duration>02.11.2015 - 01.11.2019</duration><status>Završio</status><financ_value>107.173,67 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Biologija, </scie_field_hr><scie_field_en>Biology, </scie_field_en><institution_hr><![CDATA[Sveučilište Josipa Jurja Strossmayera u Osijeku, Odjel za biologiju]]></institution_hr><institution_en><![CDATA[Josip Juraj Strossmayer University of Osijek, Department of Biology]]></institution_en><team_members_id>6022, 6798, 5347, 5348, 5901, 25219, </team_members_id><team_members_names><![CDATA[Davorka Hackenberger Kutuzović, Sandra Ečimović, Mirna  Velki, Željka Lončarić, Goran Palijan, Marija Kovačević, ]]></team_members_names><keywords_hr><![CDATA[metal temeljene nanočestice, toksičnost mješavina, procjena okolišnog rizika, fauna tla, gujavice, ekotoksikologija]]></keywords_hr><keywords_en><![CDATA[metal based nanoparticles, mixture toxicity, environmental risk assessment, soil fauna, earthworm, ecotoxicology]]></keywords_en><summary_hr><![CDATA[Tlo je neobnovljivi prirodni resurs karakteriziran mnogobrojnim procesima koji se uvelike mijenjaju kao posljedica povećanog antropogenog pritiska na okoliš. Pravilno i stabilno funkcioniranje tla nužan je preduvjet održivosti terestričkih ekoloških sustava, te bitan čimbenik u planiranju ljudskih aktivnosti u smislu održivog razvoja. Među brojnim zagađivalima prisutnima u okolišu pesticidi se, zbog njihove široke i uobičajene upotrebe, te utjecaja na neciljne organizme, smatraju jednima od glavnih zagađivala tla. Nanočestice (NP) su u novije vrijeme dovedene u središte pozornosti zbog sve veće zastupljenosti u poljoprivredi što naglašava važnost razumijevanja njihovih ekotoksikoloških učinaka. Cilj projektnog prijedloga je određivanje različitih učinaka mješavina NP i pesticida na neciljnim organizmima u tlu. Kako bi ostvarili navedene ciljeve predlažemo sveobuhvatno  ekotoksikološko istraživanje koje uključuje različite razine složenosti (preliminarna laboratorijska-eksperimenti u ograničenim okolišnim uvjetima), različite krajnje točke (molekularna-populacijska razina), različite scenarije izlaganja (jedan toksikant–mješavina, kratko-dugačko izlaganje, jednostruko–niz izlaganja) i uključivanje modelnih i nativnih organizama tla. Na temelju složenih eksperimentalnih podataka o toksičnim učincima odabranih pesticida i NP, izraditi će se predikcijski model pogodan za optimizaciju biomonitoringa opterećenja tla, te matrični modeli učinaka na razini populacija ispitivanih organizama. Iz modela će se procijeniti učinci istraživanih toksikanata, te odrediti uvjeti pod kojima modelirana populacija pruža odgovor na aplicirane toksikante i mijenja svoj potencijal odgovora na druge stresore. Očekivani rezultati poboljšati će znanje o toksičnosti smjesa na neciljne organizme tla, te o mogućim utjecajima i ekotoksikološkim karakteristikama metal temeljenih NP što će biti primjenjivo u procesu procjene okolišnog rizika pogodnim za tehnološki suvremene načine korištenja tla. ]]></summary_hr><summary_en><![CDATA[Soil is a non-renewable resource subjected to a series of degradation processes and increasing environmental pressure, driven or exacerbated by human activity. As the appropriate functioning of the soil is essential for terrestrial ecosystems and human activity the risk of its impairment should be taken very seriously. Among numerous pollutants present in the environment, pesticides, due to their wide and common usage and impact on non-target organisms, represent one of the major soil pollutants. More recently nanoparticles (NPs) have been brought into focus as the increased interest for their usage in agriculture highlights the importance of understanding its ecotoxicological effects. The proposed project aims to identify the various effects of NPs and pesticides mixtures on non-targeted soil organisms, but also to identify the interactions of metal-based NPs and pesticides. In order to deliver the specified objectives of the project we propose a comprehensive ecotoxicological research which includes various levels of complexity (from preliminary laboratory to semi-field experiments), different endpoints (from molecular to population level), different exposure scenarios (single-mixture, short-long, single application-sequence of applications) and inclusion of both model and native soil organisms. Additionally, based on experimental data on toxic effects of selected pesticides and metal-based NPs, population-level matrix models will be constructed. From the model outputs the effects of investigated toxicants will be assessed and used to establish under which set of conditions a modelled population will respond to applied toxicants and alter its potential to respond to other stressors. The expected results will improve the state of knowledge on toxicity of mixtures on non-targeted soil organisms and can be implemented in risk assessment process. Consequently, expected results can enhance soil protection and soil ecological sustainability.]]></summary_en></project><project>
<id>3529</id><title_hr><![CDATA[Kohortna studija rođenih na istočnojadranskim otocima]]></title_hr><title_en><![CDATA[CRoatian Islands&#39; Birth cohort Study]]></title_en><user_id>3126</user_id><user_firstLast_name>Saša Missoni</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2014-09</proposal_call><code>UIP-2014-09-6598</code><acronim><![CDATA[CRIBS]]></acronim><duration>01.11.2015 - 31.10.2018</duration><status>Završio</status><financ_value>107.702,30 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo, Prirodne znanosti, Društvene znanosti, Humanističke znanosti, Biotehničke znanosti, </scie_area_hr><scie_area_en>Biomedicine and health sciences, Natural sciences, Social sciences, Humanities, Biotechnical sciences, </scie_area_en><scie_field_hr>Javno zdravstvo i zdravstvena zaštita, Biologija, Temeljne medicinske znanosti, Nutricionizam, Etnologija i antropologija, </scie_field_hr><scie_field_en>Public health and health services, Biology, Basic Medical Sciences, Nutrition, Ethnology and anthropology, </scie_field_en><institution_hr><![CDATA[Institut za antropologiju]]></institution_hr><institution_en><![CDATA[Institute for Anthropological Research]]></institution_en><team_members_id>828, 1509, 815, 804, 813, 6673, 4523, 5909, 1040, 994, 968, 6763, 4399, 1431, 943, 7008, 4104, 1113, 12584, 1247, 12895, 5603, 4282, 13664, 7639, 7199, 18961, 18959, 4280, 4276, 18958, 18957, 22819, 22829, </team_members_id><team_members_names><![CDATA[Ana Perinić Lewis, Natalija Novokmet, Dubravka Havaš Auguštin, Jelena Šarac, Tena Šarić, Noël Cameron, Schell Lawrence, Ellen Demerath, Miran Čoklo, Alen Šelović, Sanja Musić Milanović, Tamara Poljičanin, Vesna Pavlov, Martina Šunj, Ljiljana Muslić, ŽELJKO Romić, Biserka  orehovec, Veselin Škrabić, Olgica Martinis, Deni Karelović, Matea Zajc Petranović, Mirjana Turkalj, Ivana Banić, Denis Polančec, Marcel Lipej, Adrijana Miletić Gospić, Deana Švaljug, Ivana Unić Šabašov, Jelena Živković, Sandra Bulat Lokas, Lucija Zenić, Ana Žižić, Emily Petherick, IRENA BRALIĆ, ]]></team_members_names><keywords_hr><![CDATA[metabolički sindrom, kohortna studija rođenih, rani razvoj, prevencija, čimbenici rizika]]></keywords_hr><keywords_en><![CDATA[metabolic syndrome, birth cohort, early development, prevention, risk factors]]></keywords_en><summary_hr><![CDATA[Metabolički sindrom (MetS) je vodeći uzrok obolijevanja i smrtnosti, s velikim utjecajem na zdravlje stanovništva i visokim troškovima liječenja. Njegova prevalencija je više od 30 % u općoj populaciji Hrvatske, uz posebno visoku stopu na hrvatskim otocima, do 58 %. Specifična obilježja istočnojadranskih otoka (genetički izolati s visokom razinom srođivanja, s miješanjem tradicionalnog i tranzicijskog životnog stila te stalnim depopulacijskim procesima) predstavljaju temelj za razvoj obrazaca čimbenika rizika koji utječu na pojavu MetS-a. Ovaj projekt je pilot-studija čiji su ciljevi: procijeniti prevalenciju poznatih čimbenika rizika (bioloških, ekoloških i ponašajnih) za razvoj MetS-a u ciljnim hrvatskim populacijama istočnojadranskih otoka i susjednog kopnenog područja te koristiti dobivene rezultate kao temelj za razvoj strategije intervencije. Populacijske kohortne studije trudnica i rođene djece su posebno pogodne za proučavanje ranih odrednica zdravlja i bolesti, koje se javljaju još u fetalnom razdoblju i djetinjstvu. Longitudinalni istraživački pristup će se primijeniti na reprezentativnom uzorku od 713 ispitanika u svakoj od dviju skupina: trudnica i njihove djeca u ciljnim populacijama otoka (Hvar, Brač i Vis) i susjednog kopnenog područja Splitsko-dalmatinske županije. Ishod projekta bit će otkrivanje skupova bitnih čimbenika rizika razvoja MetS-a u ciljnim populacijama. Dugoročni ishod je postupno razvijanje osnove djelotvorne strategije intervencije usmjerene na bitne čimbenike rizika nastanka MetS-a. Važnost nalaza ove pilot-studije je stvaranje temelja budućeg usmjerenijeg, populacijski prilagođenog modela rane intervencije, uključivanjem velikog broja bitnih čimbenika rizika za razvoj MetS-a, što će predstavljati značajan doprinos javnom zdravlju. Saznanja i iskustva stečena na temelju provedenih istraživanja doprinijet će stvaranju učinkovitijih programa promocije zdravlja, uzimajući u obzir utvrđene lokalne sociokulturne i okolišne specifičnosti.]]></summary_hr><summary_en><![CDATA[Metabolic syndrome (MetS) is the leading cause of high morbidity and mortality, with enormous impact on population health and medical costs. Its prevalence is more than 30% in the general Croatian population, with especially high rate on Croatian islands, up to 58%. Specific features of the Eastern Adriatic Islands (EAI) (genetic isolates with high level of inbreeding, mixing traditional and transitional lifestyle and continuous depopulation processes) represent a basis for development of specific MetS risk factor patterns. This project is a pilot study with the aims to: assess the prevalence of known risk factors (biological, environmental and behavioral) for the MetS in EAI and nearby mainland area of the targeted Croatian populations and to use this information as a base to develop an intervention strategy. Population-based pregnancy and birth cohort studies are particularly salient for studying early origins of health and disease that begin in fetal life and infancy. A longitudinal approach will be used on a representative sample of 713 participants in each group: pregnant women and children in the targeted populations of the islands (Hvar, Brač and Vis) and nearby mainland area of of the Split-Dalmatia County. The outcome of the project is revealing sets of relevant risk factors for the development of MetS in the studied Croatian populations. The long-term outcome is progressive development of a base for an effective intervention strategy, directed at relevant risk factors for MetS. The importance of this pilot study is developing foundations for a better focused population adjusted model of early intervention in the future. It will include a large number of relevant risk factors for MetS, which will contribute to beneficial public health outcomes. Knowledge and experiences, acquired in this research will contribute to the creation of programs for health promotion, taking into account local socio-cultural and environmental characteristics.]]></summary_en></project><project>
<id>3531</id><title_hr><![CDATA[Utjecaj promjena termohaline cirkulacije u istočnom Mediteranu na planktonske zajednice u južnom Jadranu:ekološki i genetički pristup]]></title_hr><title_en><![CDATA[Influence of thermohaline circulation variations in the Eastern Mediterranean on the plankton community of the South Adriatic: ecological and genetical approach]]></title_en><user_id>1051</user_id><user_firstLast_name>Mirna Batistić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2014-09</proposal_call><code>IP-2014-09-2945</code><acronim><![CDATA[AdMedPlan]]></acronim><duration>01.09.2015 - 31.08.2019</duration><status>Završio</status><financ_value>95.162,25 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Biologija, Kemija, Geofizika, </scie_field_hr><scie_field_en>Biology, Chemistry, Geophysics, </scie_field_en><institution_hr><![CDATA[Sveučilište u Dubrovniku]]></institution_hr><institution_en><![CDATA[University of Dubrovnik]]></institution_en><team_members_id>2889, 3277, 3992, 7600, 13469, 3160, 2977, 2987, 2911, 1519, 2979, </team_members_id><team_members_names><![CDATA[Nenad Jasprica, Davor Lučić, Jakica Njire, Miroslav Gacic, Giuseppe CIVITARESE, Rade Garić, Iris Dupčić Radić, Marijeta  Čalić, Enis Hrustić, Marijana Miloslavić, Ana Car, ]]></team_members_names><keywords_hr><![CDATA[Plankton, alohtone vrste, termohaline cirkulacije, BIOS mehanizam,  dugoročne promjene, južni Jadran, istočni Mediteranean]]></keywords_hr><keywords_en><![CDATA[Plankton, alien species, thermohaline circulations, BIOS mechanism, long-term changes, South Adriatic, East Mediteranean]]></keywords_en><summary_hr><![CDATA[Projekt se temelji na postojanju Bimodalnog oscilirajućeg sustava (BiOS – “Bimodal Oscillating System”), koji djeluje kao povratni mehanizam između Jadranskog i Jonskog mora i rezultira dekadnim promjena u cirkulaciji Sjevernojonskog vrtloga, čime utječe na advekciju ili Modificirane atlantske vode ili Levantinske / Istočnomediteranske vode u Jadran. Advekcija različitih vodenih masa u Jadran je potencijalno jedan od glavnih čimbenika koji utječe na jadranski ekosustav. Glavni mogući utjecaji BiOS-a na jadranski ekosustav su kroz: i) promjenu termohalinih svojstava i razliku gustoće između površinskih i dubokih slojeva južnog Jadrana, koji utječu na zimska konvektivna miješanja; ii) utjecaj na autotrofnu biomasu zbog promjena u koncentraciji nutrijenata; iii) donos različitih vrsta alohtonih organizama u Jadransko i Jonsko more. Cilj ovog projekta je utvrditi stupanj utjecaja advekcije različitih vodenih masa na ekosustav otvorenog južnog Jadrana, prvenstveno kroz praćenje promjena u planktonskim zajednicama, koje prve reagiraju na promjene u ekosustavu zbog kratkog životnog ciklusa i položaja u hranidbenom lancu. Također, primijenit ćemo filogeografske metode, koje podrazumijevaju uporabu jezgrinih i mitohondrijskih genetičkih markera, s ciljem utvrđivanja podrijetla stranih vrsta koje ulaze u Jadran te procjene utjecaja BIOS-a na genetički sastav jadranskih planktonskih populacija, donosom genetički različitih jedinki iz različitih dijelova Mediterana. Točni mehanizmi utjecaja ulaska vodenih masa na produkciju u Jadranu slabo su poznati. Njihovo razumijevanje omogućit će nam predviđanje ulova sitne plave ribe, što bi nam moglo poslužiti kao temelj za jedinstveno upravljanje i održivo ribarstvo kao važne grane hrvatskog gospodarstva.]]></summary_hr><summary_en><![CDATA[This project is based on the existence of the Bimodal Oscillating System (BIOS), a feedback mechanism between the Adriatic and Ionian Sea which results in decadal changes of the Northern Ionian Gyre circulation and consequently on the prevalent advection of either Modified Atlantic Water (MAW) or Levantine/Eastern Mediterranean waters into the Adriatic. The advection of different water masses into the Adriatic is potentially one of the main factors affecting the Adriatic ecosystem. The major potential modes of influence of BiOs on the Adriatic ecosystem are: i) by changing buoyancy content in the South Adriatic which drives the winter convective mixing processes; ii) through impact on the autotrophic biomass due to the change in nutrient availability; iii) by bringing different types of allochthonous organisms into the Adriatic and Ionian Sea. The goal of this project is to determine the magnitude of the impact of alternate advection of water masses on the pelagic ecosystem of the South Adriatic, primarily through tracking the changes in plankton communities, which are the first to react in the ecosystem because of their short life cycle and position in the food chain. We will apply phylogeographic methods, which include the usage of nuclear and mitochondrial genetic markers, in order to determine the origin of alien species entering the Adriatic and to assess the influence of BiOS on genetic composition of Adriatic zooplankton communities through the advection of individuals from different parts of Mediterranean basin. The exact mechanisms of influence of the entering water masses on production of the Adriatic are poorly known. Its comprehension could allow forecasting of small  pelagic fish catches which could serve as a basis for sustainable management of the fisheries, an important part of Croatian economy.]]></summary_en></project><project>
<id>3537</id><title_hr><![CDATA[Napredna metodologija projektiranja prekidačkih istosmjernih pretvornika]]></title_hr><title_en><![CDATA[Advanced design methodology for switching DC-DC converters]]></title_en><user_id>7714</user_id><user_firstLast_name>Adrijan Barić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2014-09</proposal_call><code>IP-2014-09-6405</code><acronim><![CDATA[AdvaDCDC]]></acronim><duration>01.06.2015 - 30.06.2019</duration><status>Završio</status><financ_value>129.802,91 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Elektrotehnika, Temeljne tehničke znanosti, </scie_field_hr><scie_field_en>Electrical engineering, Basic engineering sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id>13699, 13703, 13704, 7123, 13705, </team_members_id><team_members_names><![CDATA[Vladimir Čeperić, Raul Blečić, Tvrtko  Mandić, Igor Krois, Josip Bačmaga, ]]></team_members_names><keywords_hr><![CDATA[projektiranje integriranih sklopova, istosmjerni pretvornici, elektronički  sklopovi snage, galij-nitrid tranzistori, electromag. kompatibilnost]]></keywords_hr><keywords_en><![CDATA[integrated circuit design, DC-DC converters, power electronics, GaN transistors, electromagnetic compatibility]]></keywords_en><summary_hr><![CDATA[Napredna metodologija projektiranja prekidačkih istosmjernih pretvornika razvijena je u ovom projektu. Gornja sklopka, donja sklopa, pobudni i upravljački sklopovi integrirani su u jednom pakiranju, što minimizira utjecaj parazitnih elemenata i omogućava prekapčanja do 10 MHz. Razvit će se pobudni sklop s visokopreciznom kontrolom signala gornje i donje sklopke, što će omogućiti optimiranje mrtvog vremena s obzirom na efikasnost pretvaranja i smanjenje gubitaka za bilo koju kombinaciju parametara pakiranja integriranog sklopa, vanjskih komponenata i tiskane pločice. Posebna je pažnja posvećena projektiranju sklopa za pomak istosmjernog nivoa gornje sklopke. Osim što služi kao pobudni sklop za sklopke velike struje koje se nalaze na čipu, razvijeni pobudni sklop pobuđuje i vanjske pinove integriranog sklopa kako bi omogućio korištenje vanjskih sklopki. Galij-nitrid (GaN) i silicij-karbid (SiC) poluvodički elementi predstavljaju obećavajuće rješenje za visokonaponske i visokoefikasne pretvornike. Istosmjerni pretvornici koji koriste GaN/SiC tranzistore mogu se optimirati korištenjem prethodno razvijenog pobudnog sklopa. Razvijena metodologija omogućit će evaluaciju efikasnosti GaN i SiC elemenata u visokonaponskim prekidačkim primjenama kao i projektiranje kvalitetno optimiranih pretvornika. Tiskana pločica na koju je zalemljen čip pretvornika predstavlja sljedeći ključni dio dizajna pretvornika i ima dominantni utjecaj na određivanje elektromagnetske kompatibilnosti i termičkih svojstava pretvornika. Razvit će se simulacijsko okruženje koje omogućava elektromagnetsko-termičku kosimulaciju istosmjernih pretvornika. Provest će se statistička analiza parametara tiskane pločice i pakiranja integriranog sklopa kako bi se osiguralo da varijacije u proizvodnji ne narušavaju pouzdanost i efikasnost projektiranih pretvornika. ]]></summary_hr><summary_en><![CDATA[Advanced design methodology for switching DC-DC converters is developed. The low-side and high-side switch, their drivers and the control circuitry are integrated into one package which minimizes the parasitic elements and allows switching frequencies up to 10 MHz. A driving-signal circuitry with high-precision adjustable timings is developed. This will allow the optimisation of dead-times with respect to the power conversion efficiency of a converter for any given set of the parameters of the integrated circuit (IC) package, external components and a printed circuit board (PCB). A special attention is given to the design of a level-shifter for a high-side switch. Besides driving the on-chip power switches, the developed driving signal circuitry is routed to external pins of the IC package to enable driving of the externally connected switches. Gallium-nitride (GaN) and silicon-carbide (SiC) semiconductor devices present a promising solution for a high-voltage and high-efficiency power conversion. In order to design a highly efficient converter for high-voltage switching applications by using GaN and SiC power transistors, the GaN/SiC DC-DC converter will be optimised by using adjustable driving-signal circuitry, which is designed at the beginning of the project. The developed methodology will allow the evaluation of the efficiency of the GaN and SiC devices in high-voltage switching applications as well as highly optimised design of the converters. The PCB makes a large part of the design and it has a dominant effect in determination of the electromagnetic compatibility and thermal properties of the converter. A simulation environment which will allow the electromagnetic-thermal co-optimisation of DC-DC converters will be developed. A statistical analysis of the parameters of a PCB and an IC package will be performed to ensure that the variations in the manufacturing process do not compromise the reliability and the efficiency of the designed converters.]]></summary_en></project><project>
<id>3538</id><title_hr><![CDATA[Gradovi hrvatskog srednjovjekovlja: urbane elite i urbani prostor ]]></title_hr><title_en><![CDATA[Cities of the Croatian Middle Ages: Urban Elites and Urban Space]]></title_en><user_id>421</user_id><user_firstLast_name>Irena  Benyovsky Latin</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2014-09</proposal_call><code>IP-2014-09-7235</code><acronim><![CDATA[URBES]]></acronim><duration>15.09.2015 - 14.09.2019</duration><status>Završio</status><financ_value>60.684,85 eur</financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Povijest, </scie_field_hr><scie_field_en>History, </scie_field_en><institution_hr><![CDATA[Hrvatski institut za povijest]]></institution_hr><institution_en><![CDATA[Croatian Institute of History]]></institution_en><team_members_id>633, 330, 383, 436, 534, 1036, 3987, 466, 384, 535, 6365, 509, 476, 11259, 460, </team_members_id><team_members_names><![CDATA[Marija Karbić, Zrinka Pešorda Vardić, Gordan Ravančić, Ante Birin, Dušan  Mlacović, Danijela Doblanović, Ratko Vučetić, Marija Mogorović Crljenko, Ivana Lazarević, Tonija Andrić, Ivana Haničar Buljan, Zrinka Nikolić Jakus, Bruno Škreblin, Anton Ravnikar, Sandra Begonja, ]]></team_members_names><keywords_hr><![CDATA[urbane elite, urbani prostor, hrvatsko srednjovjekovlje, gradovi, prozopografija, socijalna topografija]]></keywords_hr><keywords_en><![CDATA[urban elites, urban space, Croatian Middle Ages, cities, prosopography, social topography]]></keywords_en><summary_hr><![CDATA[U središtu ovog projekta je odnos između prostora i društva u gradovima hrvatskog srednjovjekovlja, odnos koji je u recentnoj međunarodnoj historiografiji naglašen kao ključan za razumijevanje urbane povijesti srednjega vijeka. Fokus projekta URBES su odabrani gradovi srednjovjekovne Slavonije (Gradec i Varaždin) i odabrani istočnojadranski gradovi, od istarskih komuna na sjeveru do Dubrovnika na jugu. Ovaj projekt istražuje razvijeni i kasni srednji vijek (trinaesto do šesnaesto stoljeće). Glavna hipoteza URBES-a je da su elite središnja društvena grupa odgovorna za urbane razvoje. Cilj projekta URBES je pružiti odgovore na pitanja kao: koja je bila uloga urbanih posjeda (s obzirom na njihovu veličinu, poziciju i kontinuitet) u oblikovanju srednjovjekovnih elita? Kako su se elite u odabranim gradovima hrvatskog srednjovjekovlja transformirale s obzirom na gradski prostor? Koji je bio njihov utjecaj na urbani prostor, i kakva je bila njihova prisutnost u urbanom prostoru? Na temelju bogatih postojećih baza podataka, projekt će rekonstruirati i analizirati gustu mrežu obitelji, kućanstava, nekretnina i kuća u odabranim gradovima i pratiti njihov razvoj tijekom vremena da bi se dobio novi uvid u društvene strukture i urbani prostor. Iako su gradovi hrvatskog srednjovjekovlja u središtu projekta URBES, projekt se namjerava fokusirati na pitanja koja nadilaze problem pojedinih gradova kako bi se uspoređivali slični fenomeni u širem geografskom i političkom kontekstu, te kako bi pratili rezidencijalnu mobilnost urbanih elita. Također, projekt predlaže interdisciplinarni pristup i korištenje relevantnih informatičkih mogućnosti.]]></summary_hr><summary_en><![CDATA[At the centre of this project is the relationship between the space and the society in  cities of Croatian Middle Ages, a relationship that in recent international historiography has been stressed as key to understanding of the urban history of the Middle Ages. The foci of URBES project are selected medieval Slavonian towns (Gradec and Varaždin) and selected Eastern Adriatic towns, from Istrian communes in the north to Dubrovnik in the south. This project examines High and Late Middle Ages (thirteenth to mid-sixteenth centuries). The main hypothesis of the URBES project is that the elites were central to urban developments. The goal of the URBES project is to provide answers to questions such as: What was the role of the urban estates (with regard to its size, location and continuity) in the formation of medieval elites? How did urban elites in chosen towns of Croatian Middle Ages transform in relation to urban space? What was their influence upon the urban space, and their presence in the urban space? On the basis of the rich extant databases, the project will reconstruct and analyse dense matrix of families, households, properties and buildings in chosen towns, and trace their evolution over time, gaining new insights into social structures and urban space. Although the cities of the Croatian Middle Ages are in the centre of URBES, the project will focus on the issues that go beyond the scale of individual towns in order to make comparisons of similar phenomena between cities and towns in a broader geographical and political context, and to trace residential mobility of the urban elites. Also, the project proposes the interdisciplinary approach, with the use of relevant IT  possibilities.]]></summary_en></project><project>
<id>3540</id><title_hr><![CDATA[Uloga strukturnih reformi u poticanju vanjske konkurentnosti zemalja Europske unije]]></title_hr><title_en><![CDATA[The role of structural reforms in boosting external competitiveness in European Union countries]]></title_en><user_id>5806</user_id><user_firstLast_name>Boris Cota</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2014-09</proposal_call><code>IP-2014-09-5476</code><acronim><![CDATA[ROSPEC]]></acronim><duration>01.05.2015 - 30.04.2019</duration><status>Završio</status><financ_value>34.352,33 eur</financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Ekonomija, </scie_field_hr><scie_field_en>Economy, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Ekonomski fakultet u Zagrebu]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Economics and Business]]></institution_en><team_members_id>5144, 6292, 4716, 13295, 4460, </team_members_id><team_members_names><![CDATA[Nataša Erjavec, Zrinka Lukač, Željko  Bogdan, Velibor Mačkić, Lucija Rogić, ]]></team_members_names><keywords_hr><![CDATA[Ekonomska politika, strukturne reforme, vanjska konkurentnost, tekući račun, izvoz, cjenovna konkurentnost, necjenovna konkurentnost, tržište proi]]></keywords_hr><keywords_en><![CDATA[economic policy, structural reforms, external competitiveness, current account, export, price competiveness, non-price competiveness, product market, ]]></keywords_en><summary_hr><![CDATA[Cilj projekta je analizirati učinke strukturnih reformi na vanjsku konkurentnost u zemljama EU. Ovaj je problem postao aktualan nakon desetljeća ekonomskog rasta koji je bio vođen domaćom potražnjom uslijed velikih priljeva kapitala u mnoga periferna gospodarstva Europe. Priljev kapitala vodio je stvaranju velikih balona na tržištu stanova i doveo je do ekspanzije u tim zemljama. Ekspanzija je dovela do porasta troškova i cijena, koje su rasle znatno više u periferiji nego u središtu. Periferne ekonomije su postajale sve manje konkurentne što je postalo problem kad je došlo do prekida dotoka kapitala. Posljedica je bio snažan pad ekonomske aktivnosti što je dovelo do gubitka domaće potražnje, ali je zbog gubitka konkurentnosti inozemna pozicija ostala i dalje slaba. Problem je postao veći kada su smanjeni prihodi i očekivanja o dugotrajnoj gospodarskoj slabosti dovela do snažnih proračunskih deficita. Zbog panike na tržištu obveznica, središte Eurozone je tražilo snažne programe štednje. Štednja je dovela do još dubljeg pada gospodarstava periferije što je, bez ekspanzije u jezgri, rezultiralo snažnim padom u ukupnom europskom gospodarstvu. Rigidnosti na tržištu rada, loše poslovno okruženje i struktura domaće proizvodnje usporavaju oporavak konkurentnosti (Felipe, Kumar, 2011). Reforme na tržištima rada i proizvoda povećavaju mobilnost proizvodnih faktora poboljšavajući njihovu alokaciju. Reforme na financijskom tržištu poboljšavaju vanjsku konkurentnosti zbog veće konkurencije i daljnje integracije u EU. Glavni cilj projekta je pokazati da su strukturne reforme nužne kako bi se olakšala prilagodba plaća i poboljšalo poslovno okruženje (Orszaghova et. al, 2013). Projekt će uzeti u obzir i da se vanjska konkurentnost može objasniti kao dokaz visoke produktivnosti poduzeća. Ciljevi projekta će biti postignuti kroz implementaciju odgovarajućih ekonometrijskih tehnika. Projekt može pomoći poboljšanju vanjske konkurentnost i ukupne ekonomske aktivnosti u zemljama EU.]]></summary_hr><summary_en><![CDATA[The aim of project is to analyse the effects of structural reforms on external competitiveness in EU countries. This issue became important after a decade of economic growth driven through domestic demand fuelled by huge flows of capital to many european pheriphery. These capital flows fed huge housing bubbles and created booms in the countries receiving the inflows. The booms caused the rise of costs and prices much more in the periphery than in the core. Peripheral economies became increasingly uncompetitive, which was a problem once the capital inflows stopped. The result was slumps in the periphery, which lost a lot of internal demand but remained weak on the external side thanks to the loss of competitiveness. The problem was greatly exacerbated when the combination of slumping revenues and the prospect of protracted economic weakness led to large budget deficits. There was panic in the bond market and the EU core demanded harsh austerity programs. Austerity led to much deeper slumps in the periphery and without expansion in the core, the result was in fact a slump for the EU economy as a whole. Labor market rigidities, weak business environment and structure of domestic production make competition recovery sluggish (Felipe, Kumar, 2011). Labor and product market reforms increase the mobility of production factors improving their allocation in the economy. Financial market reforms boost competiveness as a consequence of higher competition and further integration in EU. The main goal of the project is to show that reforms in these areas are needed to facilitate wage adjustment and improve the business environment (Orszaghova et. al, 2013). The project takes into account that external competitiveness can be explained as an expression of high ?rm-level productivity. Projects goals will be achieved through implementation of appropriate econometrics techniques. This project can help to improve external competitiveness and overall economic activity in EU countries.]]></summary_en></project><project>
<id>3544</id><title_hr><![CDATA[Štetni učinci pojedinačnih i kombiniranih mikotoksina Aspergillus vrsta]]></title_hr><title_en><![CDATA[Adverse effects of single and combined mycotoxins produced by Aspergilli]]></title_en><user_id>12487</user_id><user_firstLast_name>Maja Šegvic Klarić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2014-09</proposal_call><code>IP-2014-09-5982</code><acronim><![CDATA[MycotoxA]]></acronim><duration>08.02.2016 - 07.12.2020</duration><status>Završio</status><financ_value>132.693,87 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Javno zdravstvo i zdravstvena zaštita, Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Public health and health services, Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Farmaceutsko-biokemijski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Pharmacy and Biochemistry]]></institution_en><team_members_id>12800, 1301, 13122, 13149, 343, 3520, 13379, 5026, 2516, 201, 179, 12345, </team_members_id><team_members_names><![CDATA[DANIELA JAKŠIĆ DESPOT, Ana Mornar Turk, Biljana Nigović, Dubravko Jelić, Dubravka Rašić, Andrea Hulina, Sándor Kocsubé, Davor Želježić, Nevenka Kopjar, Maja Peraica, Davorka Breljak, Lada Rumora, ]]></team_members_names><keywords_hr><![CDATA[Aspergillus, mikotoksini, interakcije, oksidacijski stres, genotoksičnost, imunotoksičnost]]></keywords_hr><keywords_en><![CDATA[Aspergilli, mycotoxins, interactions, oxidative stress, genotoxicity, immunotoxicity]]></keywords_en><summary_hr><![CDATA[Prema EU dokumentu o klimatskim promjenama u južnoj i jugoistočnoj Europi očekuje se povećanje temperature za 4-5° C, te sušna razdoblja u kombinaciji s velikom količinom oborina i poplave. Takve klimatske promjene  mogu se  odraziti na obrazac pojavnosti plijesni-producenata mikotoksina. Aspergillus vrste i njihovi mikotoksini mogli bi postati češći kontaminanti hrane u našem podneblju nego li je to bilo do sada, što može značajno povećati rizik za zdravlje bilo da se radi o unosu toksina ingestijom ili inhalacijom. S mikotoksikološkog stajališta, Aspergillus vrste iz sekcija Flavi, Circumdati, Nigri, Versicolores i Terrei zaslužuju  posebnu pozornost zbog proizvodnje aflatoksina B1, okratoksina A, fumonizina, sterigmatocistina i citrinina. Mehanizam toksičnosti tih mikotoksina još uvijek nije razjašnjen. Jedan od mogućih mehanizama koji igra značajnu ulogu u imunotoksičnosti, genotoksičnosti i kancerogenosti mikotoksina je oksidacijski stres. To bi se moglo spriječiti korištenjem nekih prirodnih antioksidanata kao što je resveratrol. Stoga su ciljevi ovog projekta: 1) istražiti pojavnost genotipova Aspergillus vrsta u hrani i zraku zatvorenih plijesnima opterećenih prostora, primjenom sekvenciranja ITS /CaM regije DNA; 2) ispitati toksinogenosti Aspergillus vrsta  in vitro i ex vivo pomoću tekućinske kromatografije visoke učinkovitosti u kombinaciji s masenom spektrometrijom; 3) razjasniti ulogu oksidacijskog stresa u mehanizmu toksičnosti mikotoksina in vitro / in vivo određivanjem lipidne peroksidacije, staničnih antioksidanta i ekspresije proteina toplinskog šoka; 4) ispitati toksične interakcije mikotoksina (aditivnost, sinergizam, antagonizam) u dvojnim i trojnim kombinacijama koncentracija koje odgovaraju EU limitu koristeći stanične linije i statističke modele,  te 5) ispitati antioksidativni potencijal resveratrola. Rezultati će pružiti temelj za preporuke i / ili reviziju postojećih regulatornih smjernica kako bi se smanjio rizik za ljudsko zdravlje.]]></summary_hr><summary_en><![CDATA[The EU green paper on climate change in Europe foresees an increase of 4-5°C in temperature and a water availability reduction in combination with higher rainfall and floods in southern and south-eastern Europe. Such changes in climatic conditions may reflect on the food contamination pattern through mycotoxin-producing moulds. Thus, mycotoxin-producing Aspergilli may become more frequent in our region, increasing the risk of exposure to their mycotoxin mixtures in food and the air of damp dwellings. From the mycotoxicological point of view, species from sections Flavi, Circumdati, Nigri, Versicolores and Terrei require particular attention due to the production of aflatoxin B1, ochratoxin A, fumonisins, sterigmatocystin and citrinin. The mechanism of toxicity of these mycotoxins has still not been elucidated. One of the possible mechanisms that plays a significant role in the immunotoxicity, genotoxicity and carcinogenicity of mycotoxins is oxidative stress. This mechanism could be contravened by antioxidants such as resveratrol. Therefore, the objectives of this project include: 1) research on occurrence and genotyping of airborne and foodborne Aspergilli using the ITS/CaM region of DNA sequence-based analysis; 2) checking the ability of Aspergilli to produce mycotoxins in vitro and ex vivo using high performance liquid chromatography coupled with mass spectrometry; 3) clarifying the involvement of oxidative stress in the toxicity of mycotoxins in cell lines and animal model by measuring lipid peroxidation, cell antioxidants and expression of heat shock proteins; 4) estimation of mycotoxin toxic interactions (additivity, synergism, antagonism) in binary and tertiary combinations at their EU regulatory limits using cell lines and statistical models, and 5) evaluation of resveratrol protection from oxidative stress. Our results will provide the base for recommendations and/or revision of current regulatory guidelines in order to minimize risks for human health.]]></summary_en></project><project>
<id>3550</id><title_hr><![CDATA[Od prašuma do oranica: povijest antropizacije šuma u Slavoniji od srednjeg vijeka do početka 20. stoljeća]]></title_hr><title_en><![CDATA[From Virgin Forests to Ploughlands: History of Anthropisation of Forests in Slavonia from the Middle Ages to the Beginning of the 20th Century]]></title_en><user_id>1311</user_id><user_firstLast_name>Robert Skenderović</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2014-09</proposal_call><code>IP-2014-09-6719</code><acronim><![CDATA[FVTPHOAFS]]></acronim><duration>01.06.2015 - 31.05.2019</duration><status>Završio</status><financ_value>59.645,63 eur</financ_value><scie_area_hr>Humanističke znanosti, Biotehničke znanosti, </scie_area_hr><scie_area_en>Humanities, Biotechnical sciences, </scie_area_en><scie_field_hr>Povijest, Šumarstvo, Drvna tehnologija, </scie_field_hr><scie_field_en>History, Forestry, Wood technology, </scie_field_en><institution_hr><![CDATA[Hrvatski institut za povijest]]></institution_hr><institution_en><![CDATA[Croatian Institute of History]]></institution_en><team_members_id>783, 5743, 13381, 7174, 1164, 4458, 23208, </team_members_id><team_members_names><![CDATA[Stanko Andrić, Karlo Beljan, Krunoslav Teslak, Anđelko Vlašić, Milan Vrbanus, Dinko Župan, Josip  Parat, ]]></team_members_names><keywords_hr><![CDATA[povijest šuma, Slavonija, antropizacija, modernizacija, održiv razvoj]]></keywords_hr><keywords_en><![CDATA[history of forests, Slavonia, anthropisation, modernisation, sustainable development]]></keywords_en><summary_hr><![CDATA[Šume predstavljaju jedno od najvažnijih prirodnih bogatstava Slavonije. Zadatak je predloženog projekta utvrditi razmjere čovjekova utjecaja na slavonske šume u razdoblju od srednjeg vijeka do početka 20. stoljeća, te utvrditi važnost i nužnost toga procesa za opću modernizaciju Slavonije, pogotovo u vrijeme izrazite industrijalizacije i urbanizacije u 19. stoljeću. Središnji cilj projekta je odgovoriti na pitanje koliki su šume stvarno bile kapital u gospodarskom smislu, tko je tim kapitalom raspolagao i kako je taj kapital ulagan u javno dobro, odnosno kako je pretvaran u društveni i kulturni kapital. Projekt će rezultirati s  web stranicom s interaktivnom kartom šumskih prostora, radionicom o povijesnim izvorima, knjigom izabranih povijesnih izvora, znanstvenim skupom, zbornikom radova znanstvenog skupa, knjigom grupe autora o antropizaciji šuma u Slavoniji te nizom znanstvenih radova u domaćim i svjetskim publikacijama. ]]></summary_hr><summary_en><![CDATA[The forests are among the greatest natural riches of Slavonia. This project aims to determine the extent of human influence on the Slavonian forests from the Middle Ages to the beginning of the 20th century, and to determine the importance and essentiality of this process for the modernisation of Slavonian region, especially during the period of increasing industrialisation and urbanisation in the 19th century. The main objective of the project is to answer questions how important an economic asset they were, who owned and exploited this asset and how it was invested in the public good, that is, how it was transformed into the social and cultural capital.The results will be achieved through the following activities: creating the website with an interactive map of forest complexes, organising the workshop on the historical sources, publishing the book with a selection of sources relevant to the history of forests, organising the conference, publishing the book of conference proceedings, and, finally, publishing the collaborative monograph on the anthropisation of the forests in Slavonia, as well as a series works in domestic and foreign journals.]]></summary_en></project><project>
<id>3553</id><title_hr><![CDATA[Dijalektološka i jezičnopovijesna istraživanja hrvatskoga jezika]]></title_hr><title_en><![CDATA[Researches in dialectlology and history of the Croatian language]]></title_en><user_id>13675</user_id><user_firstLast_name>Josip Lisac</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2014-09</proposal_call><code>IP-2014-09-1946</code><acronim><![CDATA[DJIH]]></acronim><duration>01.05.2015 - 30.04.2019</duration><status>Završio</status><financ_value>29.796,27 eur</financ_value><scie_area_hr>Humanističke znanosti, Društvene znanosti, </scie_area_hr><scie_area_en>Humanities, Social sciences, </scie_area_en><scie_field_hr>Filologija, Sociologija, Psihologija, Povijest, Etnologija i antropologija, Kroatologija, </scie_field_hr><scie_field_en>Philology, Sociology, Psychology, History, Ethnology and anthropology, Croatology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zadru]]></institution_hr><institution_en><![CDATA[University of Zadar]]></institution_en><team_members_id>13304, 12688, 13434, 13146, </team_members_id><team_members_names><![CDATA[Lina Pliško, Marijana Tomelić Ćurlin, Marijana Fabijanić, Josip Galić, ]]></team_members_names><keywords_hr><![CDATA[dijalekt, književnost, kodeks, narječje, romanizam]]></keywords_hr><keywords_en><![CDATA[dialect, literature, codex, group of dialects, romance loanwords]]></keywords_en><summary_hr><![CDATA[Znanstveni projekt „Dijalektološka i jezičnopovijesna istrživanja hrvatskoga jezika“ (DJIH) obrađuje dvije strane medalje hrvatskoga jezika, dijalektološku i jezičnopovijesnu.  To znači da obrađuje suvremeno hrvatsko dijalekatno stanje organskih idioma i genezu hrvatskih narječja, s jedne strane, i hrvatsku jezičnu baštinu kako je ona zapisana u književnim djelima i u drugim jezičnim spomenicima, s druge strane. Očekuje se da će projekt rezultirati znanstvenim rezulatima velike važnosti. Riječ je prvenstveno o sedam monografija iz pera petero istraživača, a zatim i o  drugim prinosima. Svi ti prinosi obogaćivat će poznavanje hrvatskoga jezika od Istre do Dubrovnika i od Gorskoga kotara do zapadnoga Srijema, kao i svagdje drugdje gdje ima hrvatskih govornika ili ih je bilo u prošlosti. Može se očekivati da će projekt u znatnoj mjeri unaprijediti hrvatsku genetsku lingvistiku, prije svega proučavanje kajkavskoga i čakavskoga narječja, a zatim i hrvatske dijalektologije u cjelini. To znači da će u punoj mjeri biti obuhvaćeni i govori štokavskoga narječja, kao i idiomi torlačkoga narječja kojima govore Hrvati. Posebno je važno da će rad na projektu bitno unaprijediti kvalitetu istraživanja svih angažiranih znanstvenika, naročito onih najmlađih. Donijet će ne samo činjenične novosti u hrvatsku genetsku lingvistiku, on će biti i zametak planiranoga Centra za hrvatsku dijalektologiju pri Sveučilištu u Zadru.]]></summary_hr><summary_en><![CDATA[Scientific project „Researches on dialectology and history of the Croatian language“ (DJIH) deals with two sides of the medal of the Croatian language, its dialectological side and the side of its linguistic history. It means that the project discusses contemporary Croatian dialectal situation of organic idioms  and the genesis of Croatian dialects, on one side, and the Croatian linguistic heritage as written (recorded) in literary works and other linguistic monuments, on the other side. It is expected that the project will offer scientific results of great importance. They mainly refer to seven monographs written by five authors, and to other contributions, too. All those contributions will enrich the (present) knowledge about the Croatian language from Istria to Dubrovnik and from Gorski kotar to the western part of Srijem, as well as elsewhere, i. e. in the areas where the Croatian speaking population is present or was present in the past. It could be expected that the project would improve the Croatian genetic linguistics, first of all the study of the Kajkavian and Čakavian dialect, and then the Croatian dialectology as a whole. It means that speeches of the Štokavian dialect will also be entirely included in the research, as well as the idioms of the Torlakian dialect spoken by Croats. It is particularly important that the work on this project will considerably improve the quality of scientific activity of each scientist engaged in this project (member of this project team), particularly of junior researchers.  Thanks to this project not only new facts will be available, but it will also serve as a basis for a future Centre for Croatian dialectology, (planned to be founded) at the University of Zadar. ]]></summary_en></project><project>
<id>3556</id><title_hr><![CDATA[Zelena  otapala  za  zelene  tehnologije]]></title_hr><title_en><![CDATA[Green Solvents for Green Technologies]]></title_en><user_id>3228</user_id><user_firstLast_name>Ivana Radojčić Redovniković</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2014-09</proposal_call><code>IP-2014-09-9550</code><acronim><![CDATA[GREEN]]></acronim><duration>01.09.2015 - 31.08.2018</duration><status>Završio</status><financ_value>78.412,24 eur</financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Biotehnologija, Prehrambena tehnologija, </scie_field_hr><scie_field_en>Biotechnology, Food technology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prehrambeno-biotehnološki fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Food Technology and Biotechnology]]></institution_en><team_members_id>5279, 6224, 13472, 6458, 6482, 5443, 6126, 13471, 3968, 13470, 18925, 18926, 21346, </team_members_id><team_members_names><![CDATA[Višnja Gaurina Srček, Karin Kovačević Ganić, Dubravka Škevin, Aleksandra Sander, Jasna Prlić Kardum, Kristina  Radošević, Marina Cvjetko Bubalo, Klara Kraljic, Jasna Halambek, Marko Obranović, Anamarija Mitar, Kristina  Zagajski Kučan, Manuela  Panić, ]]></team_members_names><keywords_hr><![CDATA[biokataliza, biološkiaktivni spojevi, eutektična  otapala, ionske kapljevine, pročišćavanje tekućih goriva]]></keywords_hr><keywords_en><![CDATA[biocatalysis, biologically active compounds, deep euectic solvents, fuel purification, ionic liquids]]></keywords_en><summary_hr><![CDATA[Posljednjih su nekoliko godina globalna ekonomska kriza,rastuće cijene hrane, energije i drugih roba te povećana svijesto utjecaju čovjeka na okoliš potaknuli koncept zelene ekonomijeu središte političkih, gospodarskih i znanstvenih rasprava. Uskladu s time ionske kapljevine i eutektična otapala intenzivnose istražuju s ekološkog, tehnološkog i ekonomskog gledištakao zamjena za tradicionalna organska otapala. Ciljpredloženog Projekta jest stjecanje znanja o prirodnim ionskimkapljevinama i eutektičnim otapalima dizajniranih za specifičneprocese u prehrambenoj tehnologiji, biotehnologiji i kemijskojtehnologiji. U sklopu Projekta pripravit će se ionske kapljevine ieutektična otapala iz prirodnih sirovina poput kolinijevih soli,ugljikohidrata, organskih kiselina i aminokiselina, odreditinjihova fizikalno-kemijska svojstva i toksičnost te primjeniti kaootapala u ekstrakciji biološki aktivnih spojeva iz nusproizvodaprehrambene industrije, biokatalitičkim reakcijama te procesupročišćavanja tekućih goriva. Prema našim saznanjima uRepublici Hrvatskoj jedina smo istraživačka grupa koja sesustavno bavi izučavanjem zelenih otapala, a što je u skladu sključnim ciljevima EU vezanim uz očuvanje okoliša. S tim u svezi,financiranje ovog projekta iznimno je važno za nastavak našegmultidisciplinarnog istraživanja zelenih otapala (priprava,karakterizacija i primjena) što je također od velikog interesa i zahrvatsku akademsku zajednicu. Provedbom predloženogProjekta profilirat ćemo se u vodeću grupu u područjuistraživanja prirodnih ionskih kapljevina i eutektičnih otapala, nesamo u RH već i u inozemstvu. Također, stečeno znanje moćićemo prenijeti zainteresiranim industrijskim parterima kako biimplementirali zelena otapala u postojeće i/ili nove procese.]]></summary_hr><summary_en><![CDATA[Global economic crisis, soaring commodity prices and growingawareness of humanity&#39;s impact on the environment havepushed the “green economy” concept into mainstream policydebate in recent years. Accordingly, as a promising alternativeto traditional organic solvents from both the environmental andtechnological perspectives, neoteric solvents (neoteric = new,recent, modern), ionic liquids (ILs) and deep eutectic solvents(DESs), have been dramatically expanding in popularity as anew generation of designer solvents with possible applicationsin various industrial fields. The aim of proposed Project is to gainan in-depth understanding of the natural ILs and DESs withfine-tuned properties, as well as to implement these solventsinto food technology, biotechnology and chemical technology. Within the Project ILs and DESs, based on renewable sourcessuch as cholinium salts, sugars, organic acids and amino acids,will be prepared and characterized, followed by examination oftheir applicability as solvents for extraction of phenoliccompounds from wine and oil by-product, in biocatalyticreactions and in fuel purification process. To our knowledge, inthe Republic of Croatia we are the only research group involvedin multidisciplinary and systematic approach in the investigationof ILs and DESs. Thus, proposed Project would enable ourfurther research in the field of preparation, characterization andapplication of these new green solvents, which is of greatimportance for Croatian academic community in order tosuccessfully follow the EU directives. Additionally, knowledgegained through proposed Project will profile us as the leadinggroup in the field of natural ILs and DESs research, both in theRepublic of Croatia and EU, for fostering knowledge transfer toacademia and potential industry partners. ]]></summary_en></project><project>
<id>3561</id><title_hr><![CDATA[Utjecaj deformacija od puzanja na nosivost čeličnih i aluminijskih stupova pri djelovanju požara]]></title_hr><title_en><![CDATA[Influence of creep strain on the load capacity of steel and aluminium columns exposed to fire]]></title_en><user_id>11212</user_id><user_firstLast_name>Neno Torić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2014-09</proposal_call><code>UIP-2014-09-5711</code><acronim><![CDATA[Column creep]]></acronim><duration>01.10.2015 - 30.09.2018</duration><status>Završio</status><financ_value>108.368,17 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Građevinarstvo, </scie_field_hr><scie_field_en>Civil engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Splitu Fakultet građevinarstva, arhitekture i geodezije]]></institution_hr><institution_en><![CDATA[University of Split, Faculty of Civil Engineering, Architecture and Geodesy]]></institution_en><team_members_id>13198, 7970, 13185, 13099, 13156, 13226, </team_members_id><team_members_names><![CDATA[Ian Burgess, Bernardin Peroš, Alen Harapin, IVICA BOKO, Ivana Uzelac, Vladimir Divić, ]]></team_members_names><keywords_hr><![CDATA[čelik, aluminij, požar, puzanje, reološki model, analitički model, stupovi, epruvete]]></keywords_hr><keywords_en><![CDATA[steel, aluminium, fire, creep, rheological model, analytical model, column, coupon]]></keywords_en><summary_hr><![CDATA[Deformacija od puzanja pri visokim temperaturama predstavlja jedan od značajnih čimbenika u odgovoru čeličnih i aluminijskih konstrukcija u ekstremnim uvjetima pri djelovanju požara. Svrha ovog projekta jest iznalaženje novih modela puzanja koji su primjenjivi za aktualno korištene slitine čelika i aluminija kao i analiza utjecaja puzanja na čelične i aluminijske stupove koji predstavljaju najosjetljiviji dio nosive konstrukcije s aspekta kolapsa. Projekt u početnom stadiju obuhvaća eksperimentalno određivanje stacionarnih krivulja puzanja čelika i aluminija koje su određene na nizu nivoa temperature i naprezanja u svrhu određivanja adekvatnih analitičkih/reoloških modela puzanja. Potom se planira implementacija dobivenih modela puzanja u istraživačke kodove razvijene na ustanovi voditelja projekta kao i na ustanovi vanjskog suradnika kojim bi se numerički opisalo ponašanje čeličnih i aluminijskih stupova uslijed djelovanja puzanja. Sljedeći stadij projekta odnosi se na provođenje eksperimentalnog istraživanja koje uključuje ispitivanje čeličnih i aluminijskih stupova izloženih različitim nivoima opterećenja kao i specifičnim temperaturnim krivuljama koje bi inducirale razvoj deformacija od puzanja u stupovima. U posljednjem stadiju projekta izvršila bi se verifikacija dobivenih modela puzanja nad dobivenim rezultatima ispitivanja stupova. Ispitivanjem čeličnih i aluminijskih stupova dobio bi se uvid u ponašanje stupova uslijed razvoja deformacija od puzanja kao i uvid koji temperaturni scenario uzrokuje značajan razvoj navedenih deformacija. Zaključci dobiveni na temelju opisanih eksperimenata koristili bi se i za unaprjeđenje pravila projektiranja čeličnih i aluminijskih konstrukcija u požaru.]]></summary_hr><summary_en><![CDATA[High temperature creep represents one of the important factors influencing the response of steel and aluminium structures during fire exposure. The purpose of the project is to develop new types of creep models applicable to new types of steel and aluminium alloys and to conduct the analysis of the influence of creep strain on the behaviour of steel and aluminium columns, which represent the most sensitive parts of the whole structure during collapse stage. The initial stage of the project covers conducting tests for determining stationary creep curves.  The curves would be obtained on different temperature and stress levels with the purpose of creating new types of analytical/rheological creep models.   The developed creep models are intended to be implemented into two research codes developed by the PI&#39;s host institution and by the institution of the external member of the project team. The codes will subsequently be used for numerical modelling of the behaviour of steel and aluminium columns influenced by creep. Following the implementation of the creep models, fire tests which cover testing of steel and aluminium columns exposed to different load and temperature levels are planned, including transient heating curves which would induce significant development of creep strain in the columns. In the final stage of the project verification of the developed creep models is planned using columns’ fire test results. A new insight into the behaviour of steel and aluminium columns under creep influence would be obtained including the insight into types of fire heating scenarios causing a significant increase of creep strain. Conclusions obtained on the basis of the performed tests would be suitable for creating new set of design rules for steel and aluminium structures in fire. ]]></summary_en></project><project>
<id>3567</id><title_hr><![CDATA[Uloga upale u razvoju zloćudnog tumora mokraćnog mjehura]]></title_hr><title_en><![CDATA[Role of inflammation in bladder cancer pathogenesis]]></title_en><user_id>5769</user_id><user_firstLast_name>Janoš  Terzić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2014-09</proposal_call><code>IP-2014-09-1904</code><acronim><![CDATA[iBC]]></acronim><duration>28.10.2015 - 27.10.2019</duration><status>Završio</status><financ_value>124.493,99 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Splitu, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Split School of Medicine]]></institution_en><team_members_id>3080, 5640, 5111, 7062, 4462, 13754, 19132, </team_members_id><team_members_names><![CDATA[Viljemka Bučević Popović, Marina Degoricija, Jelena Korać Prlić, Sergei Grivennikov, Marijan Šitum, Boris Mihaljevic, Maria Bošković, ]]></team_members_names><keywords_hr><![CDATA[mokraćni mjehur, rak, upala, mikrobiom, STAT3, IL-6]]></keywords_hr><keywords_en><![CDATA[bladder, cancer, inflammation, microbiome, STAT3, IL-6]]></keywords_en><summary_hr><![CDATA[Oko 20% smrtnih slučajeva od zloćudnih tumora posljedica je kronične upale. Virusne i bakterijske infekcije, infestacije parazitima, autoimunost i iritirajuće kemikalije uzrokuju upalne promjene koje stimuliraju začetak zloćudnih tumora, njihov ras i metastaziranje. Drugi istraživači i mi smo pokazali da su ključne molekularne poveznice između kronične upale i zloćudnih tumora citokin IL-6 i transkripcijski čimbenik STAT3. Postaje sve očitije da i mikrobni sastav pojedinog tkiva ima važnu ulogu u razvoju kronične upale i zloćudnih tumora. Uloga upale u patogenezi zloćudnih tumora mokraćnog mjehura (TMM) slabo je proučena iako upala izazvana sa Schistosoma haematobium potiče razvoj TMM, dok se upala uzrokovana s BCG uspješno koristi za njegovo liječenje.Za pročavanje upale u razvoju TMM koristiti ćemo najmodernije mišje modele (tzv. knock-out miševe) koijma će tumori biti inicirati s BBN-om. Analizirati ćemo: (1) ulogu IL-6 i (2) ulogu STAT3 u razvoju TMM kao i (3) terapijski potencijal STAT3 inhibitora. Nadalje planiramo (4) proučavati važnosti mikrobioma u nastanku TMM koristeći mišji model te bolesti uz upotrebu antibiotika koji će promijeniti sastav mikrobioma. Proučavajući (5) mikrobiomski sastav urina osoba s TMM i zdravih jedinki pokušati ćemo povezati određene mikrobe s TMM. Projekt proučava temeljne odlike zloćudnih tumora mokraćnog mjehura pa ukoliko se pokaže da smanjivanje aktivnosti STAT3 usporava razvoj TMM naši rezultati mogu potaknuti stvaranje novih lijekova (inhibitora STAT3) za TMM. Rezultati proučavanja mikrobioma mogu dovesti do novih preventivinih mjera (razvoja cjepiva ili upotrebe antibiotika). Kako je TMM sedmi tumor po učestalosti predloženi projekt je od velikog medicinskog, socijalnog i ekonomskog značaja. Članovi projektnog tima su iskusni istraživači su kao ključni znanstvenici objavljivali otkrića u najboljim časopisima poput Cancer Cell i Nature Genetics, što jamči uspješnu realizaciju projekta. ]]></summary_hr><summary_en><![CDATA[Around 20% of cancer deaths are a consequence of chronic inflammation. Viral and bacterial infections, parasitic infestation, autoimmunity or chemical irritants cause inflammatory changes that stimulate cancer initiation, promotion and metastasis. We and others have shown that main molecular links between inflammation and cancer are cytokine IL-6 and its transcription factor STAT3. It is becoming obvious that microbiome composition of particular niche is important element of inflammation and cancer development. The role of inflammation in urinary bladder cancer (BC) pathogenesis is poorly understood although chronic inflammation caused by Schistosoma haematobioum has pro-tumorigenic effect while acute inflammation caused by BCG is successfully used as a therapy for BC. To investigate the role of inflammation in BC development we will use BBN induced BC mice models and will study: (1) the role of IL-6 (by using IL-6 KO mice); (2) the role of STAT3 by assessing its targeted deletion in mice urothelium and (3) therapeutic potential of STAT3 inhibitor. Additionally, we plan to (4) test importance of microbiome in BC development by using mice BC model and antibiotic treatment to manipulate bladder microbiome composition and to (5) analyze human bladder cancer microbiome, in order to associate BC with specific microbiota.This project addresses fundamental questions of bladder cancerogensis. If altering STAT3 activity has inhibitory effect on BC development that finding can lead to new therapies (use of STAT3 inhibitors) for established BC. Findings generated by the microbiome analysis can lead to novel preventive measures (microbiota manipulation by antibiotics or vaccination). Team members are experienced scientist with publications in Cancer Cell and Nature Genetics which is securing successful realization of the project. Because BC is the seventh most common malignancy, proposed project is of great medical, social and economic importance.]]></summary_en></project><project>
<id>3569</id><title_hr><![CDATA[Repeticije višeg reda i globalna repeticijska mapa za genome neandertalca, čovjeka i čimpanze]]></title_hr><title_en><![CDATA[Higher order repeats and global repeat map for neandertal, human and chimpanzee genomes]]></title_en><user_id>5102</user_id><user_firstLast_name>Vladimir Paar</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2014-09</proposal_call><code>IP-2014-09-3626</code><acronim><![CDATA[NEAND_HUMAN_CHIMP]]></acronim><duration>01.06.2015 - 31.05.2019</duration><status>Završio</status><financ_value>88.526,11 eur</financ_value><scie_area_hr>Prirodne znanosti, Biomedicina i zdravstvo, </scie_area_hr><scie_area_en>Natural sciences, Biomedicine and health sciences, </scie_area_en><scie_field_hr>Biologija, Matematika, Fizika, Kemija, </scie_field_hr><scie_field_en>Biology, Mathematics, Physics, Chemistry, </scie_field_en><institution_hr><![CDATA[Hrvatska akademija znanosti i umjetnosti]]></institution_hr><institution_en><![CDATA[Croatian Academy of Sciences and Arts]]></institution_en><team_members_id>4004, 5356, 5282, 19031, </team_members_id><team_members_names><![CDATA[Matko Glunčić, Ines Vlahović, Marija Rosandić Pilaš, Ivica Martinjak, ]]></team_members_names><keywords_hr><![CDATA[nekodirajuća DNK, genomski regulatori, repeticije višeg reda, globalna repeticijska mapa, genom čovjeka, genom čimpanze, genom neandertalca]]></keywords_hr><keywords_en><![CDATA[noncoding DNA, genomic regulators, higher order repeats, global repeat map, human genome, chimpanzee genome, neandertal genome, biological evolution]]></keywords_en><summary_hr><![CDATA[Istraživanje nekodirajuće DNA postaje bitno pitanje genomike zbog ključne uloge kao regulatora. Zato raste interes za primarne repeticije i repeticije višeg reda, s osobitom važnošću u medicini i evoluciji. Glavni cilj projekta je vrhunska identifikacija i opsežna mapa repeticija višeg reda (HOR) primjenom našeg originalnog izuzetno efikasnog i robusnog algoritma Globalne repeticijske mape (GRM) na genome neandertalca (nedavno sekvencioniran na Max Planck Inst. Evol. Anthropol. u Leipzigu) i čovjeka i čimpanze (iz datoteke NCBI, Bethesda). GRM algoritam temeljen je na novom matematičkom konceptu kompletnog ansambla stringova  Analizom repeticija može se dobiti uvid o evoluciji tih dinamički promjenjivih struktura čime GRM metoda postaje konkurentna na svjetskoj razini . Naši publicirani rezultati za egzemplarne slučajeve (&#39;&#39;case study&#39;&#39;) i inicijalne pilot studije su ohrabrujuće. Interdisciplinarni znanstveni ciljevi postići će se na dodiru genomike, bioinformatike, matematike, nelineane dinamike i naprednog računarstva. Za potrebe računanja na velikoj skali razvit ćemo naprednu verziju GRM programa primjenjivu u okružju cluster, grid i cloud kompjutinga. Ishodi projekta uključit će slobodni Katalog Globalnih Repeticijskih Mapa za HOR-ove triju primata (&#39;&#39;web based data based service&#39;&#39;), naprednu GRM verziju za korisnike, i radionice za trening stranih i domaćih mladih znanstvenika za korištenje naprednog GRM kompjutinga koji pruža superiorne mogućnosti primjene. GRM metoda u dosad istraženim slučajevima otkriva po prvi put u svijetu nove značajne korelacije koje se dosad nisu mogle otkriti postojećim algoritmima. Planirana je ativnost za povećanje vidljivosti ovih istraživanja i podstiče diseminacija jedinstvenih rezultata u međunarodnoj znanstvenoj zajednici, uključujući publiciranje u renomiranim međunarodnim časopisima, sudjelovanje na međunarodnim skupovima, i podsticanja međunarodne znanstvene suradnje.]]></summary_hr><summary_en><![CDATA[One of the key questions of modern genomics is the investigation of noncoding DNA because of possible important role as regulators. Thus of importance are complex repeats and higher order repeats, with potential significance in medicine and biological evolution. The main objective of the project includes the state-of-the-art identification of comprehensive map of higher order repeats (HORs), using our Global Repeat Map (GRM) algorithm for neandertal and NCBI assemblies of human and chimpanzee genomes. It will be of significant interest to discover how these dynamically changeable structures evolved, by analysis and comparison of similar repeats. Our initial published results and pilot studies are encouraging. The interdisciplinary scientific objectives will be achieved at interface between genomics, bioinformatics, mathematical methods, nonlinear dynamics and advanced scientific computing. For the need of large-scale studies in this project we will develop advanced version of our GRM program applicable on the environment of advanced computing and distributed calculations in cluster, grid and cloud cmputing at the Faculty of Science. Major project outcomes include free Catalogue of Global Repeat Maps for HORs with large secondary repeat units of three specieses (web-based database service), novel advanced GRM version for users and workshops for training foreign and domestic young researchers in the use of advanced GRM. Including M.Sc. and Ph.D students as co-workers will contribute to training of researchers in the early stages of research career and support transfer of know-how in the frontier of of computing methods. Activities are planned to increase visibility of the ongoing research and support dissemination of results to the international research community, including publications in international journals, contributions to international workshops and conferences, inviting guest scientists from abroad and initiating new international collaborations.]]></summary_en></project><project>
<id>3571</id><title_hr><![CDATA[Pametna okruženja za poboljšanje kvalitete života]]></title_hr><title_en><![CDATA[ELISE: Easy Living in Smart Environments]]></title_en><user_id>3685</user_id><user_firstLast_name>Mladen Russo</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2014-09</proposal_call><code>UIP-2014-09-3875</code><acronim><![CDATA[ELISE]]></acronim><duration>01.10.2015 - 30.09.2018</duration><status>Završio</status><financ_value>66.228,68 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Računarstvo, Elektrotehnika, </scie_field_hr><scie_field_en>Computer sciences, Electrical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Splitu, Fakultet elektrotehnike, strojarstva i brodogradnje]]></institution_hr><institution_en><![CDATA[University of Split, Faculty of Electrical Engineering, Mechanical Engineering and Naval Architecture]]></institution_en><team_members_id>7617, 7602, 7558, 7480, 20692, 21298, 18942, </team_members_id><team_members_names><![CDATA[Maja Stella, Matko Šarić, Marjan Sikora, Milan Ramljak, Ante Topić, Luka Kraljević, Goran Udovičić, ]]></team_members_names><keywords_hr><![CDATA[pametne okoline, nosiva sučeljam računalni vid, proširena stvarnost, prepoznavanje govora, prikupljanje energije iz okoline, lokalizacija, zv. kulise]]></keywords_hr><keywords_en><![CDATA[smart environments, wearable interfaces, computer vision, augmented reality, speech recognition, ambient energy harvesting, localization, soundscaping]]></keywords_en><summary_hr><![CDATA[Pametna okolina predstavlja svijet pun različitih senzora i pametnih uređaja koji neprimjetno rade skupa, čineći svakodnevni život lakšim i udobnijim. Projekt ELISE je zamišljen kao interdisciplinarni istraživački pristup usmjeren ka poboljšanju tehnologija na kojima se temelje pametne okoline, s ciljem uspostavljanja okvira za razvoj raznih real-life usluga i aplikacija u pametnim okolinama. Glavna područja istraživanja će uključivati senzore niske potrošnje i prikupljanje energije iz okoline, nosiva sučelja, prepoznavanje govora, računalni vid, prepoznavanje objekata i teksta, proširenu stvarnost, lokalizacijske tehnologije, zvučne kulise i auralizaciju. Svi članovi našeg interdisciplinarnog tima su visoko kvalificirani stručnjaci u tim područjima, budući da su već objavili doktorske disertacije i visoko kvalitetne radove u predloženim područjima istraživanja. Projekt će također doprinijeti obuci dva nova doktoranda omogućujući im odlične uvjete za njihova istraživanja. Istraživanja u svim područjima će se temeljiti na integriranom pristupu s vizijom razvoja real-life aplikacija u pametnoj okolini. Osobito dvije aplikacije će usmjeravati naš rad, te su planirane za izradu prototipa i demonstraciju u posljednjim fazama projekta: Smart sightseeing (Pametno razgledavanje) i Smart museum tour (Pametna tura muzejom). Temeljit će se na sučelju proširene stvarnosti (Augmented Reality – AR) na način da će se objekti od interesa automatski prepoznavati te omogućiti predstavljanje dodatnih sadržaju korisniku, također će biti opremljeni modulom za lokalizaciju, imati mogućnost poboljšanja AR pomoću zvučnih kulisa, biti upravljani pomoću govora i pametnih nosivih sučelja, npr. sučelje za prepoznavanje pokreta ruku, uz sposobnost detektiranja korisnikovih emocionalnih stanja i prilagođavanja sadržaja sukladno tome. Razvijeni moduli također će tvoriti osnovu za razvoj drugih aplikacija za lakši život u pametnim okolinama, uključujući domove, bolnice, ustanove za brigu o starijima i nemoćnima, uredima, gradovima...]]></summary_hr><summary_en><![CDATA[Smart environment represents a world full of different sensors and smart devices seamlessly working together, making everyday living easier and more comfortable. ELISE is envisioned as an interdisciplinary research approach aimed for improving the technologies on which smart environments are based, with the goal of establishing a framework for developing various real-life services and applications in smart environments. Primary areas of research will include low power sensing and ambient energy harvesting, wearable interfaces, speech recognition, computer vision, object and text recognition, augmented reality, localization technologies, soundscaping and auralization. All members of our interdisciplinary team have skills and experience in these areas since their PhD theses and published papers are directly related to the proposed research. ELISE will also contribute to the training of two new PhD students providing excellent conditions for their research. Research in all areas will be based on integrated approach with a vision of developing real-life smart environment applications. Particularly two applications will drive our work and are planned for prototyping and demonstration in the last stages of the project: smart sightseeing and smart museum tour. They will be based on augmented reality interface in a way that objects of interest are recognized in the scenes enabling presentation of additional content to the user, they will be equipped will localization module, have the ability of soundscape to enhance AR, be controlled via speech and wearable smart interfaces, e.g. hand gesture recognition interface, with the ability of detecting user&#39;s emotional states and adapting the content accordingly. Developed modules will also form the basis for developing other applications for easier living in smart environments, including homes, hospitals, care facilities, offices, cities...]]></summary_en></project><project>
<id>3575</id><title_hr><![CDATA[Istraživanje unosa joda u trudnoći i djetinjstvu u svjetlu nacionalne strategije prevencije poremećaja uzrokovanih nedostatkom joda ]]></title_hr><title_en><![CDATA[Investigation of iodine intake in pregnancy and childhood in view of national strategy for prevention of iodine deficiency disorders ]]></title_en><user_id>702</user_id><user_firstLast_name>Zvonko Kusić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2014-09</proposal_call><code>IP-2014-09-6499</code><acronim><![CDATA[IPACSTOPIDD]]></acronim><duration>22.09.2015 - 21.12.2019</duration><status>Završio</status><financ_value>105.819,30 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Javno zdravstvo i zdravstvena zaštita, Kliničke medicinske znanosti, </scie_field_hr><scie_field_en>Public health and health services, Clinical sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb School of Medicine]]></institution_en><team_members_id>5473, 5465, 6582, 5614, 5734, 6431, 4491, 6759, 5466, 5561, 6004, 5764, 5582, 4268, 5794, 5717, 13392, 6274, 6392, 6262, 6727, 6462, 260, 6314, 6196, 6697, 6476, 24169, 23652, </team_members_id><team_members_names><![CDATA[Tomislav Jukić, Josip Stanicic, Vesna Jureša, Roko Granić, Neven Mateša, Vera Musil, Marjeta Majer, MARINA PRPIĆ, MARIJA PUNDA, Nina Dabelić, Krunoslav Kuna, Dražena Krilić, Petra Petranović Ovčariček, Željka  Bukovec Megla, Valentina Vidranski, Maja Franceschi, ORJENA ŽAJA, Zlatko Topalović, Marijan Katalenić, Milan Vrkljan, Vedrana Gladić Nenadić, Ivan Mihaljević, ANA BARIĆ, Gordana Stipančić, Boris Bonefačić, Ivan Jakšić, Križo Katinić, Marija Bosak Butković, Ivan Blažeković, ]]></team_members_names><keywords_hr><![CDATA[unos joda, trudnice, djeca, jodiranje soli, prevencija, štitnjača]]></keywords_hr><keywords_en><![CDATA[iodine intake, pregnant women, schoolchildren, salt iodination, prevention, thyroid]]></keywords_en><summary_hr><![CDATA[Dostatan unos joda je od neprocjenjivog značaja za populaciju. Nedostatan unos joda uzrokuje brojne funkcijske i razvojne poremećaje od kojih je najvažnije zaostajanje u psihomotornom razvoju. Najosjetljivije skupine su trudnice i djeca. Hrvatska je u prošlosti bila područje s teškim nedostatkom joda uz pojavu kretenizma. Zbog prisutnosti blagog do umjerenog nedostatka joda, uveden je 1996. novi zakon o univerzalnom jodiranju soli (USI) s 25 mg kalij jodida po kilogramu soli, a kao rezultat, Hrvatska je postigla dostatan unos joda. Istraživanja provedena 2009. pokazala su dostatan unos joda u Hrvatskoj, ali je medijan joda u urinu školske djece bio u porastu, a granično nizak u trudnica. Istraživanjem će se procijeniti efikasnost programa USI kako bi se procijenilo je li zadovoljava potrebe za jodom u trudnica i školske djece. Pretpostavka je da program USI u Hrvatskoj zadovoljava potrebe za jodom u trudnica i djece, ali ne i u trudnica s ograničenim unosom soli. Istraživanjem će se obuhvatiti 1000 školske djece i 500 trudnica iz četiri glavne regije Hrvatske. U djece će se mjeriti jod u urinu, volumeni štitnjače ultrazvukom, jod u soli iz kućanstava i provesti uputnik. U trudnica će se mjeriti jod u urinu, volumeni štitnjače ultrazvukom, slobodni tiroksin tireotropin, tireoglobulin (Tg) i tireoiodna protutijela u serumu i provesti upitnik. Trudnice će biti podijeljene u četiri skupine s obzirom na ograničenje unosa soli i korištenje jodnih preparata. Vrijednost Tg-a u serumu kao biljega unosa joda u trudnoći biti će utvrđena uz definiranje medijana Tg-a koji određuje dostatan unos joda. Procjena preparata s jodom biti će učinjena s obzirom na sadržaj joda. Rezultati istraživanja omogućit će upravljanje programom USI, objavu smjernica za korištenje jodnih preparata u trudnoći,  provođenje mjera prevencije prekomjernog unosa joda regulacijom sadržaja joda u namirnicama i dodacima prehrani i utvrditi vrijednost Tg-a kao biljega unosa joda u trudnoći.]]></summary_hr><summary_en><![CDATA[Sufficient iodine intake is of the utmost importance for the population. Iodine deficiency (ID) has many adverse effects on growth and development, the most important being mental impairment in children. The most susceptible groups include pregnant women and children. In the past, Croatia was region of severe ID with presence of cretinism. Due to persistence of mild to moderate ID, new regulation on universal salt iodination (USI) was introduced in Croatia in 1996 with 25 mg potassium iodide per kg of salt, thus reaching iodine sufficiency. Investigations performen in 2009 confirmed iodine sufficiency. However, median urinary iodine concentration (UIC) in schoolchildren has been rising, while pregnant women had borderline sufficient median UIC. The study will assess iodine intake and monitor USI program to determine whether it provides sufficient iodine intake. The hypothesis is that USI program in Croatia provides sufficient iodine intake in pregnancy and schoolchildren except for pregnant women with salt restriction. A total of 1000 schoolchildren and 500 pregnant women from four regions of Croatia will be included in the investigation. Methods in schoolchildren comprise measurements of UIC, thyroid volumes by ultrasound (Tvol), iodine content in salt and questionnaire.  Methods in pregnant women comprise measurements of UIC, Tvol, serum FT4, TSH, thyroglobulin (Tg), thyroid antibodies and questionnaire. Pregnant women will be classified into four groups according to salt restriction and consumption of iodine rich supplements. Value of serum Tg as a marker of ID in pregnancy will be determined. Evaluation of iodine rich supplements  will be performed in relation to iodine content. The results of the study would enable USI program management and publication of guidelines regarding consumption of iodine rich supplements in pregnancy and to regulate  iodine content in food and supplements as well as assess the value of Tg as a biomarker of ID in pregnancy.]]></summary_en></project><project>
<id>3647</id><title_hr><![CDATA[Utjecaj endemskog ratovanja na zdravlje kasnosrednjovjekovnih i ranonovovjekovnih populacija Hrvatske]]></title_hr><title_en><![CDATA[]]></title_en><user_id>2788</user_id><user_firstLast_name>Mario Šlaus</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2015-10</proposal_call><code>DOK-2015-10-8678</code><acronim><![CDATA[Warandhealth]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Etnologija i antropologija, </scie_field_hr><scie_field_en>Ethnology and anthropology, </scie_field_en><institution_hr><![CDATA[Hrvatska akademija znanosti i umjetnosti]]></institution_hr><institution_en><![CDATA[Croatian Academy of Sciences and Arts]]></institution_en><team_members_id>19012</team_members_id><team_members_names><![CDATA[ Doktorand: Anita Adamić ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[physical anthropology, bioarchaeology, paleopathology, health, war, osteological analyses, medieval period, Croatia]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Warfare has afflicted humankind throughout its history, and is a phenomenon that still fundamentally affects the modern world. Despite the fact that violence -related mortality is profoundly undercounted, violent conflict represents the third most important source of mortality around the world. Analyzing the effects that war had on health through the deep time perspective that archaeological investigations afford can provide unique data on the interactions between warfare, health and the environment and provided conclusions that are particularly relevant to disadvantaged communities throughout the developing world where most wars are currently being fought. This project assembles an international and multidisciplinary team of collaborators to conduct bioarchaeological investigations on two large composite skeletal samples from Croatia. The two composite series represent individuals who inhabited Croatia throughout: a) the Late Medieval period (1100-1400 AD) a period of relative prosperity and peace prior to the arrival of Ottoman Turks, and b) individuals who inhabited Croatia in the Historic period (1400-1700 AD) during which time the Ottoman Empire gradually expanded into East and Central Europe. The research will reconstruct Historic period health, diet, weaning practices, and disease and trauma patterns by comparing them with data from the Late Medieval period using bioarchaeological, paleopathological and stable isotope analyses of human burials from Croatia. The project is a collaboration between researchers and postgraduate students who specialize in bioarchaeology, paleopathology, paleodemography, paleodontology, radiology and stable isotope analyses from four institutions: the Croatian Academy of Sciences and Arts, the School of Dental Medicine of the University of Zagreb, the Department of Diagnostic and Interventional Radiology of the University Hospital Dubrava, and the McDonald Institute for Archaeological Research of the University of Cambridge. ]]></summary_en></project><project>
<id>3648</id><title_hr><![CDATA[Supramolekulska kontrola fotokemijskih reakcija eliminacije]]></title_hr><title_en><![CDATA[]]></title_en><user_id>376</user_id><user_firstLast_name>Nikola Basaric</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2015-10</proposal_call><code>DOK-2015-10-3703</code><acronim><![CDATA[SupraPhotoE]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, </scie_field_hr><scie_field_en>Chemistry, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>24377</team_members_id><team_members_names><![CDATA[ Doktorand: Katarina Zlatić ]]></team_members_names><keywords_hr><![CDATA[fotokemija, supramolekulska kemija, karbeni, policikličke molekule, ftalimidi, kinon-metidi,]]></keywords_hr><keywords_en><![CDATA[photochemistry, supramolecular chemistry, carbenes, polycyclic molecules, phthalimides, quinone methides]]></keywords_en><summary_hr><![CDATA[Dinamika supramolekulskih sustava omogućava kontrolu fotokemijske reaktivnosti i otvara mogućnosti za reakcije koje se konvencionalnim postupcima sinteze, termičkim reakcijama u izotropnoj otopini ne mogu provesti. Glavna strategija predloženog projekta je primijeniti različite supramolekulske sustave za kontrolu fotokemijske reaktivnosti. Očekuje se da će predloženo istraživanjo povećati fundamentalna znanja iz supramolekulske kemije, fotofizike i fotokemije policikličkih molekula u izotropnim medijima i supramolekulskim kompleksima. Istraživanje će biti usmjereno na tri reakcije fotoeliminacije: eliminaciju dušika iz diazirina i diazo prekursora uz nastajanje karbena, fotodekarboksilaciju različitih derivata aktiviranih s ftalimidnim kromoforom i fotodehidrataciju i deaminaciju kojom nastaju kinon-metidni intermedijeri. Aspekti kojima ćemo se baviti su učinak molekulske geometrije na reaktivnost i konstantu stabilnosti inkluzijskih kompleksa, kao i utjecaj kompleksiranja na fotofizička svojstva različitih kromofora, učinkovitost fotokemijskih reakcija i raspodjelu produkata. U vezi s predloženim istraživanjem bit će neophodno provesti sintezu velikog broja molekula, dobro definirane i u nekim slučajevima i iznimno složene strukture, što će sigurno zahtijevati značajne inovacije u sintetskoj metodologiji i razvoju postojećih tehnika. Znanstveni ciljevi projekta će ići dalje od trenutnih spoznaja kroz potragu za bio-medicinskim primjenama. Nizu spojeva će biti ispitana antiproliferativna aktivnost, pri čemu će se odrediti &#39;&#39;lead&#39;&#39; spojevi za daljnja istraživanja i potencijalni razvoj liječenja raka uz minimalne nuspojave.]]></summary_hr><summary_en><![CDATA[Dynamics of the supramolecular systems facilitates control of the photochemical reactivity and opens opportunities for reactions which cannot be conducted by conventional synthetic methods, in the thermal reactions in isotropic solution. The main strategy of the proposed project is to apply different supramolecular systems to control photochemical reactivity. The proposed research should increase the fundamental knowledge in supramolecular chemistry, photophysics and photochemistry of the polycyclic molecules in isotropic media and the supramolecular complexes. The research will be focused on three photoelimination reactions: extrusion of nitrogen from diazirines and diazo precursors (giving carbenes), photodecarboxylation of different derivatives activated by phthalimides, and photodehydration and photodeamination giving quinone methide intermediates. The aspects which we will address include the effects of molecular geometry on reactivity and stability constants of the inclusion complexes, as well as influence of the complexation on the photophysical properties of different chromophores, efficiency of the photochemical reactions and product distribution. In connection with the proposed investigations it will be necessary to synthesize a large number of well defined and in some cases extremely complex molecules which will certainly ask for substantial innovations in the synthetic methodology and development of the existing techniques. The scientific goals of the project will go beyond the state of the art and search for bio-medical applications. A series of compounds will be screened for antiproliferative activity, providing lead molecules for further research and potential development of cancer treatment with minimal side effects.]]></summary_en></project><project>
<id>3651</id><title_hr><![CDATA[Satelitska DNA u genskoj regulaciji i ekološkoj adaptaciji]]></title_hr><title_en><![CDATA[]]></title_en><user_id>183</user_id><user_firstLast_name>Đurđica Ugarković</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2015-10</proposal_call><code>DOK-2015-10-4635</code><acronim><![CDATA[SatGenReg]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Biologija, </scie_field_hr><scie_field_en>Biology, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>21311</team_members_id><team_members_names><![CDATA[ Doktorand: Antonio Sermek ]]></team_members_names><keywords_hr><![CDATA[satelitska DNA, genska ekspresija, epigenetika, genska regulacija, adaptacija, Tribolium]]></keywords_hr><keywords_en><![CDATA[satellite DNA, gene expression, epigenetics, gene regulation, adaptation, Tribolium]]></keywords_en><summary_hr><![CDATA[Ponovljena DNA kao npr. transpozoni, može biti izvor regulatornih sekvenci te doprinijeti raspršenju regulatornih elemenata unutar eukariotskog genoma. Međutim, utjecaj na gensku regulaciju druge skupine vrlo zastupljenih, uzastopno ponovljenih sekvenci DNA kao što je satelitska DNA, nije do sada pokazan. U crvenom brašnaru Tribolium castaneum (Coleoptera) satelitska DNA igra važnu ulogu u regulaciji i remodeliranju heterokromatina tijekom razvoja i odgovora na vanjski stres. Ekspresija glavne satelitske DNA je jako potaknuta termičkim stresom, a povećana razina malih interferirajućih RNA (siRNA) koje potječu od satelitske DNA je praćena povećanjem represivnih epigenetskih modifikacija na histonima u heterokromatinu. Uz prisustvo u heterokromatinu, kratki odsječci satelitske DNA su raspršeni u blizini protein-kodirajućih gena u eukromatinu. Transkripcija glavne satelitske DNA osjetljiva na okolišne uvjete kao i njena raspršenost u susjedstvu gena upućuje na moguću ulogu satelitskih elemenata u regulaciji genske aktivnosti i adaptaciji na uvjete u okolišu.Cilj predloženog projekta je ispitati ulogu satelitske DNA u regulaciji aktivnosti gena u kukcu T. castaneum. Mi pretpostavljamo da siRNA koja potječe od satelitskih DNA utječe na epigenetski status dijelova eukromatina koji sadrže raspršene satelitske elemente na način da specifično navodi kromatinske modifikatore, primarno histonske metiltransferaze, na te regije. To može dovesti do nastanka heterokromatina na raspršenim satelitskim DNA elementima  i njegovog širenja na susjedna područja. Takova „heterokromatizacija“ može utjecati na ekspresiju susjednih gena, vjerojatno smanjujući njihovu aktivnost. Očekujemo da će naši rezultati po prvi put pokazati ulogu satelitskih DNA u podešavanju genske ekspresije i u ekološkoj adaptaciji.]]></summary_hr><summary_en><![CDATA[Repetitive elements such as transposons can be a source of regulatory sequences and could act to distribute regulatory elements throughout the genome. However, for the repetitive elements organized in tandem, known as satellite DNAs, role in gene regulation is not described till now. In the red flour beetle Tribolium castaneum (Coleoptera) satellite DNAs play an important role in heterochromatin regulation and remodelling during development and environmental stress response. Expression of a major satellite DNA is strongly induced by heat shock, and increased level of satellite-derived small interfering RNAs (siRNAs) is accompanied by increase of repressive epigenetic modifications of histones at heterochromatin. In addition to their presence in the heterochromatin, short stretches of satellite DNA have been mapped in the close vicinity of numerous genes within euchromatin. The environmentally susceptible transcription of a major satellite DNA as well as its distribution close to protein-coding genes provides strong support for the role of satellite DNA in gene regulation and adaptation to different environmental conditions.The aim of the proposed project is to investigate the gene-regulatory role of satellite DNAs in insect T. castaneum. We propose that satellite DNA-associated siRNAs could affect epigenetic state of euchromatic regions containing dispersed satellite elements by targeting these elements in a sequence-specific manner and by guiding chromatin modifiers, primarily histone methyltransferase. This could result in heterochromatin assembly at dispersed satellite DNA elements and its spreading to the flanking region. Such “heterochromatization” is expected to influence the expression of nearby genes, most probably by decreasing the level of gene expression. We expect that our results will for the first time demonstrate a role of satellite DNAs in the modulation of protein-gene expression and in environmental adaptation. ]]></summary_en></project><project>
<id>3653</id><title_hr><![CDATA[Višekomponentne reakcije u sintezi peptidnih mimetika]]></title_hr><title_en><![CDATA[]]></title_en><user_id>66</user_id><user_firstLast_name>IVANKA JERIĆ</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2015-10</proposal_call><code>DOK-2015-10-3082</code><acronim><![CDATA[MIMICRy]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, </scie_field_hr><scie_field_en>Chemistry, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>21264</team_members_id><team_members_names><![CDATA[ Doktorand: Mladena Glavaš ]]></team_members_names><keywords_hr><![CDATA[peptidomimetici, višekomponentne reakcije, makrociklički spojevi, neprirodne aminokiseline, ugljikohidrati, endiinski spojevi]]></keywords_hr><keywords_en><![CDATA[peptidomimetics, multicomponent reactions, macrocycles, non-natural amino acids, carbohydrates, enediyne compounds]]></keywords_en><summary_hr><![CDATA[Probir biblioteka malih molekula je najčešće korišten pristup u otkriću novih lijekova u posljednih dvadeset godina. Međutim, glavni nedostatak biblioteka je mala raznovrsnost bioloških i kemijskih svojstva spojeva koje sadrže, tj. biblioteke pokrivaju vrlo mali «kemijski prostor». U posljednjih 15 godina, svega 15 % novih kemijskih spojeva zapravo pripadaju novim klasama spojeva. To predstavlja glavnu zapreku razvoju novih vodećih spojeva potrebnih za istraživanje novih bioloških meta. Cilj ovog projekta je proširiti kemijski prostor novim spojevima koji imaju slične karakteristike kao i prirodni spojevi, korištenjem višekomponentnih reakcija. To ćemo postići: (a) razvojem novih gradivnih jedinica temeljenih na neprirodnim aminokiselinama, ugljikohidratima i endiinskim spojevima, (b) provođenjem Passerinijeve i Ugijeve reakcije za dobivanje raznovrsnih linearnih i cikličkih produkata i (c) proučavanjem stereokemije višekomponentnih reakcija.  	Rezultati projekta i znanje o metodologiji, stereokemiji i svojstvima novih spojeva značajni su za istraživanja u više područja: medicinska kemija (nove strukture za obogaćivanje biblioteka spojeva), razvoj katalizatora (posebno makrociklički spojevi s endiinskom jedinicoma) i biomedicinska istraživanja (spojevi s ugljikohidratnim strukturnim elementom mogu se koristiti kao biološke probe). Projekt je usklađen s ciljevima Hrvatske zaklade za znanost: razvoj konkurentnog istraživačkog okruženja i stvaranje novih znanja za jačanje hrvatskog gospodarstva. Rezultati projekta će biti temelj za stvaranje bibliteka sa strukturno različitim malim molekulama i makrocikličkim spojevima, kao odgovor na potrebe farmaceutske industrije: identifikacija još nepoznatih bioloških ciljeva i razvoj novih vodećih spojeva. Stoga projekt doprinosi i jednom od ključnih ciljeva u Europskoj uniji: poboljšanju zdravlja građana EU-a za povećanje bogatstva i dobrobiti ljudi. ]]></summary_hr><summary_en><![CDATA[Screening of small-molecule libraries has been the most commonly used tool in drug discovery over the past two decades. However, currently used libraries lack diversity in terms of biological and chemical properties, i.e. “chemical space” covered is infinitely small. In the past 15 years, only 15 % of the emerging novel chemical entities have been novel classes of compounds. This limitation significantly hampers development of novel lead compounds needed to tackle new generations of biological targets. The project goal is to expand the chemical space of natural product-like compounds by using multicomponent reactions. This will be achieved by: (a) developing novel non-natural amino acid-, carbohydrate- and enediyne-based building blocks; (b) performing Passerini and Ugi multicomponent reactions to obtain structurally diverse linear and macrocyclic compounds and (c) studying the stereochemistry of multicomponent reactions. Project results, and the knowledge about methodologies, stereochemistry and properties of novel compounds, are highly relevant for the following fields: medicinal chemistry - novel structures to fill the libraries; catalyst development – particularly enediyne-based macrocycles; and biomedical studies – carbohydrate-based compounds can be used as biological probes. Project is aligned with the goals of the Croatian Science Foundation: development of competitive research environment, and creation of new knowledge for the strengthening the Croatian economy. Project results will be the base for the generation of libraries with structurally diverse peptide-like small molecules and macrocyclic compounds, as an answer to the pharmaceutical industry needs: identification of yet undisclosed biological targets and the development of novel lead compounds. Therefore, project contributes to one the key objectives in the European Union: improving the health of EU citizens for generation of wealth and public wellbeing. ]]></summary_en></project><project>
<id>3654</id><title_hr><![CDATA[Uloga signalnog puta Wnt u epitelno-mezenhimskoj tranziciji]]></title_hr><title_en><![CDATA[]]></title_en><user_id>139</user_id><user_firstLast_name>Nives Pećina-Šlaus</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2015-10</proposal_call><code>DOK-2015-10-7672</code><acronim><![CDATA[WNT4EMT]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb School of Medicine]]></institution_en><team_members_id>19002</team_members_id><team_members_names><![CDATA[ Doktorand: Anja Bukovac ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[Wnt signaling, EMT, brain tumors, invasion, dishevelled, TCF/LEF]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[In the proposed research project we aim to determine the involvement of Dishevelled and TCF/LEF families of human genes in the process of Epithelial-to-Mesenchymal Transition (EMT) in brain tumors. We believe that the changes of structure and expression of the selected genes correlate with the phenotypic changes of tumor cells. EMT is a process very much involved in invasion and progression of tumors. Many oncogenic signaling pathways can induce EMT. The classical Wnt pathway has a particularly tight link with EMT and it has been shown that nuclear translocation of beta-catenin can induce EMT. Wnt pathway is one of the basic cellular pathways whose misregulation plays important roles in tumorigenesis and whose mediators of transcription are members of TCF/LEF family. Another important protein family is the Dishevelled considered to be the central hub of Wnt signaling since it interacts with Wnt receptors and recruits the multiprotein beta-catenin destruction complex. The experiments of the proposed research will use modern methods of molecular biology for the analyses of brain tumor samples of different malignancy grades. The genetic changes will be tracked by PCR/loss of heterozygosity, heteroduplex and Spreadex electorphoresis (Elchrom Scientific, Switzerland) methods. Expression of selected proteins will be studied by immunohistochemistry demonstrating their location in tumor cells. Besides its scientific value, results from the proposed project will have an application in medical diagnostics. Identifying changes in molecules responsible for control of cell motility will give us the preconditions for understanding the invasiveness of brain tumors and offer new disease progression markers. Our experimental evidence would also encourage the development of therapies that specifically interfere with Wnt signaling in cancer. ]]></summary_en></project><project>
<id>3655</id><title_hr><![CDATA[Aproksimacija ovisna o konfiguraciji u nelinearnoj analizi konstrukcija metodom konačnih elemenata]]></title_hr><title_en><![CDATA[]]></title_en><user_id>527</user_id><user_firstLast_name>Gordan Jelenić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2015-10</proposal_call><code>DOK-2015-10-1560</code><acronim><![CDATA[CANFAS]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Temeljne tehničke znanosti, </scie_field_hr><scie_field_en>Basic engineering sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Građevinski fakultet u Rijeci]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Civil Engineering]]></institution_en><team_members_id>22702</team_members_id><team_members_names><![CDATA[ Doktorand: Miran Tuhtan ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[non-linear structural analysis, finite-element method, configuration-dependent approximation, beams, shells, dynamics]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[This proposal explores the configuration-dependent interpolation as a novel, unorthodox and remarkably promising expansion of the framework within which the non-linear finite-element method has been traditionally contained. The basic idea underlying the project stems from an apparent disparity between the rather advanced extensions of the traditional linear finite-element principles to non-linear problems and the fact that the key finite-element concept – that of interpolation of the unknown functions – is surprisingly kept mostly constant, i.e. configuration-independent. Enabling the finite-element approximation to become configuration-dependent is motivated by the existing need to improve the current non-linear finite-element procedures, in particular for mechanical problems defined on non-linear manifolds. This principle is presented as the general concept providing viable novel development paradigm with obvious benefits for a wider class of mechanical problems. The configuration-dependent approximation to be designed shall obey the essential convergence requirements, with its extra flexibility (arising from the potential of the new approximation to vary with the configuration) employed to improve the solution in some clearly defined manner. In particular, during the design process, the following two basic principles will be consistently adhered to:(i) In the limiting case where the non-linear mechanical problem becomes linear, the configuration-dependent approximation sought must coincide with a known reference interpolation for linear analysis.(ii) In a general non-linear situation, the configuration-dependent approximation should preserve a set of selected mechanical or mathematical properties of equilibrium or motion defined beforehand.In this way, a variety of finite-elements for static and dynamic analysis will be derived.]]></summary_en></project><project>
<id>3656</id><title_hr><![CDATA[Istraživanje utjecaja otpadnih voda iz farmaceutskih industrija na sastav i profil antibiotičke rezistencije izloženih mikrobnih zajednica u slatkovodnim sedimentima]]></title_hr><title_en><![CDATA[]]></title_en><user_id>12566</user_id><user_firstLast_name>Nikolina Udiković Kolić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2015-10</proposal_call><code>DOK-2015-10-1635</code><acronim><![CDATA[WINAR]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Biotehnologija, </scie_field_hr><scie_field_en>Biotechnology, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>21182</team_members_id><team_members_names><![CDATA[ Doktorand: Milena Milaković ]]></team_members_names><keywords_hr><![CDATA[antibiotička rezistencija, mikrobne zajednice, farmaceutska industrija, otpadna voda, sediment, antibiotici, teški metali, rezistom]]></keywords_hr><keywords_en><![CDATA[antibiotic resistance, microbial communities, pharmaceutical industry, wastewater, sediment, antibiotics, heavy metals, resistome]]></keywords_en><summary_hr><![CDATA[Rastuća rasprostranjenost bakterija rezistentnih na antibiotike trenutno je jedna od najozbiljnijih prijetnji zdravlju. Istraživanja pokazuju da kontinuirani unos antibiotika i teških metala u okoliš doprinosi ovom problemu. Selekcijski pritisak nametnut od strane ovih zagađivala promovirao je razvoj i širenje antibiotičke rezistencije među okolišnim i patogenim bakterijama. Iako je otpad farmaceutske industrije prepoznat kao najvažniji točkasti izvor ovih zagađivala u prihvatnom vodenom okolišu, njegov utjecaj na sastav i profil antibiotičke rezistencije izloženih mikrobnih zajednica nije poznat. Kako bi popunili ovaj važan istraživački jaz, predlažemo primijeniti interdisciplinarni pristup koji će se fokusirati na slatkovodne sedimente koji su pod utjecajem otpadnih voda iz dviju lokalnih farmaceutskih industrija. Procijenit ćemo rasprostranjenost antibiotika i teških metala u tim sedimentima i identificirati potencijalne &#39;&#39;vruće točke&#39;&#39; za razvoj rezistencije. Geni koji kodiraju za antibiotičku rezistenciju porijeklom iz &#39;&#39;vrućih točaka&#39;&#39; i referentnih mjesta bit će otkriveni primjenom funkcionalne metagenomike. Ovaj pregled bit će osnova za kvantitativnu studiju koja će uspostaviti prostorno-vremensku poveznicu između industrijskog ispusta i zastupljenosti antibiotičke rezistencije. Ovi podaci, u kombinaciji sa hvatanjem rezistentnih plazmida direktno iz bakterija sedimenta u modelni patogen, bit će kritični za donošenje zaključaka o širenju rezistencije među bakterijama. Kompletno sekvenciranje mobilnih plazmida će nadalje pomoći u identifikaciji novih plazmida koji nose grupirane gene za rezistenciju na antibiotike i teške metale. Konačno, utjecaj ispusta na dinamiku sastava bakterijskih zajednica u sedimentima bit će analiziran Ilumina sekvenciranjem 16S rRNA gena. Vjerujemo da će dobivena saznanja imati vitalne implikacije na razvoj učinkovitih strategija upravljanja kako bi se smanjilo širenje antibiotika i antibiotičke rezistencije preko okolišnih puteva.]]></summary_hr><summary_en><![CDATA[The increasing prevalence of antibiotic resistant bacteria is currently one of the most serious health threats. There is growing evidence that continuous environmental discharge of antibiotics and heavy metals contributes to this issue. The selection pressure imposed by these pollutants has promoted the development and spread of antibiotic resistance among environmental bacteria and pathogens. Although pharmaceutical waste is recognized as the most important point source of these pollutants in the receiving aquatic environment, its impact on the composition and antibiotic resistance profile of exposed microbial communities is not known. To fill this important research gap, we propose to take an interdisciplinary approach focusing on freshwater sediments impacted by wastewaters of two local pharmaceutical industries. We will assess the prevalence of antibiotics and heavy metals in these sediments and identify potential hot spots for resistance evolution. Antibiotic resistance genes from hot spots and reference sites will be discovered using functional metagenomics. This will lay the groundwork for a quantitative study that will establish spatio-temporal relationships between industrial discharge and the occurrence of antibiotic resistance. This, in combination with direct capturing of resistance plasmids from sediment bacteria to a model pathogen will be critical to draw conclusions about the spread of resistance genes among bacteria. Complete sequencing of transferable plasmids will furthermore assist in identifying novel plasmids that carry clustered antibiotic and heavy metal resistance gene loci. Finally, the impact of discharge on dynamics of sediment community composition will be analyzed by Illumina sequencing of 16S rRNA genes. We believe that the obtained knowledge will have vital implications for the development of effective management strategies to reduce the spread of antibiotics and antibiotic resistance determinants via environmental pathways.]]></summary_en></project><project>
<id>3657</id><title_hr><![CDATA[Fizika Standardnog modela i njena proširenja]]></title_hr><title_en><![CDATA[]]></title_en><user_id>2665</user_id><user_firstLast_name>Blaženka Melić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2015-10</proposal_call><code>DOK-2015-10-6029</code><acronim><![CDATA[PhySMaB]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, </scie_field_hr><scie_field_en>Physics, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>21412</team_members_id><team_members_names><![CDATA[ Doktorand: Domagoj Leljak ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[theoretical particle physics,  Standard Model, perturbative calculations, physics beyond Standard Model, neutrinos]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[In high energy particle physics it is widely believed that the energy frontier experiments at LHC and the planned linear colliders, ILC and/or CLIC, together with ongoing and new experiments in neutrino and flavour physics will unravel fundamental problems in particle and astroparticle physics. A prerequisite for this progress is the complete understanding of the Standard model (SM) predictions. One of the triumphs of SM physics has been the extent to which QCD successfully describes strong interaction processes observed at colliders. More accurate QCD calculations are nowadays essential in understanding the enormous amount of available high-precision data, particularly since new physics effects are obscured by standard QCD processes. Our focus in that area will be to improve the description of hard exclusive processes by including higher-order contributions and by further developing the corresponding methods for automatic QCD calculations. Furthermore, we plan to do precision studies of top-quark production and decay observables which provide a unique view to the mechanism of electroweak symmetry breaking, important for understanding of particle mass generation. In the top-quark decay the information about its spin polarization imprinted by the production process is preserved, and can be calculated and measured in angular distributions of decay products providing other way to search for deviations from the SM expectations. Regarding new physics, the fact that neutrinos have a mass already requires an extension of the SM and calls for an understanding of the origin of neutrino masses. The seesaw mechanism, included in a theory as the one where left-right symmetry (parity) is restored at accessible LHC energies, stands out as a prominent theoretical candidate, and this theory links the origin of neutrino masses to new interactions at high energies and to the restoration of parity. A phenomenological investigation of these predictions is thus compelling and timely.]]></summary_en></project><project>
<id>3658</id><title_hr><![CDATA[Razumjevanje puta ulaska Adenovirusa tipa 26 u stanicu: način poboljšanja vektora za vakcinaciju]]></title_hr><title_en><![CDATA[]]></title_en><user_id>12819</user_id><user_firstLast_name>Dragomira Majhen</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2015-10</proposal_call><code>DOK-2015-10-1358</code><acronim><![CDATA[AdVEntPathVac]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Biologija, </scie_field_hr><scie_field_en>Biology, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>21250</team_members_id><team_members_names><![CDATA[ Doktorand: Davor Nestić ]]></team_members_names><keywords_hr><![CDATA[adenovirus tip 26, vektor, vakcinacija, unutarstanično putovanje, TLR, urođeni imunološki odgovor]]></keywords_hr><keywords_en><![CDATA[adenovirus type 26, vector, vaccination, intracellular trafficking, TLR, innate immune response]]></keywords_en><summary_hr><![CDATA[Adenovirusni  vektori imaju potencijalno translacijsku i komercijalnu vrijednost, a trenutno se istražuju kao vektori za prijenos DNA i vakcinu. Imunogeničnost adenovirusa tipa 26 (AdV26) značajno se razlikuje od drugih adenovirusnih vektora  što bi mu moglo dati  prednost pred ostalim adenovirusnim serotipovima u razvoju vakcina. Trenutno nema studija koje opisuju ulazak AdV26 u stanicu ističući potrebu za istraživanjem načina na koji AdV 26 inficira stanicu. U skladu s tim, ciljevi ovog projekta su istraživanje AdV26 receptora, vezanja i internalizacije AdV26 u ciljnu stanicu, AdV26 unutarstaničnog putovanja te urođenog imunološkog odgovora potaknutog infekcijom AdV26. Naši znanstveni ciljevi su novi i inovativni te usmjereni prema stvaranju novih znanja i rješenja kliničkih problema, a predložene metode koriste trenutno stanje tehnike. Ovim projektom uvodimo novo istraživanje u području adenovirusnih  vektora što našu grupu stavlja na uzbudljiv i vodeći rub istraživanja adenovirusa. Uspostavom ovog istraživanjanaša bi grupa postala dio mreže industrijsko-akademskog partnerstva u bazičnim i translacijskim istraživanjima adenovirusa u Europi što bi nam omogućilo ostvarivanje daljnjih suradnji i povećalo mogućnost dobivanja novih financiranja u budućnosti. Vjerujemo da će nova znanja koja će proizaći iz našeg istraživanja imati značajan utjecaj u području istraživanja  te biti od koristi kako akademskoj zajednici tako i industriji. Naša grupa, čije se osnivanje predlaže u ovom projektu, jedina je istraživačka grupa koja proučava bazičnu biologiju adenovirusnih vektora u Hrvatskoj čime se osigurava nastavak aktivnog istraživanja adenovirusa u Institutu Ruđer Bošković.]]></summary_hr><summary_en><![CDATA[Adenovirus (AdV) based vectors have potential translational and commercial values and are currently studied as vectors for DNA transfer and vaccination. Adenovirus type 26 (AdV26) has fundamental differences in immunogenicity from other AdV vectors, which might give it advantage over other AdV serotypes in vaccine vector development. To the best of our knowledge there are no reports describing AdV26 entry pathway underlining the need for studying infection pathway used by AdV26. Accordingly, the main objectives of this study are investigating AdV26 receptor usage, binding, internalization, intracellular trafficking and AdV26 mediated induction of innate immune response. Our scientific objectives are novel, innovative and designed to generate new knowledge and opportunities for therapeutic advances in areas of unmet clinical need. Our technical objectives use state-of-the-art, span academic and industrial specialties creating cross sector knowledge and long lasting inter-sectoral benefits. With this project we will introduce new line of AdV vector research in our group that would position us on the exciting and cutting edge of AdV research. Herewith we will become part of long lasting network of industrial–academic partnership in adenovirus basic and translational research across Europe granting lasting collaborations and increasing possibilities for obtaining new grants in the future. We believe that outputs of our research will have considerable impact on the field through gaining new knowledge from which both academia and industry will benefit. Our group, whose establishment is proposed in this project, is the only research group that studies basic biology of adenovirus vectors in Croatia and this grant proposal represents continuation of active adenovirus research in Ruđer Bošković Institute.]]></summary_en></project><project>
<id>3659</id><title_hr><![CDATA[Generalizirana geometrija i simetrije]]></title_hr><title_en><![CDATA[]]></title_en><user_id>52</user_id><user_firstLast_name>Larisa Jonke</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2015-10</proposal_call><code>DOK-2015-10-9750</code><acronim><![CDATA[GGSymm]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, </scie_field_hr><scie_field_en>Physics, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>22491</team_members_id><team_members_names><![CDATA[ Doktorand: Clay James Grewcoe ]]></team_members_names><keywords_hr><![CDATA[generalizirana kompleksna geometrija, nekomutativna geometrija, baždarne teorije, matrični modeli, fuzzy prostorir]]></keywords_hr><keywords_en><![CDATA[generalized complex geometry, non-commutative geometry, gauge theory, matrix models, fuzzy spaces]]></keywords_en><summary_hr><![CDATA[Ujedinjenje Einsteinove teorije opće relativnosti s kvantnom fizikom predstavlja jedan od najvećih izazova moderne teorijske fizike. Jedna pretpostavka zajednička svim istraživačkim smjerovima usmjerenih ka razumijevanja kvantne teorije gravitacije jest  da  za  opis geometrije prostor-vremena nije dostatna  klasična slika prostor-vremena kao diferencijabilne mnogostrukosti. U okviru ovog projekta smo zainteresirani za generalizirane geometrije motivirane fizikom teorije struna; generalizirana kompleksna geometrija i nekomutativna geometrija. Naš cilj jest  bolje razumijevanje  kako spomenute ideje generalizirane geometrije   iskoristiti u generalizaciji načela simetrije. Konkretno, zainteresirani smo za proširenje baždarnog principa, ključne ideje koji se koristi u fizici za opis svih (poznatih) međudjelovanja materije, a u svjetlu ovih proširenja klasične geometrije. Želimo opisati učinke dualnosti u teoriji struna, nekomutativne baždarne teorije te  viših baždarnih teorija u okviru učinkovne teorija polja koja nam je potrebne za obavljanje pouzdanih izračuna koje je moguće eksperimentalno provjeriti. Očekujemo da će nam geometrizacija ovih poopćenih simetrija pružiti, u dugogodišnjoj perspektivi, konzistentan okvir unutar kojeg bi se mogla riješiti neka od otvorenih pitanja u kozmologiji i fizici crnih rupa.]]></summary_hr><summary_en><![CDATA[The unification of Einstein&#39;s theory of general relativity with quantum physics represents one of the greatest challenges of modern theoretical physics. A hypothesis common to all research directions aiming at understanding the quantum theory of gravity is that our description of space-time geometry has to go beyond the classical picture of space-time as a differentiable manifold.  Within this project we are interested in generalized concepts of geometry, physically motivated by string theory: generalized complex geometry and non-commutative geometry. We aim at improving our understanding on how these generalized notions of geometry could be utilized to obtain consistent extensions of symmetry principles. In particular, we are interested in extending the gauge principle, the key physical notion used to describe all (known) matter interactions, in view of the above generalizations of classical geometry. Our goal is to capture the effects of string duality symmetries, non-commutative gauge theory and higher gauge theories at the level of the effective field theory description, which is necessary in order to perform reliable calculations and yield experimentally testable predictions. We expect that geometrizing these generalized symmetries would provide us, as a long-term perspective, with a consistent framework within which one could address open issues in cosmology and black-hole physics.]]></summary_en></project><project>
<id>3663</id><title_hr><![CDATA[Utjecaj magnetske anizotropije na kvantne spinske sustave]]></title_hr><title_en><![CDATA[]]></title_en><user_id>3184</user_id><user_firstLast_name>Tomislav Ivek</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2015-10</proposal_call><code>DOK-2015-10-3515</code><acronim><![CDATA[IMAQSS]]></acronim><duration>06.12.2016 - 05.12.2021</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, </scie_field_hr><scie_field_en>Physics, </scie_field_en><institution_hr><![CDATA[Institut za fiziku]]></institution_hr><institution_en><![CDATA[Institute of Physics in Zagreb]]></institution_en><team_members_id>21233</team_members_id><team_members_names><![CDATA[ Doktorand: Martina Dragičević ]]></team_members_names><keywords_hr><![CDATA[Kvantni spinski sustavi, niskodimenzionalni magneti, magnetska anizotropija, torque magnetometrija, elektronska spinska rezonancija]]></keywords_hr><keywords_en><![CDATA[Quantum spin systems, low-dimensional magnets, magnetic anisotropy, torque magnetometry, esr spectroscopy]]></keywords_en><summary_hr><![CDATA[Proučavanje magnetskih materijala donijelo nam je razumijevanje mnogih fizikalnih pojava te doprinijelo razvoju novih tehnologija. Magnetizam je kvantna pojava koja dolazi od interakcija superizmjene među magnetskim momentima u materijalu. Razumijevanje utjecaja tih interakcija na formiranje materijala sa specifičnim magnetskim svojstvima jedan je od glavnih problema u znanosti o materijalima. U niskodimenzionalnim kvantnim spinskim sustavima interakcije među spinovima su često opisane izotropnim Heisenbergovim hamiltonijanom. Eksperimentalni rezultati ukazuju na važnost slabih anizotropnih interakcija te zahtijevaju nova teorijska istraživanja. Te interakcije induciraju nove zanimljive pojave s velikim potencijalom za primjenu te je nalaženje novih metoda osjetljivih na njihovu detekciju od velike važnosti.Cilj ovog projekta je eksperimentalno istraživanje utjecaja magnetske anizotropije na odabrane kvantne spinske sustave kombinacijom dviju iznimno osjetljivih tehnika: torque magnetometrije i spektroskopske metode elektronske spinske rezonancije (ESR). Istraživat ćemo uzorke čiji magnetizam dolazi od spinova S=1/2, a koji se mogu klasificirati kao male spinske nakupine, kvazi-jednodimenzionalni Heisenbergovi antiferomagneti i/ili magnetoelektrici. Kombinacija spomenutih tehnika dat će novu metodologiju za istraživanje utjecaja magnetske anizotropije na kvantne spinske sustave i druge magnetske materijale te doprinijeti razumijevanju pojava induciranih magnetskom anizotropijom.U ovom projektu ostvarit će se suradnja između fizičara i kemičara sa svrhom sinteze novih visokokvalitetnih magnetskih materijala. Istraživanja će biti fokusirana na te materijale i na uzorke dobivene iz inozemnih ekspertnih laboratorija. Glavni cilj ovog projekta je formiranje nove istraživačke grupe s ekspertizom u istraživanju pojava induciranih anizotropijom u novim magnetskim materijalima.]]></summary_hr><summary_en><![CDATA[Study of magnetic materials provides us with understanding many of physical phenomena and continues to provide us with new technologies. Magnetism is a quantum phenomenon emerging from the superexchange interactions between magnetic moments in the material. Understanding how these interactions bring forth a material with specific magnetic properties is one of the key questions in materials science. In low-dimensional quantum spin systems the interactions between the spins are often described by the isotropic Heisenberg Hamiltonian. The importance of weak anisotropic interactions emerges from experiments and requires new theoretical treatments. These interactions are found to induce new interesting phenomena with great potential for applications in emerging technologies. Exploiting new methods sensitive to these interactions is thus crucial. Aim of this project is to experimentally investigate the influence of magnetic anisotropy on chosen quantum spin systems by combining two highly sensitive techniques: torque magnetometry and electron spin resonance (ESR) spectroscopy. Our study is focused on samples with magnetism coming from electron spin S=1/2, which can be classified as weakly interacting small spin clusters, quasi one-dimensional Heisenberg antiferromagnets and/or magnetoelectrics. The combination of mentioned techniques allows a new methodology for investigation of the influence of magnetic anisotropy on quantum spin systems and other magnetic materials and will provide important input in understanding of anisotropy induced phenomena.Within this project a collaboration between physicists and a chemist will be established with the purpose of synthesising new high-quality magnetic materials. Our study will focus on these materials, and on samples synthesized in expert laboratories abroad. The main aim of this project is to form a new independent research group highly qualified to investigate the anisotropy induced phenomena in new promising magnetic materials.]]></summary_en></project><project>
<id>3664</id><title_hr><![CDATA[Novi metodološki pristup biogeokemijskim istraživanjima specijacije metala u tragovima u obalnim vodenim ekosustavima]]></title_hr><title_en><![CDATA[]]></title_en><user_id>12557</user_id><user_firstLast_name>Dario Omanović</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2015-10</proposal_call><code>DOK-2015-10-4500</code><acronim><![CDATA[MEBTRACE]]></acronim><duration>10.10.2017 - 10.11.2021</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, </scie_field_hr><scie_field_en>Chemistry, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>23224</team_members_id><team_members_names><![CDATA[ Doktorand: Saša Marcinek ]]></team_members_names><keywords_hr><![CDATA[metali u tragovima, specijacija, obalni vodeni ekosustavi, modeliranje,  sedimenti, zagađivala]]></keywords_hr><keywords_en><![CDATA[trace metals, speciation, coastal aquatic ecosystems, modeling, sediments, contaminants]]></keywords_en><summary_hr><![CDATA[Predloženo istraživanje ima za cilj razjasniti nekoliko pitanja vezanih za fizičko-kemijske procese koji reguliraju ponašanje tragova metala (TM) u čistim, ali i u potencijalno zagađenim prijelaznim i priobalnim vodenim ekosustavima. Pokretljivost, reaktivnost kao i bioraspoloživost MT-ova jako ovise o njihovoj kemijskoj specijaciji, bez obzira imaju li ulogu mikronutrijenata ili  su izrazito toksični za organizme.Naša istraživanja usmjerena prema karakterizaciji međusobnog odnosa TM-ova s ostalim makro i mikro konstituentima prirodnih voda, posebno s prirodnom organskom tvari, bit će temeljena na korištenju najnovijih elektrokemijskih i složenih spektrometrijskih tehnika za specijaciju metala. Orijentirat ćemo se naročito na razvoj i usavršavanje metoda za specijaciju, mjernih protokola i mjernih senzora. Modele raspodjele metala razvijene u laboratorijskim uvjetima ispitat ćemo na uzorcima prirodne vode, a primijenit ćemo ih i kod on-site i in-situ mjerenja. Istraživanja će voditi do uspostavljanja niza specifičnih fizičko-kemijskih parametara, procedura i kriterija koja će omogućiti pouzdanu procjenu aktualnog stanja ali i predviđanje budućeg ponašanja TM-ova (specijaciju, mobilnost, biodostupnost/toksičnost) u slučaju lokalnih okolišnih nezgoda (npr. zagađenja) ili globalnih prijetnji (npr. “ocean acidification”).Istraživanja će se provoditi u vodnim područjima raznolikog kemijskog sastava gdje se očekuju promjene fizičko-kemijskih oblika TM-ova (As, Cd, Co, Cr, Cu, Fe, Hg, Ni, Pb, Zn), a uključivat će estuarijska, oksično/anoksična, eutrofička, te čista i zagađena područja, u kojima će se istraživati procesi koji se odvijaju kako na granicama faza, tako i u vodenom i sedimentnom stupcu.Teme istraživanja odabrane su tako da rezultati projekta budu od koristi ne samo široj znanstvenoj zajednici koja radi na problemima specijacije TM-ova nego i institucijama ovlaštenim za upravljanje priobalnim područjima.]]></summary_hr><summary_en><![CDATA[The proposed research aims at elucidating several issues related to the physico-chemical processes governing trace metals (TM) behaviour in pristine, but also in potentially contaminated transitional and coastal aquatic ecosystems. Whether the TMs behave as micronutrients or are highly toxic to organisms, their mobility, reactivity as well as bioavailability, strongly depends on chemical speciation.Our focus will be directed towards characterisation of interactions of TM with other macro and micro constituents of natural waters, particularly with natural organic matter, by employing the most recent approaches utilizing electrochemical and hyphenated spectrometric techniques. Particular effort will be invested in the development and improvement of speciation methods, measurement protocols and sensing electrodes. Methodologies developed under controlled laboratory conditions will be verified using natural water samples and applied in on-site and in-situ field-studies. The research will lead to the establishment of sets of specific measures and criteria which will allow reliable estimation of the actual state, but also the prediction of future behaviour of TMs (speciation, mobility, bioavailability/toxicity) in case of local environmental accidents (e.g. contamination) or global threats (e.g. ”ocean acidification”).Aquatic environments characterized by a variety of chemical compositions will be studied. In such conditions, variations in physical-chemical forms of the studied TMs (As, Cd, Co, Cr, Cu, Fe, Hg, Ni, Pb, Zn) are expected to occur. Study sites will be estuarine, oxic/anoxic, eutrophic and clean/contaminated areas, in which processes occurring at the phase boundaries, as well as in the sediment and water column will be explored.The specific subjects of the research are selected in a way to enable the outcome of the project be valuable not only to the broad scientific community working on TM speciation, but also to the authorities managing coastal zones.]]></summary_en></project><project>
<id>3666</id><title_hr><![CDATA[Novo poglavlje u procesima prijenosa naboja u vodenim otopinama]]></title_hr><title_en><![CDATA[]]></title_en><user_id>521</user_id><user_firstLast_name>Ivan Ljubić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2015-10</proposal_call><code>DOK-2015-10-5919</code><acronim><![CDATA[CTPAMR]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, </scie_field_hr><scie_field_en>Chemistry, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>21411</team_members_id><team_members_names><![CDATA[ Doktorand: Ivana Nikšić-Franjić ]]></team_members_names><keywords_hr><![CDATA[Radijacijska kemija, Kvantna kemija, Molekulska dinamika, Reakcijski mehanizam, Kinetika, Vodena otopina, Spregnuti prijenos protona i elektrona ]]></keywords_hr><keywords_en><![CDATA[Radiation chemistry, Quantum chemistry, Molecular dynamics, Reaction Mechanism, Kinetics, Aqueous solution, Proton-coupled electron transfer]]></keywords_en><summary_hr><![CDATA[Procesi prijenosa naboja u vodenom mediju od iznimnog su interesa zbog svoje ključne uloge u biokemiji i dizajnu sustava za pretvorbu energije. Unatoč opsežnim dugogodišnjim istraživanjima, načini prijenosa naboja i njihova ovisnost o reakcijskim uvjetima još su uvijek nedovoljno poznati. Sinergijskom kombinacijom eksperimentalnih i računskih pristupa nadamo se ostvariti značajan napredak u razumijevanju mehanizama i kinetike prijenosa naboja u reakcijama slobodnih radikala u vodenom mediju, posebice spregnutog prijenosa protona i elektrona (PCET). Težište će biti na reakcijama alfa-hidroksialkilnih i alfa-aminoalkilnih radikala s halogeniranim organskim supstratima te ovisnost prinosa dehalogenacije o prisutnosti i svojstvima pufera. U sličnim uvjetima planiramo studirati i reduktivna svojstva atoma vodika, što potencijalno pruža fascinantnu mogućnost istraživanja najfundamentalnijih aspekata PCET procesa. Istraživanja će se provoditi gama-radiolizom puferiranih vodenih otopina i kvantitativnim mjerenjima vrste i prinosa nastalih produkata u kombinaciji s kvantno-kemijskim i dinamičkim računalnim metodama, kako u svrhu racionaliziranja eksperimentalnih rezultata tako i za usmjeravanje eksperimenata. Budući da je PCET u ovim sustavima popraćen lančanom reakcijom koja znatno povećava prinose dehalogenacije, namjeravamo iznaći najpovoljnije uvjete za usmjeravanje reakcije u PCET kanal, posebice u odnosu na kompetitivne kanale radikalske supstitucije i adicije. Uspješno ostvarenje ciljeva projektnog prijedloga bitno će pridonijeti rješavanju središnjeg problema kemije slobodnih radikala u vodenim otopinama, tj. na koji način dizajnirati reakcijske uvjete, primjerice pH te koncentracije reaktanata i pufera, kako bi se radikalska reakcija učinkovito usmjerila prema određenom reakcijskom kanalu i na taj način optimizirao prinos produkata.]]></summary_hr><summary_en><![CDATA[Charge transfer processes in aqueous media are of a huge and ongoing interest due to their vital role in biochemistry and energy conversion applications. Despite extensive body of research invested in these processes, various modes of charge transfer and dependence thereof upon the reaction conditions are still insufficiently understood. By a synergistic combination of experimental and computational approaches, we hope to make major advances in understanding of the mechanisms and kinetics of charge transfer in free radical reactions in aqueous media, particularly of the proton-coupled electron transfer (PCET). Our focus will be on the reactions of the a-hydroxyalkyl and a-aminoalkyl radicals with halogenated organic substrates, and how the product yields of such a radical-induced dehalogenation are influenced by several buffer systems. In the similar context, we also plan to study reductive properties of the hydrogen atom, which offers a fascinating prospect of exploring the PCET process at its most fundamental. The reactions will be incited by the g-radiolysis of buffered aqueous solutions, followed by the detection and quantitative measurement of the products. This will be accompanied by quantum-chemical and molecular dynamical calculations, both to help rationalize the experimental findings and to guide the experiments. Because the PCET in these systems is remarkably accompanied by a chain reaction that greatly enhances the dehalogenation yields, we intend to elucidate the favorable conditions for the PCET to occur, especially as opposed to the rival free radical substitution and addition. A successful accomplishment of the objectives will be instrumental for resolution of the central problem in the aqueous chemistry of free radicals, and that is how to rationally design the specific reaction conditions, e.g. pH, reactant and buffer concentrations, in order to steer a free-radical induced reaction and optimize the yield due to a desired reaction channel.]]></summary_en></project><project>
<id>3668</id><title_hr><![CDATA[Novi enološki postupci kao alternativa sumporovom dioksidu u proizvodnji visokokvalitetnih vina]]></title_hr><title_en><![CDATA[]]></title_en><user_id>6224</user_id><user_firstLast_name>Karin Kovačević Ganić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2015-10</proposal_call><code>DOK-2015-10-5064</code><acronim><![CDATA[LOWSULF-HQWINE]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Prehrambena tehnologija, </scie_field_hr><scie_field_en>Food technology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prehrambeno-biotehnološki fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Food Technology and Biotechnology]]></institution_en><team_members_id>21313</team_members_id><team_members_names><![CDATA[ Doktorand: Katarina Lukić ]]></team_members_names><keywords_hr><![CDATA[Vino, SO2, antimikrobno djelovanje, kvaliteta vina, ultrazvuk visokog intenziteta (HPU), visoki hidrostatski tlak (HHP), hladna plazma (NTP)]]></keywords_hr><keywords_en><![CDATA[wine, SO2, antimicrobial activity, wine quality, high power ultrasound (HPU), high hydrostatic pressure (HHP) and non-thermal plasma (NTP)]]></keywords_en><summary_hr><![CDATA[Suvremeni zahtjevi za povećanjem sigurnosti i kvalitete vina utjecali su na preporuke o smanjenju, ali i na nove zakonske restrikcije u upotrebi sumporovog dioksida. Naime, zbog svojih antimikrobnih i antioksidacijskih karakteristika, sumporov dioksid jedan je od najučinkovitijih aditiva u proizvodnji vina. Međutim, uslijed potencijalnih pseudo-alergijskih reakcija koje kod osjetljivih pojedinaca dovode do zdravstvenih problema, korištenje sumporovog dioksida danas je pod razmatranjem. Stoga su i znanstvena istraživanja u posljednjem desetljeću intenzivno usmjerena na pronalaženje alternativa sličnih antiseptičkih i antioksidacijskih svojstava, kojima bi se zamijenila/smanjila upotreba sulfita u proizvodnji vina; što i danas predstavlja jedan od najznačajnijih enoloških izazova. U posljednje vrijeme, tehnologije kao ultrazvuk visokog intenziteta (HPU), visoki hidrostatski tlak (HHP) te hladna plazma (NTP) otvorile su nove mogućnosti u kontroli mikrobiološke kvalitete hrane te su stoga našle sve veću primjenu u prehrambenoj industriji. Međutim, primjena ovih novih, netermalnih postupaka u proizvodnji vina i njihov utjecaj na mikrobiološku stabilnost vina do sada nije istražen. Cilj projekta je istražiti mogućnosti primjene HPU, HHP i NTP sa svrhom smanjenja upotrebe sumporovog dioksida u proizvodnji visokokvalitetnih crnih, bijelih i desertnih vina. Ispitat će se utjecaj ovih netermalnih postupaka na cjelokupnu kvalitetu vina, u prvom redu na sastav polifenola, arome te senzorske karakteristike vina. Također, istražit će se mogućnosti ovih postupaka u kontroli mikrobiološke stabilnost vina. Nadalje, ispitat će se i sinergijski učinak navedenih postupaka te dodatka antioksidansa (niži udio sumporovog dioksida i glutation) tijekom dozrijevanja vina u bocama. Rezultati ovog projekta pokazat će kako primjenom novih netermalnih tehnologija samostalno ili u kombinaciji s antioksidansima proizvesti vina poboljšane kvalitete s nižim udjelom sumporovog dioksida.]]></summary_hr><summary_en><![CDATA[Modern increasing requirements for wine safety and quality led to very restrictive legislation regarding sulfur dioxide addition recommending limitations or even complete suppressing. In fact, sulfur dioxide is one of the most efficient additives used in winemaking due to its antimicrobial and antioxidant properties. However, as a result of potential pseudo-allergenic health problems in sensitive individuals use of sulfur dioxide has recently come under the review. Hence, in recent decades, alternatives to reducing/replacing sulfites in winemaking have been extensively studied. However, finding promising substitutes with similar antiseptic and antioxidant characteristics still remains major challenge. Recently, emerging technologies such as high power ultrasound (HPU), high hydrostatic pressure (HHP) and non-thermal plasma (NTP) have entered the field of food science and technology offering, as novel tools, new opportunities for managing food microbiology. Their opportunities in wine microbiology have not been examined. The aim of this project is to study the potential usage of HPU, HHP and NTP in production of high quality red, white and dessert wine as sulfur dioxide reducing strategies, and furthermore to optimize their application. Impact on overall wine quality, particularly chemical and sensory characteristic will be studied. Possibilities of these new technologies in controlling microbiological stability of wine will be investigated. In addition, synergistic practices of these physical technologies with antioxidants (lower content of sulfur dioxide and glutathione) during long period of aging in the bottles will be studied. The results of this project are expected to provide information how application of new physical technologies on its own or in combination with antioxidant addition can lead to wines with lower levels of sulfur dioxide and improved quality.]]></summary_en></project><project>
<id>3669</id><title_hr><![CDATA[Optomehanika uzrokovana frekventnim češljem]]></title_hr><title_en><![CDATA[]]></title_en><user_id>5410</user_id><user_firstLast_name>Ticijana Ban</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2015-10</proposal_call><code>DOK-2015-10-2389</code><acronim><![CDATA[MeCombO]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, </scie_field_hr><scie_field_en>Physics, </scie_field_en><institution_hr><![CDATA[Institut za fiziku]]></institution_hr><institution_en><![CDATA[Institute of Physics in Zagreb]]></institution_en><team_members_id>22599</team_members_id><team_members_names><![CDATA[ Doktorand: Neven Šantić ]]></team_members_names><keywords_hr><![CDATA[optomehanika, frekventni češalj, optička šupljina, spektroskopija, koherencija, hladni atomi, rubidij, magneto-optička zamka (MOT), dipolna zamka]]></keywords_hr><keywords_en><![CDATA[optomechanics, frequency comb, optical cavity, spectroscopy, coherence, cold atoms,rubidium, magneto-optical trap (MOT), optical dipole trap]]></keywords_en><summary_hr><![CDATA[Sila na atome uzrokovana kontinuiranim (eng. continuous wave, cw) laserima predstavlja centralni dio istraživanja u području atomske fizike već zadnjih nekoliko desetljeća. Radijativna sila čini osnovu za lasersko hlađenje i zarobljavanje atoma, čime je omogućeno stvaranje dovoljno gustih i hladnih atomskih uzoraka. Ipak, unatoč opsežnom i dobro shvaćenom području optomehanike uzrokovane cw laserom, istraživanja sila na atome uslijed interakcije s nizom ultrakratkih pulseva (odnosno frekventnim češljem) su oskudna. U međuvremenu, rezultati istraživanja provedenih u našoj grupi ukazuju na to da se, u specifičnoj geometriji pobude atoma frekventnim češljem, javljaju posve novi fenomeni koji zahtjevaju dodatna eksperimentalna i teorijska istraživanja.  Cilj ovog projekta je istraživanje novih fenomena koji se javljaju uslijed dijelovanja sile na atome uzrokovane frekventnim češljem (FC), a uključuje fenomene sprezanja i dekoherencije, stvaranja dipolne zamke s fs laserima u blizini atomske rezonancije te hlađenje atoma u optičkoj šupljini (rezonatoru) uzrokovano FC-om. Predložena istraživanja otvorit će nekoliko intrigantnih tema u području istraživanja koje je relevantno znanstvenoj zajednici širom svijeta. Predloženi će projekt utjecati na podizanje prepoznatljivosti hrvatske znanosti u svijetu, zapošljavanje i usavršavanje mladih istraživača i jačanje kapaciteta Instituta za fiziku putem međunarodne suradnje.]]></summary_hr><summary_en><![CDATA[Inducing mechanical action on atoms by continuous wave (cw) laser excitation has been a central topic in atomic physics for decades. Yet, in contrast to the rich and fruitful field of cw-laser-induced optomechanics, the investigations of mechanical action on atoms due to interaction with trains of ultrashort laser pulses (i.e. frequency combs) are scarce in literature. Meanwhile, recent results made in our group have indicated that in a specific excitation geometry an entirely new type of FC-atom interaction emerges that calls out for further experimental and theoretical investigation.The aim of the project is to explore novel phenomena that arise when the mechanical action on cold atoms is induced by frequency comb (FC) excitation, including entanglement and decoherence, near-resonance dipole trap, and frequency-comb-induced cavity cooling. The proposed research will open up several intriguing topics in the field of research that is relevant to the scientific community worldwide.The proposed project will increase the visibility of Croatian science, employ and educate young researchers and strengthen the capacity of the Institute of Physics through international cooperation.]]></summary_en></project><project>
<id>3670</id><title_hr><![CDATA[Primjena nusproizvoda prehrambene industrije za razvoj funkcionalnih i okolišno prihvatljivih ekstrudiranih proizvoda i aditiva ]]></title_hr><title_en><![CDATA[]]></title_en><user_id>5093</user_id><user_firstLast_name>Jurislav Babić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2015-10</proposal_call><code>DOK-2015-10-8207</code><acronim><![CDATA[FUNEXFOOD]]></acronim><duration>03.10.2016 - 03.10.2020</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Prehrambena tehnologija, </scie_field_hr><scie_field_en>Food technology, </scie_field_en><institution_hr><![CDATA[Sveučilište Josipa Jurja Strossmayera u Osijeku, Prehrambeno-tehnološki fakultet]]></institution_hr><institution_en><![CDATA[Josip Juraj Strossmayer University of Osijek, Faculty of Food Technology]]></institution_en><team_members_id>22630</team_members_id><team_members_names><![CDATA[ Doktorand: Marijana Grec ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[Functional food, extrusion, cereals, flours, by-products, environment-friendly]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Consumers nowadays are seeking palatable food which has beneficial effect on health. At the same time, they are not ready to change their eating habits – reduce intake of bakery products, fast food etc. and increase intake of fresh fruit and vegetable, whole grain products etc. Therefore, food industry is challenged to create products that are consumed every day (bread, snacks etc.) by large population, which are both enriched with bioactive substances and have desired sensory properties.The aim of this project is to develop new functional and enriched products based on extrusion process. Enriched grains (wheat, maize) will be used as basic material. The improvement and supplementation with biologically active (antioxidants, minerals, vitamns, fibre) will be done by addition of by-products from food industry (fruit and vegetable pomaces, oil cakes) in extrusion process. Extrusion will be used to produce final products: expanded snack products and pasta, as well as modified flours which will be used in production of bakery products and biscuits.All processes - extrusion of snack products and pasta, extrusion for flour modification, pasta drying, baking) will be optimised using response surface methodology. All products will be tested for chemical, physical, thermophysical properties, and optimal products will be sensory analysed.The results of project will be array of flours and final products with defined recipes and optimal production conditions, along with defined application of food industry by-products that significantly load environment and are not currently exploited to satisfying extent.In the project multidisciplinary approach will be applied – from agronomist, over food technologist and process engineers to sensory experts. In addition, close academia-industry links will be developed through different activities.]]></summary_en></project><project>
<id>3671</id><title_hr><![CDATA[Nuklearna struktura i reakcije: eksperimentima prema neutronskoj liniji kapanja]]></title_hr><title_en><![CDATA[]]></title_en><user_id>166</user_id><user_firstLast_name>Suzana Szilner</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2015-10</proposal_call><code>DOK-2015-10-4924</code><acronim><![CDATA[SR-ETNo]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, </scie_field_hr><scie_field_en>Physics, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>21302</team_members_id><team_members_names><![CDATA[ Doktorand: Petra Čolović ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[nuclear structure, nuclear reactions, neutron-rich nuclei, nucleon-nucleon correlations, nuclear pairing, nuclear clustering]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Understanding of atomic nuclei relies on knowledge about interaction between their components and details of their relationship. Recent advent of detector arrays allows systematic studies of nuclei away from the region of nuclear stability. With the proper selection of colliding systems and reaction energies, the exchange of nucleons can lead to the population of neutron-rich nuclei, peculiar systems having challenging aspects in their nuclear structure behaviour. The main objective of this research project is to advance understanding of the nuclear reactions and structure in the vicinity of the neutron drip line. By the use of the new generation instrumentation, we will experimentally study three different neutron-rich groups of nuclei: very heavy nuclei (difficult to access experimentally with other methods), medium-mass nuclei (where well known magic numbers disappear), and finally, lower mass nuclei (were the neutron drip line has already been experimentally reached). The major part of the proposed experimental work will be performed at the top international accelerator facilities, but in the well suited cases, the measurements will be performed at the RBI accelerator. The new experimental data will significantly improve our understanding of nuclei far from the stability line and will have a considerable impact on the reaction measurements at next generation of the radioactive beam facilities. Scientists involved in this project are active members of a number of  leading international collaborations in the field, with large experience in experimental research and considerable international reputation. Project PI has remarkable research track record and has led a successful project before. Senior scientists on the project have led a number of competitive projects (funded by MSES, FP7, ESF and Croatian SF). Finally, this project is well integrated with the strategic community document Long Range Plan of the Nuclear Physics European Collaboration Committee.]]></summary_en></project><project>
<id>3672</id><title_hr><![CDATA[Model rasta aneurizme temeljen na biokemijskim i mehaničkim podražajima ]]></title_hr><title_en><![CDATA[]]></title_en><user_id>1010</user_id><user_firstLast_name>Igor Karšaj</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2015-10</proposal_call><code>DOK-2015-10-3164</code><acronim><![CDATA[BCMModAneuGr]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Strojarstvo, </scie_field_hr><scie_field_en>Mechnical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet strojarstva i brodogradnje]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Mechanical Engineering and Naval Architecture]]></institution_en><team_members_id>19003</team_members_id><team_members_names><![CDATA[ Doktorand: Nino Horvat ]]></team_members_names><keywords_hr><![CDATA[aneurizma, abdominalna aorta, intraluminalni tromb, rast i promjena strukture, hiperelastičnost, naprezanja, prilagodba, razgradnja elastina, kolagen]]></keywords_hr><keywords_en><![CDATA[aneurysm, abdominal aorta, intraluminal thrombus, growth and remodeling, hyperelasticity, stress, adaptation, elastin degradation, collagen turnover]]></keywords_en><summary_hr><![CDATA[Modeliranje biokemijskih kao i mehaničkih promjena tijekom razvoja intraluminalnog tromba (ILT) ima potencijal da pomogne nam odgovoriti na pitanje kako dolazi do rasta aneurizme i što uzrokuje njenu rupturu. Konačni cilj ovog istraživanja je utvrditi promjene koje s javljaju rastom aneurizme. Simulirat ćemo od početnog krvnog ugruška pa kasnog stadija aneurizme promjera većeg od 5 cm. Pretpostavljamo da povećanje AAA je izravna posljedica razvoja ILT.  Predlažemo sljedeće ciljeve za ovaj projekt:Cilj 1: Razviti model rasta i promjene strukture fuziformne aneurizme koji je moguće koristiti u paketu za konačne elemente.Cilj 2: Potrebno je razviti trodimenzijski model rasta i promjene strukture sakularne aneurizme s uključenim intraluminalnim trombom.Cilj 3: Potrebno je ispitati različite hipoteze o tome kako dolazi do rupture ili stabilizacije AAA na realističnoj geometriji.Uspješno ostvarenje navedenih ciljeva bit će veliki napredak u polju biomehanike krvnih žila jer će omogućiti po prvi put praćenje kinetike razvoja intraluminalnog tromba unutar AAA i otkrivanje faktora koji utječu na rast i rupturu aneurizme.]]></summary_hr><summary_en><![CDATA[Proper biochemomechanical modeling of the development of an intraluminal thrombus (ILT) has the potential to help us answer the question about reasons for aneurysmal growth and to define parameters influencing potential for rupture?. The overall goal of this project, therefore, is to quantify the development of ILT from the initial blood clot to a mature formation, with special attention to changes in the clot structure. Our hypothesis is that AAA growth is a direct consequence of ILT development. We propose following aims for this proposal:Aim 1: To develop a finite element growth and remodeling model of thrombus-laden fusiform aneurysm from the moment of initiation.Aim 2: To develop a 3-D finite element growth and remodeling model of thrombus-laden saccular abdominal aortic aneurysm from the healthy aorta.Aim 3: To test different hypothesis on AAA rupture and stabilization on realistic geometry from Aim 2.Successful realization of these aims will advance the field of vascular mechanics by allowing for the first time quantification of kinetics of an intraluminal clot within AAA, and factors that significantly influence aneurysmal growth and risk of the rupture. ]]></summary_en></project><project>
<id>3673</id><title_hr><![CDATA[Računalna rješenja u bioznanostima: Značaj savitljivosti molekula]]></title_hr><title_en><![CDATA[]]></title_en><user_id>56</user_id><user_firstLast_name>Borislav Kovačević</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2015-10</proposal_call><code>DOK-2015-10-8556</code><acronim><![CDATA[CompSoLS-MolFlex]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, </scie_field_hr><scie_field_en>Chemistry, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>21421</team_members_id><team_members_names><![CDATA[ Doktorand: Luka Bilić ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[Molecular Flexibility, Computational Chemistry, Peptides, Proteins, Enzyme Catalysis]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Molecular flexibility controls a number of key processes ranging from protein folding to the design of advanced materials. However, the detailed understanding of its impact on a given process is poorly understood. Direct investigation of this phenomenon by experimental means, is a challenging endeavour, as the microscopic details are frequently hidden from macroscopic observations. Computational simulations, on the other hand, provide detailed information regarding molecular dynamics and flexibility. The theoretical approach is thus crucial in both understanding the experimental results and in expanding the underlying conceptual framework.The present project proposes to utilize state-of-the-art computational techniques to address the importance of molecular flexibility across a range of carefully selected examples from the life sciences. The examples, which can be classified under the headings: (i) peptides and spectroscopy, (ii) protein flexibility, and (iii) enzyme related transformations, have been chosen to span multiple time and length scales and thus to highlight the diverse and wide-reaching nature of molecular flexibility. The selected examples exhibit a significant degree complementarity and synergy with one another and are all associated with their own applicative importance in different areas of (bio)chemistry.In addition to the scientific research proposed, the project aims to consolidate a highly successful and competitive platform in computational life sciences that has been established at the RBI. This platform was already recognized through the granting of an EU-FP6 project (2007-2010). The current project team is thus well equipped for the proposed work and exhibits a good balance between senior researchers, with excellent track records, and junior scientists with outstanding potential. The support of the project team by HrZZ is crucial for maintaining their competitiveness in the international scientific environment of computational life sciences.]]></summary_en></project><project>
<id>3674</id><title_hr><![CDATA[EXploisives PrEcursor Defeat by Inhibitor Additives (EXPEDIA)]]></title_hr><title_en><![CDATA[]]></title_en><user_id>738</user_id><user_firstLast_name>MUHAMED SUĆESKA</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2015-10</proposal_call><code>DOK-2015-10-3871</code><acronim><![CDATA[]]></acronim><duration>01.08.2017 - 31.07.2021</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Kemijsko inženjerstvo, </scie_field_hr><scie_field_en>Chemical engineering, </scie_field_en><institution_hr><![CDATA[Ništa od navedenog]]></institution_hr><institution_en><![CDATA[Nothing from this list]]></institution_en><team_members_id>23265</team_members_id><team_members_names><![CDATA[ Doktorand: Barbara Štimac ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>3676</id><title_hr><![CDATA[Električni transport u staklima i staklo-keramici]]></title_hr><title_en><![CDATA[]]></title_en><user_id>4869</user_id><user_firstLast_name>Andrea Moguš-Milanković</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2015-10</proposal_call><code>DOK-2015-10-6510</code><acronim><![CDATA[EL-Trass-Ceram]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, </scie_field_hr><scie_field_en>Chemistry, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>21288</team_members_id><team_members_names><![CDATA[ Doktorand: Juraj Nikolić ]]></team_members_names><keywords_hr><![CDATA[Električni prijenos, staklo, staklo-keramika, elektronsko-ionska vodljivost, efekt &#39;&#39;miješanih&#39;&#39; staklotvoraca]]></keywords_hr><keywords_en><![CDATA[Electrical transport, glass, glass-ceramics, mixed ionic-electronic conductivity, mixed glass former effect]]></keywords_en><summary_hr><![CDATA[Izraženi zahtjevi suvremenih tehnologija za novim materijalima sa specifičnim svojstvima otvaraju velike mogućnosti u istraživanju stakala i staklo-keramike. Priprava novih stakala i staklo-keramika posebnih svojstava, istraživanje odnosa sastava stakla, strukture, električnih i termičkih svojstava posebno je važno za razumijevanje procesa koji se odvijaju u tim materijalima. Cilj je predloženog istraživanja priprava novih više-komponentnih fosfatnih stakala te određivanje odnosa između dvije osnovne vrste nositelja naboja, iona i elektrona, prisutnih u odabranim staklima i staklo-keramikama. Predloženi je projekt podijeljen na tri osnovna, međusobno povezana, koraka. 1. U prvom će se dijelu istraživati mehanizmi vodljivosti u fosfatnim staklima koja pokazuju „miješanu“ elektronsko-ionsku vodljivost. 2. Drugi dio uključuje istraživanje utjecaja „miješanih“ staklotvoraca na električne procese kod fosfatnih stakala.  3. U trećem će se dijelu istraživati utjecaj kontrolirane kristalizacije na električni prijenos u odabranim modelnim sustavima iz koraka 1 i 2. Nastajanje kristalnih zrna u staklenoj matrici može promijeniti električnu vodljivost i dielektična svojstva stakla. Temeljna je ideja projekta sustavno istraživanje koje će pridonijeti razumijevanju dinamike prijenosa naboja (iona i elektrona) u staklima i staklo-keramici s različitim udjelom kristalnosti (od potpuno amorfnih do potpuno kristaliziranih). Osnovni je cilj odrediti pokazuju li uvijek ionsko-elektronska stakla i stakla koja sadrže više staklotvoraca, efekt ionsko-elektronske vodljivosti odnosno efekt „miješanih“ staklotvoraca što predstavlja univerzalno obilježje.  Međudjelovanje staklotvoraca i modifikatora mreže te nastajanje veza među njima osnovni su čimbenici koji utječu na električna svojstva stakala. Osim što je istraživanje mehanizama vodljivosti u odabranim sustavima važno s akademskog gledišta, odabrani sustavi pokazuju široke mogućnosti u primjeni kao novi elektroliti.]]></summary_hr><summary_en><![CDATA[Considerable demands of modern technology for new materials with specific properties have raised many possibilities for the investigation of glasses and glass-ceramics. Preparation of new glass and glass-ceramics with characteristic properties and the investigation of relationships among compositions, structure, electrical and thermal properties are important for understanding the mechanisms involved in these materials. The objectives of the proposed research is to prepare novel multi-compositional phosphate-based glasses, determine the correlation among both types of charge carriers, ions and electrons, present in proposed systems. In order to accomplish this, the proposed project is divided into three main interrelated steps. 1. First part will be focused on the conduction mechanisms in phosphate-based glasses that exhibit mixed electronic-ionic conduction. 2. Second part includes study of the influence of the mixed glass former effect on electrical processes in phosphate-based glasses. 3. Third part involves study of the influence of controlled crystallization on electrical transport in selected model glasses from steps 1 and 2. The formation of crystalline grains  in a glass matrix can substantially change electrical conductivity and dielectric properties of glass. The idea is to perform systematic studies for understanding the charge transport (ion and electron) dynamics in glasses and glass-ceramics with different crystallinity (from fully amorphous to fully crystallized). The main aim is to determine the universality of the mixed electronic-ionic and mixed glass former effects in proposed glasses. The interactions between glass formers and modifiers, the formation of bonds among them are essential factors that influence the electrical properties of glasses. Beyond the connection to the central theme of conduction mechanism important from academic point of view, the selected systems are all associated with their multiple applications as advanced electrolytes.]]></summary_en></project><project>
<id>3678</id><title_hr><![CDATA[Multiferoični i magnetoelektrični sustavi]]></title_hr><title_en><![CDATA[]]></title_en><user_id>2787</user_id><user_firstLast_name>Damir Pajić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2015-10</proposal_call><code>DOK-2015-10-5107</code><acronim><![CDATA[FerMaEl]]></acronim><duration>01.06.2017 - 01.03.2022</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, </scie_field_hr><scie_field_en>Physics, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>22816</team_members_id><team_members_names><![CDATA[ Doktorand: Pavla Šenjug ]]></team_members_names><keywords_hr><![CDATA[multiferoici, magneto-električni učinak, metalni oksidi, metalo-organske mreže, magnetizacija, polarizacija, teorija funkcionala gustoće]]></keywords_hr><keywords_en><![CDATA[multiferroics, magneto-electric effect, metallic oxides, metal-organic frameworks, magnetization, polarization, density functional theory]]></keywords_en><summary_hr><![CDATA[Multiferoici su materijali u kojima istovremeno postoje i magnetsko i električno uređenje, što je važno i za temeljnu fiziku i za primjene, poglavito zbog mogućeg vezanja dvije vrste reda. Iako mnogi materijali pokazuju posredne znakove magneto-električnog vezanja, izravne eksperimentalne činjenice mogle bi unaprijediti naše znanje o mehanizmima vezanja i postojanja dva uređenja. Stoga bi nadogradnja postojećih SQUID i VSM magnetometara omogućujući istraživanje utjecaja električnog polja na magnetizaciju, kao i izgradnja instrumentacije za mjerenje električne polarizacije  u primijenjenom magnetskom polju unutar postojećih kriostata, otvorila široke mogućnosti za magneto-električno istraživanje multiferoika. Multiferoičnost se javlja u različitim skupinama materijala, a istraživanje će biti usmjereno na one obećavajuće. Nove metalo-organske mreže vrlo su perspektivne, te ćemo raditi na njihovoj sintezi i modifikacijama, radi razumijevanja i utjecanja na njihovo magneto- električno ponašanje. Također, ne-centrosimetrični miješani metalni oksidi, kao i njihove nanočestice, pružaju široke mogućnosti  sinteze i modifikacije multiferoičnih svojstava. Predloženo multidisciplinarno istraživanje rezultiralo bi novim spojevima i izgrađenom aparaturom za potpunu magnetsku i električnu karakterizaciju potrebnu pri istraživanju multiferoika, dajući cjelovit skup eksperimentalnih činjenica upotpunjenih detaljnim teorijskim računima. Zajednički rad doveo bi do razvoja nezavisne istraživačke karijere i nastanka nove istraživačke skupine, jačajući suradnju i izobrazbu. Sveukupno bi omogućila plodno okruženje za kompetitivnu uključenost u istraživanja na svjetskoj razini unutar te aktualne teme u fizici čvrstog stanja i znanosti o materijalima, okupljanjem ljudskih i drugih znanstvenih resursa oko proizvodnje novih multiferoičnih sustava te njihovog cjelovitog eksperimentalnog i teorijskog proučavanja.]]></summary_hr><summary_en><![CDATA[Multiferroics are materials where the magnetic and electric orders coexist, being important for fundamental physics and applications, especially due to possible coupling of the two orders. While many materials show the indirect signs of the magneto-electric coupling, the direct experimental evidences could still improve our knowledge about mechanisms of the coupling and coexistence of two orders. Therefore, the upgrade of the existing SQUID and VSM magnetometers enabling investigation of influence of the electric field onto the magnetization, and also build up of instrumentation for measurement of electric polarization in applied magnetic field, would open large possibilities for magneto-electric research of the multiferroics. Multiferroicity appears in different groups of materials and investigation would be focussed on especially promising. New metal-organic frameworks are very perspective, and we will be working on their synthesis and modifications, in order to understand and influence their magneto-electric behaviour. Further, non-centrosymmetric metallic oxides, as well as their nanoparticles, offer large possibilities for the synthesis and modification of multiferroic properties. Proposed multidisciplinary research would result with the novel compounds and installed equipment for complete magnetic and electric characterization needed in research of multiferroics, giving integral set of experimental results, supplemented with detailed theoretical calculations. Joint work would lead to development of the independent research careers and growth of new team, strengthening the collaboration and education. It would enable the fertile environment for the competitive involvement in the research at international level within this state-of-the-art topic of condensed matter physics and materials science, because of assembling the human and other scientific resources around production of the new multiferroic systems and their complete experimental and theoretical study.]]></summary_en></project><project>
<id>3681</id><title_hr><![CDATA[Genomski i glikanski biomarkeri PTSP-a]]></title_hr><title_en><![CDATA[]]></title_en><user_id>1306</user_id><user_firstLast_name>Nela Pivac</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2015-10</proposal_call><code>DOK-2015-10-8774</code><acronim><![CDATA[GlycoGenePTSD]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>22640</team_members_id><team_members_names><![CDATA[ Doktorand: Lucija Tudor ]]></team_members_names><keywords_hr><![CDATA[PTSP, N-glikani, epigenetika, GWAS, genetika]]></keywords_hr><keywords_en><![CDATA[PTSD, N-glycans, epigenetics, GWAS, genetics]]></keywords_en><summary_hr><![CDATA[Napredak u razumijevanju glikanskih funkcija i struktura može ponuditi nove biomarkere PTSP-a. Rezultati GWAS studija kombiniranih s metodama visoke djelotvornosti, kao što su analize fluorescentno obilježenih glikana, pokazali su da su geni B3GAT1, SLC9A9, MGA5, FUT8, FUT3/FUT6 i HNF1A povezani s glikozilacijom u zdravih osoba iz Hrvatske. Određivanje plazmatskih i IgG N-glikana u PTSP-u, dodatno korigiranih za mogući genetski i epigenetski utjecaj, poboljšat će naše razumijevanje biološke osnove PTSP-a. Cilj predloženog projekta je istražiti povezanost između genetskih, epigenetskih i glikomskih mehanizama odgovornih za otpornost ili ranjivost na razvoj PTSP-a nakon izlaganja traumatskom iskustvu/iskustvima.Specifični ciljevi projekta su:1) određivanje N-glikana u plazmi i IgG-u bolesnika s PTSP-om i odgovarajućih kontrolnih ispitanika;2) potvrda specifičnih polimorfizama odabranih gena koji reguliraju glikozilaciju proteina, određenih putem GWAS studija, u bolesnika s PTSP-om i odgovarajućih kontrolnih ispitanika;3) procjena utjecaja epigenetske regulacije i ekspresije gena HNF1A na glikozilaciju proteina u bolesnika s PTSP-om i odgovarajućih kontrolnih ispitanika.Ovakav pristup će ponuditi integraciju i razumijevanje multidimenzionalnih baza podataka i identificirati nove biomarkere PTSP-a, kao i nove mete i nove strategije u prevenciji razvoja PTSP-a nakon izlaganja traumi ili u terapijskoj intervenciji u PTSP-u.]]></summary_hr><summary_en><![CDATA[The advances in understanding of glycans’ function and structure might offer new biomarkers of PTSD. The results from GWAS, combined with high throughput analysis of fluorescently labelled glycans, suggest B3GAT1, SLC9A9, MGA5, FUT8, FUT3/FUT6 and HNF1A genes to be associated with glycosylation in healthy individuals from Croatia. Determination of N-glycans associated with PTSD in plasma and from IgG, additionally corrected for a possible genetic and epigenetic influence, will improve our understanding of the biological underpinnings of PTSD. The proposed project aims to provide an association between genetic, epigenetic and glycomic mechanisms responsible for the resilience or vulnerability to develop PTSD after exposure to a traumatic event(s).The specific aims of the project are:1) determination of plasma and IgG N-glycans in patients with PTSD and in matched control subjects;2) confirmation of the polymorphisms in the specific selected genes which regulate protein glycosilation, determined by GWAS, in patients with PTSD and in matched control subjects; 3) evaluation of the influence of epigenetic regulation and expression of the HNF1A gene on protein glycosylation in patients with PTSD and in matched control subjects.This approach will offer integration and understanding of the multidimensional dataset and identify novel biomarkers of PTSD, as well as new targets and novel strategies to prevent development of PTSD after exposure to a trauma, or for therapeutic intervention in PTSD.]]></summary_en></project><project>
<id>3684</id><title_hr><![CDATA[Univerzalne osobine sustava hladnih bozonskih i fermionskih atoma]]></title_hr><title_en><![CDATA[]]></title_en><user_id>875</user_id><user_firstLast_name>Leandra Vranjes Markic</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2015-10</proposal_call><code>DOK-2015-10-9336</code><acronim><![CDATA[UniCold]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, </scie_field_hr><scie_field_en>Physics, </scie_field_en><institution_hr><![CDATA[Sveučilište u Splitu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Split, Faculty of Science]]></institution_en><team_members_id>18947</team_members_id><team_members_names><![CDATA[ Doktorand: Krešimir Dželalija ]]></team_members_names><keywords_hr><![CDATA[ultrahladni plinovi, kvantni Monte Carlo, univerzalnost, nered, BEC, suprafluidnost, spin-orbit vezanje, kvantna halo stanja]]></keywords_hr><keywords_en><![CDATA[ultracold gases, Quantum Monte Carlo, universality, disorder, BEC, superfluid, spin-orbit coupling, quantum halo state]]></keywords_en><summary_hr><![CDATA[Ultrahladni plinovi nude besprimjerne mogućnosti proučavanja jako koreliranih sustava  i razmatranje izazova u različitim područjima fizike.  Pogodni su zbog podesivosti jačine  interakcija i mogućnosti kontroliranja i  istraživanja utjecaja dimenzionalnosti, neredai kvantne statistike. Omogućavaju eksperimentalno ostvarenje kako tradicionalnih modela fizike kondenzirane materije tako i novih sustava kao što su spin-orbit vezani (SOC) bozoni.Posebno su zanimljive njihove univerzalne osobine, koje omogućavaju uspostavljanje veza između fenomena na različitim skalama energije i duljine. Rezonantni režim s duljinom raspršenja jednakom nulipredstavlja univerzalnu jako interagirajuću unitarnu granicu, gdje su potrebna točna teorijska predviđanja koja uključuju efekte iznad teorije srednjeg polja. Kvantnim Monte Carlo(QMC) metodama moguće je točno riješiti višečestičnu Schrodingerovu jednadžbu za atome, molekule, tekućine, krutine i različite modele. U projektu ćemo dalje razviti metode te ih primijeniti na probleme sustava hladnih bozonskih i fermionskih atoma, s ciljem karakterizacije njihovih univerzalnih osobina. Prvo, proučit ćemo sustave malog broja čestica, fokusirajući se na realistična molekularna kvantna halo stanja, kao što su klasteri helija i alkalijskih atoma. Cilj je utvrditi mogu li se univerzalne relacije skaliranja  između energije i veličine sustava, već utvrđene na primjeru trimera, proširiti na sustave većeg broja čestica, što je važno  i za halo stanja u nuklearnoj fizici. Nadalje će se proučiti utjecaj nereda i dimenzionalnosti na univerzalne osobine bozonskih i bozonsko ferminskih mješavina u zamkama. Posebno zanimljiv je prijelaz između suprafluida i izolatora te lokalizacija suprafluidnosti i Bose-Einsteinove kondenzacije. Naposljetku, QMC metode ćemo dodatno razviti tako da uzimaju u obzir i spinove čestica, što će omogućiti proučavanje univerzalnosti i novih faza SOC plinova.                                                                                                                  ]]></summary_hr><summary_en><![CDATA[Ultracold gases provide unprecedented possibilities to study strongly correlated systems and address challenges indifferent fields of physics. The advantages they provide aretunability of interactions, possibility to control and exploredimensionality effects, disorder and quantum statistics. Theyallow the experimental realisation and study of both traditionalmodels from condensed matter physics and novel systems suchas spin-orbit coupled (SOC) bosons. Especially interesting are their universal properties, which enable establishment of connections betweenphenomena at different energy and length scales. The resonant regimeof zero-scattering length provides a universal strongly interacting unitary limit, where accurate theoretical predictions beyond mean field are necessary.  Quantum Monte Carlo (QMC) methods are able to accurately solve many-bodySchrodinger equation of atoms, molecules, liquids, solidsand different model systems. In the project we&#39;ll further developthe methods and apply them to problems in the field of coldBose and Fermi atoms, with the goal to characterize their universal properties. First, we&#39;ll study few-body systems,focusing on realistic molecular quantum halo states, such ashelium-alkali clusters. The goal is to establish whether universal scaling relations between energy and size, already established for trimers, can be established for clusters with more particles. This would provide benchmarkfor halo states in nuclear physics. Next, the effect of disorder and dimensionality on universal properties of trapped Bose-Bose and Bose-Fermi systems will be studied.Especially interesting is the superfluid-insulator transition and localization ofsuperfluidity and Bose-Einstein condensation. Finally, QMCmethods will be further developed so that spin degree offreedom is explicitly accounted for, which will allow study ofuniversality and novel phases of SOC gases.                                                                      ]]></summary_en></project><project>
<id>3688</id><title_hr><![CDATA[Optimizacija parametarski ovisnih mehaničkih sustava]]></title_hr><title_en><![CDATA[]]></title_en><user_id>935</user_id><user_firstLast_name>Ninoslav Truhar</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2015-10</proposal_call><code>DOK-2015-10-2914</code><acronim><![CDATA[OptPDMechSys]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Matematika, </scie_field_hr><scie_field_en>Mathematics, </scie_field_en><institution_hr><![CDATA[Sveučilište Josipa Jurja Strossmayera u Osijeku, Fakultet primijenjene matematike i informatike]]></institution_hr><institution_en><![CDATA[Josip Juraj Strossmayer University of Osijek, School of Applied Mathematics and Informatics]]></institution_en><team_members_id>22601</team_members_id><team_members_names><![CDATA[ Doktorand: Matea Puvača ]]></team_members_names><keywords_hr><![CDATA[veliki parametarski ovisni mehanički sustavi, nelinearni svojstveni problemi, optimizacija prigušenja, optimalno upravljanje, matrične jednadžbe]]></keywords_hr><keywords_en><![CDATA[ large-scaled parameter dependent mechanical systems,  nonlinear eigenvalue problem, damping optimization, optimal control, matrix equations]]></keywords_en><summary_hr><![CDATA[Ovaj je projekt posvećen proučavanju mehaničkih sustava drugog reda opisnih sustavom običnih diferencijalnih jednadžbi čije su matrice velikih dimenzija, ovisne o jednom ili više realnih parametara. Glavnina istraživanja bit će usmjerena na: optimizaciju aktivnog i pasivnog prigušenja, optimalno upravljanje parametarski ovisnim mehaničkim sustavima sa i bez vanjske sile; opisivanje svojstava svojstvenih vrijednosti i svojstvenih vektora parametarski ovisnog pripadnog kvadratnog odnosno nelinearnog problema.Za problem optimizacije aktivnog i pasivnog prigušenja mehaničkih sustava sa i bez vanjske sile, razvit ćemo opći teorijski okvir, i konstruirati adekvatne numeričke algoritme. Ta će teorijska razmatranja biti vezana za optimizaciju raznih parametara prigušenja vezanih uz nekoliko različitih optimizacijskih kriterija. Nadalje, u okviru navedenih problema rješavat ćemo mnoge numerički zahtjevne probleme: problem mješovite cjelobrojne nelinearne optimizacije, efikasno rješavanje velikih matričnih jednadžbi (Lyapunov, Sylvester, Riccati), poboljšanje optimizacijskih algoritama redukcijom modela. Takodjer ćemo razmatrati kako teorijski tako i numerički aspekt problema optimizacije semi-aktivnog prigušenja te optimalnog upravljanja s aspekta različitih kriterija.U okviru problema opisivanja ponašanja svojstvenih vrijednosti i svojstvenih vektora parametarski ovisnog kvadratnog problema, razvit ćemo perturbacijsku teoriju za pripadni kvadratni problem, pri čemu ćemo posebno proučavati slučaj kad je pripadni linearizirani par  dijagonalizabilan, a posebno kada je par definitan. Za oba slučaja razvit ćemo pripadne perturbacijske teorije apsolutnog i relativnog tipa.Navedeni problemi su povezani tako da će nam uvid u ponašanje svojsvenih vrijednosti i pripadnih vektora omogućiti bolje razumjevanje djelovanja prigušenja ili drugih dijelova mehaničkih sustava i obratno. ]]></summary_hr><summary_en><![CDATA[This project is devoted to the second order mechanical systems described by a system of differential equations, whose coefficient matrices are large-scaled and dependent on one or more real parameters.The majority of the research within this project will be focused on: optimization of active and passive damping and optimal control of parameter dependent mechanical systems with and without external force; describing the properties of eigenvalues and eigenvectors of the corresponding parameter-dependent quadratic or nonlinear problem.Within the problem of active and passive damping optimization and optimal control of parameter dependent mechanical systems with and without external force, we will develop a general theoretical framework. These theoretical considerations will be related to the optimization of various damping parameters with respect to a several different optimization criteria. Furthermore, within the stated objectives we will solve many numerical demanding problems: mixed-integer nonlinear optimization problem, efficiently solving of large matrix equations (Lyapunov, Sylvester, Riccati), improving the optimization algorithms by dimension reduction. We will also consider theoretical and numerical aspects of optimization of semi-active damping problem and optimal control based on various criteria.Within the problem of describing the behavior of eigenvalues and eigenvectors of the parameter-dependent nonlinear eigenvalue problems, we will develop perturbation theory for the corresponding quadratic problem separately for cases when the corresponding linearized  pair is diagonalizable or definite. For both cases we will develop perturbation theory of absolute and relative type for the eigenvalues and associated eigenvectors i.e. subspaces.The all mentioned problems are closely related, thus the insight into the behavior of eigenvalues and corresponding eigenvectors will allow better understanding of the behavior of mechanical systems and vice versa.]]></summary_en></project><project>
<id>3690</id><title_hr><![CDATA[Uspostava dugoročnog znanstvenog monitoringa prirodnih šumskih ekosustava u Hrvatskoj]]></title_hr><title_en><![CDATA[]]></title_en><user_id>3754</user_id><user_firstLast_name>Stjepan Mikac</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2015-10</proposal_call><code>DOK-2015-10-2593</code><acronim><![CDATA[CroFEM]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Šumarstvo, </scie_field_hr><scie_field_en>Forestry, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet šumarstva i drvne tehnologije]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Forestry and Wood Technology]]></institution_en><team_members_id>22826</team_members_id><team_members_names><![CDATA[ Doktorand: Domagoj  Trlin ]]></team_members_names><keywords_hr><![CDATA[ekstenzivni monitoring, intenzivni monitoring, prašume, dinamike prašuma, dugoročna promjene]]></keywords_hr><keywords_en><![CDATA[extensive monitoring, intensive, old-growth forest, forest dynamic, long-term changes]]></keywords_en><summary_hr><![CDATA[Hrvatska, u usporedbi s većinom Srednjoeuropskih zemalja, ima razmjerno prirodne šumske sa brojnim visoko vrijednim lokalitetima koji posjeduju karakter izvornih prašuma. Ideja o sustavnom multidisciplinarnom ekološkom monitoringu u Hrvatskoj pojavila se 1965. godine, no nije uspješno realizirana. Na osnovi te ideje, te potaknuto povećanjem sveukupnog interesa za praćenje promjena i dinamike prirodnih ekosustava, početkom 80-tih godina osnovane su trajne plohe po načelima UNESCO-vog programa MAB (Man and the Biosphere Programme). Nadahnuti potrebom za boljim razumijevanjem prirodne dinamike šumskih ekosustava i dugoročnim praćenjem promjena predlažemo ovaj projekt sa ciljem uspostave dugoročnog znanstvenog monitoringa, uz revitalizaciju postojećih i osnivanje novih ploha, čime će se stvoriti mreža terenskih laboratorija na kojima će sadašnji i budući znanstvenici nadograđivati svoje znanstvene kapacitete. Projektom se žele objediniti znanja i uspostaviti interdisciplinarna dugoročna istraživanja s jednim zajedničkim ciljem – razumijevanjei praćenje dinamike šumskih ekosustava. Projekt je zamišljen na dvije razine intenziteta monitoringa: 1) ekstenzivni monitoring-EM (I) i 2) intenzivni monitoring-IM (II). Ekstenzivni monitoring rezultirao bi sa 50-60 pokusnih objekata diljem Hrvatske dok bi se intenzivnim monitoringom obuhvatilo 5 najreprezentativnijih prašumskih objekata. IM treba poslužiti kao reprezentativni objekt istraživanja za sve plohe ekstenzivnoga monitoringa, dok EM omogućava procjenu u kojoj se mjeri rezultat intenzivnog monitoringa slučaja mogu generalizirati za jednaki stanišni tip, geološku podlogu, vegetacijska obilježja i slično sa relativno brzom i jeftinom izmjerom indikatora, koji pokazuju stanje ekosustava.]]></summary_hr><summary_en><![CDATA[Croatia, in comparison with most Central European countries, has a valuable forest areas with characteristics of a old-growth forest. The idea of systematic multidisciplinary, environmental monitoring in Croatia appeared in 1965. Based on these ideas, and driven by the growing interest in monitoring changes and dynamics of natural ecosystems, in early 80s the long-term, permanent monitoring plots  were established according to the principles of the UNESCO MAB program. Unfortunately, after the initial establishment, these plots were not systematically monitored. Inspired by the need for better understanding of the natural dynamics of forest ecosystems and the long-term monitoring we propose this project with the aim of establishing a long-term scientific monitoring. It  includes revitalization of existing and establishment of new monitoring plots which will,  in the end, represent a network of field laboratories where current and future researchers would build their research capacities. The project aims to consolidate knowledge and establish a long-term interdisciplinary research with one common goal – understanding and  monitoring the dynamics of forest ecosystems. The project is designed on two levels of intensity: 1) extensive monitoring-EM (I) and 2) intensive monitoring-IM (II). EM would result in the 50-60 plots across the Croatia while five of the most representative old-growth forest sites  will be the object of IM. IM should serve as a representative object of research for all plots of an EM, while EM enables the estimation of the  extent to which the results of the IM case study can be generalized for the habitat type, the geological substrate, vegetation characteristics and the like. This  by using relatively quick and inexpensive survey indicators, which show the status of ecosystem. ]]></summary_en></project><project>
<id>3691</id><title_hr><![CDATA[Kronične upalne bolesti crijeva u djece: incidencija, tijek bolesti te uloga prehrane i crijevne mikroflore u etiopatogenezi]]></title_hr><title_en><![CDATA[]]></title_en><user_id>2694</user_id><user_firstLast_name>Iva Hojsak</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2015-10</proposal_call><code>DOK-2015-10-9581</code><acronim><![CDATA[PED-IBD]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Kliničke medicinske znanosti, </scie_field_hr><scie_field_en>Clinical sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb School of Medicine]]></institution_en><team_members_id>21390</team_members_id><team_members_names><![CDATA[ Doktorand: Sara Sila ]]></team_members_names><keywords_hr><![CDATA[upalne bolesti crijeva, djeca, crijevna flora, enteralna prehrana, incidencija, registar]]></keywords_hr><keywords_en><![CDATA[inflammatory bowel disease, children, enteral nutrition, incidence, registry]]></keywords_en><summary_hr><![CDATA[Etiologija i patogeneza kroničnih upalnih bolesti crijeva (IBD - inflammatory bowel disease), unatoč visokoj prevalenciji, nisu razjašnjene. Predloženi mehanizam uključuje interakciju neodgovarajućeg (aberantnog) imunološkog odgovora na crijevnu mikrofloru / crijevni sadržaj, u genetski predisponiranih osoba. Cilj je ovog istraživačkog projekta pridonijeti rasvjetljavanju navedene patogeneze.Ciljevi. 1. Prehrana. Bolesnici s IBD-om vrlo često izbjegavaju određene namirnice u prehrani, pridajući im – po njihovu bolest – neželjena svojstva. Međutim, učinak takvih samonametnutih dijeta nije do sada istražen i za takve dijetetske postupke zasad nema znanstveno utemeljnog opravdanja. Od posebne je to važnosti za djecu u koje ozbiljnije dijetetske restrikcije mogu imati dugoročne posljedice na rast i razvitak. Stoga je prvi cilj ovog projekta utvrditi učestalost samoiniciranih dijeta u djece s IBD-om i procijeniti njihov učinak na: a) nutritivni status koristeći strogo definirane parametre, b) tijek bolesti. U istraživanje će se uključiti novodijagnosticirani bolesnici s IBD-om te zdrave kontrole.2. Crijevna mikroflora. Znanstveno je potvrđena terapijska učinkovitost isključive enteralne prehrane (EEN - exclusive enteral nutrition) na aktivnu formu Crohnove bolesti (CD) u djece, koja se, dijelom, pripisuje utjecaju na crijevnu mikrofloru. Međutim, dokaza o njihovoj povezanosti zasad nema. Stoga je drugi cilj ovog istraživanja utvrditi razliku u crijevnoj mikroflori u trenutku postavljanja dijagnoze i nakon indukcije remisije sa EEN. Crijevna mikroflora bolesnika usporedit će se s crijevnom mikroflorom zdravog brata ili sestre oboljelog djeteta i to neposredno prije, i dva dana nakon početka EEN. Nadalje, u djece s CD crijevna će se mikroflora odrediti i nakon završetka EEN te svakih dva mjeseca tijekom cijele prve godine praćenja. 3. PED-IBD registar. Do sada nije utvrđena incidencija, tijek i ishod bolesti („natural history“) u djece oboljele od IBD-a u Republici Hrvatskoj. Slijedom navedenoga, treći je cilj našeg projekta utemeljiti nacionalni registar djece s IBD-om s on-line bazom podataka koja će sadržavati sve važne kliničke i dijagnostičke parametre u sve djece s novodijagnosticiranom bolesti u Hrvatskoj. Podaci o bolesniku unositi će se kod dijagnoze i nakon godine dana praćenja. Za određivanje rizičnih čimbenika za nastanak relapsa koristit će se multivarijatna analiza koja će uključiti kliničke i terapijske parametre. ]]></summary_hr><summary_en><![CDATA[The etiology and pathogenesis of inflammatory bowel disease (IBD) have not been fully elucidated. 1. Diet. Patients with IBD, despite the absence of scientific evidence, often avoid certain types of food; however the effect of those self-imposed diets has not been determined. This is especially important in children whereby insufficient diet could have long-term consequences on growth and development. Therefore, the first objective of our study is to determine the frequency of self-induced diets in children with IBD and their impact on: a) nutritional status by using clearly defined parameters and b) course of the disease. The study will include newly diagnosed patients with IBD and healthy controls. 2. Intestinal microflora. It has been hypothesized that the excellent therapeutic effect of exclusive enteral nutrition (EEN) on pediatric active Crohn&#39;s disease (CD) could be explained by the effect on intestinal microflora. However, well performed studies are lacking. Therefore, the second objective of our study is to determine the difference in gut microflora at diagnosis and after remission induction achieved with EEN. Patients’ intestinal microflora will be compared with the microflora of healthy siblings before and two days after both groups receive EEN. Furthermore, in children with CD the intestinal microflora will be determined after 6 weeks of EEN and during the first year of follow up.  3. PED-IBD Registry. The incidence and natural history of pediatric IBD in Croatia has not been determined yet. The third goal of our project is to establish a national registry of children with IBD by providing an on-line database that will contain relevant clinical and diagnostic factors on all newly diagnosed pediatric IBD patients. To achieve this goal data will be entered at diagnosis and after one year of follow up. Multivariate analysis, which will include clinical and therapeutic parameters, will be used to determine risk factors for early disease relapse.]]></summary_en></project><project>
<id>3692</id><title_hr><![CDATA[Prirodno stanište klinički značajnih Acinetobacter baumannii]]></title_hr><title_en><![CDATA[]]></title_en><user_id>419</user_id><user_firstLast_name>Jasna Hrenović</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2015-10</proposal_call><code>DOK-2015-10-3123</code><acronim><![CDATA[NATURACI]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Biologija, </scie_field_hr><scie_field_en>Biology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>22631</team_members_id><team_members_names><![CDATA[ Doktorand: Svjetlana Dekić ]]></team_members_names><keywords_hr><![CDATA[Acinetobacter baumannii, Bakterije, Ekologija, Otpadna voda, Remedijacija, Tlo, Zeoliti]]></keywords_hr><keywords_en><![CDATA[Acinetobacter baumannii, Bacteria, Ecology, Remediation, Soli, Wastewater, Zeolites]]></keywords_en><summary_hr><![CDATA[Bakterija Acinetobacter baumannii je oportunistički patogen odgovoran za bolničke infekcije u imunokompromitiranih bolesnika, čija pojavnost dramatično raste tijekom zadnjeg desetljeća u Hrvatskoj i svijetu. Infekcije bakterijom A. baumannii se teško liječe zbog njihovih brojnih urođenih i stečenih mehanizama odgovornih za višestruku antibiotsku rezistenciju (multidrug-resistance; MDR), sposobnosti stvaranja biofilma, te dugotrajnog preživljavanja u bolnicama. Smatra se da su epidemije infekcija bakterijom A. baumannii uzrokovane isključivo kontaminacijom i prijenosom u bolničkom okruženju. MDR A. baumannii su nađene u bolničkim otpadnim vodama, ali ovakvi podaci nedostaju u Hrvatskoj. Do danas nije definirana pojavnost klinički važnih Acinetobacter spp. u prirodi niti njihov potencijal da prelaze u i/ili iz bolničkog okruženja. Potrebno je definirati prirodno stanište klinički važnih MDR A. baumannii. Postoji potreba za širim praćenjem te epidemiološkim studijama istraživanja utjecaja ljudskog otpada na rasprostranjivanje MDR A. baumannii. Cilj predloženog projekta je izolirati vijabilne MDR A. baumannii iz okolišnih uzoraka otpadne vode i tla. Okolišni izolati bit će genotipizirani te će biti određena njihova filogenetska srodnost s ljudskim izolatima kao i geni odgovorni za njihovu antibiotsku rezistenciju. Bit će određen i utjecaj ekoloških čimbenika na preživljavanje okolišnih izolata A. baumannii. Nadalje, istražit će se međudjelovanje okolišnih izolata A. baumannii i zeolita kao okolišno prihvatljivih dezinficijensa. Bit će razvijene metode i alternativni dezinficijensi na bazi prirodnih materijala za remedijaciju otpadnih voda i tla koja sadrže A. baumannii. Rezultati predloženog projekta će definirati prirodno stanište A. baumannii, te predložiti načine za smanjenje njihovog broja u zagađenom okolišu.]]></summary_hr><summary_en><![CDATA[Acinetobacter baumannii is an opportunistic pathogen responsible for nosocomial infections in immunocompromised patients, which emergence in hospital acquired infections increase dramatically over the last decade, both in Croatia and worldwide. Infections with A. baumannii are difficult to treat due to its ability to express multiple intrinsic and acquired mechanisms responsible for multidrug-resistance (MDR) to antibiotics, biofilm formation, and long-term persistence in hospitals. Outbreaks of A. baumannii infections are considered to be caused exclusively by contamination and transmission in hospital environment. MDR A. baumannii were detected in hospital wastewater, but such data are lacking in Croatia. The prevalence of clinically important Acinetobacter spp. in nature and their potential to migrate into and/or out of the hospital environments are undefined to date. The natural habitats of clinically important MDR A. baumannii remain to be defined. Larger screening and epidemiological studies should be performed to investigate the impact of human waste on the spread of MDR A. baumannii. The objective of the proposed project is to isolate viable MDR A. baumannii from the environmental samples of wastewater and soils. The environmental isolates will be genotyped and their phylogenetic relation to human isolates will be determined, as well as the profiles and genes responsible for their antibiotic resistance. The influence of ecological factors on the survival of environmental isolates of A. baumannii will be investigated. Interaction of environmental isolates of A. baumannii and zeolites as environmental friendly disinfectants will be studied. Methods and alternative disinfectants based on natural materials for the remediation of wastewater and soils containing A. baumannii will be developed. The findings of the proposed project will define the natural habitat of A. baumannii, and propose ways to reduce their numbers in contaminated environment.]]></summary_en></project><project>
<id>3693</id><title_hr><![CDATA[Sinteza i ciljana primjena metalnih nanočestica]]></title_hr><title_en><![CDATA[]]></title_en><user_id>158</user_id><user_firstLast_name>Iva Rezić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2015-10</proposal_call><code>DOK-2015-10-8492</code><acronim><![CDATA[STARS]]></acronim><duration>15.12.2016 - 06.12.2022</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Tekstilna tehnologija, </scie_field_hr><scie_field_en>Textile technology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Tekstilno-tehnološki fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Textile Technology]]></institution_en><team_members_id>22624</team_members_id><team_members_names><![CDATA[ Doktorand: Lela Pintarić ]]></team_members_names><keywords_hr><![CDATA[nanočestice, enzimi, polimeri, sol-gel proces, GEMMA, PDMA, GF-AAS, LC-MS/MS]]></keywords_hr><keywords_en><![CDATA[nanoparticles, enzymes, polymers, sol-gel process, GEMMA, PDMA, GF-AAS, LC-MS/MS]]></keywords_en><summary_hr><![CDATA[Glavni cilj projekta uspostava je interdisciplinarne međunarodne istraživačke skupine koja će sintetizirati nove metalne nanočestice pomoću ekološki prihvatljivih enzimski kataliziranih reakcija, te ih zatim nanositi na razne polimerne materijale. Metalne nanočestice imaju odlična nova elektronička, optička, magnetska, medicinska, katalitička i mehanička svojstva zahvaljujući specifičnoj površini koja izrazito ovisi o njihovoj veličini, strukturi i obliku. Predviđa se kako će globalna potražnja za nanočesticama metala i metalnih oksida porasti sa 270 tona u 2012. godini na 1700 tona u 2020. godini. Mi ćemo izolirati i primijeniti pet različitih enzima kako bi sintetizirali metalne nanočestice, odredili kinetiku i mehanizme provedenih reakcija, te zatim karakterizirali produkte reakcije uporabom “beyond-state-of-the-art“ instrumentalnih metoda (GEMMA, PDMA, MALDI-TOF-MS/MS i drugih tehnika). Provedba ovog projekta pomoći će pri osnivanju međunarodne istraživačke grupe koja će obuhvatiti teme iz područja nanotehnologije,  znanosti o materijalima, analitike i bioanalitike, a također će povećati istraživački potencijal mladih istraživača nabavkom znanstvene opreme koja je nužna za provođenje istraživanja vezanog uz sintezu i ciljanu primjenu metalnih nanočestica. Nakon nanošenja pojedinih ciljanih nanočestica na polimere, planiramo razviti nove materijale s namjenskom primjenom u ambalaži prehrambenih proizvoda i geotekstilija. Stoga će ovaj projekt podržati razvoj hrvatske prehrambene i tekstilne industrije. Nadalje, projekt će potaknuti interdisciplinarno istraživanje te omogućiti transfer znanja među istraživačkim grupama u Republici Hrvatskoj, kao i pružiti mogućnost transfera znanja studentima poslijedoktorskih, doktorskih i diplomskih studija koji će biti uključeni u projekt. Valja napomenuti kako će ovaj projekt ojačati i suradnju sa znanstvenicima europskih sveučilišta, te time poduprijeti integraciju hrvatskih znanstvenika u europski istraživački okvir.]]></summary_hr><summary_en><![CDATA[The main objective of this project is to establish international interdisciplinary research group that will synthesize new metal nanoparticles by environmental friendly enzymatic reactions and apply them on different polymer materials. Metal nanoparticles have novel electronic, optical, magnetic, medical, catalytic and mechanical properties owing to their high surface to volume ratio and the quantum size effect, which depend greatly on their size, structure and shape. Therefore a conservative estimation of the world market predicts the global consumption of metal oxide nanoparticles to rise from 270 tons in 2012 to 1700 tons by 2020. We will isolate and use five different enzymes to synthesize metallic nanoparticles, reveal the kinetics and mechanism of reactions, and characterize the products by using “beyond-state-of-the-art” instrumental methods (such as GEMMA, PDMA and MALDI-TOF-MS/MS). Implementation of this project will help establishing new interdisciplinary research group targeting problems in the fields of nanotechnology, material science and bio/analytical chemistry, as well as enhance the independent research leadership of the principal investigator by installing the scientific infrastructure necessary for research on the synthesis and targeted application of metal nanoparticles. By deposition of targeted nanoparticles on polymers, we will create new materials foreseen as food packaging materials and geotextiles. This will support the development of the Croatia’s food and textile industries. Moreover, the project will initiate interdisciplinary research with the transfer of knowledge among research groups, as well as provide the opportunity to transfer knowledge to postdoctoral, doctoral and diploma students working on this project. In addition, this project will strengthen international collaborations with scientists from other European universities, and by this support the integration of the Croatian science within the European research framework. ]]></summary_en></project><project>
<id>3695</id><title_hr><![CDATA[Detekcija objekata više razreda za pametna vozila i sigurnije ceste]]></title_hr><title_en><![CDATA[]]></title_en><user_id>361</user_id><user_firstLast_name>Siniša Šegvić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2015-10</proposal_call><code>DOK-2015-10-6366</code><acronim><![CDATA[MULTICLOD]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Računarstvo, </scie_field_hr><scie_field_en>Computer sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id>22805</team_members_id><team_members_names><![CDATA[ Doktorand: Petra Bevandić ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[Computer vision, structure from motion, object detection, image categorization, multi-body structure from motion]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Throughout the last decades we witness persistent improvement in understanding ways to make machines see. Consequently, opportunities for computer vision applications are becoming more and more abundant. Understanding dynamic traffic scenes is especially interesting due to exciting applications in the fields of smart vehicles (driver assistance, autonomous cars) and intelligent transportation systems (road safety inspection, adaptive traffic control). Nevertheless, many of these applications are out of reach since the computers are still unable to match human perception. We believe that this gap would be reduced by improving our understanding of scalable detection of multiple object classes in dynamic scenes.The task of object detection is to localize objects of interest in input images. We address detection in the most general case where the objects of interest exhibit large appearance variation. In this case the problem is often referred to as multi-class object detection. Our proposal focuses on dynamic traffic scenes acquired by a calibrated stereo rig from the driver&#39;s perspective. We propose to develop detection approaches which would combine estimated camera motion and scene structure with learned appearance features, and to experimentally compare them with the state of the art. We shall employ advanced methodologies such as SfM, dense stereo, variational optimization, scene flow, spatio-temporal descriptors, latent SVM and Fisher vectors. These methodologies shall enable us to achieve improvements upon the state of the art in terms of scalability and detection performance. This will open way to exciting applications capable of reducing traffic accidents, improving efficiency and decreasing traffic congestion. Some of these applications shall be demonstrated by experiments on a real autonomous car. The proposed research would also contribute to a future unified theory of computer vision which would encompass detection, reconstruction and categorization.]]></summary_en></project><project>
<id>3696</id><title_hr><![CDATA[Novi metal-organski sustavi s oksalatnim i kinoidnim ligandima s podešenim svojstvima pogodnim za primjenu]]></title_hr><title_en><![CDATA[]]></title_en><user_id>12831</user_id><user_firstLast_name>Marijana Jurić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2015-10</proposal_call><code>DOK-2015-10-6941</code><acronim><![CDATA[NMOSBOQLWTPSFP]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, </scie_field_hr><scie_field_en>Chemistry, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>21308</team_members_id><team_members_names><![CDATA[ Doktorand: Lidija Kanižaj ]]></team_members_names><keywords_hr><![CDATA[funkcionalni materijali, kristalno inženjerstvo, kristalna struktura, magnetska svojstva, koordinacijski polimeri, miješani oksidi, oksalati, kinoni]]></keywords_hr><keywords_en><![CDATA[functional materials, crystal engineering, crystal structure, magnetic properties, coordination polymers, mixed metal oxides, oxalates, quinones]]></keywords_en><summary_hr><![CDATA[Cilj projekta je učinkovit i postupan dizajn novih i naprednih funkcionalnih materijala temeljenih na metal-organskim kompleksima. Kombinacijom metalnih centara s polidentatnim organskim ligandima dobivaju se strukturno raznolike rešetke različitih magnetskih električnih, termičkih, optičkih i drugih svojstava. U predloženom projektu, dva analogna premošćujuća liganda, oksalat i supstituirani 2,5-dihidroksikinonat (DHQ), koristit će se u pripravi koordinacijskih polimera različite dimenzionalnosti i topologije. Njihove interakcije s prijelaznim metalnim kationima obuhvaćaju različita magnetska svojstva, koje se mogu mijenjati izborom točno određenih strukturnih fragmenata. Oksalatni kompleksi će se istraživati ne samo kao mogući magnetski materijali s uređenjem pri određenoj temperaturi, nego kao i prekursori za pripravu tehnološki važnih miješanih metalnih oksida termičkom razgradnjom u jednom koraku. Ova metoda priprave oksida, u odnosu na standardne reakcije u čvrstom stanju, ima nekoliko prednosti: kraća termička obrada na nižoj temperaturi, nema ponavljanja postupaka mljevenja, a produkti su homogeniji. DHQ-kompleksi proučavat će se zbog njihovog potencijala za prijenos naboja, što bi moglo dovesti do materijala s reverzibilnim magnetskim prijelazom. Također, obećavajuća skupina liganada su stabilni semikinonski radikali, dobiveni iz različito supstituiranih DHQ-ova. Njihovi su kompleksi s prijelaznim metalima do sada malo poznati i nisu bili korišteni za izradu funkcionalnih materijala. Interdisciplinarnost projekta zahtjeva različite metode za karakterizaciju ovih naprednih materijala: difrakciju rendgenskih zraka na monokristalu i prahu, uključujući određivanje gustoće naboja, termičku analizu (TG / DTA), IR-, UV/Vis- i EPR-spektroskopiju, itd. Dobiveni će se rezultati koristiti za povezivanje njihovih struktura i svojstava.]]></summary_hr><summary_en><![CDATA[The project targets at efficient and progressive design of novel and advanced functional materials based on metal-organic complexes. Combination of metal centres with polydentate organic ligands provide colossal, structurally-diverse, platforms possessing a variety of magnetic, electrical, thermal, optical and other properties. In the proposed project, two analogue bridging ligands, oxalate and substituted 2,5-dihydroxyquinonate (DHQ), will be used in the preparation of the coordination polymers of different dimensionality and topology. Their interactions with transition metal cations involve a variety of magnetic phenomena, which can be tuned by highly sensitive selection of structural fragments. The oxalate-based complexes will be studied not only as potential magnetic materials ordering at a certain temperature, but also as the single-source precursors for the preparation of technologically important mixed-metal oxides through the thermal decomposition process. This method of preparing oxides, as compared to conventional solid-state reactions, has several advantages: shorter thermal treatment at lower temperature, without repeating grinding procedures, and the products are more homogeneous. The DHQ complexes will be studied due to their potential for charge transfer, which may lead to materials with reversible magnetic transition. Also, promising class of the ligands are stable semiquinone radicals derived from variously substituted DHQs. So far, their complexes with transition metals are little-known and have not been exploited for design of functional materials.The interdisciplinary nature of the project requires a variety of methods to characterise these advanced materials: single-crystal and powder X-ray diffractions including X-ray charge density studies, thermal analyses (TG/DTA), IR, UV/Vis and EPR spectroscopies, etc. The results obtained will be used to correlate their structure and properties.]]></summary_en></project><project>
<id>3697</id><title_hr><![CDATA[Nanokompoziti cinkovog oksida i titanijevog dioksida za fotonaponsku primjenu]]></title_hr><title_en><![CDATA[]]></title_en><user_id>3922</user_id><user_firstLast_name>Andreja Gajović</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2015-10</proposal_call><code>DOK-2015-10-6633</code><acronim><![CDATA[ZOTONanoPhotovolt]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, </scie_field_hr><scie_field_en>Physics, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>22641</team_members_id><team_members_names><![CDATA[ Doktorand: Ivana Panžić ]]></team_members_names><keywords_hr><![CDATA[cinkov oksid, titanijev dioksid, nanokompoziti, fotonaponski uređaji, kemijske metode, magnetronsko rasprašivanje,  pulsna laserska depozicija]]></keywords_hr><keywords_en><![CDATA[zinc oxide, titanium diokside, nanocomposites, photovoltaic solar cells, chemical methods, magnetrons sputtering and pulsed laser deposition]]></keywords_en><summary_hr><![CDATA[Istraživat će se mogućnosti modificiranja svojstava tankih filmova metalnih oksida, prvenstveno ZnO  i TiO2, podešavanjem njihove nano-strukture i aktiviranjem njihove površine. Svojstva će se optimirati primarno za upotrebu u fotonaponskim uređajima no rezultati će biti primjenjivi i za druge opto-električne uređaje, razne vrste senzora, katalizatora itd. Pri tom će se određivati korelacija (nano)strukturnih osobina sa optičkim, vibracijskim i električnim osobinama s jedne strane te ovisnost strukture o parametrima formiranja sa druge. Ovo će omogućiti provjeru teoretskih predviđanja vezanih za defekte i nisko-dimenzionalne strukture i modeliranje rasta tankih filmova. Nastojat će se realizirati nano-strukture koje su izdužene u smjeru okomitom na površinu,  sastoje se od jedne vrste oksida a dekorirane su drugom vrstom oksida. Od njih se očekuje značajno povećanje efikasnosti fotonaponskih ćelija. Tehnike priprave će biti: (i) kemijske metode, (ii) vakuumske depozicije pomoću magnetronskog rasprašivanja i pulsne laserske depozicije (PLD). Kemijske metode (uključujući sol-gel tehnike i hidrotermalnu sintezu) ostavljaju velike mogućnosti u formiranju raznih nano-struktura (npr. nano-kristali, nano-žice, nano-plohe, nano-cjevčice) i olakšavaju veću fleksibilnost pri optimizaciji priprave te bolju statistiku u određivanju povezanosti  nano-strukture sa svojstvima. S druge strane, fotonaponske solarne ćelije podrazumijevaju formiranje slojeva na velikim površinama pa razne tehnike formiranja kao što su magnetronska depozicija i PLD imaju evidentnu prednost. Također, obrada površine plazmom je prirodno povezana sa magnetronskom depozicijom i PLD. Zbog toga će se posebna pažnja posvetiti ovim dvjema tehnikama. Optimalne strukturna svojstva, koji će se eksperimentalno potvrditi kombinacijom kemijskih metoda, će se nastojati postići magnetronskom depozicijom i PLD.Projekt će dijelom bit posvećen edukaciji doktorskih i postdoktorskiih studenta. ]]></summary_hr><summary_en><![CDATA[The possibility of modification the properties of thin film metal oxides , primary ZnO and TiO2,  by adjusting nano-structure and by activation of surfaces will be explored. The properties will be primary adjusted for use in photovoltaic solar cells while results will be applicable for other opto-electronic devices, sensors, catalysts etc.Project activities assume study of correlation between details of (nano)structural properties with optical, vibrational and electrical from one side and correlation between structure and parameters of deposition from other side. This will enable test of theoretical predictions related to defects and low dimensional structures and models of thin film growth as well. The main challenge is nano-structures elongated in the direction perpendicular to the surface, based on one type of oxide while decorated with other type of oxide. By using these structures significant increase the efficiency of photovoltaic cells is expected.Two basic preparation techniques will be used: (i) chemical methods and (ii) vacuum deposition by magnetrons sputtering and pulsed laser deposition (PLD). The chemical methods (including sol-gel technique and hydrothermal syntheses) enable relatively simple formation of various nano-structures (e. g. nano-crystals, nano-wires, nano-sheets, nano-tubes) providing larger flexibility for optimization of the preparation, and better statistics for understanding the correlation between nano-structure and properties. On the other hand, photovoltaic solar cells assume deposition of the films on large areas and for this purpose magnetron sputtering and PLD seem more suitable. Furthermore, the surface modification by plasma treatment looks appealing in combination with vacuum deposition techniques or PLD. That is why the optimal structural properties found by chemical methods will be goal to be obtained by magnetron sputtering or PLD techniques. Project will be partially devoted to education of the PhD and Postdoc. students.]]></summary_en></project><project>
<id>3699</id><title_hr><![CDATA[Održivi razvoj inovacije u hrani - valorizacija otpada masline]]></title_hr><title_en><![CDATA[]]></title_en><user_id>3927</user_id><user_firstLast_name>Dubravka Vitali Čepo</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2015-10</proposal_call><code>DOK-2015-10-5489</code><acronim><![CDATA[NutriOliWa]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Farmacija, </scie_field_hr><scie_field_en>Pharmaceutical sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Farmaceutsko-biokemijski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Pharmacy and Biochemistry]]></institution_en><team_members_id>21381</team_members_id><team_members_names><![CDATA[ Doktorand: Sanja Jurmanović ]]></team_members_names><keywords_hr><![CDATA[otpad masline, održivi razvoj,  dodatak prehrani, antioksidans, bioraspoloživost, polifenoli]]></keywords_hr><keywords_en><![CDATA[olive waste, sustainable development, antioxidant, food supplement, bioavailability, polyphenols]]></keywords_en><summary_hr><![CDATA[Direktno odlaganje u okoliš otpada koji zaostaje nakon proizvodnje maslinovog ulja, veliki je ekološki problem. Ponovno iskorištavanje otpada masline u samom je začetku te njen potencijal, kao polazne sirovine, još uvijek nije ni izbliza iskorišten. Polifenoli u otpadu masline prepoznati su kao visokovrijedni spojevi no usprkos velikom broju bioloških učinaka, njihova primjena u područjima funkcionalne hrane i dodataka prehrani kao i daljnja istraživanja njihove bološke učinkovitosti vrlo su ograničena. Glavnih razlozi tome su nedostatak prihvatljivih metoda izolacije; te loša kvaliteta i karakterizacija postojećih ekstrakta što dodatno ograničava njihovu širu primjenu i istraživanje. Stoga su glavni ciljevi projekta:1. razviti učinkovit i ekološki prihvatljiv postupak ekstrakcije polifenola iz komine masline korištenjem suvremenih, nekonvencionalnih tehnika kao što su primjena ultrazvuka ili mikrovalova, zasebno ili u kombinaciji s procesom mikroenkapsulacije. 2. razviti inovativne i održive protokole formulacije visokokvalitetnog krutog ekstrakta korištenjem inovativnih tehnoloških i metodoloških pristupa 3. provesti funkcionalnu karakterizaciju dobivenih ekstrakata korištenjem suvremenih in vitro metodoloških pristupa (antioksidacijska aktivnost u modelima hrane, bioraspoloživost, apsorpcija i metabolizam polifenola iz čvrstih ekstrakta, biološka učinkovitost) Osim što će pružiti nove znanstvene spoznaje te mogu poslužiti kao izvrstan temelj za daljnja znanstvena istraživanja specifičnih bioloških učinaka, rezultati ovog projekta nalaze i vrlo konkretnu primjenu u okvirima prehrambene- i farmaceutske industrije. U širem smislu, rezultati ovog projekta pružit će bitan doprinos kvaliteti upravljanja otpadom iz agro-prehrambenog sektora što će rezultirati značajnom ekološkom i ekonomskom korišću u budućnosti.  ]]></summary_hr><summary_en><![CDATA[The olive oil industry gives place to vast amounts of residues and when discarded untreated directly to the environment, they present a major ecological issue. Although some of these residues are beginning  to be managed to a certain extent, higher benefits should be obtained from these materials. Polyphenols abundant in olive waste have been recognized as compounds of high added value but due to the lack of efficient methods of isolation; significant variations in quality of available extracts and lack of their chemical characterization, the possibilities of further investigation of their health related properties  and utilization in the segment of functional foods or dietary supplements is very limited. The major goals of this projects are:1. to develop sustainable procedure for the extraction of polyphenols from olive waste by using unconventional extraction techniques such as ultratrasound- and microwave assisted extraction, alone or in combination with microencapsulation. That should provide significant advantages over the traditional extractions methods 2. to develop efficient drying procedure for obtaining crude olive pomace extracts (COPE) using contemporary methodological approaches with satisfactory physico-chemical properties, organoleptic characteristics and increased shelf-life. 3. to provide functional characterization of COPE using contemporary methodological approaches (bioavailability and absorption of active compounds from COPE, antioxidant activity in food model systems and biological activity)In addition to providing novel scientific knowledge and serve as the excellent starting point for further scientific investigations of particular biological activities, the results of this project have great potential to be further used by food- and pharmaceutical industry. Also, in broader sense, obtained results will contribute to the meaningful management of olive mill waste resulting with both economical and ecological benefit in the future.]]></summary_en></project><project>
<id>3701</id><title_hr><![CDATA[Minimalni umjetni enzimi: Proširenje primjene &#39;&#39;posredne indukcije&#39;&#39; na nove supstrate i nove asimetrične reakcije]]></title_hr><title_en><![CDATA[]]></title_en><user_id>355</user_id><user_firstLast_name>Srećko Kirin</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2015-10</proposal_call><code>DOK-2015-10-2072</code><acronim><![CDATA[MArtEn]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, </scie_field_hr><scie_field_en>Chemistry, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>21301</team_members_id><team_members_names><![CDATA[ Doktorand: Saša Opačak ]]></team_members_names><keywords_hr><![CDATA[aminokiseline, asimetrična kataliza, bioanorganska kemija, koordinacijska kemija, supramolekulska kemija]]></keywords_hr><keywords_en><![CDATA[Amino Acids, Asymmetric Catalysis, Bioinorganic Chemistry, Coordination Chemistry, Supramolecular Chemistry]]></keywords_en><summary_hr><![CDATA[Svrha ovog projekta je razvoj kiralnih katalizatora prijelaznih metala s posebnim naglaskom na inspiraciju iz prirode. Predložena je struktura beta-okreta kao ključno obilježje kiralnih katalizatora koji oponašaju umjetne enzime s minimalnom, ali fukcionalnom kiralnom vanjskom koordinacijskom sferom. Ovi minimalni umjetni enzimi mogli bi naći primjenu u asimetričnoj sintezi lijekova ili međuprodukata lijekova proizvedenih u farmaceutskoj industriji.U asimetričnoj katalizi opće je prihvaćeno da kiralna informacija mora biti prisutna što bliže koordinacijskoj sferi katalitičkog metala. Mi propitujemo ovo važno načelo i koristimo katalitički metalni centar koji je samo prokiralan. Kiralna informacija se prenosi &#39;&#39;posrednom indukcijom&#39;&#39; putem vodikovih veza udaljenih aminokiselina koje predstavljaju vanjsku koordinacijsku sferu. Preliminarni rezultati snažno podržavaju izvodljivost projekta, jer pokazuju da jednostavni biokonjugati monodentatnih trifenilfosfanskih liganada mogu tvoriti supramolekulske L2M komplekse s Rh(I) koji selektivno kataliziraju modelnu reakciju asimetričnog hidrogeniranja sa značajnim utjecajem redosljeda udaljenih aminokiselina na selektivnost [Kirin and Kokan, RSC Adv. 2012, Eur. J. Org. Chem. 2013 i Organometallics 2014; e.v. do 84 %].U okviru ovog projekta, predloženo je značajno proširenje uključujući (i) uporebu novih biokonjugata liganada s fosfornim ili dušikovim donorskim atomom, (i) uporeba novih supstrata te (iii) upotreba drugih prijelaznih metala za različite asimetrične reakcije, kao što su Ru(II)-katalizirano hidrogeniranje, Pd(II)-katalizirana alkilacija i Ln(III)-katalizirana sililcijanacija.]]></summary_hr><summary_en><![CDATA[This project aims at the development of chiral transition metal catalysts with particular emphasis on inspiration taken from nature. A beta-turn structure is proposed as key feature of chiral catalysts that resemble artificial enzymes with a minimal but functional outer-coordination sphere. These minimal artificial enzymes could find applications in asymmetric synthesis of drugs or drug intermediates produced by pharmaceutical industry.In asymmetric catalysis it is well established that the chiral information should be incorporated as close as possible to the coordination sphere of the catalytic metal. We challenge this important principle and use a catalytic metal center that is only prochiral. The chirality is transmitted by &#39;&#39;backdoor induction&#39;&#39; via hydrogen bonding of distant pendant amino acids that represent the outer-coordination sphere. Preliminary results provide a proof of concept and strongly indicate that simple amino acid bioconjugates of monodentate triphenylphosphane ligands can form supramolecular L2M complexes with Rh(I) that selectively catalyze a model asymmetric hydrogenation reaction with major impact of the distant amino acid sequence on selectivity [Kirin and Kokan, RSC Adv. 2012, Eur. J. Org. Chem. 2013 and Organometallics 2014; ee’s up to 84 %].Within this project, a significant extension is proposed including (i) the use of new ligand bioconjugates with phosphorous or nitrogen donor atoms, (ii) the use of new substrates and (iii) the use of other transition metals for different asymmetric reactions, namely Ru(II)-catalyzed hydrogenation, Pd(II)-catalyzed alkylation and Ln(III) catalyzed silylcyanation.]]></summary_en></project><project>
<id>3702</id><title_hr><![CDATA[ HIBRIBRIDNE SILICIJSKE NANOSTRUKTURE ZA SENZORIKU]]></title_hr><title_en><![CDATA[]]></title_en><user_id>3688</user_id><user_firstLast_name>Mile Ivanda</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2015-10</proposal_call><code>DOK-2015-10-3271</code><acronim><![CDATA[NANOSENS]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, </scie_field_hr><scie_field_en>Physics, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>25427</team_members_id><team_members_names><![CDATA[ Doktorand: Daniil Zhivotkov ]]></team_members_names><keywords_hr><![CDATA[SILICIJ, NANOSTRUKTURE, SENZORI, HIBRIDNE KOMPONENTE, ORGANSKI POLUVODIČI]]></keywords_hr><keywords_en><![CDATA[SILICON, NANOSTRUCTURES, SENSORS, HYBRID COMPONENTS, ORGANIC SEMICONDUCTORS]]></keywords_en><summary_hr><![CDATA[Prijedlog projekta temelji se na našim prethodnim aktivnostima kojima smo naučili pripraviti kvalitetne uzorke nanostrukturiranog silicija. Razvili smo i ideje te stekli znanja i iskustvo za daljnje eksperimentalne tretmane uzoraka kako bi se razvila nova svojstava s ciljem veće konkurentnosti kod određenih primjena.  Projekt se bavi temeljnim fizikalnim i kemijskim svojstvima i primjeni hibridnih silicijevih nanostruktura pripravljanim elektrokemijskim jetkanjem i kemijskom depozicijom iz pare pod niskim tlakom (LPCVD). Projektni prijedlog sadrži četiri međusobno povezana istraživačka zadataka: silicijeve hibridne nanostrukture za plinske senzore;  vrlo osjetljivi detektori za infracrvenu svjetlost; površinski pojačana Ramanova spektroskopija (SERS) u prehrambenoj tehnologiji i sferni optički mikrorezonatori u molekulskoj detekciji. Predloženi zadaci projekta su međusobno povezani preko priprave hibridnih materijala na temelju jeftinog silicija kompatibilnog CMOS tehnologiji u svrhu razvoja navedenih primjena. Za realizaciju predloženih istraživačkih zadataka organiziran je istraživački tim od 14 istraživača (9 znanstvenika i 5 doktorandada) sa 2 znanstvena instituta, 2 fakulteta, 1 instituta u privatnom sektoru i 2 instituta iz inozemstva. Elektrokemijski procesi jetkanja će se koristiti za pripravu silicija s porama odgovarajućih veličina i volumena s mogućom kontrolom od nanometarske do mikrometarske veličine. Različite kemijske metode biti će primjenjene za funkcionalizaciju poroznih silicijevih struktura pri istraživanjima i razvoju detekcije plina, IR senzora i SERS spektroskopije. Nove silicijeve heterostrukture pripravljene LPCVD metodom na sfernim kvarcnim optičkim microrezonatorima istraživati će se obzirom na mogućnosti primjene u detekciji molekula. Strukturna, optička i elektronska svojstva predloženih funkcionalnih silicijskih nanostruktura istraživati će se sa gledišta temeljnih spoznaja kao i u svrhu razvoja specifičnih proizvoda visoke tehnologije potrebnih hrvatskoj industriji.]]></summary_hr><summary_en><![CDATA[The project proposal is based on our prior research activities where we learned how to prepare high quality nanostructured silicon. We have also developed ideas and gained knowledge and experience for further experimental treatments of our samples aimed on development of new properties competitive for specific applications. The project addresses fundamental physics and chemistry, properties and application of silicon hybrid nanostructures prepared by electrochemical anodisation and low pressure chemical vapour deposition (LPCVD). The project proposal consists of four interrelated research tasks: silicon/hybrid nanostructures for gas sensing; low light infrared detection; surface enhanced Raman spectroscopy (SERS) in food technology and spherical optical microresonators in low concentration molecular detection. The proposed tasks are mutually interconnected by the CMOS technology compatible materials production based on inexpensive silicon, and by the search for their specific advanced applications. For the achievement of the proposed research tasks we have organized a team of 14 researchers (9 scientists and 5 PhD students) from 2 scientific institutions, 2 faculties and 1 institution in the private sector and 2 renowned institutions from abroad. Electrochemical processes will be used for construction of tailored pore sizes and volumes in silicon that are controllable on the scale from nano- to micrometers. A number of suitable chemistries will be applied for the functionalization of porous Si surfaces for gas sensing, IR sensors and SERS spectroscopy. The novel silicon heterostructures deposited by the LPCVD method on silica spherical optical microresonators will be investigated for possible applications in molecular sensing. The structural, optical and electrical properties of such functional silicon nanostructures will be examined from the fundamental science point of view as well as for development of specific high-tech products needed by the Croatian industry. ]]></summary_en></project><project>
<id>3703</id><title_hr><![CDATA[Postupci strojnog učenja za dubinsku analizu složenih struktura podataka]]></title_hr><title_en><![CDATA[]]></title_en><user_id>3806</user_id><user_firstLast_name>Tomislav Šmuc</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2015-10</proposal_call><code>DOK-2015-10-2244</code><acronim><![CDATA[DescriptiveInduction]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Računarstvo, </scie_field_hr><scie_field_en>Computer sciences, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>22813</team_members_id><team_members_names><![CDATA[ Doktorand: Matej Mihelčić ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[machine learning, knowledge discovery, structured data, rule learning, FPGA]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[ Induction is a process of knowledge extraction from information contained in data. In our work we will concentrate on descriptive induction whose goal is to construct knowledge that enables human understanding of the data. Included are techniques for construction of user-interpretable models, segmentation of the corpus of examples, and detection of outliers. The methodology is relevant for the computer science fields known as intelligent data analysis, knowledge discovery from data, and data mining. At Rudjer Boskovic Institute we are developing machine learning algorithms for more than 15 years and we have successfully applied them in various domains including chemistry, biology, medicine, social sciences, economics, and manufacturing. With this project we want to extend the existing methodology and to implement novel techniques able to cope with data contained in complex structures. The main topic will be spatio-temporal structures but we will work also with networks of data, relational databases, and data contained in ontologies. Previous experience clearly demonstrates that complete transformation of information contained in structured data into a form that may enter the induction process is not a simple task. Our goal is to develop and implement systematic and general approaches for this conversion. The consequence will be explosion of generated data that must enter into the process of induction. Therefore, the second goal will be implementation of efficient algorithms for descriptive induction. The work includes development of novel algorithms for clustering and outlier detection in sets of unclassified examples and implementation of hardware for fast execution of rule learning algorithms. The third goal is application and evaluation of implemented algorithms in various real-life domains. The success of the complete project will be measured by the quality and usefulness of knowledge obtained in these applications.]]></summary_en></project><project>
<id>3705</id><title_hr><![CDATA[Organska zagađivala u okolišu - markeri i biomarkeri toksičnosti]]></title_hr><title_en><![CDATA[]]></title_en><user_id>5026</user_id><user_firstLast_name>Davor Želježić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2015-10</proposal_call><code>DOK-2015-10-6005</code><acronim><![CDATA[OPENTOX]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Javno zdravstvo i zdravstvena zaštita, </scie_field_hr><scie_field_en>Public health and health services, </scie_field_en><institution_hr><![CDATA[Institut za medicinska istraživanja i medicinu rada]]></institution_hr><institution_en><![CDATA[Institute for Medical Research and Occupational Health]]></institution_en><team_members_id>22614</team_members_id><team_members_names><![CDATA[ Doktorand: Vedran Mužinić Mužinić ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[pesticides, organochlorine pollutants, genotoxicity, endocrine disruption, oxidative stress, cytoskeleton, environmental distribution, risk assessment]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[The proposed project is based on Directive 2009/128/EC, the EU Thematic Strategy for Pesticides, and the Collegium Ramazzini Statement concerning control over pesticides and their impact on human health and the environment. The project will focus on studying two major pesticide classes with three subgroups per each: (A) insecticides (organophosphates, neonicotinoids, and pyrethroids), (B) herbicides (triazines, organophosphates, allelopathic), and persistent organochlorine pollutants under the Stockholm convention. Low concentrations corresponding to real-life exposures will be evaluated based on residential exposure levels, occupational exposure limits, acceptable daily intakes, and reference doses in appropriate cell lines and animal models. The malsegregation of chromosomes (X, Y, 9), integrity of gatekeeping genes (TP53, c-Myc), and protein structures (cytoskeleton components) will be studied within the transplacental genotoxic evaluation of selected pesticide groups. Among these, some are suspected to be endocrine disruptors. Potential effects on sex hormone levels will be assessed in neonatal rats and transfer via mother’s milk in pubertal rats. Oxidative stress will be estimated by measuring lipid peroxidation and activity of antioxidative enzymes in vitro and in vivo. We will study the processes affecting the distribution of pesticides in water/soil systems as well as the genotoxicity of their residues in soil and water. Results for low levels of pollutant exposure will serve to significantly extend the knowledge on their genotoxicity, cytotoxicity, sex endocrine disruption, mechanisms of oxidative stress, and distribution in the environment. Also, they will be used as a base for amending and adopting the Croatian National Action Plan for sustainable use of pesticides in accordance with demands postulated in Directive 2009/128/EC and the EU Thematic Strategy for Pesticides.]]></summary_en></project><project>
<id>3706</id><title_hr><![CDATA[Anisakis spp: genomska epidemiologija]]></title_hr><title_en><![CDATA[]]></title_en><user_id>132</user_id><user_firstLast_name>Ivona Mladineo</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2015-10</proposal_call><code>DOK-2015-10-9360</code><acronim><![CDATA[AnGEL]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Veterinarska medicina, </scie_field_hr><scie_field_en>Veterinary medicine, </scie_field_en><institution_hr><![CDATA[Institut za oceanografiju i ribarstvo]]></institution_hr><institution_en><![CDATA[Institute of Oceanography and Fisheries]]></institution_en><team_members_id>13683</team_members_id><team_members_names><![CDATA[ Doktorand: Jerko Hrabar ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[Anisakis spp., zoonosis, seroprevalence, patohistology, transcriptomic, risk analysis]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Global migration and trade of the foodstuff, climate change, novel trends in human eating habits characterised by an elevated demand for raw food, are today considered as major reasons why reports of food borne infections, especially zoonotic parasitosis, have increased in the last decade. Thus the prevention and protection against zoonotic parasites in fishery products designated for human consumption has recently become a priority. Consequently, health authorities and fishing industry have increasingly become aware of the significance of nematode genus Anisakis, which affects human health and the commercial value of fish products. Adriatic fish, marketed fresh, frozen, salted or marinated and exported to EC, are frequently rejected on the border because of Anisakis infection. Although considered one of the most significant emerging food-borne zoonosis, anisakiasis in many Mediterranean countries is still misdiagnosed or underestimated. AnGEL will deepen the knowledge on Anisakis with a multidisciplinary approach, studying the fish as paratenic, cetaceans as the final and men as accidental host. It will start by identifying anisakids species by molecular tools in picarel and damselfish, that are particular dish in culinary tradition of SE Adriatic islands where a significant level of anti-Anisakis IgE in local population was found. It will evaluate histopathological effect of the nematode in the digestive tract of the final host in order to evaluate Anisakis carcinogenic potential, as well as its transciptomic signature during migration through hosts. It will assess larval multixenobiotic resistance mechanisms helping to design more effective therapy, and measure anti-Anisakis seroprevalence in population employed in the fish processing industry by indirect ELISA. Lastly, AnGEL will encompass resulting data in a risk analysis frame, aiming to the design of measures for the safe alimentary seafood production and strengthening of risk communication to stakeholders.]]></summary_en></project><project>
<id>3707</id><title_hr><![CDATA[Razvoj evolucijskih postupaka za karakterizaciju ponašanja bioloških tkiva]]></title_hr><title_en><![CDATA[]]></title_en><user_id>11229</user_id><user_firstLast_name>Marina Franulović</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2015-10</proposal_call><code>DOK-2015-10-1303</code><acronim><![CDATA[BIOMAT]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Strojarstvo, </scie_field_hr><scie_field_en>Mechnical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Tehnički fakultet]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Engineering]]></institution_en><team_members_id>22633</team_members_id><team_members_names><![CDATA[ Doktorand: Stjepan Piličić ]]></team_members_names><keywords_hr><![CDATA[biološki materijali, karakterizacija materijala, materijalni model, materijalni parametri, genetski algoritam]]></keywords_hr><keywords_en><![CDATA[biological materials, material characterization, material model, material parameters, genetic algorithm]]></keywords_en><summary_hr><![CDATA[U inženjerstvu sve se veća pažnja posvećuje poboljšanju značajki konvencionalnih i razvoju inovativnih materijala. Iako je istraživanje materijala uvelike usmjereno na metale, polimere, staklo, keramiku, kompozite itd., sve veći interes posvećuje se biološkim sustavima i materijalima (školjke, kosti, paukova svila, mišići itsl.) zbog njihovih svojstava koje uvelike nadvisuju one konvencionalnih materijala. Ponašanje i modeliranje bioloških materijala je kompleksno, ali se kao i modeliranje konvencionalnih materijala bazira na poznavanju i eksperimentalnom određivanju njihovih karakteristika. Pored materijalnog modela za opisivanje ponašanja materijala, osnovni preduvjet za modeliranje je identifikacija materijalnih parametara. Prethodno je ustanovljeno da je za identifikaciju parametara bioloških materijala potrebnih za modeliranje njihovog ponašanja preporučljivo primijeniti evolucijske metode, a posebno genetski algoritam. U okviru projekta karakterizirat će se i modelirati ponašanje vratnih ligamenata ljudske kralježnice na osnovi podataka dobivenih eksperimentima. Odabran je hiperelastični materijalni model koji se može koristiti i za kompresibilne i nekompresibilne materijale. Kako bi se na što efikasniji način dobile potrebne vrijednosti materijalnih parametara, razvit će se tehnika određivanja parametara temeljena na genetskom algoritmu. U cilju optimizacije procedure dobivanja parametara zadanog materijala, razvit će se procedura složenog genetskog algoritma te njegovi operatori, uz primjenu adekvatne funkcije cilja optimizacijskog postupka.Zbog fleksibilnosti i robusnosti predložene metodologije karakterizacije materijala, moguća je njena primjenjivost i na karakterizaciju ponašanja i drugih nekonvencionalnih i inovativnih materijala kompleksnog ponašanja. U tu svrhu prikupit će se i sistematizirati rezultati relevantnih publiciranih eksperimentalnih ispitivanja materijala te stvoriti pretpostavke za karakterizaciju drugih inovativnih materijala.]]></summary_hr><summary_en><![CDATA[In engineering great attention is paid to enhancing the properties of conventional and development of innovative materials. Although the research is largely focused on metals, polymers, glass, ceramics, composites, etc.., increasing interest is devoted to biological systems and materials (shells, bone, spider silk, muscle or similar) due to their characteristics that are significantly above those of conventional materials.Behavior and modeling of biological materials is complex, but as the modeling of conventional materials, it is based on the knowledge and experimental determination of their characteristics. To describe the behavior of materials, beside material model, the basic prerequisite is the identification of material parameters.It was found that for the identification of parameters of biological materials necessary for the modeling of their behavior, it is advisable to apply the evolutionary methods, especially genetic algorithm.In the project, the behavior of the neck ligaments of human spine will be characterized and modelled based on data obtained by experiments. A hyperelastic material model that can be used for compressible and incompressible materials is selected for that puprose. In order to more efficiently produce the required values of material parameters, a technique for determining the parameters based on genetic algorithm will be developed. In order to optimize the procedure to obtain the parameters specified materials, complex genetic algorithm and its operators will be developed, applying the appropriate objective function optimization procedure.Because of it&#39;s flexibility and robustness, the proposed methodology for the materials characterization is expected to be applicable to the characterization of other non-conventional and innovative materials of complex behavior. To this end, relevant published experimental results will be collected and systematized in order to create the basis for the characterization of other innovative materials.]]></summary_en></project><project>
<id>3709</id><title_hr><![CDATA[Razvoj održivog procesa prerade antitoksina ]]></title_hr><title_en><![CDATA[]]></title_en><user_id>102</user_id><user_firstLast_name>Beata Halassy</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2015-10</proposal_call><code>DOK-2015-10-8293</code><acronim><![CDATA[ANTI TOX NEW]]></acronim><duration>01.07.2018 - 01.12.2021</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Biologija, </scie_field_hr><scie_field_en>Biology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu]]></institution_hr><institution_en><![CDATA[University of Zagreb]]></institution_en><team_members_id>25068</team_members_id><team_members_names><![CDATA[ Doktorand: Sanja Mateljak Lukačević ]]></team_members_names><keywords_hr><![CDATA[antitoksin, antivenom, proteini plazme, inaktivacija virusa, (Fab&#39;)2 fragmenti]]></keywords_hr><keywords_en><![CDATA[antitoxin, antivenom, downstream processing, virus inactivation, (Fab&#39;)2 fragments]]></keywords_en><summary_hr><![CDATA[Antitoksini su antitijela životinjskog porijekla koja se koriste za liječenje predoziranja lijekovima (digoksin), virusnih infekcija (bjesnoća), neutralizaciju bakterijskih toksina (difterija, tetanus, botulizam), i liječenje posljedica ugriza životinja životinja otrovnica (zmija, paukova, škorpiona). Antitoksini se proizvode imunizacijom životinja, većinom konja i ovaca, odgovarajućim antigenom (uzvodni dio procesa), i pročišćavanjem imunoglobulina iz hiperimune životinjske plazme (nizvodni dio procesa). Održiv proces prerade životinjskih antitoksina ima i dodatnu vrijednost kao platforma za brzu proizvodnju lijekova protiv potpuno novih bolesti (npr. ebola). Cilj istraživanja je dizajnirati i pronaći optimalne uvjete za najučinkovitiji i najkompaktniji proces pročišćavanja antitoksina na bazi postojećih znanstvenih i tehnoloških dosega. Proces ćemo dizajnirati balansirajući između rastućih regulatornih zahtjeva, iskorištenja procesa (što viši) i troškova pročišćavanja (što niži). Cilj je pronaći optimalne uvjete za svaki korak pročišćavanja, istražiti učinkovitost cijelog postupka u redukciji rizika od virusne kontaminacije, i prikupiti podatke na laboratorijskoj razini koji mogu biti baza za proračune prilikom donošenja odluke za uspostavu pogona održive proizvodnje antitoksina. Istraživat ćemo po prvi put primjenjivost istovremenog taloženja i pepsinske razgradnje konjske plazme, što je pokazano za plazmu ovaca, i učinkovitost navedenog koraka u redukciji rizika od virusne kontaminacije, što još nije istraživano. Također, po prvi puta istražit ćemo primjenjivost kromatografije na monolitnim nosačima u postupcima pročišćavanja antitoksina.]]></summary_hr><summary_en><![CDATA[Antitoxin is the general name for the antibodies of animal origin used to treat for example drug overdose (digoxin), bacterial toxins (diphtheria, tetanus and botulism), viral infections (rabies) and envenoming (snake, spider and scorpion). So antitoxins are produced by immunisation of animals, mostly horse and sheep, by appropriate antigen of interest (upstream part of the process), and subsequent purification of induced immunoglobulins from the hyperimmunised animal plasma (downstream part of the process). Established cost-effective antitoxin production has an additional value serving as a platform that can be easily adapted for fast production of therapeutics to combat new emerging diseases (ebola, for example).The aim of the here proposed research is to design and optimise at the laboratory scale the most effective and most compact purification process (downstream part) based on the current scientific and technological knowledge. The process will be designed by balancing between criteria for fulfilling the growing regulatory demands, purification process yields (as high as possible) and the production costs (as low as possible). The aim is to find the optimal parameters of each purification step, to investigate the effectiveness of the designed process in reducing the risk of viral contamination, and to generate data on laboratory scale that could serve as the basis for decision making process regarding the sustainable antitoxin production plant establishment. The project will investigate for the first time the applicability of single-step simultaneous caprylic acid precipitation and peptic digestion of horse plasma, demonstrated so far only in ovine IgG purification, and the capability of this step in reducing the risk of viral contamination, that has not been investigated yet. Further on, the applicability of monolithic chromatographic supports (convective interaction media) in the process of antitoxin purification will be explored for the first time.]]></summary_en></project><project>
<id>3711</id><title_hr><![CDATA[Struktura i dinamika egzotičnih femto-sustava]]></title_hr><title_en><![CDATA[]]></title_en><user_id>11296</user_id><user_firstLast_name>Nils Paar</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2015-10</proposal_call><code>DOK-2015-10-6612</code><acronim><![CDATA[STRUDEF]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, </scie_field_hr><scie_field_en>Physics, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>12571</team_members_id><team_members_names><![CDATA[ Doktorand: Deni Vale ]]></team_members_names><keywords_hr><![CDATA[egzotične jezgre, energijski  funkcional gustoće, kolektivno gibanje, fisija, beta raspad, gibanje velikih amplituda]]></keywords_hr><keywords_en><![CDATA[exotic nuclei, energy density functional, nuclear collective motion, fission, beta decay, large amplitude motion]]></keywords_en><summary_hr><![CDATA[Osnovni cilj ovog projekta je razviti i primijeniti novi teorijski pristup, zasnovan na relativističkom nuklearnom energijskom funkcionalu gustoće (RNEDF) koji  omogućuje mikroskopski opis strukture i dinamike kvantnih sustava na femtometarskoj skali, te omogućuje precizan opis egzotičnih femto-sustava daleko od doline stabilnosti koji još nisu dostupni u eksperimentu. Radi se o jezgrama čija struktura i dinamika pokazuju egzotična svojstva, npr. veličinu i oblik vrlo različite od najbližih stabilnih jezgara, ili egzotične modove kolektivnog pubuđenja i raspada. Istraživački projekt uključuje razvoj teorijskog formalizma i pripadajućih modela na temelju RNEDF-a radi ostvarenja sljedećih ciljeva: (i) razviti pouzdanije funkcionale s unaprijeđenom efektivnom masom blizu Fermi površine i poboljšanim spin-orbit međudjelovanjem u izovektorskom kanalu, (ii) omogućiti kvantitativni opis statističke neodređenosti i korelacija između nuklearnih svojstava pomoću analize kovarijanci, (iii) opisati pobuđenja malih amplituda pomoću metode konačnih amplituda i vezanjima sa složenim konfiguracijama, (iv) nadograditi metodu generatorskih koordinata za gibanje velikih amplituda, (v) istražiti fenomene koegzistencije oblika i prijelaza između različitih oblika jezgara, (vi) proučiti strukturu i stabilnost superteških jezgara i proces fisije (vii) istražiti astrofizički značajne nuklearne procese koji uključuju slabu interakciju. Predviđen je razvoj naprednih teorijskih metoda za rješavanje izazova koje predstavljaju sadašnji i budući ubrzivači snopova nestabilnih iona, odnosno razumijevanje rijetkih jezgara daleko od stabilnosti koje igraju značajnu ulogu u sintezi svih stabilnih kemijskih elemenata koji danas postoje na Zemlji. Ključni pristup za ostvarenje znanstvenih ciljeva i povećanje prediktivne snage za opis egzotičnih femto-sustava je razvoj i primjena učinkovitih računalnih alata i metoda naprednog računarstva i njihova primjena na distribuiranim računalnim sustavima.]]></summary_hr><summary_en><![CDATA[The goal of this project is to develop and apply a novel theoretical framework, based on Relativistic Nuclear Energy Density Functional (RNEDF) that enables microscopic modeling of the structure and dynamics of quantum systems at the femtometer scale, and provides accurate predictions for exotic femtosystems far from stability that are not yet accessible in experiment. These nuclei have exotic or unusual structural and dynamical properties such as, for instance, sizes and shapes very different from their nearest stable nuclei, or exotic modes of collective excitation and decay by particle emission. The project research includes development of the framework based on the RNEDF with specific aims to (i) develop a more reliable functional with enhanced effective mass near the Fermi surface and improved spin-orbit interaction in the isovector channel, (ii) provide quantitative description of statistical uncertainties and correlations of nuclear properties using covariance analysis, (iii) to describe low-amplitude motion using finite amplitude method and couplings with complex configurations, (iv) upgrade the generator-coordinate method framework for large amplitude motion , (v) explore phenomena of shape coexistence and shape transitions, (vi) study the structure and stability of superheavy nuclei and fission process, (vii) explore astrophysically relevant nuclear processes including weak interaction. This will require the development of advanced theoretical methods to resolve the challenge posed by the current and future large-scale radioactive ion beam facilities, namely the understanding of rare nuclei far from stability that are precursors in the synthesis of all stable nuclear species on Earth. A key ingredient in achieving the theoretical goal of increased predictive power for exotic femtosystems is development and application of efficient computational tools and methods of scientific computing using distributed computer systems.]]></summary_en></project><project>
<id>3713</id><title_hr><![CDATA[Ultrazvučni sustav za određivanje parametara kompleksnih materijala u nelinearnim uvjetima rada]]></title_hr><title_en><![CDATA[]]></title_en><user_id>146</user_id><user_firstLast_name>Antonio Petošić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2015-10</proposal_call><code>DOK-2015-10-3950</code><acronim><![CDATA[ULTRASNON]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Elektrotehnika, </scie_field_hr><scie_field_en>Electrical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id>21320</team_members_id><team_members_names><![CDATA[ Doktorand: Petar Franček ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[material parameters, ultrasound, modular measurement system, nonlinear effects, effciency factor]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[The main objective of this project is to develop a new measurement procedure and to construct a modular measurement system for determination of complex material parameters that are used in ultrasound (US) systems  which are working in the nonlinear conditions. The materials&#39; parameters in existing US systems used in biomedicine and industry are determined at low excitation levels assuming linear physical principles and consistent thermodynamical conditions. This is different from real operating conditions where range of applied powers and types of excitation signals is various and very often far away from linear. The neglect of these nonlinearities in active and passive materials, used in the complete US system construction process, leads to the problem of the US systems’ efficiency factor in the nonlinear driving conditions. The construction of modular measurement system with included and modified interferometry and time of flight principle with added new measurement procedure is crucial for developing novel US systems with higher electroacoustic efficiency factors. The new method is based on tracking the resonant frequency changes of the nonlinear electro-mechanical-acoustical system for determination complex material parameters. The new modular measurement system will enable exposure of materials to the US fields with various driving conditions. Tracking the resonant frequency changes of excitated loading medium sample (active piezoceramic or passive construction elements or different types of loading mediums) is novel method for determination of material parameters when nonlinear effects appear in the loading mediums. As a result of more precise constructive material parameters determination, three prototypes of US systems with probes and electronic excitation circuits for applications in biomedicine and industry, with obtained higher electroacoustic efficiency factors will be developed, constructed and tested during this project.]]></summary_en></project><project>
<id>3714</id><title_hr><![CDATA[Molekularna, epidemiolološka i klinička obilježja zaraze HIV-om u Hrvatskoj]]></title_hr><title_en><![CDATA[]]></title_en><user_id>1084</user_id><user_firstLast_name>Josip Begovac</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2015-10</proposal_call><code>DOK-2015-10-4738</code><acronim><![CDATA[MEKHH/MECHC]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Kliničke medicinske znanosti, </scie_field_hr><scie_field_en>Clinical sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb School of Medicine]]></institution_en><team_members_id>19506</team_members_id><team_members_names><![CDATA[ Doktorand: Maja Trupković ]]></team_members_names><keywords_hr><![CDATA[HIV, AIDS, supklinička ateroskleroza, podtipovi HIV-a, rezistancija, antiretrovirusni lijekovi, preživljenje]]></keywords_hr><keywords_en><![CDATA[HIV. AIDS, subclinical atherosclerosis, HIV subtypes, resistance, antiretrovirals, survival]]></keywords_en><summary_hr><![CDATA[Hrvatska ima centraliziranu skrb za osobe zaražene HIV-om, svi bolesnici se liječe u Klinici za infektivne bolesti u Zagrebu. Opći cilj projekta je nastaviti dugotrajno prikupljati kliničke, molekularne, laboratorijske i terapijske podatke u skupini bolesnika zaraženih HIV-om iz Hrvatske te: (1) procijeniti čimbenike u svezi s kliničkim, imunološkim i virusološkim tijekom zaraze HIV-om i (2) nastaviti razvijati sustav molekularnog nadzora uz definiranje promejna koje se tijekom vremena događaju u zarazi HIV-om u Hrvatskoj. Opći istraživanja uključuje prospektivno istraživanje demografskih, kliničkih, terapijskih, virusoloških i laboratorijskih podatke u osoba zaraženih HIV-om u Hrvatskoj, u svrhu određivanja dugotrajnog virusološkog, imunološkog i kliničkog ishoda kao i trendove u molekularnoj epidemiologiji zaraze HIV-om. Specifični ciljevi istraživanja uključuju također: procjenu nazočnosti supkliničke ateroskleroze u bolesnika zaraženih HIV-om koji primaju ART te ispitanika koji nisu zaraženi HIV-om, analizirati učinak prehtrambenih navika, posebno mediteranske prehrane na supkliničku aterosklerozu, odrediti učestalost subtipova HIV-a u novodijagnosticiranih bolesnika koji su se uključili u kliničku skrb u razdoblju od 2014 do 2017.g., analizirati transmisijske klastere subtipa B i non-B subtipova HIV-a, te odrediti prevalenciju i obrasce mutacija povezanih s primarnom rezistencijom HIV-a na lijekove. U istraživanje će se uključiti sve osobe koje se liječe u KIB, a dale su pismenu privolu za istraživanje. Uključiti će se osobe koje su bile u skrbi u razdoblju 1997 do 2017. Procjenjuje se da će ukupno 700-800 osoba biti uključeno u analize. Očekujemo da će rezultati ovog projekta doprinijeti unaprjeđivanju kvalitete skrbi bolesnika zaraženih HIV-om kao i razvoju strategija uspješnije prevencije zaraze HIV-om.]]></summary_hr><summary_en><![CDATA[Croatia as a centralized system of care and all HIV infected persons are treated at the University Hospital of Infectious Diseases (UHID) in Zagreb. ln general terms, the objective of the project s to continue a long-term, prospective collection of biomolecular, clinical, laboratory and therapeutic data on a cohort of HIV infected patients from Croatia in order to (1) assess the factors associated with the clinical, immunological and virological course of HIV infection and (2) continue to provide and develop a molecular surveillance system to describe temporal changes of HIV-infection in in Croatia. The primary aim is to determine the long-term virological, immunological and clinical outcome as well as trends in the molecular epidemiology of HIV infection. We will also specifically address issues such as: subclinical atherosclerosis in both HIV-infected patients taking ART and non-HIV-infected participants; the influence of food habits, specifically adherence to the Mediterranean diet on subclinical atherosclerosis; the frequency of HIV subtypes among newly-diagnosed patients entering clinical care in the period 2014-2017; transmission clusters of B and non-B subtypes; prevalence and patterns of transmitted drug resistance (TDR) to different classes of antiretroviral drug resistance in newly-diagnosed HIV-infected persons in the period 2014-2017 with the impact of transmission clusters on the prevalence of TDR. The study population will include all patients in care at UHID who provided written consent. Patient eligible for analysis were or will be seen in care at UHID from 1997 to 2017. It is estimated that a total of about 700-800 will be included into the analyses. The results of this project are expected to significantly contribute to the improvement of HIV clinical care as well as to the development of improved strategies for prevention of HIV infection.]]></summary_en></project><project>
<id>3716</id><title_hr><![CDATA[Role of Activating Transcription Factor 3 and related molecules in the activation of spinal cord endogenous stem/progenitor cells]]></title_hr><title_en><![CDATA[]]></title_en><user_id>5326</user_id><user_firstLast_name>Miranda Mladinić Pejatović</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2015-10</proposal_call><code>DOK-2015-10-3441</code><acronim><![CDATA[]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Biologija, </scie_field_hr><scie_field_en>Biology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Fakultet biotehnologije i razvoja lijekova]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Biotechnology and Drug Development]]></institution_en><team_members_id>19201</team_members_id><team_members_names><![CDATA[ Doktorand: Antonela Petrović ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>3717</id><title_hr><![CDATA[Supramolekulska sinteza samo-organizirajućih funkcionalnih nanomaterijala i kompleksnih kemijskih sustava]]></title_hr><title_en><![CDATA[]]></title_en><user_id>348</user_id><user_firstLast_name>Leo Frkanec</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2015-10</proposal_call><code>DOK-2015-10-7592</code><acronim><![CDATA[SInFONIA]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, </scie_field_hr><scie_field_en>Chemistry, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>21266</team_members_id><team_members_names><![CDATA[ Doktorand: Tomislav Gregorić ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[Supramolecular Chemistry, Self-Assembly, Gels, Hydrogels, Functional Materials, Nanomaterials, Molecular Surface Recognition, Complex Chemical Systems]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[The aim of this project proposal is supramolecular synthesis of self-assembled functional materials and study thus created complex chemical systems. Such systems exhibit a complex array of morphologies and dynamics and have a huge potential for new applications in areas ranging from materials science to medicine. The bottom–up synthesis of highly complex functional materials from simple modular blocks is an intriguing area of research. These hierarchically assembled systems extend beyond the individual molecule and rely on non-covalent interactions in a directed self-assembly process. Intrinsic properties of the materials can be modified by exploiting dynamic and specific uni-directional interactions among building blocks, thus allowing construction of novel supramolecular structures. These supramolecular networks belong to a novel category of soft biomaterials exhibiting attractive properties. Research in this project will include the formation of dynamic polymeric networks through molecular recognition and complex assembly formation. Self-assembly of small organic molecules is a suitable method for synthesis of organic nano-structured materials. LWM organo- and hydro-gels with oxalamide units represent construction units with high H-bonding potential; they are self-complementary, capable of unidirectional H-bonding suited for construction of self-assembled with fibrous morphology. In continuation of our previous research the attention will be focused on two main areas of research 1. nanofabrication; preparation of new materials by polymerization through cross linking the gel network or transcript to the TEOS and development of new organic materials that incorporate photoactive functional groups, and 2. bioinspired supramolecular systems for detection and degradation of fibrous supramolecular aggregates, such as Aß-protein and amyloid plaques (that are a major cause of Alzheimer’s disease) and vesicles functionalization for  surface molecular recognition studies. ]]></summary_en></project><project>
<id>3721</id><title_hr><![CDATA[Probiotici i starter kulture – površinski proteini i bakteriocini]]></title_hr><title_en><![CDATA[]]></title_en><user_id>796</user_id><user_firstLast_name>Jasna Beganović</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2015-10</proposal_call><code>DOK-2015-10-4303</code><acronim><![CDATA[PRO-S]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Biotehnologija, </scie_field_hr><scie_field_en>Biotechnology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prehrambeno-biotehnološki fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Food Technology and Biotechnology]]></institution_en><team_members_id>21384</team_members_id><team_members_names><![CDATA[ Doktorand: Katarina Zorić ]]></team_members_names><keywords_hr><![CDATA[probiotici, starter kulture, bakteriocini, površinski proteini, funkcionalnost]]></keywords_hr><keywords_en><![CDATA[probiotics, starter cultures, bacteriocins, surface proteins, functionality]]></keywords_en><summary_hr><![CDATA[Svrha predloženog istraživanja je razvoj nove generacije probiotika i funkcionalnih starter kultura, detaljno okarakteriziranih, sa specifičnim svojstvima kao što je proizvodnja funkcionalnih površinskih S-proteina i bakteriocina. Od ukupno dvjesto različitih autohtonih sojeva bakterija mliječne kiseline (BMK), izoliranih iz tradicionalnih fermentiranih proizvoda u Laboratoriju za tehnologiju antibiotika, enzima, probiotika i starter kultura Prehrambeno-biotehnološkog fakulteta Sveučilišta u Zagrebu, samo pet Lactobacillus sojeva eksprimira sloj S-proteina na površini svojih stanica. Istraživanja će se provoditi s ciljem razjašnjavanja uloge S-proteina u stanicama Lactobacillus sojeva, posebno u važnim probiotičkim svojstvima, kao što su adhezija, kompetitivna ekskluzija patogena i interakcije s imunološkim sustavom domaćina. Istraživanja će također biti usmjerena na proizvodnju bakteriocina autohtonih sojeva BMK, mehanizma njihovog djelovanja i indukciju sinteze bakteriocina. Izolirani autohtoni sojevi BMK bit će dalje ispitivani obzirom na fiziološka i tehnološka svojstva važna pri odabiru funkcionalnih starter kultura. Obzirom da su tradicionalno proizvedeni fermentirani proizvodi bogat izvor novih i potencijalno zanimljivih mikrobnih sojeva poželjnih genetičkih, metabolizamskih i tehnoloških svojstava, okarakterizirani sojevi BMK, proizvedeni kao mikroinkapsulirane i liofilizirane funkcionalne starter kulture će doprinijeti kvaliteti i sigurnosti tradicionalnih fermentacijskih procesa kao i formulaciji inovativnih funkcionalnih proizvoda. Oboje je od velikog značaja za prehrambenu industriju s aspekta proizvodnje hrane s posebno definiranim funkcionalnim (probiotičkim) svojstvima.]]></summary_hr><summary_en><![CDATA[The proposed research is aimed to deliver new generation of probiotics and functional starter cultures, thoughtfully characterised and with specific features such as production of functional surface (S)-layer proteins and bacteriocins. Among more than 200 different autochthonous lactic acid bacteria (LAB) strains isolated from artisanal fermented food products in Laboratory of Antibiotic, Enzyme, Probiotic and Starter Culture Technologies, Faculty of Food Technology, University of Zagreb, only five Lactobacillus strains are found to possess S-layer proteins. This research is intended to clarify the role of S-layer proteins in cells of Lactobacillus species, particularly in important probiotic properties such as adhesion, competitive pathogen exclusion and interactions with host immune system. Researches will also be directed towards bacteriocin production by autochthonous LAB strains, mode of antimicrobial action, as well as the induction of bacteriocin production. Isolated autochthonous LAB strains will be further examined for their physiological and technological properties important during their selection as functional starter cultures. Since artisanal fermented foods are a rich source of new and potentially interesting microbial strains with considerable genetic, metabolic and technological properties, well-defined autochthonous LAB strains, produced as microencapsulated and lyophilised functional starter cultures, will contribute to safety and quality of traditional food fermentation processes and to formulate innovative functional products. Both are of great importance for the food industry in aspect of designing the food with specially defined functional (probiotic) properties.]]></summary_en></project><project>
<id>3722</id><title_hr><![CDATA[Molekularni aspekti oksidativnih procesa u stanicama]]></title_hr><title_en><![CDATA[]]></title_en><user_id>440</user_id><user_firstLast_name>Mario Vazdar</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2015-10</proposal_call><code>DOK-2015-10-3352</code><acronim><![CDATA[MolOxStress]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, </scie_field_hr><scie_field_en>Chemistry, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>21289</team_members_id><team_members_names><![CDATA[ Doktorand: Sanja Škulj ]]></team_members_names><keywords_hr><![CDATA[oksidativni stres, reaktivni aldehidi, membranski proteini, organska sinteza, molekulska dinamika, kvantnokemijski računi]]></keywords_hr><keywords_en><![CDATA[oxidative stress, reactive aldehydes, membrane proteins, organic synthesis, molecular dynamics, quantum chemical calculations]]></keywords_en><summary_hr><![CDATA[Cilj predloženog projekta je otkrivanje molekulskih detalja procesa vezanih za prijenos protona i oksidativni stres u mitohindrijima, organelima lociranim u stanicama koji služe za pretvorbu kisika i vanjskih izvora energije u adenozin trifosfat (ATP), u procesu oksidativne fosforilacije. Tijekom ovog procesa, osjetljiva energetska ravnoteža se održava pumpanjem protona izvan unutarnje mitohindrijske membrane uz pomoć lanca elektron-transport proteina te njihovog vraćanja unutra u procesu sinteze ATP-a pomoću ATP sintaze. Ova ravnoteža nije uvijek optimalna i posebna klasa proteina smještenih unutar unutrašnje mitohondrijske membrane, tzv. razvezujući proteini (&#39;&#39;uncoupling proteins&#39;&#39;), služe za kontrolu prijenosa protona kroz membranu.Posebna pažnja posvetit će se studiju reaktivnosti različitih reaktivnih aldehida koji se stvaraju tijekom oksidativnog stresa unutar fosfolipidnog dvosloja, prema razvezujućim proteinima. Ove štetne reakcije povećavaju aktivnost razvezujućih proteina koji dovodi i do povećanog protoka protona kroz unutrašnju mitohondrijsku membranu koja time mijenja energetsku ravnotežu unutar stanice što dovodi do raznih opasnih bolesti, poput raka, dijabetesa tipa 2 i pretilosti.Projekt će koristiti najnovije računske pristupe uz kombinaciju kvantnokemijskih računa i simulacija molekulske dinamike. Nadalje, teorijski proračuni će se nadopuniti modelnim eksperimentima gdje će se ispitati sintetizirani reaktivni aldehidi sa svrhom daljnjeg razumijevanja reaktvnosti, kao i dodatne provjere računskih rezultata.Ovo istraživanje će doprinijeti očuvanju zdravlja pružajući zajednici bolje razumijevanje osnovnih principa i mehanizama pomoću kojih opasni aldehidi reagiraju s razvezujućim proteinima. Predložit će se nove ideje s ciljem boljeg razumijevanja funkcije razvezujućih proteina, razvijanja lijekova za unaprijeđenje zdravlja te umanjivanju efekata oksidativnih procesa.]]></summary_hr><summary_en><![CDATA[The proposed project aims to unravel the molecular details of the processes connected with proton transfer and oxidative stress in mitochondria, organelles located in cells which convert oxygen and external energy supply into adenosine triphosphate (ATP) in the process of oxidative phosphorylation. During this process, a delicate energy balance is maintained between pumping of protons outside the inner mitochondrial membrane by the electron-transport chain proteins and transferring them back inside in the process of ATP synthesis by the ATP synthase. This balance is not always optimal and a special class of membrane proteins located inside inner mitochondrial membranes, called uncoupling proteins, serves as a control of the proton transfer rate through the membrane. Particular attention will be paid to the study of the reactivity of various reactive aldehydes generated during oxidative stress within phospholipid bilayers, towards uncoupling proteins. These deleterious reactions enhance the activity of uncoupling proteins resulting in the increased proton leak through inner mitochondrial membrane which in turn modifies energy balance inside the cell leading to various harmful diseases, such as cancer, type 2 diabetes and obesity. The project application uses the &#39;&#39;state of the art&#39;&#39; computational approach by combining quantum chemical calculations and molecular dynamics simulations. Also, the theoretical work is expanded with the experimental work where model compounds will be synthesized and used in model reaction systems to further understand and cross-check the simulation results. The research will endorse health by providing the community better understanding of the underlying principles and mechanisms by which deleterious aldehydes react with uncoupling proteins. The novel ideas will be proposed in order to better understand the function of uncoupling proteins, to develop drugs for improving health and to minimize effects due to oxidation processes.]]></summary_en></project><project>
<id>3723</id><title_hr><![CDATA[Liječenje neuropatske boli stimulacijom spinalnog ganglija]]></title_hr><title_en><![CDATA[]]></title_en><user_id>4510</user_id><user_firstLast_name>Livia Puljak</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2015-10</proposal_call><code>DOK-2015-10-2774</code><acronim><![CDATA[NeuroMod]]></acronim><duration></duration><status>Prekinut</status><financ_value></financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Splitu, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Split School of Medicine]]></institution_en><team_members_id>21335</team_members_id><team_members_names><![CDATA[ Doktorand: Ivana Vuka ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[neuropathic pain, nerve injury, neuromodulation, dorsal root ganglion, ganglionic field stimulation, T-junction, microelectrode arrays]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Neuropathic pain is a debilitating disease of the somatosensory system that has a huge socio-economic impact. Numerous studies, including those from our laboratory have established that the injured dorsal root ganglion (DRG) is the important site for pathophysiologic changes that lead to development of neuropathic pain. Although DRG neurons are critical for the onset of neuropathic pain, there are no relevant clinical treatments for neuropathic pain that target this organ. With this proposal we aim to prove that neurostimulation techniques can be successfully used to manipulate neuronal function at the level of experimentally injured DRGs. In order to test this hypothesis we will construct a fully implantable neuronal stimulator for freely moving rats, devise an implantation technique and define stimulation protocols. This stimulator will be tested in rats with two types of experimentally induced nerve injury; spinal nerve ligation and carrageenan-induced inflammation model. Since this invasive procedure bears substantial risk of inflammation and other adverse neural tissue response, which can induce pain per se, we will also investigate connective tissue fibrosis and neuroinflammatory response in neural tissue of DRG and dorsal horn. The effect of the stimulation on excitability of injured DRG neurons will also be tested in vitro. Our last aim builds on our previous study in which we showed that neuronal injury may disable T-junction filtering and thereby increase the net conduction of afferent traffic. With this proposal we will test whether stimulation can modulate filtering properties of DRG T-junction. This will be addressed using recordings from injured sensory neurons of dorsal root ganglia excised from adult rats, and recently developed methodology that will allow us to electrically visualize action potential propagation in DRG neurons grown over custom microelectrode arrays.]]></summary_en></project><project>
<id>3726</id><title_hr><![CDATA[Porezna politika i fiskalna konsolidacija u Hrvatskoj]]></title_hr><title_en><![CDATA[]]></title_en><user_id>3265</user_id><user_firstLast_name>Hrvoje Šimović</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2015-10</proposal_call><code>DOK-2015-10-1342</code><acronim><![CDATA[TPFCC]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Ekonomija, </scie_field_hr><scie_field_en>Economy, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Ekonomski fakultet u Zagrebu]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Economics and Business]]></institution_en><team_members_id>22597</team_members_id><team_members_names><![CDATA[ Doktorand: Antonija Buljan ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[tax policy, tax system, tax structure, fiscal consolidation, Croatia]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[The project is dealing with a tax policy problem Croatia has been tackling with in times of its fiscal consolidation as to ensure enough fiscal revenues, support long-term growth and maintain and even increase the equity of the tax system. The research starts with an extensive expert opinion survey about the state and perspectives of Croatian tax systems, which will be extended to Slovenia and Bosnia and Herzegovina in order to do relevant cross analysis of the obtained results. This survey will be followed by some public attitude surveys concerning relevant tax issues.The macroeconomic effects of fiscal consolidation measures in Croatia, with the emphasis on tax measures, will be analyzed at different government levels as well as the effects of tax structure on the economic growth. The research will be broadened to encompass other (mostly region) countries.It is expected that the research team with their in-depth tax policy analyses will pinpoint different aspects of crucial tax policy issues in Croatia with problem-solving recommendations regarding financial transaction tax, real estate tax, environmental taxation, flat tax and some other base broadening and tax expenditure issues. ]]></summary_en></project><project>
<id>3727</id><title_hr><![CDATA[Poticanje inovativnog ponašanja zaposlenika u javnom sektoru primjenom intervencija u dizajnu posla]]></title_hr><title_en><![CDATA[]]></title_en><user_id>5575</user_id><user_firstLast_name>Tomislav Hernaus</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2015-10</proposal_call><code>DOK-2015-10-8299</code><acronim><![CDATA[INPUBWORK]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Ekonomija, </scie_field_hr><scie_field_en>Economy, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Ekonomski fakultet u Zagrebu]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Economics and Business]]></institution_en><team_members_id>22840</team_members_id><team_members_names><![CDATA[ Doktorand: Matija Marić ]]></team_members_names><keywords_hr><![CDATA[dizajn posla, inovativno ponašanje zaposlenika, intervencije posla, javna poduzeća, longitudinalno istraživanje, kvazi-eksperimenti, tjedni dnevnici]]></keywords_hr><keywords_en><![CDATA[work design, innovative work behaviour, job interventions, state-owned enterprises, longitudinal research, quasi-experiments, weekly diary study]]></keywords_en><summary_hr><![CDATA[Optimalno korištenje inovacijskog potencijala zaposlenika predstavlja glavni izazov upravljanja ljudskim potencijalima u današnjem globalnom i hiperkonkurentnom poslovnom okruženju. Nedavna istraživanja potvrdila su ulogu karakteristika posla kao ključnog prethodnika i usmjeravajućeg elementa za poticanje inovativnog ponašanja zaposlenika. Ipak, još uvijek ne znamo kako se različite karakteristike posla mijenjaju tijekom vremena, kakav je njihov međusobni odnos, koje su karakteristike najvažnije te kako ih je moguće uspješno mijenjati.Inovativno ponašanje zaposlenika posebice je važno i nedovoljno istraženo u javnim poduzećima. Nažalost, njihovi zaposlenici u velikoj mjeri su demotivirani i neproduktivni, dok su njihove organizacije neefikasne i nekonkurentne. Takvi negativni stavovi i loše radne prakse ograničavaju inovativno ponašanje i pružaju neadekvatne poslovne rezultate. Slijedom toga, svrha projekta je istražiti što potiče inovacije na razini posla. Planiramo provesti dubinsko istraživanje prakse dizajna posla u Republici Hrvatskoj. Analizirat ćemo karakteristike zadataka, socijalne i kognitivne aspekte poslova unutar četiri javna poduzeća od posebnog državnog značaja.Prilagođene intervencije posla (menadžerski, idiosinkratski dogovori, dorađivanje posla) bit će provedene u stvarnom radnom okruženju, zajedno s trofaznim longitudinalnim istraživanjem putem dnevnika i kvazi-eksperimentalnim nacrtom istraživanja. Pomoću intervencija u dizajnu posla, određene karakteristike posla bit će prilagođene i usklađene s osobnim i pozicijskim karakteristikama zaposlenika. Ostvarivanjem sklada između osobe i posla, potaknut će se inovativno ponašanje javnih zaposlenika, a time će se neizravno povećati i organizacijska inovativnost. Točnije, participativno akcijsko istraživanje osigurat će višu razinu generiranja ideja te dovesti do češćih procesnih unapređenja u promatranim javnim poduzećima, s mogućim učinkom prelijevanja i na druga javna poduzeća, a na dobrobit cjelokupnog hrvatskog gospodarstva.]]></summary_hr><summary_en><![CDATA[Optimally utilizing the innovative potential of employees has become a major human resource challenge within the global and highly competitive business environment. Recent studies have confirmed job characteristics as a critical antecedent and a driving force for innovative work behaviour. However, we still know little about how work design factors change over time, how they interact, which are the most important, and how they can be successfully changed.Innovative work behaviour is especially needed and understudied within state-owned enterprises. Their employees are largely unmotivated and unproductive, and organisations are ineffective and non-competitive. Such negative work attitudes and practices hinder innovative work behaviour and result in non-adequate business results. Therefore, the main purpose of the project is to explore the idea of what enhances innovation at the work level. We plan to carry out an in-depth research on work design in Croatia. We will analyse task-, social- and cognitive aspects of jobs within four strategically important state-owned enterprises. Tailored job interventions (e.g., managerial, I-deals, job crafting) will be used in a real life work setting, supplemented with three-way longitudinal diary study and quasi-experimental research design. Through work design interventions, particular set of job characteristics will be modified and aligned with personal- and job-related differences. By achieving a person-job fit, we will be able to foster innovative work behaviour of public employees, and thereby indirectly increase the level of organisational innovativeness. Specifically, the participatory action research applied will provide increased level of idea generation and will result in more frequent process improvements within sampled state-owned enterprises, with a potential spillover effect on other SOEs and significant benefits for the Croatian economy as a whole.]]></summary_en></project><project>
<id>3728</id><title_hr><![CDATA[SINTEZA I CITOSTATSKA ISPITIVANJA  BIBLIOTEKE NOVIH DUŠIKOVIH HETEROCIKLA]]></title_hr><title_en><![CDATA[]]></title_en><user_id>2767</user_id><user_firstLast_name>Krešimir Pavelić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2015-10</proposal_call><code>DOK-2015-10-8011</code><acronim><![CDATA[SCIENcENTRY]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Biotehnologija, </scie_field_hr><scie_field_en>Biotechnology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Fakultet biotehnologije i razvoja lijekova]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Biotechnology and Drug Development]]></institution_en><team_members_id>22656</team_members_id><team_members_names><![CDATA[ Doktorand: Anja Harej ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[1,2,3-triazole-heterocycles hybrids, benzimidazoles, benzothiazoles, synthesis, cytostatic activity, in silico and docking analysis, DNA binding]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Cancer is one of the most serious health problems of a worldwide dimension. One in three of the population develops cancer at some time in their lives and one in four dies from this disease. The main problems in antitumor chemotherapy are drug resistance and side effects on normal tissues. In the recent years a tremendous growth was witnessed in synthesis and development of vast number and types of new heterocyclic antitumor agents, with an emphasis on creation of new drugs with better selectivity or activity. The latter are indeed major requirements in development of novel anticancer drugs. The proposed scientific project is highly interdisciplinary and objective-oriented with the principal aim to develop the novel lead compounds with pronounced and selective anticancer activity that would be used for further phases of drug development.To achieve the principal aim following specific tasks are foreseen. The goal of the first one is to synthesize small-compound library (Classes A–H) comprising new conjugates of pseudopurines, coumarines and quinolines with 1,2,3-triazole scaffold, N-acyclic 5-unsaturated pyrimidine derivatives, amino-, amido- and amidino substituted benzimidazole, benzothiazole and benzo[b]thieno-2-carboxamide derivatives. Molecule library will be synthesized using modern synthetic approaches such as click chemistry, palladium mediated cross-coupling, eco-friendly microwave assisted and photochemical reactions as well as classical organic synthetic methods. The aim of the second task is to predict plausible biological targets and pharmacological activities using cheminformatics/in silico analysis. The third task is to perform cytostatic evaluations based on which hit molecules with desired biological effect will be selected for structure optimization that will be subsequently carried out. Finally, the molecular mechanism studies are anticipated for the most effective compounds from synthesized N-heterocycles library.]]></summary_en></project><project>
<id>3729</id><title_hr><![CDATA[Glikozilacija plazmatskih proteina u razumijevanju dijabetesa tipa 1]]></title_hr><title_en><![CDATA[]]></title_en><user_id>11174</user_id><user_firstLast_name>Olga Gornik</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2015-10</proposal_call><code>DOK-2015-10-3293</code><acronim><![CDATA[GLYCO-T1D]]></acronim><duration>16.10.2016 - 16.06.2022</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Farmacija, </scie_field_hr><scie_field_en>Pharmaceutical sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Farmaceutsko-biokemijski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Pharmacy and Biochemistry]]></institution_en><team_members_id>24884</team_members_id><team_members_names><![CDATA[ Doktorand: Najda Selak ]]></team_members_names><keywords_hr><![CDATA[glikozilacija, dijabetes tipa 1, glikom, genom, predispozicija]]></keywords_hr><keywords_en><![CDATA[glycosylation, type 1 diabetes, gycome, genome, predisposition]]></keywords_en><summary_hr><![CDATA[Glikozilacija je važna posttranslacijska modifikacija proteina koja često ima utjecaj na funkciju proteina. Proces glikozilacije je izrazito složen i reguliran mrežom gena koji su pokazali povezanost i s različitim bolestima. Glikani predstavljaju dobre potencijalne dijagnostičke alatke te doprinose razumijevanju etiologije mnogih bolesti. Značaj glikozilacije u dijabetesu tipa 1 (T1D) do sada nije istražen.T1D je oblik dijabetesa koji se javlja zbog autoimunog uništavanja stanica koje proizvode inzulin. Nedostatak brige za ove pacijente može biti letalan, stoga svako novo saznanje o ovoj bolesti predstavlja značajan doprinos. Povezivanje promjena u glikomu s genotipovima moglo bi rezultirati važnim rezultatima te potencijalno svrstati osobe u skupine bazirano na njihovim glikanskim i genomskim osobinama. Ova informacija bi se također mogla upotrijebiti za predviđanje rizika za razvoj bolesti kod pojedinca. Stoga ćemo u ovom istraživanju spojiti naša iskustva u genetičkim analizama i analitici glikana kako bismo identificirali glikanske promjene specifične za T1D za koje možemo kolerirati glikom i genom.Kako bi ostvarili cilj ovog istraživanja, analizirat ćemo glikane plazme obitelji s barem dvoje bolesnih potomaka te također zdravim potomcima. Uslijed ovisnosti glikana o godinama, roditelji neće biti uključeni u ovu studiju, pa će se tako analizirati preko 4500 dostupnih uzoraka. Za sve sudionike postoje rezultati genotipizacije.Glikani će se analizirati visokoprotočnom MALDI-TOF MS tehnologijom koja pruža pouzdanu analizu glikoma te je trenutno najsuvremenija glikoanalitička metoda.Uslijed neupitne uloge glikana u patološkim stanjima, izuzetno dobro definirane populacije izabrane za ovo istraživanje te upotrebu suvremene i osjetljive tehnologije, ovo istraživanje rezultirat će novim znanjima koja će unaprijediti razumijevanje i dijagnostiku dijabetesa tipa 1.]]></summary_hr><summary_en><![CDATA[Glycosylation is a posttranslational modification that provides great proteomic diversity and often impact protein function. This process is regulated by a network of genes, many of which show pleiotropy with different diseases. Glycans present a great potential diagnostic tool as well as contribute to the understanding of the aetiology of diseases. The importance of glycosylation in type 1 diabetes mellitus (T1D) has not been addressed by now. T1D is a form of diabetes that results from the autoimmune destruction of the insulin-producing beta cells in the pancreas. Lack of care for these patients can be lethal, so any new knowledge about the development of this disease would represent an important contribution. Integrating glycomic changes with the subjects’ known genotypes could generate powerful and important results, potentially defining groups based on their glycome and genomic characteristics. This information may also be used to predict an unaffected individual’s risk of disease. This is why, in this study, we will combine expertise in genetic analysis and analyses of plasma glycome in order to search for the glycomic changes that are specific to T1D and for which we can correlate glycome and genome.To reach the goals of this study, we will analyze plasma glycomes of families with both diabetic siblings and unaffected siblings. Due to the age-related changes in glycosylation, parents will not be included in this study, so over 4500 samples will be analysed. All these samples have their genotyping performed.Glycomes will be analysed using MALDI-TOF-MS technology, which provides reliable analysis and presents the best available glycoanalytic tool.Thus, due to the undeniable role of glycans in pathological conditions, the well characterized population selected for this study and the use of highly modern and sensitive technology, this study will result in important new insights that will advance the comprehension and management of type 1 diabetes mellitus.]]></summary_en></project><project>
<id>3730</id><title_hr><![CDATA[Fitohormoni u abiotskom stresu kupusnjača: mehanizam tolerancije i primjena]]></title_hr><title_en><![CDATA[]]></title_en><user_id>791</user_id><user_firstLast_name>Branka Salopek Sondi</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2015-10</proposal_call><code>DOK-2015-10-9629</code><acronim><![CDATA[PhytoBraCro]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Biologija, </scie_field_hr><scie_field_en>Biology, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>17895</team_members_id><team_members_names><![CDATA[ Doktorand: Ida Linić ]]></team_members_names><keywords_hr><![CDATA[kupusnjače, suša, solni stres, auksin, hormoni stresa]]></keywords_hr><keywords_en><![CDATA[Brassica crops, drought, salinity stress, auxin, stress hormons]]></keywords_en><summary_hr><![CDATA[Biljne vrste iz porodice Brassicaceae su široko rasprostranjene povrtne kulture. Abiotički stres poput suše i povećanog saliniteta tla su primarni uzroci gubitka u poljoprivrednoj proizvodnji. Fitohormoni su ključni za prilagodbu biljaka nepovoljnim uvjetima regulirajući procese kao što su fotosinteza, aktivnosti antioksidacijskih enzima, akumulacija sekundarnih metabolita, promjene u ekspresiji gena itd. Biljni hormoni auksini djeluju kao regulatori u većini odgovora biljaka na stres kroz složene interakcije s hormonima stresa: salicilnom (SA), abscizinskom (ABA), jasmonskom (JA) kiselinom i brazinosteroidima (BRA). Cilj ovog projekta je istražiti mehanizme odgovora odabranih biljaka iz porodice krstašica na stres uzrokovan sušom i povećanim salinitetom: kineski kupus (Brassica rapa), bijeli kupus (B. oleracea var. capitata) i raštika (B. oleracea var. acephala) kroz integrativni pristup koji podrazumjeva metode mjerenja fotosinteze, biokemijske metode dijagnostike stresa, metabolomiku (analize biljnih hormona i sekundarnih metabolita), molekularna funkcionalna te aplikativna istraživanja. Poseban naglasak će biti na ulozi fitohormona auksina i interakcijama s hormonima stresa (SA, ABA, JA, BRA) u odgovoru na sušu i povećani salinitet te potencijalnim mehanizmima tolerancije. Biljni hormoni biti će analizirani UHPLC-MS/MS metodom. Sekundarni metaboliti, polifenoli i glukozinolati biti će mjereni spektrofotometrijski i UHPLC-MS/MS metodama. Funkcionalna istraživanja će biti provedena na linijama uročnjaka (Arabidopsis thaliana) koje imaju mutacije u genima odgovornim za homeostazu auksina (gh3, ilr). Rezultati analiza bioaktivnih spojeva (hormona i sekundarnih metabolita) će biti korelirani s fiziološkim i biokemijskim podatcima (parametri fotosinteze, ROS, antioksidacijski enzimi, prolin, glutation, karbonili). Biljni hormoni stresa će biti ispitani kao potencijalni biostimulatori tolerancije na sušu i povećani salinitet aplikacijom na list i tretmanom korijena.]]></summary_hr><summary_en><![CDATA[Crops from the family of Brassicaceae are commercially widely spread vegetables. Abiotic stresses such as salinity and drought are the primary causes of crop loss worldwide. Phytohormones are crucial for the plant ability to adapt to abiotic stress by mediating a wide range of adaptive responses: photosynthesis modification, increased antioxidant activities, secondary metabolites accumulation, changes in gene expression. Phytohormone auxin regulates the majority of plant stress responses through interactions with stress hormones salicylic acid (SA), abscisic acid (ABA), jasmonic acid (JA), and brassinosteroids (BRA). The aim of this proposal is to investigate the abiotic stress responses of selected Brassica crops (Brassica rapa. ssp. pekinesis, Brassica oleracea var. capitata and Brassica oleracea var. acephala) to drought and salinity stress through integrative research approach comprising biophysical methods of photosynthesis measurements, biochemical methods of stress diagnostics, metabolomics (plant hormones and secondary metabolites) and molecular functional research. Particular focus will be placed to the role of auxin and its interactions with stress hormones (SA, ABA, JA and BRA) in stress responses and potential mechanisms of tolerance. Phytohormones auxin, SA, JA, ABA and BRA will be analyzed by UHPLC-MS/MS. Secondary metabolites, polyphenols and glucosinolates will be measured by spectrophotometry and UHPLC-MS/MS. In order to shed light on auxin homeostasis in abiotic stress, functional research will be performed by using Arabidopsis thaliana lines for genes of auxin reversible conjugation (GH3 and ILR). Results of hormonal analyses will be correlated with basic physiological and biochemical parameters (photosynthesis parameters, ROS level, antioxidant enzymes, proline, glutathione, protein carbonyl level). Finally, stress plant hormones will be investigate as potential biostimulator of abiotic stress tolerance by foliar spray and root treatment.]]></summary_en></project><project>
<id>3735</id><title_hr><![CDATA[Recommender System for Service-oriented Architecture ]]></title_hr><title_en><![CDATA[]]></title_en><user_id>7793</user_id><user_firstLast_name>Siniša Srbljić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2015-10</proposal_call><code>DOK-2015-10-8617</code><acronim><![CDATA[RSOA]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Računarstvo, </scie_field_hr><scie_field_en>Computer sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id>22589</team_members_id><team_members_names><![CDATA[ Doktorand: Adrian Satja Kurdija ]]></team_members_names><keywords_hr><![CDATA[sustav preporuke, arhitektura zansnovana na uslugama, kompozicije usluga, pomoć pri programskom oblikovanju, funkcijska i nefunkcijska svojstva]]></keywords_hr><keywords_en><![CDATA[recommender system, service-oriented architecture, service compositions, development assistance, functional and non-functional properties]]></keywords_en><summary_hr><![CDATA[Razvojem platformi vezanih uz računalne oblake (engl. Cloud computing) i internet stvari (engl. Internet of Things), sustavi utemeljeni na arhitekturi zasnovanoj na uslugama (engl. service-oriented architecture - SOA) dobivaju sve više na značaju. SOA je arhitekturalni stil koji pruža smjernice razvoja slabo povezanih raspodijeljenih sustava. Središnji objekt SOA-e su usluge, samostalni primjenski programi, kojima se pristupa korištenjem standardiziranih sučelja. Jedna od glavnih prednosti SOA-e jest mogućnost povezivanja više usluga u kompozitne sustave (kompozicije usluga). Unatoč jasnim prednostima, uz razvoj kompozicija usluga veže se niz poteškoća vezanih uz ostvarivanje funkcijskih i nefunkcijskih svojstava građenog sustava. Trenutni istraživački rezultati ne pružaju odgovor kako učinkovito graditi kompozicije usluga u slučaju kad su dostupni vrlo veliki imenici usluga te kad je složenost tijeka izvođenje građene kompozicije vrlo velika. 	Cilj ovog istraživačkog projekta je izraditi cjelovit sustav preporuke čija je uloga pojednostaviti izgradnju kompozicija usluga pružanjem pomoći programskim inženjerima u ostvarivanju funkcijskih i nefunkcijskih ciljeva. Naši prijašnji istraživački rezultati pokazuju da je izgradnja takvog sustava moguća. Kroz ovaj projekt cilj nam je proširiti postojeće rezultate s novim metodama preporuke posebno prilagođenim sustavima zasnovanima na arhitekturalnom stilu SOA.	U području funkcijskih ciljeva, predloženi sustav preporuke će omogućiti automatsku preporuku usluga zasnovanu na morfološkoj strukturi građene kompozicije usluga. Osim toga, sustav će primjenom tehnologija dijeljenja znanja omogućiti korisnicima da pronađu odgovarajuću ljudsku pomoć. U području nefunkcijskih svojstava, primijenit će se skup statističkih metoda za procjenu pouzdanosti atomarnih (gradivih) usluga. Zaključno, sustav će omogućiti učinkovito unapređivanje nefunkcijskih svojstva izgrađene kompozicije s obzirom na složenost tijeka izvođenja.]]></summary_hr><summary_en><![CDATA[In recent years, systems based on service-oriented architecture (SOA) have been gaining a lot of traction due to proliferation of cloud computing and Internet of Things (IoT) platforms. SOA is an architectural style that provides guidelines for development of loosely coupled distributed systems. The concept relies on services, self-contained applications which can be consumed using well-established interfaces. One of the most pronounced benefits of SOA is the ability to combine multiple services into a component-based application (service composition). Despite having clear advantages, service composition development entails issues when it comes to reaching both the required functional and non-functional application goals. Specifically the current research results do not offer an answer how to build service compositions efficiently when faced with large service repositories and very complex service workflows.	The goal of this project is to put forward a comprehensive recommender system aimed at simplifying development of service compositions by assisting developers in reaching both functional and non-functional application goals. Our previous research efforts, demonstrate that designing such a recommender is feasible. As part of this project we want to extend the preliminary research with novel recommender methods suited for SOA-based systems. Regarding functional properties, the proposed recommender is to facilitate automatic service recommendations based on the morphological structure of the constructed application. Furthermore, the recommender is to utilize knowledge sharing technologies to assist in enlisting most adequate human help. In the domain of non-functional properties, a set of methods used to determine reliability of atomic services based on statistical approaches will be applied. Finally, a method for efficient improvement of service composition’s non-functional properties will be utilized.]]></summary_en></project><project>
<id>3739</id><title_hr><![CDATA[Uloga fosfoinozitida u nastanku trombocita]]></title_hr><title_en><![CDATA[]]></title_en><user_id>35</user_id><user_firstLast_name>Antonija Jurak Begonja</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2015-10</proposal_call><code>DOK-2015-10-1946</code><acronim><![CDATA[MkPI]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Fakultet biotehnologije i razvoja lijekova]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Biotechnology and Drug Development]]></institution_en><team_members_id>20883</team_members_id><team_members_names><![CDATA[ Doktorand: Ivana Bertović ]]></team_members_names><keywords_hr><![CDATA[megakariociti, trombociti, trombopoeza, endocitoza, fosfoinozitidi]]></keywords_hr><keywords_en><![CDATA[megakaryocytes, platelets, thrombopoiesis, endocytosis, phosphoinositides]]></keywords_en><summary_hr><![CDATA[Trombociti su neophodni za hemostazu te također posreduju u procesima različitih bolesti uključujući upale, metastaze, aterosklerozu. Liječenje leukemija i drugih malignih oboljenja ili transplantacije organa često dovode do smanjenja broja trombocita, te predstavljaju rizik od krvarenja. Trombociti nastaju iz citoplazme megakariocita (MK) u koštanoj srži u procesu trombopoeze. MK prolaze složen proces sazrijevanja koji vodi ka stvaranju dugih, razgranatih citoplazmatskih struktura – protrombocita. Molekularni mehanizmi koji reguliraju ove citoplazmatske promjene MK-a u velikoj mjeri su nepoznati. Naša preliminarna istraživanja pokazuju da određena vrsta fosfoinozitida (PI), fosfatidilinozitol 3-monofosfat (PI3P) ima glavnu ulogu u formiranju protrombocita u primarnim kulturama MK-a. U stanicama PI3P se nalazi u ranim endosomima i sudjeluje u endosomskom prometu. Naša je hipoteza da membranski promet reguliran PI3P-om u endocitnom putu znatno pridonosi biogenezi trombocita. Predloženi projekt istražit će točnu ulogu PI3P u stvaranju protrombocita. Koristit ćemo genetski napravljene  fluorescentne probe, tehniku koja se temelji na proteinskim domenama fuzioniranim s fluorescentnim proteinom eksprimiranim s retrovirusa, kako bi odredili lokalizaciju u stvarnom vremenu različitih PI u MK-ima i protrombocitima. Istražit ćemo kako interferencija PI3P funkcije utječe na sazrijevanje MK te utvrditi je li defekt ograničen na endosomski odjeljak. U svrhu utvrđivanja mehanizma djelovanja PI3P-a koristit ćemo genetski i farmakološki pristup kako bi ispitali je li progresija ranih u kasne endosome nužna za stvaranje trombocita. Osim toga, identificirat ćemo proteine koji vežu PI3P regulirajući endosomsku dinamiku važnu za stvaranje protrombocita. Ovo će istraživanje doprinijeti našem razumijevanju osnovnih molekularnih procesa trombopoeze koji bi mogli doprinijeti novim terapijskim strategijama u liječenju trombocitopenije.]]></summary_hr><summary_en><![CDATA[Platelets are essential for hemostasis and they also mediate diverse disease processes including inflammation, metastasis, atherosclerosis. Cancer and leukemia treatments or organ transplants often lead to reduced platelet numbers, putting patients at risk of bleedings. Platelets derive from cytoplasm of megakaryocytes (MKs) in the bone marrow in a process called thrombopoiesis. MKs undergo complex maturation process that leads towards extension of long, branched cytoplasmic structures called proplatelets that eventually release platelets. Molecular mechanisms that govern these elaborate cytoplasmic changes of MKs remain largely unknown. Based on primary MKs our preliminary studies show that one type of phosphoinositides (PIs), phosphatidylinositol 3-monophosphate (PI3P) has a major role in proplatelet formation. PI3P is concentrated in early endosomes and is involved in endosomal trafficking. Our hypothesis is that PI3P regulation of membrane traffic in the endocytic pathway contributes significantly to platelet biogenesis. This proposed project will reveal the exact role of PI3P in proplatelet formation. We will use genetically engineered fluorescent probes, a technique based on protein domains fused with fluorescent protein expressed from retroviruses, to define spatial and temporal localization of different PIs in MKs and proplatelets. We will investigate if interference of PI3P function affects MK maturation and examine if defect is confined to endosomal compartment. To determine mechanism of PI3P action we will use genetic and pharmacologic approaches to examine if progression of early to late endosomes is needed for platelet genesis. In addition, we will identify proteins  that act in concert with PI3P to regulate endosomal dynamics important for proplatelet formation. These studies will contribute to our understanding of basic molecular processes underlying thrombopoieses and might lead towards novel therapeutic strategies in treatment of thrombocytopenia.]]></summary_en></project><project>
<id>3740</id><title_hr><![CDATA[Molekularni mehanizmi alternativne raspodjele elektrona u fotosintezi]]></title_hr><title_en><![CDATA[]]></title_en><user_id>455</user_id><user_firstLast_name>Hrvoje Fulgosi</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2015-10</proposal_call><code>DOK-2015-10-9583</code><acronim><![CDATA[PHOTOSYNTH]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Biologija, </scie_field_hr><scie_field_en>Biology, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>22598</team_members_id><team_members_names><![CDATA[ Doktorand: Anja  Rac ]]></team_members_names><keywords_hr><![CDATA[oksigena fotosinteza, kloroplasti, tok elektrona, FNR, ROS, rodanaza, sortiranje proteina, transgenične biljke, Arabidopsis thaliana]]></keywords_hr><keywords_en><![CDATA[oxygenic photosynthesis, chloroplasts, electron flow, FNR, ROS, rhodanese, protein sorting, transgenic plants, Arabidopsis thaliana]]></keywords_en><summary_hr><![CDATA[Konačni prijenos fotosintetskih elektrona s feredoksina na NADP+ odvija se putem enzima feredoksin:NADP+ oksidoreduktaze (FNR). FNR je privučen na tilakoide pomoću integralnog proteina tilakoidnih membrane sličnog rodanazama, TROL-a, i solubilnog proteina Tic62. TROL je nedavno okarakterizirala naša grupa. FNR također predstavlja poveznicu između svjetlosnih reakcija i generalnog metabolizma (kao što je fiksacija ugljika, metabolizam dušika, biosinteza masnih kiselina i klorofila). U ovom projektu pratimo sudbinu elektrona nizvodno od fotosustava I u odsustvu TROL-a. Da bismo proučili in vivo funkcije TROL-a i njegovih domena koristit ćemo genski “knock-out” i “knock-in” pristup u modelnoj biljci Arabidopsis thaliana. Naša hipoteza je da je FNR-TROL interakcija dinamičma, slična interakciji FNR-Tic62, i usklađena s mijenjanjem uvjeta osvjetljenja u okolišu. Nadalje, predlažemo da je lumenu izložena rodanazna domena TROL-a uključena u prepoznavanje redoks signala, dok je prolinom bogata pokretna spona, ispred motiva koji veže FNR za membranu, odgovorna za dinamičko vezanje FNR-a i/ili privlačenje FNR-a u različite membranske domene. Koristit ćemo razrađene biokemijske i biofizičke pristupe za kvantifikaciju stvaranja slobodnih radikala i protoka i raspodjele elektrona u različitim mutantama TROL-a. Cilj nam je pokazati da je točka grananja TROL-FNR integrirana u biljni odgovor na stress. Također, želimo pokazati da dinamičko vezanje i otpuštanje FNR-a s TROL-a može kontrolirati protok elektrona prije aktivacije puta pseudocikličkog prijenosa elektrona. Ovaj mehanizam vjerojatno nije uočen u dosadašnjim modelima toka elektrona u oksigenoj fotosintezi.]]></summary_hr><summary_en><![CDATA[In photosynthesis, final electron transfer from ferredoxin to NADP+ is accomplished by the flavo enzyme ferredoxin:NADP+ oxidoreductase (FNR). FNR is recruited to thylakoid membranes via integral membrane thylakoid rodanese-like protein TROL and soluble Tic62. TROL protein has recently been characterized by our group. FNR also represents a link between light-driven reactions and general metabolism (e.g. carbon fixation, nitrogen metabolism and fatty acid and chlorophyll biosynthesis). In this project, we address the fate of electrons downstream of photosystem I when TROL is absent. We will employ gene knock-out and knock-in approaches in the model plant Arabidopsis thaliana to study in vivo functions of TROL and its domains. We hypothesize that the interaction of FNR with TROL is dynamic, similar to FNR-Tic62 association, and in synchrony with changing environmental light conditions. Further, we propose that thylakoid lumen-exposed rhodanese domain of TROL is involved in perception of redox signals, while proline-rich swivel preceding FNR membrane attachment motif is responsible for the dynamic FNR biding and/or recruitment of FNR into different membrane domains. We will use elaborate biochemical and biophysical approaches to quantify free radical formation and electron flow and partitioning in various TROL mutants. We will aim to demonstrate that TROL-FNR branch point is integrated into plant stress responses. Finally, we want to demonstrate that the dynamic binding and release of FNR from TROL can control the flow of electrons prior to activation of the pseudo-cyclic electron transfer pathway. This mechanism may have been overlooked in present models of electron flow in oxygenic photosynthesis. ]]></summary_en></project><project>
<id>3741</id><title_hr><![CDATA[Jezična obrada u odraslih govornika]]></title_hr><title_en><![CDATA[]]></title_en><user_id>6436</user_id><user_firstLast_name>Melita Kovačević</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2015-10</proposal_call><code>DOK-2015-10-8899</code><acronim><![CDATA[ALP]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Logopedija, </scie_field_hr><scie_field_en>Logopedics, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Edukacijsko-rehabilitacijski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Education and Rehabilitation Sciences]]></institution_en><team_members_id>20388</team_members_id><team_members_names><![CDATA[ Doktorand: Ana  Matić ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[language processing, adult and elderly population, language disorders, executive functions, linguistic aphasiology]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Adult Language Processing project is intended to address psycholinguistic and neurolinguistic aspects of the aging population in Croatia. As an installation research project it will help set up an interdisciplinary and multidisciplinary research group that would tackle all aspects of the language processing in adults and in the aging population. Clinical groups (patients with aphasias, dementias and dyslexia) will be included into the project; language breakdown in these clinical groups helps in the study of language processing in healthy adults and vice versa. It is generally assumed that the subtle changes in language processing in the aging population arise from the cognitive decay related to executive functions, not language per se. The decrease in the processing speed influences language processes that require fast execution or simultaneity. This results in a typical pattern of changes, different from the ones in clinical populations. Therefore, executive functions in these groups will be studied in order to build a comprehensive model of adult language processing. Theories of language processing (namely, Role and Reference Grammar - RRG) will be considered to define specific traces of language processing that assume fast execution or simultaneity and therefore should be the most vulnerable in aging population. These traces will be defined and described which will put Croatian into a cross-linguistic perspective in contemporary studies of linguistic aphasiology and provide coherent picture of age related changes in adult language system.  ]]></summary_en></project><project>
<id>3744</id><title_hr><![CDATA[ADAPTIVNA PARAMETRIZACIJA PROMJENJIVIH 3D GEOMETRIJA KOD OPTIMIZACIJE OBLIKA I  BEZMREŽNOG NUMERIČKOG MODELIRANJA]]></title_hr><title_en><![CDATA[]]></title_en><user_id>3851</user_id><user_firstLast_name>Damir Vučina</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2015-10</proposal_call><code>DOK-2015-10-6189</code><acronim><![CDATA[Optimal3D]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Strojarstvo, </scie_field_hr><scie_field_en>Mechnical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Splitu, Fakultet elektrotehnike, strojarstva i brodogradnje]]></institution_hr><institution_en><![CDATA[University of Split, Faculty of Electrical Engineering, Mechanical Engineering and Naval Architecture]]></institution_en><team_members_id>21278</team_members_id><team_members_names><![CDATA[ Doktorand: Anđela Bartulović ]]></team_members_names><keywords_hr><![CDATA[Adaptivna parametrizacija oblika, 3D geometrijsko modeliranje, particioniranje po značajkama, optimizacija oblika, bezmrežne metode]]></keywords_hr><keywords_en><![CDATA[Adaptive shape parameterization, 3D geometric modeling, Feature-based partitioning, Shape optimization, Meshless methods]]></keywords_en><summary_hr><![CDATA[Glavni cilj projekta je razvoj numerički efikasnog i dinamički adaptivnog parametarskog zapisa oblika koji donosi povećanu mogućnost modeliranja 3D oblika kako sam po sebi tako i za funkcije oblika u numeričkim metodama.Početni zapis oblika je oblak 3D točaka kakav se dobije sustavom digitalizacije oblika (3D optički sustav za skeniranje visoke razlučivosti). Matematička parametrizacija oblaka točaka zasnivati će se na parametarskim plohama. Integralna kao i po dijelovima povezana parcijalna parametrizacija biti će istražene i uspoređene.Proučavati će se dinamički aspekti parametrizacije. Oblik i posebno topologija objekta će se mijenjati u kvazivremenu simulacije/optimizacije. Za vrijeme procesa, rubovi i vrhovi mogu nestati, a novi se mogu pojaviti, zbog čega parametrizacija treba biti samostalno prilagodljiva na takve promjene.Proučavati će se strategije za redukciju parametarskog skupa nepoznanica na temelju dopuštenih graničnih vrijednosti pogrešaka u području značajki i na temelju ukupne normirane greške. Ove strategije uključuju prilagodljivu preraspodjelu kontrolnih točaka koristeći procedure za detekciju značajki temeljene na omjeru vlastitih vrijednosti i procjeni nagiba i zakrivljenosti. Vrednovati će se prilagodljiva podjela plohe cjelokupnog objekta na dijelove na temelju različitih kriterija.   Proces optimizacije uključuje opsežne izračune odnosno rješavanje problema polja opisanog parcijalnim diferencijalnim jednadžbama. Navedeni aspekti modeliranja oblika također se primjenjuju u bezmrežnim metodama gdje funkcija na domeni određuje numeričko rješenje danog problema polja. Razmotrit će se bezmrežne metode temeljene na &#39;&#39;oblaku&#39;&#39; čvorova koje su značajno manje osjetljive na promjene u konfiguraciji materijala.]]></summary_hr><summary_en><![CDATA[The project focuses on developing numerically efficient and dynamically adaptive parametric representations of shape which autonomously provide increased modeling capacity for the 3D shape itself and for the shape functions in numerical methods. The initial shape iteration will start from 3D point clouds, possibly resulting from shape digitization (existing high-resolution optical scanning system). Mathematical parameterization of the point clouds will be based on parametric surfaces. Integral as well as chained piecewise surfaces will be explored and compared. Dynamic aspects of the parameterizations will be studied. The shape and possibly topology of the object will be changing in simulation/ optimization quasi-time iterations. During the process, edges and peaks may disappear and new ones may arise, whereby the parameterization must be autonomously adaptable to such changes.Strategies for controlled reductions of the parameterization data-sets based on permissible threshold values for peak error and cumulative error norms will also be studied. These strategies will include adaptive re-allocation of the control points using feature recognition procedures (edges, peaks) based on eigenvalue ratios and slope and curvature estimators. Adaptive partitioning of the overall object surface based on different criteria will be evaluated.The optimization process involves extensive field calculations i.e. solving field problems governed by partial differential equations. The above shape modeling aspects also apply with meshless methods where a function across the domain determines the numerical solution of a given field problem. The option applied here will be meshless methods which are based on a nodes “cloud” and are dramatically less sensitive to the change in a material configuration.]]></summary_en></project><project>
<id>3745</id><title_hr><![CDATA[Razvoj numeričkih modela armirano-betonskih i kamenih zidanih konstrukcija izloženih potresnom opterećenju zasnovanih na diskretnim pukotinama]]></title_hr><title_en><![CDATA[]]></title_en><user_id>5683</user_id><user_firstLast_name>Željana Nikolić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2015-10</proposal_call><code>DOK-2015-10-5825</code><acronim><![CDATA[SeismoNuMod]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Građevinarstvo, </scie_field_hr><scie_field_en>Civil engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Splitu Fakultet građevinarstva, arhitekture i geodezije]]></institution_hr><institution_en><![CDATA[University of Split, Faculty of Civil Engineering, Architecture and Geodesy]]></institution_en><team_members_id>25469</team_members_id><team_members_names><![CDATA[ Doktorand: Jadran Čarija ]]></team_members_names><keywords_hr><![CDATA[Numeričko modeliranje,  Potresno djelovanje, AB konstrukcije, Kamene zidane konstrukcije, Diskretne pukotine]]></keywords_hr><keywords_en><![CDATA[Numerical modelling, Earthquake loading, RC structures, Stone masonry structures, Discrete cracks]]></keywords_en><summary_hr><![CDATA[Pojava pukotina je jedan od dominantnih uzroka nelinearnosti u krtim i kvazi-konstrukcijama koja dovodi do pojave lokaliziranog sloma i predstavlja ozbiljan izazov u numeričkom modeliranju. Proces nastanka pukotina započinje na mikrorazini, a progresivnim srastanjem stvaraju se makropukotine koje predstavljaju diskontinuitet u materijalu. Precizno modeliranje otvaranja i zatvaranja pukotina jedan je od ključnih čimbenika koji utječe na pouzdanost modela za analizu konstrukcija, posebno onih izloženih potresnom opterećenju. Sofisticirani numerički modeli temeljeni na metodi odgovora u vremenu i inkrementalnoj dinamičkoj analizi imaju značajnu ulogu u simulaciji ponašanja takvih konstrukcija prije i poslije sloma. U ovom projektu planira se razvoj dvaju nelinearnih modela za inkrementalnu dinamičku analizu konstrukcija zasnovanih na diskretnim pukotinama s različitim pristupima u rješavanju ovog problema. Jedan će biti novi 3D model za potresno opterećene armirano-betonske i kamene zidane konstrukcije ojačane trnovima i klamfama, zasnovan na metodi kombiniranih konačno-diskretnih elemenata kod koje pukotine nastaju u kontaktnim elementima smještenima duž rubova konačnih elemenata. Model će omogućiti raspucavanje, dinamičku interakciju razdvojenih elementa i praćenje ponašanja konstrukcije prije i nakon sloma. Drugi model će biti zasnovan na metodi konačnih elementa s ugrađenim diskontinuitetom i ugrađenom armaturom koja omogućuje nastanak pukotina neovisno o mreži konačnih elemenata i primijenit će se na armirano-betonske konstrukcije. Validacija razvijenih modela će se provesti usporedbom s dostupnim rezultatima eksperimentalnih istraživanja, dok se u svrhu validacije modela za kamene zidane konstrukcije planiraju provesti vlastiti eksperimenti na potresnoj platformi. Na kraju će se provesti usporedne analize ponašanja konstrukcija s oba modela.]]></summary_hr><summary_en><![CDATA[Crack opening is one of the dominant causes of nonlinearity in brittle and quasi-brittle structures which leads to localized failure and stands out as a serious challenge in numerical modelling. The process of crack initiation starts at a micro-scale, and with progressive growth, micro-cracks coalesce into macro-cracks representing discontinuities in the material. Therefore, a realistic modelling of crack initiation and propagation is one of the key factors that affect the reliability of the model for analysing the structures, especially those subjected to earthquakes. Sophisticated numerical models based on time dependent and incremental dynamic analysis can play an important role in simulating the behaviour of such structures before and after collapse. This project aims to develop two nonlinear numerical models for incremental dynamic analysis of structures based on the model of discrete cracks. The first one will be a novel 3D model for reinforced concrete and stone masonry structures strengthened with clamps and bolts based on the combined finite discrete element method where the cracks are modelled through the contact elements implemented between finite elements. The model enables crack initiation and propagation, dynamic interaction of separate elements and monitoring of structural behaviour before and after the collapse. The second model will be based on the finite element method with embedded discontinuity and embedded reinforcement, which allows for crack initiation and propagation independent of finite element mesh and will be applied to reinforced concrete structures. The novel numerical models for reinforced concrete structures will be validated by available experimental research, while our own experiments are planned to be performed at shaking table for the validation of stone masonry structure model. Thereafter, the comparative analysis of the behaviour of real structures with both models will be conducted.]]></summary_en></project><project>
<id>3746</id><title_hr><![CDATA[(PHOENIX) People for tHe eurOpean bio-ENery mIX]]></title_hr><title_en><![CDATA[]]></title_en><user_id>5040</user_id><user_firstLast_name>Milan Vujanović</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2015-10</proposal_call><code>DOK-2015-10-4216</code><acronim><![CDATA[]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Strojarstvo, </scie_field_hr><scie_field_en>Mechnical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet strojarstva i brodogradnje]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Mechanical Engineering and Naval Architecture]]></institution_en><team_members_id>22608</team_members_id><team_members_names><![CDATA[ Doktorand: Tibor Bešenić ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>3747</id><title_hr><![CDATA[Zelena  otapala  za  zelene  tehnologije]]></title_hr><title_en><![CDATA[]]></title_en><user_id>3228</user_id><user_firstLast_name>Ivana Radojčić Redovniković</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2015-10</proposal_call><code>DOK-2015-10-3478</code><acronim><![CDATA[GREEN]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Biotehnologija, </scie_field_hr><scie_field_en>Biotechnology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prehrambeno-biotehnološki fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Food Technology and Biotechnology]]></institution_en><team_members_id>21346</team_members_id><team_members_names><![CDATA[ Doktorand: Manuela  Panić ]]></team_members_names><keywords_hr><![CDATA[biokataliza, biološkiaktivni spojevi, eutektična  otapala, ionske kapljevine, pročišćavanje tekućih goriva]]></keywords_hr><keywords_en><![CDATA[biocatalysis, biologically active compounds, deep euectic solvents, fuel purification, ionic liquids]]></keywords_en><summary_hr><![CDATA[Posljednjih su nekoliko godina globalna ekonomska kriza,rastuće cijene hrane, energije i drugih roba te povećana svijesto utjecaju čovjeka na okoliš potaknuli koncept zelene ekonomijeu središte političkih, gospodarskih i znanstvenih rasprava. Uskladu s time ionske kapljevine i eutektična otapala intenzivnose istražuju s ekološkog, tehnološkog i ekonomskog gledištakao zamjena za tradicionalna organska otapala. Ciljpredloženog Projekta jest stjecanje znanja o prirodnim ionskimkapljevinama i eutektičnim otapalima dizajniranih za specifičneprocese u prehrambenoj tehnologiji, biotehnologiji i kemijskojtehnologiji. U sklopu Projekta pripravit će se ionske kapljevine ieutektična otapala iz prirodnih sirovina poput kolinijevih soli,ugljikohidrata, organskih kiselina i aminokiselina, odreditinjihova fizikalno-kemijska svojstva i toksičnost te primjeniti kaootapala u ekstrakciji biološki aktivnih spojeva iz nusproizvodaprehrambene industrije, biokatalitičkim reakcijama te procesupročišćavanja tekućih goriva. Prema našim saznanjima uRepublici Hrvatskoj jedina smo istraživačka grupa koja sesustavno bavi izučavanjem zelenih otapala, a što je u skladu sključnim ciljevima EU vezanim uz očuvanje okoliša. S tim u svezi,financiranje ovog projekta iznimno je važno za nastavak našegmultidisciplinarnog istraživanja zelenih otapala (priprava,karakterizacija i primjena) što je također od velikog interesa i zahrvatsku akademsku zajednicu. Provedbom predloženogProjekta profilirat ćemo se u vodeću grupu u područjuistraživanja prirodnih ionskih kapljevina i eutektičnih otapala, nesamo u RH već i u inozemstvu. Također, stečeno znanje moćićemo prenijeti zainteresiranim industrijskim parterima kako biimplementirali zelena otapala u postojeće i/ili nove procese.]]></summary_hr><summary_en><![CDATA[Global economic crisis, soaring commodity prices and growingawareness of humanity&#39;s impact on the environment havepushed the “green economy” concept into mainstream policydebate in recent years. Accordingly, as a promising alternativeto traditional organic solvents from both the environmental andtechnological perspectives, neoteric solvents (neoteric = new,recent, modern), ionic liquids (ILs) and deep eutectic solvents(DESs), have been dramatically expanding in popularity as anew generation of designer solvents with possible applicationsin various industrial fields. The aim of proposed Project is to gainan in-depth understanding of the natural ILs and DESs withfine-tuned properties, as well as to implement these solventsinto food technology, biotechnology and chemical technology. Within the Project ILs and DESs, based on renewable sourcessuch as cholinium salts, sugars, organic acids and amino acids,will be prepared and characterized, followed by examination oftheir applicability as solvents for extraction of phenoliccompounds from wine and oil by-product, in biocatalyticreactions and in fuel purification process. To our knowledge, inthe Republic of Croatia we are the only research group involvedin multidisciplinary and systematic approach in the investigationof ILs and DESs. Thus, proposed Project would enable ourfurther research in the field of preparation, characterization andapplication of these new green solvents, which is of greatimportance for Croatian academic community in order tosuccessfully follow the EU directives. Additionally, knowledgegained through proposed Project will profile us as the leadinggroup in the field of natural ILs and DESs research, both in theRepublic of Croatia and EU, for fostering knowledge transfer toacademia and potential industry partners. ]]></summary_en></project><project>
<id>3748</id><title_hr><![CDATA[Cerebrovaskularna regulacija tijekom apneje kod elitnih ronilaca na dah]]></title_hr><title_en><![CDATA[]]></title_en><user_id>7688</user_id><user_firstLast_name>Zeljko Dujic</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2015-10</proposal_call><code>DOK-2015-10-3719</code><acronim><![CDATA[CEREBROFLOW]]></acronim><duration>05.10.2016 - 26.06.2024</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Splitu, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Split School of Medicine]]></institution_en><team_members_id>22679</team_members_id><team_members_names><![CDATA[ Doktorand: Tanja Mijačika ]]></team_members_names><keywords_hr><![CDATA[Moždani protok krvi, moždani metabolizam, hipoksija, hiperoksija, hiperkapnija, hipokapnija]]></keywords_hr><keywords_en><![CDATA[Cerebral blood flow, cerebral metabolism, hypoxia, hyperoxia, hypercapnia, hypocapnia]]></keywords_en><summary_hr><![CDATA[Glavni cilj ovog prijedloga je da se sprovedu serije sve složenijih studija kojima bi se istražila nova fiziološka pitanja u sklopu fiziologije apneje, s posebnim naglaskom na fiziologiju mozga, te integraciju s cirkulacijskim i respiracijskim refleksima. Postavljanjem  novih znanstvenih pitanja u ovom prijedlogu želimo obogatiti i nadograditi naše razumijevanje temeljnih mehanizama moždanog protoka krvi u uvjetima teške hipoksije. Raščlanjivanje prirode odnosa između kisika, cerebralne perfuzije, moždanog metabolizma, te njihove važnosti za moždanu homeostazu je ključan korak prema razumijevanju fiziologije mozga u odnosu na ostale tjelesne sustave. Zadržavanje daha uzrokuje izniman stres za kardiovaskularni sustav i mozak, usprkos kojem elitni ronioci na dah uspijevaju tolerirati značajan pad kisika koji samo u ponekim slučajevima rezultira gubitkom svijesti (sinkopa). Mehanizmi odgovorni za adaptaciju ekstremnoj hipoksiji nam mogu poslužiti kao koristan model za istraživanje cerebrovaskularne regulacije tijekom prijetnje fiziološkoj homeostazi, kao što je to slučaj kod bolesti ili traume, tim više što je samo znanstveno istraživanje regionalne moždane perfuzije tijekom kardiorespiracijskih izazova, tjelesne aktivnosti i patoloških stanja tek u svojim začecima. Prema tomu, istraživanje regionalne cerebrovaskularne regulacije, te njene povezanosti s cirkulacijskim i respiracijskim sustavom kod zdravih, treniranih ronioca na dah će rezultirati novim uvidom u cerebrovaskularnu funkciju, kao i uvidom u integraciju ostalih sustava kod ljudi. Štoviše, rasvjetljavanje ovakvih mehanizama je od izuzetno velikog značaja za razumijevanje mnogobrojnih patoloških stanja vezanih uz arterijsku hipoksemiju i/ili promjene u viskoznosti krvi ili koncentraciji hemoglobina. ]]></summary_hr><summary_en><![CDATA[The main objective of this proposal is to propose and conduct a series of incrementally progressive studies to examine new physiological questions in apnea diving physiology, with particular focus on brain physiology and the related integration with circulatory and respiratory reflexes. Addressing the novel questions outlined in this proposal will enrich our understanding of the fundamental mechanisms governing cerebral blood flow in conditions of severe hypoxia. Characterization of these relationships between oxygen, cerebral perfusion and cerebral metabolism, and their respective importance on brain homeostasis is a fundamental step toward raising our understanding of brain physiology to that of other body systems. Breath holding exerts a potent stress to the cardiovascular system and brain, yet elite breath-hold divers are able to tolerate marked reductions in blood oxygenation that only sometimes results in loss of consciousness (syncope). The mechanisms allowing such tolerance to hypoxemic extremes may serve as a useful model for the study of cerebrovascular regulation during physiological duress often observed in trauma and disease. This is especially true given that the study of regional brain perfusion during cardiorespiratory challenges, exercise, and in pathology has only begun in the past several years. Thus, the study of regional cerebrovascular regulation and its relation to the circulatory and ventilatory in healthy, trained breath-hold divers will yield new insight into the cerebrovascular function and systems integration in humans. Moreover, elucidation of these mechanistic relationships is paramount to our comprehension of myriad pathologies associated with arterial hypoxemia and/or elevations in blood viscosity or hemoglobin levels.]]></summary_en></project><project>
<id>3749</id><title_hr><![CDATA[Održivost ekonomske politike i razvoja u Hrvatskoj]]></title_hr><title_en><![CDATA[]]></title_en><user_id>503</user_id><user_firstLast_name>Jurica Šimurina</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2015-10</proposal_call><code>DOK-2015-10-6138</code><acronim><![CDATA[SCrEPoDe]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Ekonomija, </scie_field_hr><scie_field_en>Economy, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Ekonomski fakultet u Zagrebu]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Economics and Business]]></institution_en><team_members_id>22694</team_members_id><team_members_names><![CDATA[ Doktorand: Nora Mustać ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[sustainability, economic structure, resources, public sector economics, spatial economics]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[RESEARCH QUESTION: Do Croatian economic policies lead to sustainability with respect to scarce resources, demographic changes, spatial effects and economic structure?Long term Croatian economic policy and development stem from both short term policies and long term sustainability. By combining macroeconomic and development policies, the long term objectives of sustainability of natural resources, public sector economics, demographic changes, spatial economics and overall economic structure may be achieved. Thus, the goals of this research stem from the above stand point, and include:•	Establish development policies for Croatia based on sustainable use of natural resources•	Show how change of age structure in Croatia affects fiscal sustainability and short and long run economic development•	Explore how three way interaction among increasing returns, transportation costs, and movement of factors of production affect international, regional and urban development•	Analyze structure of Croatian economy suitable for sustainable and deeper integration into the EU•	Define integrative policies which lead to sustainable development of Croatian economyFor achieving above mentioned goals, the project team is separated into four equally contributing groups and is structured as follows:1. Sustainability of economic development within the context of scarce natural resources.2. Sustainability of public sector economics and the labor market in the context of demographic changes in Croatia.3. Sustainability of the degree of centralization in the context of spatial (international, urban and regional) economics.4. Sustainability of current economic structure within the context of the EU integrationOutcomes of the research will be innovative approach to controversy of long vs. short term development and stability, as well as integrative approach to different, and thus far, insufficiently interconnected fields of economic research.]]></summary_en></project><project>
<id>3750</id><title_hr><![CDATA[Implicitna ličnost i radno ponašanje]]></title_hr><title_en><![CDATA[]]></title_en><user_id>3974</user_id><user_firstLast_name>Zvonimir Galic</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2015-10</proposal_call><code>DOK-2015-10-7149</code><acronim><![CDATA[IPAWB]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Psihologija, </scie_field_hr><scie_field_en>Psychology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Filozofski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Humanities and Social Sciences]]></institution_en><team_members_id>22773</team_members_id><team_members_names><![CDATA[ Doktorand: Mitja Ružojčić ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[implicit personality, work behavior, conditional reasoning, aggressiveness, power motive.]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Recent developments in implicit personality conceptualization and measurement could shed a new light on the relationship between personality and work behavior and help us explain, predict, and even control important aspects of work behavior. In the focus of this project are conditional reasoning measures of implicit personality that represent “a model for psychometric, conceptual, and theory based implicit association measurement” (Landy, 2008, p. 390). This measurement system is called conditional reasoning because it is based on the assumption that an individual’s reasoning is conditional on his/her personality and that these differences in reasoning can be measured with inductive reasoning tasks capturing unconscious cognitive biases that stem from individuals’ personality motives.The project aims to further advance the knowledge about the conditional reasoning method of personality measurement, and the relationship between (implicit) personality and work behavior by exploring implicit aggression and power motive. We plan to (1) test the implicit nature of conditional reasoning tests and the strength of their relationship with other implicit personality measures intended to assess similar constructs; (2) further explore the relationship between the conditional reasoning tests and work behavior by testing mediators and moderators of that relationship; (3) study how different measures of implicit and explicit personality assessing the same construct (i.e., aggressiveness and power motive) interact in explaining work behaviors. We plan to focus on aggressiveness and power motive because they have the pivotal role in explaining very important aspects of work behavior such as counterproductive work behavior and leadership.]]></summary_en></project><project>
<id>3751</id><title_hr><![CDATA[Općeslavenski lingvistički atlas (OLA) i Europski lingvistički atlas (ALE) ]]></title_hr><title_en><![CDATA[]]></title_en><user_id>18899</user_id><user_firstLast_name>Ranko Matasović</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2015-10</proposal_call><code>DOK-2015-10-8194</code><acronim><![CDATA[]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Kroatologija, </scie_field_hr><scie_field_en>Croatology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Filozofski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Humanities and Social Sciences]]></institution_en><team_members_id>29174</team_members_id><team_members_names><![CDATA[ Doktorand: Pavao Krmpotić ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>3755</id><title_hr><![CDATA[Centromerna genomika beskralješnjaka]]></title_hr><title_en><![CDATA[]]></title_en><user_id>332</user_id><user_firstLast_name>Brankica Mravinac</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2015-10</proposal_call><code>DOK-2015-10-6666</code><acronim><![CDATA[CENGEN]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Biologija, </scie_field_hr><scie_field_en>Biology, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>21386</team_members_id><team_members_names><![CDATA[ Doktorand: Tena Gržan ]]></team_members_names><keywords_hr><![CDATA[centromera, CenH3, satelitna DNA, ponovljena DNA, evolucija, kornjaši, oblići, školjkaši]]></keywords_hr><keywords_en><![CDATA[centromere, CenH3, satellite DNA, repetitive DNA, evolution, beetles, nematodes, molluscs]]></keywords_en><summary_hr><![CDATA[Centromera je domena esencijalna za razdvajanje kromosoma u staničnim diobama. Razumijevanje centromerne strukture i funkcije od velikog je značaja u biologiji, a značajno je i s biomedicinskog stajališta. Funkcionalne centromere obilježene su centromerno specifičnim proteinom sličnim histonu H3 (CenH3). Centromerni identitet određuju i genomski i epigenetički mehanizmi, koji podstiču brzu koevoluciju i vrsnu specifičnost proteina CenH3 i njemu pridruženih sekvenci DNA bez narušavanja centromerne funkcije. Složenost i varijabilnost centromernog područja uzrok su još uvijek fragmentalne percepcije centromerne genomike, koja je razrađena samo na nekoliko biljnih i životinjskih modelnih organizama. Sekvencirani genomi modelnih organizama beskralješnjacima s različitom konstitucijom centromernih regija nedavno su postali dostupni. Kornjaši roda Tribolium imaju centromere uklopljene duboko u pericentromerni heterokromatin bogat satelitnim DNA, oblići korijenovih kvržica roda Meloidogyne imaju holocentrične kromosome, dok školjkaš Crassostrea gigas ima nejednoliku razdiobu satelitnih DNA u centromerama. Glavni cilj ovog projektnog prijedloga je identificirati CenH3 i njima pridružene sekvence DNA, kao i njihove nefunkcionalne varijante kako bi se istražila genomika različito organiziranih centromera. Nadalje, biti će ispitani organizacijski i evolucijski obrasci proteina CenH3 i centromernih sekvenci DNA. Strategija istraživanja kombinira identifikaciju CenH3, kromatinsku imunoprecipitaciju (ChIP) s antitijelima na CenH3, fluorescencijsku hibridizaciju in situ (FISH), imunofuorescencijsku lokalizaciju in situ (IF) i bioinformatičke metode. Takav integrativni pristup će ponuditi informacije o ovim funkcionalno značajnim dijelovima koji najčešće nedostaju u sekvenciranim genomima i unaprijediti naše razumijevanje sinergije i koevolucije centromernih sekvenci DNA i proteinskih komponenata. ]]></summary_hr><summary_en><![CDATA[The centromere is a domain essential for chromosomal segregation in cell divisions. Understanding its structure and function is of the highest importance in biology, and also crucial from biomedical point of view. Functional centromeres are marked by centromere-specific histone H3-like proteins (CenH3). Centromere identity involves both genomic and epigenetic mechanisms, favoring rapid co-evolution and species specificity of CenH3 and associated DNA sequences without impairing the function. Complexity and variations make perception of centromere genomics still fragmental and worked out only in a few most common plant and animal model systems. Among invertebrates, sequenced genomes of model organisms with diverse constitution of centromeric regions became recently available. Tribolium beetles have centromeres embedded deeply into the satellite DNA-rich pericentromeric heterochromatin, Meloidogyne root-knot nematodes have holocentric chromosomes, while the mollusk Crassostrea gigas lacks uniform distribution of satellite DNAs in centromeres. The main goal of this research proposal is to identify CenH3 and CenH3-associated DNA sequences as well as their non-functional genomic counterparts in order to explore genomics of differently organized centromeres. In addition, organizational and evolutional aspects of CenH3 and centromeric DNA sequences will be addressed. The research strategy will combine CenH3 identification, chromatin immunoprecipitation (ChIP)-based assays using anti-CenH3 antibodies, fluorescence in situ hybridization (FISH), immunofluorescence in situ localization (IF) and the bioinformatics pipeline. Such integrative approach will help filling the gaps in functionally essential regions of sequenced genomes and will forward our understanding of the synergy and coevolution between DNA sequences and protein components in the centromeres.  ]]></summary_en></project><project>
<id>3757</id><title_hr><![CDATA[ERC StG 337283 MembranesAct]]></title_hr><title_en><![CDATA[]]></title_en><user_id>2682</user_id><user_firstLast_name>Ana-Sunčana Smith</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2015-10</proposal_call><code>DOK-2015-10-9140</code><acronim><![CDATA[]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, </scie_field_hr><scie_field_en>Physics, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>6627</team_members_id><team_members_names><![CDATA[ Doktorand: Nataša  Vučemilović-Alagić ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>3758</id><title_hr><![CDATA[Razvoj biokompatibilnih materijala na temelju hidroksiapatita za primjene u inženjerstvu koštanog tkiva ]]></title_hr><title_en><![CDATA[]]></title_en><user_id>13014</user_id><user_firstLast_name>Marica  Ivanković</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2015-10</proposal_call><code>DOK-2015-10-4272</code><acronim><![CDATA[HATEA]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Kemijsko inženjerstvo, </scie_field_hr><scie_field_en>Chemical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet kemijskog inženjerstva i tehnologije]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Chemical Engineering and Technology]]></institution_en><team_members_id>22646</team_members_id><team_members_names><![CDATA[ Doktorand: Leonard Bauer ]]></team_members_names><keywords_hr><![CDATA[inženjerstvo koštanog tkiva, skelet, hidroksiapatit, biorazgradivi polimeri, in vitro/vivo ponašanje]]></keywords_hr><keywords_en><![CDATA[bone tissue engineering, scaffold, hydroxyapatite, biodegradable polymers, in vitro/vivo behaviour]]></keywords_en><summary_hr><![CDATA[Izazov za inženjerstvo koštanog tkiva je razvoj odgovarajućih skeleta (engl. scaffold) koji omogućavaju dobru integraciju s okolnim tkivom. Posljednjih godina intenzivno se istražuje hidroksiapatit (HAp) zbog njegove kemijske i strukturne sličnosti s anorganskom matricom prirodne kosti i odlične bioaktivnosti. Nedostatak HAp-a su njegova slaba mehanička svojstva pa se obično kombinira s polimerima i metalima. U prethodnim istraživanjima pripravili smo visoko porozne skelete na temelju HAp-a i poli(?-kaprolakton)-a (PCL) korištenjem jednostavnih i ekonomičnih postupaka. In vitro istraživanja sa stanicama MC3T3-E1 pokazala su da skeleti nisu toksični i da su odgovarajuća 3D podloga za prianjanje, umnažanje i diferenciranje stanica. Provedene su i preliminarne sinteze poroznih skeleta na temelju HAp-a i kitozana. Dobiveni su vrlo obećavajući rezultati uzimajući u obzir poroznost i međusobnu povezanost pora te netoksičnost materijala.Opći cilj ovog projekta je poboljšanje mehaničkih i bioloških svojstava biokompatibilnih materijala na temelju hidroksiaptita, posebice njihove sposobnosti poticanja aktivnog stvaranja kosti. Specifični ciljevi projekta su:  (1) sustavno istražiti utjecaj vrste i količine iona elemenata u tragovima (Mn, Si, Zn, Cu..) na biološko ponašanje skeleta;  (2) istražiti ponašanje skeleta in vivo, implantiranjem odabranih skeleta u oštećenja potkoljenične kosti kunića; (3) istražiti mogućnosti kanalnog kutnog prešanja za dobivanje novih HAp/titan kompozita za primjene u inženjerstvu koštanog tkiva.  Čvrsto vjerujemo da će projekt doprinijeti boljem razumijevanju sinteze, strukture i svojstava novih materijala za primjene u inženjerstvu koštanog tkiva. Razvoj novih skeleta na temelju HAp-a može imati pozitivne implikacije za društvo u smislu tretiranja i liječenja koštanih oštećenja te tako poboljšati kvalitetu života pacijenata, posebice starijih. Nadalje, ova istraživanja mogu otvoriti vrata novim primjenama skeleta u istraživanju matičnih stanica. ]]></summary_hr><summary_en><![CDATA[The challenge of bone tissue engineering (BTE) is to develop bone scaffolds that allow a good integration with the surrounding tissues. Particular systems of interest are scaffolds based on hydroxyapatite (HAp), due to its chemical and structural similarity to the inorganic matrix of natural bone and excellent bioactivity. To overcome disadvantages such as poor mechanical properties of HAp it has been combined with polymers and metals. In our previous studies highly porous HAp and poly(?-caprolactone),(PCL),- coated HAp scaffolds were prepared using simple and inexpensive methods. In vitro cell culture studies showed that scaffolds are nontoxic and provide an adequate 3D support for the attachment, proliferation and differentiation of MC3T3-E1 cells. Some preliminary studies on preparation of HAp/chitosan scaffolds showed promising results regarding porosity and interconnectivity of pores and nontoxicity.The overall objective of this project is to investigate methods to improve mechanical and biological properties of HAp-based materials especially the ability to propagate active bone formation. The specific objectives of the project are: (1) to investigate systematically the effect of dopants (Mn, Si, Zn, Cu..) on biological performance of the scaffolds (2) to assess in vivo biological performance of scaffolds by implanting the selected scaffolds in rabbits&#39; lower legs defects. (3) to investigate the potential of equal-channel angular pressing to produce novel HAp/titanium composites for BTE applications.We strongly beleive that the research will contribute to the better understanding of the synthesis, structure and properties of scaffolds for BTE applications. Development of novel HAp-based scaffolds could have positive implications for society in terms of treating and healing bone defects, improving quality of life for trauma patients and the elderly. Additionally, the research will open the door to new applications of scaffolds in stem cells research.]]></summary_en></project><project>
<id>3759</id><title_hr><![CDATA[Kompetencijski profil akademske profesije: između novih zahtjeva i mogućnosti]]></title_hr><title_en><![CDATA[]]></title_en><user_id>380</user_id><user_firstLast_name>Jasminka Ledić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2015-10</proposal_call><code>DOK-2015-10-2376</code><acronim><![CDATA[APROFRAME]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Pedagogija, </scie_field_hr><scie_field_en>Pedagogy, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Filozofski fakultet u Rijeci]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Humanities and Social Sciences]]></institution_en><team_members_id>22747</team_members_id><team_members_names><![CDATA[ Doktorand: Ivana Miočić ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[higher education, academic profession, competence framework, academic roles, higher education policy]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Changes in social environment indicate the need for a redefinition of the academic profession’ traditional role and for its more comprehensive understanding, which leads to the requirements for the development of new competences. Research results indicate the increased scope of workload and demands for new approaches to teaching, disharmony between teaching and research, increasing administrative duties, and the insistence on a stronger connection between the academic community and social environment.This project aims to determine how academics in Croatia assess the relevance of various competences, and how they assess, perceive and interpret possession of various competences that shape contemporary academic profession. It is expected that the research results in a proposal of the academic profession’ competence framework.In the research quantitative and qualitative methodological approach (survey and semi-structured interview) will be used. The survey consists of the competence framework elements which are to be evaluated by the participants in terms of the assessment of their (1) relevance and (2) possession. The interviews will explore the deeper perception of academics and challenging issues within the framework, and gain a ‘holistic’ (comprehensive, systemic, integrated) understanding of context, while capturing data on the participants perceptions ‘from the inside’.The final definition of an integrated competence framework which includes different dimensions of the academic profession is an original research contribution. Bearing in mind that the research of the academic profession is neglected in the national research discourse, the results of this study will also be a starting point for defining recommendations for (national) educational policies. This will particularly apply to profiling the academic profession in the context of recent strategic directions in Croatia, in accordance with the requirements of the international scientific community.]]></summary_en></project><project>
<id>3760</id><title_hr><![CDATA[Uspostavljanje međukulturnih poveznica kroz prijevode dječje književnosti: tekst, kontekst, strategije]]></title_hr><title_en><![CDATA[]]></title_en><user_id>4856</user_id><user_firstLast_name>Smiljana Narančić Kovač </user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2015-10</proposal_call><code>DOK-2015-10-7206</code><acronim><![CDATA[BIBRICH]]></acronim><duration>20.10.2016 - 09.01.2022</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Filologija, </scie_field_hr><scie_field_en>Philology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Učiteljski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Teacher Education]]></institution_en><team_members_id>5328</team_members_id><team_members_names><![CDATA[ Doktorand: Corinna Jerkin ]]></team_members_names><keywords_hr><![CDATA[hrvatska dječja književnost, prijevodne strategije, pripovjedna proza, 20. stoljeće, međukulturni prijenos, kanon, diskurs, ukriženi tekst]]></keywords_hr><keywords_en><![CDATA[Croatian children&#39;s literature, translation strategies, narrative fiction, 20th century, intercultural transfer, canon, discourse, crossover text]]></keywords_en><summary_hr><![CDATA[Cilj je predloženoga projekta prikazati i objasniti ulogu i status prevedenih djela u korpusu hrvatske dječje književnosti, opisati trendove i tendencije u povijesnoj perspektivi te otkriti i protumačiti upotrijebljene prijevodne strategije. Projekt je usmjeren na prijevode pripovjedne proze na hrvatski i iz hrvatskoga na druge jezike tijekom dvadesetoga stoljeća.Međunarodna istraživanja dječje književnosti u novije se vrijeme u znatnoj mjeri okreću k poredbenoj dječjoj književnosti, fokusirajući se na analizu prijevoda, međukulturni prijenos i kontakte među jezicima i kulturama. U tome se podudaraju s prijevodnim studijima u širem smislu. Nakana je uspostaviti skupinu istraživača koja bi razvila takvo područje istraživanja u hrvatskome kontekstu, i koja će postaviti istraživačke standarde i prilagoditi primjerenu metodologiju specifičnostima opisanoga predmeta istraživanja.U planu je sastavljanje bibliografije prijevoda dječjih knjiga i ukriženih tekstova (crossover texts), tj. djela ujedno namijenjenih dječjem i odraslom čitateljstvu. Podatci će se analizirati i tumačiti s obzirom na polazišne i posredne jezike pojedinih prijevoda, povijesne trendove, izbor knjiga u odnosu na kanon dječje književnosti, nakladničke prakse i druge aspekte. Nadalje, odabrani primjeri prijevoda analizirat će se kako bi se utvrdile prijevodne strategije na različitim razinama diskursa. Razmotriti će se jezični, pripovjedni, kulturni i međukulturni aspekti s ciljem otkrivanja prijevodnih normi i strategija odomaćivanja (domestikacije). Hrvatskim će se djelima prevedenima na druge jezike posvetiti posebna pozornost.Rezultati će se analizirati i interpretirati kako bi se objasnile prijevodne tendencije, trendovi i dinamika književnih suodnosa tijekom dvadesetoga stoljeća iz hrvatske perspektive, kao i u međunarodnome kontekstu.Predloženi će projekt pripremiti temelj za dalji razvoj opisanoga područja istraživanja i za buduću širu međunarodnu suradnju.   ]]></summary_hr><summary_en><![CDATA[The proposed project aims to depict and explain the role and status of translated books within Croatian children’s literature, to describe trends and tendencies in a historical perspective, and to establish and interpret adopted translation strategies. The project focuses on translations of narrative fiction into and from Croatian over a span of a hundred years, i.e. in the 20th century. International scholarship in the field of children’s literature has recently turned towards comparative children’s literature, focusing on translation, intercultural transfer and contacts among languages and cultures. In so doing, it intersects with recent trends in translation studies in general. The proposed project aims to establish a team of researchers who would develop such an area of research in Croatia. The goal is to set research standards and fine-tune appropriate methodology.The researchers intend to assemble a bibliography of translated children’s books and crossover texts. Records will be analysed and interpreted with respect to the source and intermediary languages represented, historical trends, book selection relative to the canon of children’s literature, publishing practices and other aspects. Next, a selection of published books will be analysed for translation strategies at several levels of discourse. The researchers will address linguistic, narrative, cultural and intercultural aspects, and focus on uncovering translation norms and domestication strategies. Croatian books translated into other languages will receive special attention.Finally, the results will be analysed and interpreted to explain the documented translation flows, trends, and the dynamics of literary relationships in the 20th century, from the Croatian perspective and in the international context. The proposed project will present a sound foundation for further development of the established area of research and of a wider international cooperation in the future. ]]></summary_en></project><project>
<id>3765</id><title_hr><![CDATA[Utjecaj akvakulture na prirodne morske populacije]]></title_hr><title_en><![CDATA[]]></title_en><user_id>4254</user_id><user_firstLast_name>Ivan  Katavić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2015-10</proposal_call><code>DOK-2015-10-4913</code><acronim><![CDATA[AquaPop]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Biotehnologija, </scie_field_hr><scie_field_en>Biotechnology, </scie_field_en><institution_hr><![CDATA[Institut za oceanografiju i ribarstvo]]></institution_hr><institution_en><![CDATA[Institute of Oceanography and Fisheries]]></institution_en><team_members_id>18929</team_members_id><team_members_names><![CDATA[ Doktorand: Iva  Žužul ]]></team_members_names><keywords_hr><![CDATA[Akvakultura, utjecaj, prirodne populacije riba i školjkaša, ekološke zamke, prebjezi, genetske interakcije]]></keywords_hr><keywords_en><![CDATA[Aquaculture, Impact, Wild fish and shellfish populations, ecological traps, escapees, genetic interactions]]></keywords_en><summary_hr><![CDATA[Zbog stalnog rasta broja lokacija za uzgoj morskih organizama javlja se sveprisutna zabrinutost da marikultura kao gospodarska djelatnost može predstavljati opasnost za morsku biološku raznolikost kroz negativni utjecaj na prirodne populacije morskih organizama kao i cjelokupni morski ekosustav. Ekološke interakcije se odražavaju kroz činjenicu da kavezne uzgojne instalacije postaju nove ekološke niše za prirodne populacije ribe kod kojih promjene u fiziologiji i ponašanju su moguće. Drugi rizik za okoliš se očituje u mogućem utjecaju zbjegova uzgojne ribe iz kaveza prisutne u morskom okolišu kao rezultat slučajnog bijega iz kaveza ili namjernog poribljavanja. Pobjezi ili poribljavane jedinke iz uzgoja predstavljaju potencijalni rizik genetskoj osnovi izvornih ribljih populacija. Zbog boljeg razumijevanja složenosti  utjecaja akvakulture na prirodne populacije, ovaj projekt će iskoristiti najnovije instrumentalne i genetske pristupe s ciljem podržavanja uzgojnih i upravljačkih aktivnosti, kao i zaštite morskog okoliša. Projekt uključuje: (i) uporabu suvremenog sustava stereoskopske kamere i multivarijatnih analizi indirektnih pokazatelja kondicije s ciljem procjene uloge uzgajališta kao ekoloških zamki divljih ribljih populacija, (ii) korištenje forenzički svojstvenih genetskih alata u procjeni genetske strukture divljih/uzgojnih riba i školjkaša , (iii) uporaba suvremenog genetski-analitičkog pristupa s ciljem određivanja porijekla uzgojnih populacija i utvrđivanja možebitnih genetskih interakcija populacija iz uzgoja s prirodnim/divljim populacijama iste vrste, a na kraju (iv) procjena utjecaja translokacije mlađi kamenica između geografski udaljenih uzgojnih lokacija na genetsku strukturu izvornih populacija kamenice u hrvatskom dijelu Jadrana.Zaključno, predloženi projekt se nadovezuje na zajednički izazov evropske zajednice  koji se očituje u poticanju razvoja održive akvakulture kroz poboljšanje konkurentnosti i ekološki prihvatljive proizvodnje. Kako su potencijalno negativni učinci akvakulture prisutni u svim zemljama EU-a, međunarodna suradnja će se biti prepoznata i implementirana tijekom provedbe projektnih zadataka. Projektni ishodi će biti dostupni svim zainteresiranim strankama odnosno istraživačima, industriji, zakonodavnim tijelima i svim potencijalnim korisnicima.]]></summary_hr><summary_en><![CDATA[Expansion of marine farming sites raised the concern that aquaculture may pose a threat to biodiversity due to detrimental impacts on wild populations and ecosystem. Ecological interactions of farm installations are reflected through  acting as new ecological niches for the local fish where also altered wild fish physiology and behaviour may occur. Another environmental risk is the potential impact of releasing farmed fish into the wild, through accidental escape or deliberate restocking. Escapes or releases of the domesticated aquaculture fish pose a potential risk of adverse effects on native fish gene pools. To better understand the complexity of aquaculture impacts on the native populations, this project will take advantage of cutting edge instrumental and genetic approaches to support aquaculture activity and management, as well as the protection of marine environment. This includes: (i) using novel stereoscopic camera system and multivariable analysis of proxy measure of fitness to asses do farms function as ecological traps for wild fish, (ii) using forensically validated genetic tools to assess genetic structure of wild/farmed fish and shellfish, (iii) using cutting edge genetic analytical approach to trace the origin of farmed fish and to monitor genetic interactions between fish from aquaculture and their wild conspecifics, and finally (iv) validation of the impact of oyster spat translocation between geographically distinct farming locations on genetic structure of native oysters populations in the Croatian part of the Adriatic Sea. Thus, this project addresses the common European challenge to develop sustainable aquaculture through improved competitiveness and environmentally-friendly production. As the potential adverse effects of aquaculture affect all EU countries, international collaboration will be implemented. The outcome of the project will be available to the researchers, the industry, policy makers and the general public.]]></summary_en></project><project>
<id>3766</id><title_hr><![CDATA[Uloga upale u razvoju zloćudnog tumora mokraćnog mjehura]]></title_hr><title_en><![CDATA[]]></title_en><user_id>5769</user_id><user_firstLast_name>Janoš  Terzić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2015-10</proposal_call><code>DOK-2015-10-6343</code><acronim><![CDATA[iBC]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Splitu, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Split School of Medicine]]></institution_en><team_members_id>22603</team_members_id><team_members_names><![CDATA[ Doktorand: Blanka Roje ]]></team_members_names><keywords_hr><![CDATA[mokraćni mjehur, rak, upala, mikrobiom, STAT3, IL-6]]></keywords_hr><keywords_en><![CDATA[bladder, cancer, inflammation, microbiome, STAT3, IL-6]]></keywords_en><summary_hr><![CDATA[Oko 20% smrtnih slučajeva od zloćudnih tumora posljedica je kronične upale. Virusne i bakterijske infekcije, infestacije parazitima, autoimunost i iritirajuće kemikalije uzrokuju upalne promjene koje stimuliraju začetak zloćudnih tumora, njihov ras i metastaziranje. Drugi istraživači i mi smo pokazali da su ključne molekularne poveznice između kronične upale i zloćudnih tumora citokin IL-6 i transkripcijski čimbenik STAT3. Postaje sve očitije da i mikrobni sastav pojedinog tkiva ima važnu ulogu u razvoju kronične upale i zloćudnih tumora. Uloga upale u patogenezi zloćudnih tumora mokraćnog mjehura (TMM) slabo je proučena iako upala izazvana sa Schistosoma haematobium potiče razvoj TMM, dok se upala uzrokovana s BCG uspješno koristi za njegovo liječenje.Za pročavanje upale u razvoju TMM koristiti ćemo najmodernije mišje modele (tzv. knock-out miševe) koijma će tumori biti inicirati s BBN-om. Analizirati ćemo: (1) ulogu IL-6 i (2) ulogu STAT3 u razvoju TMM kao i (3) terapijski potencijal STAT3 inhibitora. Nadalje planiramo (4) proučavati važnosti mikrobioma u nastanku TMM koristeći mišji model te bolesti uz upotrebu antibiotika koji će promijeniti sastav mikrobioma. Proučavajući (5) mikrobiomski sastav urina osoba s TMM i zdravih jedinki pokušati ćemo povezati određene mikrobe s TMM. Projekt proučava temeljne odlike zloćudnih tumora mokraćnog mjehura pa ukoliko se pokaže da smanjivanje aktivnosti STAT3 usporava razvoj TMM naši rezultati mogu potaknuti stvaranje novih lijekova (inhibitora STAT3) za TMM. Rezultati proučavanja mikrobioma mogu dovesti do novih preventivinih mjera (razvoja cjepiva ili upotrebe antibiotika). Kako je TMM sedmi tumor po učestalosti predloženi projekt je od velikog medicinskog, socijalnog i ekonomskog značaja. Članovi projektnog tima su iskusni istraživači su kao ključni znanstvenici objavljivali otkrića u najboljim časopisima poput Cancer Cell i Nature Genetics, što jamči uspješnu realizaciju projekta. ]]></summary_hr><summary_en><![CDATA[Around 20% of cancer deaths are a consequence of chronic inflammation. Viral and bacterial infections, parasitic infestation, autoimmunity or chemical irritants cause inflammatory changes that stimulate cancer initiation, promotion and metastasis. We and others have shown that main molecular links between inflammation and cancer are cytokine IL-6 and its transcription factor STAT3. It is becoming obvious that microbiome composition of particular niche is important element of inflammation and cancer development. The role of inflammation in urinary bladder cancer (BC) pathogenesis is poorly understood although chronic inflammation caused by Schistosoma haematobioum has pro-tumorigenic effect while acute inflammation caused by BCG is successfully used as a therapy for BC. To investigate the role of inflammation in BC development we will use BBN induced BC mice models and will study: (1) the role of IL-6 (by using IL-6 KO mice); (2) the role of STAT3 by assessing its targeted deletion in mice urothelium and (3) therapeutic potential of STAT3 inhibitor. Additionally, we plan to (4) test importance of microbiome in BC development by using mice BC model and antibiotic treatment to manipulate bladder microbiome composition and to (5) analyze human bladder cancer microbiome, in order to associate BC with specific microbiota.This project addresses fundamental questions of bladder cancerogensis. If altering STAT3 activity has inhibitory effect on BC development that finding can lead to new therapies (use of STAT3 inhibitors) for established BC. Findings generated by the microbiome analysis can lead to novel preventive measures (microbiota manipulation by antibiotics or vaccination). Team members are experienced scientist with publications in Cancer Cell and Nature Genetics which is securing successful realization of the project. Because BC is the seventh most common malignancy, proposed project is of great medical, social and economic importance.]]></summary_en></project><project>
<id>3768</id><title_hr><![CDATA[Europska bioetika na djelu]]></title_hr><title_en><![CDATA[]]></title_en><user_id>5129</user_id><user_firstLast_name>Iva Rinčić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2015-10</proposal_call><code>DOK-2015-10-3822</code><acronim><![CDATA[EuroBioAct]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Filozofija, </scie_field_hr><scie_field_en>Philosophy, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Medicine]]></institution_en><team_members_id>21391</team_members_id><team_members_names><![CDATA[ Doktorand: Maja Miloš ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[Europe, integrative bioethics, Fritz Jahr, ecology, environment, Northern Adriatic]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[The „European Bioethics in Action (EuroBioAct)” project primarily aims at:	1. completing theoretical basis for the „new European bioethics“ (by rounding-up 	research on Fritz Jahr, Ignaz Bregenzer, and other thinkers and conceiving a 	common platform with integrated ideas of modern environment science and 	ethics) and	2. applying that theoretical basis in practice (by compiling a list of „bioethical 	standards“ for settlements, containing concrete general and specific norms for 	preservation and improvement of local eco-systems – i.e., human health, animal 	and plant welfare, etc.).In the first phase of the project realisation, the participants would continue with the broadening and deepening of the theoretical basis of the „new European bioethics“ primarily by completing the research of the life and work of Fritz Jahr and his most important models (Ignaz Bregenzer and others). In the second phase of the project, three focused workshops would be organised determining the status of the general and special ecological needs for the three local communities (Plomin, Bakar, and Mali Lošinj) from the Northern Adriatic region. The three communities selected to host the workshops have either been recently experiencing ecological threats (Plomin – thermo-electric power plant; Bakar – cokery), or represent a highly-valuable and vulnerable natural insular pocket (Mali Lošinj – health tourism, dolphin wildlife refuge, fragrant gardens programme, etc.). Based on the theoretical background and the insights provided by the workshops, in the third phase of the project, created would be the „bioethical standards“, that is, a set of principles and measures of the correct relation of men toward their own health, animals, plants, and the eco-system in total. A „bioethical standards“ charter might improve the level of local community environmental consciousness, and provide direction lines for its sustainable development (including a potential tourism-advertising ace card).]]></summary_en></project><project>
<id>3770</id><title_hr><![CDATA[Matematičko modeliranje i numeričke simulacije procesa u tankim i poroznim sredinama]]></title_hr><title_en><![CDATA[]]></title_en><user_id>817</user_id><user_firstLast_name>Igor Pažanin</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2015-10</proposal_call><code>DOK-2015-10-7421</code><acronim><![CDATA[MaSiMo]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Matematika, </scie_field_hr><scie_field_en>Mathematics, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>22664</team_members_id><team_members_names><![CDATA[ Doktorand: Marko Radulović ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[Mathematical modelling,Asymptotic analysis,Numerical simulations,Fluid flow,Homogenization, Boundary layer,Lubrication,Complex fluids,Porous medium]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[We frequently deal with systems described by the differential equations coming from conservation laws that are too complicated to be solved and are of limited use in practice. In many such situations the original physical laws can be replaced by empirical laws or other approximations derived on engineering level of rigor. Mathematical point of view requires justification of those models to see their validity, applicability and accuracy. That can be achieved theoretically by investigating the deviation from the original model, or numerically by comparing simulations with experimental data. Each approach, has its advantages and disadvantages and are, frequently, complementary. In the frame of MaSiMo project we will consider fluid flow through thin domains like pipes and fractures, as well as low permeability domains as porous media.The fluids are either Newtonian or micropolar, monophase or multiphase.  Physical processes in those fluids are convective, diffusive, dispersive or conductive, isothermal  or nonisothermal. Theoretical analysis is based on a priori estimates for governing differential equations, different notions of convergence and compactness. In particular asymptotic analysis and homogenization will be used.  For derivation of a priori estimates a powerful tool is the entropy dissipation method that is considered in this project in the context of nonlinear diffusion and population dynamics problems with a perspective of extension to other considered models. Proposed research is connected to many engineering disciplines, such as mechanical and petroleum engineering, hydrogeology etc. Expected results could improve engineering practice. In Croatian mathematical community  there is a significant  research in this field with several trained scientists. However,  they are dispersed in smaller groups. One of the aims of this project is formation of larger research group with focused scientific interests more competitive in a search for European grants.  ]]></summary_en></project><project>
<id>3771</id><title_hr><![CDATA[A panEuropean framework for strengthening Critical Infrastructure resilience to Climate Change ]]></title_hr><title_en><![CDATA[]]></title_en><user_id>18910</user_id><user_firstLast_name>Kristian Horvath</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2015-10</proposal_call><code>DOK-2015-10-3960</code><acronim><![CDATA[]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Geofizika, </scie_field_hr><scie_field_en>Geophysics, </scie_field_en><institution_hr><![CDATA[Ništa od navedenog]]></institution_hr><institution_en><![CDATA[Nothing from this list]]></institution_en><team_members_id>25087</team_members_id><team_members_names><![CDATA[ Doktorand: Sarah Ivušić ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>3773</id><title_hr><![CDATA[Oscilatorna dinamika citoskeleta]]></title_hr><title_en><![CDATA[]]></title_en><user_id>11207</user_id><user_firstLast_name>Iva Tolić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2015-10</proposal_call><code>DOK-2015-10-4389</code><acronim><![CDATA[OSCITON]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Biologija, </scie_field_hr><scie_field_en>Biology, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>21341</team_members_id><team_members_names><![CDATA[ Doktorand: Mihaela Jagrić ]]></team_members_names><keywords_hr><![CDATA[citoskelet, mikrotubuli, motorni proteini, diobeno vreteno, stanično kretanje, Rho GTPaze, mikroskopija, teorijsko modeliranje]]></keywords_hr><keywords_en><![CDATA[cytoskeleton, microtubules, motor proteins, mitotic spindle, cell migration, Rho GTPases, microscopy, theoretical modeling]]></keywords_en><summary_hr><![CDATA[Oscilacije u citoskeletu važne su za biologiju stanice kao sredstvo prostorne i vremenske regulacije stanične organizacije, diobe stanica i njihove pokretljivosti. U projektu OSCITON istraživat ćemo dva oscilatorna procesa. Kao prvo, proučavat ćemo mehanizam oscilacija kinetohora koje pokreću mikrotubuli tijekom mitoze, te utjecaj kinezina-8 na taj proces. Te oscilacije stvaraju sile napetosti između sestrinskih kinetohora, bez kojih stanica ne može proći kontrolnu točku u metafazi. Oscilacije ćemo proučavati uz pomoć naprednih tehnika svjetlosne mikroskopije u HeLa stanicama u kojima ćemo eksprimirati tubulin-GFP i kinetohorni protein mRFP-Cenp-B, te smanjiti ili pojačati ekspresiju kinezina-8. Da bismo proučavali sile koje djeluju na kinetohore, promijenit ćemo ravnotežu sila laserskom mikrodisekcijom mikrotubula vezanih na kinetohore. Paralelno s eksperimentima razvit ćemo teorijski model, koji će omogućiti interpretaciju utjecaja kinezina-8 na oscilacije. Kao drugo, proučavat ćemo oscilatornu repolarizaciju stanica Dictyostelium tijekom njihovog nasumičnog gibanja. Pretpostavljamo da kompeticija efektorskih kompleksa DGAP1/korteksilin i Scar/Wave za zajednički aktivator Rac1 igra središnju ulogu u repolarizaciji. Kako bismo testirali ovu hipotezu, koristit ćemo novu fluorescentnu sondu za aktivni Rac1, stanice s poremećenom ravnotežom efektorskih kompleksa, te stanice sa reduciranom funkcionalnošću proteina Rac1. Eksperimentalno i teorijski ćemo proučavati dinamiku Rac1, njegovih efektora, te F-aktina u stanicama divljeg tipa i mutiranih sojeva. Ovaj će interdisciplinarni projekt omogućiti optimalno korištenje resursa i okupiti znanstvenike s iskustvom u širokom rasponu disciplina od molekularne i stanične biologije, biokemije, mikroskopije do teorijske biofizike. Udruživanjem svih istraživača iz područja dinamike citoskeleta u Hrvatskoj okupit ćemo tim koji će igrati važnu ulogu u tom području istraživanja na međunarodnoj razini.]]></summary_hr><summary_en><![CDATA[Oscillations in the cytoskeleton are of general importance in cell biology as a means of spatial and temporal regulation of the cellular organization, cell division and motility. The project OSCITON focuses on two oscillatory processes. First, we will investigate the mechanism of microtubule-driven kinetochore oscillations during mitosis, and the role of kinesin-8 motors in this process. These oscillations generate tension between sister kinetochores, which is required to pass the spindle checkpoint. We will use HeLa cells expressing tubulin-GFP and mRFP-CENP-B, a kinetochore protein, in combination with advanced light microscopy and depletion or overexpression of kinesin-8 motors. To study the forces acting on kinetochores, we will perturb the force balance by performing laser microsurgery of the microtubules attached to kinetochores. The experiments will be accompanied by the development of a theoretical model, which will allow us to explore the role of kinesin-8 in the oscillations. Second, we will study the oscillatory repolarization of Dictyostelium cells during random migration. We propose that the competition of DGAP1/cortexillin and SCAR/Wave complexes for the common activator Rac1 plays a central role in this process. To test this hypothesis, we will use a novel fluorescent probe for active Rac1 GTPases, generate cells with disturbed balance of Rac1 effectors, and cells deficient in functional Rac1. Dynamics of the probes for Rac1, its effectors, and F-actin will be studied experimentally in live cells and theoretically. This interdisciplinary project is designed to optimize the use of resources and bring together researchers with the expertise in a range of disciplines, including molecular and cellular biology, biochemistry, microscopy, and theoretical biophysics. Through joining forces of all investigators of the cytoskeletal dynamics in Croatia, we intend to assemble a team that will play a prominent role in this field of research internationally.]]></summary_en></project><project>
<id>3775</id><title_hr><![CDATA[Električko nabijanje međupovršina na granici čvrsta faza/vodena otopina elektrolita]]></title_hr><title_en><![CDATA[]]></title_en><user_id>244</user_id><user_firstLast_name>Tajana Preočanin</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2015-10</proposal_call><code>DOK-2015-10-6294</code><acronim><![CDATA[SAQUINT]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, </scie_field_hr><scie_field_en>Chemistry, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>22756</team_members_id><team_members_names><![CDATA[ Doktorand: Antun Barisic ]]></team_members_names><keywords_hr><![CDATA[električni međupovršinski sloj, površinske reakcije, površinski potencijal, metalni oksidi, polielektroliti, višeslojevi, kompleksiranje, nanočestice ]]></keywords_hr><keywords_en><![CDATA[electrical interfatial layer, surface reaction, surface potential, metal oxide, polyelectrolyites,multilayers, complexation, nanoparticles]]></keywords_en><summary_hr><![CDATA[Cilj je predloženog projekta istražiti procese koji se zbivaju na međupovršini čvrsta tvar/tekućina u svrhu boljeg razumijevanja interakcije površine mineralnih faza s molekulama vode, otopljenim ionima i složenim makromolekulama. Nove eksperimentalne metode omogućavaju karakterizaciju pojedinih kristalnih ploha te će se ispitati utjecaj strukture površine na nastajanje električkog međupovršinskog sloja. Za određivanje površinskog potencijala na 0-plohi pojedinih kristalnih ploha koristit će se monokristalne elektrode koje su po prvi put konstruirane u našem laboratoriju. Naime, upravo površinski potencijal na 0-plohi definira broj i vrstu površinskih specija na određenoj plohi, a time i ravnotežno stanje. Kombiniranjem podataka dobivenim mjerenjem površinskog potencijala na 0-plohi i elektrokinetičkog potencijala nastojat će se objasniti ravnotežni procesi koji se zbivaju na granici faza. Zanimljivu klasu površinskih reakcija čine procesi uzastopne naizmjenične adsorpcije polielektrolita suprotnog naboja na okside metala i polumetala. Navedeni procesi bit će istraženi u sklopu predloženog projekta. Dobiveni rezultati će se usporediti s rezultatima kompleksiranja polielektrolita u otopini. Naglasak u istraživanju bit će na specifičnom utjecaju protuiona na reakcije dvaju suprotno nabijenih polielektrolita. U konačnici rezultati dobiveni za pojedine plohe će se primijeniti na koloidne i nano čestice čija se površina sastoji od različitih kristalnih ploha. Interes za istraživanjem spomenutih nanostruktura i polielektrolita povezan je sa brojnim mogućnostima njihove primjene u industriji, odnosno razumijevanju uloge prirodnih polielektrolita i proteina u biološkim procesima. U svrhu izvođenja projekta koristit će se različite eksperimentalne metode, a za bolje razumijevanje procesa koje se zbivaju na međupovršinama i dobivanja kvantitativnog opisa specijacije svih vrsta koje sudjeluju u površinskim reakcijama, bit će razvijeni i odgovarajući teorijski modeli.]]></summary_hr><summary_en><![CDATA[In order to contribute to the understanding of basic interactions between the mineral phases and water molecules, ions and macromolecules we propose the investigations of processes at solid/liquid interfaces. Particular attention will be paid on a role of water, simple counterions and surface structure in formation of electrical interfacial layer. The single crystal electrode, device developed and constructed recently in our laboratory, will be used for determination of inner surface potential of specific crystal planes. Inner surface potential affects directly the state of ionic species bound to defined surface plane and is thus essential parameter governing interfacial equilibrium. The role of interfacial water in interfacial equilibrium will be analyzed by considering its behavior at inert surfaces but also at metal oxide surfaces. Finally, the results obtained for the particular crystal planes will be applied for colloids and nanoparticles exhibiting different crystal planes to the liquid medium. A special case of interfaces are polyelectrolytes at the metal oxide surface. Therefore, such interfaces and their correlation with the behaviour of polyelectrolytes in solution will be also extensively studied in the frame of the proposed project. The reason lies in fundamental interest to understand their properties in relation with the role of natural polyelectrolytes and proteins in biological processes, as well as in industrial applications. The latter are not limited to polyelectrolytes in solution, but include also the polyelectrolyte (or interpolyelectrolyte) complexes and multilayers. The formation of multilayers of polyelectrolytes at solid surfaces, as well as interpolyelectrolyte interactions in solution, will be examined. Special emphasis will be given on specific ionic effects. Predominantly the experimental methods will be applied, and theoretical tools will be developed in order to better understand behavior, reactivity and equilibrium at interfaces.]]></summary_en></project><project>
<id>3776</id><title_hr><![CDATA[SenseHive: Dinamički modeli za postepenu izgradnju leksičko-semantičkih resursa potpomognuti radom mnoštva]]></title_hr><title_en><![CDATA[]]></title_en><user_id>6211</user_id><user_firstLast_name>Jan Šnajder</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2015-10</proposal_call><code>DOK-2015-10-7301</code><acronim><![CDATA[SenseHive]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Računarstvo, </scie_field_hr><scie_field_en>Computer sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id>18931</team_members_id><team_members_names><![CDATA[ Doktorand: Domagoj Alagić ]]></team_members_names><keywords_hr><![CDATA[Natural language processing, language technologies, lexical semantics, semantic resources, word sense disambiguation, Croatian language]]></keywords_hr><keywords_en><![CDATA[Obrada prirodnog jezika, jezične tehnologije, leksička semantika, semantički resursi, razrješavanje višeznačnosti, hrvatski jezik]]></keywords_en><summary_hr><![CDATA[Leksičko-semantički resursi igraju bitnu ulogu u obradi prirodnoga jezika i srodnih primjena poput pretraživanja informacija. Nažalost, njihova je  izgradnja izuzetno skupa te je rijetko vođena praktičnim potrebama, što kod jezika sa slabije razvijenim resursima predstavlja naročit problem. Moguće rješenje jest izgradnja leksičko-semantičkih resursa potpomognuta radom mnoštva (engl. crowdsourcing). Premda se rad mnoštva pokazao izvedivim i znatno povoljnijim pristupom, još uvijek ne postoji cjelovita metodologija koja bi omogućila postepenu izgradnju vrlo velikih leksičko-semantičkih resursa. Cilj ovoga projekta jest upotpuniti ovu prazninu i istražiti računalne modele i metode za postepenu i učinkovitu izgradnju leksičko-semantičkih resursa potpomognutu radom mnoštva. Istraživanje će objediniti modele za dinamičan rad mnoštva, modele semantike temeljene na korpusu (distribucijske modele i tematske modele) te aktivno strojno učenje, te polučiti cjelovit i jezično neovisan radni okvir, tzv. SenseHive. SenseHive objedinjuje prilagodiv prikaz značenja i leksičko-semantičkih veza riječi temeljen na grafovima (SenseGraph) i postupke za njegovu postepenu izgradnju. Značenja riječi dinamički se razdjeljuju i stapaju na temelju analize ljudskih ocjena dobivenih nad podatcima ekstrahiranima iz korpusa. U prvoj fazi projekta izgradit ćemo prototip i upotrijebiti ga za ciljane eksperimente na podatcima na hrvatskom, slovenskom i engleskom jeziku s ciljem odgovaranja na relevantna istraživačka pitanja. Kao dokaz koncepta, u drugoj ćemo fazi primijeniti SenseHive za izgradnju leksičko-semantičkog resursa za hrvatski jezik umjerene veličine, proširivanjem i obogaćivanjem postojećih leksičko-semantičkih resursa. Predloženo će istraživanje unaprijediti stanje znanosti u području računalne semantike i poluatomatske izgradnje jezičnih resursa te rezultirati konkretnim leksičko-semantičkim resursom za hrvatski jezik od velike praktične vrijednosti.]]></summary_hr><summary_en><![CDATA[Lexico-semantic resources play an essential role in natural language processing and related applications such as information retrieval. Unfortunately, their construction is extremely costly and rarely guided by practical considerations, posing a problem especially for less-resourced languages. One possible solution is to rely on crowdsourcing of lexico-semantic resources. Although crowdsourcing has proven to be a viable option for reducing the overall costs, there still does not exists a comprehensive crowdsourcing methodology for incremental construction of large-scale lexico-semantic resources. This projects aims to fill this gap by investigating the computational models and methods for incremental and cost-efficient crowdsourcing of lexico-semantic resources. The research will combine dynamic crowdsourcing, corpus-based models of semantics (distributional semantics and topic models), and active machine learning methods into a comprehensible and language-independent crowdsourcing framework, the SenseHive. The SenseHive consists of a flexible, graph-based representation of senses and lexico-semantic relations (SenseGraph), coupled with an incremental construction methodology. In SenseGraph, senses are dynamically split up and merged based on the analysis of human judgments on corpus-extracted data. In the first phase, we will implement a prototype of the SenseHive framework and use it for focused evaluation experiments on Croatian, Slovene, and English data to answer the relevant research questions. As a proof of concept, in the second phase we will use SenseHive to construct a medium-sized lexico-semantic resource for Croatian by enlarging and enriching existing lexico-semantic resources. The proposed research will advance the state of the art in computational lexical semantics and semi-automated construction of linguistic resources, and yield a lexico-semantic resource for Croatian of great practical value.]]></summary_en></project><project>
<id>3777</id><title_hr><![CDATA[Esencijalni metalni ioni u proteinima iz Helicobacter pylori i modelnim spojevima - struktura i funkcija/svojstvo]]></title_hr><title_en><![CDATA[]]></title_en><user_id>946</user_id><user_firstLast_name>Ivica Đilović</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2015-10</proposal_call><code>DOK-2015-10-1123</code><acronim><![CDATA[ProtModStruct]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, </scie_field_hr><scie_field_en>Chemistry, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>20946</team_members_id><team_members_names><![CDATA[ Doktorand: Kristina Smokrović ]]></team_members_names><keywords_hr><![CDATA[essential metals, model compounds, structural characterization, H. pylori proteins, chemical synthesis]]></keywords_hr><keywords_en><![CDATA[esencijalni metali, modelni spojevi, strukturna karakterizacija, proteini iz H. pylori, kemijska sinteza]]></keywords_en><summary_hr><![CDATA[U okviru istraživanja na ovom projektu želimo strukturno karakterizirati nekoliko proteina iz Helicobacter pylori (i odrediti njihovu funkciju) kao i modelne komplekse malih molekula sa esencijalnim metalnim ionima i biološki važnim ligandima (i odrediti njihova svojstva). Prioritetni će biti metali koji se nalaze u metaloproteinima iz H. Pylori.Svjetska zdravstvena organizacija proglasila je H. Pylori karcinogenom 1. klase te je važna meta istraživanja zbog svoje patogenosti. Proteini HypA i HypB su važni za pravilnu konstrukciju metalnog centra [Ni,Fe] hidrogenaze i urease. Proteini CrdA i CrdB potrebni su za održavanje koncentracije slobodnih iona bakra u citoplazmi ispod toksične razine. Namjeravamo klonirati, eksprimirati, pročistiti i karakterizirati kompleks HypA-HypB te proteine CrdA i CrdB biofizičkim i strukturnim metodama (termalna stabilnost, cirkularni dikroizam, određivanje konstante disocijacije bakrovog iona, rentgenska difrakcija, 3D NMR). Želimo odrediti funkciju metalošaperona u unutarstaničnoj regulaciji nikla (HypA-HypB) kao i mehanizam regulacije koncentracije bakra (CrdA, CrdB).Istraživati ćemo komplekse metala (bakra, nikla, željeza i drugih esencijalnih metala) s ciljem da odredimo preferirano koordinacijsko okruženje metala s aminokiselinama i derivatima aminokiselina (N-alkiliranih, amida, peptida, peptida bogatih metioninom i drugih) te dobijemo informaciju o specifičnosti aminokiselinskog ili peptidnog pokrajnjeg lanca prema različitim metalnim ionima. Komplekse ćemo sintetizirati te ih karakterizirati termičkim i spektroskopskim metodama i rentgenskom strukturnom analizom. Konstruirat ćemo konformacije bakrovih kompleksa s aminokiselinama te optimizirati njihovu geometriju pomoću kvantno-kemijskih proračuna da bismo istražili njihove moguće ravnotežne geometrije.]]></summary_hr><summary_en><![CDATA[Within this project we will structurally characterize several proteins from Helicobacter pylori (and reveal their functions) and small molecule model complexes of essential metal ions with biologically relevant ligands (and find their properties). The priority will be the essential metals involved in H. pylori metalloproteins.The World Health Organization has declared the H. pylori a Class 1 carcinogen and it is an important target for research due to its pathological relevance. H. pylori requires several accessory proteins such as HypA and HypB for the proper construction of the [Ni,Fe] hydrogenase and urease. The resistance determinants CrdA and CrdB are required for keeping the concentration of free copper ions in the cytoplasm below toxic levels. We plan to clone, express, purify and characterize the complex HypA-HypB and proteins CrdA and  CrdB by biophysical and structural methods (thermal stability assay, circular dichroism, determination of copper ion dissociation constant, X-ray diffraction, 3D NMR). We hope to determine how the metallochaperones exert their functions in intracellular nickel delivery (HypA-HypB) and the mechanism of copper level regulation (CrdA, CrdB).The aim of the study of the model complexes (with copper, nickel, iron, zinc and other essential metal ions) is to determine how these metals template their coordination environment by amino acids and their derivatives (N-alkylated, amides, peptides, methionine-rich peptides and others) and to obtain information on the specificity of amino acid or short peptide side chains toward different metal ions. The complexes will be synthesized and structurally characterized by thermal and spectroscopic analysis and X-ray crystal structure diffraction experiments.The conformations of the copper complexes with amino acids will be constructed and the geometry optimized to study their possible equilibrium geometries by quantum chemical calculations.]]></summary_en></project><project>
<id>3779</id><title_hr><![CDATA[Neuropathology of Sleep Apnoea]]></title_hr><title_en><![CDATA[]]></title_en><user_id>12653</user_id><user_firstLast_name>Dinko Mitrečić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2015-10</proposal_call><code>DOK-2015-10-5568</code><acronim><![CDATA[]]></acronim><duration>01.11.2018 - 30.06.2022</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb School of Medicine]]></institution_en><team_members_id>25396</team_members_id><team_members_names><![CDATA[ Doktorand: Damir Lisjak ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>3781</id><title_hr><![CDATA[Istraživanje školskog vođenja iz distributivne perspektive u hrvatskim školama]]></title_hr><title_en><![CDATA[]]></title_en><user_id>4623</user_id><user_firstLast_name>Branko Rafajac</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2015-10</proposal_call><code>DOK-2015-10-4007</code><acronim><![CDATA[IScLEAD]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Pedagogija, </scie_field_hr><scie_field_en>Pedagogy, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Filozofski fakultet u Rijeci]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Humanities and Social Sciences]]></institution_en><team_members_id>23308</team_members_id><team_members_names><![CDATA[ Doktorand: Adriana Ažić Bastalić ]]></team_members_names><keywords_hr><![CDATA[upravljanje obrazovnim sustavom, distributivno školsko vođenje, učinkovitost škola, jedinice lokalne samouprave, ravnatelji, učitelji, škole]]></keywords_hr><keywords_en><![CDATA[governance of educational system, distributive school leadership, school effectiveness, local educational authorities, school principals, teachers, sc]]></keywords_en><summary_hr><![CDATA[Predloženo istraživanje fokusira se na fenomen školskog vođenja koji se određuje kao jedan od najznačajnijih faktora uspješnosti škola odnosno postignuća učenika, a u širem kontekstu i uspješnosti odnosno održivosti obrazovnih reformi. Glavni cilj istraživanja je identificirati obilježja prakse školskog vođenja u hrvatskim školama s posebnim naglaskom na indikatore individualnog naspram distributivnog vođenja te iznalaženje onih obilježja školskog vođenja koja su povezana s učinkovitosti škola. Glavni cilj istraživanja realizirat će se kroz sljedeće specifične zadatke: 1) Ispitati obilježja školskog vođenja s posebnim naglaskom na ulogu i vrstu participacije i interakcija pojedinih dionika u aktivnostima vođenja (ravnatelja, školskog odbora, učiteljskog/nastavničkog vijeća, stručne službe, učitelja, roditelja, učenika, predstavnika zajednice i lokalne samouprave) i njihove povezanosti s indikatorima školskog uspjeha; 2) Ispitati različita obilježja upravljanja hrvatskim obrazovnim sustavom iz perspektive različitih dionika (komunikacija i suradnja između autoriteta na državnoj razini, razini lokalne samouprave i razini škole; zadovoljstvo načinom funkcioniranja obrazovnog sustava) i njihov efekt na praksu školskog vođenja. Rezultati prijašnjih istraživanja i preliminarni izvještaji povezani s hrvatskim obrazovnim sustavom ukazuju na važnost osnaživanja karakteristika distributivnog školskog vođenja s naglaskom na osnaživanje kapaciteta učitelja kao aktivnih sudionika u procesu donošenja odluka koje se odnose na obrazovanje. ]]></summary_hr><summary_en><![CDATA[The proposed research focuses on the phenomenon of school leadership which is seen as one of the most important success factors of school and student achievement. In the broader context, it is seen as a success i.e. sustainability factor of education reforms. The main aim of this research is to identify the characteristics of the school leadership practice in Croatian schools with the special emphasize on indicators of both solo and distributive leadership and finding those features that are associated with the school and student achievement. The main aim will be elaborated through the following specific tasks: 1) examining the characteristics of school leadership with special emphasis on the role of participation and interaction of individual stakeholders in the activities of leadership (school principals, school boards, school councils, professional services, teachers, parents, students, community representatives and local government) and their association with indicators of school success; 2) examining various features of education system governance from the perspectives of different stakeholders (communication and collaboration between state level, local governments and school level authorities; overall satisfaction with the education system governance) and their effects on the school leadership practice. Results of the previous studies and preliminary review related to Croatian education system point to the importance of strengthening the characteristics of the distributed school leadership with special emphasis on strengthening the capacity of teachers as active participants in making key decisions related to the matters of education.]]></summary_en></project><project>
<id>3782</id><title_hr><![CDATA[Diracovi operatori i teorija reprezentacija]]></title_hr><title_en><![CDATA[]]></title_en><user_id>5573</user_id><user_firstLast_name>Pavle Pandzic</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2015-10</proposal_call><code>DOK-2015-10-5710</code><acronim><![CDATA[representations]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Matematika, </scie_field_hr><scie_field_en>Mathematics, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>22605</team_members_id><team_members_names><![CDATA[ Doktorand: Josip Grgurić ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[Harish-Chandra modules, Dirac operators, cohomology, Dirac induction, branching problems]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Dirac operators were introduced into representation theory by Parthasarathy in the 1970s. In the 1990s, Vogan conjectured a strengthening of Parthasarathy&#39;s Dirac inequality, which relates the cohomology of the Dirac operator to the infinitesimal character of the representation. This conjecture was proved in a joint paper with Huang . In further research, in part joint with various collaborators (Barbasch, Huang, Kang, Mehdi, Protsak, Renard, Somberg, Zhu) , we related Dirac cohomology to other kinds of cohomology, calculated it explicitly for many interesting representations, and studied algebraic Dirac induction, a construction of representations with given Dirac cohomology. The proposed project will continue this research in several directions: 1) the study of representations obtained by Dirac induction, in particular the discrete series representations (doctoral research of Ana Prlić). 2) applying Dirac cohomology to problems of restricting representations. Some instances of this have been studied with Huang-Zhu and with Somberg. 3) trying to strengthen the Dirac inequality, which should have implications for the study of unitary representations. Some preliminary work on  the convex hull conjecture of Salamanca-Vogan has been done with Renard. 4) calculating the Dirac cohomology of  unipotent representations. Some cases of this have been obtained jointly with Barbasch. This could lead to better understanding of characters of unipotent representations, which is related to the Assem conjecture. It would also be interesting to calculate the Dirac cohomology of unitary highest weight modules. Other topics we plan to cover include studying translation principle for Dirac index (joint with Mehdi and Vogan); studying n-cohomology and BGG resolutions using Penrose transforms (joint with Soucek);  studying some abstract homotopy and homology theory, with applications to tensor categories of representations (doctoral research of Matija Bašić).]]></summary_en></project><project>
<id>3784</id><title_hr><![CDATA[Sinteza, strukturna analiza i biološka evaluacija peptidomimetika i glikokonjugata ]]></title_hr><title_en><![CDATA[]]></title_en><user_id>569</user_id><user_firstLast_name>Srđanka Tomić-Pisarović</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2015-10</proposal_call><code>DOK-2015-10-7312</code><acronim><![CDATA[PEPTGLYCOSAR]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, </scie_field_hr><scie_field_en>Chemistry, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>22776</team_members_id><team_members_names><![CDATA[ Doktorand: Nora Tir ]]></team_members_names><keywords_hr><![CDATA[peptidomimetici, peptidoglikan, feroceni, manokonjugati, bioaktivnost]]></keywords_hr><keywords_en><![CDATA[peptidomimetics, peptidoglycan, ferrocenes, mannoconjugates, bioactivity]]></keywords_en><summary_hr><![CDATA[Osnovni cilj ovog projektnog prijedloga je sinteza, strukturna analiza i biološka evaluacija dvije vrste novih peptidomimetika: (i) peptidnih spojeva peptidoglikanskog tipa s imunomodulacijskim djelovanjem, u svrhu ispitivanja njihove interakcije sa specifičnim receptorima te (ii) peptidnih konjugata s ferocenom, s kiralno organiziranim strukturama ostvarenima povezivanjem intramolekulskim vodikovim vezama, a koje su preduvjet za stvaranje 3D struktura i funkcioniranje bioloških sustava. Također će se pripraviti glikokonjugati tih spojeva te će se proučavati njihova biološka svojstva. Naglasak će biti na manokonjugatima obzirom da je to jedan od monosaharida kojeg prepoznaju specifični receptori na površini stanica. Manozilirani peptidoglikanski fragmenti s adamantanskom podstrukturom ugrađivati će se u liposome na način da manozne jedinice budu na njihovoj površini kako bi bile dostupne za manozne receptore na stanicama imunološkog sustava. Sljedeći je cilj ovog projektnog prijedloga sinteza peptidoglikanskih fragmenata s ugrađenom ferocenskom podjedinicom te pručavanje konformacija tih molekula. Ferocenski alfa-manozidi ispitat će se pomoću testa inhibicije hemaglutinacije kao potencijalni inhibitori infekcije koju uzrokuje Escerichia coli. Ova istraživanja proširit će se i na alfa-manozide heterocikličkih spojeva kao što su 3-hidroksipiridin-4-oni, imidazolijevi i benzimidazolijevi derivati, koji su česti sastavni dijelovi spojeva sa širokim spektrom bioloških djelovanja. Biološka evaluacija svih pripravljenih spojeva ovog projektnog prijedloga provoditi će se, jednim svojim dijelom, u suradničkim institucijama u svrhu korelacije struktura derivata s njihovom biološkom aktivnošću. Studije molekulskog modeliranja koristit će se za predviđanje strukturnih promjena u svrhu poboljšanja aktivnosti.]]></summary_hr><summary_en><![CDATA[In this project proposal the main goal is the synthesis, structural characterization and biological evaluation of novel peptidomimetics of two types: (i) peptidoglycan derived peptides possessing immunomodulating activity in order to study their interactions with specific receptors and (ii) ferrocene-peptide conjugates which comprise an efficient bioorganometallic constraint designed to induce chirally organized structures through intramolecular hydrogen bonding as a prerequisite for 3D structure formation and function of biological systems. Glycoconjugates of these compounds will be prepared and their biological properties studied with emphasis on mannoconjugates since mannose is one of the carbohydrates recognized by receptors on cell surfaces. Mannosylated peptidoglycan fragments with the adamantane moiety will be incorporated into liposomes with mannose exposed at the surface serving in targeting mannose receptors on immune cells. Furthermore, peptidoglycan fragments will be modified with the ferrocenyl moiety and their conformational properties studied. Alpha-mannoside derivatives of these compounds will be also investigated as possible inhibitors of infections caused by Escerichia coli using the hemagglutination test. These studies will be extended to alpha-mannoside derivatives of heterocyclic compounds such as 3-hydroxypyridine-4-ones, imidazoles and benzimidazoles which are common parts of substances with a broad spectrum of biological activities. Screening and evaluation of biological properties of all compounds to be synthesized will be performed, partly in collaborative institutions. Molecular modelling will be used in predicting structural changes leading to improved biological activities. ]]></summary_en></project><project>
<id>3788</id><title_hr><![CDATA[Definiranje mogućnosti uporabe mini dentalnih implantata (MDI) i njihovi rezultati u in vitro i u kliničkim prospektivnim istraživanjima]]></title_hr><title_en><![CDATA[]]></title_en><user_id>7709</user_id><user_firstLast_name>Asja Čelebić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2015-10</proposal_call><code>DOK-2015-10-8878</code><acronim><![CDATA[Mini implantati/ MDI]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Dentalna medicina, </scie_field_hr><scie_field_en>Dental medicine, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu]]></institution_hr><institution_en><![CDATA[University of Zagreb]]></institution_en><team_members_id>22616</team_members_id><team_members_names><![CDATA[ Doktorand: Ines Kovačić ]]></team_members_names><keywords_hr><![CDATA[Mini dentalni implantati, standardni implantati, mehanička teastiranja na modelima, klinička prospektivna istraživanja, određivanje indikacija za MDI]]></keywords_hr><keywords_en><![CDATA[Mini dental implants, standard implants, mechanical testing on models, clinical prospective studies, MDI indications]]></keywords_en><summary_hr><![CDATA[Mini dentalni implantati (MDI) su jednokomadni uski implantati za privremenu (ortodoncija, privremeni mostovi) ili za dugoročnu kliničku upotrebu. Prednosti MDI za trajnu kliničku primjenu su u njihovoj niskoj cijeni i jednostavnoj proceduri. Iako na dentalnom tržištu postoje već 10 godina, dokazi o budućim kliničkim istraživanjima za definiranje njihovih kliničkih protokola i njihovom dugoročnom ishodu nedostaju. Stoga planiramo istraživati njihova mehanička svojstva na modelima s obzirom na moment sile prilikom insercije, mogućnost loma prilikom cikličkih opterećenja ili  opterećenja prilikom naprezanja. Situacija slična stanju u ustima  će se simulirati pomoću različitih kosti tvrdoće modela (guste vs kosti niske gustoće) s 2 vrste sluznice  različite širine, te insercijom  1, 2, 3 ili 4 MDI različite širine i dužine za retenciju pokrovne proteze. 3 D printevi služiti će da bi se razvili modeli na kojima će se testirati. Nadalje, buduće kliničke studije koje će se temeljiti na pacijentovoj procjeni ishoda terapije (pomoću psihometrijski odobrenih upitnika) i kliničkih parametara (preživljavanje implantata, komplikacije, razina kosti oko implantata, resorpcija na stražnjim bezubim dijelovima ispod baze proteze, kortikalni indeksi na donjem rubu mandibule, vrijednosti gonion i antegonion udubina, gustoća kostiju u područjima interesa koji će biti izraženi u debljini stepwedga, mjerenje plak, gingiva i kalkulus indeksa, ISQ vrijednosti) će također biti predmetom istraživanja. Podaci će se upoređivati sa onima dobivenim nakon jedne i 3 godine.  Rezulati dobiveni temeljem pacijentove procjene usporediti će se s kliničkim dobivenim parametrima. Nadalje, rezultati dobiveni s obzirom na kliničke parametre kod pacijenata sa MDI (kvaliteta kostiju, količina, gustoća) će se uspoređivati sa podacima kod pacijenata sa potpunim protezama, kod pacijenata sa pokrovnim proteze na 2-standardna implantata te kod  osoba s prirodnim zubala. Također će se proučavati različite mogućnosti retencije proteza (mehanizmi).]]></summary_hr><summary_en><![CDATA[Mini dental implants (MDIs) are one piece slim implants for temporary (orthodontics, temporary bridges) or for a long term clinical use. Advantages of MDIs for a permanent clinical use are their low cost and simple procedures. Although they exist at the dental market for 10 years, evidence based prospective clinical studies for definition of their clinical protocols and long term outcomes are missing. Therefore we plan to study first their mechanical properties on models considering placement torque, fracture torque, possibility of fracture upon cycling loads or strain loads. A situation similar to real one will be simulated by using different bone hardness models (dense vs, low density bone) with 2 different oral mucosa widths, and with insertion of 1, 2, 3 or 4 MDIs of different width and length for overdenture retention. 3D prints will be helpful in model development. Further, prospective clinical studies based on both, patient based outcomes (assessed by psychometrically approved questionnaires) and clinical parameters (implant survival, any complications, bone level adjecent to implants, bone resorption at posterior edentulous sites under a denture base, cortical indices changes at the low border of the mandible, gonion angle and antegonion pitch values, bone density in the region of interest expressed as equvivalents of actual Cu stepwedge thickness attached during exposure, plaque, gingival and calculus indices, ISQ values) will be performed. Baseline data will be compared to a 1-year and 3-year outcomes. Patient based outcomes will be compared with clinical data. Results considering clinical parameters (bone quality, quantity, density) will be compared to similar data in complete denture wearers, in overdenture patients with dentures retained by 2-standard size implants and in individuals with natural dentition. Different denture retention options (mechanisms) will also be studied.]]></summary_en></project><project>
<id>3790</id><title_hr><![CDATA[TERAPIJSKI POTENCIJAL ORALNE GALAKTOZE U EKSPERIMENTALNOJ ALZHEIMEROVOJ BOLESTI]]></title_hr><title_en><![CDATA[]]></title_en><user_id>1198</user_id><user_firstLast_name>Melita Šalković-Petrišić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2015-10</proposal_call><code>DOK-2015-10-5041</code><acronim><![CDATA[GALAD]]></acronim><duration>16.01.2017 - 27.02.2022</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb School of Medicine]]></institution_en><team_members_id>22452</team_members_id><team_members_names><![CDATA[ Doktorand: Ana Babić ]]></team_members_names><keywords_hr><![CDATA[oralna galaktoza, streptozotocin, transgenični Tg2576 miševi, Alzheimerova bolest, glukagonu sličan peptid-1]]></keywords_hr><keywords_en><![CDATA[oral galactose, streptozotocin, transgenic Tg2576 mice, Alzheimer&#39;s disease, glucagone-like peptide-1]]></keywords_en><summary_hr><![CDATA[Cilj istraživanje je ispitati novi terapijski pristup Alzheimerovoj bolesti (AB), kao najčešćem obliku demencije. Porastom dokaza o inzulinskoj rezistenciji u mozgu (IRM) i cerebralnom metaboličkom poremećaju kao medijatorima sporadične AB (sAB), normaliziranje inzulinske signalizacije i posljedičnih poremećaja u mozgu postali su novi ciljevi u liječenja AB. Poseban doprinos istraživanja je karakterizacija terapijskog potencijala oralno primijenjene galaktoze u životinjskim modelima koji oponašaju sAB i familijarnu AB. Model za sAB su štakori s intracerebroventrikularnom primjenom streptozotocina (STZ-icv model) koja inducira nastajanje IRM i vremenom pojavu mnogih sAB-u sličnih obilježja. Model za familijarnu AB su transgenični Tg2576 miševi koji vremenom pokazuju neke od znakova IRM. Galaktoza je alternativni izvor energije; ulazi u stanice inzulin-neovisnim nosačem za glukozu GLUT3 i metabolizira se u glukozu. Nedavni rad glavnog ispitivača pokazao je da oralna galaktoza sprečava nastajanje kognitivnih deficita u štakorskom STZ-icv modelu. Ovo će istraživanja ispitati sprečava li ih u Tg2576 miševa te ublažava li već nastale kognitivne deficite u oba modela. Inovativni aspekt projekta je u rasvjetljavanju učinaka posredovanih oralnom galaktozom; poboljšanja cerebralnog unosa glukoze i stimulacije sekrecije glukagonu-sličnog peptida-1 (GLP-1) te njihove korelacije s kognitivnim poboljšanjem. Za utvrđivanje učinka 2-mjesečne primjene oralne galaktoze na poremećaje pamćenja koristit će se Morris Water Maze i Passive Avoidance testovi, radio-obilježenim ligandom pratit će se metabolizam glukoze u mozgu, dok će se Western blot analizom, imunohistokemijom i enzimskim imunoadsorpcijskim testom odrediti razina GLUT3/GLUT4 i inzulin-razgrađujućeg enzima, tau i amiloidna patologija u mozgu te količina galaktoze, inzulina i GLP-1 u plazmi i likvoru. Rezultati projekta generirat će nove spoznaje i omogućiti značajan uvid u novi, na nutrijentu temeljeni pristup liječenju AB.]]></summary_hr><summary_en><![CDATA[This project aims to explore a novel therapeutic strategy in Alzheimer’s disease (AD), the most common form of dementia. Owing to growing evidence of brain insulin resistance (BIR) and cerebral metabolic dysfunction being the mediators of sporadic AD (sAD), restoring of brain insulin signalling and downstream defects has recently become a new target in AD treatment research. Unique contribution of this proposal is in characterization of the therapeutic potential of oral galactose in animal models which mimic sAD and familial AD. The former is generated by streptozotocin-intracerebroventricular application (STZ-icv rat) which induces BIR and eventually develops many of sAD-like features, and the latter is transgenic Tg2576 mice which eventually show some signs of BIR. Galactose is alternative source of energy; it enters the cell via insulin-independent glucose transporter GLUT3 and is metabolized to glucose. PI’s recent publication indicates that oral galactose prevents development of cognitive deficits in STZ-icv rat model. This research will explore if it can prevent them in Tg2576 mice and ameliorate already developed cognitive deficits in both Tg2576 mice and STZ-icv rats. Innovative aspect of the proposal is elucidation of oral galactose-mediated improvement in cerebral glucose uptake and stimulation of glucagone-like peptide-1 (GLP-1) secretion, and their correlation to cognitive improvement in both models. Morris Water Maze and Passive Avoidance tests, radio-tracing of brain glucose metabolism, Western blot analysis, Enzyme-Linked Immunosorbent Assays and immunohistochemistry will be used to detect effects of 2-month oral galactose treatment on memory loss, GLUT3/GLUT4 and insulin degrading enzyme levels, tau and amyloid-ß pathology in the brain, and galactose, insulin and GLP-1 levels in blood/cerebrospinal fluid. Project results will gain new knowledge and provide significant insights into a novel nutrient-related therapeutic strategy in AD treatment.]]></summary_en></project><project>
<id>3792</id><title_hr><![CDATA[Mehanokemijska reaktivnost pod kontroliranim uvjetima temperature i atmosfere za čistu sintezu funkcionalnih materijala]]></title_hr><title_en><![CDATA[]]></title_en><user_id>625</user_id><user_firstLast_name>Ivan Halasz</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2015-10</proposal_call><code>DOK-2015-10-6424</code><acronim><![CDATA[MECHANOCONTROL]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, </scie_field_hr><scie_field_en>Chemistry, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>21253</team_members_id><team_members_names><![CDATA[ Doktorand: Stipe Lukin ]]></team_members_names><keywords_hr><![CDATA[mehanokemijska sinteza, reaktivnost u čvrstom stanju, in situ monitoring, templatiranje i adsorpcija plinova, funkcionalizacija metal-ugljik veze]]></keywords_hr><keywords_en><![CDATA[mechanochemical synthesis, solid-state reactivity , in situ monitoring, gas-templation and adsorption, functionalization of metal-carbon bond]]></keywords_en><summary_hr><![CDATA[Mehanokemijske reakcije su se nametnule u posljednje vrijeme kao brza i ekološki prihvatljiva alternativa konvencionalnoj kemijskoj sintezi u velikom broju područja, od sinteze nanomaterijala i slitina do supramolekulskih organskih materijala i koordinacijskih mreža. Područje se posebno razvilo uvođenjem novih tehnika, tekućinom potpomognutog mljevenja ili ionima- i tekućinom potpomognutog mljevenja, koji uključuju dodatak aditiva u reakcijske smjese. Unatoč velikom broju objavljenih radova, načini kontrole osnovnih reakcijskih uvjeta, poput temperature i tlaka unutar mehanokemijskog reaktora, još uvijek nisu uvedeni u standardne mehanokemijske postupke. Štoviše, znanja o utjecaju reakcijskih uvjeta i aditiva na mehanizme reakcija mljevenja su još na spekulativnom nivou.Glavni cilj predloženog projekta je istraživanje fundamentalnih aspekata mehanokemijskih reakcija pod kontroliranom tlakom i u određenom rasponu temperatura. Okolišno relevantni plinovi (poput ugljikova(IV) oksida, metana, sumporovih i dušikovih oksida) će se koristiti kao templati ili reaktanti za sintezu poroznih koordinacijskih spojeva ili organskih spojeva. Također, ispitati će se vezanje plinova na neporozne koordinacijske spojeve, te funkcionalizacija ugljikovih atoma iz organometalnih spojeva.Da bismo uspješno ostvarili ciljeve projekta, razviti ćemo mehanokemijske reaktore u kojima će biti moguće kontrolirati temperaturu i tlak. Mehanistički aspekti mehanokemijskih reakcija između plinova i krutina biti će određeni in situ tehnikama praćenja nedavno razvijenih unutar naše grupe.Iskustvo i saznanja prikupljeni implementacijom ovoga projekta će se iskoristiti za istraživanja mehanokemijske sinteze ciljanih materijala, a s krajnjim ciljem stjecanja dubljeg uvida u mehanokemijske reakcije i proširenja  potencijala za njihovu primjenu. Očekujemo da će rezultati projekta imati snažan utjecaj na korištenje reakcija u čvrstom stanju, kako u istraživačkim laboratorijima, tako i u kemijskoj industriji.]]></summary_hr><summary_en><![CDATA[Mechanochemical reactions by milling have recently emerged as excellent, rapid and cleaner alternative to conventional solution synthesis in a number of areas, from nanomaterials and alloys to supramolecular, organic materials and metal-organic frameworks. The area flourished after the introduction of new techniques, liquid-assisted grinding and ion- and liquid assisted grinding, involving additives in the reaction mixtures. Despite a growing rate of published articles, the means of controlling the basic milling reaction conditions, such as temperature and pressure in the vessel, is still not a part of standard milling procedures. Moreover, understanding of the effect of reaction conditions and additives on milling-reaction mechanisms is currently on speculative level.The main objective of this project proposal is to explore fundamental aspects of mechanochemical solid-state reactions under controlled pressure and in a range of temperatures. We will employ different gases (with special focus on environmentally relevant gases such as carbon dioxide, methane and sulfur- or nitric oxides) as reacting agents and templates for the synthesis of porous metal-organic and covalent organic frameworks, to selectively bind pollutant gases to nonporous coordination compounds or to functionalize carbon atoms in organometallic compounds. To successfully implement the objectives of this project proposal, we will develop milling vessels where the described reaction conditions can be achieved. Mechanistic aspects of gas-solid milling reactions will be studied by our novel in situ and real-time monitoring techniques.The experience and knowledge acquired by the project implementation will be applied to mechanochemical formation of target materials in order to broaden understanding and application scope of mechanochemical reactivity. The project results are expected to have a strong transformative effect on solid-state reactivity in a research laboratory as well as in chemical industry.]]></summary_en></project><project>
<id>3793</id><title_hr><![CDATA[Zelena sinteza organopaladijevih foto-osjetljivih spojeva]]></title_hr><title_en><![CDATA[]]></title_en><user_id>112</user_id><user_firstLast_name>Manda Ćurić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2015-10</proposal_call><code>DOK-2015-10-6974</code><acronim><![CDATA[GREENSENS]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, </scie_field_hr><scie_field_en>Chemistry, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>21286</team_members_id><team_members_names><![CDATA[ Doktorand: Alen Bjelopetrović ]]></team_members_names><keywords_hr><![CDATA[mehanokemija, starenje, aktivacija C-H veze, mehanizam, spektroskopija, neinvazivni kromogeni i fluorogeni kemosenzori  ]]></keywords_hr><keywords_en><![CDATA[mechanochemistry, aging, C-H bond activation, organopalladium, mechanism, spectroscopy, non-invasive chromogenic and fluorogenic chemosensors]]></keywords_en><summary_hr><![CDATA[Zelena kemija je na čelu aktualnih zbivanja raznih istraživačkih područja u kemiji. Jedan od njezinih glavnih ciljeva je razvijanje učinkovitih preparativnih metoda za različite vrste postojećih i novih kemikalija bez korištenja otapala i uz nisku potrošnju energije. Izvedivost ovog temeljnog koncepta zelene kemije bit će pokazana na sintezi organopaladijevih kompleksa te će većina sintetskih koraka u ovom projektu biti provedena reakcijama u čvrstom stanju, upotrebom metoda ubrzanog starenja i mehanokemije. Prvu mehanosintezu organopaladijevih spojeva aktivacijom C-H veze paladijevim(II) acetatom nedavno je objavila naša grupa. Valja napomenuti da je aktivacija C-H veze od iznimne važnosti u sintetskoj organskoj kemiji. U okviru ovog projekta predlažemo razvijanje i primjenu metoda u čvrstom stanju za sintezu niza ciklopaladiranih aromatskih azo spojeva. Interes za organopalladijeve komplekse s konjugiranim C=C and N=N vezama proizlazi iz njihove jake apsorpcije i emisije svijetla u području niskih energija što ih kvalificira kao dobre kandidate za biomolekulske obilježivače. U tom pogledu, njihov afinitet prema ciljanim amino kiselinama, kratkim peptidima i nukleobazama istražit će se UV-vis and fluorescentnom spektroskopijom. Shodno navedenom, dodatna korist od predloženog projekta bit će niz novih kromogenih i fluorogenih kemosenzora.Struktura produkata u čvrstom stanju odredit će se rendgenskom difrakcijom, NMR, Raman i IR spektroskopijama. Mehanizam ciklopaladacije u čvrstom stanju istražit će se u realnom vremenu in situ praćenjem reakcija Raman spektroskopijom, te u otopini UV-vis i NMR spektroskopijama uz ESI spektrometriju masa. Optička svojstva kompleksa u čvrstom stanju i otopini odredit će se UV-vis and fluoroscentnom spektroskopijom. Eksperimentalni rezultati racionalizirat će se teorijskim istraživanjima da bi se objasnila izomerija kompleksa, priroda njihovih elektronskih prijelaza te da bi se dobila dodatna potvrda za mehanizam ciklopaladacije.]]></summary_hr><summary_en><![CDATA[Green chemistry is at the forefront of current developments of various research areas in chemistry. One of its major objectives is to develop efficient solvent-free and low-energy preparative methods for various classes of existing and new chemicals. The feasibility of this green-chemistry concept will be demonstrated on the synthesis of organopalladium complexes and the majority of synthetic steps in this project will be performed in the solid state by methods of accelerated aging and mechanochemistry. The first mechanosynthesis of organopalladium compounds via C-H bond activation, which is of exceptional importance in organic synthesis, by palladium(II) acetate has been recently reported by our group.Within this project we propose to develop and implement the solid-state methods for the synthesis of a series of cyclopalladated aromatic azo compounds. Interest in such complexes with conjugated C=C and N=N bonds arises from their strong absorption and emission in the low energy region, which qualifies them as good candidates for the biomolecular labels. In this regard, their affinity to target amino acids, short peptides and nucleobases will be studied by UV-vis and fluorescence spectroscopies. Consequently, an additional benefit of this project will be a series of new chromogenic and fluorogenic chemosensors.The solid-state structures of the products will be determined by X-ray diffraction, NMR, Raman and IR spectroscopies. The cyclopalladation mechanism in the solid state will be studied by in situ monitoring of the reactions using Raman spectroscopy, and in the solution by UV-vis and NMR spectroscopies along with the ESI mass spectrometry. The optical characteristics of complexes will be evaluated by UV-vis and fluorescence spectroscopies. The experimental results will be rationalized by theoretical studies in order to explain isomerism of complexes, the nature of their electronic transitions and to obtain additional support for the cyclopalladation mechanism.]]></summary_en></project><project>
<id>3794</id><title_hr><![CDATA[Integracijski procesi većine i manjine u etnički mješovitim zajednicama: uloga međuetničkog kontakta, percipirane prijetnje i socijalnih normi]]></title_hr><title_en><![CDATA[]]></title_en><user_id>11126</user_id><user_firstLast_name>Dinka Čorkalo Biruški</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2015-10</proposal_call><code>DOK-2015-10-2477</code><acronim><![CDATA[IntegraNorm]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Psihologija, </scie_field_hr><scie_field_en>Psychology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Filozofski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Humanities and Social Sciences]]></institution_en><team_members_id>20453</team_members_id><team_members_names><![CDATA[ Doktorand: Lana Pehar ]]></team_members_names><keywords_hr><![CDATA[socijalna integracija, odnosi većine i manjine, međuetnički kontakt, međugrupna prijetnja, socijalne norme, obrazovanje manjina]]></keywords_hr><keywords_en><![CDATA[social integration, majority and minority relations, interethnic contact, intergroup threat, social norms, minority education]]></keywords_en><summary_hr><![CDATA[Cilj projekta je ispitati dugoročne efekte međuetničkog kontakta na ideološke i međuetničke stavove i ponašanja djece, adolescenata i njihovih roditelja, pripadnika većine i manjina, u četiri višeetničke zajednice u Republici Hrvatskoj. Jedinstven kontekst ispitivanja su manjinske i većinske škole, u kojima se nastava odvija na manjinskom jeziku (srpski, talijanski, mađarski i češki) ili pak na jeziku većine (hrvatski), a uključivanje čak četiri manjinske zajednice čini projektni prijedlog sasvim originalnim. Kao mogući mehanizmi djelovanja kontakta na međugrupne stavove i ponašanja istražit će se međugrupna prijetnja (realna i simbolička, te međugrupna tjeskoba), te, posebno, socijalne norme. Istraživanje predstavlja iskorak, jer zahvaća nekoliko aspekata međugrupne prijetnje kao posredujućeg mehanizma u odnosu međugrupnog kontakta i međugrupnih stavova i ponašanja, kao i temeljne izvore utjecaja u djece i adolescenata - roditeljske, vršnjačke i školske norme. U istraživanju će sudjelovati učenici osnovne i srednje škole, pripadnici četiri nacionalne manjine u Republici Hrvatskoj (Srbi, Talijani, Česi, Mađari) i većine, u dobi od 12 do 17 godina (N=1200) i njihovi roditelji (N=2400). Istraživanje kombinira kvalitativni i kvantitativni pristup. Kvalitativnom metodologijom (fokusne grupe, intervjui, ali i metoda opažanja) ispitat će se eksplicitne i implicitne školske norme o međuetničkom kontaktu, te potom formulirati instrument za njihovo mjerenje. Kvantitativni dio ispitivanja provest će se u dva vala, s razmakom od godine dana, te će se pratiti efekti međuetničkog kontakta na ideološke (stav prema multikulturnosti i asimilaciji), i na međugrupne stavove i ponašanja. Pri tome će se provjeriti pod kojim uvjetima, kako i koje socijalne norme utječu na vezu kontakta i međugrupnih stavova i ponašanja, te kakva je pri tome uloga međugrupne prijetnje. Rezultati projekta mogu biti relevantni za osmišljavanje integracijske uloge škole u višeetničkim zajednicama.]]></summary_hr><summary_en><![CDATA[The study aims to examine long-term effects of interethnic contact on ideological and interethnic attitudes and behaviors of majority and minority children, adolescents and their parents in four multiethnic communities in Croatia. A unique context of the study is provided by setting the research in the context of minority and majority schooling, where teaching is provided in either majority (Croatian) or minority languages (Italian, Serbian, Czech and Hungarian). Inclusion of multiple minority communities simultaneously makes this project sample rather unique. Intergroup threat (symbolic, realistic and intergroup anxiety) and especially social norms are hypothesized as being key mechanisms of influence of the interethnic contact. A novelty of the research is in encompassing multiple aspects of intergroup threat as mediating mechanisms in the link between intergroup contact and intergroup attitudes and behaviors, as well as and in assessing major sources of influence in adolescence – parental, peer and school norms. Participants will be majority and minority (Italian, Serb, Czech and Hungary) elementary and high-school students in Croatia, aged 12-17 (N=1200) and their parents (N=2400). The research combines qualitative and quantitative approach. Qualitative methods (focus groups, interviews and also observations) will be used to get an in-depth insight in the explicit and implicit contact-related school norms. These data will be used further for designing an instrument for measuring contact-related school norms. Quantitative data will be collected in a two-wave longitudinal study, and the effects of interethnic contact on ideological (assimilationism and multiculturalism) and intergroup attitudes and behaviors will be followed. It is proposed to test under what conditions, how and what social norms influence the link between the contact and intergroup attitudes and behaviors and what is the role of the intergroup threat in this context.]]></summary_en></project><project>
<id>3795</id><title_hr><![CDATA[Molekularni posrednici koštane resorpcije uvjetovane receptorom Fas u artritisu ]]></title_hr><title_en><![CDATA[]]></title_en><user_id>3882</user_id><user_firstLast_name>Nataša Kovačić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2015-10</proposal_call><code>DOK-2015-10-9897</code><acronim><![CDATA[MEFRA]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb School of Medicine]]></institution_en><team_members_id>21249</team_members_id><team_members_names><![CDATA[ Doktorand: Nina Lukač ]]></team_members_names><keywords_hr><![CDATA[artritis, Fas, osteoresorpcija, stanična loza, diferencijacija, apoptoza, upala]]></keywords_hr><keywords_en><![CDATA[arthritis, Fas, osteoresorption, lineage, differentiation, apoptosis, inflammation]]></keywords_en><summary_hr><![CDATA[Upalni artritisi su kronične zglobne bolesti, i važan zdravstveni problem zbog progresivne invalidnosti. Najčešći je reumatoidni arthritis (RA) praćen oštećenjem kosti i hrskavice, koji dovode do trajnih deformacija zgloba. Artritis se također često javlja tijekom sistemskog lupusa eritematosusa (SLE), uglavnom kao neerozivni artritis.Tijekom RA, upalne i imunološke stanice stvaraju mikrookoliš koji izaziva resorpciju kosti, potičući sazrijevanje i aktivnost osteoklasta, a kočeći sazrijevanje i aktivnost osteoblasta. Lijekovima poput bioloških sredstava može se promijeniti tijek bolesti, ali ograničeno je djelovanje na koštanu resorpciju. Sustav Fas/Fas ligand važan je regulatore homeostaze imunološkog sustava, a sve je više dokaza  o njegovoj važnosti u regulaciji koštane homeostaze. Inaktivacija receptora Fas štiti od gubitka kosti izazvanog nedostatkom estrogena, ali i gubitka kosti u upalnom artritisu, međutim stanične loze i signalni putevi koji posreduju taj učinak još nisu u potpunosti poznati. Korištenjem modela artritisa potaknutog antigenom (AIA, prema engl. antigen-induced arthritis) u miševa s izbačenim genom za Fas, te uzoraka sinovijalne tekućine bolesnika s RA i SLE, namjeravamo istražiti fenotip staničnih populacija odgovornih za kočenje osteoresorptivnih zbivanja, te utvrditi funkcijske promjene u tim stanicama globalnom analizom njihovog genskog izražaja. Nadalje, očekujemo da ćemo potvrditi značaj promijenjenih gena/bjelančevina njihovom inaktivacijom in vivo u mišjem modelu AIA, a važnost pojedine loze utvrdit ćemo uporabom miševa sa izbačenim genom za Fas u toj lozi. Analiza ljudskih uzoraka omogućit će razumijevanje značenja navedenih promjena u kliničkoj primjeni.   Naš pristup ima za cilj otkriti nove molekularne posrednike koštane resorpcije u upalnim artritisima, na razini specifičnoj za staničnu lozu. Predloženo istraživanje otvorit će nove mogućnosti za sprječavanje, ublažavanje i liječenje koštane resorpcije u upalnim zbivanjima.]]></summary_hr><summary_en><![CDATA[The inflammatory arthritides are chronic joint diseases, and a major health problem because of progressive disability. The most common form is rheumatoid arthritis (RA) characterized by bone and cartilage damage leading to deformity and permanent disability. Arthritis is also a common in systemic lupus erythematosus (SLE), mostly as a non-erosive form.In RA, inflammatory and immune cells create a microenvironment that favors osteoresorption by increasing osteoclast, and suppressing osteoblast differentiation and activity. Current treatment options such as biological therapeutics may modify the course of disease, but are not able to reverse osteoresorption.The Fas/Fas ligand system is important regulator of immune system homeostasis, and there is accumulating evidence for the role of this system in the regulation of bone homeostasis. Inactivation of Fas has a bone-sparing effect, preventing bone loss upon estrogen withdrawal, as well as in inflammatory arthritides, but the exact lineages and signaling pathways mediating this effect are not defined. Using the murine model of antigen-induced arthritis (AIA) in mice deficient for Fas, and synovial fluid samples from patients with RA and SLE, we aim to identify cell populations responsible for inhibition of osteoresorption, as well as functional alterations in these populations by analysing their gene expression profiles. In addition, we expect to confirm the role of identified genes/molecules by their inactivation in vivo in the murine model of AIA, and the role of a lineage using conditional lineage-specific models of Fas-inactivation. The analysis of human samples will allow for the translation to the clinical setting. Our approach aims to identify novel cellular/molecular drivers of bone resorption in arthritis, on a lineage-specific level. Proposed studies will provide new targets for preventing, reducing, and potentially reversing the osteoresorptive process which is a consequence of inflammatory events.]]></summary_en></project><project>
<id>3797</id><title_hr><![CDATA[Fiziološki i stereokemijski važni kompleksi bakra(II) s aminokiselinama: molekulsko modeliranje kombinirano s eksperimentalnim istraživanjima]]></title_hr><title_en><![CDATA[]]></title_en><user_id>19641</user_id><user_firstLast_name>Ante Miličević</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2015-10</proposal_call><code>DOK-2015-10-4185</code><acronim><![CDATA[CopperAminoAcidates]]></acronim><duration>02.12.2016 - 20.05.2024</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, </scie_field_hr><scie_field_en>Chemistry, </scie_field_en><institution_hr><![CDATA[Institut za medicinska istraživanja i medicinu rada]]></institution_hr><institution_en><![CDATA[Institute for Medical Research and Occupational Health]]></institution_en><team_members_id>21234</team_members_id><team_members_names><![CDATA[ Doktorand: Jelena Budimčić ]]></team_members_names><keywords_hr><![CDATA[bakar, aminokiseline, molekulsko modeliranje, DFT, MM, MD, rendgenska strukturna analiza, NMR čvrstog stanja, cis-trans izomerija, fiziološki spojevi]]></keywords_hr><keywords_en><![CDATA[copper, amino acids, molecular modelling, DFT, MM, MD, X-ray structure analysis, solid-state NMR, cis-trans isomerism, physiological compounds]]></keywords_en><summary_hr><![CDATA[Strukturna istraživanja kompleksa bis(amino acidato)bakra(II), Cu(aa)2, intenzivnije započeta prije oko 45 godina još traju jer su motivirana činjenicama da su to (1) biološki važni spojevi budući da sudjeluju u skladištenju i prijenosu bakra do mjesta u organizmu gdje u optimalnim koncentracijama taj esencijalan element ima važne fiziološke uloge, (2) modelni spojevi za vezivna mjesta za bakar u metaloproteinima, (3) stereokemijski zanimljivi spojevi. Unatoč intenzivnim eksperimentalnim istraživanjima fizioloških Cu(aa)2 posljednjih 40 godina, njihova kompletna geometrija u otopinama uglavnom je nepoznata. Naše je istraživanje bis(L-histidinato)bakra(II) primjenom teorije funkcionala gustoće (Density Functional Theory, DFT) prvo razjasnilo strukturu tog fiziološkog spoja u vodenoj otopini pri fiziološkim uvjetima (Eur J Inorg Chem 2014: 198). Nastavljajući se na naša prethodna istraživanja, glavni je cilj projekta dobiti nove rezultate o fizikalno-kemijskim svojstvima (strukture, energije, vibracije, cis-trans izomerija, konformacijske promjene) u vakuumu, vodenoj otopini i kristalnom okruženju izabranih Cu(aa)2 zbog njihove biološke važnosti i stereokemijske raznolikosti primjenom metoda molekulskog modeliranja (DFT, molekulska mehanika, molekulska dinamika) i eksperimentalnih metoda (rendgenska strukturna analiza, spektroskopija NMR čvrstog stanja). Očekujemo da ćemo kombiniranjem tim metoda pridonijeti rješavanju još uvijek neriješenih pitanja (1) točne geometrije u otopini i čvrstom stanju, (2) procesa na molekulskoj razini. Budući da je interes za istraživanje bakrovih kompleksa kao antiproliferacijskih spojeva znatno porastao u posljednjih nekoliko godina, a detaljna fizikalno-kemijska karakterizacija je prvi nužan korak u istraživanju, realno se očekuje da će novi rezultati pridonijeti otkrivanju novih lijekova. Rezultati istraživanja će značajno unaprijediti znanstvene spoznaje i primjene u bioanorganskoj kemiji, biofizici, biologiji i medicini.]]></summary_hr><summary_en><![CDATA[The structural studies of bis(amino acidato)copper(II) complexes, Cu(aa)2, which started intensively in the 1960s and continue up to date, have been motivated by the facts that these complexes are (1) biologically important as a part of the accessible physiological pool for transport and storage of an essential element copper, (2) appropriate models for copper-binding sites in metalloproteins, (3) sterochemically interesting compounds. Despite intensive experimental studies of physiological Cu(aa)2 during the last 40 years, their exact structures in solutions generally remain unresolved. Our density functional theory (DFT) study of bis(L-histidinato)copper(II) (Eur J Inorg Chem 2014: 198) is the first that clarified the structure of that physiological compound in aqueous solution at physiological conditions. Based on our previous studies, the main goal of the project is to obtain new results on the physico-chemical properties (structure, energy, vibrations, cis-trans isomerism, conformational changes) in different surroundings (vacuum, aqueous solution, solid state) of selected Cu(aa)2 because of their biological importance and stereochemical diversity by using the molecular modelling (DFT, molecular mechanics, molecular dynamics) and experimental (X-ray diffraction, solid-state NMR) methods. By combining these methods we expect to contribute to solving yet unresolved issues of (1) the exact geometries in solution and solid state, (2) the processes occurring at the molecular level. The new results will contribute to understanding the data required in the discovery of new potential drugs since the detailed physico-chemical characterisation is a necessary first step in the drug development. It is worth mentioning that the interest in copper coordination complex research as antiproliferative agents has markedly increased in the last few years. We expect our results to have an impact on applications in bioinorganic chemistry, biophysics, biology, and medicine. ]]></summary_en></project><project>
<id>3798</id><title_hr><![CDATA[Razvoj supramolekulskih receptora kationa i aniona]]></title_hr><title_en><![CDATA[]]></title_en><user_id>7690</user_id><user_firstLast_name>Vladislav Tomišić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2015-10</proposal_call><code>DOK-2015-10-6341</code><acronim><![CDATA[SupraCAR]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, </scie_field_hr><scie_field_en>Chemistry, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>22634</team_members_id><team_members_names><![CDATA[ Doktorand: Katarina Leko ]]></team_members_names><keywords_hr><![CDATA[receptori iona, kaliksareni, dehidracetna kiselina, kompleksiranje, solvatacija, vodikove veze, termodinamika  ]]></keywords_hr><keywords_en><![CDATA[ion receptors, calixarenes, dehydroacetic acid, complexation, solvation, hydrogen bonding, thermodynamics]]></keywords_en><summary_hr><![CDATA[Razvoj efikasnih i selektivnih receptora nabijenih kemijskih vrsta od velike je važnosti. U okviru ovog projekta dizajnirat će se, sintezirati i karakterizirati brojni takvi spojevi. Priredit će se niz novih derivata kaliksarena koji bi trebali efikasno i selektivno vezati razne katione i anione. Neki od tih spojeva predviđeni su da mogu poslužiti u analitičke svrhe, posebice kao ekstraktanti, drugi će sadržavati fluorescentne ili aminokiselinske podjedinice, dok će prilikom dizajna jednog dijela kaliksarenskih derivata posebna pažnja biti usmjerena poboljšanju njihove topljivosti u vodi. Također će se prirediti niz derivata dehidracetne kiseline kao anionskih receptora koji će sadržavati aminske, amidne, ureidne i tioureidne podjedinice. Kompleksacijski afiniteti svih navedenih spojeva prema raznim supstratima proučit će se sveobuhvatnim pristupom koji uključuje termodinamička, komputacijska i strukturna istraživanja. Koristit će se brojne spektroskopske i elektrokemijske metode, kao i (mikro)kalorimetrija, što će omogućiti određivanje pouzdanih termodinamičkih podataka (konstante stabilnosti, standardne Gibbsove energije, entalpije i entropije reakcija kompleksiranja i otapanja). Bit će provedene i simulacije molekulske dinamike istraživanih sustava, što će pripomoći dizajnu novih spojeva te interpretaciji eksperimentalnih nalaza. Pored toga, uz rezultate postignute spektroskopijom NMR te rentgenskom strukturnom analizom, te će simulacije pružiti uvid u strukturne karakteristike receptora i njihovih kompleksa. Posebna će pažnja biti posvećena utjecaju vodikovih veza i solvatacije na ravnoteže reakcija kompleksiranja. U tu svrhu koristit će se brojna otapala različitih solvatacijskih svojstava i afiniteta za stvaranje vodikovih veza. Očekuje se da će dobivene termodinamičke informacije omogućiti stjecanje detaljnog uvid u reakcije kompleksiranja, kao i utjecaj otapala na njihov ishod, što bi trebalo olakšati i ubrzati daljnji razvoj supramolekulskih receptora.]]></summary_hr><summary_en><![CDATA[The importance of development of efficient and selective receptors of charged species has been widely recognised. In the framework of this project, a variety of such compounds will be designed, synthesised, and characterised. A series of novel calixarene derivatives capable of strongly and selectively binding cations and anions will be prepared. Some of these compounds are aimed to be efficient liquid-liquid extraction agents whereas the others will be designed to be water-soluble or to bear fluorescent and amino-acid substituents. Another class of anion receptors which will be synthesised comprises amine, amide, urea, and thiourea derivatives of dehydroacetic acid. The complexation abilities of all the compounds mentioned towards various substrates will be explored by using an integrated approach which includes thermodynamic, computational, and structural studies. A number of spectroscopic and electrochemical methods as well as (micro)calorimetry will be employed. That should yield detailed and reliable thermodynamic data (stability constants, reaction and solution Gibbs energies, enthalpies and entropies). In order to facilitate the design of the targeted molecules and to assist the interpretation of the experimental results, the molecular dynamics simulations of the systems studied will be carried out. This will, together with the results of NMR studies and that of solid-state X-ray diffraction investigations, also ensure information about structural characteristics of the receptors and their complexes. Particular attention will be focused on the hydrogen-bonding and solvation effects on the equilibria of binding reactions. For that reason, many solvents with different solvation and hydrogen-bonding affinities will be used. The obtained thermodynamic information is expected to provide a detailed insight into the complexation processes and the influence of medium on the reactions studied, which will allow further development of efficient supramolecular receptors.]]></summary_en></project><project>
<id>3800</id><title_hr><![CDATA[Otkrivanje novih proteinskih interakcija kao podloga za nove pristupe liječenju melanoma čovjeka]]></title_hr><title_en><![CDATA[]]></title_en><user_id>1107</user_id><user_firstLast_name>Maja Herak Bosnar</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2015-10</proposal_call><code>DOK-2015-10-9044</code><acronim><![CDATA[ProNetMel]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>22818</team_members_id><team_members_names><![CDATA[ Doktorand: Martina Radić ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[melanoma, protein interactions, p53, p73, nm23, Gli]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Metastatic melanoma represents a major clinical problem due to rising incidence and resistance to available therapies. Therefore, there is a necessity for developing novel molecular approaches to treat this disease. Unlike other tumors, in melanoma p53 is relatively rarely mutated. However, overexpressed p53 fails to function as a tumor suppressor and tumor cells continue to proliferate and spread. This suggests that regulation of p53 activity depends on the interplay between p53 and its binding partners. Based on current state of knowledge, we hypothesize that p53 function in malignant melanoma might be altered through the interactions with p53 small molecular weight and p73 isoforms, nm23/NDPK and Gli families of proteins. Thus we will search for p53 protein binding partners in melanoma. The interactions identified by mass spectrometry will be further confirmed using microarray-based approaches and co-immunoprecipitation techniques. Furthermore, the expression profile of genes/proteins of interest in panel of melanoma cell lines and melanoma tissue samples will be investigated. The potential impact of the identified p53 interacting partners on its transcriptional activity and the stimulation of apoptosis will be determined. The depletion of partners using siRNA technology would confirm the involvement of selected proteins on p53 activity. The subcellular localization of the proteins in complex will be revealed by advanced fluorescent microscopy methods on state-of-the-art instrumentation what would give us the insight on dynamics of their interactions. The proposed research could provide a possible explanation why p53 function in melanoma is abrogated. The aim of this project is to determine the complexity of p53 interactions and their role in the onset and progression of human melanoma and offer new, innovative solutions in diagnosis, prognosis and therapy.]]></summary_en></project><project>
<id>3801</id><title_hr><![CDATA[Rana faza razvoja kompleksa za stvaranje viriona tijekom citomegalovirusne infekcije]]></title_hr><title_en><![CDATA[]]></title_en><user_id>6604</user_id><user_firstLast_name>Pero Lučin</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2015-10</proposal_call><code>DOK-2015-10-2825</code><acronim><![CDATA[]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Medicine]]></institution_en><team_members_id>21237</team_members_id><team_members_names><![CDATA[ Doktorand: Marina Marcelic ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>3802</id><title_hr><![CDATA[MORUS - Unmanned system for maritime security and environmental monitoring]]></title_hr><title_en><![CDATA[]]></title_en><user_id>5244</user_id><user_firstLast_name>Stjepan Bogdan</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2015-10</proposal_call><code>DOK-2015-10-2875</code><acronim><![CDATA[]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Elektrotehnika, </scie_field_hr><scie_field_en>Electrical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id>22725</team_members_id><team_members_names><![CDATA[ Doktorand: Marko Car Car ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>3803</id><title_hr><![CDATA[Programski sustavi u evoluciji: analiza i inovativni pristupi pametnom upravljanju]]></title_hr><title_en><![CDATA[]]></title_en><user_id>1409</user_id><user_firstLast_name>Tihana Galinac Grbac</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2015-10</proposal_call><code>DOK-2015-10-2580</code><acronim><![CDATA[EVOSOFT]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Računarstvo, </scie_field_hr><scie_field_en>Computer sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Tehnički fakultet]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Engineering]]></institution_en><team_members_id>22612</team_members_id><team_members_names><![CDATA[ Doktorand: Ana Vranković ]]></team_members_names><keywords_hr><![CDATA[evolucija, kompleksni softverski sustavi, pametno upravljanje, distribucije neispravnosti, struktura]]></keywords_hr><keywords_en><![CDATA[evolution, complex software system, smart management, fault distributions, structure]]></keywords_en><summary_hr><![CDATA[Kompleksni programski sustavi koji se evolucijski razvijaju (EVOSOFT) postali su središnji sve većeg broja aplikacija, proizvoda i usluga, a koji su potpora svakodnevnim ljudskim aktivnostima iz svih gospodarskih sektora. Često su to distribuirani sustavi , heterogeni , decentralizirani i međusobno zavisni, koji rade u dinamičnim i nepredvidljivim uvjetima, pa su njihova dostupnost i pouzdanost postale ključna svojstva potrebna za njihov rad i budući razvoj. Novoi još neistraženo područje istraživanja a koje se obrađuje u ovom projektu je razumjeti kako apstraktne programske strukture i lokalna obilježja sustava utječu na distribuciju neispravnosti, a čime se utječe na kritična svojstva sustava, među kojima je dostupnost i pouzdanost te razvijati inovativne pristupe za pametno upravljanje njihovim izvođenjem i evolucijom. Potrebno je za naglasiti da se ovdje suočavamo s potpuno novim pojavama, sličnim ljudskoj evoluciji, ali koje su proizvedene ljudskim intelektom. Temelji i teorije iz drugih disciplina kojima je cilj razumjeti ponašanje kompleksnih sustava, evolucije te ljudsko razmišljanje mogle bi ovdje biti primijenjive. Novi rezultati otvoriti će nove mogućnosti u mnogim znanstvenim područjima, osobito u teoriji kompleksnih sustava i njenih primjena, te tako međudjelovati sa širokim spektrom znanosti, od prirodnih znanosti kao što su to biomedicina pa sve do društvenih znanosti . Industrijsko iskustvo prikupljeno iz empirijskog pristupa programskom inženjerstvu je iznimno važno za daljnji razvoj discipline programskog inženjerstva. Nove teorije ne mogu biti djelotvorne i primjenjive u industriji, bez temeljnog razumijevanja EVOSOFT ponašanja . Glavni cilj ovog projekta je da će ispuniti taj jaz između empirijskih dokaza i teoretskih modela . Kako bi ostvarili taj cilj kombiniramo empirijska i teoretska znanja tako što ćemo:• ponoviti studije i potvrditi empirijske principe i metode i na kojima želimo graditi nove teorije ,• definirati strukturalne ovisnosti za primjenu empirijskih principa, metoda ,• definirati formalne modele i inovativne načine pametnog upravljanja .]]></summary_hr><summary_en><![CDATA[Evolving complex software systems (EVOSOFT) have become a central part of a rapidly growing range of applications, products and services supporting daily human activities from all economic sectors. As they are often distributed, heterogeneous, decentralized and inter-dependent, and operating in dynamic and unpredictable environments, availability and reliability become key properties for its operation and future evolution. The novel and still unexplored area of research addressed in this project is to understand how abstract software structures and local system properties influence fault distributions, thus affecting mission critical system properties, among which availability and reliability and to develop innovative approaches for smart management of their operation and evolution. We are facing with completely new phenomena, similar to human evolution, but produced by human intellect. Foundations and theories from other disciplines aiming to understand complex system behavior, evolution and human reasoning could be applied. New findings would open new opportunities in many scientific fields, especially in complex systems theory and its applications, thus interacting with a wide spectrum of sciences, from natural sciences such as biomedicine to social sciences. Industrial experience gathered by systematic Empirical Software Engineering approach is extremely important for further evolution of software engineering discipline. New theories cannot provide effective means for industry without fundamental understanding of EVOSOFT behavior. The main aim of this project is to fulfill this gap between empirical evidence and theoretical models. In that aim we combined empirical and theoretical skills aiming to: • replicate studies and confirm empirical principles and methods and define a solid base to ground new theories, • define structural dependencies for applicability of empirical principles, methods, • define formal models and innovative approaches for smart management.]]></summary_en></project><project>
<id>3805</id><title_hr><![CDATA[Algoritmi za mjerenje sustavskog rizika]]></title_hr><title_en><![CDATA[]]></title_en><user_id>13406</user_id><user_firstLast_name>Zvonko Kostanjčar</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2015-10</proposal_call><code>DOK-2015-10-3270</code><acronim><![CDATA[ASYRMEA]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Elektrotehnika, </scie_field_hr><scie_field_en>Electrical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id>21046</team_members_id><team_members_names><![CDATA[ Doktorand: Stjepan Begušić ]]></team_members_names><keywords_hr><![CDATA[sustavski rizik, kompleksni sustavi, mrežna dinamika, rijetkost, vremenski diskretni signali]]></keywords_hr><keywords_en><![CDATA[systemic risk, complex systems, network dynamics, sparsity, discrete time signals]]></keywords_en><summary_hr><![CDATA[Razmatramo kompleksni sustav, poput nuklearne elektrane, koji je građen od velikog broja podsustava s određenom vjerojatnošću kvara koje nisu nezavisne. Zanima nas vjerojatnost kvara cijelog sustava koji se događa kad neki podskup podsustava zakaže, tj. zanima nas sustavski rizik. Kako možemo modelirati takvu situaciju i procijeniti sustavski rizik? Na žalost, to je vrlo teško i nismo dobri u tome, pa tako npr. red veličine vjerojatnosti kvara neke nuklearne elektrane još uvijek nije poznata. Čini se da je to zato što je većina poznatih korelacijskih struktura u vjerojatnosti nisko dimenzionalna ili čak jednodimenzionalna. Međutim, u kompleksnim sustavima su korelacijske strukture visoko dimenzionalne i obično ne vrijedi pretpostavka nezavisnosti. Cilj ovog istraživačkog projekta je pronaći učinkovite algoritme za mjerenje sustavskog rizika definiranjem novih klasa modela višedimenzionalnih korelacijskih struktura u velikom skupu slučajnih varijabli. Definirani modeli moraju biti računalno izvedivi i dovoljno jednostavni da im se parametri mogu estimirati iz podataka u različitim primjenama višedimenzionalne analize podataka.U ovom projektu ćemo nastaviti koristiti metode matematičkog i računalnog modeliranja, konkretno: kompleksnih mreža, rijetkih estimacija i koncentracije mjere. Koristeći ovaj pristup smo već postigli vrlo važne rezultate, poput uvida u nastajanje zakona potencija i dvofaznog ponašanja u fluktuacijama financijskih tržišta. Također bismo s ovim pristupom željeli bolje razumjeti sustavski rizik i stabilnost kompleksnih sustava (npr. financijskog sustava). Potreba za znanstveno utemeljenom mjerom sustavskog rizika nije samo akademska zato što se diljem svijeta pokušava smanjiti rizik i troškovi sustavskih kriza.]]></summary_hr><summary_en><![CDATA[Consider a complex system (such as a nuclear plant) that is made from many subsystems which themselves have certain probabilities of failure, and these probabilities are not independent. Suppose that we are interested in the probability of failure of the entire system, failure that occurs when certain subset of the subsystems fail, i.e. we are interested in the systemic risk. How do we model such a situation and estimate the systemic risk? Unfortunately, this is very difficult, and we are not very good at it, e.g. the order of magnitude of the probability of failure of a nuclear plant is still ungraspable. It seems that this is because most of the familiar correlation structures in probability are low-dimensional, or even one-dimensional. However, correlation structures in complex systems are high-dimensional and usual independence assumption is seriously violated. The goal of this research project is to find efficient algorithms for systemic risk measurement by defining a new class of models of high-dimensional correlation structures in a large collection of random variables. The defined models should be computationally tractable and simple enough so that one can bring them to data and use it for various applications in high-dimensional data analysis.In this project we will continue to use the methods of mathematical and computational modeling, specifically: complex networks, sparse estimation, and concentration of measure. With this approach, we have already obtained very important results, like an insight into the emergence of power-law and two-phase behavior in the financial market fluctuations. Also, with this approach we would like to better understand the basic mechanisms that underlie systemic risk and the stability of the complex systems (e.g. financial system). The need for scientific foundations for a systemic risk measure is more than an academic concern as different people around the world consider how to reduce the risks and costs of systemic crises.]]></summary_en></project><project>
<id>3807</id><title_hr><![CDATA[CRISPR Adaptation - the basis for prokaryotic adaptive immunity]]></title_hr><title_en><![CDATA[]]></title_en><user_id>4503</user_id><user_firstLast_name>Ivana Ivančić Baće</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2015-10</proposal_call><code>DOK-2015-10-6320</code><acronim><![CDATA[]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Biologija, </scie_field_hr><scie_field_en>Biology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>22812</team_members_id><team_members_names><![CDATA[ Doktorand: Marin Radovčić ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>3811</id><title_hr><![CDATA[Procesna i poslovna inteligencija za poslovnu izvrsnost ]]></title_hr><title_en><![CDATA[]]></title_en><user_id>1246</user_id><user_firstLast_name>Vesna Bosilj Vukšić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2015-10</proposal_call><code>DOK-2015-10-9225</code><acronim><![CDATA[PROSPER]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Informacijske znanosti, </scie_field_hr><scie_field_en>Information sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Ekonomski fakultet u Zagrebu]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Economics and Business]]></institution_en><team_members_id>22659</team_members_id><team_members_names><![CDATA[ Doktorand: Ana-Marija Stjepić ]]></team_members_names><keywords_hr><![CDATA[procesna inteligencija, poslovna inteligencija, upravljanje poslovnim procesima, mjerenje i upravljanje performansama, rudarenje podataka, softver]]></keywords_hr><keywords_en><![CDATA[process intelligence, business intelligence, business process management, performance measurement and management, data mining, software]]></keywords_en><summary_hr><![CDATA[Svrha projekta PROSPER je istražiti primjenu procesne (PI) i poslovne inteligencije (BI) u poduzećima i njihov utjecaj na uspješnost poslovanja, s posebnim fokusom na korištenje modernih tehnologija (kao što su sustavi za upravljanje poslovnim procesima, rudarenje podataka, simulacijski softver) pri implementaciji ovih koncepata. Primijenit će se odgovarajući istraživački pristup. Koristiti će se statističke metode (kao što su modeli strukturnih jednadžbi - SEM) i metode kvalitativnog istraživanja (na primjer kvalitativno istraživanje kulturalnih razlika primjene procesne i poslovne inteligencije u u Hrvatskoj, Sloveniji, Austriji i Bosni i Hercegovini). Projekt je multidisciplinaran i više-razinski, a njegovi su ciljevi hijerarhijski strukturirani.Na najvišoj razini (L1) istražit će se primjena i zrelost procesne i poslovne inteligencije u  zemljama iz kojih dolaze suradnici na projektu. Provest će se empirijsko istraživanje, dobiveni rezultati analizirati će se kvantitativnim metodama (regresijska i faktorska analiza). Na drugoj razini (L2) istražit će se kritični faktori uspješnosti primjene koncepata procesne i poslovne inteligencije. U tu svrhu će se koristiti kvalitativne (studije slučaja, polu-strukturirani intervjui)  i kvantitativne metode (modeli strukturnih jednadžbi).  Rezultati istraživanja koristiti će se za razvoj modela za mjerenje procesnih performansi. Na trećoj razini (L3) testirati će se primjenjivost rezultata istraživanja iz prethodnih razina (L1 i L2), a u tu svrhu će se provesti kvalitativno istraživanje u poduzećima. Kroz studije slučaja testirati će primjena procesne i poslovne inteligencije i njihov utjecaj na uspješnost poslovanja.  Razviti će se modeli iz područja poslovne inteligencije za neke specifične poslovne slučajeve i djelatnosti. Primjena ovih modela omogućiti će uspješnije poslovanje. ]]></summary_hr><summary_en><![CDATA[The aim of the PROSPER project is to examine the adoption of the process intelligence (PI) and business intelligence (BI) in organizations, as well as to foresee their impact on business performance using cutting-edge technologies (e.g. business process management systems, data mining, simulation software) and research approach (e.g. cross-cultural research, structural equation modelling) with the assistance of multi-country (Croatia, Slovenia, Austria, Bosnia and Herzegovina) and interdisciplinary team of university researchers. The project is multidisciplinary and multi-levelled due to the hierarchical structure of its objectives.At the highest level (L1), the adoption and maturity of PI and BI will be explored in organizations in Croatia, Slovenia, Bosnia and Herzegovina and Austria. A quantitative empirical research results will be analysed using regression and factor analysis. At the middle level (L2), the impact of critical factors (e.g. organizational culture and structure) on PI and BI adoption will be analyzed. L2 research results will be explored using qualitative (e.g. case study, semi-structured interviews) and quantitative methods (e.g. structural equation modelling), the goal being development of the process performance measurement model. At the third level (L3), the practical applicability of the L1 and L2 research results will be tested and evaluated using specific business cases in PI and BI adoption for business performance. Models will be developed for the usage of BI in some specific business cases and industries, with the goal of increasing business performance.]]></summary_en></project><project>
<id>3812</id><title_hr><![CDATA[Vojnički život i slike ratnika u hrvatskom pograničju od 16. stoljeća do 1918.]]></title_hr><title_en><![CDATA[]]></title_en><user_id>265</user_id><user_firstLast_name>Alexander Buczynski</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2015-10</proposal_call><code>DOK-2015-10-2397</code><acronim><![CDATA[MLWICB]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Povijest, </scie_field_hr><scie_field_en>History, </scie_field_en><institution_hr><![CDATA[Hrvatski institut za povijest]]></institution_hr><institution_en><![CDATA[Croatian Institute of History]]></institution_en><team_members_id>3212</team_members_id><team_members_names><![CDATA[ Doktorand: Juraj Balić ]]></team_members_names><keywords_hr><![CDATA[kulturna povijest, povijesna demografija, Habsburška Monarhija, Venecija, Vojna krajina, Dalmacija, gerila, vojni popisi, vojna revolucija, novine]]></keywords_hr><keywords_en><![CDATA[cultural history, historical demography, Habsburg Monarchy, Venice, Military Frontier, Dalmatia, guerilla, muster rolls, military revolution, news]]></keywords_en><summary_hr><![CDATA[Prinosi vojnika s hrvatskog pograničja u vojnim postrojbama Habsburške Monarhije, Mletačke Republike, Osmanskog Carstva i Francuskog Carstva neprijeporna su činjenica. Zahvaljujući opsežnom i vremenski kontinuirano sačuvanom arhivskom gradivu koje se odnosi na razdoblje ranog novog vijeka i dugog 19. stoljeća, ta se problematika može sustavno istraživati primjenom multidisciplinarnih metoda. Cilj ovog projekta je istražiti demografske, društveno-ekonomske i političke prilike u hrvatskom pograničju, kao i utvrditi uzročno-posljedične veze između navedenih prilika (razvojnih sastavnica) koje su činile svakodnevnicu hrvatskih vojnika i kreirale njihov identitet. Istraživanje će se usredotočiti na Ličku i Otočku pukovniju u Vojnoj krajini, Zadar i Kotor kao središnja mletačka vojna uporišta na istočnoj obali Jadrana, Dubrovačku Republiku te Dalmaciju u vrijeme austrijske i francuske uprave. Rekonstrukcija svakodnevice i identiteta pripadnika vojničkog društva objedinit će: 1. demografska kretanja (natalitet, fertilitet i mortalitet), migracije, društveno-ekonomski kontekst (dobna, spolna i profesionalna struktura); 2. vojni i ratni kontekst (vojna organizacija i obuka, “mali rat“ – “partizanski način ratovanja“ – umijeće ratovanja, imidž i samosvijest hrvatskih vojnika); 3. geo-politički kontekst (upravno-pravna podjela, tranzicije vlasti). Jedan od temeljnih ciljeva istraživačkog tima jest znanstveno obraditi te kroz bazu podataka prikazati što veći broj vojnih popisa, matičnih knjiga, popisa stanovništva, popisa stradalnika, zemljišnih knjiga koji se odnose na Ličku i Otočku pukovniju, Zadar, Dubrovačku Republiku i Kotor. Rečeni bi izvori, odnosno podatci, bili kreirani i dostupni u on-line bazi otvorenog pristupa te integrirani u svjetske mreže sličnih baza kao što su EHPS-Net i MOSAIC i kao takvi služili bi multidisciplinarnoj svrsi.]]></summary_hr><summary_en><![CDATA[The contribution of soldiers from Croatian borderlands to the armed forces of the Habsburg Monarchy, Republic of Venice, Ottoman Empire and French Empire is beyond dispute. Thanks to comprehensive and continuous archive records relevant to the early modern period and long nineteenth century, this issue can be thoroughly researched on a multidisciplinary level. This project aims to explore demographic, socio-economic and political circumstances in Croatian borderlands, and to examine cause and effect relationships between these circumstances (developmental components) that made up the everyday life of Croatian soldiers, their families and households, and formed their identity. Research will focus on the Otočac and Lika Regiments of the Military Frontier, Zadar and Kotor as central strongholds of the Republic of Venice on the East Adriatic, the Republic of Dubrovnik and Dalmatia during the French and Austrian administration. The reconstruction of everyday life and the identity of the martial people that inhabited these borderlands will include: 1. demographic data (birth rates, fertility and mortality), migrations and the socio-economic context (age, gender and professional structure); 2. the military and war context (military organization and training, la petite guerre - partisan warfare - and the art of war, images and self-awareness of Croatian soldiers); 3. the geo-political context (administrative and legal organization, government transitions). One of the main objectives of the research team is to process a large quantity of muster rolls and other military lists, birth, marriage and death registers, casualty lists, land registers etc, covering the Otočac and Lika Regiments, Zadar, Dalmatia, Republic of Dubrovnik and Kotor in order to create an open access database that can be integrated within networks as EHPS-Net and MOSAIC and will thus serve a multidisciplinary purpose.]]></summary_en></project><project>
<id>3813</id><title_hr><![CDATA[Razjašnjavanje sortne tipičnosti vina i maslinovih ulja od hrvatskih domaćih sorti]]></title_hr><title_en><![CDATA[]]></title_en><user_id>4924</user_id><user_firstLast_name>Igor Lukić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2015-10</proposal_call><code>DOK-2015-10-2570</code><acronim><![CDATA[TYPICRO]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Prehrambena tehnologija, </scie_field_hr><scie_field_en>Food technology, </scie_field_en><institution_hr><![CDATA[Institut za poljoprivredu i turizam]]></institution_hr><institution_en><![CDATA[Institute of Agriculture and Tourism in Poreč]]></institution_en><team_members_id>21020</team_members_id><team_members_names><![CDATA[ Doktorand: Ivana Horvat ]]></team_members_names><keywords_hr><![CDATA[sortna tipičnost, vino, maslinovo ulje, domaće sorte, Hrvatska, hlapljive arome, fenoli, senzorna analiza, kemometrija, tehnologija]]></keywords_hr><keywords_en><![CDATA[varietal typicity, wine, olive oil, native varieties, Croatia, volatile aroma, phenols, sensory evaluation, chemometrics, technology]]></keywords_en><summary_hr><![CDATA[Projekt TYPICRO nastoji razjasniti sortnu tipičnost vina i maslinovih ulja od hrvatskih domaćih sorti. Odabrati će se tipični uzorci te će se definirati tipične senzorne karakteristike i deskriptori od strane profesionalnih certificiranih senzornih ocjenjivača. Izraditi će se novi obrazac za kvantitativno deskriptivno senzorno ocjenjivanje tipičnosti. Uzorci tipičnih vina i maslinovih ulja od domaćih i introduciranih sorti biti će podvrgnuti detaljnom kemijskom profiliranju i kvantifikaciji pomoću mikroekstrakcije na čvrstoj fazi uz plinsku kromatografiju-spektrometriju masa (HS-SPME-GC-MS) za hlapljive spojeve arome, te tekućinske kromatografije visokog razlučivanja s detekcijom nizom dioda (HPLC-DAD) za fenole. Uzorci će se senzorno ocijeniti kvantitativnom deskriptivnom analizom. Rezultati će biti obrađeni kemometrijskim metodama. Prototipski proizvodi domaćih sorti biti će podvrgnuti dubinskoj metabolomskoj i olfaktometrijskoj (AEDA s GC-O) analizi u svrhu identifikacije novih spojeva, te određivanja hijerarhije hlapljivih sastojaka odnosno njihovog relativnog doprinosa tipičnoj aromi. Očekivani rezultati uključuju određivanje tipičnog kemijskog sastava i senzornih svojstava sortnih vina i maslinovih ulja od domaćih i introduciranih sorti, utvrđivanje fizikalno-kemijske osnove i nositelja senzorne tipičnosti, utvrđivanje biljega sortnog podrijetla za diferencijaciju između tipičnih proizvoda od domaćih i introduciranih sorti, određivanje nepromjenjivih osobina i pokazatelja sortnog podrijetla unatoč unutarsortnoj varijabilnosti, te određivanje unutarsortnih razlika. Kroz niz poljskih i tehnoloških pokusa identificirati će se čimbenici koji doprinose isticanju i očuvanju tipičnosti. Biti će ispitan stupanj prepoznatljivosti tipičnih domaćih vina i ulja među stručnjacima, znalcima i proizvođačima. Rezultati ovog projekta predstaviti će se kroz niz javnih predavanja, konferencija i radionica, te će biti objavljeni u međunarodno relevantnim znanstvenim časopisima.]]></summary_hr><summary_en><![CDATA[TYPICRO project aims to unravel the varietal typicity of wines and olive oils from Croatian native varieties. Typical wines and olive oils will be selected and their typical sensory characteristics and descriptors will be defined by professional certified tasters. A novel quantitative descriptive sensory evaluation form for the assessment of typicity will be created. Typical samples from native and introduced varieties will be subjected to chemical profiling and quantification by headspace solid-phase microextraction with gas chromatography-mass spectrometry (HS-SPME-GC-MS) for volatile aromas, and high performance liquid chromatography with diode-array detection (HPLC-DAD) for phenolics. Quantitative descriptive sensory evaluation will be performed. The results will be processed by chemometrics. The prototypical monovarietal products will be subjected to in-depth metabolomic and olfactometric analysis to identify previously unidentified compounds, and to determine the hierarchy of volatiles and their relative contribution to typical aroma. Expected results include: determination of typical chemical composition and sensory characteristics of wines and olive oils from native and introduced varieties in Croatia, determination of the physico-chemical basis and drivers of sensory typicity, determination of markers of varietal origin able to discriminate between typical products from native and introduced varieties, determination of unchanging characteristics and indicators that remain determinants of varietal origin despite intra-varietal variability, determination of intra-varietal differences. Factors that highlight and preserve varietal typicity will be identified through a set of field and technological experiments. The recognisability of typical products will be tested in blind-tasting trials. The outcomes of the project will be disseminated through public presentations, conferences and a workshop, and published in internationally relevant scientific journals.]]></summary_en></project><project>
<id>3814</id><title_hr><![CDATA[Strengthening adaptive immunity via innate immunity: enhancing the CD8 T cell response by using the NKG2D ligand expressed in a herpesvirus vector]]></title_hr><title_en><![CDATA[]]></title_en><user_id>4652</user_id><user_firstLast_name>Berislav Lisnić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2015-10</proposal_call><code>DOK-2015-10-9782</code><acronim><![CDATA[]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Medicine]]></institution_en><team_members_id>22696</team_members_id><team_members_names><![CDATA[ Doktorand: Tina Jenuš ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>3815</id><title_hr><![CDATA[Istraživanje razvoja, diferencijacije i evolucije životinja kroz genomiku bazalnih metazoa ]]></title_hr><title_en><![CDATA[]]></title_en><user_id>1187</user_id><user_firstLast_name>Kristian Vlahoviček</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2015-10</proposal_call><code>DOK-2015-10-6331</code><acronim><![CDATA[BAMGEN]]></acronim><duration>01.11.2016 - 31.12.2021</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Biologija, </scie_field_hr><scie_field_en>Biology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>25056</team_members_id><team_members_names><![CDATA[ Doktorand: Maja Kuzman ]]></team_members_names><keywords_hr><![CDATA[regulacija gena, genomika, transkriptomika, spužve, genomika raka]]></keywords_hr><keywords_en><![CDATA[gene regulation, genomics, transcriptomics, sponges, cancer genomics]]></keywords_en><summary_hr><![CDATA[Projekti velikih razmjera koji uključuju metode -omike priskrbili su veliku količinu znanja o molekularnim mehanizmima u stanicama i tkivima ljudi i modelnih organizama, te pružili mnoštvo informacija o raznolikosti staničnih procesa, poglavito genske regulacije. Ti su projekti ujedno razotkrili neizmjernu kompleksnost životinjske stanice, potencijal za diferencijaciju u stanice različitih tkiva, gubitak kontrole pri nastajanju raka, te time potakli niz dubljih pitanja na različitim područjima znanosti o životu: Kako funkcionira diferencijacija u specifične stanice tkiva? Koliko su mehanizmi genske regulacije očuvani kroz životinjsko carstvo? Odakle potječe kompleksnost procesa diferencijacije? I, konačno, koje je porijeklo višestaničnosti?  Bazalne životinje (Metazoa), ključne su za odgovore na ova pitanja: mi na njih namjeravamo odgovoriti proučavanjem ne-modelnih organizama na samom dnu životinjskog evolucijskog stabla - najjednostavnijim višestaničnim životinjama - spužvama (Porifera). Spužve su najstarije danas živuće životinje koje su se vjerojatno najranije odvojile na razvojnom stablu životinja, te posjeduju neka izvanredna svojstva koja ih čine idealnim modelom za istraživanja regulacije gena uključenih u razvoj: u bliskoj su simbozi s jednostaničnim prokariotima, sadrže mali broj osnovnih tipova stanica, nemaju pravih tkiva, organa ni zametnih listića, a istovremeno posjeduju mnoge gene uključene u rani razvoj i povezane s nastankom raka, kao i totipotentne stanice. Metodama komparativne genomike i transkriptomike, htjeli bismo istražiti procese unutar simbioze, kao i procese razvoja i diferencijacije stanica za koje vjerujemo da su naslijedile sve višestanične životinje.  Pomoću čvrste mreže suradnika, stručnjaka u području biologije Metazoa s iskustvom u  metodama genomike i računalne biologije kompleksnih sustava, te preliminarnim setom zanimljivih rezultata, namjeravamo odgovoriti na prethodno postavljena pitanja i interdisciplinarnim pristupom razjasniti neka od ključnih otvorenih pitanja na području genomike i evolucije čitavog životinjskog carstva.]]></summary_hr><summary_en><![CDATA[Large scale –omics projects have provided valuable knowledge on the molecular mechanisms occurring in cells and tissues of human and other related model organisms, delivering a wealth of information on the diversity of cellular processes, and in particular gene regulation. Yet, these projects have also uncovered the immense complexity of the animal cell, its potential to differentiate into various tissues, or spiral out of control by forming cancer, opening up even more profound questions on diverse fronts of the life sciences: How does tissue-specific cell differentiation work? How conserved are gene regulation mechanisms throughout animal kingdom? Where does complexity of differentiation originate from? And, finally, what is the origin of multicellularity?Basal metazoans hold key answers to these questions: we propose to tackle them by investigating the non-model organisms at the very base of the animal evolutionary tree – the simplest multicellular animals – sponges (Porifera). Sponges, are probably the earliest branching and the oldest extant animals. They hold remarkable properties that make them an excellent subject for studying developmental gene regulation: a handful of major cell types, no true tissues and organs, and no germ layers, but at the same time they are rich in early developmental genes associated to cancer and possessing totipotent cells. With the aid of comparative genomics and transcriptomics, we wish to explore developmental and cell differentiation processes that we believe are ancestral to all multicellular animals.With a strong collaboration network, expert base in metazoan biology, expertise in genomics and computational biology of complex systems, and a preliminary set of interesting results, we propose to answer the above questions through a truly interdisciplinary approach and elucidate some of the crucial open questions in genomics and evolution of the entire animal kingdom. ]]></summary_en></project><project>
<id>3818</id><title_hr><![CDATA[Molekularni mehanizmi ugradnje homolognih i heterolognih proteina u staničnoj stijenci kvasca i njihova primjena u biotehnologiji]]></title_hr><title_en><![CDATA[]]></title_en><user_id>359</user_id><user_firstLast_name>Vladimir Mrša</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2015-10</proposal_call><code>DOK-2015-10-2173</code><acronim><![CDATA[CEWAPROT]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Biotehnologija, </scie_field_hr><scie_field_en>Biotechnology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prehrambeno-biotehnološki fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Food Technology and Biotechnology]]></institution_en><team_members_id>25089</team_members_id><team_members_names><![CDATA[ Doktorand: Mateja Lozančić ]]></team_members_names><keywords_hr><![CDATA[stančna stijenka kvasca, proteini stanične stijenke, lokalizacija proteina, heterologna ekspresija, izlaganje na staničnoj površini, genetička imobili]]></keywords_hr><keywords_en><![CDATA[yeast cell wall, cell wall proteins, protein localization, heterologous expression, surface display, genetic immobilization]]></keywords_en><summary_hr><![CDATA[Stanična stijenka kvasca sastoji se od unutrašnjeg sloja glukana na koji su s vanjske strane vezani manoproteini. Velika je raznolikost među proteinima stijenke, ne samo u strukturama i aktivnostima, nego i u načinu na koji su ugrađeni u stijenku. Neki od njih vezani su nekovalentno, neki kovalentno putem esterske veze nestabilne u lužinama, a neki također kovalentno, ali putem GPI-sidra i beta-1,6-glukana. Za najzastupljeniji nekovalentno vezani protein, Scw4p, nađeno je da je na glukan djelomično vezan i kovalentno, još nepoznatom vrste veze. Jedan od ciljeva ovog projekta je objasniti molekularnu prirodu te veze. Osim toga, za nekoliko proteina stijenke, uključujući i Scw4p nađeno je da su proteolitički procesirani. Drugi cilj ovog projekta bio bi ispitati koje proteaze cijepaju Scw4p i koji je fiziološki značaj te modifikacije.Poznavanje mehanizama ugradnje proteina u stijenku kvasca upotrijebit će se za ugradnju i izlaganje na površini heterolognih proteina eksprimiranih u kvascu. Pripremit će se novi plazmidi u tu svrhu, za ekspresiju i ugradnju proteina u stijenku kvasaca S. cerevisiae i P. pastoris. Analizirat će se i stanične stijenke više drugih kvasaca izoliranih iz različitih habitata kako bi se ispitala mogućnost da oni budu novi domaćini za izlaganje proteina.Kako već postojeći, tako i novoistraženi genetički sustavi upotrijebit će se za izlaganje na površini šest enzima biokemijskog puta za degradaciju S-triazina iz bakterije Pseudomonas ADP. Istražit će se primjena dobivenih kvaščevih sojeva za degradaciju ovog široko korištenog herbicida.Druga potencijalna primjena ove metodologije obuhvatit će izlaganje nekoliko ksiloza reduktaza iz različitih kvasaca i primjenu dobivenih sojeva u proizvodnji ksilitola iz ksiloze uz odgovarajuću elektrokemijsku regeneraciju potrebnog NAD(P)H. Ispitat će se i potencijal te metode za primjenu u biosenzorima.]]></summary_hr><summary_en><![CDATA[Yeast cell wall consists of an inner layer of beta-1,3-glucan to which mannoproteins are attached. There is a pronounced variability among yeast cell wall proteins not only in their structures and activities, but also in the way they are incorporated into the wall. Some of them are attached non-covalently, some are linked covalently through an alkali labile ester linkage, and some are attached through GPI anchors and beta-1,6-glucan. The most abundant non-covalently attached protein Scw4p was found to be partly also covalently attached to glucan by a so far unknown linkage. One of the goals of this project is to explain the molecular nature of this linkage. Several cell wall proteins including Scw4p were found to be proteolytically processed. The second goal of the proposed project is to investigate which protease cleaves Scw4p and what is the physiological significance of this modification.Our comprehension of molecular mechanisms for incorporation of proteins in the yeast cell wall can be used for surface display of heterologous proteins expressed in yeasts. New plasmids will be created for this purpose for expression and wall incorporation of proteins in S. cerevisiae and P. pastoris. Besides, cell walls of several other non-Saccharomyces yeasts isolated from different habitats will be analysed to search for other potential hosts for surface display of proteins.Both existing, and newly investigated genetic systems will be used for surface display of six enzymes of the S-triazine complete degradation pathway from Pseudomonas ADP. Application of obtained strains in degradation of this world-wide commonly used herbicide will be explored. Described methodology would be used for surface display of several xylose reductases from several yeasts and the application of the obtained strains for enzymatic production of xylitol, combined with electrochemical regeneration of the necessary NAD(P)H. Potential of this method for application in biosensing will also be explored.]]></summary_en></project><project>
<id>3820</id><title_hr><![CDATA[Uloga ekonomskog sentimenta u tumačenju makroekonomskih trendova: metodološka unapređenja i nova područja primjene]]></title_hr><title_en><![CDATA[]]></title_en><user_id>4299</user_id><user_firstLast_name>Mirjana Čižmešija</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2015-10</proposal_call><code>DOK-2015-10-4697</code><acronim><![CDATA[MCPSIL2484BI]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Ekonomija, </scie_field_hr><scie_field_en>Economy, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Ekonomski fakultet u Zagrebu]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Economics and Business]]></institution_en><team_members_id>21201</team_members_id><team_members_names><![CDATA[ Doktorand: Marina Matošec ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[Business and Consumer Surveys, economic sentiment, leading indicators, behavioral economics, nonlinear econometrics]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[The aim of this project is to incorporate psychological sentiment (obtained by Business and Consumer Surveys; BCS) in macroeconomic modeling. Namely, BCS offer direct assessment of the otherwise intangible factors such as economic agents’ perceptions and expectations. They measure the agents’ willingness to consume/invest/save, as opposed to their ability to do the same. Hence these psychological factors are crucial to understand the underlying market forces and agents’ behavior. The project goals are to:- Discern whether the non-rationality of consumers’ inflation expectations stems from the true inability of consumers to anticipate price changes, or did the researchers induce it themselves by falsely assuming that the distribution of BCS responses is normal. - Question whether the poor forecasting accuracy of BCS leading indicators can be improved through obtaining the optimal weights by (non)linear optimization.- Compose an optimism indicator based on BCS responses and determine the nature of its relationship with the stock market returns. Nonlinear time series analysis will be employed to test if the stock market reacts asymmetrically to positive/negative shocks in the economic sentiment.- Estimate the consumers’ willingness to buy realty and econometrically model its relationship with actual real estate prices.- Assess the value of BCS responses on households’ financial distress by correlating them to the common measures of poverty.- Employ the BCS data on managers’ perceptions to construct a liquidity indicator for the Croatian economy.The first 5 goals will be fulfilled by analyzing the proposed issues in EU countries, which will improve the general understanding of the role of sentiment in economic decision-making. Each of the stated research fields is expected to result in the publication of a paper in a reputable international journal. The results empirically obtained for Croatia will be synthesized in a scientific book at the end of the project.]]></summary_en></project><project>
<id>3823</id><title_hr><![CDATA[Hrvatsko longitudinalno istraživanje dobrobiti]]></title_hr><title_en><![CDATA[]]></title_en><user_id>67</user_id><user_firstLast_name>Ljiljana Kaliterna Lipovčan</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2015-10</proposal_call><code>DOK-2015-10-2196</code><acronim><![CDATA[CRO-WELL]]></acronim><duration>02.01.2017 - 01.07.2021</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Psihologija, </scie_field_hr><scie_field_en>Psychology, </scie_field_en><institution_hr><![CDATA[Institut društvenih znanosti Ivo Pilar]]></institution_hr><institution_en><![CDATA[Institute of Social Sciences Ivo Pilar in Zagreb]]></institution_en><team_members_id>23199</team_members_id><team_members_names><![CDATA[ Doktorand: Lana Lučić ]]></team_members_names><keywords_hr><![CDATA[dobrobit, životni događaji, regulacija emocija, ličnost, longitudinalno istraživanje]]></keywords_hr><keywords_en><![CDATA[well-being, life events, affect regulation, personality, longitudinal study]]></keywords_en><summary_hr><![CDATA[Namjera nam je pokrenuti on-line longitudinalno istraživanje dobrobiti. Ovaj projekt ima dva cilja. Prvi cilj je provjeriti stupanj u kojem se dobrobit mijenja tijekom vremena i jesu li obrasci tih promjena različiti za ljudie različitih osobina. Drugi cilj je ispitati može li se dobrobit smatrati ne samo pokazateljem dobrog života, nego i nužnim dijelom povoljnih ishoda i pozitivnih životnih događaja, kao što je predloženo u teoriji proširenja i izgradnje pozitivnih emocija. Mi tvrdimo da visoke razine dobrobiti omogućavaju stvaranje kasnijih povoljnih životnih događaja i uvjeta za učinkovite strategije regulacije emocija. Tijekom razdoblja od četiri godine planiramo provesti on-line panel istraživanje u četiri vala. U istraživanju će biti korišten uzorak odraslih internet korisnika u Hrvatskoj. Bit će prikupljeni podaci o socio-demografskim varijablama, osobinama ličnosti, različitim sastavnicima dobrobiti, strategijama regulacije emocija i životnim događajima. U pilot testiranju bit će provedene fokus grupe u svrhu razvoja instrumenata. Kako bi privukli što je moguće više sudionika u istraživanje i smanjili osipanje tijekom provedbe uzastopnih valova istraživanja, puno će truda biti uloženo u promociju i oglašavanje projekta, kao i u informiranje i motiviranje sudionika da nastave sa sudjelovanjem u istraživanju. Praćenjem ljudi kroz duži period moći ćemo bolje objasniti povezanost između dobrobiti i životnih ishoda, kao i promjena u dobrobiti.]]></summary_hr><summary_en><![CDATA[We intend to launch on-line longitudinal research on well-being. The goal of the project is twofold. First, to examine the degree to which well-being fluctuates over time and whether patterns of well-being fluctuations are different for different types of people. Second, we aim to examine whether well-being can be considered not only as an indicator of good life, but also as a precondition of  positive outcomes and favourable life events, as proposed in the broaden-and-build theory of positive emotions. We posit that high levels of well-being enable the creation of later favourable life events and conditions by effective affect regulation strategies. During the four year project period, we plan to conduct on-line four-wave panel survey. Study sample will consist of adult internet users in Croatia. Through the survey, data on socio-demographic variables, personality traits, different components of well-being, affect regulation strategies and life events will be collected. Focus groups will be used as pilot tests to develop instruments. In order to recruit as many respondents as possible and to minimize attrition over the course of the consecutive waves lots of effort will be put into project promotion and advertising, as well as into informing and motivating participants to continue with the research. By following people through longer periods of time we would be able to better explain the relationships between well-being and life outcomes, as well as fluctuations in well-being.]]></summary_en></project><project>
<id>3826</id><title_hr><![CDATA[Hiperfosforilacija, agregacija i transsinaptički prijenos tau proteina u Alzheimerovoj bolesti: analiza likvora i ispitivanje potencijalnih neuroprotektivnih spojeva]]></title_hr><title_en><![CDATA[]]></title_en><user_id>11124</user_id><user_firstLast_name>Goran Šimić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2015-10</proposal_call><code>DOK-2015-10-7200</code><acronim><![CDATA[ALZTAUPROTECT]]></acronim><duration>09.11.2016 - 08.05.2022</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb School of Medicine]]></institution_en><team_members_id>22652</team_members_id><team_members_names><![CDATA[ Doktorand: Lea Langer Horvat ]]></team_members_names><keywords_hr><![CDATA[Alzheimerova bolest, cerebrospinalna tekućina (likvor), ELISA, neurofibrilarna degeneracija, neuroprotektivni spojevi, tau protein, tioflavin S ]]></keywords_hr><keywords_en><![CDATA[Alzheimer&#39;s disease, cerebrospinal fluid, ELISA, neurofibrillary degeneration, neuroprotective compounds, tau protein, thioflavine S]]></keywords_en><summary_hr><![CDATA[Za Alzheimerovu bolest (AB) ne postoji uzročno liječenje jer su brojni dosadašnji pokušaji intervencije temeljeni na amiloidnoj kaskadnoj hipotezi bili neuspješni. Usporedno s napretkom razumijevanja uloge tau proteina u patogenezi AB, metabolizam tau proteina je postao i važan terapijski cilj. Naime, smatra se da je u AB ravnoteža između kinaza i fosfataza tau proteina narušena, što dovodi do njegove hiperfosforilacije. Posljedično se povećava i frakcija tau proteina nevezanih za mikrotubule, pa se hiperfosforilirani tau monomeri vežu jedan za drugoga proizvodeći oligomere. Spajanje tau oligomera dovodi do oblikovanja sparenih uzvojitih filamenata, od kojih se sastoje sve neurofibrilarne promjene za koje je dokumentirano da predstavljaju najraniji neuropatološki događaj (tzv. &#39;&#39;pre-tangle&#39;&#39; stadij) od ključnog značaja za patogenezu AB. Ciljevi našeg projekta su: 1) bolje definirati odnos između bioloških biljega ranih stadija AB: ukupnih i fosforiliranih tau proteina, kao i amiloida ß u cerebrospinalnoj tekućini (likvoru) bolesnika s AD, MCI (blagi spoznajni poremećaj) i kontrolnih ispitanika. Uporabom inovativnog ELISA postupka i modificiranog eseja pomoću tioflavina S, u uzorcima likvora odrediti ćemo omjer između monomera i oligomera (agregata) tau proteina. Ti će novi podatci biti uspoređeni s kliničkim, neuropsihološkim i MRI nalazima; 2) testirati ćemo neke poznate i potencijalno neuroprotektivne spojeve (donepezil, klorgilin, nekoliko različitih flavonoida, te PF9601N i ASS234) na fosforilaciju tau proteina izazvanu okadaičnom kiselinom i nokodazolom u kulturama SH-SY5Y i P19 stanica. Epitope tau proteina fosforilirane na Thr181, Ser199 i Thr231 analizirati ćemo ELISA postupkom, a one na epitopima Thr202, Thr205, Ser396 i Ser404 pomoću westernske razložbe; i 3) istražiti ćemo biokemijski i imunocitokemijski transsinaptičko širenje neurofibrilarne degeneracije i razinu izraženosti tau mRNA nakon injekcije tau oligomera u entorinalnu moždanu koru miša.]]></summary_hr><summary_en><![CDATA[There is no effective treatment for Alzheimer’s disease (AD). As many drugs discovery attempts based on the amyloid cascade hypothesis have not been successful, tau protein has become an increasingly important therapeutic target owing to advances in understanding of its role in AD pathogenesis. In AD, the balance of tau kinase and phosphatase activity is shifted, creating a highly phosphorylated species of tau. This raises the fraction of unbound tau, which is no longer attached to microtubules, allowing for monomeric hyperphosphorylated tau to bind to one another to produce oligomers. Fusion of these oligomeric species leads to the formation of paired helical filaments, the primary constituent of neurofibrillary changes, which have been documented to be an early and pivotal event (so-called „pre-tangle“ stage) in the pathogenesis of AD. Our aims are: 1) to define better the relationship between the early AD biomarkers total and phospho-tau proteins, as well as amyloid ß in cerebrospinal fluid (CSF) of AD, MCI (mild cognitive impairment), and control subjects. By using innovative ELISA and modified thioflavin S binding assay on CSF samples, we will also assess the ratio between monomer and oligomer (aggregated) tau species. These new data will be correlated to clinical, neuropsychological, and MRI findings; 2) to test the effect of several known and potentially neuroprotective compounds (donepezil, clorgyline, several flavonoids, PF9601N and ASS234, among others) on tau phosphorylation induced by okadaic acid and nocodazole in SH-SY5Y and P19 cell cultures. Tau epitopes phosphorylated at Thr181, Ser199 and Thr231 residues will be analyzed by ELISA, while p-tau epitopes at Thr202, Thr205, Ser396 and Ser404 will be analyzed by Western blot; and 3) to investigate biochemically and immunocytochemically the trans-synaptic spreading of neurofibrillary degeneration and tau mRNA expression after the injection of tau oligomers in the mouse entorhinal cortex.]]></summary_en></project><project>
<id>3827</id><title_hr><![CDATA[Akrobacije molekulskih kristala - termoodskočni materijali za novu generaciju aktuatora]]></title_hr><title_en><![CDATA[]]></title_en><user_id>13189</user_id><user_firstLast_name>Željko Skoko</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2015-10</proposal_call><code>DOK-2015-10-7656</code><acronim><![CDATA[AKROBATOO MATER]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, </scie_field_hr><scie_field_en>Physics, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>23052</team_members_id><team_members_names><![CDATA[ Doktorand: Teodoro Klaser ]]></team_members_names><keywords_hr><![CDATA[termoodskočni efekt, aktuatori, strukturna analiza, rendgenska difrakcija, kvantnomehaničko modeliranje]]></keywords_hr><keywords_en><![CDATA[thermosalient effect, actuators, structure analysis, XRD, DFT calculations]]></keywords_en><summary_hr><![CDATA[Ciljano dizajniranje novih aktuatorskih materijala, koji su u stanju pružiti odgovor na vanjsku pobudu (toplinsku ili svjetlosnu) u obliku brzog, revezibilnog i kontroliranog mehaničkog kretanja trenutno predvodi istraživanja u znanosti o materijalima. Među takvim materijalima, nekoliko slučajno otkrivenih primjera kristala koji skaču za vrijeme grijanja, do daljina nekoliko tisuća puta većih od njihovih dimenzija u vremenu kraćem od 1 ms, pružaju impresivan prikaz pretvorbe toplinske energije u mehanički rad. Takvi termoodskočni (eng. thermosalient) kristali su biomimetički, nepolimerni samo-aktuatori par excellance. Ipak, zbog ekskluzivnosti ovog fenomena, i također zbog izuzetne složenosti analitičke metodologije za njegovu karakterizaciju, razlozi koji izazivaju ovu kolosalnu samo-aktuaciju ostaju nerazjašnjeni. Unutar projekta, odredit će se razlog postojanja termoodskočnog efekta u odabranim sustavima organskih molekulskih kristala (trans, trans, anti, trans, trans perhidropiren, L-piroglutamska kiselina te N’-2-propiliden-4-hidroski-benzohidrazid) koji su već poznati u literaturi, ali su još nerazjašnjeni. Nadalje, istraživanja će se proširiti na skupinu spojeva dobivenu odabranim i pažljivim modificiranjem spojeva za koje je efekt prethodno ustanovljen. Za očekivati je da će termoodskočni efekt biti izuzetno osjetljiv na suptilne promjene u kemijskom sastavu stoga će se omogućiti određivanje uvjeta za modeliranje novih materijala s termoodskočnim svojstvima. S ciljem elucidacije termoodskočnog fenomena, ovaj projekt predstavlja prvi sustavni pokušaj određivanje međuigre između termodinamičkih, kinematičkih, strukturnih i makroskopskih faktora termoodskočnog efekta pomoću difrakcijskih (XRD), mikroskopskih (hot-stage), spektroskopskih (FTIR, UV/VIS) i termičkih (DTA/DSC/TG) tehnika. Ispitivani sustavi također će se izučavati kvantomehaničkim modeliranjem (DFT). ]]></summary_hr><summary_en><![CDATA[Targeted design of new actuating materials which are capable of fast, reversible and controllable mechanical motion in response to external stimuli (thermal or light) is at the frontier of the contemporary materials science research. Among these, the few serendipitously discovered examples of crystals that suddenly jump while heated, to distances several thousand times larger than their own dimension in less than 1 ms, provide the most impressive display of the conversion of thermal energy into mechanical work. These thermosalient crystals are biomimetic, nonpolymeric self-actuators par excellence. Yet, due to exclusivity of the phenomenon, but also due to the complexity of analytical methods for its characterization, reasons behind this colossal self-actuation remain unexplained. Within this project, reasons behind the thermosalient effect in chosen systems of organic molecular crystals (trans,trans,anti,trans,trans perhydropyrene, L-pyroglutamic acid and N&#39;-2-propylidene-4-hydroxy-benzohydrazide), already reported in the literature – but unexplained, will be revealed. Furthermore, research will broaden to include a group of compounds obtained by careful and planned modification of the compounds in which the effect has already been observed. It is to be expected that the thermosalient effect is very sensitive to the subtle changes in the chemical composition so this will enable determination of necessary chemical/structural parameters so as to arouse the thermosalient effect in the system. With the aim of final elucidation of the thermosalient phenomenon, this project represents first systematic attempt to disentangle the interplay between the thermodynamic, kinematic, structural and macroscopic factors that drive the thermosalient effect by employing various diffraction (XRD), microscopic (hot stage), spectroscopic, (FTIR, UV/VIS) and thermal (DTA/DSC/TG) techniques. Systems under study will also be investigated by the means of quantomechanical modeling (DFT). ]]></summary_en></project><project>
<id>3828</id><title_hr><![CDATA[Razvoj višenamjenskog sustava upravljanja zemljištem]]></title_hr><title_en><![CDATA[]]></title_en><user_id>3172</user_id><user_firstLast_name>Vlado Cetl</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2015-10</proposal_call><code>DOK-2015-10-9505</code><acronim><![CDATA[DEMLAS]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Geodezija, </scie_field_hr><scie_field_en>Geodesy, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Geodetski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Geodesy]]></institution_en><team_members_id>21294</team_members_id><team_members_names><![CDATA[ Doktorand: Dragan Divjak ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[Land Administration System, Land Registers, Land Management, Sustainable Development, Geoinformation]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[The primary purpose of a land administration system (LAS) is the registration of legal or other formal relations of persons to land. Besides its primary purpose, land administration system can and should also serve as a basis for land management. Different to the land administration, land management is a set of processes ensuring that the land is used in an efficient and sustainable manner. Unfortunately, land administration systems are rarely able to fulfill such additional requirements, even in the developed countries.This project aims at finding what needs to be done in order to transform a traditional land administration system into a modern multipurpose land administration system (MLAS), which can efficiently support land management. Our hypothesis says that such a transformation can be done by improving two aspects of a LAS, its efficiency and its usability.Under efficiency we consider the ability of a LAS to update its data quickly whilst ensuring the consistency and correctness thereof. Within the project we will investigate options for outsourcing the preparation of transactions to private sector and the possibilities to more efficiently collect field data within the improved process of updating LAS data.Even more important that its efficiency, is the usability of a LAS. This is the second aspect that we try to improve within the project. Besides the mere registration of the land, MLAS must be able to efficiently support processes of land valuation, urban planning and various rearrangements aiming to increase agricultural productivity of the land. Within the project we will investigate which additional data needs to be collected, processed and stored within the LAS in order to enable efficient support to land management processes.As a starting point for the research we use our previous research closely related to the topics of land administration and land management, and the Land Administration Domain Model (LADM), which recently became the ISO standard.]]></summary_en></project><project>
<id>3830</id><title_hr><![CDATA[Mikrobna ekologija voda kao pokazatelj zdravstvenog stanja okoliša ]]></title_hr><title_en><![CDATA[]]></title_en><user_id>5800</user_id><user_firstLast_name>Damir Kapetanović</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2015-10</proposal_call><code>DOK-2015-10-4841</code><acronim><![CDATA[AQUAHEALTH ]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Veterinarska medicina, </scie_field_hr><scie_field_en>Veterinary medicine, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>21141</team_members_id><team_members_names><![CDATA[ Doktorand: Anamarija Kolda ]]></team_members_names><keywords_hr><![CDATA[bakterija, rezistencija, mikrobna ekologija, riba, kvaliteta vode, sediment, zdravlje ljudi]]></keywords_hr><keywords_en><![CDATA[bacteria, resistance, microbial ecology, fish, water quality, sediment, human health]]></keywords_en><summary_hr><![CDATA[Većina studija o mikrobnoj ekologiji vodenog okoliša usredotočena je na odvojene dijelove vodenog ekosustava. našim projektom predlažemo opsežnu studiju bakterijske zajednice u vodenom stupcu, sedimentu i ribama kao pokazateljima zdravstvenog stanja vodenog okoliša i njegovih mogućih implikacija na ljudsko zdravlje. Projektom se nastoji istražiti genetsku raznolikost bakterijskih izolata u vodenom okolišu, od površine do dna, odnose između izolata iz okoliša, onih iz zdravih riba i onih iz riba s kliničkim simptomima bolesti. Ovi podaci su neophodni za predviđanje nastanka i putova širenja bakterijskih pokazatelja kvalitete vode, kao i potencijalno patogenih bakterija, kako za ribe, tako i za ljude. Istražit će se profili rezistencije na antimikrobne lijekove, kako bi se utvrdilo potencijalnu vezu između odabranih modelnih bakterija i njihove rezistencije te učinak različitih uzročnika stresa iz okoliša. Cjelokupna strategija radnog plana je primijeniti multidisciplinarni pristup za istraživanje složenog bakterijskog ekosustava u vodenom okolišu (vidi Sliku 1). Unutar trenutnog partnerstva, četiri zadatka su identificirana, za rješavanje specifičnih problema u vezi s mikrobnom ekologijom vodenog okoliša: 1. Plan i obrazloženje uzorkovanja, 2. Ribe kao modelni organizmi, 3. Odabrane modelne bakterije i 4. Utjecaj na zdravlje ljudi. Istraživanje će se provesti korištenjem infrastrukture i stručnosti prisutne u okviru konzorcija. Projekt će okupiti state of the art istraživanja iz trenutno fragmentiranih područja. Ovo će stvoriti osnovu za daljnje djelovanje u prevenciji bolesti i poremećaja zdravlja riba zbog djelovanja uvjetno patogenih bakterija. Poboljšana održivost okoliša će poboljšati ukupnu ekonomsku održivost sektora akvakulture. To će biti od velikog interesa za širu javnost, proizvođače, potrošače riba i ribljih proizvoda, kao i kreatore i izvršitelje zakona.]]></summary_hr><summary_en><![CDATA[The majority of studies in aquatic microbial ecology focus on the separate segments of aquatic ecosystem. Our project proposes comprehensive study of bacterial community within water column, sediment and fish as indicator of the aquatic environmental health status and its potential implications to human health. The project seeks to understand the genetic diversity of bacterial isolates in the aquatic environment, the relationships between environmental isolates, those from the healthy fish and from fish with clinical symptoms. These data are necessary to predict the origin and spreading pathways of bacterial indicators of water quality, as well as potentially pathogenic bacteria, both for fish and humans. Antibiotic resistance profiles will be explored to determine a potential link between selected model bacteria and their resistance, and the effects of different environmental stress factors. The overall strategy of the work plan is to implement a multidisciplinary approach for the examination of the complex bacterial ecosystem in the aquatic environment. Within the partnership, four tasks have been identified, equating to resolving of specific problem connected with aquatic microbial ecology: 1. Sampling network design and rationale, 2. Fish as model organisms, 3. Selected Model Bacteria and 4. Impact on human health. Research will be carried out using the infrastructures and expertise present within the consortium. The project will bring together state of the art research from currently fragmented research fields in the same area. This will create a basis for further actions in the prevention of diseases and disorders in fish caused by potential pathogens. Improved environmental sustainability will enhance the overall economical viability of the aquaculture sectors, concerned with lowering environmental impacts resulting from current practices. This will be of high interest to the general public, fish consumers, policy makers and policy administrators.]]></summary_en></project><project>
<id>3832</id><title_hr><![CDATA[Primjena mikrosimulacijskih modela u analizi poreza i socijalnih naknada u Hrvatskoj]]></title_hr><title_en><![CDATA[]]></title_en><user_id>842</user_id><user_firstLast_name>Ivica Urban</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2015-10</proposal_call><code>DOK-2015-10-1733</code><acronim><![CDATA[AMMATSBC]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Ekonomija, </scie_field_hr><scie_field_en>Economy, </scie_field_en><institution_hr><![CDATA[Institut za javne financije]]></institution_hr><institution_en><![CDATA[Institute of Public Finance]]></institution_en><team_members_id>21291</team_members_id><team_members_names><![CDATA[ Doktorand: Martina Pezer ]]></team_members_names><keywords_hr><![CDATA[mikrosimulacije, modeli, porezi, socijalne naknade, EUROMOD, reforma, ponuda rada, zaposlenost, raspodjela dohotka, siromaštvo]]></keywords_hr><keywords_en><![CDATA[microsimulation, models, taxes, social benefits, EUROMOD, reform, labour supply, employment, income distribution, poverty]]></keywords_en><summary_hr><![CDATA[Mikrosimulacijski model poreza i socijalnih naknada (MSMPN) za svakog pojedinca iz skupa mikropodataka izračunava odgovarajuće iznose poreznih obveza i socijalnih naknada na koje osoba ima pravo. MSMPN omogućuje ex ante pregled učinaka promjena u sustavu poreza i socijalnih naknada i zbog toga je iznimno vrijedan alat u analizi i planiranju reforme.Za razliku od ostalih zemalja EU-a, gdje je uobičajena upotreba MSMPN-a, u Hrvatskoj je razvoj mikrosimulacijskih modela još uvijek u začetku.Zbog toga je svrha ovog projekta primijeniti mikrosimulacijske modele hrvatskih poreza i socijalnih naknada u analizama za potrebe vođenja javne politike i u akademskim analizama. Primjenom mikrosimulacijskih modela u analizi aktualnih ekonomsko-političkih problema ovaj projekt će pokazati korisnost mikrosimulacijskih modela te privući pozornost čelnika javne uprave i akademskih istraživača u Hrvatskoj.Istraživanje ima tri cilja:(1) Razviti mikrosimulacijski model hrvatskih poreza i naknada – miCROmod:miCROmod će biti konvencionalni statički aritmetički MSMPN koji simulira doprinose za socijalno osiguranje, porez na dohodak, zajamčenu minimalnu naknadu, doplatak za djecu, roditeljske naknade i naknadu za nezaposlene. Osim toga, razvit će se: (a) dodatak za jedinice lokalne vlasti, kojim se modeliraju porezi i socijalne naknade u Gradu Zagrebu, i (b) bihevioralni dodatak, koji će simulirati utjecaj promjena instrumenata poreza i socijalnih naknada na ponudu rada i na bruto plaće.(2) Upotrijebiti miCROmod i EUROMOD u analizi poreza i socijalnih naknada:miCROmod i EUROMOD (MSMPN za sve zemlje EU) koristit će se u analizi učinka raznih reformi na nejednakost u raspodjeli dohotka, stope siromaštva i poticaje za rad, a to su reforme: (a) Potpora za djecu, (b) Poreza na dohodak, (c) Instrumenata za povećanje isplativosti rada i (d) Lokalnih socijalnih naknada.(3) Predstaviti djelovanje mikrosimulacijskih modela čelnicima javne uprave i istraživačima.]]></summary_hr><summary_en><![CDATA[Microsimulation model of taxes and social benefits (MSMTBs) calculates for each individual person from a set of microdata the corresponding amounts of taxes payable and social benefits receivable. MSMTBs allow ex ante review of the effects of changes in tax-benefit system. Therefore, they are particularly valuable in the reform analysis and planning.Unlike in other EU countries, where the use of MSMTBs is widespread, the development of MSMTBs in Croatia is still in its infancy.Therefore, the purpose of this project is to apply microsimulation models of Croatian taxes and benefits in public policy and academic analysis. By application of MSMTBs in analysing contemporary economic and policy problems, the project will demonstrate the usefulness of these models, and attract the attention of public administration leaders (PALs) and researchers in Croatia.The research project has three objectives:(1) Develop the microsimulation model of Croatian taxes and benefits – miCROmod:miCROmod will be a conventional static arithmetic MSMTB that simulates social security contributions, personal income tax, guaranteed minimum income, child benefit, parental benefits and unemployment benefit. miCROmod will also include: (a) a local government supplement, modelling taxes and benefits in the City of Zagreb and (b) a behavioural supplement, simulating the impact of changes of tax-benefit instruments on the labour supply and gross wages.(2) Employ miCROmod and EUROMOD in the analysis of tax-benefit reform scenarios:miCROmod and EUROMOD (a comprehensive MSMTB for the EU) will then be used in the the analysis of the effect of a number of tax-benefit reforms on income inequality, poverty rates and incentives to work. These reforms cover: (a) Child benefits, (b) Personal income tax (c) In-work policies, and (d) Local social benefits.(3) Present the performance of miCROmod and EUROMOD to PALs and researchers.]]></summary_en></project><project>
<id>3835</id><title_hr><![CDATA[Divlja loza (Vitis vinifera subsp. sylvestris): vrijedan izvor gena za oplemenjivanje vinove loze]]></title_hr><title_en><![CDATA[]]></title_en><user_id>1507</user_id><user_firstLast_name>Goran Zdunić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2015-10</proposal_call><code>DOK-2015-10-4883</code><acronim><![CDATA[WI.GRA.GENE]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Poljoprivreda, </scie_field_hr><scie_field_en>Agriculture, </scie_field_en><institution_hr><![CDATA[Institut za jadranske kulture i melioraciju krša]]></institution_hr><institution_en><![CDATA[Institute for Adriatic Crops and Karst Reclamation in Split]]></institution_en><team_members_id>21312</team_members_id><team_members_names><![CDATA[ Doktorand: Katarina Lukšić ]]></team_members_names><keywords_hr><![CDATA[divlja loza, SSR markeri, domestikacija, ampelografija, genetika]]></keywords_hr><keywords_en><![CDATA[wild grape, SSR markers, domestication, amperlography, genetic]]></keywords_en><summary_hr><![CDATA[Divlja loza (Vitis vinifera subsp. sylvestris Gmel.) predak kultivirane vinove loze nikad nije detaljno istražena u Hrvatskoj. Prirodno stanište ove ugrožene europske biljke (prema IUCN Crvenoj listi ugroženih biljnih vrsta) je relativno netaknuta šuma u neposrednoj blizini vode. Genetska sličnost divlje i kultivirane loze je vrlo visoka (uključujući seksualnu kompatibilnost) iako divlja loza nije pretrpjela strog selekcijski proces domestifikacije. Dakle, tu postoje jedinstvene osobine i aleli još uvijek prisutni u genomu divlje loze, koje treba istražiti i koristiti u suvremenom cijepljenju vinove loze. Glavni ciljevi ovog projekta su i) procijeniti genetsku i fenotipsku raznolikost divlje loze u istraživanoj regiji i njihovu povezanost sa autohtonim sortama vinove loze u uzgoju, ii) sačuvati genetsku raznolikost, iii) istražiti neke morfološke i genetske karakteristike divlje loze koje su od posebnog interesa u programima cijepljenja i mogu pomoći u transferu određenih korisnih gena koji nisu bili cijenjeni tijekom domestifikacije i selekcije od strane ljudi jedinstven je doprinos ovog područja istraživanja. Ovaj projekt će omogučiti osnivanje genetskog laboratorija za DNA karakterizaciju vinove loze na IJK, okupljanje tima znanstvenika usmjerenih na divlju lozu omogućava multidisciplinarni uvid i povečanje vidljivosti i suradnje hrvatske istraživačke grupe sa međunarodnom znanstvenom zajednicom za lozne genetske resurse i istraživačku suradnju.]]></summary_hr><summary_en><![CDATA[The wild grapevine (Vitis vinifera subsp. sylvestris Gmel.) is an ancestor of cultivated grapevine and has never been explored in detail in Croatia. Natural native habitats for this endangered European plant (according to the IUCN Red list of threatened plant species) are relatively untouched forest with significant nearby water. The genetic similarity between wild and cultivated grapes is very high (including sexual compatibility) although the wild grape has not passed through the strict selection process of domestication. Thus, there are possible unique traits and alleles still present in the wild grape genome, which should be explored and used in modern grapevine breeding. The main objectives of this project are to i) assess the overall genetic and phenotypic diversity of wild grape in this region and their relatedness to local cultivated grapevine, ii) preserve the genetic diversity, iii) investigate some morphological and genetic characteristics of wild grape that are of special interest to breeding programs to aid transfer of certain beneficial genes that were not favoured during domestication and human selection bringing unique contribution to this research field. This project will enable the installation of a genetic laboratory for grapevine DNA characterization at the IAC, gather a team of scientists focused on wild grape to deliver multidisciplinary insight, and increase the visibility and collaboration of this Croatian research group with the international scientific community for grape genetic resources, and research collaboration.]]></summary_en></project><project>
<id>3837</id><title_hr><![CDATA[Genska tipizacija patogena prenosivih krpeljima analizom sekvenici više gena: popunjavanje praznina između životinjskih rezervoara, krpelja i ljudi]]></title_hr><title_en><![CDATA[]]></title_en><user_id>939</user_id><user_firstLast_name>Relja Beck</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2015-10</proposal_call><code>DOK-2015-10-7192</code><acronim><![CDATA[GENOTICKTRECK]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Veterinarska medicina, </scie_field_hr><scie_field_en>Veterinary medicine, </scie_field_en><institution_hr><![CDATA[Hrvatski veterinarski institut]]></institution_hr><institution_en><![CDATA[Croatian Veterinary Institute]]></institution_en><team_members_id>21270</team_members_id><team_members_names><![CDATA[ Doktorand: Daria Jurković ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[tick-borne pathogens, multilocus sequnce genotyping, pathogen distribution, animals, humans]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Globalization and climate change have an unprecedented worldwide impact on emergence and re-emergence of animal diseases, especially vector borne zoonoses.. Diseases that used to be limited only to tropical areas are now increasingly spreading to other previously unaffected regions. A wide variety of pathogens that can be propagated and transmitted by ticks infect humans, wildlife or domestic animals. Over the past decades, the scientific landscape of tick-borne diseases has changed significantly due to advances in molecular biology. Several new rickettsial and ehrlichial diseases, as well as new Borrelia and Babesia genotypes have been confirmed, and consequently, improved diagnostics of emerging diseases in veterinary and human medicine. A number of cases of tick-borne encephalitis (TBE) and Lyme disease have increased. To better understand the importance of tick-borne diseases, a proposed project follows an interdisciplinary approach involving physicians, veterinarians and biologists, also known as One Health approach. Since the cultivation of pathogens is difficult and slow, and for number of pathogens this cultivation is impossible, multylocus sequence typing MLST approach will be used for their genetic characterization of Babesia spp., Borrelia burgdorferi s. l., B. miyamotoi, Rickettsia spp., Anaplasma spp, Ehrlichia spp. Bartonella spp., Neoehrlichia mikurensis, Tick-borne encephalitis virus, Coxiella burnetii and Francisella tularensis from animal reservoirs, ticks and humans. Another objective will be to map tick species, since they were investigated 40 years ago, and to confirm species with PCR and sequencing. Application of genetic typing of multiple genes allows a detailed differentiation of genotypes and their heterogeneity. In this way, the genetic variability of the isolates, their geographical distribution and population genetic structure, as well as transmission routes of various isolates within ticks and their natural reservoirs, will be defined.]]></summary_en></project><project>
<id>3840</id><title_hr><![CDATA[Heuristička optimizacija u kriptologiji]]></title_hr><title_en><![CDATA[]]></title_en><user_id>6984</user_id><user_firstLast_name>Domagoj Jakobović</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2015-10</proposal_call><code>DOK-2015-10-2489</code><acronim><![CDATA[EvoCrypt]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Računarstvo, </scie_field_hr><scie_field_en>Computer sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id>22841</team_members_id><team_members_names><![CDATA[ Doktorand: Karlo Knežević ]]></team_members_names><keywords_hr><![CDATA[heuristička optimizacija, evolucijski algoritmi, kriptografija, kriptoanaliza, sklopovska izvedba]]></keywords_hr><keywords_en><![CDATA[heuristic optimzation, evolutionary computation, cryptography, cryptanalysis, hardware implementation]]></keywords_en><summary_hr><![CDATA[Cilj ovoga projekta je primjena stohastičkih i determinističkih algoritama optimizacije, kao i metoda strojnog učenja, na aktualnim problemima u kriptologiji. U okviru projekta istražit će se učinkovitost optimizacijskih algoritama, s naglaskom na evolucijsko računanje, primijenjenih na probleme oblikovanja nelinearnih elemenata za kriptografske algoritme, kao što su Booleove funkcije i S-kutije. Dio nastojanja bit će posvećen i optimizaciji sklopovske izvedbe tih elemenata, prije svega u kontekstu povećavanja propusnosti. Osim toga, prijedlog razmatra i problem učinkovitog traženja parametara napada umetanjem pogreške. Kako bi rezultati projekta bili dostupni široj zajednici, dodatna namjena projekta je stvaranje odgovarajuće programske potpore i optimizacijskih algoritama u obliku pratećeg skupa programskih alata, kako bi se omogućila primjena rezultata istraživačima u ovome području.]]></summary_hr><summary_en><![CDATA[This proposal aims at successful application of stochastic and deterministic optimization algorithms, as well as methods from the machine learning community, to current problems in cryptology. The project will investigate the efficiency of stochastic optimization algorithms, with evolutionary computation in particular, applied to the problems of creating nonlinear primitives for cryptography, such as Boolean functions and S-boxes. A part of this goal will also be devoted to optimization of hardware implementations of those primitives, primarily in the context of throughput maximization. Additionally, the proposal considers the problem of efficient search for parameters of successful fault analysis. The results of the project would not be easily attainable to the wider community without an appropriate collection of software tools for evaluation of candidate solutions to these problems and appropriate optimization algorithms. The final objective of this project is the creation of an accompanying open-source software tool collection to facilitate usage by researchers in the field.]]></summary_en></project><project>
<id>3842</id><title_hr><![CDATA[Kohortna studija rođenih na istočnojadranskim otocima]]></title_hr><title_en><![CDATA[]]></title_en><user_id>3126</user_id><user_firstLast_name>Saša Missoni</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2015-10</proposal_call><code>DOK-2015-10-4603</code><acronim><![CDATA[CRIBS]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Etnologija i antropologija, </scie_field_hr><scie_field_en>Ethnology and anthropology, </scie_field_en><institution_hr><![CDATA[Institut za antropologiju]]></institution_hr><institution_en><![CDATA[Institute for Anthropological Research]]></institution_en><team_members_id>24976</team_members_id><team_members_names><![CDATA[ Doktorand: Tonko Carić ]]></team_members_names><keywords_hr><![CDATA[metabolički sindrom, kohortna studija rođenih, rani razvoj, prevencija, čimbenici rizika]]></keywords_hr><keywords_en><![CDATA[metabolic syndrome, birth cohort, early development, prevention, risk factors]]></keywords_en><summary_hr><![CDATA[Metabolički sindrom (MetS) je vodeći uzrok obolijevanja i smrtnosti, s velikim utjecajem na zdravlje stanovništva i visokim troškovima liječenja. Njegova prevalencija je više od 30 % u općoj populaciji Hrvatske, uz posebno visoku stopu na hrvatskim otocima, do 58 %. Specifična obilježja istočnojadranskih otoka (genetički izolati s visokom razinom srođivanja, s miješanjem tradicionalnog i tranzicijskog životnog stila te stalnim depopulacijskim procesima) predstavljaju temelj za razvoj obrazaca čimbenika rizika koji utječu na pojavu MetS-a. Ovaj projekt je pilot-studija čiji su ciljevi: procijeniti prevalenciju poznatih čimbenika rizika (bioloških, ekoloških i ponašajnih) za razvoj MetS-a u ciljnim hrvatskim populacijama istočnojadranskih otoka i susjednog kopnenog područja te koristiti dobivene rezultate kao temelj za razvoj strategije intervencije. Populacijske kohortne studije trudnica i rođene djece su posebno pogodne za proučavanje ranih odrednica zdravlja i bolesti, koje se javljaju još u fetalnom razdoblju i djetinjstvu. Longitudinalni istraživački pristup će se primijeniti na reprezentativnom uzorku od 713 ispitanika u svakoj od dviju skupina: trudnica i njihove djeca u ciljnim populacijama otoka (Hvar, Brač i Vis) i susjednog kopnenog područja Splitsko-dalmatinske županije. Ishod projekta bit će otkrivanje skupova bitnih čimbenika rizika razvoja MetS-a u ciljnim populacijama. Dugoročni ishod je postupno razvijanje osnove djelotvorne strategije intervencije usmjerene na bitne čimbenike rizika nastanka MetS-a. Važnost nalaza ove pilot-studije je stvaranje temelja budućeg usmjerenijeg, populacijski prilagođenog modela rane intervencije, uključivanjem velikog broja bitnih čimbenika rizika za razvoj MetS-a, što će predstavljati značajan doprinos javnom zdravlju. Saznanja i iskustva stečena na temelju provedenih istraživanja doprinijet će stvaranju učinkovitijih programa promocije zdravlja, uzimajući u obzir utvrđene lokalne sociokulturne i okolišne specifičnosti.]]></summary_hr><summary_en><![CDATA[Metabolic syndrome (MetS) is the leading cause of high morbidity and mortality, with enormous impact on population health and medical costs. Its prevalence is more than 30% in the general Croatian population, with especially high rate on Croatian islands, up to 58%. Specific features of the Eastern Adriatic Islands (EAI) (genetic isolates with high level of inbreeding, mixing traditional and transitional lifestyle and continuous depopulation processes) represent a basis for development of specific MetS risk factor patterns. This project is a pilot study with the aims to: assess the prevalence of known risk factors (biological, environmental and behavioral) for the MetS in EAI and nearby mainland area of the targeted Croatian populations and to use this information as a base to develop an intervention strategy. Population-based pregnancy and birth cohort studies are particularly salient for studying early origins of health and disease that begin in fetal life and infancy. A longitudinal approach will be used on a representative sample of 713 participants in each group: pregnant women and children in the targeted populations of the islands (Hvar, Brač and Vis) and nearby mainland area of of the Split-Dalmatia County. The outcome of the project is revealing sets of relevant risk factors for the development of MetS in the studied Croatian populations. The long-term outcome is progressive development of a base for an effective intervention strategy, directed at relevant risk factors for MetS. The importance of this pilot study is developing foundations for a better focused population adjusted model of early intervention in the future. It will include a large number of relevant risk factors for MetS, which will contribute to beneficial public health outcomes. Knowledge and experiences, acquired in this research will contribute to the creation of programs for health promotion, taking into account local socio-cultural and environmental characteristics.]]></summary_en></project><project>
<id>3846</id><title_hr><![CDATA[Safe human-robot interaction in logistic applications for highly flexible warehouses (SafeLog)]]></title_hr><title_en><![CDATA[]]></title_en><user_id>378</user_id><user_firstLast_name>Ivan Petrović</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2015-10</proposal_call><code>DOK-2015-10-8551</code><acronim><![CDATA[]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Temeljne tehničke znanosti, </scie_field_hr><scie_field_en>Basic engineering sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id>25415</team_members_id><team_members_names><![CDATA[ Doktorand: Goran Popović ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>3847</id><title_hr><![CDATA[Kinetochore oscillations in mitotic metaphase]]></title_hr><title_en><![CDATA[]]></title_en><user_id>6276</user_id><user_firstLast_name>Nenad Pavin</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2015-10</proposal_call><code>DOK-2015-10-5291</code><acronim><![CDATA[]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, </scie_field_hr><scie_field_en>Physics, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>22681</team_members_id><team_members_names><![CDATA[ Doktorand: Agneza Bosilj ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>3848</id><title_hr><![CDATA[Potencijali i prepreke razvoja socijalnih supermarketa u Srednjoj i istočnoj Europi]]></title_hr><title_en><![CDATA[]]></title_en><user_id>11297</user_id><user_firstLast_name>Blaženka Knežević</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2015-10</proposal_call><code>DOK-2015-10-9303</code><acronim><![CDATA[SSMCEE]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Ekonomija, </scie_field_hr><scie_field_en>Economy, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Ekonomski fakultet u Zagrebu]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Economics and Business]]></institution_en><team_members_id>13029</team_members_id><team_members_names><![CDATA[ Doktorand: Petra Škrobot ]]></team_members_names><keywords_hr><![CDATA[maloprodaja, oblici maloprodaje, društvena odgovornost, socijalni supermarketi, socijalne inovacije]]></keywords_hr><keywords_en><![CDATA[retailing, retail formats, social responsibility, social supermarkets, social innovations]]></keywords_en><summary_hr><![CDATA[Ekonomska kriza uzrokovala je porast nezaposlenosti i povećanje siromaštva u Europskoj uniji. S druge strane, tradicionalni kanali distribucije obično stvaraju viškove koji se mogu učinkovitije iskoristiti. Istraživanja pokazuju da socijalne samoposluge, kao novi maloprodajni oblik, postaju sve važniji čimbenik u smanjenju siromaštva u cijeloj Europi putem učinkovitije raspodjele stvorenih viškova roba. Socijalne samoposluge po svojoj osnovnoj svrsi i načinu poslovanja, značajno se  razlikuju u odnosu na tradicionalne maloprodajne oblike, a u postojećoj znanstvenoj literaturi još uvijek nisu istražene u dovoljnoj mjeri, posebice u zemljama Srednje i istočne Europe. Kako socijalne samoposluge temelje svoje djelovanje na filantropskim osnovama, volontiranju i donacijama, a već na nekim tržištima značajno utječu na strukturu prihoda tradicionalnih maloprodavača, ova tema zahtijeva multidisciplinarni pristup kako bi se: (a) pojasnila njihova trenutna pozicija i njihov utjecaj na opću socio-ekonomsku situaciju na pojedinim tržištima, (b) istražio pravni okvir koji je utemeljen u onim zemljama u kojima su socijalni supermarketi postigli visok stupanj razvoja, posebno u području poreznog zakonodavstva i zakonodavstva prava potrošača, (c) istaknula pitanja upravljanja u vezi organizacije rada volontera ili zaposlenika, i (d) objasnili specifični problemi učinkovite organizacije ulazne logistike te distribucije roba i usluga unutar socijalnih supermarketa. Zato će projektni tim obuhvatiti stručnjake iz područja trgovine, upravljanja maloprodajom, upravljanja neprofitnim organizacijama, korporativnih financija, fiskalnih sustava i socijalnog rada iz nekoliko znanstvenih institucija iz četiri države Srednje i istočne Europe.]]></summary_hr><summary_en><![CDATA[The ongoing economic crisis caused the rising unemployment and the increasing poverty in the European Union. On the other hand, the traditional distribution channels usually generate surpluses that can be effectively used to decrease problems of poverty. Research studies show that Social supermarkets, as a new retail, are becoming increasingly important factor in reducing poverty across Europe throughout more efficient distribution of generated surpluses of goods. Social supermarkets at their core purpose and mean of operations are substantially different compared to the traditional retail formats, and in the current scientific literature they have not been sufficiently investigated so far, especially in Central and Eastern European countries. As social supermarkets base their operation on philanthropic foundations, volunteering and donations, and already in some markets significantly affect the structure of revenues of the traditional retailers, this topic requires a multidisciplinary approach in order: (a) to clarify their current position and their impact the general socio-economic situation in the particular markets, (b) to investigate the legal framework that has been established by those countries in which social supermarkets reached a high level of development, particularly in the area of tax legislation and consumer rights legislation, (c) to assess management issues regarding work organization of volunteers or employees, and (d) to explain particular problems of the effective organization of input logistics and distribution of goods and services within social supermarkets. Therefore, the project team will include experts from the fields of retailing, retail management, management of nonprofit organizations, corporate finance, fiscal systems and social work from several scientific institutions from four Central and Eastern European countries.]]></summary_en></project><project>
<id>3851</id><title_hr><![CDATA[Razumijevanje, praćenje i analiziranje transparentnosti proračuna lokalnih jedinica: Primjer Hrvatske i Slovenije - Indeks otvorenosti lokalnih proračuna]]></title_hr><title_en><![CDATA[]]></title_en><user_id>13372</user_id><user_firstLast_name>Katarina Ott</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2015-10</proposal_call><code>DOK-2015-10-8730</code><acronim><![CDATA[OLBI]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Ekonomija, </scie_field_hr><scie_field_en>Economy, </scie_field_en><institution_hr><![CDATA[Institut za javne financije]]></institution_hr><institution_en><![CDATA[Institute of Public Finance]]></institution_en><team_members_id>21290</team_members_id><team_members_names><![CDATA[ Doktorand: Branko Stanić ]]></team_members_names><keywords_hr><![CDATA[Local government, budget transparency, Open local budget index, Croatia, Slovenia]]></keywords_hr><keywords_en><![CDATA[lokalne jedinice, transparetnost proračuna, Indeks otvorenosti lokalnih proračuna, Hrvatska, Slovenija]]></keywords_en><summary_hr><![CDATA[Transparentnost proračuna lokalnih jedinica (TPLJ) od iznimne je važnosti budući da odluke lokalnih vlasti o trošenju javnih sredstava utječu na svakog građanina.  TPLJ označava u kojoj mjeri i koliko jednostavno građani mogu pristupati informacijama o prihodima i rashodima lokalnih proračuna. Transparentnost proračuna prvi je korak prema demokratizaciji proračunskog procesa i uključivanju građana u oblikovanje politika  i raspodjelu sredstava. Netransparentan proračun ne može se valjano analizirati, njegova se provedba ne može u potpunosti pratiti, niti se mogu vrednovati njegovi ishodi. Unatoč važnosti TPLJ-a, rijetka su istraživanja o njenim mjerenjima, uzrocima i posljedicama. Naš cilj je popuniti tu prazninu u literaturi istražujući: TPLJ u Hrvatskoj i Sloveniji, način na koji se ona mijenja tijekom vremena i razloge zbog kojih su neki lokalni proračuni transparentniji od drugih. Također ćemo nastojati odgovoriti na pitanja utječe li TPLJ na proračunske ishode u izbornim godinama, djeluje li na izborne rezultate i utječu li promjene TPLJ-a tijekom vremena na preferencije političara na vlasti i glasača u vezi s proračunskim ishodima. Oslanjajući se na postojeću literaturu i naše prijašnje radove, cilj nam je postaviti temelj za buduće istraživanje TPLJ-a, čiji će rezultat biti Indeks otvorenosti lokalnih proračuna (IOLP). Najprije ćemo uskladiti i prilagoditi već postojeću hrvatsku metodologiju (Ott, Bronić i Petrušić, 2013.; 2014.), kako bi se  mogla kontinuirano i na isti način primjenjivati na godišnjoj razini u Hrvatskoj i Sloveniji. Budući da će ovo  biti prvi put da se empirijski mjeri i prati TPLJ za prilično dugo razdoblje u dvije zemlje i budući da osim našeg rada (Ott, Bronić i Petrušić, 2013, 2014) nismo uspjeli naći niti jedan drugi rad o uzrocima i posljedicama TPLJ, naš kontinuirani projekt  će predstavljati jedinstven doprinos literaturi. Omogućit ćemo i donošenje boljih politika te veće sudjelovanje građana u odlučivanju o lokalnim proračunima. ]]></summary_hr><summary_en><![CDATA[Local government budget transparency (LBT) is of extreme importance as local authorities’ decisions upon spending public money have an impact on each and every citizen. LBT refers to how easily and to what extent citizens can access information on local government revenues and expenditures. Transparent budgets are a first step toward democratizing the budget process and giving citizens a say in policy formulation and resource allocation. A non-transparent budget cannot be properly analysed, its implementation cannot be thoroughly monitored nor can its outcomes be evaluated. Despite the importance of LBT, research into its measures, causes and consequences is thin. Our aim is to fill this literature gap and investigate: LBT in Croatia and Slovenia, how it changes over time and why some local budgets are more transparent than others. We will also try to answer: whether LBT affects budget outcomes in election years; whether it affects election outcomes and whether its changes over time influence incumbents&#39; and voters’ preferences regarding budget outcomes. Building upon the existing literature and our previous works, the aim is to construct the basis for future research into LBT, resulting in an open local budget index (OLBI). We will first harmonize and adapt the already existing Croatian methodology (Ott, Bronić and Petrušić, 2013; 2014) so that it can be further continually, annually applied in the same way in Croatia and Slovenia. Since this will be the first time that LBT will be empirically measured and monitored for a fairly long period of time in two countries, and since except for our own work (Ott, Bronić and Petrušić, 2013; 2014) we could find no other papers dealing with the causes and consequences of LBT, our continuous research will represent a unique contribution to the existing literature. Our results will also enable better policy-making and greater citizens’ participation in local budget deliberations.  ]]></summary_en></project><project>
<id>3853</id><title_hr><![CDATA[Ekonomske teškoće obitelji, psihosocijalni problemi i obrazovni ishodi adolescenata u vrijeme ekonomske krize]]></title_hr><title_en><![CDATA[]]></title_en><user_id>13038</user_id><user_firstLast_name>Marina Ajduković</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2015-10</proposal_call><code>DOK-2015-10-9088</code><acronim><![CDATA[FEHAP]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Socijalne djelatnosti, </scie_field_hr><scie_field_en>Social work, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Pravni fakultet u Zagrebu]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Law]]></institution_en><team_members_id>18962</team_members_id><team_members_names><![CDATA[ Doktorand: Ines Rezo ]]></team_members_names><keywords_hr><![CDATA[adolescenti,ekonomske teškoće obitelji,rizik siromaštva,eksternalizirani problemi,internalizirani problemi,rizična ponašanja,napuštanje školovanja]]></keywords_hr><keywords_en><![CDATA[adolescents, family economic hardship, risk of poverty, externalized problems, internalized problems, risk behaviours, dropping out of school]]></keywords_en><summary_hr><![CDATA[Cilj projekta je povećati razumijevanje učinaka ekonomskih teškoća obitelji na psihosocijalne i obrazovne probleme adolescenata u vrijeme nacionalne ekonomske krize. Novi integrativni model utjecaja ekonomskih poteškoća obitelji na razvoj adolescenta (IMEPO) će biti provjeren kroz longitudinalni kvantitativni i kvalitativni nacrt istraživanja. Istraživački problemi su: (1) Procijeniti ukupni i individualni doprinos prediktora u IMEPO na psihosocijalni razvoj adolescenata, gdje su kriteriji internalizirani i eksternalizirani problemi, druga rizična ponašanja (konzumacija alkohola i droga, kockanje i rizične seksualne aktivnosti) i obrazovni ishodi, uključujući napuštanje obrazovanja, (2) Usporediti uspješnost dva modela – osnovnog modela financijskog stresa (FSM) i novog IMEPO – u predviđanju psihosocijalnih i obrazovnih problema u razvoju mladića i djevojaka, (3) Utvrditi potencijalne rizične i zaštitne čimbenike koji moderiraju odnos između ekonomskih poteškoća obitelji i psihosocijalnih problema adolescenata te njihovih obrazovnih ishoda, (4) Ispitati promjene psihosocijalnih rizika i problema u školskom postignuću tijekom adolescencije, (5) Ispitati obrasce ranog napuštanja srednjoškolskog obrazovanja te steći dublje razumijevanje procesa i čimbenika koji vode ka napuštanju srednje škole.Učenike će se pratiti u tri točke mjerenja (I, II i III razred). Koristiti će se dvo-etapni neproporcionalno stratificirani klaster uzorak koji će obuhvatiti približno 1200 srednjoškolaca i njihovih majki/skrbnica. Istraživanje će se provesti u 6 županija središnje Hrvatske različitog ekonomskog statusa. Metodom namjernog uzorka bit će odabrano 40 učenika iz početnog uzorka koji su u promatranom razdoblju napustili srednjoškolsko obrazovanje. Ishodi projekta će se moći iskoristiti za daljnje razvijanje mjera socijalne i obiteljske politike usmjerenih prema smanjivanju negativnih učinaka ekonomskih teškoća na obitelji, obiteljske odnose i probleme prilagodbe adolescenata.]]></summary_hr><summary_en><![CDATA[Aim of the project is to advance the understanding of effects of family economic hardship on adolescents’ psychosocial and educational problems at a time of a nationwide economic crisis. A new integrative model of impact of family economic hardship (IMFEH) will be tested in a longitudinal quantitative and qualitative research design. The objectives are: (1) To assess the overall and individual contribution of predictors in IMFEH on adolescents&#39; psychosocial development, where internalized problems, externalized problems, other risk behaviours (alcohol and drug abuse, gambling, risk sexual behaviours) and educational outcomes, including dropp-out, will serve as criterion variables, (2) To compare the efficiency of two models – initial family stress model (FSM) and new IMFEH – in predicting psychosocial and educational problems in the development of male and female adolescents, (3) To identify potential risk and protective factors that moderate the relationship between family economic hardship and adolescents&#39; psychosocial problems and educational outcomes, (4) To investigate the changes in psychosocial risks and school achievement problems during adolescence, and (5) To explore patterns of early leaving secondary education and gain deeper understanding of the process and factors that lead to dropping out of secondary school. Pupils will be followed through 3 waves of data collection (1st, 2nd and 3rd grade). A two-stage disproportionally stratified cluster sample, which will include approximately 1200 pupils and their female caretakers, will be used. The research will be conducted in 6 counties that differ in economic development. 40 adolescents from the initial sample who have dropped out of school during the duration of the study will be recruited. The outcomes of the project will be used to advance the social and family policy measures aimed at reducing the negative effects of family economic hardship on family relations and adolescent adjustment problems.]]></summary_en></project><project>
<id>3858</id><title_hr><![CDATA[Napredna metodologija projektiranja prekidačkih istosmjernih pretvornika]]></title_hr><title_en><![CDATA[]]></title_en><user_id>7714</user_id><user_firstLast_name>Adrijan Barić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2015-10</proposal_call><code>DOK-2015-10-6509</code><acronim><![CDATA[AdvaDCDC]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Elektrotehnika, </scie_field_hr><scie_field_en>Electrical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id>22621</team_members_id><team_members_names><![CDATA[ Doktorand: Hrvoje Štimac ]]></team_members_names><keywords_hr><![CDATA[projektiranje integriranih sklopova, istosmjerni pretvornici, elektronički  sklopovi snage, galij-nitrid tranzistori, electromag. kompatibilnost]]></keywords_hr><keywords_en><![CDATA[integrated circuit design, DC-DC converters, power electronics, GaN transistors, electromagnetic compatibility]]></keywords_en><summary_hr><![CDATA[Napredna metodologija projektiranja prekidačkih istosmjernih pretvornika razvijena je u ovom projektu. Gornja sklopka, donja sklopa, pobudni i upravljački sklopovi integrirani su u jednom pakiranju, što minimizira utjecaj parazitnih elemenata i omogućava prekapčanja do 10 MHz. Razvit će se pobudni sklop s visokopreciznom kontrolom signala gornje i donje sklopke, što će omogućiti optimiranje mrtvog vremena s obzirom na efikasnost pretvaranja i smanjenje gubitaka za bilo koju kombinaciju parametara pakiranja integriranog sklopa, vanjskih komponenata i tiskane pločice. Posebna je pažnja posvećena projektiranju sklopa za pomak istosmjernog nivoa gornje sklopke. Osim što služi kao pobudni sklop za sklopke velike struje koje se nalaze na čipu, razvijeni pobudni sklop pobuđuje i vanjske pinove integriranog sklopa kako bi omogućio korištenje vanjskih sklopki. Galij-nitrid (GaN) i silicij-karbid (SiC) poluvodički elementi predstavljaju obećavajuće rješenje za visokonaponske i visokoefikasne pretvornike. Istosmjerni pretvornici koji koriste GaN/SiC tranzistore mogu se optimirati korištenjem prethodno razvijenog pobudnog sklopa. Razvijena metodologija omogućit će evaluaciju efikasnosti GaN i SiC elemenata u visokonaponskim prekidačkim primjenama kao i projektiranje kvalitetno optimiranih pretvornika. Tiskana pločica na koju je zalemljen čip pretvornika predstavlja sljedeći ključni dio dizajna pretvornika i ima dominantni utjecaj na određivanje elektromagnetske kompatibilnosti i termičkih svojstava pretvornika. Razvit će se simulacijsko okruženje koje omogućava elektromagnetsko-termičku kosimulaciju istosmjernih pretvornika. Provest će se statistička analiza parametara tiskane pločice i pakiranja integriranog sklopa kako bi se osiguralo da varijacije u proizvodnji ne narušavaju pouzdanost i efikasnost projektiranih pretvornika. ]]></summary_hr><summary_en><![CDATA[Advanced design methodology for switching DC-DC converters is developed. The low-side and high-side switch, their drivers and the control circuitry are integrated into one package which minimizes the parasitic elements and allows switching frequencies up to 10 MHz. A driving-signal circuitry with high-precision adjustable timings is developed. This will allow the optimisation of dead-times with respect to the power conversion efficiency of a converter for any given set of the parameters of the integrated circuit (IC) package, external components and a printed circuit board (PCB). A special attention is given to the design of a level-shifter for a high-side switch. Besides driving the on-chip power switches, the developed driving signal circuitry is routed to external pins of the IC package to enable driving of the externally connected switches. Gallium-nitride (GaN) and silicon-carbide (SiC) semiconductor devices present a promising solution for a high-voltage and high-efficiency power conversion. In order to design a highly efficient converter for high-voltage switching applications by using GaN and SiC power transistors, the GaN/SiC DC-DC converter will be optimised by using adjustable driving-signal circuitry, which is designed at the beginning of the project. The developed methodology will allow the evaluation of the efficiency of the GaN and SiC devices in high-voltage switching applications as well as highly optimised design of the converters. The PCB makes a large part of the design and it has a dominant effect in determination of the electromagnetic compatibility and thermal properties of the converter. A simulation environment which will allow the electromagnetic-thermal co-optimisation of DC-DC converters will be developed. A statistical analysis of the parameters of a PCB and an IC package will be performed to ensure that the variations in the manufacturing process do not compromise the reliability and the efficiency of the designed converters.]]></summary_en></project><project>
<id>3862</id><title_hr><![CDATA[Modeliranje toka podzemnih voda u krškim vodonosnicima]]></title_hr><title_en><![CDATA[]]></title_en><user_id>6169</user_id><user_firstLast_name>Vedrana Kozulić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2015-10</proposal_call><code>DOK-2015-10-2187</code><acronim><![CDATA[Karst modelling]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Građevinarstvo, </scie_field_hr><scie_field_en>Civil engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Splitu Fakultet građevinarstva, arhitekture i geodezije]]></institution_hr><institution_en><![CDATA[University of Split, Faculty of Civil Engineering, Architecture and Geodesy]]></institution_en><team_members_id>21318</team_members_id><team_members_names><![CDATA[ Doktorand: Grgo Kamber ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[karst aquifers, groundwater flow modeling, multiresolution and multiscale approach, karst heterogeneity, distributive karst models]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Karst aquifers are very important groundwater resources around the world as well as in coastal part of Croatia. They consist of extremely complex structure defining by triple phases: slow porous medium, mostly laminar fractures and usually fast turbulent conduits/karst channels. Usually, karst aquifers have been analyzed by lumped hydrological models which ignore high heterogeneity of karst and consider only input (precipitation) and output (spring discharge) due to lack of extensive other input data and knowledge regarding the karst system. Last two decades full hydraulic (distributive) models have been developed exclusively by conventional finite elements considering karst heterogeneity structure that improves our understanding of complex processes in karst. Therefore, in this project we will develop novel “unique” flow model based on multi-resolution approach originally designed by Gotovac et al. (2007-2013) for 1-D and 2-D groundwater flow and transport simulations. Proposed approach is based on Fup basis functions with compact support and meshless collocation procedure enabling multi-scale representation of heterogeneity and other flow variables, closely related to the karst flow physical interpretation. Moreover, extending existing procedure to 3-D and constructing separate multi-scale solution for all three karst phases, proposed approach will enable the following impacts in comparison to conventional methods: desired spatial and temporal accuracy and high computational efficiency, modular model structure, incorporation of different heterogeneity scales related to existing measurements, enabling of transport and tracer test analysis and better understanding of karst aquifers due to solving of different engineering problems such as water usage and protection or contaminant pollution. Flow model will be verified by laboratory experiments and numerical synthetic benchmarks as well as real examples such as Jadro catchment and Ombla underground accumulation.]]></summary_en></project><project>
<id>3863</id><title_hr><![CDATA[Programski sustav za paralelnu analizu više heterogenih nizova vremenskih podataka s primjenom u biomedicini]]></title_hr><title_en><![CDATA[]]></title_en><user_id>18915</user_id><user_firstLast_name>Mario Cifrek</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2015-10</proposal_call><code>DOK-2015-10-7975</code><acronim><![CDATA[]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Elektrotehnika, </scie_field_hr><scie_field_en>Electrical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id>21274</team_members_id><team_members_names><![CDATA[ Doktorand: Krešimir Friganović ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>3864</id><title_hr><![CDATA[Subplate zona ljudskog mozga: neriješeni problemi]]></title_hr><title_en><![CDATA[]]></title_en><user_id>12951</user_id><user_firstLast_name>Ivica  Kostović</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2015-10</proposal_call><code>DOK-2015-10-2341</code><acronim><![CDATA[HUMANSUBPLATE]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Hrvatska akademija znanosti i umjetnosti]]></institution_hr><institution_en><![CDATA[Croatian Academy of Sciences and Arts]]></institution_en><team_members_id>22457</team_members_id><team_members_names><![CDATA[ Doktorand: Iris Žunić Išasegi  ]]></team_members_names><keywords_hr><![CDATA[subplate, prematurus, vulnerabilnost, moždana kora, razvitak]]></keywords_hr><keywords_en><![CDATA[subplate, preterm infant, vulnerability, cortex, development]]></keywords_en><summary_hr><![CDATA[Subplate zona je najistaknutiji i najvoluminozniji arhitektonski odjeljak stijenke telencefalona u mozgu čovjeka, s ključnom ulogom u razvoju neuronskih veza moždane kore. Istraživanja su pokazala da ta zona ima rano razvojno porijeklo, sadrži brojne sinapse i neurone složenih citoloških svojstava i molekularne raznovrsnosti, uključena je u razvoj aferentnih aksona iz talamusa, kao i uspostavu privremenih neuronskih veza, prolaznu ekspresiju neurotransmitera, neuronskih krugova moždane kore i njihovu funkcionalnu specifikaciju, evoluciju moždane kore te patogenezu neuroloških, kognitivnih i mentalnih poremećaja. Brojna pitanja bitna za humanu razvojnu neurobiologiju ostala su neriješena: Kako se subplate povećava tijekom trudnoće? Kakva je sublaminarna, sinaptička, neuronalna i glijalna organizacija? Kakva je uloga u migraciji neurona? Kakvi su odnosi subplatea s dugim asocijativnim kortiko-kortikalnim vezama? Kakva je postnatalna sudbina? Postoji li selektivna vulnerabilnost subplate neurona i različitih klasa aksona i kako to prikazati u in vivo MRI? Naša je hipoteza da će veličina, karakteristični neuralni sadržaj i produljeni razvitak zajedno s karakterističnim svojstvima na MRI omogućiti prikaz onih karakterističnih osobina ljudskog subplatea koje su povezane sa složenošću kortikalnih veza. Specifični ciljevi su određeni da odgovore na gore navedena pitanja, primjenom histoloških, imunocitokemijskih i in vitro, in utero te in vivo MRI tehnika u mozgu čovjeka, kao i usporedbom tih podataka s nalazima u majmuna tretiranih s H3-Thymidine markerom replikacije DNA (Rakic, Yale). Rezultati ovog projekta će omogućiti bolji uvid u razvitak osjetljivog mozga fetusa i prijevremeno rođene djece, proširiti normativne podatke za pedijatrijski neuroimaging i studije praćenja koje su usmjerene na razvoj kortikalnih veza, te omogućiti dobre polazne osnove za istraživanje neuroloških, kognitivnih i mentalnih poremećaja, koji imaju utjecaj na društvo. ]]></summary_hr><summary_en><![CDATA[Subplate zone is the most prominent and voluminous, connectivity related, compartment of the cerebral wall of developing primate brain playing different developmental roles. Studies of this enigmatic neuronal compartment in human brain and experimental models have demonstrated early origin, synapse-rich content, complex cytology and molecular diversity, involvement in growth of thalamo-cortical fibres, transient connectivity and transmitter expression, functional specificity, role in formation of cortical circuitry, evolutional significance and prospective role in pathogenesis of neurological, cognitive and mental disorders. Review of the current literature indicate gaps in the our knowledge and existence of unsolved problems regarding secondary expansion of subplate, sublaminar distribution of synapses and different phenotypes of migratory and postmigratory neurons, transformation of radial glia, pattern of growth of long associative cortico-cortical pathways and vulnerability of subplate (axons, neurons and glia in preterm infant). It is our hypothesis that size characteristic neuronal content and prolonged development, together with MR imaging properties, will facilitate demonstration of those characteristic features of the human (primate subplate), which are related to the complexity of cortical connectivity. In this project, we will use histological, immunocytochemical and MR imaging techniques (in vitro and in vivo) for developing human brain, as well as comparative analysis of experimental non-human primate (provided by dr. Rakic, Yale) in order to give answers for unsolved problems in human SP neurobiology. We expect to demonstrate characteristic features of the human subplate related to complex cortical connectivity, develop new diagnostic criteria for MR imaging and follow-up of perinatally damaged brain and define novel normative data necessary for study of developmental neurological, cognitive and mental disorders, which have severe impact on society.]]></summary_en></project><project>
<id>3865</id><title_hr><![CDATA[Razvoj naprednih visokonaponskih sustava primjenom novih informacijskih i komunikacijskih tehnologija]]></title_hr><title_en><![CDATA[]]></title_en><user_id>5632</user_id><user_firstLast_name>IVO UGLEŠIĆ</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2015-10</proposal_call><code>DOK-2015-10-5442</code><acronim><![CDATA[DAHVAT]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Elektrotehnika, </scie_field_hr><scie_field_en>Electrical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id>23336</team_members_id><team_members_names><![CDATA[ Doktorand: Nina Stipetić ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[high voltage, electric raliway, power quality, EMC, modelling, ICT]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[The Research Project will develop the following implementation of new ICT technologies in High Voltage systems: 1. Application of new information and communication technologies such as lightning location system data for analysis of lightning overvoltages and overvoltage protection optimization:- Develop an original algorithm for lightning location data analyze in order to determinate the lightning flashes from the lightning strokes. - Analyze of collected lightning location date and develop an original algorithm for correlation with protection relay tripping in transmission and distribution lines. 2. Modeling the consumers with a big influence on the power quality in high voltage system- Influence of electric railway system on power quality in 110 kV transmission system.- Model of 25 kV 50 Hz electric railway system for power quality studies (electric locomotive, traction network, traction substation):- Compare the developed model with measurement results obtained on locomotives, electric trains and in electric traction substations.  3. New methods for the assessment of Electromagnetic Compatibility - Methodology for more precise electromagnetic influence calculation of contact line and electric traction system to the metal structure in the vicinity:- Identification and assessing the effect of changing values of model parameters based on the theory of electrical circuits to calculate the induced voltage.4. New models of components in studies of electromagnetic transients in high voltage systems- Development of wideband models for power system components (power and instrument transformers, circuit breakers, surge arresters, shunt reactors).- Summarize and analyze the detailed bibliography on the high frequency electromagnetic behavior of transformers (calculations and measurements). - High frequency transformer modeling.]]></summary_en></project><project>
<id>3867</id><title_hr><![CDATA[Reservoir Computing with Real-time data for future IT]]></title_hr><title_en><![CDATA[]]></title_en><user_id>24947</user_id><user_firstLast_name>Ivor Lončarić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2015-10</proposal_call><code>DOK-2015-10-5449</code><acronim><![CDATA[]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, </scie_field_hr><scie_field_en>Physics, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>22602</team_members_id><team_members_names><![CDATA[ Doktorand: Mihovil Bosnar ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>3869</id><title_hr><![CDATA[Razvoj metodološkog okvira za rješavanje strateških problema u  visokom obrazovanju – primjer implementacije otvorenog učenja i učenja na daljinu]]></title_hr><title_en><![CDATA[]]></title_en><user_id>12531</user_id><user_firstLast_name>Vjeran Strahonja</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2015-10</proposal_call><code>DOK-2015-10-1068</code><acronim><![CDATA[HigherDecision]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Informacijske znanosti, </scie_field_hr><scie_field_en>Information sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet organizacije i informatike]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Organization and Informatics]]></institution_en><team_members_id>25090</team_members_id><team_members_names><![CDATA[ Doktorand: Mišo Džeko ]]></team_members_names><keywords_hr><![CDATA[odlučivanje, e-učenje, otvoreno učenje i učenje na daljinu, visoko obrazovanje, e-spremnost, procjena rizika, kauzalnost, AHP]]></keywords_hr><keywords_en><![CDATA[decision making, e-learning, open and distant learning, higher education, e-readiness, risk assessment, portfolio, causality, AHP]]></keywords_en><summary_hr><![CDATA[Visoko obrazovanje (VO) ima ključnu ulogu u razvoju ljudskih potencijala te u gospodarskom i društvenom razvoju. Stoga, donošenje odluka i praćenje njihove primjene u visokom obrazovanju postaje prvorazredno istraživačko i razvojno pitanje. Primarni istraživački cilj ovog projekta je razvoj cjelovite metodologije donošenja strateške odluke i praćenja njezine provedbe u VO. U svijetu se broj korisnika online edukacije rapidno povećava, a postoje i brojna izvješća koja govore o digitalnoj spremnosti te upotrebi informacijsko-komunikacijske tehnologije (IKT) u VO. Dvije osnovne komponente projekta:1. Razvoj  metodološkog okvira donošenja strateških odluka u VO i praćenje njihove provedbe. 2. Primjena, prilagodba i provjera dane metodologije na primjeru implementacije odluke o uvođenju otvorenog učenja i učenja na daljinu.Istraživanje je interdisciplinarno i povezuje društveno područje (višekriterijsko odlučivanje, IKT, strateško planiranje) i matematiku (matematičko modeliranje, kvantitativne metode u odlučivanju, kauzalne modele i teoriju grafova). Istraživanje rješavanja strateških problema provodimo kroz ciklus strateškog odlučivanja u četiri faze: (1) prepoznavanje i istraživanje problema - identificirat će se i unaprijediti metodologije kao što su procjena spremnosti i difuzija inovacija.(2) razvoj metodologije odlučivanja i donošenja odluke -  istražit će se primjena i unapređenje metodologije višekriterijske analize odluka u VO.(3) provedba i praćenje strateške odluke - identificirati će se ključni faktori koji utječu na uspješnost provedbe strateške odluke i njihove međuzavisnosti i razviti model za mjerenje zrelosti i uspješnosti implementacije strateških odluka u VO.(4) evaluacija učinaka provedbe odluke -  istražit će se mogući pristupi, a posebno evaluacija upotrebom strukturalne teorije kauzalnosti. ]]></summary_hr><summary_en><![CDATA[Higher education’s (HE) key mission is to develop human potential with beneficial effects for the social and economic development. HE as a system, along with HE institutions, must be innovative and strategically managed to be able to fulfill their mission. Therefore, the decision making accompanied by evaluation of its implementation in higher education is an issue of highest priority. Primary goal of this research proposal is to develop a complete methodology for strategic decision making and the monitoring of its implementation in HE. The enrollment rate within online education has skyrocketed worldwide and there are a number of reports on e-readiness and ICT use in HE. Two basic components of the project:1. Development of methodological framework for strategic decision making in HE and monitoring of its implementation. 2. Application, adjustment and evaluation of the methodology on the example of decision implementation on e-learning and distance learning.This is an interdisciplinary project connecting Social Sciences (ICT, multicriteria decision making, strategic planning) and Mathematics (mathematical modeling, quantitative methods in decision making, structural causal models and graph theory).The research is structured as a cycle of strategic decision making with four phases:(1) Intelligence - problem identification and research, advancement of methodologies such as readiness assessment, diffusion of innovation etc.(2) Design of methodology -  design of decision making methodology and decision making, improvement of multicriteria decision analysis in HE.(3) Implementation and monitoring - research and identification of key factors that determine effectiveness of strategic decision, their correlation, design of measuring model for maturity and effectiveness of strategic decision implementation in HE(4) Evaluation - survey possible approaches and evaluation by application of J. Pearl’s structural causal models for identification of effects of strategic decision.]]></summary_en></project><project>
<id>3870</id><title_hr><![CDATA[Antički vodni sustavi grada Salone i Dioklecijanove palače i njihov utjecaj na održivost urbane sredine]]></title_hr><title_en><![CDATA[]]></title_en><user_id>6669</user_id><user_firstLast_name>Jure Margeta</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2015-10</proposal_call><code>DOK-2015-10-8974</code><acronim><![CDATA[RWSCSDP]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Građevinarstvo, </scie_field_hr><scie_field_en>Civil engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Splitu Fakultet građevinarstva, arhitekture i geodezije]]></institution_hr><institution_en><![CDATA[University of Split, Faculty of Civil Engineering, Architecture and Geodesy]]></institution_en><team_members_id>21324</team_members_id><team_members_names><![CDATA[ Doktorand: Olgica Erceg ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[Urban water system, Salona, Diocletian&#39;s palace, Aqueduct, Sewage]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[The aim of the project is to study two Roman Water Systems which are using the same water source - Jadro spring. First one is Water System of Salona, capital of Roman province Dalmatia, from the 1st century, and the second one is of Diocletian&#39;s Palace in Split from 4th century. The study will consist of analysis and reconstruction of two, by its purpose, different Water System, one of typical urban character and another very specific of Emperor Palace. Unlike the Water System of the Palace, which is partly preserved (aqueduct is in function) and therefore more studied, the Water System of Salona is mostly unknown. They will be studied separately using the same methodology.All parts of Water Supply system will be studied: water intake on Jadro spring, route and elements of the aqueduct (channel, bridges and tunnels), water distribution tanks, lead pipe network and water appliances together with water quantity and quality issues. The study of sewage will consider wastewater and storm water drainage, as well as the protection from external surface water and groundwater. Besides those, methods, materials and techniques used by Roman engineers to establish efficient urban Water System indispensable for the life and health of the citizens will be analyzed and compared with modern system. The study will be based on collecting all data regarding explored elements of the Water System and on new archaeological excavations financed by this project. Existing topographic and architectonic surveys will be summarized and supplemented by new ones which will enable reconstruction of the whole system and elements. The project team is multidisciplinary and gathers civil engineers, architects and archaeologist. Apart from new knowledge about the planning, building and maintaining Roman Water Systems this project will give necessary data to protect elements of the system form devastation, to make a proper presentation and even to put some elements is use. ]]></summary_en></project><project>
<id>3871</id><title_hr><![CDATA[Upravljanje povjerenjem i koordinacija interakcija u pametnim mrežama ljudi, strojeva i organizacija]]></title_hr><title_en><![CDATA[]]></title_en><user_id>2602</user_id><user_firstLast_name>Vedran Podobnik</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2015-10</proposal_call><code>DOK-2015-10-1777</code><acronim><![CDATA[SmartPMONetworks]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Računarstvo, </scie_field_hr><scie_field_en>Computer sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id>22815</team_members_id><team_members_names><![CDATA[ Doktorand: Dario  Pevec ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[social networks, machine-to-machine communication, networked organizations, networked society, trust, coordination, context-awareness, big data]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[We live in a networked society where everything is connected. By 2020 there will be 8 billion people and 50 billion machines in the world and almost all of them will be connected through some kind of network. Furthermore, people and machines that share a certain collective goal will be grouped into some kind of organization, which again will be connected with other organizations and/or people/machines. In order to maintain sustainability of the networked society we need a framework and algorithms which will enable us to i) manage trust; and ii) coordinate interactions in such a complex eco-system consisting of thousands, millions or even billions of interconnected entities. Both the framework and algorithms should be scalable and robust (from the perspective of a network size and heterogeneity), support real-time dynamics (from the perspective of network interactions) as well as be applicable and analyzable at different levels of granularity (at a micro, mezzo and macro network levels). A possible solution for the framework is the “Smart Network”, where people/machines/organizations are represented as nodes which are described by profiles and build a network of connections. The “smartness” of “Smart Networks” stems from profiling nodes and realizing connections using automated computational methods, what is enabled by latest enhancements in information systems and state-of-the-art solutions in communication technologies. The “Smart Network” framework enables design of scalable, robust and real-time algorithms for managing trust and coordinating interactions because it can be i) formally operationalized as a graph where edges represent nodes and vertices represent connections; ii) functionally modeled as a multi-agent system where agents embody edges and relationships embody vertices; and iii) analyzed through complexity theory where sustainable solutions emerge as a result of a bottom-up modeling principle.]]></summary_en></project><project>
<id>3872</id><title_hr><![CDATA[Novi koncept primijenjene kognitivne robotike u kliničkoj neuroznanosti]]></title_hr><title_en><![CDATA[]]></title_en><user_id>7302</user_id><user_firstLast_name>Bojan Jerbić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2015-10</proposal_call><code>DOK-2015-10-3073</code><acronim><![CDATA[ACRON]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Strojarstvo, </scie_field_hr><scie_field_en>Mechnical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet strojarstva i brodogradnje]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Mechanical Engineering and Naval Architecture]]></institution_en><team_members_id>22645</team_members_id><team_members_names><![CDATA[ Doktorand: Josip Vidaković ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[robotics, artificial intelligence, cognitive models, medicine, neuroscience]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[The research in this project leads to novel forms and uses of cognitive robotics applied in clinical neuroscience. Robot’s performances during the surgical procedures are investigated within the previously conducted technological project, RONNA - Robotic Neurosurgical Navigation. Results of RONNA suggest that the benefits of using robots in the operating room are enormous, e.g. increased accuracy and repeatability of the surgical procedures, flexible and tremor free operations, etc. During the RONNA realisation, it is recognized that certain new cognitive robot skills yet need to be developed.The long-term vision of the proposed ACRON project as a multi-disciplinary research arises from the recognition that a paradigm shift in human-robot-environment interaction is needed. Currently, technology robustness is achieved by restricting the interaction space, so that the region and the nature of the interaction can be controlled by the system. In ACRON, the cognitive fulcrum will therefore move from sensed data to the robot contextual anticipation.ACRON will advance the research providing a uniform scientific framework for the study, development and implementation of cognitive concepts, providing the robot to function in ICT enabled ubiquitous environment that can be shared by different kinds of agents. ACRON will therefore bring the new context-aware medical robot capable to anticipate the most appropriate actions respecting the phase of the medical procedure and spatial positions of the staff and objects. We will investigate the relationship between people, robots and the shared environment where they interact and work together. By moving throughout the discretized working space and while achieving the current assignment, the medical robot will become able to avoid all-possible spatial collisions and make the appropriate context-based decisions.]]></summary_en></project><project>
<id>3873</id><title_hr><![CDATA[Procjena ponašanja konstrukcija u graničnim uvjetima rada]]></title_hr><title_en><![CDATA[]]></title_en><user_id>3329</user_id><user_firstLast_name>Domagoj Lanc</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2015-10</proposal_call><code>DOK-2015-10-5028</code><acronim><![CDATA[STRUBECON]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Temeljne tehničke znanosti, </scie_field_hr><scie_field_en>Basic engineering sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Tehnički fakultet]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Engineering]]></institution_en><team_members_id>23703</team_members_id><team_members_names><![CDATA[ Doktorand: Sandra Kvaternik ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[structures, material properties, experimental investigations, numerical investigations, limit state, assessment of structural behaviour]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Structures are designed according to their purpose taking into account all relevant service life requirements, which are usually related to a factor of safety, material properties, service life conditions and of course service life prediction. Structure may be sometimes exposed to unexpected conditions, let say adverse or hazard conditions. These conditions may cause failures making structure incapable to perform the function for which it has been designed. The task is to make an assessment of the structure behaviour at mentioned conditions and decide if the structure is capable for further operation. This means the assessment should provide an answer if the structure has sustained irreparable damage. Therefore, the main objective is to provide an assessment of structure behaviour, by comparing of the parameters like stress, strain, crack occurring, etc., caused by certain load level and temperature at this unexpected limit state with those allowed by material properties. To assess structural behaviour in operation at limit state, the following research sub-objectives should be accomplished: testing of material properties for the different environmental conditions; definition of impact energy as well as the determination of the crack driving force and life assessment of structural elements; evaluation of the semi-rigid structural joints/connections behaviour; development of a numerical algorithm for optimization of semi-rigid framed structures; creep buckling simulations of composite beam-type structures; proper constitutive modelling at limit operating conditions (i.e. plasticity, damage, thermomechanical coupling); application of new materials to be used at limit state – nanocomposites. Targeted structures are single and multi storey steel buildings, rigs, high-power electrical transmission towers, ship structures, etc.]]></summary_en></project><project>
<id>3874</id><title_hr><![CDATA[Višeskalno numeričko modeliranje deformiranja materijala od makro do nanorazine]]></title_hr><title_en><![CDATA[]]></title_en><user_id>3311</user_id><user_firstLast_name>Zdenko Tonković</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2015-10</proposal_call><code>DOK-2015-10-3372</code><acronim><![CDATA[MNumMacroNano]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Strojarstvo, </scie_field_hr><scie_field_en>Mechnical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet strojarstva i brodogradnje]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Mechanical Engineering and Naval Architecture]]></institution_en><team_members_id>21241</team_members_id><team_members_names><![CDATA[ Doktorand: Karlo Seleš ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[Engineering materials, bilogical tissues, multiscale modeling, finite element  method, meshless method, damage modeling, molecular dynamics]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Many engineering materials as well as biological tissues have a heterogeneous structure particularly when they are observed at microlevel. In order to assess structural integrity as well as to predict structural lifetime, an analysis at microlevel is required. In recent years, a special attention has been directed to the investigation of relations between macroscopic properties of materials and their microstructure as well as to perform a link to atomistic scale. Since classical continuum mechanics cannot consider structural effects in the material at the micro- and nanolevel, multiscale techniques are developed that model material deformation responses at multiple levels using appropriate numerical procedures. Deformation responses of arteries will be considered by using multiscale computational strategy too. A special attention will be directed toward the mathematical modeling of arterial growth and remodeling, which could help physicians to track certain cardiovascular diseases and predict their development. For modeling of engineering materials, a new micro-macro numerical procedure based on the second-order computational homogenization approach employing nonlocal continuum theory will be proposed. Both finite element and meshless spatial discretization will be applied. The damage evaluation at the microlevel which may lead to macroscopic fracture will be modeled. Here the damage evaluation law based on the computational averaging procedure will be used and the modeling at atomistic scale will be performed in the very narrow domain of localization. In the atomistic modeling using molecular dynamics, a special attention will be directed to the coupling of atomistic domain with the discretized continuum domain. An approach inspired by the quasicontinuum and bridging domain will be proposed. All results of the research will be tested by the modeling deformation responses of realistic materials.]]></summary_en></project><project>
<id>3875</id><title_hr><![CDATA[SPECTRESS - Social Performance, Cultural Trauma and the Reestablishing of Solid Sovereignties]]></title_hr><title_en><![CDATA[]]></title_en><user_id>12609</user_id><user_firstLast_name>Davor Dukić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2015-10</proposal_call><code>DOK-2015-10-1353</code><acronim><![CDATA[]]></acronim><duration>01.01.2017 - 19.08.2022</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Filologija, </scie_field_hr><scie_field_en>Philology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Filozofski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Humanities and Social Sciences]]></institution_en><team_members_id>858310</team_members_id><team_members_names><![CDATA[ Doktorand: Marija Fiolić ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>3876</id><title_hr><![CDATA[PRIMJENA CIJEVNIH PROPUSTA ZA POBOLJŠANJE KVALITETE MORA U LUKAMA/MARINAMA]]></title_hr><title_en><![CDATA[]]></title_en><user_id>4885</user_id><user_firstLast_name>Dalibor Carević</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2015-10</proposal_call><code>DOK-2015-10-9770</code><acronim><![CDATA[EKO MARINA]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Građevinarstvo, </scie_field_hr><scie_field_en>Civil engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Građevinski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Civil Engineering]]></institution_en><team_members_id>22817</team_members_id><team_members_names><![CDATA[ Doktorand: Damjan Bujak ]]></team_members_names><keywords_hr><![CDATA[cijevni propusti, izmjena mora, vrijeme zadržavanja, cirkulacija u luci, eko marina]]></keywords_hr><keywords_en><![CDATA[flushing culverts, residence time, flushing time, sea exchange, eko marina]]></keywords_en><summary_hr><![CDATA[Ovaj projekt donosi zaključke o mjerama koje trebaju biti primijenjene u svrhu osiguranja dovoljne izmjene vode u budućim lukama upotrebom cijevnih propusta. Ugradnja cijevnih propusta u konstrukciju lukobrana je najjeftinija metoda, između ostalih. Svrha cijevnih propusta je da omoguće izmjenu vode između otvorenog mora i mora zatvorenog u luci. Generalno postoji manjak znanja koji bi opisivao funkcioniranje cijevnih propusta kao instrumenta za izmjenjivanje vode. Slijedeća pitanja trebaju biti odgovorena kroz faze ovoga projekta: 1. FAZA I: Koja se veličina protoka ostvaruje u propustima pod djelovanjem vjetrovnih valova, i kolika je vrijednost transmitirane valne energije? Metodologija: Fizikalni model u laboratoriju (u valnom kanalu) sa modelom cijevnih propusta. 2. FAZA II: Funkcioniranje cijevnih propusta u realnim uvjetima (u stvarnoj luci), što znači, složeni uvjeti istovremenog djelovanja valova s vanjske strane luke zajedno sa plimnim oscilacijama i vjetrovnom cirkulacijom mora (koji je protok u propustima u takvim uvjetima?). Metodologija: Sveobuhvatna terenska mjerenja u marini Ičići (Opatija) u svrhu kalibracije 3D numeričkog modela. 3. FAZA III: Koliko pozija propusta u tijelu lukobrana doprinosi protoku u propustima? Metodologija: 3D numeričko modeliranje.Općenita svrha istraživanja je razotkriti funkcioniranje cijevnih propusta korištenjem laboratorijskih modela, terenskih istraživanja i numeričkog modeliranja. Rezultat istraživanja će biti inženjerske preporuke i jednostavni matematički modeli (jednadžbe, grafovi) koji će pomoći inženjerima u optimalnom projektiranju cijevnih propusta.]]></summary_hr><summary_en><![CDATA[This project provide conclusions on measures that need to be implemented in order to secure enough exchange of water mass in future harbors using flushing culverts (pipes). Installation of flushing culverts inside the breakwater structure is the most cost-effective method, among others. The purpose of culverts is to enable the exchange of the open sea water and the water contained within a protected maritime zone. There is a general lack in research that would provide an explanation on how pipe culverts actually work as a sea water exchange instrument. The next answers should be reached through phases of this project. 1. PHASE I: What is the amount of water discharge in culverts under the agency of surface wind waves, and what is the amount of wave energy transmission?. Methodology: Physical model in laboratory (wave channel) with flushing culverts model. 2. PHASE II: Functioning of flushing culverts in a realistic conditions (in real harbor), which means, the complex conditions of simultaneous actions of waves coming from outside a harbor along with tidal oscillations and wind driven circulation of sea (what is the water discharge in culverts in such conditions?). Methodology: Extensive field measurements in Ičići marina (Opatija) with purpose on calibration of 3D numerical model . 3. PHASE III: How much does positions of culverts in breakwater’s body contributes to the culverts discharge? Methodology: 3D numerical modelling. The overall purpose of the research is to discover flushing culverts functioning using laboratory models, field measurements and numerical modelling The result of the research would be engineering guides and simple mathematical models (equations, graphs) that would help engineers in optimal design of the flushing culverts. ]]></summary_en></project><project>
<id>3877</id><title_hr><![CDATA[Market uptake of small modular renewable district heating and cooling grids for communities (CoolHeating)]]></title_hr><title_en><![CDATA[]]></title_en><user_id>13012</user_id><user_firstLast_name>Neven Duić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2015-10</proposal_call><code>DOK-2015-10-1739</code><acronim><![CDATA[]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Strojarstvo, </scie_field_hr><scie_field_en>Mechnical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet strojarstva i brodogradnje]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Mechanical Engineering and Naval Architecture]]></institution_en><team_members_id>22648</team_members_id><team_members_names><![CDATA[ Doktorand: Matija Pavičević ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>3878</id><title_hr><![CDATA[Wrist and arm sensing technologies for cardiac arrhythmias detection]]></title_hr><title_en><![CDATA[]]></title_en><user_id>18917</user_id><user_firstLast_name>Ratko Magjarević</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2015-10</proposal_call><code>DOK-2015-10-1132</code><acronim><![CDATA[]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Elektrotehnika, </scie_field_hr><scie_field_en>Electrical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id>25143</team_members_id><team_members_names><![CDATA[ Doktorand: Dominik Džaja ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>3883</id><title_hr><![CDATA[Ispitivanje reaktivnosti trombocita u različitim srčanožilnim bolestima]]></title_hr><title_en><![CDATA[]]></title_en><user_id>7462</user_id><user_firstLast_name>Davor  Miličić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2015-10</proposal_call><code>DOK-2015-10-3918</code><acronim><![CDATA[SPARELIFE-CVD]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Kliničke medicinske znanosti, </scie_field_hr><scie_field_en>Clinical sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb School of Medicine]]></institution_en><team_members_id>21231</team_members_id><team_members_names><![CDATA[ Doktorand: Saša Pavasović ]]></team_members_names><keywords_hr><![CDATA[kardiovaskularne bolesti, reaktivnost trombocita, agregometrija, personalizirana kardiologija, klinički ishodi]]></keywords_hr><keywords_en><![CDATA[cardiovascular diseases, platelet reactivity, aggregometry, personalized cardiology, clinical outcomes]]></keywords_en><summary_hr><![CDATA[Predloženi projekt je nastavak dosadašnjeg rada u kojem se nastoji ispitati značaj reaktivnosti trombocita u različitim srčanožilnim oboljenjima te mogućnost da se individualiziranom primjenom antitrombocitnih lijekova prema vrijednostima reaktivnosti trombocita poboljšaju klinički ishodi. Istraživanje je podijeljeno u pet cjelina koje će se paralelno provoditi. Prva cjelina obuhvaća nastavak istraživanja utjecaja povišene ostatne reaktivnosti trombocita i individualiziranog pristupa primjene antitrombocitne terapije u bolesnika s akutnim koronarnim sindromom. Druga cjelina će istraživati promjene reaktivnosti trombocita kod bolesnika nakon izvanbolničkog aresta koji se podvrgavaju protokolu terapijske hipotermije. Nedovoljno je istraženo kako kontrolirano snižena tjelesna temperatura utječe na agregacijsku kaskadu in vivo, osobito u bolesnika koji se liječe antitrombocitnim lijekovima. Treća cjelina će obuhvatiti bolesnike koji se liječe mehaničkom cirkulacijskom potporom zbog terminalne faze srčanog popuštanja. U toj skupini evaluirat ćemo reaktivnost trombocita povezanu s korištenjem izvantjelesnog krvotoka odnosno mehaničkih srčanih crpki i povezanost s trombozama uređaja i s krvarenjima. U četvrtoj cjelini istraživat ćemo ulogu funkcije trombocita u sekundarnoj plućnoj hipertenziji uzrokovanoj bolešću miokarda lijeve klijetke (WHO tip II). Povezanost reaktivnosti trombocita i težine bolesti je već pokazana u primarnoj plućnoj hipertenziji, ali ne i u mnogo češćoj, plućnoj hipertenziji tipa II. Rezultati bi mogli pridonijeti poznavanju patofiziologije sekundarne plućne hipertenzije tipa II s mogućim terapijskim implikacijama, jer se namjerava ispitati, moduliraju li promjene reaktivnosti trombocita vazoaktivni odgovor na prostaglandin E1. Posljednja, peta cjelina će biti posvećena ispitivanju prognostičkog značenja reaktivnosti trombocita na razvoj koronarne vaskulopatije u bolesnika nakon presadbe srca što do sada nije istraživano.]]></summary_hr><summary_en><![CDATA[The proposed project represents a continuation of our previous work which will examine the significance of platelet reactivity (PR) in a variety of cardiovascular diseases and the potential of individualized approach in antiplatelet therapy regimen based on the values of PR to improve clinical outcomes. The research will be divided into five arms that will be conducted simultaneously. The first arm will be the continuation of our research on the impact of high on-treatment platelet reactivity and individualized approach to the application of antiplatelet therapy in patients with acute coronary syndrome. The second arm will study the changes of PR in patients with out-of-hospital cardiac arrest who undergo therapeutic hypothermia protocol. It is insufficiently explored how a controlled low body temperature affects the aggregation cascade in vivo, particularly in patients treated with antiplatelet drugs. The third arm will include patients with implanted mechanical circulatory support (MCS) due to end-stage heart failure. In this group we will evaluate the association of PR levels in patients with MCS and device thromboses as well as bleeding events. In the fourth study arm we will investigate the role of platelet function in secondary pulmonary hypertension caused by left ventricular myocardial disease (WHO type II). Correlation between PR and the severity of the disease has been shown in primary pulmonary hypertension, but not in much more frequent, type II pulmonary hypertension. The results might contribute to the knowledge of the pathophysiology of pulmonary hypertension, with potential therapeutic implications as we intend to examine whether the changes in PR modulate the response to vasoactive prostaglandin E1. The last, fifth arm will be devoted to heart transplant patients where we will examine the prognostic significance of PR in the development of coronary vasculopathy after heart transplantation which has not been investigated so far.]]></summary_en></project><project>
<id>3885</id><title_hr><![CDATA[Profesionalne aspiracije prema STEM zanimanjima tijekom osnovne škole: longitudinalno istraživanje odnosa postignuća, vjerovanja o vlastitim kompetencijama i interesa za zanimanja]]></title_hr><title_en><![CDATA[]]></title_en><user_id>6293</user_id><user_firstLast_name>Toni Babarović</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2015-10</proposal_call><code>DOK-2015-10-3999</code><acronim><![CDATA[JOBSTEM]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Psihologija, </scie_field_hr><scie_field_en>Psychology, </scie_field_en><institution_hr><![CDATA[Institut društvenih znanosti Ivo Pilar]]></institution_hr><institution_en><![CDATA[Institute of Social Sciences Ivo Pilar in Zagreb]]></institution_en><team_members_id>21321</team_members_id><team_members_names><![CDATA[ Doktorand: Mara Šimunović ]]></team_members_names><keywords_hr><![CDATA[STEM područje, odabir zanimanja, školska postignuća, pojam o sebi, longitudinalna istraživanja, učinci intervencija]]></keywords_hr><keywords_en><![CDATA[STEM, vocational interest, school achievement, self-concept, self-competence beliefs, longitudinal studies, effectiveness of interventions]]></keywords_en><summary_hr><![CDATA[U globaliziranom, brzo mijenjajućem svijetu, pitanja obrazovnog postignuća i aspiracija mladih prema pojedinim zanimanjima od izuzetnog su značaja. To se posebno odnosi na zanimanja u području znanosti, tehnologije, inženjerstva i matematike (STEM), tehnološki sofisticiranim i inovativnim zanimanjima važnim za društveni razvoj. Od devedesetih na ovamo naklonost mladih upravo za takva zanimanja stalno opada. Istraživači, nositelji politika i institucije poput EU suočeni su s jasnim podacima o evidentnom nedostatku studenata u STEM programima te nedostatku pojedinih STEM stručnjaka.Predloženi projekt temelji se na suvremenim teorijama akademskog postignuća, vjerovanja o vlastitoj kompetenciji u akademskoj domeni i interesa za zanimanja te je strukturiran oko tri glavna istraživačka cilja: (i) ispitati kako se kod učenika opći i specifični interesi za STEM zanimanja stvaraju te mijenjaju li se tijekom vremena; (ii) ispitati odnos školskog postignuća učenika i vjerovanja o vlastitoj kompetenciji s općim i specifičnim interesima za STEM zanimanja, te testirati da li se obrazac tih odnosa mijenja tijekom osnovnoškolskog obrazovanja; (iii) ispitati kako obitelji i spol/rod oblikuju opće i specifične interese učenika vezane uz STEM karijere.Projekt se temelji na longitudinalno-sekvencijalnom istraživačkom nacrtu, složenom metodološkom okviru koji dozvoljava sagledavanje ovakvih istraživačkih pitanja. Ukupno će biti praćeno 1920 učenika osnovnih škola i njihovih roditelja/staratelja, podijeljenih u tri dobne kohorte, koje će se longitudinalno ispitivati kroz tri vala mjerenja. Dodatni je cilj projekta implementirati STEM intervencijski program u osnovne škole te sagledati njegove učinke u kontekstu STEM zanimanja, gdje će se koristiti esperimentalni nacrt s testiranjem prije i nakon tretmana u dvije skupine. Očekujemo da će sve poduzete aktivosti povećati sadašnja znanja, biti poticajne drugim istraživačima, a stečeno znanje korisno učenicima, učiteljima i donositeljima odluka.]]></summary_hr><summary_en><![CDATA[In the globalized and rapidly changing world, the issues of young people’s educational achievement and career aspirations are extremely important. These issues are especially relevant in vocations in the fields of Science, Technology, Engineering and Mathematics (STEM), which are technologically sophisticated and important for the development of the society. Since 1990s the interest of youth for these vocations is declining. Researchers, national governments and authorities like EU operate with exact figures which clearly demonstrate a shortage of STEM graduates and a decline in number of STEM experts.  The proposed project is grounded in contemporary theories of academic achievement, self-competence beliefs and vocational interests and it is structured around three main research goals: (i) to examine how students’ general and specific STEM career aspirations are formed and how they change over time; (ii) to examine how students’ academic achievement and self-competence beliefs are related to their general and specific STEM career aspirations and how the pattern of relations among them changes during the course of primary schooling; (iii) to examine how students’ general and specific STEM career aspirations are shaped by their families and gender. The project is based on a longitudinal research design, as a suitable methodological framework for responding to these complex research questions. A total of 1920 primary school students and their parents/guardians will participate in the study. Students will be grouped in three age cohorts, which will be followed longitudinally through three measurement waves. The additional goal of the project is to implement a STEM intervention program in primary schools and evaluate its’ effects by using two-group pre- and post-test randomized experimental design. The project is intended to create new knowledge useful for researchers, students, teachers as well to create knowledge-based implications for relevant stakeholders.]]></summary_en></project><project>
<id>3889</id><title_hr><![CDATA[Enzimi purinskog reciklirajućeg ciklusa iz Helicobacter pylori i Escherichie coli ]]></title_hr><title_en><![CDATA[]]></title_en><user_id>690</user_id><user_firstLast_name>Ivana Leščić Ašler</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2015-10</proposal_call><code>DOK-2015-10-2664</code><acronim><![CDATA[PSPE]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, </scie_field_hr><scie_field_en>Chemistry, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>23182</team_members_id><team_members_names><![CDATA[ Doktorand: Ante Bubić ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[Purine metabolism, enzyme inhibiton, drug design, H. pylori, E. coli, crystal structure, analytical biochemistry, H/D exchange, susceptibility testing]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[The main goal of the proposed project is to identify new drug targets and accordingly design, prepare and characterise new drugs for Helicobacter pylori eradication. Helicobacter pylori is a bacterium that colonizes one half of the world population and it is regarded as one of the most invasive human pathogens responsible for development of many diseases. There are two possible pathways that organisms can use to synthesize purines as indispensable building blocks for DNA and RNA synthesis. However, bacterium H. pylori  uses the salvage pathway, only. Therefore, we plan to disable H. pylori growth and replication by inhibiting the key enzymes, purine nucleoside phosphorylase and adenylosuccinate synthetase, on this pathway.The proposed project includes the interdisciplinary team with expertise in the research areas of molecular biology and genetics, biochemistry and biophysics, macromolecular crystallography, biological mass spectrometry, molecular modelling, organic synthesis, analytical ultracentrifugation methods, susceptibility testing, and managing ‘big data’ through data integration (extracted from various databases). All equipment necessary to accomplish the proposed research is available in the host institution (Rudjer Bošković Institute) except for analytical ultracentrifuge available by foreign co-worker A. Bzowska (Warsaw, Poland).]]></summary_en></project><project>
<id>3893</id><title_hr><![CDATA[Patofiziološke posljedice promjene sastava lipidnih splavi (Raft Tuning)]]></title_hr><title_en><![CDATA[]]></title_en><user_id>4409</user_id><user_firstLast_name>Marija Heffer</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2015-10</proposal_call><code>DOK-2015-10-7725</code><acronim><![CDATA[]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište Josipa Jurja Strossmayera u Osijeku, Medicinski fakultet Osijek]]></institution_hr><institution_en><![CDATA[Josip Juraj Strossmayer University of Osijek, Faculty of Medicine]]></institution_en><team_members_id>22754</team_members_id><team_members_names><![CDATA[ Doktorand: Milorad Zjalić ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>3894</id><title_hr><![CDATA[Iznad Nyquistove granice]]></title_hr><title_en><![CDATA[]]></title_en><user_id>6982</user_id><user_firstLast_name>Damir Seršić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2015-10</proposal_call><code>DOK-2015-10-1316</code><acronim><![CDATA[BeyondLimit]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Elektrotehnika, </scie_field_hr><scie_field_en>Electrical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id>22636</team_members_id><team_members_names><![CDATA[ Doktorand: Ivan Ralašić ]]></team_members_names><keywords_hr><![CDATA[pod-Nyquistovsko uzorkovanje, sažimajuće očitavanje, kauzalni splajnovi, rijetke reprezentacije, adaptivni valići, napredni dizajn sustava]]></keywords_hr><keywords_en><![CDATA[sub-Nyquist sampling, compressive sensing, causal splines, sparse representations, adaptive wavelets, advanced system design]]></keywords_en><summary_hr><![CDATA[Moderne informacijske i komunikacijske tehnologije suočene su s nizom izazova. Među njima izdvojili smo dva važna: ogromnu količinu podataka koja dolazi iz realnog svijeta putem senzora, kao i snagu računala potrebnu za njihovu obradu. U ovom projektnom prijedlogu smo se usmjerili na oba navedena izazova, kao i na napredne primjene ponuđenih rješenja.Desetljećima, Nyquistova granica postavlja doseg rada digitalnih elektroničkih sustava koji djeluju u analognom svijetu. Korištenjem našeg prethodnog istraživanja u području kauzalnih splajnova, adaptivnih valića, rijetkih reprezentacija te naprednog dizajna sustava, razvit ćemo originalni sustav koji radi iznad Nyquistove granice. Pod-Nyquistovsko uzorkovanje u uniji analognih potprostora te sažimajuće očitavanje su područja istraživanja korištena za postizanje ovog cilja. Obje tehnike rezultiraju aplikacijama koje idu preko poznatih granica: rezultiraju u novim tehnikama prikupljanja i obrade slika, naprednim radarskim i sonarskim uređajima, širokopojasnom programski definiranom radiju, kao i naprednim sustavima za obradu govornih i audio signala. Oslanjaju se na rijetke reprezentacije signala, sofisticiranu rekonstrukciju i algoritme za obradu signala, kao i na inteligentne implementacije koje kombiniraju analogne i digitalne podsustave.Istraživači okupljeni u ovom projektnom timu imaju iskustvo u modeliranju rijetkim signalima, dizajnu naprednih analognih i digitalnih sustava, a razvili su i različite aplikacije u obradi slika, audio i govornih signala. Razvit ćemo originalan sustav iznad Nyquistove granice zasnovan na našim kauzalnim splajnovima. Koristit ćemo naše adaptivne sustave i brze L1 minimizacijske algoritme radi postizanja rijetkih reprezentacija potrebnih u sažimajućem očitavanju. Rezultati će se koristiti u dizajnu novog pod-Nyquistovog sustava, čija će se realizacija oslanjati na naš napredni dizajn. Razvit ćemo aplikacije u obradi 3D signala, slika te obradi audio i govornih signala.]]></summary_hr><summary_en><![CDATA[Modern information and communication technologies face various challenges. We identified two of them as important: huge amount of data delivered from the real world via sensing devices, and computing power required for its processing. Both challenges are targeted in our project proposal, as well as some advanced applications of the proposed solutions.For decades, Nyquist limit sets the achievable work range of digital electronic systems operating in an analogue world. Using our previous research and expertise in causal splines, adaptive wavelets, sparse representations, and advanced system design, we will develop an original system that works beyond the Nyquist limit. Sub-Nyquist sampling in a union of analogue subspaces and compressive sensing are research topics used to achieve this goal. Both approaches result in applications that go beyond the known limits: they result in novel imaging techniques, advanced radar and sonar devices, wide-band software defined radios, as well as in advanced speech and audio processing systems. They rely on sparse representation of signals, sophisticated reconstruction and signal processing algorithms, as well as on intelligent hardware implementations that mix analogue and digital subsystems. The researchers gathered in this project team have research experience in causal splines, adaptive wavelets and sparse signal modeling, as well as in design of advanced analogue and digital systems. They have developed various applications in image, audio and speech signal processing. We will develop an original beyond Nyquist system based on our causal splines. We will use our adaptive systems and fast L1 minimization algorithms to achieve sparse representations needed in compressive sensing. The results will be used in design of novel sub-Nyquist systems, whose realization will rely on our advanced system design. We will develop its applications in 3D, image, audio and speech signal processing.]]></summary_en></project><project>
<id>3895</id><title_hr><![CDATA[Mjeriteljska infrastruktura za pametne mreže]]></title_hr><title_en><![CDATA[]]></title_en><user_id>5372</user_id><user_firstLast_name>Roman Malarić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2015-10</proposal_call><code>DOK-2015-10-9707</code><acronim><![CDATA[SMAGRIMET]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Elektrotehnika, </scie_field_hr><scie_field_en>Electrical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id>21317</team_members_id><team_members_names><![CDATA[ Doktorand: Jure Konjevod ]]></team_members_names><keywords_hr><![CDATA[Pametne mreže, mjeriteljstvo, precizne mjerne metode, mjerenje snage, mjerenje energije]]></keywords_hr><keywords_en><![CDATA[Smart grid, metrology, precise measurement methods, measurement of power, measurement of energy]]></keywords_en><summary_hr><![CDATA[Cilj ovog projekta je izgradnja nacionalne mjeriteljske infrastrukture za podršku Smart Grid tehnologiji, koja u potpunosti nedostaje u trenutnoj hrvatskoj mjeriteljskoj infrastrukturi. Nedostaje čak i nacionalni etalon za snagu i energiju. SMAGRIMET će biti glavni centar za istraživanje i razvoj potrebne mjeriteljske infrastrukture u Republici Hrvatskoj za smart grid i srodna znanstvena područja koji će učinkovito premostiti jaz između hrvatske i europske mjeriteljske infrastrukture. Većina europskih mjeriteljskih instituta sudjelovala je u projektu razvoja Smart Grid mjeriteljske infrastrukture u kojem Hrvatska nije sudjelovala zbog nedostatka infrastrukture za mjerenje snage i energije i povezanih istraživanja vezana za pametne mreže. Istraživanje u ovom projektu će biti usmjereno na razvoj vrlo preciznih naponskih i strujnih mjernih pretvornika, pomoću analogno digitalnih pretvornika i koristeći nove algoritme za preciznu analizu mjernih podataka. Ovaj istraživački projekt će adresirati niz mjeriteljskih izazova koji će pružiti neophodnu podršku kako bi se osigurala sigurnost opskrbe električnom energijom i stabilnost mreže. Izazovi su mnogi: Mjerni okvir za nadzor i stabilnost pametne mreže, sljedivost mjerenja na udaljenim lokacijama energetske infrastrukture koji osiguravaju pravednu trgovinu energijom, daljinsko mjerenje u energetskim postrojenjima i kućanstvima, kvalitetu i učinkovitost energije te modeliranje, simulacija i analiza stanja pametne mreže. Također, uvođenje novog standarda IEC 61850 će promijeniti način na koji će trafostanica funkcionirati u budućnosti, a novi izazovi i rješenja tek trebaju biti istraženi i razvijeni. ]]></summary_hr><summary_en><![CDATA[The aim of this project is to build national metrology infrastructure to support smart grid technology and research, as it is completely lacking in the current Croatian metrology infrastructure. Even, the power and energy national standard is missing.The SMAGRIMET will be main centre for research and development of necessary metrological infrastructure in Croatia for smart grid and related scientific fields that will effectively bridge the gap between the Croatian metrological infrastructure and European counterparts. Most of the European metrological institutes have contributed to the European Smart grid metrology project in which Croatia has not taken part because of the lack of infrastructure for measuring power and energy and related issues related to smart grids.The research will be focused in developing highly accurate voltage and current transducers, using precision sampling devices and using new algorithms to accurately analyse measurement data.This research project addresses a series of metrological challenges that will provide essential support to ensure security of electricity supply and grid stability, grid quality, and fair trade between commercial parties employing the grid. The challenges are many: Measurement framework for monitoring stability of smart grids, traceable on-site energy measurement systems for ensuring fair energy trade, remote on-site measurement of power quality and efficiency and modelling, simulation and network analysis of the system state of smart grids-. Also the introduction of the new standard IEC 61850 will change the way the substation will function in the future. The standard makes new challenges and solutions have yet to be researched and developed.]]></summary_en></project><project>
<id>3898</id><title_hr><![CDATA[Histološka, MRI i analiza genske ekspresije reorganizacijskih procesa u medijalnom (limbičkom) zidu ljudskog mozga tijekom razvitka]]></title_hr><title_en><![CDATA[]]></title_en><user_id>6256</user_id><user_firstLast_name>Nataša Jovanov Milošević</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2015-10</proposal_call><code>DOK-2015-10-3939</code><acronim><![CDATA[MEDCEREB]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb School of Medicine]]></institution_en><team_members_id>22600</team_members_id><team_members_names><![CDATA[ Doktorand: MIHAELA BOBIĆ ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[subplate, marginal zone, human brain development, immunohistochemistry, gene expression, in situ hybridization, MRI analysis, hippocampus, cingulum]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[The salient feature of the human fetal cortex is the presence of the subplate zone (SP), a prominent, synapse rich compartment composed of „waiting“ afferents, loosely arranged axons, synapses, growth cones, migratory neurons, glial cells and extraordinary amount of extracellular matric molecules (ECM). The medial (limbic) cortical regions (areas involved in emotion and memory functions) develop a different laminar structure in comparison with lateral cortical regions. Unlike the lateral cortex, where the SP is a major site of neurogenetic events, in the medial archicortex marginal zone (MZ) seems to be a key zone for early molecular neuronal interactions, synaptogenesis and patterning of growing pathways. The goal of this project is to correlate developmental reorganization of major cellular (cell bodies, growing axons) components of the SP and the MZ in developing medial wall of the human cerebrum (cingulum, hippocampus, amygdala) by combining immunochistochemistry, in situ hybridization, transcriptome analysis with in vivo/in vitro MRI. Histological analysis wiil be performed on postmortem human brains, ranging from 10 postconceptional weeks (POW) to 6.5 years, to analyze the expression patterns of different developmentally regulated proteins in relation to synaptic, laminar, neuronal, glial and ECM development. These results will be correlated with in vivo/in vitro MRI findings obtained in age-matched fetuses, infants and children. In addition, we will also analyze publicly available gene expression database (Kang et al., 2011) to investigate the relationship between structural changes and spatio-temporal expression of specific candidate genes. For the selected candidate genes we will perform in situ hybridization and immunocytochemistry in order to elucidate in which cells are these genes expressed. The obtained data will be used for setting the baseline for studying developmental abnormalities characteristic for diverse neurological disorders]]></summary_en></project><project>
<id>3899</id><title_hr><![CDATA[Logika, pojmovi i komunikacija]]></title_hr><title_en><![CDATA[]]></title_en><user_id>91</user_id><user_firstLast_name>Srećko Kovač</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2015-10</proposal_call><code>DOK-2015-10-9955</code><acronim><![CDATA[LogiCCom]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Filozofija, </scie_field_hr><scie_field_en>Philosophy, </scie_field_en><institution_hr><![CDATA[Institut za filozofiju]]></institution_hr><institution_en><![CDATA[Institute for Philosophy in Zagreb]]></institution_en><team_members_id>13057</team_members_id><team_members_names><![CDATA[ Doktorand: Ivan Restović ]]></team_members_names><keywords_hr><![CDATA[logika, pojam, ontologija, znanje, pragmatika, Kant, Bolzano, Frege]]></keywords_hr><keywords_en><![CDATA[logic, concept, ontology, knowledge, pragmatics, Kant, Bolzano, Frege]]></keywords_en><summary_hr><![CDATA[Cilj je projekta reafirmacija temeljne uloge pojmova kao intenzija u logici kao i formalne pragmatike porabe pojmova u zaključivanju. Taj se cilj želi postići  istraživanjem koje na unutrašnji način povezuje intenzionalni i pragmatički pristup logici.Istraživanje ima četiri glavna aspekta unutar kojih se želi pokazati osnovna uloga pojmova: logika pojmova, pojmovni temelji ontologije, pojmovni temelji znanja i  društvena pragmatika pojmova.1) Istražit će se intenzionalna narav pojmova kao osnovanih na logičkim radnjama apstraktnih činitelja koji zaključuju (apstraktna pragmatika). Ispitat će se moguće intenzionalno podrijetlo klasičnih logičkih zakona. Pojmovima će se pristupiti  sa stajlišta logike prvoga reda i teorije tipova. Želi se ispitati hipoteza prema kojoj se intenzionalna logika i logički pojmovi mogu opisati pomoću pojmova objektivnosti i (prema Gödelovoj hipotezi)  uzročnosti.2) Ispitat će se intenzionalna bit temeljnih ontologijskih pojmova na primjeru  formalizacije Bolzanove ontologijske teorije, u usporedbi s Leibnizovom ontologijom. Istraživanje će se usredotočiti na pojmove supstancije, adherencije/inherencije i cjelina-dio.3) Želi se pokazati doprinos pojmova objektivnoj vrijednosti znanja, osobito  u  matematici, i u oslonu na Fregeovu teoriju pojmova. Posebno će se istraživati međuodnos pojmovnoga i predmetnoga sadržaja u analitičnim iskazima i iskazima prvoga reda.4) Analizirat će se uzročna uloga logičkih pojmova i jezika u kontekstu njihove porabe u govornim činovima i argumentacijskome dijalogu. Pokazat će se da je pragmatika bitna sastavnica logike, te da se, kao i sintaksa i semantika, može rigorozno formalizirati. Ktomu, istraživanje želi pokazati da je uporaba logike i jezika primarni izvor opisa pojmova.]]></summary_hr><summary_en><![CDATA[The project aims at re-establishing the fundamental role of concepts as intensions in logic as well as of formal pragmatics of the use of concepts in reasoning. This aim is to be achieved by means of the research that will intrinsically interconnect the intensional and pragmatic approach to logic. The research has four main aspects within which the basic role of concepts is aimed to be shown: logic of concepts, conceptual foundations of ontology, conceptual foundations of knowledge, and social pragmatics of concepts.1) The intensional nature of concepts will be investigated as based on logical operations of abstract reasoning agents (abstract pragmatics). A possible intensional origin of classical logical laws will be examined. Concepts will be approached in first-order and type-theoretical setting as well. One hypothesis to be examined is that intensional logic and logical concepts can be described in terms of objectivity and (according to Gödel’s hypothesis) in terms of causality.2) The intensional nature of some fundamental ontological concepts will be examined on the example of the new formalization of Bolzano’s ontological theory, in comparison Leibniz&#39;s  ontology. The research will focus on the concepts of substance, adherence/inherence, and whole-part.3) The contribution of concepts to the objective value of knowledge is aimed to be shown, especially in mathematics, and starting from Frege’s theory of concepts. Especially, the interrelationship of the conceptual and objectual content in analytic and first-order propositions will be investigated.4) The causal role of logical concepts and language in the context of their use in speech acts and argumentative dialogue will be analysed. Pragmatics will be shown to be an essential constituent part of logic, which is, like syntax and semantics, apt to be rigorously formalized. In addition, the research aims to show that the use of logic and language is a primary source of the description of concepts.]]></summary_en></project><project>
<id>3902</id><title_hr><![CDATA[Poluvodički elementi visokih performansi  za primjene u sklopovima za bežične komunikacije i optičke detektore]]></title_hr><title_en><![CDATA[]]></title_en><user_id>6955</user_id><user_firstLast_name>Tomislav Suligoj</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2015-10</proposal_call><code>DOK-2015-10-6924</code><acronim><![CDATA[HiPerSemi]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Elektrotehnika, </scie_field_hr><scie_field_en>Electrical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id>24097</team_members_id><team_members_names><![CDATA[ Doktorand: Željko Osrečki ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[semicoductors, microelectronics, bipolar transistors, photodetectors, photodiodes, CMOS, modeling, MOSFET, RF circuits]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[The objective of this project is to provide notable scientific contributions by designing and utilizing the advanced semiconductor devices for the wireless communication circuits and solid-state optical detection applications. Research in this project will be grouped in three major activities, which are: (i) Horizontal Current Bipolar Transistor (HCBT) for RF Wireless Circuits, (ii) Characterization and applications of solid-state photodetectors, and (iii) Modelling of MOS, photodetector and other advanced electron devices. The novel wireless RF communication circuits such as mixer, frequency divider, voltage-controlled oscillator, RF switch and power amplifier will be designed and fabricated in HCBT technology as the first such circuits using the HCBT as an active component. The measurements of noise, reliability and on-wafer uniformity as well as linearity, gain and efficiency will be performed on transistors and circuits. The characterization of material properties of pure amorphous boron (PureB) layers will be made in order to determine the composition, electrical and optical properties of the layer and to develop the model of charge carrier transport through it. They will be correlated with electrical measurements to find out currently-unknown physical mechanisms responsible for the current reduction and for the record-high performance of photodides with PureB layers. The investigation of the novel materials such as Ge, SiGe and GaN for ultra-scaled advanced CMOS structures, i.e. FinFETs, will be performed by the development of novel models and simulation environment. The analog/RF parameters and characteristics will be extracted for FinFETs with different geometries and materials in order to determine the optimum structure for future RF systems.]]></summary_en></project><project>
<id>3903</id><title_hr><![CDATA[Napredna 3D percepcija za mobilne robotske manipulatore]]></title_hr><title_en><![CDATA[]]></title_en><user_id>6310</user_id><user_firstLast_name>Robert Cupec</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2015-10</proposal_call><code>DOK-2015-10-2657</code><acronim><![CDATA[ARP3D]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Računarstvo, </scie_field_hr><scie_field_en>Computer sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište Josipa Jurja Strossmayera Osijek, Fakultet elektrotehnike, računarstva i informacijskih tehnologija Osijek]]></institution_hr><institution_en><![CDATA[Josip Juraj Strossmayer University of Osijek, Faculty of Electrical Engineering, Computer Science and Information Technology Osijek]]></institution_en><team_members_id>21326</team_members_id><team_members_names><![CDATA[ Doktorand: Petra Đurović ]]></team_members_names><keywords_hr><![CDATA[računalni vid, robotska manipulacija, prepoznavanje objekata, lokalizacija robota, segmentacija, 3D senzori]]></keywords_hr><keywords_en><![CDATA[computer vision, robot manipulation, object recognition, robot localization, segmentation, 3D sensors]]></keywords_en><summary_hr><![CDATA[Unatoč naglom napretku 3D računalnog vida, još uvijek postoji potreba za učinkovitijim, pouzdanijim i fleksibilnijim sustavima robotske percepcije. Osnovni cilj ovog projekta je razviti nove odnosno unaprijediti postojeće metode 3D robotskog vida za primjenu u zadacima robotske manipulacije. Predloženo istraživanje obuhvaća primjenu 3D senzora za izvođenje prototipnih zadataka koji uključuju manipulaciju objektima u kombinaciji sa samostalnim kretanjem u nestrukturiranoj okolini. Težište istraživanja je na robotskoj percepciji zasnovanoj na 3D oblacima točaka dobivenim 3D senzorima, dok su planiranje kretanja i hvatanja objekata uključeni samo radi evaluacije razvijenih rješenja s područja računalnog vida. Istraživanje će se provoditi u tri smjera: (i) segmentacija oblaka točaka i 3D modeliranje; (ii) prepoznavanje objekata; (iii) lokalizacija mobilnog robota. Radi olakšavanja komunikacije između čovjeka i robota, bit će razvijena metoda segmentacije oblaka točaka, koja će rezultirati modelom okoline u obliku zasebnih objekata relevantnih za mobilnu manipulaciju, što će omogućiti korisniku zadavanje zadataka robotu na jednostavan i intuitivan način. Razvijat će se više novih metoda s primjenom u okviru uobičajene strategije raspoznavanja objekata zasnovanog na značakama s ciljem povećanja računske učinkovitosti uz istovremeno postizanje visoke preciznosti i osjetljivosti (engl. precision and recall). Radit će se na osmišljavanju novih značajki za učinkovito generiranje hipoteza. Također će se razvijati nova metoda procjenjivanja vjerojatnosti generiranih hipoteza. Uz ovaj pristup, istraživat će se i primjena slučajnog evolucijskog algoritma pretraživanja te metode podudaranja grafova u prepoznavanju objekata. Razvijeni sustav prepoznavanja objekata bit će nadograđen i prilagođen za prepoznavanje mjesta u okviru sustava za lokalizaciju mobilnog robota. Sve metode razvijene u okviru projekta ispitat će se pokusima s mobilnim robotskim manipulatorom.]]></summary_hr><summary_en><![CDATA[Despite rapid advancement in 3D computer vision, there is still a need for more efficient, reliable and flexible robot perception systems. The main goal of this project is to develop new or improve existing 3D robot vision methods for application in mobile robot manipulation tasks. The proposed research considers application of 3D sensors in execution of prototypical tasks which include object manipulation combined with autonomous motion in an unstructured environment. The focus of the research is on robot perception based on 3D point clouds obtained by 3D sensors, while motion planning and grasping are involved only for the purpose of evaluation of the developed vision-based solutions. The research will be conducted in three directions: (i) point cloud segmentation and 3D modelling; (ii) object recognition; (iii) mobile robot localization. In order to facilitate human-robot communication, a point cloud segmentation method will be developed which will create environment models in the form of separate geometric objects relevant for mobile robot manipulation, providing a user with a simple and intuitive means of defining robot manipulation tasks. Several novel approaches within the framework of a common feature-based object recognition pipeline will be developed with the purpose of increasing the computational efficiency while achieving a high precision-recall characteristic. Novel features for efficient hypothesis generation will be designed. A novel hypothesis probability estimation approach will be developed. Furthermore, application of a random evolutionary search algorithm and graph matching in object recognition will be investigated. The developed object recognition system will be extended and adapted for place recognition within a mobile robot localization framework. All developed approaches will be evaluated by experiments with a mobile robot manipulation.]]></summary_en></project><project>
<id>3907</id><title_hr><![CDATA[Kooperativno upravljanje iskustvenom kvalitetom u pokretnim mrežama za interaktivne višemedijske aplikacije u računalom oblaku]]></title_hr><title_en><![CDATA[]]></title_en><user_id>3964</user_id><user_firstLast_name>Lea Skorin-Kapov</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2015-10</proposal_call><code>DOK-2015-10-6013</code><acronim><![CDATA[Q-MANIC]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Elektrotehnika, </scie_field_hr><scie_field_en>Electrical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id>21062</team_members_id><team_members_names><![CDATA[ Doktorand: Irena Oršolić ]]></team_members_names><keywords_hr><![CDATA[Iskustvena kvaliteta, modeliranje iskustvene kvalitete, višemedijske aplikacije, računalni oblak, upravljanje iskustvenom kvalitetom]]></keywords_hr><keywords_en><![CDATA[Quality of Experience, QoE modelling, multimedia applications, cloud, QoE management]]></keywords_en><summary_hr><![CDATA[Zbog rasta broja novih pokretnih uređaja poput pametnih telefona i tableta, aplikacije i usluge namijenjene izvođenju na pokretnim uređajima su postale sastavni dio ljudske svakodnevice, sa značajnim utjecajem na ljudsku komunikaciju, učenje i zabavu. Potaknut zahtjevima poput skalabilnosti, fleksibilnosti i administracije, nastavio se trend migracije aplikacija u računalni oblak. Ono što i dalje ostaje ključni problem i razlikovno sredstvo između pružatelja usluga je ispunjavanje zahtjeva krajnjih korisnika s obzirom na očekivanu kvalitetu usluge, a što se naziva iskustvenom kvalitetom (QoE). Projekt Q-MANIC predložit će kooperativnu shemu za upravljanje iskustvenom kvalitetom, iskorištavajući nova znanja o iskustvenoj kvaliteti i poslovne modele usredotočene na kooperativne napore pružatelja usluga/usluga zasnovanih na računalnom oblaku i davatelja usluga u pokretnim mrežama kako bi se ostvarilo efikasnije upravljanje mrežnim resursima, a pritom i poboljšala iskustvena kvaliteta krajnjeg korisnika. Pored postojećih načina razmjene informacija u današnjim mrežama, bit će predloženi novi pristupi za koordinaciju i razmjenu informacija između aktora u postojećem vrijednosnom lancu pružatelja usluga. Bit će predloženi novi načini raspodjele resursa i novi algoritmi za prilagodbu usluge koji imaju u vidu različite strategije optimizacije. Kako bi pokazali korist i primjenjivost predloženog pristupa, prikazat ćemo dva slučaja uporabe koji predstavljaju primjer visoko interaktivnih i mrežno zahtjevnih višemedijskih aplikacija koje su dostavljaju putem pokretnih mreža (LTE/LTE-advanced/5G): usluga igranja u pokretu zasnovana na računalnom oblaku i usluga višekorisničkog video razgovora u pokretu. Oslonit ćemo se empirijski dobivene podatke kako bi specificirali modele iskustvene kvalitete i optimalne strategije za prilagodbu usluge. Shema za upravljanje iskustvenom kvalitetom koristit će mehanizme za upravljanje mrežom i strategije za prilagodbu aplikacije kako bi se poboljšala iskustvena kvaliteta i povećala efikasnost zauzeća resursa. Ključni doprinos bit će ugradnja kontekstualnih znanja i rezultata analize korisničkog ponašanja i interakcije u validirani model iskustvene kvalitete koji će biti korišten za efikasno upravljanje iskustvenom kvalitetom.]]></summary_hr><summary_en><![CDATA[With the proliferation of new mobile devices such as smartphones and tablets, mobile applications have become an integral part of our daily life activities, with a profound impact on the way people communicate, learn, or entertain. Driven by requirements such as scalability, flexibility, and administration, there is an increasing trend in migrating applications to the cloud. A key concern and differentiator between providers is meeting end users’ requirements in terms of service quality and expectations, referred to as Quality of Experience (QoE). The Q-MANIC project will propose a cooperative QoE management scheme exploiting new QoE knowledge and business models based on cooperative efforts between cloud/service providers and mobile network operators to achieve more efficient management of network/system resources, while enhancing end user QoE. Novel approaches for coordination and information exchange among actors involved in the service delivery chain will be proposed beyond those available in today&#39;s networks. Resource allocation and service adaptation algorithms will be proposed targeting different optimization strategies and taking into account multiple stakeholder perspectives. To demonstrate the benefits and applicability of the proposed approach, we address two use cases involving interactive, bandwidth intensive cloud-based applications delivered via mobile networks (LTE/LTE-advanced/5G): mobile cloud gaming and mobile multi-party video chat. We will rely on empirically obtained data to specify QoE models and optimal service adaptation strategies. The QoE management scheme will combine network management mechanisms and application adaptation strategies to bring improvements in QoE and efficiency of resource usage. A key contribution will be the incorporation of contextual knowledge and analysis of user behaviour and interactions into building validated QoE models that will be exploited in the context of QoE management.]]></summary_en></project><project>
<id>3909</id><title_hr><![CDATA[Non-Foster Source-load Networks and Metasurfaces (NOFSLO) ]]></title_hr><title_en><![CDATA[]]></title_en><user_id>18913</user_id><user_firstLast_name>Silvio Hrabar</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2015-10</proposal_call><code>DOK-2015-10-3888</code><acronim><![CDATA[]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Elektrotehnika, </scie_field_hr><scie_field_en>Electrical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id>24468</team_members_id><team_members_names><![CDATA[ Doktorand: Leo Vincelj ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>3910</id><title_hr><![CDATA[Arheologija jadranske brodogradnje i plovidbe]]></title_hr><title_en><![CDATA[]]></title_en><user_id>5521</user_id><user_firstLast_name>Irena Radić Rossi</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2015-10</proposal_call><code>DOK-2015-10-9657</code><acronim><![CDATA[AdriaS]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Arheologija, </scie_field_hr><scie_field_en>Archeology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zadru]]></institution_hr><institution_en><![CDATA[University of Zadar]]></institution_en><team_members_id>18977</team_members_id><team_members_names><![CDATA[ Doktorand: Katarina Batur ]]></team_members_names><keywords_hr><![CDATA[arheologija broda, brodogradnja, plovidba, Jadransko more, 3D modeliranje, podvodna robotika, povijest tehnologije]]></keywords_hr><keywords_en><![CDATA[nautical archaeology, shipbuilding, seafaring, Adriatic Sea, 3D modellin, underwater robotics, history of technology]]></keywords_en><summary_hr><![CDATA[Osnovni cilj projekta je potencirati sustavno interdisciplinarno proučavanje i interpretaciju arheoloških i povijesnih svjedočanstava o istočnojadranskoj brodogradnji i plovidbi. Bogata jadranska pomorska povijest, promatrana sa stanovišta tehnološkog razvoja drvene brodogradnje i plovidbe kroz vrijeme,  nije se donedavno sustavno proučavala zbog nedostatka odgovarajućih sredstava i solidne metodološke osnove. Projekt uzima u obzir kognitivne i praktične sljedove tehnološkog razvoja brodogradnje i plovidbe, proučavajući međusobne odnose tehnologije s jedne, te političkog, ekonomskog i kulturno-povijesnog konteksta s druge strane. Usredotočen je na problematiku iz svih vremenskih razdoblja ljudske prošlosti (prapovijest, antika, srednji vijek i rani novi vijek) putem aktivnog terenskog rada, arhivskog istraživanja i eksperimentiranja u području virtualne stvarnosti. Počevši od problematike ilirskih lemba i liburnskih liburna, do složene problematike velikih kasnorenesansnih trgovačkih brodova, on pruža sveobuhvatan pregled postignuća dosegnutih u prošlosti, te u hrvatsku znanost uvodi sustavan metodološki pristup proučavanju brodskih konstrukcija. Oslanjajući se na stanje istraživanja u području arheologije broda i pomorske povijesti na svjetskoj razini, projekt ima za cilj uvesti najsuvremenije metode proučavanja starih brodova, njihove opreme i tereta. On potiče inovativan interdisciplinarni pristup u procesu istraživanja, dokumentiranja i interpretacije najznačajnijih izravnih materjalnih svjedočanstava o istočnojadranskoj pomorskoj povijesti, promovirajući međunarodnu suradnju i umrežavanje među mladim znanstvenicima. Takav koncept stvorit će velik potencijal za čitavu zajednicu i potaknuti širi interes javnosti, naročito putem promidžbe projekta u javnim medijima i korištenja generiranog znanja u hrvatskoj turističkoj promociji. ]]></summary_hr><summary_en><![CDATA[The aim of the project is to enhance systematic interdisciplinary study and interpretation of the archaeological and historical record of shipbuilding and seafaring in the Eastern Adriatic. Its rich maritime history, seen through the technological development of wooden shipbuilding and seafaring and the dynamics that affected them over time, has not been systematically researched until recently, due to the lack of appropriate resources and the absence of a sound methodological basis. The project considers the cognitive and practical sequences of the technological development of shipbuilding and seafaring, studying the relationship between technology on one hand and the political, economic and cultural/historical context on the other. It focuses on issues from all periods of the human past (Prehistory, Classical Antiquity, Middle Ages and Early Modern period) through active fieldwork, archival research and virtual reality experimentation. From the problematic histories of the Illyrian lemboi and Liburnian liburnae, to the complex issues of the large late Renaissance merchantmen, it provides a comprehensive overview of the past achievements, and introduces into Croatian research the systematic methodological approach to the study of the ships’ hulls. Taking into consideration global state-of-the-art practices in the fields of nautical archaeology and maritime history, the project aims to introduce cutting edge methodologies of study of ancient ships, their equipment and cargoes. It will foster an innovative interdisciplinary approach in the process of research, recording and interpretation of the most significant direct material evidence of the Eastern Adriatic maritime past, while promoting international collaboration and networking among young researchers. Such concept will have great potential for community outreach and wider public interest, especially through promoting project in public media as well as using new knowledge in Croatian touristic promotion.]]></summary_en></project><project>
<id>3912</id><title_hr><![CDATA[Kristalno inženjerstvo višekomponentnih metaloorganskih materijala povezanih halogenskom vezom: ususret supramolekulskom ugađanju strukture i svojstava]]></title_hr><title_en><![CDATA[]]></title_en><user_id>356</user_id><user_firstLast_name>Dominik Cinčić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2015-10</proposal_call><code>DOK-2015-10-4282</code><acronim><![CDATA[CrystEngMOM]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, </scie_field_hr><scie_field_en>Chemistry, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>21344</team_members_id><team_members_names><![CDATA[ Doktorand: Katarina Lisac ]]></team_members_names><keywords_hr><![CDATA[Halogenska veza, metaloorganski materijali, kokristali, supramolekulska kemija, mehanosinteza]]></keywords_hr><keywords_en><![CDATA[Halogen bond, metal-organic materials, cocrystals, supramolecular chemistry, mechanosynthesis]]></keywords_en><summary_hr><![CDATA[Glavni cilj predloženog istraživanja je razvijanje općeg principa priprave višekomponentnih kristalnih materijala (kokristala) ugodivih svojstava koji sadrže metaloorganske jedinice povezane halogenskim vezama. Ciljana sinteza kokristala metaloorganskih spojeva s donorima halogenske veze predstavljala bi značajan doprinos ne samo kristalnom inženjerstvu već i kemiji materijala te supramolekulskoj kemiji krutina. Predloženo istraživanje otvorit će put ka sintezi novih supramolekulskih krutina kontrolirane strukture i dimenzionalnosti sastavljenih od metaloorganskih jedinica. Takvi materijali mogu imati magnetska, optička i električna svojstva različita od svojstava organskih supramolekulskih materijala. Uz temeljne spoznaje o povezivanju metaloorganskih spojeva halogenskim vezama, proučit će se mogućnost primjene takovog povezivanja u ciljanoj sintezi fotoosjetljivih materijala, navlast kokristala sposobnih prevoditi svjetlostnu energiju u mehaničku. Drugi dio predloženog projekta bit će dizajn i sinteza organskih višekomponentnih materijala povezanih halogenskim vezama. Do sada je izučavanje halogenskih veza bilo osjetno ograničeno jednoličnošću dostupnih donora halogenske veze. Predložena istraživačka skupina spaja iskustva pojedinih suradnika u kovalentnoj sintezi, koordinacijskoj kemiji te kristalnim inženjerstvu, što će omogućiti sintezu kako novih donora halogenske veze, tako i metaloorganskih akceptora te supramolekulskih krutina. Ti će spojevi omogućiti temeljno istraživanje sintonâ halogenske veze, te izučavanje pouzdanih načina izrade proširenih metaloorganskih materijala povezanih halogenskim vezama i mogućnosti priprave izostrukturnih metaloorganskih kokristala radi ugađanja svojstava materijala unošenjem samo malih promjena u zadanu arhitekturu kokristala.]]></summary_hr><summary_en><![CDATA[The principal aim of the proposed research is to develop the first general designs for the assembly of functional multicomponent crystalline materials (cocrystals) involving metal-organic units organized by way of halogen-bonding interactions. The controlled and deliberate synthesis of halogen-bonded cocrystals involving metal-organic building blocks remains an outstanding challenge of crystal engineering, materials science and solid-state supramolecular chemistry. The proposed research will open a path to synthesize new molecular materials with controlled 1-, 2- or 3-D architectures, involving metal-organic building blocks which are expected to provide access to new magnetic, optical and electrical properties not usually available in carbon-based supramolecular networks. In particular, besides establishing the fundamental aspects of the design of halogen-bonded metal-organic materials, the proposed research will explore the application of these designs in the synthesis of photoresponsive switching materials, specifically of cocrystals capable of transforming light into mechanical motion. Another element of the proposed research project will be the design and synthesis of purely organic halogen-bonded multi-component materials. The field of halogen-bonded cocrystals has so far been heavily limited by the poor availability of diverse halogen bond donor building blocks. A particular strength of the assembled research team lies in the extensive experience in covalent synthesis, coordination chemistry and crystal engineering, enabling the synthesis of new halogen bond donors of different bonding strength and directionality, which will be employed for the fundamental studies of halogen bonding synthons, of reliable strategies for the construction of extended halogen bonded metal-organic materials, and of isostructural metal-organic cocrystals as a means to fine-tune the properties of solid materials by introducing minute differences into a given cocrystal architecture.]]></summary_en></project><project>
<id>3913</id><title_hr><![CDATA[Razvoj naprednih energetski učinkovitih struktura upravljanja generatorom sa stalnim magnetima bez mjernog člana ]]></title_hr><title_en><![CDATA[]]></title_en><user_id>5949</user_id><user_firstLast_name>Damir Sumina</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2015-10</proposal_call><code>DOK-2015-10-4739</code><acronim><![CDATA[PMGEFC]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Elektrotehnika, </scie_field_hr><scie_field_en>Electrical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id>22617</team_members_id><team_members_names><![CDATA[ Doktorand: Filip Jukić ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[permanent magnet generator,  wind power generation, back-to-back converter, energy efficiency,  sensorless control,]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Renewable energy sources have been attracting great attention due to the cost increase, limited reserves and advanced environmental impact on fossil fuels. In the meantime, technology advancements, cost reduction and governmental incentives have made some renewable energy sources more competitive in the market. Among them, wind energy is the one of the fastest growing renewable energy sources. The conversion of the wind energy into electric energy is of a multidisciplinary nature, involving aerodynamics, mechanical systems, electric machines, power electronics, control theory, and power systems.The main goal of this project is to establish new research group which will improve the quality, performance and competitiveness of industrial sector in the field of wind power generation. The research group has already participated in the project for the development of advanced control structures for induction generator connected via back-to-back-converter to the grid in wind turbine application. As a step forward in innovation, research and development the research focus is set on permanent magnet synchronous generator (PMG) parameter identification, estimation of PMG rotor position using high frequency signal injection and speed estimation. Also, focus is on energy efficient based control method such as model predictive control of PMG. Advanced sensorless control algorithms for PMG will be developed and experimentally verified on the industrial laboratory model. Basic infrastructure for implementation and verification of developed algorithms exists in the Laboratory and for testing of advanced control structures on PMG laboratory model needs to be further upgraded. The final result will be the capability of research group for future cooperation with industrial partners for development of wind power generator systems and other generation systems.]]></summary_en></project><project>
<id>3914</id><title_hr><![CDATA[MAtematička analiza multifizikalnih problema koji uključuju tanke i kompozitne strukture i fluide]]></title_hr><title_en><![CDATA[]]></title_en><user_id>6764</user_id><user_firstLast_name>Igor  Velčić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2015-10</proposal_call><code>DOK-2015-10-6985</code><acronim><![CDATA[MAMPITCoStruFl]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Matematika, </scie_field_hr><scie_field_en>Mathematics, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id>23191</team_members_id><team_members_names><![CDATA[ Doktorand: Josip Žubrinić ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[thin structures, composite structures, dimensional reduction, homogenization, Gamma convergence, fluid-structure interaction, existence of solution ]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Composite materials are materials made from two or more constituent materials with different physical properties that, when combined, produce a material with characteristics different from those of its individual components. Thin and composite structures are of extreme importance for applications in engineering (e.g. building blocks, boats, ships, aircraft design) and biology (bones, biological tissues, blood vessels) where they are often subjected to fluid load. The analysis of these kind of complex multi-physics systems is very challenging from the mathematical point of view. Namely, the analysis of thin and composite structures and fluids includes the analysis of nonlinear partial differential equations (nonlinear PDEs), which leads to interesting mathematical questions (Gamma limits of a certain system of nonlinear equations with highly oscillating coefficients, existence for a certain system of nonlinear PDEs). This project plans the following: derivation of lower dimensional models in elasticity for highly oscillating materials, optimal design problems, derivation and analysis of fluid-structure interaction problems (derivation of coupling conditions, well-posedness and asymptotic stability analysis). We will use both Calculus of Variation and PDEs techniques to approach different topics, using the benefits from both. We strongly believe that this diversity will bring additional value to Croatian applied mathematics and will provide young people to develop and get acquainted with different approaches of the modern applied mathematics.]]></summary_en></project><project>
<id>3917</id><title_hr><![CDATA[Multidisciplinary Metrics for Soldier Resilience Prediction and Training]]></title_hr><title_en><![CDATA[]]></title_en><user_id>18918</user_id><user_firstLast_name>Krešimir Ćosić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2015-10</proposal_call><code>DOK-2015-10-6899</code><acronim><![CDATA[]]></acronim><duration>19.10.2016 - 03.04.2022</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Računarstvo, </scie_field_hr><scie_field_en>Computer sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id>22772</team_members_id><team_members_names><![CDATA[ Doktorand: Ivan Kesedžić ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>3921</id><title_hr><![CDATA[Energetski učinkovit asinkroni bežični prijenos]]></title_hr><title_en><![CDATA[]]></title_en><user_id>6379</user_id><user_firstLast_name>Tomislav Matić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2015-10</proposal_call><code>DOK-2015-10-4897</code><acronim><![CDATA[EEAWT]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Elektrotehnika, </scie_field_hr><scie_field_en>Electrical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište Josipa Jurja Strossmayera Osijek, Fakultet elektrotehnike, računarstva i informacijskih tehnologija Osijek]]></institution_hr><institution_en><![CDATA[Josip Juraj Strossmayer University of Osijek, Faculty of Electrical Engineering, Computer Science and Information Technology Osijek]]></institution_en><team_members_id>13497</team_members_id><team_members_names><![CDATA[ Doktorand: Leon Šneler ]]></team_members_names><keywords_hr><![CDATA[bežični prijenos, asinkrona analogno-digitalna pretvorba, ultra-širokopojasni modulacijski postupci, bežične senzorske mreže, internet objekata]]></keywords_hr><keywords_en><![CDATA[wireless transmission, asynchronous analog-to-digital conversion, ultra-wideband modulation techniques, wireless sensor networks, internet of things]]></keywords_en><summary_hr><![CDATA[Kako bi se postigla energetska učinkovitost i smanjila površina integriranih sklopova za bežični prijenos, u posljednje se vrijeme primjenjuju asinkroni dizajn i širokopojasni modulacijski postupci. Veliki izazov pri projektiranju asinkronog bežičnog prijenosa je detekcija signala na strani prijemnika i uspostava više-korisničkog prijenosa. Prijedlog istraživačkih aktivnosti u sklopu ovog projekta je izrada energetski učinkovitih asinkronih integriranih sklopova za bežični prijenos analognog signala primjenjivih u senzorskim čvorovima bežičnih senzorskih mreža. Predloženi sustav se može podijeliti na dva podsustava, analogno-digitalni pretvornik i modulator za bežični prijenos. Na taj se način projektne aktivnosti mogu podijeliti u dvije faze. Prva faza uključuje izradu asinkronog analogno-digitalnog pretvornika, dok druga faza uključuje aktivnosti u izradi modulatora temeljenog na ultra-širokopojasnom (UWB) generatoru impulsa. Za izradu analogno-digitalnog pretvornika primjenjivat će se asinkroni sigma-delta modulator i različite tehnike temeljene na detekciji razine signala, dok će se za izradu UWB modulatora razmatrati modulacijske tehnike za digitalne ulazne signale. Zbog jako uskog impulsa i načina rada s iznimno niskim faktorom ispune, UWB modulacijski postupci su atraktivan izbor za energetski učinkovit bežični prijenos. Razvoj postojećih i izrada novih širokopojasnih modulacijskih postupaka u sklopu ovog projekta provodit će se s ciljem postizanja energetske učinkovitosti. Kako bi se zadovoljili osnovni ciljevi energetske i površinske učinkovitosti, prijenosni sustav će biti izrađen u CMOS procesu.]]></summary_hr><summary_en><![CDATA[To achieve high circuit power and size efficiency in wireless transmission circuits, recent contributions propose asynchronous design and spread spectrum communications. A great challenge in asynchronous wireless transmission is to accomplish signal detection at the receiver side and to establish multiuser transmission. The proposal of research activities in this project will be the design of low power asynchronous circuits for wireless transmission of analog input signals applicable as sensor nodes in short distance wireless sensor networks. The proposed system can be divided into two major subsystems consisting of the analog-to-digital (A/D) converter and the modulator for wireless transmission. Hence, the project activities can be divided into two major phases. The first phase will include asynchronous ADC design, where novel circuit architectures will be investigated, while the second phase will include activities on the modulator design incorporating ultra-wideband (UWB) pulse generators. The asynchronous sigma-delta modulator and various level crossing schemes will be investigated for A/D conversion, while UWB modulation techniques will be considered for the digitized signal modulation. Due to narrow pulse width and duty-cycled operation, UWB modulation techniques are a reasonable choice for the energy efficient wireless transmission. Evaluation of existing and development of new spread spectrum modulation techniques will be carried out to improve energy efficiency. To satisfy the major size and power consumption requirements, the transmission circuitry will be designed in CMOS process.]]></summary_en></project><project>
<id>3922</id><title_hr><![CDATA[Pametna okruženja za poboljšanje kvalitete života]]></title_hr><title_en><![CDATA[]]></title_en><user_id>3685</user_id><user_firstLast_name>Mladen Russo</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2015-10</proposal_call><code>DOK-2015-10-1241</code><acronim><![CDATA[ELISE]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Elektrotehnika, </scie_field_hr><scie_field_en>Electrical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Splitu, Fakultet elektrotehnike, strojarstva i brodogradnje]]></institution_hr><institution_en><![CDATA[University of Split, Faculty of Electrical Engineering, Mechanical Engineering and Naval Architecture]]></institution_en><team_members_id>21298</team_members_id><team_members_names><![CDATA[ Doktorand: Luka Kraljević ]]></team_members_names><keywords_hr><![CDATA[pametne okoline, nosiva sučeljam računalni vid, proširena stvarnost, prepoznavanje govora, prikupljanje energije iz okoline, lokalizacija, zv. kulise]]></keywords_hr><keywords_en><![CDATA[smart environments, wearable interfaces, computer vision, augmented reality, speech recognition, ambient energy harvesting, localization, soundscaping]]></keywords_en><summary_hr><![CDATA[Pametna okolina predstavlja svijet pun različitih senzora i pametnih uređaja koji neprimjetno rade skupa, čineći svakodnevni život lakšim i udobnijim. Projekt ELISE je zamišljen kao interdisciplinarni istraživački pristup usmjeren ka poboljšanju tehnologija na kojima se temelje pametne okoline, s ciljem uspostavljanja okvira za razvoj raznih real-life usluga i aplikacija u pametnim okolinama. Glavna područja istraživanja će uključivati senzore niske potrošnje i prikupljanje energije iz okoline, nosiva sučelja, prepoznavanje govora, računalni vid, prepoznavanje objekata i teksta, proširenu stvarnost, lokalizacijske tehnologije, zvučne kulise i auralizaciju. Svi članovi našeg interdisciplinarnog tima su visoko kvalificirani stručnjaci u tim područjima, budući da su već objavili doktorske disertacije i visoko kvalitetne radove u predloženim područjima istraživanja. Projekt će također doprinijeti obuci dva nova doktoranda omogućujući im odlične uvjete za njihova istraživanja. Istraživanja u svim područjima će se temeljiti na integriranom pristupu s vizijom razvoja real-life aplikacija u pametnoj okolini. Osobito dvije aplikacije će usmjeravati naš rad, te su planirane za izradu prototipa i demonstraciju u posljednjim fazama projekta: Smart sightseeing (Pametno razgledavanje) i Smart museum tour (Pametna tura muzejom). Temeljit će se na sučelju proširene stvarnosti (Augmented Reality – AR) na način da će se objekti od interesa automatski prepoznavati te omogućiti predstavljanje dodatnih sadržaju korisniku, također će biti opremljeni modulom za lokalizaciju, imati mogućnost poboljšanja AR pomoću zvučnih kulisa, biti upravljani pomoću govora i pametnih nosivih sučelja, npr. sučelje za prepoznavanje pokreta ruku, uz sposobnost detektiranja korisnikovih emocionalnih stanja i prilagođavanja sadržaja sukladno tome. Razvijeni moduli također će tvoriti osnovu za razvoj drugih aplikacija za lakši život u pametnim okolinama, uključujući domove, bolnice, ustanove za brigu o starijima i nemoćnima, uredima, gradovima...]]></summary_hr><summary_en><![CDATA[Smart environment represents a world full of different sensors and smart devices seamlessly working together, making everyday living easier and more comfortable. ELISE is envisioned as an interdisciplinary research approach aimed for improving the technologies on which smart environments are based, with the goal of establishing a framework for developing various real-life services and applications in smart environments. Primary areas of research will include low power sensing and ambient energy harvesting, wearable interfaces, speech recognition, computer vision, object and text recognition, augmented reality, localization technologies, soundscaping and auralization. All members of our interdisciplinary team have skills and experience in these areas since their PhD theses and published papers are directly related to the proposed research. ELISE will also contribute to the training of two new PhD students providing excellent conditions for their research. Research in all areas will be based on integrated approach with a vision of developing real-life smart environment applications. Particularly two applications will drive our work and are planned for prototyping and demonstration in the last stages of the project: smart sightseeing and smart museum tour. They will be based on augmented reality interface in a way that objects of interest are recognized in the scenes enabling presentation of additional content to the user, they will be equipped will localization module, have the ability of soundscape to enhance AR, be controlled via speech and wearable smart interfaces, e.g. hand gesture recognition interface, with the ability of detecting user&#39;s emotional states and adapting the content accordingly. Developed modules will also form the basis for developing other applications for easier living in smart environments, including homes, hospitals, care facilities, offices, cities...]]></summary_en></project><project>
<id>3925</id><title_hr><![CDATA[Mjerenje svojstava Higgsovog bozona i potraga za novom fizikom detektorom CMS]]></title_hr><title_en><![CDATA[]]></title_en><user_id>6738</user_id><user_firstLast_name>Ilja Doršner</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2015-10</proposal_call><code>DOK-2015-10-6865</code><acronim><![CDATA[HIGGSPRO]]></acronim><duration></duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, </scie_field_hr><scie_field_en>Physics, </scie_field_en><institution_hr><![CDATA[Sveučilište u Splitu, Fakultet elektrotehnike, strojarstva i brodogradnje]]></institution_hr><institution_en><![CDATA[University of Split, Faculty of Electrical Engineering, Mechanical Engineering and Naval Architecture]]></institution_en><team_members_id>22637</team_members_id><team_members_names><![CDATA[ Doktorand: Toni Vrdoljak ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[CMS detector, LHC, Higgs boson, leptoquarks, electron reconstruction]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[The discovery of a Higgs boson by the ATLAS and CMS experiments at the LHC has opened a new era for particle physics, namely precision consistency tests of the SM Higgs boson. The proposed project has two main goals: measurement of the SM Higgs boson properties, as the window for the search for new physics beyond the Standard model, and a direct search for new physical phenomena looking for hypothetical particles called leptoquarks. In the first year of project we will explore the data collected by the CMS experiment during 2011 and 2012, while preparing for the LHC Run II, which is expected to start in 2015. Preparation consists of developing and implementing new electron reconstruction, identification and isolation algorithms, which will be used by the whole collaboration when the new data taking starts.  During the second year of the project we will commission and maintain electron reconstruction algorithms, start collecting the data and make first analysis at new energy. During third and fourth year we will explore the data and concentrate to the two main goals of the project: SM Higgs boson properties measurements and search for new physics. ]]></summary_en></project><project>
<id>3929</id><title_hr><![CDATA[Jako korelirani elektroni u slojnim organskim materijalima i manganitima: niskofrekventna pobuđenja i nelinearna dinamika]]></title_hr><title_en><![CDATA[]]></title_en><user_id>3184</user_id><user_firstLast_name>Tomislav Ivek</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2015-10</proposal_call><code>DOK-2015-10-1547</code><acronim><![CDATA[SCEinLOM]]></acronim><duration>16.10.2017 - 16.02.2022</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, </scie_field_hr><scie_field_en>Physics, </scie_field_en><institution_hr><![CDATA[Institut za fiziku]]></institution_hr><institution_en><![CDATA[Institute of Physics in Zagreb]]></institution_en><team_members_id>23242</team_members_id><team_members_names><![CDATA[ Doktorand: Željko Rapljenović ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[correlated electrons, unconventional superconductivity, colossal magnetoresistance, charge and spin orderings, quantum spin liquids, nonlinear effects]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[Strongly correlated electrons in solids generate broken symmetry phases and collective excitations that are fundamental to our understanding of the most intriguing properties of quantum matter. Phase diagrams of layered cuprate, organic superconductors and manganites, as well as some other transition-metal systems, famous for the phenomena of unconventional superconductivity (SC) and colossal magnetoresistance (CMR), respectively feature an extraordinary complexity of electronic phases, which can be tuned by chemical composition, magnetic field and pressure. A prominent place among these phases is held by stripes, patterns of charge order (CO), which are thought to be linked to SC and CMR, as well as by CO phases with ferroelectric signatures due to a rich variety of nonlinear properties and complex dynamics. Despite intense research efforts, these basic issues in condensed matter physics bear many open questions. We propose to investigate the nature of charge/spin-ordered phases and their motion developed in series of organic and transition metal solids applying modern experimental tools available at the Institute of Physics, Zagreb and at the Department of Physics, Faculty of Science, University of Zagreb (dielectric spectroscopy, pulsed nonlinear conductivity, ac/dc resistance, magnetoresistance and Hall effect).  Our overall contributions to the field and our expertise in condensed matter physics have been internationally recognized. Together with the available experimental means, this positions us as researchers fully suitable and competent for the proposed task. Our international partners will give an added value with samples, experiments and expertise in the terahertz and infrared spectroscopy. Integrated students and postdocs are going to acquire advanced skills in the materials science and learn to solve complex problems in a collaborative environment. Results will be published in international scientific journals and presented at international conferences.]]></summary_en></project><project>
<id>4025</id><title_hr><![CDATA[Imunosni mehanizmi u razvoju upale i metaboličkog sindroma u debljini]]></title_hr><title_en><![CDATA[Immune mechanisms in development of inflammation and metabolic syndrome in obesity]]></title_en><user_id>7082</user_id><user_firstLast_name>Bojan Polić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2016-06</proposal_call><code>IP-2016-06-9306</code><acronim><![CDATA[INFLAMETAB]]></acronim><duration>01.06.2017 - 31.10.2021</duration><status>Završio</status><financ_value>132.532,75 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, Kliničke medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, Clinical sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Medicine]]></institution_en><team_members_id>19737, 19670, 19638, 19824, 4999, 25199, 25607, 856077, </team_members_id><team_members_names><![CDATA[Marko Šestan, Sonja Valentić, Tamara Turk Wensveen, Marko Zelic, ĐURĐICA CEKINOVIĆ, Ante Benić, Valentina Obadić, Sanja Mikašinović, ]]></team_members_names><keywords_hr><![CDATA[Upala, Debljina, Rezistencija na inzulin, metabolički sindrom, diabetes, NASH,  stanice NK, urođeni limfociti, gamma delta limfociti T, citokini]]></keywords_hr><keywords_en><![CDATA[Inflammation, Obesity, Insuline resistance, Metabolic Syndrome, diabetes, NASH, NK cells, ILCs, gamma delta T cells, macrophages, cytokines]]></keywords_en><summary_hr><![CDATA[Pretilost je jedan od najznačajnijih i rastućih medicinskih zdravstvenih problema današnjice. Procjenjuje se da trenutno na svijetu živi više od pola milijarde debelih ljudi i  preko milijarde onih s prekomjernom težinom. Značajan broj njih oboljeva od šećerne bolesti tipa 2 (DM2) i nealkoholne bolesti masne jetre (NAFLD), koje često koegzistirjau i dijele patogene abnormalnosti debljine kao što su rezistencija na inzulin (IR), dislipidemija i hipertenzija, što su karakteristike metaboličkog sindroma. Debljina je povezana sa kroničnom sistemskom upalom niskog intenziteta za koju se smatra da je važan pozadinski uzrok IR, koja dovodi do DM2 i NAFLD. Ciljanje mehanizama upale u obje bolesti je stoga obećavajuće za buduće pristupe u terapiji. No, stvarni mehanizmi koji induciraju ili pogoršavaju upalu u debljini i uzrokuju prijelaz iz stadija pre-dijabetesa u DM2 ili iz stadija jetrene steatoze u nealkoholni steatohepatitis (NASH) su još uvjek uglavnom nejasni. Stoga je bolje poznavanje imunosnih uzroka DM2-a i NASH-a neophodno potrebno. U ovom projektu namjeravamo istražiti imunosne mehanizme koji su važni za indukciju upalnih procesa u visceralnom masnom tkivu (VAT) i jetri, te su odgovorni za razvoj DM2 i NASH. Dodatno, naš cilj je istražiti virusne faktore koji pogoršavaju IR i imaju učinak na tranziciju iz pre-dijabetesa u DM2. U ovoj studiji koristi ćemo dobro pozate mišje modele dijetom inducirane debljine (DIO), te odgovarajuće mišje mutante i druga oruđa kako bismo odgovorili na postaljena pitanja. Isto tako, usporediti ćemo eksperimentalne podatke sa podacima analize uzoraka sakupljenih od pretilih bolesnika što je također planirano projektom. Ovaj projekt povezuje imunologiju, virologiju i endokrinologiju. Istraživački tim ima dovoljno iskustva i znanja za uspješno provođenje predloženog istraživanja, te će bti sposoban stvoriti nova vrijedna i korisna saznanja o razvoju DM2-a i NASH-a. ]]></summary_hr><summary_en><![CDATA[Obesity is one of the most prominent and growing health problem of our time. It is estimated that more than a half billion of obese and another billion of overweight people live currently in the world. A significant number of them develop Diabetes Mellitus type 2 (DM2) and Non-alcoholic Fatty Liver Disease (NAFLD), which often coexist and share pathogenic abnormalities of obesity like insulin resistance (IR), dyslipidaemia and hypertension, which are features of the metabolic syndrome. Obesity is associated with a chronic systemic low-grade inflammation which is thought to be an important underlying cause of IR that leads to DM2 and NAFLD. Targeting of the underlying mechanisms of inflammation in both diseases therefore holds much promise for future therapies. However, the exact mechanisms that induce or aggravate inflammation and trigger transition from pre-diabetes to DM2 or from hepatic steatosis to non-alcoholic steatohepatitis (NASH) in obesity are still largely unclear. A better understanding of immunological causes of DM2 and NASH is therefore required.In this project we aim to investigate immune mechanisms that are important for induction of inflammatory processes in visceral adipose tissue (VAT) and liver, which are responsible for development of DM2 and NASH. In addition, our goal is to investigate viral factors that aggravate IR such as impact progression from pre-diabetes to DM2. In our study we will use well established mouse models of diet induced obesity (DIO) and appropriate mouse mutants and tools to address raised questions. We will compare experimental data with the analysis of samples collected from obese human subjects also planned in the project. Our project bridges immunology, virology and endocrinology. Our team has enough experience and expertise to drive successfully proposed research and will be able to provide valuable new insights in the development of DM2 and NASH. ]]></summary_en></project><project>
<id>4026</id><title_hr><![CDATA[Genetsko poboljšanje i optimizacija potencijala rodnosti pšenice]]></title_hr><title_en><![CDATA[Genetic improvement and optimization of wheat yield potential]]></title_en><user_id>7647</user_id><user_firstLast_name>Dario Novoselović</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2016-06</proposal_call><code>IP-2016-06-2178</code><acronim><![CDATA[GI OPTI WHEAT]]></acronim><duration>01.03.2017 - 30.06.2021</duration><status>Završio</status><financ_value>125.024,89 eur</financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Poljoprivreda, </scie_field_hr><scie_field_en>Agriculture, </scie_field_en><institution_hr><![CDATA[Poljoprivredni institut Osijek]]></institution_hr><institution_en><![CDATA[Agricultural Institute Osijek]]></institution_en><team_members_id>19238, 19287, 19286, 19239, 1248, 19311, 19397, 825, 1259, 7754, 19290, 19509, 19688, 5095, 20111, 7747, 20271, 20332, 23241, 25033, 25332, </team_members_id><team_members_names><![CDATA[Sonja Grljušić, Georg Drezner, Krešimir Dvojković, Brigita  Popović, Jasenka Ćosić, Marko Maričević, Meri Engler, Daniela Horvat, Karolina Vrandečić, Hrvoje Šarčević, Ana Lovrić, Nikolina Šimić, Zoran Užila, Gordana Šimić, Ivica Ikić, Zdenko Lončarić, Alison Bentley, Ian Mackay, Marko Ivić, Ivana Plavšin, Magdalena Matić, ]]></team_members_names><keywords_hr><![CDATA[pšenica, urod, kvaliteta, zrno, dušik, Fusarium,  ]]></keywords_hr><keywords_en><![CDATA[wheat, yield, quality, grain, nitrogen, Fusarium, ]]></keywords_en><summary_hr><![CDATA[Današnji i budući zahtjevi za pšenicom u svijetu zahtijevaju korištenje niza novih pristupa u povećanju prinosa pšenice kako u svijetu tako i u regiji. Najizravnije i najočitije rješenje za ove izazove je kroz povećanje produktivnosti usvajanjem germplazme pšenice povećanog genetskog potencijala rodnosti i adaptabilnosti u različitim proizvodnim uvjetima. Prema tome, glavni ciljevi ovog projektnog prijedloga su: 1. fenotipizacija i karakterizacija elitne germplazme pšenice iz regije za najvažnija agronomska svojstva i svojstva kvalitete, svojstva vezanih uz NUE (nitrogen use efficiency), te tolerantnosti na najvažnije biotske stresove kao što je fuzarijska palež klasa u različitim proizvodnim uvjetima i režimu dušične gnojidbe, 2. genotipizirati odabranu germplazmu pšenice na poznate funkcionalne markere, 3. ponuditi ideotip pšenice kako bi pomogli oplemenjivačima pšenice da odaberu roditelje i optimiziraju svojstva pšenice kroz selekcijski proces ciljajući područje jugoistočne Europe, 4. razviti strategiju prema modelu temeljenom na analizi interakciji genotip*okolina (GEI) koja će povećati učinkovitost programa oplemenjivanja pšenice, i 5. identificirati superiorne genotipove pšenice koji će se koristiti u razvoju mapirajućih  i oplemenjivačkih populacija za buduća istraživanja i oplemenjivački  rad kako bi se osigurala buduća dobit od oplemenjivanja i gospodarska korist za proizvođače pšenice u Hrvatskoj. Nadamo se da će ovaj inovativni i integracijski pristup u istraživanju pšenici rezultirati objavom radova visoke kvalitete, novom nacionalnom istraživačkom platformom za pšenicu i da će povećati konkurentnost i sudjelovanje u od EU financiranim istraživačkim projektima.]]></summary_hr><summary_en><![CDATA[Current and future demands for world wheat production and security require the  exploitation of a suite of novel  approaches to increase both regional and worldwide wheat yields. The most direct and obvious solution to these challenges will be to increase productivity through the adoption of wheat germplasm with improved genetic potential and adaptability to diverse growing conditions. Thus the main objectives of this project proposal include: 1. phenotyping and characterizing elite wheat germplasm from the region for the most important agronomic and quality traits, nitrogen use efficiency (NUE) related traits, and tolerance to main biotic stresses such as Fusarium head blight under different growing conditions and regimes of nitrogen, 2. genotyping selected wheat germplasm using functional markers, 3. identification of wheat ideotypes to help breeders to select parents and optimize wheat traits through selection process targeting South-Eastern European region, 4. development of a modeling strategy for GEI analysis that will help to increase the efficiency of a plant breeding program and 5.  Identification of superior wheat genotypes that will be used to develop mapping and breeding populations for future research and breeding purposes in order to ensure future genetic gains in wheat improvement and economic benefits to farmers community in Croatia.This innovative and integrative approach to wheat research will result in high-quality research papers, a newl national wheat research platform and increased  competitiveness and participation in EU funded research projects.]]></summary_en></project><project>
<id>4027</id><title_hr><![CDATA[Istraživanje granice između neurodegeneracije i neuroregeneracije: identifikacija ključnih molekula pomoću proteomike i funkcionalnih testova na leđnoj moždini sisavaca]]></title_hr><title_en><![CDATA[Exploring the borderland between neurodegeneration and neuroregeneration: identification of key molecules with proteomics and functional assays in the mammalian spinal cord]]></title_en><user_id>5326</user_id><user_firstLast_name>Miranda Mladinić Pejatović</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2016-06</proposal_call><code>IP-2016-06-7060</code><acronim><![CDATA[DefineREgenAgeMode]]></acronim><duration>01.06.2017 - 31.10.2021</duration><status>Završio</status><financ_value>125.821,22 eur</financ_value><scie_area_hr>Prirodne znanosti, Biotehničke znanosti, </scie_area_hr><scie_area_en>Natural sciences, Biotechnical sciences, </scie_area_en><scie_field_hr>Biologija, Biotehnologija, </scie_field_hr><scie_field_en>Biology, Biotechnology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Fakultet biotehnologije i razvoja lijekova]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Biotechnology and Drug Development]]></institution_en><team_members_id>12833, 19202, 19201, 19076, 19202, 25289, </team_members_id><team_members_names><![CDATA[Andrea Nistri, Ivana Tomljanović, Antonela Petrović, Jelena Ban, Ivana Tomljanović, Zrinko Baričević, ]]></team_members_names><keywords_hr><![CDATA[regeneracija sisavaca, Monodelphis domestica, oposum, embrionalni razvoj, središnji živčani sustav, leđna moždina, rast aksona, proteomika]]></keywords_hr><keywords_en><![CDATA[mammalian regeneration, Monodelphis domestica, opossum, embryonal development, central nervous system, spinal cord, axonal growth, proteomics]]></keywords_en><summary_hr><![CDATA[Jedan od glavnih izazova suvremene biologije je nemogućnost odraslog središnjeg živčanog sustava (SŽS) sisavaca da se regenerira i oporavi nakon ozljede. Za razliku od odraslih sisavaca, niži kralježnjaci, kao što su ribe i vodozemci, te viši kralježnjaci tijekom embrionalnog razvoja mogu obnoviti znatan dio svog SŽS. Vrlo je nejasno kako se i zašto regenerativni potencijal gubi tijekom evolucije i razvoja i zašto je vrlo ograničen u odraslih sisavaca. Povoljan model za istraživanje i otkrivanje osnove ovog gubitka je mladi oposum (Monodelphis domestica). Oposumi su tobolčari koji se rađaju vrlo nezreli i imaju jedinstvenu mogućnost uspješne regeneracije leđne moždine nakon ozljede u prva dva tjedna svog života, te stoga pružaju izuzetnu priliku za istraživanje neuronalne regeneracije. U svojim sam prethodnim istraživanima identificirala gene čiji se izražaj razlikuje u tkivu leđne moždine oposuma koji imaju ili nemaju sposobnost regeneracije. U ovom istraživanju želimo nadograditi prijašnji pristup analizom proteoma tkiva leđne moždine oposuma različite dobi, kako bi se otkrile molekule povezane s regenerativnim rastom aksona i proliferacijom matičnih stanica. Inhibicijom aktivnosti odabranih molekula ispitat će se njihova funkcionalna uloga u regeneraciji živčanog tkiva, koristeći in vitro preparate intaktne leđne moždine i napredno mikroskopiranje. Paralelno, pripremiti ćemo i analizirati primarne stanične kulture iz tkiva leđne moždine oposuma različite dobi, kako bi testirali odabrane molekule, s težištem na onima koje kontroliraju aktivnost matičnih stanica vezanu za regeneraciju. Ovo originalno interdisciplinarno temeljno istraživanje koristi jedinstveni životinjski model i ujedinjuje napredne tehnike biotehnologije te molekularne i stanične neurobiologije. Rezultati ovog projekta mogli bi dati značajan doprinos razumijevanju regeneracije živčanog tkiva sisavaca, ali i pružiti osnovu za buduće nove terapijske postupke vezane za neurodegenerativne poremećaje.]]></summary_hr><summary_en><![CDATA[One of the major challenges of modern biology concerns the inability of the adult mammalian central nervous system (CNS) to regenerate and repair itself after injury. Unlike the situation in adult mammals, lower vertebrates, such as fish and amphibians, and embryonal higher vertebrates can regenerate significant portions of their CNS. It is poorly understood why this potential is lost with evolution and development, and becomes very limited in adult mammals. An advantageous model to understand the basis of this loss is the neonatal opossum (Monodelphis domestica). Opossums are marsupials born immature, with the unique ability to successfully regenerate spinal cord after injury postnatally: this property, therefore, offers an exceptional tool to study neuro-regeneration. In my previous studies I have identified the genes differentially expressed in the regenerating and non-regenerating opossum spinal tissue. In the present application we wish to upgrade approach and to analyze the proteoms of the spinal tissue of the opossums at different ages, looking for molecules associated with regenerative axon growth and stem cell proliferation. The activity of candidate molecules will be inhibited to investigate their functional role in neuronal regeneration using the in vitro intact spinal cord preparation and advanced imaging. In parallel, we will prepare and analyze opossum primary spinal cell cultures made from the animals of different age, to test candidate proteins, with focus on those involved in stem/progenitor cell activity related to regeneration. This original interdisciplinary basic research project, unique in the choice of the animal model to be used, combines advanced techniques of biotechnology and molecular and cellular neurobiology. The results of the project would make substantial contribution to our understanding of neuronal regeneration in mammals, and also provide candidate targets for future novel therapeutic interventions for neurodegenerative disorders.]]></summary_en></project><project>
<id>4032</id><title_hr><![CDATA[Tranzicija hrvatskih elita iz Habsburške Monarhije u jugoslavensku državu]]></title_hr><title_en><![CDATA[The Transition of Croatian Elites from the Habsburg Monarchy to the Yugoslav State]]></title_en><user_id>4459</user_id><user_firstLast_name>Iskra Iveljić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2016-06</proposal_call><code>IP-2016-06-5974</code><acronim><![CDATA[Croelite]]></acronim><duration>01.03.2017 - 30.12.2020</duration><status>Završio</status><financ_value>50.273,94 eur</financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Povijest, </scie_field_hr><scie_field_en>History, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Filozofski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Humanities and Social Sciences]]></institution_en><team_members_id>19116, 19067, 19089, 19087, 19326, 19275, 19356, 19406, </team_members_id><team_members_names><![CDATA[Ida Ograjšek Gorenjak, Željko Dugac, Božena Vranješ-Šoljan, Branimir Janković, Miha Preinfalk, Žarko Lazarević, Nikola Tomašegović, Mark Cornwall, ]]></team_members_names><keywords_hr><![CDATA[Croatia, Elites, Transition, Habsburg Monarchy, Yugoslavia]]></keywords_hr><keywords_en><![CDATA[Hrvatska, elite, tranzicija, Habsburška Monarhija, Jugoslavija]]></keywords_en><summary_hr><![CDATA[Cilj projekta je analizirati različite segmente hrvatskih elita tijekom posljednje faze postojanja Habsburške Monarhije te prikazati njihovu tranziciju u jugoslavensku državu, obuhvaćajući period od kasnog 19. stoljeća do 1930-ih. Taj je proces  bio za mnoge pripadnike hrvatskih elita težak jer su njime uvedene velike promjene u političkom, nacionalnom, društvenom, gospodarskom, kulturnom, obrazovnom i vojnom aspektu, da se spomenu samo najvažniji. Opći kontekst tranzicije bio je vrlo složen i zahtjevan, te se odvijao na nekoliko razina – nacionalnoj, jugoslavenskoj i međunarodnoj. Njena posljedica bio je i pomak vanjskopolitičke orijentacije države sa središnje na jugoistočnu Europu, iako su srednjoeuropski utjecaji još uvijek bili prisutni na mnogim poljima. Projektni će tim istraživati plemstvo, privrednu i intelektualnu elitu (sveučilišne profesore, političare, liječnike, odvjetnike), administrativnu elitu i poznate žene obuhvaćajući  njihov javni i profesionalni ali i svakodnevni život, povlačeći usporedbe s drugim elitama, ponajprije onima iz Slovenije.Projekt će komparirati mehanizme regrutacije elite u posljednjoj fazi Habsburške Monarhije i prvoj fazi jugoslavenske države, pokazujući (in)kongruencije između naslijeđenih struktura, utjecaja i načina života s novim političkim realnostima.]]></summary_hr><summary_en><![CDATA[The aim of the project is to analyse various segments of Croatian elites during the last phase of the Habsburg Monarchy and to show their transition into the new Yugoslav state, covering thus the period from the late 19th century until the 1930s. This process was strenuous for many members of Croatian elites, since it brought about major changes in political, national, social, economic, cultural, educational and military aspect, to mention just the most important ones. The general context of the transition was very complex and demanding, and it took place on several levels, the national, the Yugoslav and the international. It also implied a shift from Central European to Southeastern European orientation, yet in many fields Central European influences were still present. The project team will research the nobility, the businessmen, intellectual elite  (university professors, politicians, doctors of medicine, lawyers) administrative elite and renown women, encompassing their public and professional as well as everyday life. Comparisons will be drawn with other elites, especially with the Slovenian elites. The project  should compare the mechanisms of regrutation of elites in the last phase of the Habsburg state and the first phase of the Yugoslav one, showing (in)congruencies between inherited structures, influences and a way of life with new political realities.   ]]></summary_en></project><project>
<id>4038</id><title_hr><![CDATA[Koartikulacija u hrvatskom govoru: instrumentalno istraživanje]]></title_hr><title_en><![CDATA[Coarticulation in Croatian speech: instrumental investigation]]></title_en><user_id>19048</user_id><user_firstLast_name>Marko Liker</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2016-06</proposal_call><code>IP-2016-06-5367</code><acronim><![CDATA[KROKO / CROCO]]></acronim><duration>02.03.2017 - 01.07.2021</duration><status>Završio</status><financ_value>47.090,05 eur</financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Filologija, </scie_field_hr><scie_field_en>Philology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Filozofski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Humanities and Social Sciences]]></institution_en><team_members_id>574, 19504, 2844, 19391, 28775, </team_members_id><team_members_names><![CDATA[Vesna Mildner, Arnalda Dobrić, Ines Carović, Ana Vidović Zorić, Karla Zvonar, ]]></team_members_names><keywords_hr><![CDATA[govor, koartikulacija, instrumentalno istraživanje, elektropalatografija (EPG), ultrazvuk (UTI), tipični govor, atipični govor, hrvatski]]></keywords_hr><keywords_en><![CDATA[speech, coarticulation, instrumental investigation, electropalatography (EPG), ultrasound (UTI), typical speech, atypical speech, Croatian]]></keywords_en><summary_hr><![CDATA[Tijekom govora govorni je trakt pod stalnim utjecajem izgovornih zahtjeva više glasova, zbog čega se pokreti izgovornih organa ponekad preklapaju u vremenu i utječu jedan na drugi. Taj se fenomen naziva koartikulacijom i jedan je od središnjih istraživačkih problema u fonetskim i govornim znanostima. Ovaj je istraživački projekt motiviran upravo relevantnošću problema koartikulacije u aktualnom istraživačkom prostoru te nedostatkom instrumentalnih podataka o koartikulacijskim procesima u hrvatskom govoru.Opći je cilj projekta istražiti koartikulacijske procese u tipičnom (urednom) i atipičnom (oštećenom) govoru hrvatskih ispitanika. Istraživanje tipičnoga govora dat će uvid u koartikulacijski potencijal (odnos koartikulacijskog pritiska i otpora) hrvatskih glasova, a istraživanje atipičnog govora pridonijet će boljem razumijevanju senzomotorike govora i njezinog odnosa s koartikulacijom. U cjelini, rezultati će pridonijeti objašnjenju jezično-specifičnih i jezično-univerzalnih aspekata koartikulacije te razlikovanju njezinih tipičnih od atipičnih karakteristika.Ovaj projekt inovativan je u sljedećem: 1. vrsti govornog materijala (smanjenje utjecaja neprirodnih komunikacijskih uvjeta u dosadašnjem laboratorijskom snimanju govora te približavanje spontanom govoru, što će omogućiti relevantnije rezultate), 2. istraživačkim metodama (primijenit će se više instrumentalnih fizioloških i akustičkih tehnika za snimanje govora) te 3. vrsti ispitanika (prvi puta u Hrvatskoj koartikulacija će se istraživati u tipičnom i atipičnom govoru).Krajnji korisnici rezultata ovih istraživanja su u području govornih tehnologija i sinteze govora (stvaranje umjetnog govora te komunikacija čovjek-stroj), klinički fonetičari i logopedi (uspješno odvajanje tipičnih i atipičnih karakteristika govora te kvantitativan instrumentalni pristup dijagnozi i terapiji govornih poteškoća) te lingvisti i fonetičari (bolje razumijevanje složenog govornog funkcioniranja čovjeka).]]></summary_hr><summary_en><![CDATA[During speech vocal tract is under constant influence of more than one speech segment, which causes speech movements to overlap in time and speech segments to influence one another. This phenomenon is called coarticulation and is one of the central research problems in phonetic and speech sciences. This research project is motivated by the relevance of the problem of coarticulation in the research area and by the relative lack of instrumental data on coarticulation in Croatian.The general aim of the project is to investigate coarticulation in typical and atypical (impaired) Croatian speech. The investigation of typical speech will offer the opportunity to develop coarticulatory potential for Croatian speech sounds (the relation between coarticulatory pressure and resistance), while the investigation of atypical speech will contribute to the understanding of speech  sensomotorics and its relation to coarticulation. Main contributions of the research project are: the understanding of language-specific and language-universal aspects of coarticulation as well as more successful differentiation between coarticulation in typical and atypical speech.This project is innovative for three main reasons: 1. type of speech material (the development of communicative situations for the elicitation of quasi-natural speech in the laboratory, which will contribute to more reliable results), 2. research techniques (several instrumental techniques will be used) and 3. types of speakers (coarticulation in Croatian speech will be investigated in typical and atypical speech for the first time).The end users are expected in the following fields: speech technology and synthesis (the development of artificial speech and human-machine communication), clinical phonetics and speech therapy (successful differentiation between typical and atypical speech as well as quantitative approach to diagnosis and therapy) and linguistics and phonetics (better understanding of human speech).]]></summary_en></project><project>
<id>4041</id><title_hr><![CDATA[Razvoj kapilarne mikroprobe za MeV SIMS s primjenom na analizu bioloških materijala]]></title_hr><title_en><![CDATA[Development of the capillary microprobe for MeV SIMS with application on analysis of biological samples ]]></title_en><user_id>2755</user_id><user_firstLast_name>Ivančica Bogdanović Radović</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2016-06</proposal_call><code>IP-2016-06-1698</code><acronim><![CDATA[BioCapSIMS]]></acronim><duration>15.05.2017 - 14.08.2020</duration><status>Završio</status><financ_value>99.117,39 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, Kemija, Biologija, </scie_field_hr><scie_field_en>Physics, Chemistry, Biology, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>4670, 4629, 24346, 25285, </team_members_id><team_members_names><![CDATA[Zdravko Siketić, Milko Jakšić, Marko Barac, Marko Brajković, ]]></team_members_names><keywords_hr><![CDATA[teški ioni, kapilarna mikroproba, MeV SIMS, biološki uzorci, ispodmikronska rezolucija]]></keywords_hr><keywords_en><![CDATA[heavy ions, capillary microbeam, MeV SIMS, biological samples, sub-micron resolution]]></keywords_en><summary_hr><![CDATA[Određivanje molekularnog sastava na staničnom nivou važno je za razumjevanje biokemijskih procesa unutar stanica a time i za istraživanje nastanka pojedinih bolesti. Jedna od obećavajućih masenih spektrometrija za 2D molekularno mapiranje na staničnom nivou je i MeV SIMS, spektrometrija sekundarnih molekularnih iona pomoću iona MeVskih energija koja je 2013. instalirana na ionskoj mikroprobi akceleratora u Zagrebu. Nedavno je pokazano da je s trenutnim eksperimentalnim postavom moguće postići 2D mapiranje molekula unutar stanice s lateralnom razlučljivošću ispod jednog mikrometra. Ipak, puni potencijal metode moglo bi se ostvariti samo korištenjem najtežih iona (npr I, Au) energija oko 30 MeV-a, što u postojećem MeV SIMS sustavu na ionskoj mikroprobi IRB-a nije moguće zbog ograničenja u potrebnim magnetskim poljima ionsko-optičkih elemenata. Naime od ranije je poznato da prinos sekundarnih molekularnih iona jako ovisi o elektronskoj zaustavnoj moći iona koji se koriste kao pobuda, te je znatno veći ako se koriste teški ioni visokih energija. Visoka vjerojatnost ovih procesa omogućila bi da se umjesto složenog sustava fokusirajućih leća ionski snop kolimira na mikronske dimenzije pomoću staklene kapilare. Nova kapilarna mikroproba za MeV SIMS koja bi u potpunosti bila optimizirana za 2D mapiranje bioloških materijala bi zbog svoje jednostavnosti mogla biti u daleko široj primjeni posebno na akceleratorima koji nemaju složene i skupe sustave za fokusiranje iona. Također, kapilarna mikroproba sa masenim spektrometrom bit će izgrađena na centralnoj eksperimentalnoj liniji 6.0 MV tandem akceleratora IRB-a te bi se tako minimizirale i teškoće zakretanja ionskog snopa u skretnom magnetu. Na taj način dobio bi se uređaj koji bi i po lateralnoj razlučljivosti i po prinosu sekundarnih molekularnih iona bio superioran u odnosu na postojeće slične uređaje za masenu spektrometriju bioloških materijala.]]></summary_hr><summary_en><![CDATA[Determination of the molecular composition at the cellular level is important to understand the biochemical processes within the cells and thus to explore the occurrence of certain diseases. One of the promising mass spectrometry methods for 2D molecular mapping at the cellular level is MeV SIMS, spectrometry of secondary molecular ions using MeV ions that was installed in 2013 at the ion microprobe in Zagreb. Recently we have demonstrated that with the current experimental setup we can achieve 2D imaging of molecular distribution within the cell with the sub-micron later resolution. However, the full potential of the method could only be achieved by using heavier ions such as I or Au with energies up to 30 MeV, which is presently not possible in the current MeV SIMS setup due to the limitations in the required magnetic fields in the ion-optical elements. It is already known that the secondary molecular ion yield strongly depends on the electronic stopping power of the used ions which increases significantly for heavier high energy ions. High probability of these processes allow us that instead of a complex system of focusing lenses ion beam can be collimated to micron dimensions by using glass capillaries. New capillary microprobe for MeV SIMS that would be fully optimised for 2D mapping of biological samples due to its simplicity could be very interesting at accelerators facilities that do not have complex and expensive systems for ion focusing. Also, capillary microprobe mass spectrometer will be mounted in the central experimental line of the 6.0 MV tandem accelerator RBI in order to minimise the difficulties of turning ion beam to the other beam lines. In this way the setup can be obtained with the lateral resolution and secondary ion molecular yields that is superior to the existing similar setups for mass spectrometry of biological materials.]]></summary_en></project><project>
<id>4043</id><title_hr><![CDATA[Ekonomski temelji hrvatske književnosti ]]></title_hr><title_en><![CDATA[Economic Foundations of Croatian Literature]]></title_en><user_id>19057</user_id><user_firstLast_name>Maša Kolanovic</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2016-06</proposal_call><code>IP-2016-06-2613</code><acronim><![CDATA[ETHK/EFCL]]></acronim><duration>01.03.2017 - 29.02.2020</duration><status>Završio</status><financ_value>45.292,99 eur</financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Filologija, Povijest, Znanost o umjetnosti, Etnologija i antropologija, </scie_field_hr><scie_field_en>Philology, History, Arts, Ethnology and anthropology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Filozofski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Humanities and Social Sciences]]></institution_en><team_members_id>17880, 3794, 4485, 19280, 13767, 5027, 19338, 3595, 19133, 19050, 4929, </team_members_id><team_members_names><![CDATA[Krešimir Nemec, JASNA HORVAT, Tatjana  Jukić Gregurić, Maciej Falski, Helena Sablić Tomić, Cvijeta Pavlović, Marijana  Hameršak, Danijela Lugarić Vukas, Ivana Drenjančević, Lana Molvarec, Stipe  Grgas Mufa, ]]></team_members_names><keywords_hr><![CDATA[hrvatska književnost, ekonomija, kultura, ekonomske reprezentacije, ekonomsko polje]]></keywords_hr><keywords_en><![CDATA[Croatian literature, Economy, Culture, Economic representations, Economic field ]]></keywords_en><summary_hr><![CDATA[Projektni prijedlog pod nazivom &#39;&#39;Ekonomski temelji hrvatske književnosti&#39;&#39; ima za cilj stvaranje temeljnih znanja za istraživanje odnosa ekonomije i hrvatske književnosti kroz različita razdoblja hrvatske književne povijesti. Ekonomiju ovdje shvaćamo u širem značenju područja i praksi proizvodnje, potrošnje, distribucije i trgovine iako će samo istraživanje obuhvatiti i odnos hrvatske književnosti i ekonomske znanosti kao njegove integralne sastavnice na metodološkom i tematskom planu. Trenutno stanje u istraživanom području u Hrvatskoj bilježi nepostojanje i nedovoljnu zastupljenost istraživanja ove problematike stoga bi važan doprinos ovog projekta bio sustavno istraživanje odnosa ekonomije i hrvatske književnosti koje bi za rezultat imalo inauguraciju ove problematike u domaćem istraživačkom prostoru, stvaranje temelja za njezino sustavno istraživanje te šire prepoznavanje njezine nacionalne relevantnosti i međunarodne kompetitivnosti. Predloženo istraživanje bi izradilo interdisciplinarni metodološki okvir za pristup navedenoj problematici koji bi na relevantan i svrhovit način povezivao znanja filološke, kulturološke i ekonomske analize s kojim bismo zatim pristupili bogatom hrvatskom književnom arhivu povezanom s ekonomskim temama i procesima kroz tri jasno određena problemska fokusa istraživanja, a to su: 1. Istraživanje ekonomskih reprezentacija u tekstovima hrvatske književnosti, 2. Istraživanje pozicije hrvatske književnosti kao institucije u ekonomskom polju i 3. Istraživanje analogija između diskurzivnosti hrvatske književnosti i ekonomije. Jedinstveni doprinos ovog projekta bi bio: 1)  stvaranje interdisciplinarnog metodološkog okvira i 2) primjena novog metodološkog okvira na bogat književni arhiv što bi za rezultat imalo relevantnu artikulaciju ove problematike u hrvatskom istraživačkom prostoru te stvaranje temelja za njezino istraživanje.]]></summary_hr><summary_en><![CDATA[The project proposal “Economic Foundations of Croatian Literature” has the objective of the development of fundamental knowledge for the research of the relationship between economy and Croatian literature over different periods of Croatian literary history. In this case, the term economy is broadly understood as the field and practice of production, consumption, distribution and merchandise. The research will also include the relationship between Croatian literature and economics, as its constitutive component on a methodological, as well as a thematic level. The current state of research is marked by the absence or marginal interest in the above mentioned issues. Therefore, the important contribution of this project would be the inauguration of this research subject into a national research area, by creating a basis for its systematic research and by broadening its recognition as a nationally relevant and internationally competitive field of research. The proposed project aims to construct an interdisciplinary methodological framework that would link philological, cultural and economic analyses and approaches in a relevant and purposeful way. The plentiful Croatian literary archive of economic phenomena and processes will be accessed within this framework with three clearly defined analytical research focuses which are as follows: 1. Research of economic representations in Croatian literary texts; 2. Research of the position of Croatian literature as an institution in the economic field and 3. Research of analogies between the discourses of Croatian literature and economics. The unique contribution of this project would be 1) the creation of an interdisciplinary methodological framework and 2) implementation of the new methodological framework on the rich literary archive that would result with the created foundations for its research in the Croatian scientific environment.]]></summary_en></project><project>
<id>4045</id><title_hr><![CDATA[Sonoelastografija i magnetska rezonancija u dijagnostici i liječenju karcinoma dojke]]></title_hr><title_en><![CDATA[Sonoelastography and magnetic resonance imaging in diagnosis and treatment of breast cancer]]></title_en><user_id>7350</user_id><user_firstLast_name>Boris Brkljačić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2016-06</proposal_call><code>IP-2016-06-2997</code><acronim><![CDATA[EL-MRI-BREAST]]></acronim><duration>20.03.2017 - 19.03.2022</duration><status>Završio</status><financ_value>132.722,81 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Kliničke medicinske znanosti, </scie_field_hr><scie_field_en>Clinical sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb School of Medicine]]></institution_en><team_members_id>19193, 19192, 19226, 5927, 6702, 19251, 19159, 3973, 28888, 28875, </team_members_id><team_members_names><![CDATA[Renata Huzjan Korunić, Rado Žic, KREŠIMIR MARTIĆ, Tajana Štoos-Veić, Čedna Tomasović-Lončarić, Niko Radovic, Eugen Divjak, Gordana Ivanac, Vanja Posavec, Iva Biondić Špoljar, ]]></team_members_names><keywords_hr><![CDATA[ultrazvuk, sonoelastografija, magnetska rezonancija, karcinom dojke, dijagnostika, liječenje]]></keywords_hr><keywords_en><![CDATA[ultrasound, sonoelastography, magnetic resonance imaging, breast cancer, diagnosis, treatment]]></keywords_en><summary_hr><![CDATA[Kvalitativne i kvantitativne osobine različitih lezija dojke dobivenih oslikavanjem sonoelastografijom i magnetskom rezonancijom (MRI) uz primjenu kontrasta biti će uspoređene s nalazima core-biopsije i finalnim poslijeoperacijskim histopatološkim nalazima. Ciljevi su: (1) ustanoviti shear-wave elastografske (SWE) osobine lezija u dojkama i ispitati razlike među in-situ i invazivnim karcinomima stratificiranim prema histopatološkom stupnju (gradusu) i imunohistokemijskom fenotipu, pokazateljima agresivnosti i prognoze karcinoma. Ultrazvučni uređaj nema ograničenje mjerenja maksimalne elastičnosti od 180 kPa, što omogućuje procjenu stvarnih vrijednosti tvrdoće invazivnih karcinoma; (2) Usporediti SWE parametre s morfološkim svojstvima lezija na MRI, obrascima nakupljanja kontrasta na MRI, nalazima difuzijskog MRI oslikavanja i histopatološkim osobinama karcinoma i drugih lezija dojke; (3) ispitati doprinos SWE kao dopune konvencionalnom, B-mode UZV i kontrastnom UZV pri odabiru lezija za biopsiju i procijeniti može li SWE smanjiti stopu potcjenjivanju (underestimation) lezija u uzorku core-biopsije prilikom biopsija lezija pod ultrazvučnim nadzorom, na način da prikaže najtvrđa područja koja treba bioptirati kod sonomorfološki neodređenih lezija; (4) ispitati utjecaj SWE i MRI nalaza na izbor vrste kirurškog zahvata ili odabir neoadjuvantne kemoterapije, te na praćenje odgovora karcinoma dojke na kemoterapiju; (5) ustanoviti SWE i MRI osobine recidiva karcinoma nakon poštednih operacija i onkoplastičnih rekonstrukcija dojke miokutanim režnjevima, te ustanoviti je li SWE bolje od konvencionalnog ultrazvuka korelira s MRI nalazima i može li tako usmjeriti izvođenje biopsije; (6) ustanoviti SWE osobine lezija tijekom ciljanog („second-look“) ultrazvučnog pregleda nakon pozitvnog nalaza MRI dojke, te procijeniti može li SWE modificirati odluku o izvođenju biopsije i promijeniti područje izvođenja biopsije.]]></summary_hr><summary_en><![CDATA[Qualitative and quantitative sonoelastographic and contrast-enhanced magnetic resonance imaging (MRI) features of breast lesions will be compared to the core-biopsy and final postoperative histopathologic findings. Objectives are: (1) To determine shear-wave elastographic (SWE) features of breast lesions and to investigate the differences in in-situ and invasive cancers stratified by the histopathologic grade and immune-histochemical phenotype, which are biomarkers of aggressiveness and prognosis. Ultrasound scanner will be used without capped upper maximum elasticity value of 180 kPa, allowing realistic evaluation of the stiffness of invasive cancers; (2) To correlate SWE parameters, with MRI morphologic features, MRI enhancement patterns, MRI diffusion weighted findings and histopathologic features of cancers and other breast lesions; (3) To determine the impact of the SWE addition to the gray scale and contrast-ehnanced US on the selection of lesions for biopsy and to evaluate ability of SWE to reduce the rate of underestimation of lesions on core-biopsy specimen obtained by US-guided biopsy, by demonstrating the stiffest area for biopsy in undetermined lesions; (4) To explore the impact of SWE features and MRI features on the choice of operative treatment or neoadjuvant chemotherapy and on the monitoring and prediction of breast cancer response to neoadjuvant chemotherapy and to evaluate if SWE is comparable to MRI in prediction of the cancer response to neoadjuvant chemotherapy; (5) To determine SWE and MRI features of recurrent cancer after breast conserving surgery and breast reconstructions with myocutaneous flaps, to demonstrate if SWE better correlates than gray-scale US to MRI findings of recurrence, and thus can target biopsy; (6) To determine SWE features of lesions examined at “second-look” targeted US after positive MRI findings to evaluate whether the addition of SWE to gray-scale US can modify decision to biopsy and to change the extent of biopsy.]]></summary_en></project><project>
<id>4046</id><title_hr><![CDATA[Uloga proteina Spartan u DNA replikaciji]]></title_hr><title_en><![CDATA[The role of Spartan in DNA replication]]></title_en><user_id>7349</user_id><user_firstLast_name>Ivana Marinović Terzić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2016-06</proposal_call><code>IP-2016-06-3097</code><acronim><![CDATA[SprtnRep]]></acronim><duration>01.09.2017 - 28.02.2022</duration><status>Završio</status><financ_value>132.722,81 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Splitu, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Split School of Medicine]]></institution_en><team_members_id>9932, 5769, 6130, 19252, 25210, 28748, </team_members_id><team_members_names><![CDATA[Kristijan  Ramadan, Janoš  Terzić, Matilda Šprung, Jasminka Omerović, Anja Ančić, Mateo Glumac, ]]></team_members_names><keywords_hr><![CDATA[Spartan, DVC1, DNA replikacija, DNA popravak, metaloproteazna domena, hepatocelularni karcinom ]]></keywords_hr><keywords_en><![CDATA[Spartan, DVC1, DNA replication, DNA repair, metalloprotease domain, hepatocellular carcinoma]]></keywords_en><summary_hr><![CDATA[Stabilnost kromosoma tijekom replikacije i popravka DNA je presudna za sprečavanje patološke transformacije stanica. Nedostatnosti DNA popravka uzrokuju razvojne anomalije, preuranjeno starenje (progeriju) i rak. Većina DNA oštećenja blokira napredovanje replikacijske viljuške, jer DNA polimeraza ne može prepoznati oštećene nukleotide. Na takvim mjestima, ubikvitinacija replikacijskog proteina PCNA, koji kao stezaljka kliže po DNA molekuli, pokreće mehanizam  translezijske DNA sinteze (TLS). Nedavno smo identificirali nasljednu mutaciju gena SPRTN (Spartan) kod tri bolesnika, koji su razvili progeroidni sindrom karakteriziran genomskom nestabilnosti i razvojem hepatocelularnog karcinoma (HCC) u mladosti. Druge grupe su pokazale da ja Spartan važan za aktivaciju TLS (Ghosal et al, 2012; Kim i sur, 2013). Naši rezultati pokazuju da Spartan igra važnu ulogu u normalnoj replikaciji DNA, sprečavajući replikacijski stres i održavajući stabilnosti genoma (Marinović-Terzić et al, 2014). U ovom projektu predlažemo da je Spartan metaloproteaza važna za uklanjanje kovalentno vezanih proteina i DNA, čime se omogućava napredovanje replikacijske viljuške.	Cilj ovog projekta je:1. Definirati funkciju Spartan domena,2. Odredite interakcijska svojstva / partnere proteina Spartan3. Opisati dinamiku procesa popravka DNA oštećenja u stanicama bez proteina SpartanVećina tehnika koje ćemo koristiti u ovom radu su uvriježene u našim laboratorijima: Western blot, IP, GST-pulldown, Imunofluorescentna mikroskopija, RNAi, SILAC bazirana masena spektrometrije i protočna citometrija. Koristit ćemo i jednu novu tehniku - CRISPR / Cas9 ciljano preuređivanje gena. Svi pokusi će se raditi na kulturama stanica. Ovaj projekt ima potencijal za generiranje vrlo zanimljivih rezultata i visoku vjerojatnost publiciranja u vrhunskim znanstvenim časopisima. Rezultati ovog projekta će bolje razjasniti specifičnu ulogu proteina Spartan u DNA replikaciji i održavanju genomske stabilnosti.]]></summary_hr><summary_en><![CDATA[The maintenance of chromosomal stability during DNA replication and repair is crucial for preventing patogenic transformation of a cell. Defects in DNA repair cause developmental abnormalities, premature aging, and cancer. Most types of DNA damage block the progression of replication forks, because DNA polymerases cannot recognize damaged nucleotides. At sites of stalled DNA replication fork, replication sliding clamp protein PCNA becomes ubiquitinated and thus initiates translesion DNA synthesis (TLS). Recently, we have identified germline mutations in SPRTN gene (Spartan) in three patients, who developed progeroid syndrome characterized by genomic instability and early onset hepatocellular carcinoma (HCC). Previously it was proposed that Spartan is important for activation of TLS (Ghosal et al, 2012; Kim et al, 2013). Our results show that Spartan plays an essential role in normal DNA replication by preventing DNA replication-stress and maintaining genome stability (Marinovic-Terzic et al, 2014). Here we propose that Spartan is a metaloprotease important for removal of DNA-protein crosslinks, thus enabling the progression of replication forks. Our goal in this project is to:1. Define the functions of Spartan’s domains, 2. Determine Spartans interacting properties/partners, and 3. Describe the dynamics of a DNA damage repair process in Spartan depleted cells. Most of the techniques we will use in this work are established procedures in our laboratories: Western blot, IP, GST-pull down, immunofluorescent microscopy, RNAi, SILAC based mas spectrometry and flow cytometry. One novel technique will be used as well – CRISPR/Cas9 targeted gene editing. All experiments will be performed using cultured cells. This project proposal has a potential to generate very interesting results with high possibility for publications in top scientific journals. Results of this project will help to better understand the specific role of Spartan in DNA replication and genome stability.]]></summary_en></project><project>
<id>4048</id><title_hr><![CDATA[Između istoka i zapada – dolina rijeke Cetine kao komunikacijska poveznica tijekom prapovijesti i antike]]></title_hr><title_en><![CDATA[Where East Meets West – The Cetina River Valley as an Ancient Pathway of Communication (Cetina Valley Survey)]]></title_en><user_id>19187</user_id><user_firstLast_name>Helena Tomas Bakota</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2016-06</proposal_call><code>IP-2016-06-1478</code><acronim><![CDATA[CeVaS]]></acronim><duration>03.04.2017 - 17.10.2024</duration><status>Završio</status><financ_value>79.633,69 eur</financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Arheologija, Povijest, Etnologija i antropologija, </scie_field_hr><scie_field_en>Archeology, History, Ethnology and anthropology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Filozofski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Humanities and Social Sciences]]></institution_en><team_members_id>13548, 6011, 4028, 19516, 19537, 19547, 19557, 7522, 7551, 13192, 25379, 8198, </team_members_id><team_members_names><![CDATA[Tihomila Težak-Gregl, Kornelija Jurin Starčević, Mirjana Sanader, Matija Dronjić, Eleonora Ballan, Giulia Recchia, Maja Gori, Marina Milićević Bradač, Zrinka Šimić-Kanaet, Danijela Roksandić, Jura Triplat, Marcel Burić, ]]></team_members_names><keywords_hr><![CDATA[dolina rijeke Cetine, komunikacijski putevi, prapovijest, antika, naselja, grobnice, trgovačka razmjena, terenski pregled]]></keywords_hr><keywords_en><![CDATA[Cetina River Valley, communication pathway, prehistory, antiquity, settlement pattern, burials, trade and exchange, survey]]></keywords_en><summary_hr><![CDATA[U rano brončano doba u dolini Cetine razvila se cetinska kultura čije se odlike mogu naći po cijelom jadranskome bazenu, Malti i u Grčkoj. Stoga se s pravom može reći da je cetinska kultura predstavljala najznačajniju epohu prapovijesnoga života u dolini; ona ukazuje da su njeni nosioci mogli ostvariti kontakte s udaljenim krajevima. Rijeka Cetina, koja je u nekim svojim dijelovima plovna, pri tim je putovanjima vjerojatno služila kao važan put. Usprkos tako profitabilnoj komunikaciji koja je dolinu povezivala s Jadranom i vibrantnim Sredozemljem, razdoblja prije i nakon cetinske kulture nisu bila podjednako napredna. Jedan od ciljeva projekta jest ustanoviti koji su faktori utjecali na te varijacije kroz vrijeme. Također se namjeravaju utvrditi stupnjevi važnosti doline kao mjesta obitavališta i komunikacijskih puteva kroz prapovijesna i povijesna razdoblja. Ovi bi se ciljevi ostvarili metodom arheološkog rekognosciranja (terenskog pregleda) ciljano odabranih dijelova cetinske doline. Očekuje se da će otkriveni materijal ukazati na intenzitet naseljavanja doline u pojedinim razdobljima, ali i na intenzitet kontakata s ostalim, pogotovo udaljenijim područjima, pa će nam tako i odgovoriti na pitanja do koje je mjere u određenom razdoblju dolina bila izolirana ili pak otvorena vanjskome svijetu. Usporedbe s recentnijim epohama i događajima mogu ukazati na prednosti koje pruža život u tako plodnome okružju, ali isto tako i na nedostatke uvjetovane činjenicom da je cetinska dolina važna poveznica unutrašnjosti Balkanskoga poluotoka i Jadranskoga mora, pa je tako bila metom brojnih sila i poprištem čestih sukoba i ratova. Činjenica da je rimska legija nekoć bila stacionirana upravo u ovoj dolini (rimski vojni logor kod Trilja) govori nam da su slični problemi i sukobi život u dolini ugrožavali i u davnijoj prošlosti. Podaci prikupljeni predloženim rekognosciranjem zasigurno će pružiti bogatstvo novih arheoloških i povijesnih svjedočanstava o dolini Cetine.]]></summary_hr><summary_en><![CDATA[During the Early Bronze Age a culture developed in the Cetina Valley – the Cetina Culture – whose features over time got distributed in the Adriatic basin, Malta and Greece. That culture was a prehistoric highlight of the valley and demonstrated that its inhabitants were capable of establishing far-reaching contacts; the Cetina river, navigable at some parts, may have in that process served as a crucial communication channel. Despite this beneficial river giving access to the Adriatic sea and the vibrant Mediterranean basin, periods prior or posterior to the Cetina Culture were not equally prominent. The project seeks to explore the factors that may have influenced such a diachronic variation. Also, it aims to establish degrees of general importance of the valley as a place of habitation and communication through prehistoric and historic times. These goals will be achieved by archaeological surveying of the purposefully selected parts of the valley. The material recovered during surveying is expected to give an insight into the level of intensity of habitation of the area through time, as well as the intensity of foreign contacts (i.e. the isolation of the valley versus its receptiveness of the outside world). Comparisons to more recent periods or episodes may highlight the advantages of living in a very fertile environment, but also disadvantages caused by the role of the Cetina Valley as a transit zone from the inner Balkan peninsula to the open sea. As such, the valley has been a stage of numerous conflicts and wars. The fact that a Roman legion was once settled in the Valley (the fort of Tilurium) testifies that conflicts may have disturbed the life in the valley even in a more distant past. In brief, data obtained through a systematic archaeological survey will certainly reveal valuable archaeological and historical testimonies, but will also enhance the awareness of present local communities of the rich past of the valley.]]></summary_en></project><project>
<id>4051</id><title_hr><![CDATA[ &#39;&#39;Hrvatski glazbeni i liturgijski kodeksi srednjega vijeka: Interdisciplinarna obrada“ ]]></title_hr><title_en><![CDATA[&#39;&#39;Croatian musical and liturgical medieval codices: Interdisciplinary research“ ]]></title_en><user_id>11216</user_id><user_firstLast_name>Hana Breko Kustura</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2016-06</proposal_call><code>IP-2016-06-6619</code><acronim><![CDATA[CROMUSCODEX70]]></acronim><duration>01.04.2017 - 31.12.2021</duration><status>Završio</status><financ_value>51.173,93 eur</financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Znanost o umjetnosti, Teologija, Filologija, Povijest umjetnosti, </scie_field_hr><scie_field_en>Arts, Theology, Philology, Art history, </scie_field_en><institution_hr><![CDATA[Hrvatska akademija znanosti i umjetnosti]]></institution_hr><institution_en><![CDATA[Croatian Academy of Sciences and Arts]]></institution_en><team_members_id>7861, 19430, 19071, 5685, </team_members_id><team_members_names><![CDATA[Marijana Horvat, Domagoj Volarević, Katarina Livljanić, Rozana Vojvoda, ]]></team_members_names><keywords_hr><![CDATA[srednjovjekovni rukopisi,glazba, liturgija, iluminacije, hrvatska glazba srednjega vijeka]]></keywords_hr><keywords_en><![CDATA[medieval manuscripts, music, liturgy, illuminations, Croatian music of the Middle Ages]]></keywords_en><summary_hr><![CDATA[Projekt &#39;&#39;Hrvatski glazbeni i liturgijski kodeksi srednjega vijeka: Interdisciplinarna obrada“  se bavi interdisciplinarnom obradom liturgijskih i glazbenih kodeksa hrvatskih zemalja u razdoblju od 11. do 17. stoljeća pohranjenih u stranim i domaćim arhivima. To je premijerni pothvat istodobnog rada muzikologa, filologa, liturgičara i povjesničara umjetnosti specijaliziranih za dokumente srednjovjekovne hrvatske glazbe,  pisane riječi,  liturgije i likovnosti. Cilj je komparativna usporedba znanih hrvatskih izvora sa europskim rukopisma i otkriće njihova stvarnog eklezijastičkog porijekla i identiteta koja do danas u većem broju izvora nije poznat. Većina je izvora pohranjena u crkvenim arhivima Hrvatske, no dvadesetak kodeksa se danas čuvaju u  stranim bibliotekama. Ovi izvori trebaju postati dio komparativnih istraživanja. Glazbeni i liturgijski kodeksi koji datiraju od 11. stoljeća naovamo  predstavljaju najraniji sloj izvora hrvatske pismenosti, liturgije i glazbe, koji tek postupno trebaju ući u europske znanstvene publikacije. Projekt se temelji na suvremenim metodama poredbenog istraživanja, transkripcije i transliteracije izvora, rekonstrukcije glazbe iz neumama notiranih kodeksa, teži aktualnom prikazu novih rezultata europskoj i domaćoj znanstvenoj sredini, kao i diseminaciji istih u vidu znanstvenih radova, notnih izdanja-transkripcija i prezentacije na domaćim i međunarodnim znanstvenim simpozijima i radionicama za studente, te audio i video zapisima.]]></summary_hr><summary_en><![CDATA[Project &#39;&#39;Croatian musical and liturgical medieval codices: interdisciplinary research“  deals with interdisciplinary investigation of the liturgical and musical codices of Croatian lands in the period from 11th to 17th century stored in domestic and foreign archives. This is a premier research done simultaneously by musicologists, philologists, liturgists and art historian specializing in medieval documents of Croatian music, written word, liturgy and the arts. The main goal is the investigation of the origin of the Croatian codices in comparison with similar European ones, and discovery of their real ecclesiastical origin and identity. In most cases the real origin and “destination” where the particular chant manuscript was used is still not known. Most of the sources are kept today in the church archives in  Croatia. However, there are around twenty of them stored in foreign archives and libraries. These sources will be used in the comparative research. Musical and liturgical codices dating from the 11th century onward represent the earliest layer of Croatian literacy, liturgy and music, which only gradually have to enter into the European scientific publications. The project is based on modern methods of comparative research, transcription and transliteration of particular Beneventan and Carolingian sources, reconstruction of music from a neumatic musical  notation to the modern, in order to present the new results to the wider European and national scientific environment. Our goal is a dissemination of the results in the form of scientific papers, sheet music-transcriptions and presentations of the most important discoveries  at national and international scientific symposia and workshops.The other part of the project is the research and preparation of the scientific platform  for the new audio and video recordings of the medieval music repertory from Croatian musical sources up to date completely unknown.]]></summary_en></project><project>
<id>4059</id><title_hr><![CDATA[Određivanje ključnih molekula epitelno-mezenhimalne tranzicije kao mogućih ciljeva za terapiju raka jajnika ]]></title_hr><title_en><![CDATA[Drug-induced epithelial-mesenchymal transition in ovarian cancer therapy]]></title_en><user_id>3713</user_id><user_firstLast_name>Anamaria Brozović</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2016-06</proposal_call><code>IP-2016-06-1036</code><acronim><![CDATA[DEvOuT]]></acronim><duration>10.07.2017 - 09.06.2022</duration><status>Završio</status><financ_value>132.722,81 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>17888, 19663, 19635, 19706, 12695, 5551, 19664, 25301, 25314, 23892, </team_members_id><team_members_names><![CDATA[Sanja Dabelić, Zoran Culig, Darija Stupin Polančec, Martin Puhr, Slavko Orešković, Vladimir Banović, Ivan Babić, Margareta Pernar, Juran Kralj, Marija Milković Periša, ]]></team_members_names><keywords_hr><![CDATA[Epitelno-mezenhimalna tranzicija, otpornost na lijekove, rak jajnika, miRNA-200, karboplatina]]></keywords_hr><keywords_en><![CDATA[epithelial-mesenchymal transition, drug resistance, ovarian cancer, miRNA-200, carboplatin]]></keywords_en><summary_hr><![CDATA[U najvećem broju slučajeva rak jajnika dijagnosticira se u uznapredovalom stadiju zbog čega je kemoterapija neuspješna. Kod bolesnica koje odgovore uspješno na terapiju čak u 70-80% bolest se ponovo javlja unutar godine dana. Prema tome, razvoj otpornosti na terapiju glavna je prepreka njene uspješnosti. Karboplatina (CBP) je jedan od lijekova prve linije terapije. Proces epitelno-mezenhimalna tranzicija (EMT) korelira s napredovanjem bolesti i metastaziranjem te otpornosti na terapiju. Literaturni podaci opisuju promjene različitih proteina i miRNA u tim procesima. Međutim, još uvijek nije poznato koje od tih molekula su uključene u oba procesa. U okviru naših preliminarnih istraživanja razvili smo nekoliko staničnih linija raka jajnika otpornih na CBP koje su prošle proces EMT, te u jednoj od njih identificirali smanjenu ekspresiju svih članova miRNA-200 obitelji za koje se iz literature zna da reguliraju ekspresiju mnogih proteina u stanici. Budući da se proces EMT i razvoj otpornosti događaju istovremeno naša je hipoteza da postoje ključne molekule koje se uključene u oba procesa te da bi se one mogle koristiti kao ciljne molekule za terapiju. Prvi cilj ovog projekta je u in vitro modelima kulture stanica pronaći ključne molekule (proteine na transkripcijskom i translacijskom nivou i miRNA) odgovorne za EMT i razvoj otpornosti na CBP i njihovu međusobnu povezanost. Uključenost svake od pronađenih molekula utvrdit će se odgovarajućim funkcionalnim testovima. Drugi cilj je utvrditi ekspresijski status pronađenih molekula u uzorcima tkiva bolesnica (normalno vs tumorsko) te korelirati pronađene promjene s odgovorom bolesnica na terapiju. Treći cilj je potvrditi važnost otkrivenih molekula u regulaciji EMT i razvoju otpornosti na CBP u modelu organoida. Ukupni cilj projekta je pronaći ključne molekule odgovorne za EMT i otpornost na CBP, te moguće korištenje tih molekula u  liječenju bolesnica oboljelih od raka jajnika.]]></summary_hr><summary_en><![CDATA[Most epithelial ovarian cancer patients are diagnosed with advanced-stage disease and do not respond to chemotherapy. About 70-80% of patients, who respond to the chemotherapy, experience a recurrence of cancer within months to years. Therefore the development of tumor drug resistance is the major problem for a successful therapy. Carboplatin (CBP) is one of the drugs in the first-line therapy. Epithelial-mesenchymal transition (EMT) correlates with cancer progression, metastasis and drug resistance. Literature data have shown changes in expression of different proteins and miRNA in these processes. However, it is still not known which molecules are involved in both of these processes. Our preliminary research resulted in establishment of several CBP resistant ovarian cancer cell lines that underwent EMT. In one of these cell lines we found decreased expression of miRNA-200 members, for which it has been known to regulate many different proteins in the cells. Since EMT and development of drug resistance have been shown to occur in the cell simultaneously, our hypothesis proposes the existence of key molecules involved in both of these processes making them valuable therapy targets. The first goal of this project is to determine key molecules (proteins at transcriptional and translation levels and miRNA) involved in EMT and development of drug resistance and to confirm their role by using functional tests. The second goal is to establish the expression pattern of these molecules in tissue samples from patients with ovarian cancer (normal vs tumor) and to correlate these changes with the patient response to the therapy. The third goal is to confirm the importance of identified molecules in EMT and drug resistance development by using organoids culture. The overall goal of this project is to find key molecules involved in EMT and development of drug resistance and to investigate the possibility of using them as targets for ovarian cancer therapy.]]></summary_en></project><project>
<id>4060</id><title_hr><![CDATA[DNA kao dokaz o distribuciji i vitalnosti ugrožene balkanske divokoze]]></title_hr><title_en><![CDATA[DNA as evidence of distribution and vitality of endangered Balkan chamois]]></title_en><user_id>2954</user_id><user_firstLast_name>Nikica Šprem</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2016-06</proposal_call><code>IP-2016-06-5751</code><acronim><![CDATA[BalkCham]]></acronim><duration>01.03.2017 - 29.02.2020</duration><status>Završio</status><financ_value>96.857,87 eur</financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Poljoprivreda, Biotehnologija, </scie_field_hr><scie_field_en>Agriculture, Biotechnology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Agronomski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Agriculture]]></institution_en><team_members_id>6460, 19944, 19869, 20237, 25111, 25184, 25973, 25076, </team_members_id><team_members_names><![CDATA[Magda Sindičić, Elena Bužan, Toni Safner, Peter Lazar, Sunčica Stipoljev, Laura Iacolina, Toni Tešija, Andrea Rezić, ]]></team_members_names><keywords_hr><![CDATA[R. rupicapra balcanica, SNP, MHC, efektivna veličina populacije, inbreeding, populacijska struktura, Dinarske planine]]></keywords_hr><keywords_en><![CDATA[R. rupicapra balcanica, SNP, MHC, effective population size,  inbreeding, population structure,Dinaric mountains]]></keywords_en><summary_hr><![CDATA[Model vrsta projektnog prijedloga je balkanska divokoza (R. rupicapra balcanica), populacija sjeverozapadnih Dinarida u Hrvatskoj. Kao karizmatični papkar, balkanska divokoza, vodeća je vrsta kod očuvanja planinskog ekosustava Balkanskog poluotoka koji je jedan od 35 svjetski važnih lokaliteta biološke raznolikosti. Zbog mala veličina populacije i niska genetska varijabilnost populacija divokoza u Dinaridima podložna je mnogim čimbenicima. Sa svim dosadašnjim spoznajama, glavni cilj našeg projekta je analizirati genetsku strukturu balkanske divokoze, koristeći neutralni (SNP) biljeg i biljeg pod selekcijom (MHC kompleks) za procjenu statusa zaštite i proučiti mehanizme molekularne adaptaciji lokalne populacije. Nadalje, ekstrakcija DNA iz lubanja divokoza odstrjeljenih prije reintrodukcije i usporedba uspješnih sekvenci sa današnjim iz genske banke, te potencijalno rekonstruirati filogeografiju divokoza s Velebita. Okolišna i staništa analiza u GIS-u  provest će se analizom prisutnosti i godišnje migracije životinja. Sve to će se postići interdisciplinarnim istraživačkim timom sastavljenim od agronoma, biologa, šumara i veterinara. Rezultati našeg projekta će pružiti uvid u distribuciju i vitalnost, što je važno u uspostavljanju učinkovitog upravljanja buduće populacije divokoza u Dinaridima. Isto tako moramo biti svjesni da je biološka raznolikost kulturna baština stoga nam je dužnost zaštititi balkansku divokozu za buduće generacije.]]></summary_hr><summary_en><![CDATA[The model species of the project proposal is Balkan chamois (R. rupicapra balcanica), specifically population of the northwestern Dinaric Mountains in Croatia. As a charismatic ungulate, Balkan chamois, is an excellent flagship species for the conservation of the montane ecosystems of the Balkan Peninsula which is one of the world’s 35 biodiversity hotspots. The small population size and low genetic variability of the chamois populations in the Dinaric Mountains make them vulnerable to many factors. With all previous findings considered, main goal of our project is to analyse genetic structure of Balkan chamois, using neutral (SNP) and loci under selection (MHC complex) to estimate conservation status and to study mechanisms of molecular adaptation of local populations. Furthermore, DNA extraction from hunted chamois before reintroduction and comparison of successful sequences with contemporary ones from Gen bank, and potential reconstruction of phylogeography of chamois from Velebit Mountain. An environmental and habitat analyses in GIS will carry out to analysis of habitat occupation and annual migration of animals. This will be achieved by interdisciplinary research team composed of agronomist, biologists, forester and veterinarians. Results of our project will provide insights of distribution and vitality, what is important in establishment of the effective future management of chamois population in Dinaric Mountains. Also we must be aware that biodiversity is a cultural heritage and it is important to protect Balkan chamois for future generations.]]></summary_en></project><project>
<id>4061</id><title_hr><![CDATA[Proizvodnja željeza uz rijeku Dravu u antici i srednjem vijeku: stvaranje i transfer znanja, tehnologija i roba]]></title_hr><title_en><![CDATA[Iron production along the Drava River in the Roman period and the Middle Ages: Creation and transfer of knowledge, technologies and goods]]></title_en><user_id>7810</user_id><user_firstLast_name>Tajana Sekelj Ivančan</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2016-06</proposal_call><code>IP-2016-06-5047</code><acronim><![CDATA[TransFER]]></acronim><duration>01.03.2017 - 30.09.2021</duration><status>Završio</status><financ_value>79.633,69 eur</financ_value><scie_area_hr>Humanističke znanosti, Prirodne znanosti, Tehničke znanosti, </scie_area_hr><scie_area_en>Humanities, Natural sciences, Technological sciences, </scie_area_en><scie_field_hr>Arheologija, Geofizika, Metalurgija, Geografija, </scie_field_hr><scie_field_en>Archeology, Geophysics, Metallurgy, Geography, </scie_field_en><institution_hr><![CDATA[Institut za arheologiju]]></institution_hr><institution_en><![CDATA[Institute of Archaeology in Zagreb]]></institution_en><team_members_id>11254, 11265, 19573, 2885, 3030, 12322, 3259, 12371, 12380, 11263, 12457, 6516, 20538, 25295, </team_members_id><team_members_names><![CDATA[Tatjana Tkalčec, Siniša Krznar, Aleksandra Bugar, Sibila Borojević Šoštarić, Stanko Ružičić, Ivan Marija Hrovatin, Ladislav Lazić, Robert Čimin, Ivan Valent, Branko Mušič, Metka Culiberg, Katarina Botić, Tomislav Brenko, Tena Karavidović, ]]></team_members_names><keywords_hr><![CDATA[Proizvodnja željeza, talioničke peći, sirovina, drveni ugljen, Podravlje, socio-kulturološki odnosi ]]></keywords_hr><keywords_en><![CDATA[Production of Iron, Smelting furnaces, Raw Materials, Charcoal, Drava River Valley, Socio-Cultural Relations]]></keywords_en><summary_hr><![CDATA[Cilj projekta je proširiti spoznaje o primarnoj obradi željeza u nizinskom području rijeke Drave te definirati značenje proizvodnje željeza u kontekstu socio-kulturoloških odnosa u različitim povijesnim razdobljima (antika i srednji vijek). Projektni zadaci usmjereni su na važna pitanja: 1. definirati podrijetlo željezne rude i potrebnih resursa (glina, voda, drvo); 2. definirati tehnologiju obrade željezne rude kroz povijesna razdoblja;3. definirati utjecaj proizvodnje željeza u kontekstu socio-kuturoloških odnosa. Važan naglasak u svim fazama projekta stavljen je na interdisciplinarna istraživanja. Provest će se preliminarna istraživanja nizinskog prostora uz rijeku Dravu primjenjujući arheološke, geološke i geofizičke metode. Na temelju dobivenih rezultata poduzet će se uzorkovanje tla radi definiranja izvora sirovine, kao i ciljana arheološka istraživanja na dvije odabrane pozicije. Fokus istraživanja usmjerit će se prema promjenama u tehnologiji obrade željeza kroz primjenu različitih tipova peći u različitim razdobljima. Na uzorcima će se provest arheometalurške i metalografske analize s ciljem dobivanja podataka o tehnologiji prerade rude u određenom razdoblju, ali i njena podrijetla, odnosno veze s geološkom podlogom. Analizom vrste drva, posredno će se dobiti slika krajolika (šume) dravske nizine. Očekuje se da će projekt pružiti nove podatke za razumijevanje promjena u tehnologiji obrade željezne rude koje su se dogodile, primarno, unutar istog prostora kroz vrijeme.Sinergijski efekt interdisciplinarnog istraživačkog tima i sveobuhvatna metodologija omogućit će, kroz praćenje gotovih željeznih proizvoda u svakodnevnici, razumijevanje socioloških i kulturoloških odnosa u nizinskom dravskom prostoru, ali i u širem, srednjeeuropskom kontekstu.Novi podaci bit će prikazani pomoću GIS platforme te time u odgovarajućoj formi javno dostupni za razmatranja prostornih korelacija unutar samih metalurških kompleksa, ali i u odnosu na šire područje.]]></summary_hr><summary_en><![CDATA[The aim of the project is to expand knowledge about the primary processing of iron in the lowland area of the Drava River and to define the significance of iron production in the context of socio-cultural relations in the context of ancient and medieval societies. The project focuses on several important aspects: 1. To define the source of iron ore and necessary resources (clay, water, wood); 2. To define the technology of processing iron ore throughout historical periods; 3. To define the impact of iron production in the context of sociocultural relations. An important emphasis is placed on interdisciplinary research in all phases of the project. Preliminary investigation of the lowlands will be performed using archaeological, geological, and geophysical methods. Soil sampling will take place on the basis of obtained results, as will targeted archaeological excavation at two selected sites. Research will be focused on changes in the technology of iron processing through the used of various kinds of furnaces in different periods. Archaeometallic and metallurgical analyses will be performed on samples to obtain data about the processing of ore in a given period, but also its origin in terms of the geology. Through charcoal analysis, the wood types will indirectly offer information about the then landscape (forests). The project is expected to offer new data for understanding changes in the technology of processing iron ore that occurred within the same area throughout time. The synergistic effect of the interdisciplinary research and the comprehensive methodology will enable, through analysis of the finished everyday iron products, comprehension of social and cultural relations in the lowland Drava valley, but also in a wider, central European context. New data will be presented in a GIS platform, enabling public access to consideration of spatial correlations within the metallurgical complex, but also referring to the broader region.]]></summary_en></project><project>
<id>4064</id><title_hr><![CDATA[Rekonstrukcija prapovijesnog (od neolitika do brončanog doba) načina života na području Hrvatske – multidisciplinarni pristup ]]></title_hr><title_en><![CDATA[Reconstructing prehistoric (Neolithic to Bronze Age) lifestyles on the territory of Croatia – a multidisciplinary approach ]]></title_en><user_id>2670</user_id><user_firstLast_name>Mario Novak</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2016-06</proposal_call><code>IP-2016-06-1450</code><acronim><![CDATA[PASTLIVES]]></acronim><duration>01.04.2017 - 31.03.2021</duration><status>Završio</status><financ_value>78.631,63 eur</financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Arheologija, </scie_field_hr><scie_field_en>Archeology, </scie_field_en><institution_hr><![CDATA[Institut za antropologiju]]></institution_hr><institution_en><![CDATA[Institute for Anthropological Research]]></institution_en><team_members_id>19178, 19197, 19174, 19212, 19232, 19225, 1439, 2764, 24314, </team_members_id><team_members_names><![CDATA[Stefano Benazzi, Jacqueline Balen, Tamás Hajdu, Claudio Tuniz, Ron Pinhasi, Sarah McClure, Mislav Čavka, Ivor Janković, Mario Carić, ]]></team_members_names><keywords_hr><![CDATA[prapovijest, Hrvatska, način života, bioarheologija, populacijska struktura, mobilnost, prehrana, nasilje]]></keywords_hr><keywords_en><![CDATA[prehistory, Croatia, lifestyle, bioarchaeology, population structure, mobility, diet, violence]]></keywords_en><summary_hr><![CDATA[Svrha ovog projekta jest istražiti kompleksan set bioloških, društvenih i kulturnih promjena i procesa koji su se odvijali na području Hrvatske između ranog neolitika i kasnog brončanog doba (6000.-1000. god. pr. Kr.) kroz sveoubuhvatno multi- i interdisciplinarno istraživanje ljudskih bioloških ostataka koje kombinira klasične arheološke i bioarheološke metode s najsuvremenijim tehnikama kao što su analize stabilnih izotopa i drevne DNA, radiološke i geometrijsko-morfometrijske analize, radiokarbonsko datiranje i mikroCT skeniranje. Istraživanjem će biti obuhvaćeno 20 prapovijesnih arheoloških nalazišta iz svih krajeva Hrvatske s 400 kostura (300 kosturnih i 100 paljevinskih ukopa). PASTLIVES projekt će obraditi slijedeća istraživačka pitanja: a) populacijska kretanja, demografija i društvena organizacija; b) populacijska genetika; c) prehrana i opće zdravlje; d) namjerno nasilje i sukobi. Spomenuta pitanja biti će proučavana kroz korištenje dva glavna pristupa: a) regionalni, i b) temporalni, tj. projekt će uvidjeti postoje li regionalne i kronološke razlike u određenim biološkim pokazateljima kao što su prosječna životna dob, očekivani životni vijek, prehrana i opće zdravstveno stanje između proučavanih prapovijesnih populacija. Uz to, dobiveni podaci usporedit će se na temelju spola te dobnih i socijalnih skupina kako bi se provjerilo je li neka od ispitivanih kategorija bitno utjecala na kvalitetu života analiziranih osoba. Kako bi se dobio još bolji uvid u istraživane fenomene rezultati dobiveni ovim istraživanjima usporedit će se sa sličnim podacima iz Mađarske. Predloženi pristup će omogućiti bolje razumijevanje i dobivanje jasnije slike o različitim aspektima prapovijesnog života (i smrti) kao što su populacijska struktura, pogrebne prakse i običaji, pojava nasilja,  prehrana, mobilnost i seobe na području Hrvatske ali i u širem europskom kontekstu. ]]></summary_hr><summary_en><![CDATA[This project will investigate a complex set of biological, social and cultural changes and processes that took place on the territory of the present-day Croatia between the early Neolithic and the late Bronze Age (ca 6000 BCE and 1000 BCE) through a comprehensive multi- and interdisciplinary study of human biological remains using a combination of conventional archaeological and bioarchaeological methods, stable isotopes, radiological and aDNA analyses, radiocarbon dating, microCT scanning, and geometric morphometric analyses. The project will involve 20 Croatian prehistoric sites with over 400 individuals (300 inhumation and 100 cremation burials). PASTLIVES project will address the following research questions: a) population movements, demography and social organization; b) population genetics; c) subsistence and overall health; and d) violence and conflict. These objectives and research questions will be explored by using two main approaches: regional (cross-sectional) and temporal (longitudinal), i.e. the project will establish possible regional and temporal differences between the prehistoric populations in terms of studied parameters such as average age at death, life expectancy, diet, and general health. All observed data will be compared in terms of sex, age and social groups in order to test whether any of these features played a significant role in the quality of life of the analyzed individuals. In order to get a better perspective the data obtained by this study will be compared with contemporaneous bioarchaeological, isotopic and genetic data from Hungary. This approach will enable a better understanding of various aspects of prehistoric life (and death) such as population structure, mortuary practices, violence, diet and mobility on the territory of the present-day Croatia but also in a broader European context.]]></summary_en></project><project>
<id>4065</id><title_hr><![CDATA[Razlaganje električnim poljem u tankim optičkim slojevima - nanostrukturiranje, dopiranje, porozni slojevi]]></title_hr><title_en><![CDATA[Electric field assisted dissolution in thin optical films - nanostructuring, doping, porous layers]]></title_en><user_id>1019</user_id><user_firstLast_name>Vesna Janicki</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2016-06</proposal_call><code>IP-2016-06-2168</code><acronim><![CDATA[REPTOSNANODOPS]]></acronim><duration>01.09.2017 - 28.02.2022</duration><status>Završio</status><financ_value>124.693,08 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, </scie_field_hr><scie_field_en>Physics, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>812, 2656, 2846, 19499, 2916, 25344, 28902, 20097, 25531, 25533, </team_members_id><team_members_names><![CDATA[Jordi Sancho-Parramon, Boris Okorn, Jordi Arbiol, Miodrag Oljaca, Vesna Blažek Bregović, Petar Pervan, TamilSelvi Selvam, Ivana Fabijanić, Du Pasquier Aurelien, Persefoni Kechagia, ]]></team_members_names><keywords_hr><![CDATA[tanki slojevi, dopiranje, razlaganje električnim poljem, Li-ion tankoslojne baterije, porozni slojevi, metalne nanočestice, nanostrukturiranje]]></keywords_hr><keywords_en><![CDATA[thin films, doping, electric field assisted dissolution, Li-ion thin film batteries,  porous layers,  metal nanoparticles, nanostructuring]]></keywords_en><summary_hr><![CDATA[Proces izmjene metalnih iona se koristi već stotinama godina u proizvodnji obojenih stakala. Kao izvor metalnih iona može se koristiti sloj metala u čvrstom stanju. Da bi se ubrzala difuzija primjenjuje se umjereno zagrijavanje i električno polje. Istraživanja su pokazala da u ovakvim uvjetima dolazi do razlaganja metalnih nanočestica (NČ) uronjenih u staklo, dielektrični tanki sloj ili višeslojni sustav. Ovaj proces je poznat kao razlaganje električnim poljem (EFAD - electric field assisted dissolution). Ovaj proces ima nekoliko zanimljivih efekata. Primjenom EFAD-a na NČ uronjene u dielektričnu matricu, u njoj ostaju šupljine - pore. Razlaganjem metalnih NČ primjenom strukturirane elektrode, uzorak s elektrode se preslikava na sistem s metalnim NČ. Zagrijavanjem podloge dopirane metalnim ionima u njoj se formiraju NČ. Nedavno je pokazano da metal ponovno izlazi na površinu zagrijavanjem u atmosferi vodika, formirajući inverzni uzorak onome strukturirane primijenjene elektrode. Navedeno pokazuje brojne mogućnosti EFAD-a: dopiranje, formiranje poroznih slojeva i restrukturiranje. No, unatoč velikom potencijalu EFAD-a, znanstvene aktivnosti koje ga uključuju nisu brojne, te ostaju na nivou baznih istraživanja, s primjenom samo za pripremu nanokompozitnog stakla s Ag NČ. Ovim projektom bi se sistematično istražio EFAD kao metoda dopiranja i izrade poroznih slojeva. Projekt se ne bi ograničio samo na bazna istraživanja. Postignute spoznaje bi se primijenile za poboljšanje karakteristika punjivih litijskih tankoslojnih baterija i izradu nanostruktura reverznim restrukturiranjem. Radi znatnog potencijala EFAD-a, dio vremena i resursa će se posvetiti i ostalim mogućim primjenama.]]></summary_hr><summary_en><![CDATA[The ion exchange process has been used for hundreds of years in production of stained glass windows. A solid metal film can be used as the dopant source. Moderate annealing and electric field are applied to enhance the penetration of dopant ions. Recent research has shown that these conditions enable the dissolution of metal nanoparticles (NP), whether they are embedded in glass, dielectric thin film or multilayer system. This process in known as electric field assisted dissolution (EFAD). It opens many different possibilities. EFAD applied to NP embedded in dielectric matrix results in pores remaining on the positions of NP. If structured electrode is applied to NP containing system, the pattern from the electrode is copied onto the system. By annealing a metal ion doped substrate, metal NP form in the substrate. Very recent research has shown that annealing in hydrogen atmosphere makes metal ions diffuse to the surface, forming pattern inverse to the one of the applied electrode. All of this presents numerous possibilities of EFAD: doping, porous layers formation and restructuring. However, despite of EFAD great potential, scientific activities involving this process remain modest, at the level of a fundamental research and applied only for Ag NP nanocomposite glass preparation. This project will systematically study EFAD as a method for doping of different kinds of substrates and for preparation of porous layers. The project will not be limited merely to fundamental research. The obtained results will be applied to improve characteristics of rechargeable thin film lithium batteries and fabrication of nanostructures by reverse restructuring. Due to the significant potential of EFAD, part of time and resources will be devoted to the other applications as well. ]]></summary_en></project><project>
<id>4071</id><title_hr><![CDATA[Naracije straha: Od starih zapisa do nove usmenosti]]></title_hr><title_en><![CDATA[Narrating Fear: From Archival Records to a New Orality]]></title_en><user_id>7999</user_id><user_firstLast_name>Renata Jambrešić Kirin</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2016-06</proposal_call><code>IP-2016-06-2463</code><acronim><![CDATA[FEAR]]></acronim><duration>17.03.2017 - 16.09.2021</duration><status>Završio</status><financ_value>75.377,26 eur</financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Etnologija i antropologija, </scie_field_hr><scie_field_en>Ethnology and anthropology, </scie_field_en><institution_hr><![CDATA[Institut za etnologiju i folkloristiku]]></institution_hr><institution_en><![CDATA[Institute of Ethnology and Folklore Research in Zagreb]]></institution_en><team_members_id>19149, 19642, 19157, 19147, 608, 19697, 19264, </team_members_id><team_members_names><![CDATA[Jelena Marković, Evelina  Rudan Kapec , Luka  Šešo, Nataša Polgar, Una  Bauer, Natka Badurina, Suzana Marjanić, ]]></team_members_names><keywords_hr><![CDATA[folkloristika, naracija, strah, performativnost, usmenost, usmena tradicija, sekundarna usmenost, nova usmenost, digitalni folklor]]></keywords_hr><keywords_en><![CDATA[folklore research, narration, fear, performativity, orality, oral tradition, secondary orality, new orality, weblore]]></keywords_en><summary_hr><![CDATA[Cilj projekta Naracije straha: od starih zapisa do nove usmenosti (FEAR) jest istražiti kako se pripovjednim strategijama i propovijed(a)nim događajima strahovi oblikuju, potiču, usmjeruju i rastaču u svakodnevnoj izravnoj komunikaciji, ali i u javnome diskursu, u medijima i na društvenim mrežama, u književnosti, vizualnim i izvedbenim umjetnostima i dr. Nadovezujući se na tradiciju istraživanja koja su Institut za etnologiju i folkloristiku upisala na kartu svjetske folkloristike, istraživački tim na projektu Naracije straha kani objediniti recentne spoznaje folklorističkih, književnoteorijskih, kulturnoantropoloških, feminističkih, psihoanalitičkih i drugih pristupa strahu u narativnim tekstovima različite provenijencije: usmeni, pisani, stari folkloristički zapisi, noviji etnografski zapisi, sudski zapisnici, logoraška svjedočenja, naracije mrežno oblikovanih “zajednica sjećanja” i “paranoičnih skupina”. Cilj projekta je pokazati prožimanje kodova pisane i usmene, medijske i mrežne „narativne kulture“, izdvojiti elemente pripovjedne artikulacije i autorefleksije govornika obuzetog strahom, kao i uočiti snagu magijskog potencijala jezika da govornika suoči sa strahom (tzv. ritualno „istjerivanje straha“), ali i terapeutskog potencijala priče (npr. narativna terapija, priče o traumi). Brojnim terenskim istraživanjima, interaktivnim mrežnim Arhivom straha i teorijskim promišljanjima fenomena koji se – uz nadu i poniženje - smatra ključnim za razumijevanje novih geopolitičkih i kulturnih podjela zemalja svijeta, suradnici na projektu će pridonijeti boljem poznavanju političkog i afektivnog, grupnog i individualnog, društvenog i virtualnog ponašanja ljudi u čijem su temelju (mahom nesvjesni) strahovi, porivi i vjerovanja. Namjera mu je afirmirati folkloristiku kao humanistički utemeljenu, inovativnu i refleksivnu disciplinu koja svaki fenomen verbalnog folklora promatra u njegovoj cjelini – od individualne varijacije do kulturne specifičnosti.]]></summary_hr><summary_en><![CDATA[The aim of the project Narrating Fear: From Archival Records to a New Orality (FEAR) is to research the ways in which narrative strategies and narrated/narrative events help to shape, instill, direct and resolve fears in everyday direct communication, but also in public discourse, on social networks,  media, literature, visual and performing arts, and others. Continuing the tradition of research that has put the IEF on the map of world folkloristics, FEAR’s research team intends to bring together the recent knowledge of folklore research, literary theory, cultural anthropology, feminism, psychoanalysis, and other approaches to fear in narrative texts of various provenances: oral, written, old folkloristic and newer ethnographic writings, court records, camp witness testimonies, and narrations of the network of “community of memories” and “paranoid groups”. The project aims to show the interpenetration of the codes of written and oral, medial and network “narrative culture”, to outline the elements of narrative articulation and self-reflexion of fear-stricken speaker, as well as noting the power of language’s magical potential to make the speaker face their fear (so-called ritualistic “fear exorcising”), but also the story’s therapeutic potential (e.g. narrative therapy). Through numerous field researches, interactive Fear Archive and theoretical reflections of the phenomenon that is – along with hope and humility – considered crucial to understanding the new geopolitical and cultural divisions of countries, our collaborators will contribute to a better cognition of the political and affective, group and individual, social and virtual human behavior, which serves as basis for fears, drives and beliefs. The intention of FEAR is to affirm folkloristics as an innovative, reflexive, and humanistic discipline, which observes every phenomenon of verbal folklore as a whole – from individual variation to cultural specificity.]]></summary_en></project><project>
<id>4072</id><title_hr><![CDATA[Antun Jančić i fortifikacijska arhitektura Mletačke Republike]]></title_hr><title_en><![CDATA[Antun Jančić and Fortification Architecture of the Venetian Republic]]></title_en><user_id>2693</user_id><user_firstLast_name>Andrej Žmegač</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2016-06</proposal_call><code>IP-2016-06-5776</code><acronim><![CDATA[JANCIC]]></acronim><duration>01.03.2017 - 29.02.2020</duration><status>Završio</status><financ_value>24.075,92 eur</financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Povijest umjetnosti, Povijest, </scie_field_hr><scie_field_en>Art history, History, </scie_field_en><institution_hr><![CDATA[Institut za povijest umjetnosti]]></institution_hr><institution_en><![CDATA[Institute of Art History, Zagreb]]></institution_en><team_members_id>17219, 1397, </team_members_id><team_members_names><![CDATA[Elisabetta Molteni, Darka Bilić, ]]></team_members_names><keywords_hr><![CDATA[utvrde, arhitektura, Antun Jančić, Mletačka Republika, Dalmacija, Johann Matthias von der Schulenburg]]></keywords_hr><keywords_en><![CDATA[fortifications, architecture, Antun Jančić, Venetian Republic, Dalmatia, Johann Matthias von der Schulenburg]]></keywords_en><summary_hr><![CDATA[U središtu projekta stoji djelo Antuna Jančića, po svemu sudeći važnoga vojnog arhitekta Mletačke Republike. Prvi je cilj projekta utvrditi glavne biografske činjenice, lokacije i opseg njegovih aktivnosti te procijeniti njegovo djelo. Hipoteza je projekta da je Jančić bio najvažniji graditelj utvrda s hrvatske strane Jadrana. Metodološki, tumačit će ga se u kontekstu ostalih mletačkih graditelja te institucija i procedura pri gradnji utvrda. Živio je u kasno doba Mletačke Republike te će ovaj projekt preko teme Jančića svjesno afirmirati pojam „kasnih mletačkih utvrda“. Rezultati projekta bit će izlaganja na konferencijama, znanstveni radovi te međunarodni skup u Hrvatskoj o kasnim mletačkim utvrdama. Ne manje važna bit će usporedna popularizacija teme.]]></summary_hr><summary_en><![CDATA[The focus of the project is the work of Antun Jančić, apparently an important military architect of the Venetian Republic. The first objective of the project is to identify the main biographical facts, the locations and the scope of his activities and to evaluate his work. The hypothesis of the project is that Jančić was the most important fortification architect coming from the eastern side of the Adriatic. As the methodology is concerned, he will be interpreted in the context of other Venetian architects, institutions and procedures in the construction of fortifications. He has lived in the late period of the Venetian Republic, so this project will through the topic of Jančić consciously be devoted to the concept of &#39;&#39;late Venetian fortresses&#39;&#39;. Results of the project will be participating at conferences, an international conference in Croatia on late Venetian fortifications and research papers. No less important will be a parallel popularization of the subject.]]></summary_en></project><project>
<id>4073</id><title_hr><![CDATA[Glazbeni izvori Dalmacije u kontekstu srednjoeuropske i mediteranske glazbene kulture od 18. do 20. stoljeća]]></title_hr><title_en><![CDATA[Musical sources of Dalmatia in the context of the Central European and Mediterranean musical culture from the 18th to the 20th century]]></title_en><user_id>11264</user_id><user_firstLast_name>Ivana Tomić Ferić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2016-06</proposal_call><code>IP-2016-06-2061</code><acronim><![CDATA[GIDAL]]></acronim><duration>01.03.2017 - 28.02.2021</duration><status>Završio</status><financ_value>75.173,00 eur</financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Znanost o umjetnosti, Povijest, Etnologija i antropologija, </scie_field_hr><scie_field_en>Arts, History, Ethnology and anthropology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Splitu]]></institution_hr><institution_en><![CDATA[University of Split]]></institution_en><team_members_id>17763, 19257, 19759, 19208, 24402, </team_members_id><team_members_names><![CDATA[Maja Milošević, katica burić ćenan, Vilena Vrbanić, Jelica  Valjalo Kaporelo , Paula Jurišić, ]]></team_members_names><keywords_hr><![CDATA[glazbeni arhivi, glazbene zbirke, muzikalije, glazbeni život, glazbena baština, Split, Hvar, Zadar, Dubrovnik, Hrvatska, Europa]]></keywords_hr><keywords_en><![CDATA[music archives, music collections, music manuscripts and prints, musical life, musical heritage, Split, Hvar, Zadar, Dubrovnik, Croatia, Europa]]></keywords_en><summary_hr><![CDATA[Slojevitost glazbene kulture šireg dalmatinskoga područja odraz je višestoljetno njegovanog i širokim utjecajima prožetog pučkog, crkvenog i umjetničkog muziciranja. Kako bi se ta slojevitost jasno identificirala, potrebno je  prikupiti i interpretirati materijalnu glazbenu baštinu, pohranjenu u crkvenim, samostanskim, privatnim ili pak arhivima kulturnih institucija diljem obale. U početnim se fazama projekta predviđa rad na sređivanju, digitalizaciji i katalogizaciji glazbenih zbirki (u Splitu, Hvaru, Zadru, Dubrovniku), a potom na njihovoj analizi, kontekstualizaciji i interpretaciji kako bi se omogućila (re)konstrukcija (povijesti) glazbene kulture i određivanje njezine uloge u stvaranju lokalnog, regionalnog, nacionalnog i transnacionalnog kulturnog identiteta. Ciljevi projekta: obrada (transkripcija, prijevod) korespondencije J. Bajamontija; tiskano izdanje tematskog kataloga djela J. Raffaellija; digitalizacija rukopisnih muzikalija A. Novaka; kataloška obrada  zbirke muzikalija u Arhivu Dominikanskoga samostana u Starome Gradu; rekonstrukcija djelovanja i repertoara zadarskog opernog kazališta (Teatro Verdi); analiza opusa manje poznatih domaćih i stranih glazbenika koji su djelovali u Dubrovniku od 18. do 20. stoljeća (T. Resti, G. Valenti, A. Frezza, G. Kraglich, G. Zabolio); kontekstualizacija glazbenog života Dalmacije u okvirima odgovarajućih europskih strujanja.Važnost predloženog projekta ogleda se u otkriću novih spoznaja o hrvatskoj glazbenoj baštini ali i onoj europskoj sačuvanoj u Hrvatskoj, koje će poslužiti kao čvrsta referenca praktičnim glazbenicima i budućim istraživačima povijesti umjetničke (crkvene i svjetovne) glazbe. Tijek ostvarenih rezultata bit će popraćen objavom niza članka, većih studija i monografija te uključivanjem dobivenih podataka u međunarodne banke podataka i u domaći i inozemni izvoditeljski repertoar pojedinih dosada nepoznatih i nedostupnih vrijednih djela hrvatskih autora 18., 19. i 20 stoljeća.]]></summary_hr><summary_en><![CDATA[The multi-layered musical culture of the wider Dalmatian area is the reflection of the folk, sacred and artistic music making inherited for the centuries. In order to clearly identify these layers it is necessary to collect and to interpret the material musical heritage, stored in churches, monasteries, private archives and cultural institutions along the Adriatic coast. The work on arranging, digitalisation and cataloguing of music collections (at Split, Hvar, Zadar, Dubrovnik) is predicted for the initial stages of the project, followed by their analysis, contextualization and interpretation to allow (re)construction of the history of musical culture and determination of its role in the creation of local, regional, national and trans-national cultural identity.Scientific objectives of the project: elaboration of the correspondence of  J. Bajamonti;  thematic catalogue of works of J. Raffaelli; digitalisation of music manuscripts of A. Novak; cataloguing of music manuscripts and prints from the Archives of the Dominican monastery at Stari Grad; reconstruction of the activities and repertoire of the Zadar opera theatre (Teatro Verdi); work analysis of less known domestic and foreign musicians in Dubrovnik from 18th to the 20th century; contextualization of the Dalmatia musical life in the frame of the relevant European currents. Proposed project importance reveals through the discovery of new facts about not only Croatian musical heritage but also the European one preserved in Croatia, facts which will serve as a strong reference to practical musicians and all future researchers of the history of art music. The course of the achieved results will be disclosed by publication of articles, studies and monographs as well as the inclusion of obtained data to the international bank of music data (R.I.S.M.) likewise in domestic and foreign performing repertoire of some so far unknown and inaccessible valuable works of Croatian authors of the 18th, 19th and 20th century.]]></summary_en></project><project>
<id>4075</id><title_hr><![CDATA[Visokoenergijska astronomija gama-zraka teleskopima MAGIC i CTA]]></title_hr><title_en><![CDATA[ Very high energy gamma-ray astronomy with the MAGIC and CTA telescopes]]></title_en><user_id>6374</user_id><user_firstLast_name>Nikola Godinović</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2016-06</proposal_call><code>IP-2016-06-9782</code><acronim><![CDATA[MAGIC-CTA]]></acronim><duration>17.07.2017 - 16.06.2022</duration><status>Završio</status><financ_value>76.713,78 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, </scie_field_hr><scie_field_en>Physics, </scie_field_en><institution_hr><![CDATA[Sveučilište u Splitu, Fakultet elektrotehnike, strojarstva i brodogradnje]]></institution_hr><institution_en><![CDATA[University of Split, Faculty of Electrical Engineering, Mechanical Engineering and Naval Architecture]]></institution_en><team_members_id>4599, 6750, 5738, 19354, 55, 19301, 3652, 19423, 3127, 19815, 24438, 25265, 25065, </team_members_id><team_members_names><![CDATA[Iva  Šnidarić, Damir Lelas, Željka Marija  Bošnjak, Darko Zarić, Tihomir Surić, Tomislav Terzić, Ana Babić, Dijana Dominis Prester, Dario Hrupec, Saša Mićanović, Stefan Cikota, Lovro Pavletić, Marina Manganaro, ]]></team_members_names><keywords_hr><![CDATA[gama-zrake,  MAGIC, CTA, pulsari, aktivne galaktičke jezgre]]></keywords_hr><keywords_en><![CDATA[gamma rays, MAGIC, CTA, pulsars, active galactic nucleai]]></keywords_en><summary_hr><![CDATA[Visokoenergijska astronomija (VHE) gama-zraka izučava najsilovitije procese u svemiru. Ciljevi ovog projektnog prijedloga su izučavanje emisije VHE gama-zraka iz aktivnih galaktičkih jezgri (AGN), pulsara i proširenih izvora pomoću postojećih teleskopa MAGIC, zatim doprinos dizajnu, izgradnji i puštanju u rad teleskopskog niza Cherenkov Telescope Array (CTA), te analizi prvih podataka prikupljenih tim teleskopima. Analiza VHE gama-zraka iz pulsara omogućit će izučavanje akceleracijskih mehanizmima u magnetosferi neutronskih zvijezda. Za bolje razumijevanje emisijskih mehanizama VHE gama-zraka iz AGN provodit će se opažanja i analizirati korelacije između zračenja u različitim područjima elektromagnetskog spektra. Iako su izvori VHE gama-zraka većinom točkasti, znatan broj ima konačnu kutnu veličinu, za što ne postoji standardizirana analiza podataka. Kako bi se u potpunosti iskoristio potencijal teleskopa MAGIC, a pogotovo budućih teleskopa CTA čije će performance biti za red veličine bolje, razvit ćemo metodu analize proširenih izvora. To će omogućiti izučavanje morfologije izvora VHE gama-zraka, te detekciju drugih izvora opažanih u istom vidnom polju. Monte Carlo simulacijama optimizirat ćemo raspored teleskopa CTA te konfiguracija okidača, za koji će sustav biti najosjetljiviji. Da se dostignu zahtjevane performance Large Size Telescope (LST) (najveći teleskopi u nizu CTA, zrcalo promjera 23 m), nužno je poznavati položaj optičke osi teleskopa u odnosu na centar kamere s preciznošću od 5 lučnih sekundi. Dizajnirati ćemo, testirati, izgraditi i upogoniti sustav za praćenje položaja optičke osi LST teleskopa. Kako na opažani spektar  izvora gama-zraka  Čerenkovljevim teleskopima, utječe  atmosferska transmisija, razvit ćemo novu metodu raspodjele opažačkog vremena koju ćemo testirati na MAGIC teleskopima, a kasnije nadograditi i prilagoditi za potrebe CTA. Razvit ćemo i softverski alat za dugoročno praćenje performansi CTA teleskopa.]]></summary_hr><summary_en><![CDATA[Very high energy (VHE) gamma-ray astronomy studies the most violent processes in the Universe. Aims of this project proposal are study of VHE gamma-ray emission from active galactic nuclei (AGN), pulsars and extended sources using MAGIC telescopes, as well as participation in the design, construction and commissioning of the future Cherenkov Telescope Array (CTA) and analysis of the first data collected with these telescopes. Analysis of VHE gamma-rays from pulsars will enable study of the particle acceleration mechanism in pulsar magnetospheres. A better understanding of the VHE gamma-ray emission mechanisms in AGN will be achieved through observations and correlation analysis of data in different parts of the electromagnetic spectrum. Although mostly point-like, a significant number of VHE sources has a finite angular size, and are not covered by the standard data analysis. In order to fully exploit the potential of the MAGIC telescopes, and in particular the future CTA with even an order of magnitude higher performance, we will develop a method for extended sources data analysis. This will enable study of the morphology of VHE gamma-ray sources, and analysis of other sources observed in the same field of view. Monte Carlo studies will be used to optimize the CTA performance. To achieve the targeted performances of the Large Size Telescope (LST) of CTA, it is necessary to know the position of the telescope optical axis in respect to the centre of the camera with precession of 5 arc seconds. We will design, build and commission the position of the telescope optical axis monitoring system with the required precision. Since the gamma-ray spectra observed by Cherenkov telescopes depend on the atmospheric transmission, an improved observation scheduling method will be developed and implemented first in the MAGIC observation program, and later in the CTA. The software tool for long-term monitoring of the CTA telescope performances will be developed.]]></summary_en></project><project>
<id>4077</id><title_hr><![CDATA[Genetički i epigenetički biomarkeri urođene imunosti u KOPB-u i karcinomu pluća]]></title_hr><title_en><![CDATA[Genetic and epigenetic biomarkers of innate immunity in COPD and lung cancer]]></title_en><user_id>13083</user_id><user_firstLast_name>Jelena Knežević</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2016-06</proposal_call><code>IP-2016-06-1441</code><acronim><![CDATA[LungInflaCare]]></acronim><duration>25.05.2017 - 24.04.2022</duration><status>Završio</status><financ_value>131.793,75 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>3319, 5777, 3422, 3452, 5915, 27625, 27624, 27627, </team_members_id><team_members_names><![CDATA[Nada Oršolić, Gordana Bubanović, Marko Jakopovic, Miroslav Samarzija, Sven Seiwerth, Maja Šutić, Jurica Baranašić, Matea Kurtović, ]]></team_members_names><keywords_hr><![CDATA[KOPB, tumori pluća, urođena imunost, receptori, genetika, epigenetika, biomarkeri]]></keywords_hr><keywords_en><![CDATA[COPD, lung cancer, innate immunity, receptors, genetic, epigenetic, biomarkers]]></keywords_en><summary_hr><![CDATA[Kronična opstruktivna plućna bolest (KOPB) i tumori pluća vodeći su uzroci smrtnosti u svijetu. Usko su povezani i dijele zajedničke faktore rizika, pušenje i genetičku predispoziciju. Naime, samo 20% pušača razvije KOPB ili tumor pluća, dok prisutnost KOPB-a, definiranog smanjenim ekspiratornim volumenom zraka u 1 sekundi (FEV1), povećava rizik nastanka tumora pluća za 4 do 5 puta. Mehanistička povezanost KOPB-a i tumora pluća još uvijek je nedovoljno poznato, vjerojatno zbog heterogene kliničke slike obje bolesti.Urođeni imunološki odgovor neophodan je za održavanje zdravlja pluća i tkivne homeostaze, no nekontrolirana upala povezuje se s nastankom KOPB-a i tumora pluća. Stanice dišnog epitela i imunosne stanice eksprimiraju različite receptore za specifično prepoznavanje određenih uzoraka (eng. pattern recognition receptors, PPR) koji su sudjeluju u reakciji urođenog imunološkog odgovora na patogene i molekule koje mogu oštetiti tkivo. Poznato je da je dugotrajna i opsežna upala dovoljan rizični faktor za nastanak KOPB-a i karcinoma pluća. Međutim, još uvijek je potpuno nepoznato kako je genetička raznolikost receptora urođene imunosti povezana s regulacijom upale u plućima i dišnim putevima i kako ti procesi doprinose razvoju KOPB-a i nastanku tumora na molekularnoj i staničnoj razini. Također, histološka i molekularna heterogenost tumora pluća samog po sebi, otežava naše razumjevanje karcinogeneze i liječenja obje bolesti. Obzirom na veliku učestalost i snažnu povezanost KOPB-a i tumora pluća i nepostojanje adekvatne terapije za obje bolesti, identifikacija specifičnih genetičkih varijanti i rasvjetljavanje njihove uloge u bolesnim stanjima pridonijeti će liječenju bolesti na osobnom nivou. Stoga su specifični ciljevi predloženog projekta sažeti u dva radna područja:1. Identifikacija genetičkih i epigenetičkih faktora rizika zajedničkih KOPB-u i tumorima pluća2. Utvrđivanje mehanističke poveznice KOPB-a i TP-a uzimajući u obzir ulogu receptora urođene imunosti]]></summary_hr><summary_en><![CDATA[Chronic obstructive pulmonary disease (COPD) and lung cancer (LC) are leading causes of morbidity and mortality worldwide. They are closely related and share cigarette smoke as a common environmental risk factor. Genetic predisposition is also shared; only minority of smokers (20%) develops LC or COPD. The presence of COPD, defined as reduced forced expiratory volume in 1 second (FEV1), increases the risk to development of LC up to 4,5 fold. The mechanistic explanation of this finding is still poorly understood, likely due to heterogeneous nature of diseases. Innate immune response is essential for maintaining lung health and tissue homeostasis but unbalanced inflammation of lungs is associated with diseased conditions, such as COPD and LC. Pulmonary epithelial and immune cells are equipped with pattern recognition receptors (PRRs) able to initiate appropriate innate immune response to invading pathogens or tissue damage associated molecules. It is well known that excessive inflammation is sufficient to confer risk to both diseases. There is still lack of knowledge how genetic variability of innate immunity receptors orchestrate inflammation in lungs and how these processes contribute to development of both diseases, on molecular and cellular level. Also, the histological and molecular heterogeneity of LC, by itself, makes our understanding of carcinogenesis, as well as treatment of disease challenging. Because of global increase in COPD and LC prevalence, strong association of COPD with lung cancer and absence of specific therapeutic targets for both disease, identification of specific gene variants and their involvement in diseased conditions will improve disease treatment at personalized level. The specific aims of this project could be summarized in two work areas:1. Identification of shared genetic and epigenetic risk factors/biomarkers for COPD and LC2. Determination of common mechanistic link of COPD and LC considering the role of innate immunity receptors]]></summary_en></project><project>
<id>4079</id><title_hr><![CDATA[Kvantno-kemijski dizajn, priprava i biološka svojstva organometalnih derivata nukleobaza]]></title_hr><title_en><![CDATA[Quantum chemical design, synthesis and biological properties of organometallic nucleobase derivatives]]></title_en><user_id>5594</user_id><user_firstLast_name>Valerije Vrček</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2016-06</proposal_call><code>IP-2016-06-1137</code><acronim><![CDATA[OrDeN]]></acronim><duration>01.03.2017 - 28.02.2021</duration><status>Završio</status><financ_value>124.361,27 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, Biologija, </scie_field_hr><scie_field_en>Chemistry, Biology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Farmaceutsko-biokemijski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Pharmacy and Biochemistry]]></institution_en><team_members_id>4994, 2509, 2512, 1390, 355, 25235, </team_members_id><team_members_names><![CDATA[Davor Šakić, Senka Djaković, Jasmina Lapić, Ana Marija Marjanović, Srećko Kirin, Mateja Toma, ]]></team_members_names><keywords_hr><![CDATA[metalocen, nukleozid, bioaktivnost, elektrokemija, DFT računi]]></keywords_hr><keywords_en><![CDATA[metallocene, nucleoside, bioactivity, electrochemistry, DFT calculations]]></keywords_en><summary_hr><![CDATA[Organometalni derivati nukleobaza (OrDeN-i) nova su generacija konjugata u kojima su povezani metaloceni s temeljnim supstrukturnim elementima nasljeđivanja. Zbog elektrofornih i bioaktivnih svojstava OrDeN-i nalaze primjenu u (bio)analitičkoj i medicinskoj kemiji. Priprava OrDeN-a se temelji na sintetskoj kopulaciji organometalnog dijela i heterocikličke baze koristeći razne vrste mostova. Izbor fragmenata uglavnom je vođen pristupom što veće raznolikosti strukturnih motiva. U okviru ovog projekta strukturne modifikacije OrDeN-a bit će usmjerene prema pripravi derivata s izraženim elektrokemijskim i biološkim svojstvima. Eksperimentalnom dijelu istraživanja prethodit će opsežni kvantno-kemijski izračuni. Metodama teorije funkcionala gustoće (DFT metode) moguće je predvidjeti kemijska svojstva OrDeN-a, poput reaktivnosti/stabilnosti, redukcijskog potencijala, supstitucijskih i solvatacijskih efekata. Ti parametri mogu poslužiti za dizajn OrDeN-a s poboljšanim biološkim svojstvima. Koristit će se one DFT metode koje se tijekom sustavne procjene teorijskih modela (benchmarking) pokažu optimalnim u opisu bioorganometalnih modela za koje postoje eksperimentalni podaci. Novi strukturni elementi OrDeN-a uključuju funkcionalni most, niz homoanularnih supstituenata, odabrane parove metalocena  i nukleobaza, te bis-adukte. Novi most (linker) koji povezuje dva osnovna dijela OrDeN-a je karbonilna skupina i njezini reducirani oblici, hidroksilna i metilenska skupina. Elektronska komunikacija metalocena i nukleobaze ovisit će, dakle, o oksidacijskom stanju i hibridizaciji funkcionalnog mosta, a podešavat će se uvođenjem odabranih supstituenata na ciklopentadienilni prsten. Usporedba kvantno-kemijskih procjena s elektrokemijskim/ biološkim profilima pripravljenih modela upotrijebit će se u (re)dizajnu parova metalocena i nukleobaza, te ciljanih bis-adukata OrDeN-a.]]></summary_hr><summary_en><![CDATA[Organometallic nucleobase derivatives (OrDeNs) correspond to a new generation of conjugates in which metallocenes are linked to the basic structural elements of heredity. Due to their electrophoric and bioactive properties, OrDeNs are of use in (bio)analytical and medicinal chemistry. The preparation of OrDeNs is based on the copulation reaction between the organometallic part with a heterocyclic base, by using different linkers. The choice of fragments usually follows the target of the ever-growing diversity of structural motifs. In this project all modifications of OrDeNs structures will be directed toward derivatives with marked electrochemical and biological properties. An extensive quantum chemical study will precede the experimental part of the research. By using the density functional theory methods (DFT methods) the chemical properties of OrDeNs, such as stability/reactivity, reduction potential, substituent and solvation effects, can be predicted. These parameters can assist in designing OrDeNs with enhanced bioactivity. A benchmark study in evaluating DFT methods will be performed. DFT methods which are superior in the description of biorganometallic models (for which experimental data are known) will be used to study OrDeNs. New structural elements in OrDeNs include the functional linker, a series of homoannular substituents, selected metallocene-nucleobase pairs, and bis-adducts. A new linker type, which connects the two constitutional parts in OrDeNs, is a carbonyl group and its reduced forms, hydroxyl and methylene groups. The electron communication between metallocene and nucleobase depends, therefore, on the oxidation state and hybridization of the functional linker, and can be tuned by using selected substituents at the cyclopentadienyl ring. The interplay between quantum chemical estimates and electrochemical/biological profiles for model compounds will advance the (re)design of new metallocenes-nucleobase pairs and bis-adducts of OrDeNs.]]></summary_en></project><project>
<id>4081</id><title_hr><![CDATA[MATH-BTB proteini kao regulatori transkripcije i RNA posredovane metilacije DNA u biljnom razvitku]]></title_hr><title_en><![CDATA[MATH-BTB proteins as switches between transcription and RNA-directed DNA methylation during plant development ]]></title_en><user_id>3746</user_id><user_firstLast_name>Dunja Leljak-Levanić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2016-06</proposal_call><code>IP-2016-06-6229</code><acronim><![CDATA[PHYTOMETHDEV]]></acronim><duration>01.03.2017 - 31.12.2021</duration><status>Završio</status><financ_value>132.722,81 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Biologija, </scie_field_hr><scie_field_en>Biology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>4217, 791, 3735, 5012, 19214, 3121, 5596, 19376, 6193, 24301, 25338, 28653, 28868, 25017, 25016, </team_members_id><team_members_names><![CDATA[NATAŠA BAUER, Branka Salopek Sondi, Nenad Malenica, Snježana Mihaljević, Željka Vidaković-Cifrek, Dubravko Pavoković, Vedrana Vičić Bočkor, Kristina Majsec, Lidija Begović, Lucija Markulin, Tamara Vuk, Mirta Tokić, Sandra Vitko, Andreja Škiljaica, Mateja Jagić, ]]></team_members_names><keywords_hr><![CDATA[metilacija DNA, RdDM, MATH-BTB, embriogeneza, stres, biljke]]></keywords_hr><keywords_en><![CDATA[DNA methylation, RdDM, MATH-BTB, embryogenesis, stress, plants]]></keywords_en><summary_hr><![CDATA[Metilacija DNA jedan je od nekoliko epigenetičkih mehanizama kontrole ekspresije gena. U biljaka raznolikost epigenetičkih mehanizama ima, osim u regulaciji razvojnih procesa, važnu ulogu u fenotipskoj i fiziološkoj prilagodljivosti, te sposobnosti biljaka da prežive i razmnožavaju se u promjenjivom okolišu. Metilacija biljne DNA odvija se na sljedovima CG, CHG i asimetričnom CHH (H simbol za A, C ili T), a svaki od njih ima različite &#39;&#39;genetičke zahtjeve&#39;&#39; za očuvanje. Nesimetrična metilacija CHH ne može se održati i zahtijeva de novo metilaciju u svakom staničnom ciklusu. Proces kojim se to ostvaruje je metilacija DNA usmjerena s RNA (RdDM). Dvije RNA polimeraze specifične za biljke, Pol IV i Pol V sintetiziraju male interferirajuće RNA, odnosno dugačke nekodirajuće molekule RNA, važne za RNA-DNA prepoznavanje. Kompleks DDR predstavlja proteinski kompleks za koji se smatra da je odgovoran za dovođenje enzima Pol V na mjesto regulacije gena, no mehanizam specifičnosti nije jasan. Naši preliminarni rezultati ukazuju da proteini MATH-BTB iz uročnjaka stupaju u interakciju s kompleksom DDR, te tako mogu posredovati u pozicioniranju sustava RdDM. Najnovija otkrića ukazuju da su supstrati proteina BPM transkripcijski faktori. Proteini s ovakvim interakcijskim mogućnostima imaju potencijal  održavanja ravnoteže između metilacije (posredovane Pol V) i transkripcije (posredovane Pol II). Glavni cilj projekta je rasvjetljavanje funkcionalne uloge proteina BPM u regulaciji transkripcije i RdDM-a kao i moguće uloge u biljnoj embriogenezi i prilagodbi na stresne uvjete. Posebna pozornost biti će dana identifikaciji gena čija je transkripcija ili RdDM metilacija uravnotežena proteinom BPM1 (kromatinska imunoprecipitacija-ChIP, ChIP-sekvenciranje). Nadalje, metilacijski uzorak (bisulfitno sekvenciranje) odabranih gena će biti povezan s njihovom ekspresijom (Q-PCR), te s embriogenezom i odgovorom biljaka na stres u linijama s promijenjenim sustavom RdDM ili ekspresijom gena BPM.]]></summary_hr><summary_en><![CDATA[DNA methylation is one of several epigenetic mechanisms used by cells to control gene expression. In plants epigenetic diversity, besides regulating development, presumably contributes in plant phenotypic and physiological plasticity and the ability to survive and reproduce in unpredictable environments. Plant DNA methylation occurs at CG, CHG and nonsymmetrical CHH (where H is A, C or T) sequences, each of which has different genetic requirements for its preservation. Nonsymmetrical CHH methylation cannot be sustained by the maintenance machinery and require de novo methylation in each cell cycle through a process called RNA-directed DNA methylation (RdDM). Two plant specific RNA polymerases, Pol IV and Pol V, produce small interfering RNAs and long non-coding RNAs respectively, which are important for RNA-DNA target sequence recognition. The DDR complex represents a major determinant that is proposed to be responsible for recruitment of the Pol V enzyme to the specific loci, but the mechanism is still not clear. Our preliminary results indicate that Arabidopsis MATH-BTB proteins recognize and interact with the DDR complex and thus might mediate the positioning of RdDM machinery. Recent findings indicate that substrates of BPM proteins are predominantly transcription factors. These two properties of a single BPM protein suggest its capacity to act as a control switch between methylation (mediated by Pol V) and transcription (mediated by Pol II). The main goal of this project is to elucidate the functional roles of BPMs in orchestrating transcription and RdDM, and its possible role in plant embryogenesis and stress adaptation. Particular focus will be placed to identification of genes whose transcription or RdDM methylation is affected by BPMs (by ChIP and ChIP seq). Further, methylation context (bisulfite sequencing) of selected genes will be correlated with their expression (Q-PCR) and with embryogeneis and stress responses in different RdDM and BPM mutant lines.]]></summary_en></project><project>
<id>4084</id><title_hr><![CDATA[Karakterizacija kandidat gena za kongenitalne anomalije bubrega i urotrakta (CAKUT) tijekom razvoja u miša i čovjeka]]></title_hr><title_en><![CDATA[Characterization of Congenital Anomalies of the Kidney and the Urinary tract (CAKUT) candidate genes during mouse and human development]]></title_en><user_id>12479</user_id><user_firstLast_name>Katarina Vukojević</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2016-06</proposal_call><code>IP-2016-06-2575</code><acronim><![CDATA[CAKUT]]></acronim><duration>01.02.2018 - 28.02.2023</duration><status>Završio</status><financ_value>132.722,81 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Splitu, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Split School of Medicine]]></institution_en><team_members_id>4338, 19247, 19253, 11243, 19276, 19308, 13069, 19279, 19332, 19378, 4839, 12795, 19571, 19588, 25216, 28630, 25196, 856258, 1192, 26019, 4348, 26117, 865336, 865521, 865520, 26134, </team_members_id><team_members_names><![CDATA[Sandra Kostić, Snježana Mardešić, Fila Raguž, Sandra  Zekić Tomaš, Nenad Kunac, Mirna Saraga-Babić, Ivana Restović, Violeta Šoljić, Boris Kablar, Simone Sanna-Cherchi, Merica Glavina Durdov, Marijan Saraga, Joško Petričević, Vlatka Martinović, Anita Muić, Mirela Lozić Lozić, Ejazul  Haque, Nela Kelam, Ivana  Bočina, Marija Jurić, Natalija Filipović, Ivona Kosović, Mirjana Polović, Vlatka Paštar Paštar, Martina Vukoja, Ivana Šolić Šolić, ]]></team_members_names><keywords_hr><![CDATA[kongenitalne anomalije bubrega i urotrakta, genetika, imunohistokemija, imunofluorescencija, knock-out miš]]></keywords_hr><keywords_en><![CDATA[congenital anomalies of the kidney and urinary tract, genetics, immunohistochemistry, immunofluorescence, knock-out mice]]></keywords_en><summary_hr><![CDATA[Kongenitalne anomalije bubrega i mokraćnog sustava (CAKUT) u 40-50% pedijatrijskih bolesnika dovode do krajnjeg stadija zatajenja bubrega. Među kategorijama CAKUTa, kongenitalna opstruktivna uropatija predstavlja zajednički i teški oblik malformacija. Zbog nedostatka temeljnog uvida o njegovoj primarnoj patogenezi, dijagnostičke i terapijske mogućnosti su ograničene.Nedavno smo identificirali dominantne štetne mutacije u DSTYK genu koji kodira dvostruku serin-treonin i tirozin protein-kinazu, kod osoba s malformacijama mokraćnog sustava koristeći sekvenciranje exoma u kombinaciji s funkcionalnim modelom u zebraste ribice (New Engl J Med 2013). Protein kodiran DSTYK genom djeluje kao pozitivan regulator u signalizaciji faktora rasta fibroblasta (FGF), tijekom nefrogeneze. Osim toga, identificirali smo pet novih gena kandidata za CAKUT koji su pokazali ekspresiju u miša i čovjeka tijekom razvoja urinarnog trakta. Među tim genima, DLG1 i KIF12 su vjerojatno susceptibilni geni za razvoj CAKUTa kod ljudi (Kidney Int 2015).Ovdje predlažemo početnu karakterizaciju funkcije novih gena kandidata za CAKUT tijekom embrionalnog razvoja, nefrogeneze i razvoja uretera. Prvo ćemo istraživati profil vremenskog-prostornog izražaja i ko-lokaliziranje kandidat gena za CAKUT u različitim fazama embriogeneze u tkivima normalnih miševa i ljudskog zametka te bubrega i mokraćnog sustava u razvoju i usporediti markere nefrogeneze i razvoja uretera. Zatim ćemo odabrati jedan visoko prioritetni novi kandidat gen te generirati i okarakterizirati miša koji nosi mutaciju u ovom genu od interesa (knockout miš), zatim ćemo identificirati mehanizme kojima mutacije u ovom genu dovode do malformacija urinarnog trakta kod ljudi.Ova studija je osmišljena kako bi se okarakterizirali funkcionalni učinci kandidat gena za CAKUT u razvoju mokraćnih puteva, identificirati disregulacijske putove i na kraju osmisliti nove dijagnostičke alate i terapijske strategije za taj učestali oblik zatajenja bubrega.]]></summary_hr><summary_en><![CDATA[Congenital Anomalies of the Kidney and the Urinary Tract (CAKUT) account for 40-50% of pediatric end-stage kidney failure. Among CAKUT categories, congenital obstructive uropathy represents a common and severe form. Due to paucity of fundamental insight about its primary pathogenesis, diagnostic and therapeutic options are severely limited.  We recently identified dominant deleterious mutations in DSTYK, encoding a dual serine-threonine and tyrosine protein-kinase, in individuals with urinary tract malformations using exome sequencing combined to functional modeling in zebrafish (New Engl J Med 2013). The protein encoded by DSTYK acts as a positive regulator of fibroblast growth factor (FGF) signaling during nephrogenesis. Additionally, we identified five novel candidate genes for CAKUT that showed specific expression in the human and mouse developing urinary tract. Among these genes, DLG1 and KIF12 are likely novel susceptibility genes for CAKUT in humans (Kidney Int 2015).Here we propose to initially characterize the function of novel CAKUT candidate genes during embryonic development, nephrogenesis and ureteric development. We will first study the candidate genes temporal-spatial expression and colocalization profile during different stages of embryogenesis in normal mouse and human embryonic tissue and in developing kidneys and urinary tract and compare to markers of nephrogenesis and ureteric development. We will next choose one high-priority novel candidate gene and generate and characterize mouse harboring mutation in a gene of interest (knockout mice) to identify the mechanisms by which mutations in this gene lead to urinary tract malformations in humans. This study is designed to characterize the functional effect of CAKUT candidate genes in urinary tract development, to identify dysregulated pathways, and, ultimately, to devise novel diagnostic tool and therapeutic strategies for this common form of renal failure.]]></summary_en></project><project>
<id>4089</id><title_hr><![CDATA[Sinteza naprednih anorganskih katalizatora s povećanim brojem kiselih mjesta]]></title_hr><title_en><![CDATA[Synthesis of Advanced Inorganic Catalysts of Increased Number of Acid Sites]]></title_en><user_id>609</user_id><user_firstLast_name>Josip Bronić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2016-06</proposal_call><code>IP-2016-06-2214</code><acronim><![CDATA[SAdInCat]]></acronim><duration>01.03.2017 - 31.12.2021</duration><status>Završio</status><financ_value>122.635,87 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, </scie_field_hr><scie_field_en>Chemistry, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>5634, 692, 623, 1073, 19249, 19656, 25291, 28957, </team_members_id><team_members_names><![CDATA[Tatjana Antonić Jelić, Sanja Bosnar, Andreas Puškarić, Stjepko Krehula, Girolamo Giordano, Boris Subotić, Glorija Medak, Ivana Landripet, ]]></team_members_names><keywords_hr><![CDATA[zeolitni katalizatori, hijerarhijski zeoliti, hibridni materijal, nano-zeoliti, mokra impregnacija, converzija metanola u olefine, ]]></keywords_hr><keywords_en><![CDATA[zeolite catalyst, hierarchical zeolites, hybrid materijal,  nano-zeolites, wet impregnation, methanol to olefin conversion, ]]></keywords_en><summary_hr><![CDATA[Zeoliti su mikroporozni alumino-silikatni materijali vrlo dobro definirane kristalne strukture i termičke stabilnosti. Zahvaljujući svojoj strukturi, kanali i otvori pora mogu biti raznih veličina (0.2-1.3 nm) i oblika. Broj dostupnih Lewis-ovih (kadkad i Bronsted-ovih) kiselih mjesta na čvrstim katalzatorima, kao što su zeoliti, je od najveće važnosti za efikasnost katalizirane organske reakcije. U cilju razjašnjenja utjecaja različitih zeolitnih struktura (MFI, MOR, BEA, FAU) na katalitička svojstva za pretvorbu metanola u olefin, sintetizirat će se kristali različitih zeolita (ZSM-5, mordentie, beta, ZY) mikrometarske veličine. Poboljšanje njihovih katalitičkih mogućnosti će se realizirati sustavnim studiranjem preko dva pristupa: - povećanjem dostupne površine na kristalima i - povećanjem broja kiselih mjesta.Površina kristala može se povećati kroz redukciju njihove veličine (kroz sintezu nanometarskih kristala) ili pravljenjem većih pora na kristalima mikrometarske veličine. Mezoporoznost kristala će se postići sintezom hierarhijskih zeolita koristeći dva (ili više) templata za sintezu, kao i tehnikom dealuminacije/desilikacije. Drugi način povećanja broja kiselih mjesta u pripravljenim zeolitima je uvođenje određenih kationa metala (Ti, Zr, Fe, Sn) koristeći ionsku zamjenu u čvrstom stanju metodom mljvenja i/ili mokrom impregnacijom. Broj katalitičkih kiselih mjesta će se određivati uporabom vacuum FTIR spektroskopije adsorbiranog piridina ili sličnih organskih molekula.Dodatni post-sintetski tretman pripravljenih hierarhijskih zeolita, provodit će se ugradnjom nanometarskih čestica metalnih-oksida (priređenih sol-gel postupkom) u njih da čine hibridne (kompozitne) katalizatore. Mnoge tehnike/metode će se koristiti za karakterizaciju strukturnih, čestičnih i katalitičkih svojstava uzoraka: PXRD, AAS, OM, SEM, TEM, LLS, FTIR, DR-UV/Vis, NMR, TG-DTG, N2 adsorption/desorption, PALS.]]></summary_hr><summary_en><![CDATA[Zeolites are microporous alumino-silicate materials of very well defined crystal structure and thermal stability. Due to their structure, a crystal channels and pore openings can be of various size (0.2-1.3 nm) and shape.The number of available Lewis&#39; (sometimes Bronsted) acid sites at solid state catalysts, such as zeolites, is crucial for efficiency of catalysed organic reactions. In order to elucidate the role of different zeolite structures (MFI, MOR, BEA, FAU) on catalytic properties for methanol to olefin conversion, various micrometer sized zeolite crystals (ZSM-5, mordentie, beta, ZY) will be synthesized. Improvement of their catalytic abilities will be realized by systematic study via two approaches: - increase of available surface at crystals, and - increase of the number of acid sites.The crystals surface can be enlarged through reduction of its size (by synthesis of nanometer sized crystals) or by creation of larger pores on micrometer sized crystals. Mesoporosity of the crystals will be obtained by synthesis of hierarchical zeolites using dual (or multi) template synthesis and by dealumination/desilication technique. Another way to increase the number of acid sits in prepared zeolites is introduction of certain metal cations (Ti, Zr, Fe, Sn) exploiting solid state ion exchange via grinding or/and via wet impregnation. The number of catalytic acid sites will be determined using vacuum FTIR spectroscopy of adsorbed pyridine or similar probe molecules.Additional post-synthesis treatment of obtained hierarchical zeolites will be done through incorporation of the nanometer sized metal-oxides (obtained by sol-gel method) to form hybrid (composite) catalyst. Many techniques/methods will be used for characterization of samples structural, particulate and catalytic properties, such as: PXRD, AAS, OM, SEM, TEM, LLS, FTIR, NMR, DR-UV/Vis, TG-DTG, N2 adsorption/desorption, PALS.]]></summary_en></project><project>
<id>4097</id><title_hr><![CDATA[Monitoring rezistentnosti štetnika: nove metode detekcije i učinkovite strategije upravljanja rezistentnošću]]></title_hr><title_en><![CDATA[Monitoring of Insect Pest resistance: Novel Approach for Detection and Effective Resistance Management Strategies]]></title_en><user_id>12674</user_id><user_firstLast_name>Renata Bažok</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2016-06</proposal_call><code>IP-2016-06-7458</code><acronim><![CDATA[MONPERES]]></acronim><duration>01.03.2017 - 14.08.2021</duration><status>Završio</status><financ_value>132.497,18 eur</financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Biotehnologija, Poljoprivreda, </scie_field_hr><scie_field_en>Biotechnology, Agriculture, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Agronomski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Agriculture]]></institution_en><team_members_id>19312, 12814, 12868, 12867, 19317, 12781, 12863, 13560, 19319, 24311, 24310, 855335, </team_members_id><team_members_names><![CDATA[Božena  Barić, Dinka Grubišić, Darija Lemić, Maja Čačija, Ivana Pajač Živković, Hugo Benitez, Katarina Mikac, Tóth Miklós, Helena Virić Gašparić, Martina Kadoić Balaško, Dijana Fuchs, Bastian Christoph Goldel, ]]></team_members_names><keywords_hr><![CDATA[biotest, metode detekcije, genetski monitoring, geometrijsko morfometrijska analiza, rezistentnost štetnika, upravljanje rezistentnošću]]></keywords_hr><keywords_en><![CDATA[ bioassay, detection methods, genetic monitoring, geometric morphometric analyse, pest resistance, restitance management strategies                   ]]></keywords_en><summary_hr><![CDATA[Proizvodnju važnih kultura u Hrvatskoj (kukuruz, krumpir i jabuka) ugrožavaju brojni štetnici, od kojih su najvažniji kukuruzna zlatica (Diabrotica virgifera virgifera LeConte) (WCR), krumpirova zlatica (Leptinotarsa decemlineata Say) (CPB) i jabukov savijač (Cydia pomonella L.) (CM). Navedene vrste razvile su rezistentnost na insekticide ili na strategije suzbijanja. Sustavno praćenje rezistentnosti štetnika u Hrvatskoj ne postoji. Za dokazivanje rezistentnosti uobičajeno se koriste biotestovi, biokemijski i molekularni testovi koji imaju određene prednosti, ali i nedostatke.Opći cilj predloženog projekta je otkriti i pratiti rezistentne populacije štetnika u Hrvatskoj, optimizirati genetske metode i istražiti pouzdanost geometrijsko-morfometrijskih metoda u otkrivanju rezistentnosti, te održati učinkovito suzbijanje uporabom odgovarajućih antirezistentnih strategija usmjerenih na najvažnije štetnike ratarskih (WCR, CPB) i voćarskih (CM) kultura.Specifični ciljevi projekta su:O1) u poljskim uvjetima Hrvatske organizirati sustavni monitoring rezistentnosti CPB i CM; O2) optimizirati genetske metode za otkrivanje varijabilnosti povezanih s razvojem rezistentnosti WCR, CPB i CM;O3) istražiti mogućnost korištenja geometrijsko-morfometrijskih metoda za otkrivanje razvoja rezistentnosti istraživanih štetnika;O4) utvrditi mogućnost korištenja alternativnih metoda suzbijanja; O5) osigurati prijenos znanja i spoznaja do ključnih interesnih skupina. Očekivani rezultati: R1) osigurani pouzdani podaci o pojavi i distribuciji rezistentnih populacija CPB i CM u Hrvatskoj; R2) istražene, razvijene i optimizirane genetske i R3) geometrijsko-morfometrijske metode za otkrivanje i praćenje nerezistentnih i rezistentnih populacija CPB, WCR i CM; R4) osigurani podaci o alternativnim (uključujući nekemijske) metodama i strategijama suzbijanja i R5) stečena znanja i spoznaje predočene interesnim skupinama. Osigurana potpora provedbi novo razvijenih strategija u poljoprivrednu praksu.]]></summary_hr><summary_en><![CDATA[The production of the important crops, maize, potato and apples in Croatia is endangered by many of insect pests out of which very important are Western corn rootworm (Diabrotica virgifera virgifera LeConte) (WCR), Colorado potato beetle (Leptinotarsa decemlineata Say) (CPB) and Codling moth (Cydia pomonella L.) (CM). These pests have shown resistance to insecticides or to management strategies. No systematic monitoring of pest resistance is carried out in Croatia. Methods available for resistance detection  (bioassays, biochemical or molecular) have positive and negative points. The main objective is to detect and monitor the resistant variants in Croatia, optimize genetic and explore reliability of morphometric based survey techniques for the detection of resistance, and to maintain effective control using appropriate resistance manageemnt strategies of WCR, CPB and CM. Specific objectives are: O1) to conduct systematic field monitoring of resistance in CPB  and CM in Croatia; O2) to optimize techniques to detect genetic differentiation correlated with resistance development in WCR, CPB and CM; O3) to explore the potential of geometric morphometric techniques in order to detect resistance development in investigated pests;O4) to establish the potential for use of alternative control options for investigated pests.O5) to disseminate gained knowledge to key stakeholders The expected results are: R1 provided reliable data on the presence and distribution of resistant variants of CPB and CM in Croatia; R2) The genetic and R3) morphometric based survey techniques to detect and monitor the movement of non-resistant and resistant variants of CPB, WCR and CM explored, developed and optimized; R4) the summarized information on alternative (including non-chemical) control options and strategies provided and R5) The gained knowledge disseminated to key stakeholders. Provided support to implementation of newly developed strategies into the agricultural practice.]]></summary_en></project><project>
<id>4101</id><title_hr><![CDATA[Metodološki okvir za učinkovito upravljanje energijom s pomoću inteligentne podatkovne analitike]]></title_hr><title_en><![CDATA[Methodological Framework for Efficient Energy Management by Intelligent Data Analytics ]]></title_en><user_id>6088</user_id><user_firstLast_name>Josip Mesaric</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2016-06</proposal_call><code>IP-2016-06-8350</code><acronim><![CDATA[MERIDA]]></acronim><duration>01.01.2017 - 28.02.2021</duration><status>Završio</status><financ_value>73.217,07 eur</financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Ekonomija, </scie_field_hr><scie_field_en>Economy, </scie_field_en><institution_hr><![CDATA[Sveučilište Josipa Jurja Strossmayera u Osijeku, Ekonomski fakultet u Osijeku]]></institution_hr><institution_en><![CDATA[Josip Juraj Strossmayer University of Osijek, Faculty of Economics]]></institution_en><team_members_id>895, 2941, 6088, 20226, 20250, 2550, 6717, 6410, 6353, 25355, 26583, 855430, </team_members_id><team_members_names><![CDATA[Rudolf Scitovski, Hrvoje Krstić, Josip Mesaric, Davor Dujak, Zlatko Tonković, Domagoj Sajter, Dario Šebalj, Adela  Has, Saša Mitrović, Marinela Knežević, Sanja Scitovski, Kristina Hodak, ]]></team_members_names><keywords_hr><![CDATA[podatkovna analitka, strojno učenje, energetska učinkovitost, troškovi energije, lanac opskrbe, simulacije, metodološki okvir]]></keywords_hr><keywords_en><![CDATA[data analytics, machine learning, energy efficiency, energy cost, energy supply chain, simulation, methodological framework]]></keywords_en><summary_hr><![CDATA[Iako u Hrvatskoj i u drugim zemljama EU postoje strategije i nacionalni planovi energetske učinkovitosti kojima se određuju i prate ciljevi smanjenja potrošnje energije,  podaci se nedovoljno znanstveno analiziraju u svrhu učinkovitijeg upravljanja energijom, a posebice nedostaje uporaba metoda strojnog učenja. Upravo je svrha projekta provesti inteligentnu analizu podataka o energetskoj učinkovitosti zgrada u javnom sektoru, ponuditi metode i modele koji bi omogućili bolje planiranje nacionalne energetske politike te upravljanje troškovima. Ciljevi projekta su: (1) identificirati karakteristične skupine (klastere) javnih zgrada za koje se prate energetske karakteristike, mjere za poboljšanje tih karakteristika i potrošnja energije, (2) uporabom podatkovne analitike razviti metodološki okvir za  predviđanja i analizu utjecaja pojedinih varijabli na uštede u potrošnji energije, emisiji CO2 i troškovima, (3) naprednim analitičkim metodama procijeniti financijsku isplativost i dugoročne financijske učinke mjera za povećanje energetske učinkovitosti i (4) simulacijskim modeliranjem predložiti prilagodbe modela lanca opskrbe prirodnog plina kao jednog od važnijih energenata u javnom sektoru. Za dobivanje modela testirat će se metode strojnog učenja, kao što su klaster analize, neuronske mreže, stabla odlučivanja, metoda potpornih vektora i druge, zatim financijske metode, mapiranje lanca opskrbe i simulacijsko modeliranje. Statističkim testovima izabrat će se metode koje generiraju preciznije modele i predložiti njihova integracija u nov metodološki okvir kao znanstveni doprinos projekta.  Osim toga, otkrit će se utjecaj pojedinih ulaznih varijabli na potrošnju energije i trošak te stvoriti jedinstvena baza podataka energetske učinkovitosti koja će služiti i za buduće analize. Osim istraživača, korisnici ovog projekta mogu biti državne institucije davatelji subvencija, donositelji i provoditelji energetske politike, korisnici zgrada i pružatelji energetskih usluga.]]></summary_hr><summary_en><![CDATA[Although there are strategies and national plans of energy efficiency in Croatia and other EU countries, which determine and monitor the objectives of reducing energy consumption, the data have not been scientifically analyzed enough for the purpose of efficient energy management, and there is a lack of machine learning methods usage.  The purpose of the project is to conduct an intelligent data analysis on public buildings energy efficiency, and to suggest methods and models that will enable better planning of national energy policy. The aims of the project are: (1) to identify characteristic clusters of public buildings for which data on energetic characteristics, measures for improving those characteristics, and energy consumption are captured, (2) to develop a methodological framework for predictions and analyses of variable influence on energy consumption, CO2 emission and cost, by using intelligent data analytics,  (3) to estimate financial compensation and long-term financial effects of measures for increasing energy efficiency by advanced analytical methods, and (4) to suggest improvements in supply chain of natural gas as one of the important energy sources in building sector. In order to obtain models, methods of machine learning will be tested such as cluster analysis, neural networks, decision trees, support vector machines, and others, as well as financial methods, supply chain mapping, and simulation modelling.  By using statistical tests, the more successful methods will be suggested for integration in the methodological framework that will be the major scientific contribution. In addition, the influence of specific input variables on energy consumption and cost will be revealed, and a unique database of energy efficiency will be established that could be used for future data analyses. Besides researchers, the users of this project could be state institutions providers of subventions, policy makers, managers in public sector, and energy providers.]]></summary_en></project><project>
<id>4103</id><title_hr><![CDATA[Operatori na C*-algebrama i Hilbertovim modulima]]></title_hr><title_en><![CDATA[Operators on C*-algebras and Hilbert modules]]></title_en><user_id>19162</user_id><user_firstLast_name>Damir Bakić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2016-06</proposal_call><code>IP-2016-06-1046</code><acronim><![CDATA[OCAHM]]></acronim><duration>15.03.2017 - 14.03.2021</duration><status>Završio</status><financ_value>64.000,27 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Matematika, </scie_field_hr><scie_field_en>Mathematics, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>19272, 19294, 7717, 19465, 19498, 19437, 19270, 19374, </team_members_id><team_members_names><![CDATA[Ljiljana Arambašić, Tomislav Berić, Dijana Ilišević, Ilja  Gogić, Pavle Goldstein, Boris Guljaš, Rajna Rajić, Luka Žunić, ]]></team_members_names><keywords_hr><![CDATA[C*-algebra, Hilbertov C*-modul, derivacija, automorfizam, lokalni multiplikator, elementaran operator, bazni okvir, ortogonalnost, Wignerova jednadžba]]></keywords_hr><keywords_en><![CDATA[C*-algebra, Hilbert C*-module, derivation, automorphism, local multiplier, elementary operator, frame,  orthogonality, Wigner&#39;s equation]]></keywords_en><summary_hr><![CDATA[U predloženom projektu istraživat ćemo neke klase operatora na C*-algebrama i Hilbertovim C*-modulima. Prvo, istraživat će se skupovi derivacija, automorfizama i elementarnih operatora na jediničnim C*-algebrama; posebno, međusobni odnosi zatvarača tih skupova u operatorskoj i potpuno ograničenoj (cb) normi. Vezani dio istraživanja je analiza elementarnih operatora na Hilbertovim C*-modulima. Namjeravamo naći prikladna poopćenja formula (poznatih za C*-algebre) za normu i cb-normu takvih operatora u terminima njihovih koeficijenata. Također namjeravamo studirati neke druge klase operatora na C*-algebrama i Hilbertovim C*-modulima: operatore &#39;&#39;konačnog ranga&#39;&#39; i aproksimacije takvim operatorima, n-cirkularne projektore te unitarne/antiunitarne operatore (u vezi s generalizacijama i analizom stabilnosti Wignerove jednadžbe). Povezano područje koje namjeravamo istražiti je klasa preslikavanja na C*-algebrama i Hilbertovim C*-modulima koja čuvaju ortogonalnost s obzirom na različite koncepte ortogonalnosti.U našem proučavanju operatora na Hilbertovim C*-modulima namjeravamo koristiti bazne okvire i vanjske bazne okvire takvih modula kao osnovni alat. Vanjski bazni okviri Hilbertovih C*-modula nedavno su uvedeni i prepoznati kao prirodno popćenje baznih okvira koje popunjava neke praznine u modularnoj teoriji baznih okvira. Planiramo sistematično koristiti egzistenciju baznih okvira i vanjskih baznih okvira u svim prebrojivo generiranim modulima i njihovo rekonstrukcijsko svojstvo kako bismo stekli novi uvid u transformacije modula i strukturu skupova nekih klasa modularnih preslikavanja. Konačno, namjeravamo se posvetiti i nekim otvorenim pitanjima u samoj teoriji modularnih baznih okvira poput korespondencije ograničenih preslikavanja i Besselovih nizova, perturbacija baznih okvira i opisa (zajedno s metodama konstrukcije) dualnih baznih okvira s posebnim svojstvima.]]></summary_hr><summary_en><![CDATA[In the proposed project we shall study some classes of operators on C*-algebras and Hilbert C*-modules. First, we will study the sets of derivations, automorphisms and elementary operators on unital C*-algebras; in particular, the interrelations of the closures of these sets in the operator and completely bounded (cb) norm. A related part of the project is the analysis of elementary operators on Hilbert C*-modules. We aim to find appropriate generalizations of formulae (known for C*-algebras) for the norm and cb-norm of such operators in terms of their coefficients.  We also plan to study some other classes of operators on C*-algebras and Hilbert C*-modules: &#39;&#39;finite rank&#39;&#39; operators and approximations by such operators, n-circular projections, and unitary/anti-unitary operators (in connection with generalizations and analysis of the stability of Wigner&#39;s equation). A related topic which we aim to explore is the class of orthogonality preserving maps on C*-algebras and Hilbert C*-modules, with respect to various concepts of orthogonality. In our study of operators on Hilbert C*-modules we plan to use frames and outer frames for such modules as a pivotal tool. Recently, outer frames for Hilbert C*-modules are introduced and recognized as a natural generalization of frames that bridges some gaps in the modular frame theory. We plan to use systematically the existence of frames and outer frames in all countably generated modules and their reconstruction property to obtain a new insight into the properties of transformations of Hilbert C*-modules and into the structure of sets of some classes of modular maps. Finally, we aim to address some open questions in the modular frame theory itself such as the correspondence of bounded operators and Bessel sequences, perturbations of frames and description (together with construction methods) of dual frames with special properties.]]></summary_en></project><project>
<id>4108</id><title_hr><![CDATA[Vrijednosti i odluke na kraju života]]></title_hr><title_en><![CDATA[Values and Decisions at the End of Life]]></title_en><user_id>5397</user_id><user_firstLast_name>Ana Borovečki</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2016-06</proposal_call><code>IP-2016-06-2721</code><acronim><![CDATA[VAL-DE-END]]></acronim><duration>01.09.2017 - 28.02.2022</duration><status>Završio</status><financ_value>51.297,37 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo, Društvene znanosti, Humanističke znanosti, </scie_area_hr><scie_area_en>Biomedicine and health sciences, Social sciences, Humanities, </scie_area_en><scie_field_hr>Integrativna bioetika, Javno zdravstvo i zdravstvena zaštita, Sociologija, Psihologija, Filozofija, Religijske znanosti, </scie_field_hr><scie_field_en>Integrative bioethics, Public health and health services, Sociology, Psychology, Philosophy, Religion, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb School of Medicine]]></institution_en><team_members_id>5444, 5528, 5586, 5993, 6105, 5826, 5452, 19271, 19284, 6204, 19295, 19283, 19382, 19472, 25062, 25041, 25013, 25060, </team_members_id><team_members_names><![CDATA[Lovorka Brajković, Hrvoje Premuž, Marko Ćurković, Suzana Vuletić, Bert Gordijn, Sanja Babić-Bosanac, Stjepan Oreskovic, Diana Špoljar, Chris Gastmans, Tonci Matulic, Marijana Braš, Štefan Grosek, Milivoj Novak, Dinko Tonković, Filip Rubić, Boris Filipović-Grčić, Ružica Kramarić, Sunčana Janković, ]]></team_members_names><keywords_hr><![CDATA[vrijednosti, odluke,  kraj života, jedinice intenzivne skrbi, bioetika]]></keywords_hr><keywords_en><![CDATA[values, decisions, end of life, ICU, bioethics]]></keywords_en><summary_hr><![CDATA[ETHICUS studija provedena od 1999-2003 godine pokušala je dati odgovor o odlukama vezanim uz kraj života u jedinicama intenzivne skrbi u Europskim zemljama koje su bile dio studije. Hrvatska nije bila dijelom te studije niti su ikada istraživane vrijednosti i odluke vezane uz kraj života u jedinicama intenzivne skrbi u hrvatskom zdravstvenom sustavu. Tercijarna razina zdravstvene zaštite najviša je razina pružanje zdravstvenih usluga i razina na kojoj se rješavaju svi kompleksni slučajevi u Republici Hrvatskoj. Tako nije čest slučaj da se u intenzivnim jedinicama na toj razini zdravstvene zaštite donose složene odluke vezane za kraj života. Cilj je ovog projekta istražiti donošenje odluka vezanih uz kraj života u jedinicama intenzivne skrbi u bolnicama na tercijarnoj razini zdravstvene zaštite ( klinike, kliničke bolnice, klinički bolnički centri) u Republici Hrvatskoj te analizirati sustav vrijednosti liječnika i medicinskih sestara. Za potrebu postizanja ovih ciljeva oformljen je interdisciplinaran istraživački tim s iskustvom u sličnim istraživanjima. Kroz niz retrospektivnih i prospektivnih istraživanja kvantitativnog i kvalitativnog tipa pokušat će se dobiti podatke o donošenju odluka na kraju života u jedinicama intenzivne skrbi u Republici Hrvatskoj. Također će se kroz istraživanje na reprezentativnom uzroku stanovništva republike Hrvatske pokušati vidjeti koji su stavovi i vrijednosti vezani uz odluke na kraju života koji su dominanti među hrvatskom populacijom. Na kraju će se pokušati predložiti smjernice za donošenja odluka na kraju života u jedinicama intenzivne skrbi u Republici Hrvatskoj. ]]></summary_hr><summary_en><![CDATA[ETHICUS study (1999-2003) tried to give an answer on decisions related to the end of life in intensive care units in European countries that were part of the study. Croatia was not part of the study, nor was ever a research into values and decisions related to the end of life in intensive care units in the Croatian health system undertaken. The tertiary level of health care is the highest level of provision of health services and the level at which all complex cases in the Republic of Croatia as solved. So is often the case that in the intensive care units at this level of health care complex decisions about end of life are made. The aim of this project is to study decision-making related to the end of life in intensive care units in hospitals at the tertiary level health care (clinics, clinical hospitals, clinical hospital centres) in Croatia and analyse the value system of doctors and nurses. For the purpose of achieving these goals an interdisciplinary research team with experience in similar studies was created. Through a series of retrospective and prospective studies of quantitative and qualitative type will try to get information about the decision-making at the end of life in intensive care units in Croatia. A research on the representative sample of general population of the Republic Croatia will be performed in order to see what are the attitudes and values related to the decisions at the  end life that are dominant in the Croatian population. At the end will try to propose guidelines for decision-making at the end of life in intensive care units in Croatia. ]]></summary_en></project><project>
<id>4117</id><title_hr><![CDATA[Napredni senzorski sustavi za precizno navodnjavanje u krškom krajobrazu]]></title_hr><title_en><![CDATA[Advanced sensor systems for precision irrigation in karst landscape]]></title_en><user_id>18912</user_id><user_firstLast_name>Vedran Bilas</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2016-06</proposal_call><code>IP-2016-06-8379</code><acronim><![CDATA[SENSIRRIKA]]></acronim><duration>01.03.2017 - 28.02.2021</duration><status>Završio</status><financ_value>132.209,17 eur</financ_value><scie_area_hr>Tehničke znanosti, Biotehničke znanosti, </scie_area_hr><scie_area_en>Technological sciences, Biotechnical sciences, </scie_area_en><scie_field_hr>Elektrotehnika, Poljoprivreda, </scie_field_hr><scie_field_en>Electrical engineering, Agriculture, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id>12596, 19282, 19313, 19300, 19274, 19772, 25240, 27218, </team_members_id><team_members_names><![CDATA[Darko Vasić, Hrvoje Džapo, Monika Zovko, Davorin Ambruš, Dinko Oletić, Guido D&amp;#39;Urso, Marko Gazivoda, Martincic Emile, ]]></team_members_names><keywords_hr><![CDATA[senzori, niska cijena, niska potrošnja, tlo, biljka, voda, poljoprivreda, Mediteran, održivost]]></keywords_hr><keywords_en><![CDATA[sensors, low-cost, low power, soil, plant, water, agriculture, Mediterranean, sustainability]]></keywords_en><summary_hr><![CDATA[Krški krajobraz je poljoprivredni potencijal primorskih i otočnih područja, posebice za proizvodnju grožđa i maslina. Unatoč povoljnim klimatskim uvjetima, uslijed konfiguracije terena i strukture tla oborinske vode se ne zadržavaju u gornjim slojevima. Izvori vode u ovim krajevima su vrlo oskudni pa je njeno racionalno korištenje za navodnjavanje osobito važno. Precizno navodnjavanje primjenjuje potrebnu količinu vode na pravom mjestu i u pravo vrijeme čime raste kvaliteta plodova, smanjuju se troškovi i čuva okoliš. Za precizno navodnjavanje treba poznavati čimbenike tla, zraka i biljke te njihovu prostornu i vremensku promjenjivost. Opći cilj ovog projekta je doprinijeti održivosti poljoprivrede na mediteranskom kršu izloženom vodnom stresu. Vodna ravnoteža krškog tla se radi heterogenosti ne može odrediti komercijalnim senzorima te je prvi dio istraživanja usmjeren na razvoj naprednog elektromagnetskog senzora vlažnosti tla. Drugi dio istraživanja odnosi se na ekonomične senzore za motrenje vodne ravnoteže biljke koju treba određivati u gustom rasporedu radi prostorne varijabilnosti tla. Senzori koriste energiju iz okoline i iznimno su male potrošnje. Izvedeni su kao senzorski čvorovi bežične mreže čime se omogućuje fuzija senzorskih podataka cjelovite površine. Sustav je zasnovan na otvorenim komunikacijskim tehnologijama radi proširivosti i nadogradnje. Treći dio istraživanja odnosi se na agronomsku validaciju podataka demonstracijskog senzorskog sustava. U istraživanjima ćemo koristiti iskustva u navodnjavanju krških vinograda i maslinika, modeliranju elektromagnetskih svojstava tla i dizajnu naprednih elektromagnetskih senzora, primjeni bežičnih senzorskih mreža u poljoprivredi, projektiranju senzorskih sučelja s iznimno malom potrošnjom, razvoju napajanja energijom iz okoline te razvoju umreženih ugradbenih sustava. Razvijeno rješenje ćemo demonstrirati u stvarnim uvjetima i prenijeti znanja i iskustva na stručnu javnosti i industriju. ]]></summary_hr><summary_en><![CDATA[Karst landscapes can provide cultivated land in Adriatic coast and islands, especially for grapevine and olive trees. The area benefits from Mediterranean climate, but due to terrain configuration and soil structure, rain water percolates rapidly downward. As freshwater sources are very scarce, their rational use for irrigation is of the greatest importance. Precision irrigation (PI) refers to application of accurately assessed volume of water at right place and time to improve crops quality, reduce costs and preserve environment. Implementation of PI requires knowledge of soil, air and plant factors in space and time. The overall objective of this project is to contribute to sustainability of agriculture in karst Mediterranean landscape providing water stress information for PI. Due to coarse nature of karst soil, its water balance cannot be estimated by commercial root zone soil moisture sensors. First part of the research aims to development of an advanced electromagnetic (EM) karst soil moisture sensor. Second part of the research refers to cost-effective sensors for plant water balance monitoring that need to be densely deployed due to high within-field variability of soil. The sensors are ultra low power and use energy harvesting. They form wireless sensor network providing sensor data integration over field area. The network uses open communication technologies enabling scalability and upgrading. In third part of the research data from a field demonstrator are agronomically validated. In this project we will use our expertise in irrigation of karst; modelling of EM soil properties and design of advanced EM sensors; application of wireless sensor networks in agriculture; and design of ultra low power sensor interfaces, energy harvesting systems and networked embedded systems. We will demonstrate the developed system in field and transfer the knowledge and experiences to professional community and industry.]]></summary_en></project><project>
<id>4122</id><title_hr><![CDATA[Modernizacija urbanog života u Hrvatskoj kroz prizmu razvoja komunalne infrastrukture u 19. i 20. stoljeću]]></title_hr><title_en><![CDATA[The Modernisation of Urban Life in Croatia Considered through the Development of Municipal Infrastructure in the 19th and 20th Centuries]]></title_en><user_id>18907</user_id><user_firstLast_name>Marino Manin</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2016-06</proposal_call><code>IP-2016-06-2015</code><acronim><![CDATA[MOZIRA]]></acronim><duration>01.03.2017 - 31.07.2021</duration><status>Završio</status><financ_value>55.584,98 eur</financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Povijest, </scie_field_hr><scie_field_en>History, </scie_field_en><institution_hr><![CDATA[Hrvatski institut za povijest]]></institution_hr><institution_en><![CDATA[Croatian Institute of History]]></institution_en><team_members_id>19904, 20267, 6092, 20095, 20287, 1361, </team_members_id><team_members_names><![CDATA[Lidija Bencetić, Kristina Milković Šarić, Mario Bara, Tomislav  Anić, Goran Rajič, Hrvoje Čapo, ]]></team_members_names><keywords_hr><![CDATA[urbanizacija, modernizacija, komunalna infrastruktura, Zagreb, Hrvatska]]></keywords_hr><keywords_en><![CDATA[urbanization, modernization, municipal infrastructure, Zagreb, Croatia ]]></keywords_en><summary_hr><![CDATA[Pri obradi tematike predložene projektnim prijedlogom, polazište istraživača biti će demografske analize, rezultati gospodarskih povjesničara o procesu modernizacije u Hrvatskoj i raspoloživi podaci o komunalnoj infrastrukturi u gradovima (plinska i električna rasvjeta, uređenje ulica, razvoj vodovodne i kanalizacijske mreže, javnoga prometa, zbrinjavanje otpada i održavanje javnih površina, te telefonska mreža), a pristupiti će istraživanju arhivskih izvora u svrhu sagledavanja odnosa između razvoja komunalne infrastrukture i osuvremenjivanja načina života građana (od kretanja po gradu i komunikacije, preko promjena u načinu spremanja i čuvanja hrane, do osobne higijene i organizacije dana). U središtu istraživanja biti će grad Zagreb od njegovoga administrativnoga ujedinjenja 1850. godine do suvremenosti, a dobivene rezultate komparirati će se s infrastrukturnim rješenjima u drugim hrvatskim gradovima i to kako s regionalnim središtima (Rijeka, Split i Osijek), tako i s onima novonastalim zbog potreba gospodarstva (Borovo, Đurđenovac, Raša), a radna je hipoteza da su regionalne razlike u drugome planu, dok je daleko važniji tijek modernizacije i uvođenja inovacija. Istraživanje će donijeti više desetaka analitičkih radova za objavljivanje u znanstvenim časopisima u zemlji i inozemstvu, sudjelovanje na nizu znanstvenih skupova u zemlji i u inozemstvu, nekoliko znanstvenih monografija, kao i diseminaciju znanstvenih rezultata preko organizacije izložbe, radionica za studente i za građanstvo.]]></summary_hr><summary_en><![CDATA[In addressing the topics specified by the project proposal, the researchers will take the following as their starting points: demographic analysis, extensive work done by economic historians related to the process of modernisation in Croatia, and the available data on municipal infrastructure in cities (e.g., gas and electric lighting, street landscaping, the development of water supply and sewerage networks, public transport, waste disposal, the maintenance of public space, and the telephone network). Furthermore, the researchers will access archival sources, and attempt to establish and explain the relationship between the development of urban infrastructure and the impact it had on the modernisation of the everyday life of city dwellers (e.g., interurban mobility, communication, food storage and preparation, personal hygiene, daily routine, etc.). The research will focus on the City of Zagreb beginning with its administrative unification in 1850 and ending in the present time, while the results will be compared with the development of municipal infrastructure in other Croatian cities (both with important regional centres, such as Rijeka, Split and Osijek, and the newly built towns for special economic purposes, such as Borovo, Đurđenovac and Raša). The researchers’ working hypothesis is that regional disparities are not as important as modernisation itself and the introduction of innovations. The expected outcome of the research proposed will result in a dozen of analytical papers intended for publication in scientific journals both at home and abroad, participation in a series of both national and international scientific conferences, several scientific monographs, as well as the dissemination of scientific results through the organisation of exhibitions and workshops intended for both students and the general public.]]></summary_en></project><project>
<id>4123</id><title_hr><![CDATA[Hrvatski mrežni rječnik]]></title_hr><title_en><![CDATA[Croatian Web Dictionary]]></title_en><user_id>5199</user_id><user_firstLast_name>Lana Hudeček</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2016-06</proposal_call><code>IP-2016-06-2141</code><acronim><![CDATA[MREŽNIK]]></acronim><duration>01.03.2017 - 31.07.2021</duration><status>Završio</status><financ_value>78.298,76 eur</financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Filologija, </scie_field_hr><scie_field_en>Philology, </scie_field_en><institution_hr><![CDATA[Institut za hrvatski jezik]]></institution_hr><institution_en><![CDATA[Institute of Croatian Language]]></institution_en><team_members_id>11223, 5200, 5768, 19088, 19110, 19099, 19104, 19128, 19328, 7777, 2966, 25202, 25351, 26889, </team_members_id><team_members_names><![CDATA[Kristian Lewis, Milica Mihaljević, Barbara Kovačević, Ermina Ramadanović, Ivana Matas Ivanković, Joža Horvat, Domagoj Vidović, Goranka Blagus Bartolec, Dinka Pasini, Željko Jozić, Bruno Nahod, Josip Mihaljević, Daria Lazić, Maja Matijević, ]]></team_members_names><keywords_hr><![CDATA[mrežni rječnik, hrvatski rječnik, jednojezični rječnik,  hipertekstni rječnik, e-leksikografija, e- rječnik, rječnik utemeljen na korpusu]]></keywords_hr><keywords_en><![CDATA[web dictionary, Croatian dictionary, monolingual dictionary,  hipertext dictionary; e-leksicography, e- dictionary, corpus based dictionary]]></keywords_en><summary_hr><![CDATA[U okviru projekta Hrvatski mrežni rječnik (MREŽNIK) izradit će se slobodno dostupan, jednojezični, hipertekstni, jednostavno pretraživ mrežni rječnik hrvatskoga standardnoga jezika od 10 000 natuknica koji će omogućivati interakciju s korisnicima. Natuknice i pojedine riječi i izrazi u rječničkim člancima povezivat će se unakrižno i s natuknicama u bazama podataka koje će nastati u okviru ovoga projekta (baza jezičnih savjeta, baza veznika s opisom vezničkih skupina i njihove modifikacije, baza objašnjenja podrijetla frazema, baza etnika i ktetika). Uz osnovne, rječnik će uključivati i školske definicije (3000) i definicije za strance (1000). Rječnik će biti utemeljen na kopusu (Hrvatska mrežna riznica i Hrvatski mrežni korpus). Uz te će se izvore uzimati u obzir pri uspostavi definicija, donošenju primjera i značenja i svi drugi dostupni tiskani i mrežni izvori. Rječnik će se pisati u programu TLex, prilagođenu za potrebe projekta, a za uvid u korpus upotrijebit će se mrežni alat za pretragu korpusa SketchEngine. Nakon završetka leksikografske obradbe, podatci će biti izvezeni iz TLexa te izrađena mrežna aplikacija rječnika. U okviru projekta predviđena je: 1. izradba temeljnoga rječnika od 10 000 natuknica; 2. izradba popratnih baza i njihovo povezivanje s temeljnim rječnikom; 3. povezivanje temeljnoga rječnika s drugim mrežnim izvorima koji se trenutačno izrađuju u Institutu za hrvatski jezik i jezikoslovlje (bazom glagolskih  valencija, kolokacija, hrvatskoga strukovnog nazivlja, Repozitorijem hratskih metafora, mrežnim stranicama Bolje je hrvatski (bolje.hr)); 4. izradba odostražnoga rječnika.MREŽNIK je zamišljen kao dinamični rječnik koji nakon završetka projektnoga razdoblja otvara mogućnost daljnjega dopunjivanja.]]></summary_hr><summary_en><![CDATA[As a part of the MREŽNIK (Croatian Online Dictionary) project, the online monolingual dictionary of Standard Croatian language with ten thousand dictionary entries will be compiled. The dictionary will be free, easy to search, it will allow interaction with users and will contain hypertext links. The dictionary entries will contain links to certain other words, expressions and repositories (Linguistic Advice Repository, Conjunction Repository, etc.). The dictionary will be corpus based (Croatian Language Repository and Croatian Web Corpus), but other sources, online and printed, will be taken into account when looking for example sentences and writing entry definitions.The dictionary will be compiled using TLex, a professional software application for compiling dictionaries. SketchEngine will be used to search the corpus. After the completion of the dictionary entries, the data will be exported from TLex, and the Web application will be developed.   The project will:1. compile the basic dictionary consisting of ten thousand entries;2. develope additional repositories and connect them with the basic dictionary; 3. connect the basic dictionary with other online resources which are currently being developed at the Institute of Croatian Language and Linguistics: (The Verb Valence Repository, The Collocation Repository, The Croatian Special Field Terminology of Croatian repository (Struna), The Etymological Dictionary of Croatian, The Croatian Metaphor Repository, website bolje.hr;4. compile a reverse dictionary.MREŽNIK is conceived as a dynamic dictionary, the development of which will not end at the end of the project.]]></summary_en></project><project>
<id>4125</id><title_hr><![CDATA[Održivost javnih financija na putu u monetarnu uniju]]></title_hr><title_en><![CDATA[Public finance sustainability on the path to the monetary union]]></title_en><user_id>3265</user_id><user_firstLast_name>Hrvoje Šimović</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2016-06</proposal_call><code>IP-2016-06-4609</code><acronim><![CDATA[PuFiSuMU]]></acronim><duration>12.12.2016 - 12.03.2020</duration><status>Završio</status><financ_value>25.152,96 eur</financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Ekonomija, </scie_field_hr><scie_field_en>Economy, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Ekonomski fakultet u Zagrebu]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Economics and Business]]></institution_en><team_members_id>12739, 4043, 3555, 5884, 22597, 26392, </team_members_id><team_members_names><![CDATA[Paško Burnać, Mirna Dumičić, Milan  Deskar-Škrbić, Tomislav Ćorić, Antonija Buljan, Marija  Davidović, ]]></team_members_names><keywords_hr><![CDATA[Fiskalna održivost, monetarna unija, javni dug, fiskalni multiplikatori, narativni pristup, mala i otvorena ekonomija, model opće ravnoteže, Hrvatska]]></keywords_hr><keywords_en><![CDATA[Fiscal sustainability, monetary union, public debt, fiscal multipliers, narrative approach, small and open economy, general equilibrium models, Croati]]></keywords_en><summary_hr><![CDATA[U posljednjem desetljeću Hrvatska je prošla dinamičan ekonomski i politički put koji je bio obilježen sa šest godina recesije i ulaskom u EU. Navedeno razdoblje karakterizirala je neusklađenost ekonomskih politika i nedostatak konzistentne fiskalne politike uzrokovane političkom nestabilnosti (3 koalicijske Vlade, 4 premijera, 5 ministra financija), ali i sustavne nespremnosti Vlada na provođenje suštinske fiskalne konsolidacije. Diskrecijske mjere u najvećoj su se mjeri svodile na povećanje porezne presije radi smanjivanja deficita, dok se na rashodnoj strani provodila tzv. politika nečinjenja što je rezultiralo izostankom strukturnih reformi. Takva politika rezultirala je eksplozijom javnog duga (s 36% na 85% BDP-a od 2008-15). U međuvremenu je snižen kreditni rejting na špekulativnu razinu te je aktiviran postupak prekomjernog deficita (EDP) i postupak prekomjernih makroekonomskih neravnoteža (MIP). U uvjetima slabog rasta (oko 2%) i fiskalne neodrživosti (kamate iznose oko 3,5% BDP-a), nositeljima ekonomske politike posao dodatno otežava činjenica da Hrvatska u svojoj europskoj perspektivi ima obavezu uvođenja Eura.Osnovi cilj predloženog projekta je analiza i evaluacija održivosti javnih financija u Hrvatskoj te projekcija dinamike javnog duga s ciljem postizanja potrebnih kriterija konvergencije i uvođenja Eura. Očekivani rezultati istraživanja dali bi cjelovitu sliku mogućnosti fiskalne i monetarne politike da u srednjem roku osvare preduvjete za ulazak Hrvatske u monetarnu uniju. Kao krajnji cilj trebalo bi se utvrditi optimalno razdoblje i tranzicijski trošak ulaska i uvođenje Eura, kao i sve ekonomske pretpostavke za ostvarivanje predloženog scenarija.]]></summary_hr><summary_en><![CDATA[In the last decade Croatia has experienced a dynamic economic and political path during which Croatia struggled with six years of recession and joined the EU. The observed period was characterized by uncoordinated economic policies and the lack of consistent fiscal policy partially due to the political instability (3 coalition governments, 4 Prime Ministers, 5 Ministers of Finance), but also because of the lack of government’s efforts to implement substantial fiscal consolidation. Discretionary measures were mainly conducted by increasing taxes in order to reduce the budget deficit, while government spending was led by the “policy of doing nothing” which resulted with the absence of structural reforms. Aforementioned policies resulted in public debt explosion (36% to 85% GDP in 2008-15). In the meanwhile, credit-rating was downgraded to the speculative level, and the EC activated Excessive deficit procedure (EDP) and Macroeconomic imbalances procedure (MIP). Need for fiscal consolidation in the period of slow economic growth (around 2%) and fiscal unsustainability (interest expenses amount to 3.5% of GDP) are even more challenging having in mind the fact that economic and political EU future includes (obligatory) adoption of the Euro. The overall goal of the proposed project is to analyse and evaluate Croatia’s public finance sustainability and to estimate public debt dynamics in order to fulfil convergence criteria and adopt the Euro. Expected results of this research should provide an overview of the possibilities of fiscal and monetary policies in the mid-term to create the preconditions for the Croatian accession to the EMU. The ultimate goal is to determine the target date for Croatia&#39;s accession, evaluate transition cost of adopting the Euro and to determine all economic requirements in order to achieve that goal. ]]></summary_en></project><project>
<id>4132</id><title_hr><![CDATA[Višegodišnje i dekadne oscilacije Jadranskog mora: opažanja, modeliranje  i posljedice]]></title_hr><title_en><![CDATA[The Adriatic interannual to decadal oscillations: observations, modelling and consequences]]></title_en><user_id>195</user_id><user_firstLast_name>Ivica Vilibić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2016-06</proposal_call><code>IP-2016-06-1955</code><acronim><![CDATA[ADIOS]]></acronim><duration>20.03.2017 - 19.03.2021</duration><status>Završio</status><financ_value>130.400,16 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Geofizika, </scie_field_hr><scie_field_en>Geophysics, </scie_field_en><institution_hr><![CDATA[Institut za oceanografiju i ribarstvo]]></institution_hr><institution_en><![CDATA[Institute of Oceanography and Fisheries]]></institution_en><team_members_id>357, 19180, 19158, 5979, 17732, 17848, 19409, 19884, 25204, </team_members_id><team_members_names><![CDATA[Ivica Janeković, Clea Denamiel, Manuel Bensi, Darko Koracin, Natalija Dunić, Slavko Radilović, Vedrana Kovačević, Samuel Somot, Petra Zemunik, ]]></team_members_names><keywords_hr><![CDATA[Jadransko more, višegodišnje i dekadske oscilacije, stvaranje guste vode, BIOS, združeno klimatsko modeliranje atmosfere i mora]]></keywords_hr><keywords_en><![CDATA[Adriatic Sea, interannual and decadal oscillations, dense water formation, BIOS regimes, coupled atmosphere/ocean climate modelling]]></keywords_en><summary_hr><![CDATA[Glavni cilj projekta Adios je istražiti i kvantificirati procese koji pogone međugodišnje i desetljetne termohaline varijacije u jadransko-jonskom bazenu. Cilj će se postići (i) dokumentiranjem međugodišnje i desetljetne varijabilnosti analizom dugoročnih oceanografskih mjerenja i postojećih klimatskih modela, (ii) istraživanjem kratkoročnih i dugogodišnjih procesa koji pokreću jadransko-jonsku termohalinu cirkulaciju, u prvom redu stvaranje guste vode u Jadranu i BIOS-a (Bimodalna jadransko-jonska oscilacija), i (iii) procjenom prošle i buduće jadranske klime i varijabilnosti primjenom jadranskog združenog (atmosfera-more) klimatskog modela visoke razlučivosti. Iako se odavno zna da je međugodišnja i desetljetna termohalina promjenjivost dominantna u Jadranu, odgovarajuća teorija (BIOS) razvijena je tek nedavno, te još uvijek nije ispravno reproducirana od strane oceanskih numeričkih modela. Stoga će se u okviru ADIOS projekta postaviti i pokrenuti ugniježđeni združeni klimatski model visoke rezolucije u području Jadrana. Nakon verifikacije nad mjerenjima, model će se primijeniti na buduću klimu koristeći nekoliko IPCC scenarija. Takav pristup omogućit će preciznu procjenu budućih klimatskih promjena na Jadranu, uključujući i višegodišnju i desetljetnu varijabilnost i regulirajuće procese, što će biti temelj za procjenu klimatskih rizika na nacionalnoj i regionalnoj razini. Značajan projektni napor će se posvetiti nastavku mjerenja na Palagruškom oceanografskom profilu, najdužem sezonski uzorkovanom oceanografskom transektu na Sredozemlju u trajanju od oko 60 godina, ali vrlo rijetko uzorkovanom nakon 2013. godine. ADIOS projekt će imati snažnu međunarodnu komponentu koja uključuje priznate oceanografske institute (OGS, CNRS-GAME), te njihove istraživače aktivno uključene na predviđena projektna istraživanja, što će rezultirati povećanjem kapaciteta, umreženosti i učinkovitosti hrvatske oceanografske i klimatske zajednice.]]></summary_hr><summary_en><![CDATA[The major objective of the ADIOS project is to investigate and to quantify processes driving interannual to decadal thermohaline variations in the Adriatic-Ionian basin. This objective will be achieved by (i) documenting interannual to decadal variability from long-term oceanographic series and existing climate models, (ii) investigating short- and long-time processes that drive the Adriatic-Ionian thermohaline circulation, primarily the Adriatic dense water formation and the BiOS (Adriatic-Ionian Bimodal Oscillating System), and (iii) assessing past and future Adriatic climate and variability from the Adriatic-adopted high-resolution atmosphere/ocean climate model runs. Although interannual to decadal thermohaline variability is known to be dominant in the Adriatic, the respective theory (cf. BIOS) has been developed very recently and is still not properly reproduced and verified by ocean numerical models. To tackle this, the Adriatic climate run will be setup and executed through nesting of state-of-the-art high-resolution atmospheric/ocean models into the Mediterranean runs. Once validated for a 30 year hindcast time period, the Adriatic model will be used in forecast mode for several IPCC scenarios. Such an approach will allow for better assessment of future climate changes in the Adriatic, including interannual to decadal variability and governing processes. These simulations will be a base for an upgrade in climate hazard assessment on national and basin levels. A significant project effort will be dedicated to continuation of the Palagruža Sill oceanographic transect, the longest seasonally-sampled transect in the Mediterranean, lasting over 60 years but very sparsely sampled since 2013. The project will have a strong international component, incorporating recognized institutes (OGS, CNRS-GAME) and their researchers to the ADIOS research and therefore increasing capacities, networks and efficiency of the Croatian oceanographic and climate communities.]]></summary_en></project><project>
<id>4133</id><title_hr><![CDATA[Struktura, funkcija i evolucija proteina Nme6/Nm23-H6]]></title_hr><title_en><![CDATA[Structure, Function and Evolution of Nme6/Nm23-H6 protein]]></title_en><user_id>1107</user_id><user_firstLast_name>Maja Herak Bosnar</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2016-06</proposal_call><code>IP-2016-06-4021</code><acronim><![CDATA[Nemo6]]></acronim><duration>01.03.2017 - 30.11.2021</duration><status>Završio</status><financ_value>131.395,58 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Biologija, </scie_field_hr><scie_field_en>Biology, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>1322, 649, 1426, 22818, 25045, </team_members_id><team_members_names><![CDATA[Anđela Horvat, Neda Slade, Nikolina Škrobot Vidaček, Martina Radić, Bastien Proust, ]]></team_members_names><keywords_hr><![CDATA[Nm23, Nme, NDPK, NDK, supresor metastaziranja]]></keywords_hr><keywords_en><![CDATA[Nm23, Nme, NDPK, NDK, metastasis supressor]]></keywords_en><summary_hr><![CDATA[Nukleozid difosfatske kinaze (Nme/Nm23/NDPK) čine obitelj evolucijski očuvanih enzima, ključnih za odvijanje mnogo važnih bioloških procesa no njihova biokemijska funkcija nije još sasvim razjašnjena. Obitelj se sastoji od 10 članova podijeljenih u dvije skupine. Članovi Grupe I dosad su se intenzivno istraživali, posebice Nme1 u kontekstu formiranja metastaza te Nme2 koji je uključen u bolesti srca. Članovi Grupe I u ljudi pokazuju visok stupanj homologije unutar grupe kao i u usporedbi s ortolozima kod ostalih Metazoa. Posjeduju aktivnost NDPK ukoliko zauzmu oblik heksamera. Članovi Grupe II imaju znatno manji stupanj međusobne homologije te nemaju aktivnost NDPK, osim potencijalno protein Nme6, dok im multimerna struktura nije još utvrđena. Članovi Grupe II pojavili su se ranije tijekom evolucije, posebice Nme5, Nme6 i Nme7. O članovima Grupe II vrlo se malo zna, ali naši rezultati na genu/proteinu Nme6 kod spužve,Nme6Sd, upućuju na činjenicu da spužvin protein ima drugačije stanične funkcije nego njegov ljudski ortolog. Spužve smatramo živim fosilima i općenito se prihvaća teorija da se njihov genom i proteom nije znatno mijenjao posljednjih 500 milijuna godina te je sačuvao karakteristike genoma i proteoma pretka svih Metazoa. Predloženi projekt nastavlja se na naša prijašnja istraživanja na proteinima obitelji Nme kod ljudi i spužve, a usmjerit će se na rješavanje strukture te biokemijske i biološke funkcije ljudskog Nme6 i njegove promjene tijekom evolucije. U tu svrhu upotrijebit ćemo niz biokemijskih metoda koje ćemo poduprijeti metodama molekularne biologije i napredne konfokalne mikroskopije. Uvjereni smo da će naše istraživanje na Nme6 uvelike doprinijeti općem poznavanju obitelji gena/proteina te dati uvid u uloge njenih članova u glavnim bolestima današnjice. ]]></summary_hr><summary_en><![CDATA[Nucleoside-diphosphate kinases (Nme/Nm23/NDPK) are a family of evolutionary conserved enzymes involved in many crucial biological processes, but their biochemical functions have not yet been fully elucidated. The family consists of ten members divided in two groups of which the Group I has been extensively studied, especially the Nme1 in the context of metastasis formation and the Nme2 which appears to be involved in cardiac diseases. The Group I members in humans are generally highly homologous among themselves and in comparison to their orthologues in other Metazoans. They all possess the NDPK activity in their hexameric form. The Group II members display a lower level of mutual homology and, with a possible exception of Nme6, do not possess the NDPK activity, while their multimeric structure has not yet been revealed. The Group II members are evolutionary older, especially the Nme5, Nme6 and Nme7. Little is known about the Group II Nme members but our recent findings on Nme6Sd, the Nme6 gene/protein from marine sponge Suberites domuncula suggest that Nme6Sd has different cellular functions from its human orthologue. Sponges are regarded to be living fossils, and it is widely accepted that their genome and proteome structure did not change much in the last 500 million years. Therefore, they have probably preserved the genome and proteome structure of the common ancestor of all Metazoans. Building upon our previous work on the human and sponge Nme family of proteins, the proposed project will focus on resolving the structure and biochemical and biological functions of the human Nme6 and its changes during evolution. For this purpose we will employ a range of biochemical methods and combine them with modern molecular biology methods supported by advanced confocal microscopy techniques. We are confident that our research on the Nme6 will largely contribute to the knowledge on this gene/protein family in general and the roles of its members in major human diseases.]]></summary_en></project><project>
<id>4149</id><title_hr><![CDATA[Udobnost i antimikrobna svojstva tekstila i obuće]]></title_hr><title_en><![CDATA[Comfort and antimicrobial properties of textiles and footwear]]></title_en><user_id>4089</user_id><user_firstLast_name>Zenun Skenderi</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2016-06</proposal_call><code>IP-2016-06-5278</code><acronim><![CDATA[ComforMicrobTexFoot]]></acronim><duration>01.03.2017 - 31.12.2021</duration><status>Završio</status><financ_value>96.104,59 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Tekstilna tehnologija, </scie_field_hr><scie_field_en>Textile technology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Tekstilno-tehnološki fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Textile Technology]]></institution_en><team_members_id>4648, 4244, 19373, 405, 19372, 4097, 6964, 19362, 19919, 7338, 6722, 22458, 22481, 21364, 4173, 28975, 29056, </team_members_id><team_members_names><![CDATA[Zlatko Vrljičak, Alka Mihelić-Bogdanić, Jadranka Akalović, Tomislav Ivanković, Franka Žuvela Bošnjak, Dragana Kopitar, Antoneta Tomljenović, Beti Rogina-Car, Željka Pavlović, Lubos Hes, Sanja Ercegović Ražić, Jelena Peran, Tariq  Mansoor, Ivan Kraljević, Ivana Špelić, Juro Živičnjak, Suzana Mihanović, ]]></team_members_names><keywords_hr><![CDATA[Udobnost, pletivo, celuloza, nekonvencionalna pređa, bakterije, zaštita, obuća, koža, kompoziti]]></keywords_hr><keywords_en><![CDATA[Comfort, knitted fabric, nonconventional yarn, cellulose, bakterium, protection, footwear, leather, composite]]></keywords_en><summary_hr><![CDATA[Udobnost i antibakterijska svojstva tekstila za izradu odjeće koja priliježe uz kožu i obuće, za određenu vrstu i razinu aktivnosti te uvjete okoline, u najvećoj su mjeri određeni vrstom sirovine, strukturom i svojstvima tekstilnog plošnog proizvoda/kože, vrstom dorade te formom gotovog proizvoda odjeće/obuće koji se nosi. Kako bi se dobile nove spoznaje i dublje rasvijetlile povezanosti udobnosti i antibakterijskih svojtava sa svojstvima proizvoda, od sirovine, pređe, sirovog te sirovog i antibakterijski obrađeno pletiva, proizvesti će se triko predene nekonvencionalne pređe (rotorska i aerodinamička) iz umjetnih celuloznih vlakana, SIRO pređa iz viskoznih vlakana i prstenasta pređa iz pamuka poznatih karakteristika. Finoća svih predenih pređa je iz 10 tex × 2 (Nm100/2), dok je finoća SIRO pređe 10 tex × 2 (Nm100/2). Plesti će se pletiva u različitim vezovima. U pletiva za čarape dodavati će se PA multifilamentne pređe. Izraditi će se uzorci gotove kože (goveđa i teleća) za unutarnje dijelove gornjišta radne i zaštitne obuće, koji će biti obrađeni različitim vrstama štavila. Analizirati će se 3 uzorka, natur crust, doštavljeni crust uz istovremenu obradu antimikrobnim sredstvima te bojadisani crust uz nadoštavu i antimikrobnu obradu. Na svim uzorcima, pletiva te na uzorcima koža, odrediti će se objektivni parametri termofiziološke udobnosti (otpor prolazu topline i otpor prolazu vodene pare). Antimikrobna aktivnost svih uzoraka pletiva (antimikrobno tretirana) i koža, odrediti će se prema 3 vrste bakterija (A. baumannii, S. aureus i E. coli) koje se mogu naći u normalnoj fiziološkoj flori kože čovjeka, a koje mogu biti oportunistički patogeni. Odrediti će se i termofiziološka udobnost čarapa te radno zaštitne obuće proizvedene u domaćim tvornicama na Termalnom stopalu. Na jednom broju uzoraka kože (kromne i sintetske štave) provesti će se Komet test.]]></summary_hr><summary_en><![CDATA[Comfort and antibacterial properties of fabrics for making clothing worn next to the skin and footwear, for particular type and level of activity as well as environmental conditions are mostly determined by the type of raw material, structure and properties of fabric/leather, finishing process and shape of the final product, garment/footwear to be worn. In order to obtain new findings about comfort and antibacterial properties of products from raw materials, yarns, grey and grey and antibacterially treated knitted fabric, fabric will be made from conventional yarn (rotor-spun and aerodynamic yarn) made from man-made cellulosic fibres, SIRO yarns from viscose fibres and ring-spun yarn from cotton with known properties. The fineness of all spun yarns is 10 tex x 2 (Nm 100/2), while the count of SIRO yarn is 10 tex x 2 (Nm 100/2). Fabrics will be knitted in different constructions. PA multifilament yarns will be added into knitted fabrics for making hosiery.Samples of finished leather (cow and calfskin leather) for inner parts of the upper of working and protective footwear will be prepared. They will be treated with different types of tanning agents. Three samples will be prepared, nature crust, post-tanned crust with the simultaneous treatment with antimicrobial agents and dyed crust with post-tanning and antimicrobial treatment. For all samples of knitted fabrics and leathers objective parameters of thermophysiological comfort will be determined. Antimicrobial activity of all samples of knitted fabric (antimicrobially treated) and leather will be determined according 3 types of bacteria (A. baumannii, S. aureus and E. coli) that can be found in the normal physiological skin flora of man which can be opportunistic pathogens. Thermophysiological comfort of hosiery and working and protective footwear manufactured at local factories will be determined on thermal foot. The comet test will be performed for a number of leather samples (chrome- and synthetic tanned).  ]]></summary_en></project><project>
<id>4158</id><title_hr><![CDATA[Lipidi hrane, spol i dob u patogenezi metaboličkog sindroma]]></title_hr><title_en><![CDATA[Dietary lipids, sex and age in pathogenesis of metabolic syndrome ]]></title_en><user_id>12663</user_id><user_firstLast_name>Kristina Starčević</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2016-06</proposal_call><code>IP-2016-06-3163</code><acronim><![CDATA[DietMetSyn]]></acronim><duration>01.12.2017 - 30.11.2021</duration><status>Završio</status><financ_value>132.284,82 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Veterinarska medicina, </scie_field_hr><scie_field_en>Veterinary medicine, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Veterinarski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Veterinary Medicine]]></institution_en><team_members_id>5392, 12628, 1195, 12946, 11258, 13016, 4742, 19404, 13262, 19649, 19446, 19753, 19807, 19676, 19715, 20212, 12528, 19731, 25364, 857312, </team_members_id><team_members_names><![CDATA[Tomislav Mašek, Luka Krstulović, Ivan - Conrado Šoštarić - Zuckermann, Diana Brozić, Silvijo Vince, Maja Maurić, Krešimir Severin, Nada Kučer, Petar Džaja, Gordana Nedeljković, Dražen Vnuk, Andrija Musulin, Jasna Dogan, Žarko Ćirić, Ivana Jarak, Snježana Dragojević, Miroslav Bajić, Rui  de Albuquerque Carvalho, Petra Roškarić, Valentina Percan, ]]></team_members_names><keywords_hr><![CDATA[Lipidi, metabolički sindrom, hrana, miRNA, kronična upala, rezistencija na inzulin]]></keywords_hr><keywords_en><![CDATA[Lipids, metabolic syndrome, food, miRNA, cronic inflammation, insulin resistence]]></keywords_en><summary_hr><![CDATA[Poremećaj metabolizma lipida ključna je komponenta u razvoju metaboličkog sindroma pa je i prevalencija metaboličkog sindroma povezana sa stupnjem pretilosti. Stoga, promjene u sastavu hrane mogu biti važna strategija za prevenciju metaboličkog sindroma i posljedičnih bolesti.Pretilost nastaje tijekom dugotrajne pozitivne energetske ravnoteže koja potiče proupalni odgovor. To uzrokuje kroničnu upalu i pojačani dotok lipida iz masnog tkiva u jetru, mišićno tkivo i gušteraču što rezultira s glukotoksičnosti i lipotoksičnosti. Kronična upala i rezistencija na inzulin danas su prepoznati kao bitni čimbenici kod mnogih bolesti kao što su dijabetes tipa 2, kardiovaskularne bolesti, Alzheimerove bolesti i tumora.Za postizanje ciljeva projekta istražit ćemo nekoliko interakcija važnih za patogenezu metaboličkog sindroma: A) utjecaj n3/n6 omjera lipida hrane i dodavanja DHA kao prevencije metaboličkog sindroma, B) utjecaj n3/n6 omjera lipida hrane i dodavanja DHA kao moguće terapije metaboličkog sindroma, C) prijenos sklonosti razvitku metaboličkog sindroma i prekomjerne tjelesne mase s roditelja na potomstvo kao i utjecaj prehrane potomstva na težinu poremetnji prije i nakon spolne zrelosti, D) interakciju između dobi i metaboličkog sindroma i E) metabolizam lipida u tumorskom tkivu i tumorske markere lipidnog porijekla kao moguću vezu između pretilosti, metaboličkog sindroma, kronične upale i tumora.Naposlijetku, podaci iz cijelog projekta rezultirat će integracijom stečenih znanja iz svih pokusa i boljem razumijevanju složenosti patogeneze metaboličkog sindroma. Integrativni pristup omogućit će nove pristupe prevenciji i liječenju metaboličkog sindroma putem modifikacije prehrane kao i bolje razumijevanje veze između kronične upale izazvane pretilošću i tumora.]]></summary_hr><summary_en><![CDATA[Dysfunction of lipid metabolism is a key component in the development of metabolic syndrome and the prevalence of metabolic syndrome is strongly associated with the severity of obesity. Therefore, dietary intervention could be important strategy for the prevention of metabolic syndrome and associated diseases.Obesity arises from a sustained positive energy balance which triggers a pro-inflammatory response. These disturbances culminate in impaired insulin signaling, dysregulated glucose homeostasis and consequent development of insulin resistance. Chronic inflammation and insulin resistance are now recognized as contributing factors to many modern diseases such as insulin non dependent diabetes mellitus, cardiovascular diseases, Alzheimer disease and cancer. To achieve project objectives we will investigate several interactions that take place in metabolic syndrome pathogenesis: A) Influence of dietary n6/n3 ratio and DHA as a preventive mechanism on the severity of metabolic syndrome, B) Influence of dietary n6/n3 ratio and DHA on therapy of induced metabolic syndrome, C) Parental transmission of predisposition to obesity-related disorders to their offspring and influence of offspring diet on severity of metabolic disorders before and after sexual maturity, D) Interaction between age and metabolic syndrome and E) Cancer lipid metabolism and cancer markers of lipid origin as well as possible link between obesity, metabolic syndrome, low grade chronic inflammation and cancer.Finally, data from the whole project will result in the integration of gained knowledge from all experiments and in better understanding of complex pathogenesis of metabolic syndrome. Integrative approach will allow us to suggest new approaches to dietary prevention and therapy of metabolic syndrome and to better understand underlying link between obesity related chronic inflammation and cancer.]]></summary_en></project><project>
<id>4165</id><title_hr><![CDATA[Prevalencija i molekularna epidemiologija emergentnih i re-emergentnih neuroinvazivnih arbovirusnih infekcija na području Hrvatske]]></title_hr><title_en><![CDATA[Prevalence and molecular epidemiology of emerging and re-emerging neuroinvasive arboviral infections in Croatia]]></title_en><user_id>19086</user_id><user_firstLast_name>Tatjana Vilibić Čavlek</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2016-06</proposal_call><code>IP-2016-06-7456</code><acronim><![CDATA[CRONEUROARBO]]></acronim><duration>01.03.2017 - 28.02.2021</duration><status>Završio</status><financ_value>128.526,11 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo, Prirodne znanosti, </scie_area_hr><scie_area_en>Biomedicine and health sciences, Natural sciences, </scie_area_en><scie_field_hr>Javno zdravstvo i zdravstvena zaštita, Biologija, Kliničke medicinske znanosti, Veterinarska medicina, </scie_field_hr><scie_field_en>Public health and health services, Biology, Clinical sciences, Veterinary medicine, </scie_field_en><institution_hr><![CDATA[Hrvatski zavod za javno zdravstvo, Zagreb]]></institution_hr><institution_en><![CDATA[Croatian National Institute of Public Health, Zagreb]]></institution_en><team_members_id>19507, 2676, 19827, 19511, 19394, 19533, 4211, 19546, 4371, 19530, 7738, 3103, 2964, 19517, 19803, 2546, 2599, 19651, 409, 25186, 25187, 21453, 25253, 3892, 25260, </team_members_id><team_members_names><![CDATA[Ljiljana Perić, Nenad Pandak, Tanja Potočnik-Hunjadi, Andrea Babić-Erceg, Irena Tabain, Mario  Sviben, Maja Bogdanić, Tatjana Avšič-Županc, Ljubo Barbić, Vladimir Stevanović, Josip Madić, Vladimir Savić, Andreja Jungić, Ana Klobučar, Krunoslav Capak, Lorena Jemeršić, Jelena Prpić, Bernard Kaić, Branko Kolarić, Elizabeta Dvorski, Marina Baličević, Marija Santini, Dario  Sabadi, Marko Vucelja, Marko Boljfetić Boljfetić, ]]></team_members_names><keywords_hr><![CDATA[Arbovirusi, neuroinvazivne infekcije, prevalencija, molekularna epidemiologija, Hrvatska]]></keywords_hr><keywords_en><![CDATA[Arboviruses, neuroinvasive diseases, prevalence, molecular epidemiology, Croatia]]></keywords_en><summary_hr><![CDATA[Emergentne arbovirusne infekcije značajan su uzrok morbiditeta i mortaliteta. Iako većina infekcija prolazi asimptomatski, u nekih se bolesnika arbovirusne infekcije očituju teškom kliničkom slikom neuroinvazivne bolesti. Dok je uloga virusa krpeljnog encefalitisa (KEV), virusa Zapadnog Nila (VZN) i Toscana virusa (TOSV) u etiologiji neuroinvazivnih bolesti poznata, uloga Usutu virusa (USUV), Zika virusa (ZIKV), dengue virusa (DENV) i chikungunya virusa (CHIKV) još uvijek nije dovoljno istražena. U Hrvatskoj se godišnje prijavljuje prosječno 200 slučajeva seroznih meningitisa/encefalitisa od kojih u 80-90% nije dokazana etiologija. To se posebno odnosi na emergentne viruse koji nisu uključeni u rutinsko dijagnostičko testiranje. Isto tako, nisu dovoljno istražene kliničke i epidemiološke značajke arbovirusnih infekcija. Određivanje seroprevalencije u ljudi i životinja te prisutnosti virusa u vektorima vrlo su dobri pokazatelj cirkulacije i proširenosti arbovirusnih infekcija na nekom području. Ovo interdisciplinarno (&#39;&#39;Jedno zdravlje&#39;&#39;) istraživanje uključit će bolesnike s kliničkom slikom neuroinvazivne bolesti s područja kontinentalne Hrvatske, oboljele u sezoni prijenosa arbovirusa. Istražit će se učestalost neuroinvazivnih arbovirusa: KEV, VZN, USUV, TOSV, DEVN, CHIKV, ZIKV određivanjem virusne RNA u likvoru/urinu te protutijela u serumu, definirati kliničke i molekularno epidemiološke značajke arbovirusnih infekcija. Nadalje, definirat će se rasprostranjenost arbovirusnih infekcija određivanjem seroprevalencije u asimptomatskih osoba i sentinel životinja (konji, domaća perad) te prisutnost virusa u vektorima (komaraci/krpelji).Moguća detekcija novih arbovirusa omogućit će razjašnjenje etiologije u bolesnika oboljelih od neuroinvazivnih bolesti. Definiranje molekularno-epidemioloških značajki doprinijet će boljem razumijevanju epidemiologije arbovirusnih infekcija kao i unaprjeđenju ciljanih javnozdravstvenih mjera prevencije i suzbijanja arbovirusnih bolesti. ]]></summary_hr><summary_en><![CDATA[Emerging and re-emerging arboviral diseases are important cause of morbidity and mortality. Although majority infections are asymptomatic, some patients develop a severe neuroinvasive disease. While the role of the tick-borne encephalitis virus (TBEV), West Nile virus (WNV) and Toscana virus (TOSV) in the etiology of neuroinvasive diseases is well-known, the role of Usutu virus (USUV), Zika virus (ZIKV), dengue virus (DENV) and chikungunya virus (CHIKV) is rather unknown. About 200 cases of aseptic meningitis/encephalitis are reported annually in Croatia, of which in 80-90% etiology has remained unknown. This is particularly important for emerging viruses which are not included in the routine diagnostic testing. Moreover, the clinical and epidemiological characteristics of arboviral infections are not fully investigated. Seroprevalence determination in humans and animals, as well as detection of viruses in vectors are good indicators of circulation and geographical distribution of arboviruses in a certain area. This prospective interdisciplinary (&#39;&#39;One health&#39;&#39;) study will include patients with clinical symptoms of neuroinvasive disease from the continental Croatian regions who developed symptoms during the arbovirus transmission season. The prevalence of neuroinvasive arboviruses (TBEV, WNV, USUV, TOSV, DENV, CHIKV, ZIKV) will be determined by detection of viral RNA in the cerebrospinal fluid/urine and detection of antibodies in serum. Clinical characteristics and molecular epidemiology will be defined. Additionally, the geographical distribution of arboviral infections will be analyzed by determination of seroprevalence in asymptomatic persons and sentinel animals as well as detection of viruses in vectors.Possible detection of new arboviruses will clarify the etiology in patients with neuroinvasive diseases. Molecular epidemiology data will provide better understanding of epidemiology of arboviral infections as well as improving the public health measures.]]></summary_en></project><project>
<id>4167</id><title_hr><![CDATA[Interakcija renin-angiotenzinskog i adrenergičkog sustava u aktivaciji endotela uzrokovanoj oksidativnim stresom]]></title_hr><title_en><![CDATA[Interaction of Renin-Angiotensin and Adrenergic System in Oxidative Stress Induced Endothelial Activation]]></title_en><user_id>487</user_id><user_firstLast_name>Ana Stupin (rođ. Čavka)</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2016-06</proposal_call><code>IP-2016-06-8744</code><acronim><![CDATA[RAS-AdrenOX]]></acronim><duration>03.04.2017 - 02.10.2021</duration><status>Završio</status><financ_value>132.682,33 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište Josipa Jurja Strossmayera u Osijeku, Medicinski fakultet Osijek]]></institution_hr><institution_en><![CDATA[Josip Juraj Strossmayer University of Osijek, Faculty of Medicine]]></institution_en><team_members_id>488, 548, 477, 594, 482, 19414, 20340, 722, 732, 6307, </team_members_id><team_members_names><![CDATA[Martina Mihalj, IVANA JUKIĆ (rođ.GRIZELJ), Ines Drenjančević, Anita Ćosić, Zrinka Mihaljević, Marko Stupin, Ines Mrakovčić-Šutić, Kristina Selthofer-Relatić, Aleksandar Kibel, Vatroslav Šerić, ]]></team_members_names><keywords_hr><![CDATA[renin-angiotenzinski sustav, adrenergički sustav, oksidativni stres, mikrocirkulacija, leukociti, upala]]></keywords_hr><keywords_en><![CDATA[Renin-Angiotensin System, Adrenergic System, Oxidative Stress, Microcirulation, Leukocyte, Inflammation ]]></keywords_en><summary_hr><![CDATA[Rezultati nedavnih studija pokazali su kako inhibicija renin-angiotenzinskog sustava (RAS) i niska koncentracija angiotenzina II (ANG II) potaknuta visokim unosom kuhinjske soli uzrokuje oštećenje endotelne funkcije i mikrovaskularne reaktivnosti u zdravih pojedinaca (bez promjena arterijskoga tlaka) vjerojatno povišenjem razine oksidativnog stresa. Ipak, još uvijek nije istraženo na koji način inhibicija RAS-a djeluje na aktivnost adrenergičkog sustava, te mogu li te promjene doprinijeti oštećenju endotelne funkcije povišenjem oksidativnog stresa. Također, smatra se kako inhibicija RAS-a, povećanim unosom kuhinjske soli, može djelovati kao okidač za ravoj upalnog procesa i endotelno-leukocitnu aktivaciju koji mogu doprinijeti oštećenju vaskularne funkcije. Hipoteza ovog projektnog prijedloga je postojanje interakcije između niske koncentracije ANG II (zbog visokog unosa kuhinjske soli) i aktivnosti simpatikusa u povišenju razine oksidativnog stresa s posljedičnim oštećenjem endotelne funkcije, aktivacije leukocita te smanjenje mikrovaskularne reaktivnosti in vivo. Istraživanje će se provoditi na mladim zdravim pojedincima oba spola. Navedenu hipotezu istražit ćemo u dva glavna cilja: Cilj 1 – sistemskim in vivo pokusima razlučiti učinak inhibicije RAS-a (kratkotrajnom dijetom s visokim udjelom soli) na mikrovaskularnu reaktivnost i aktivnost simpatikusa, s naglaskom na povišenu razinu oksidativnog stresa u navedenim promjenama, u zdravih mladih pojedinaca oba spola; i Cilj 2 – odrediti učinak inhibicije RAS-a na interakciju između endotelnih stanica i leukocita, kao i na distribuciju progenitornih endotelnih stanica u krvi u zdravih mladih pojedinaca oba spola. Rezultati ovog istraživanja mogli bi pružiti dokaz kako oštećenje mehanizama normalne vaskularne relaksacije i endotelno-leukocitne aktivacije imaju presudnu ulogu u razvoju kardiovaskularnih bolesti, posebice onih u kojima je RAS inhibiran a aktivnost adrenergičkog sustava promijenjena. ]]></summary_hr><summary_en><![CDATA[Recent studies have shown that inhibition of renin-angiotensin system (RAS) and low angiotensin II (ANG II) level induced by high salt (HS) intake affect endothelial function and microvascular reactivity in healthy individuals (in the absence of increased blood pressure) probably by increasing oxidative stress level. However, does RAS inhibition affect adrenergic system in healthy individuals, and whether this changes can contribute to increased oxidative stress level in developing endothelial dysfunction remains to be investigated. It has been suggested that RAS inhibition due to HS intake may acts as a trigger for the inflammatory process inception and endothelial-leukocyte activation which contributes to the impairment of vascular function. In this project we will test the hypothesis that there is an interaction of decreased levels of ANG II (due to HS intake) and sympathetic activity leading to endothelial and leukocyte activation by increasing oxidative stress, and further, impaired microvascular reactivity in humans in vivo. Study will be performed in young healthy human subjects of both sexes. This hypothesis will be investigated in two general aims: Aim 1 - to elucidate the effect of RAS inhibition (with short-term HS diet) on microvascular reactivity and sympathetic activity (with emphasis on increased oxidative stress in observed changes) in young healthy subjects of both sexes, systemically in vivo; and in the Aim 2 - to determine the effect of RAS inhibition on endothelial cells and leukocytes interactions, as well as on endothelial progenitor cells blood distribution in young healthy subjects of both sexes. The results may provide evidence that the impairment of normal vascular relaxation mechanisms and endothelial-leukocyte activation could play crucial role in increased risk of cardiovascular disease development, particularly in condition when RAS is inhibited and adrenergic system activity changed. ]]></summary_en></project><project>
<id>4179</id><title_hr><![CDATA[NOVI I ZAPOSTAVLJENI VIRUSNI UZROČNICI INFEKCIJA DIŠNOG SUSTAVA U VULNERABILNIM SKUPINAMA BOLESNIKA]]></title_hr><title_en><![CDATA[NEW AND NEGLECTED RESPIRATORY VIRUSES IN VULNERABLE GROUPS OF PATIENTS]]></title_en><user_id>2562</user_id><user_firstLast_name>Sunčanica Ljubin Sternak</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2016-06</proposal_call><code>IP-2016-06-7556</code><acronim><![CDATA[RESPIVIRUS]]></acronim><duration>01.03.2017 - 31.08.2021</duration><status>Završio</status><financ_value>125.569,05 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Javno zdravstvo i zdravstvena zaštita, Kliničke medicinske znanosti, </scie_field_hr><scie_field_en>Public health and health services, Clinical sciences, </scie_field_en><institution_hr><![CDATA[Nastavni zavod za javno zdravstvo Dr. Andrija Štampar, Zagreb]]></institution_hr><institution_en><![CDATA[Andrija Stampar Teaching Institute of Public Health, Zagreb]]></institution_en><team_members_id>19327, 19647, 12641, 19359, 409, 19323, 3210, 19394, 19674, 19567, 19462, 19693, 25051, </team_members_id><team_members_names><![CDATA[Gordana Mlinarić-Galinović, Ann Regina Falsey, Jasmina Vraneš, Amarela Lukić-Grlić, Branko Kolarić, Irena Ivković-Jureković, Rok Čivljak, Irena Tabain, Ivana Lukšić, Zvonimir Barišić, Tatjana Marijan, Tatjana Tot, Maja Mijač, ]]></team_members_names><keywords_hr><![CDATA[respiratorne infekcije, prevencija rezistencije, djeca, stariji bolesnici,  multiplex PCR, metapneumovirus, bokavirus, parehovirus]]></keywords_hr><keywords_en><![CDATA[respiratry infections,  prevention of resistance, children, elderly, multiplex PCR, metapenumovirus, bocavirus, parechovirus]]></keywords_en><summary_hr><![CDATA[Akutne infekcije dišnog sustava (ARI) najčešće su infekcije ljudi svih dobnih skupina, a kako su većinom uzrokovane virusima, najčešći su razlog nepotrebnog propisivanja antibiotika – jednog od vodećih javno zdravstvenih problema. ARI su osobito značajan uzrok pobolijevanja i smrtnosti  vulnerabilnih skupina bolesnika kao što su djeca kod kojih na ishod bolesti utječe mali promjer dišnih puteva i nezrelost imunog sustava i osobe starije dobi koje su opterećene kroničnim bolestima i procesom imunosenscencije. Virusne ARI od bakterioloških nije moguće razlučiti bez specifične virološke dijagnostike. Razvoj pak metoda laboratorijske dijagnostike doveo je do otkrića novih virusnih uzročnika ARI (metapneumovirus, bokavirus, novi koronavirusi) ali i omogućio detekciju mnogih do sada teško dokazivih i zbog toga zapostavljenih uzročnika (respiratorni enterovirusi, parehovirusi, virus parainfluence tip 4). Nadalje, zbog osjetljivosti molekularnih metoda dijagnostike, višestruka detekcija uzročnika u istom uzorku je sve češća, a pitanje prepoznavanja pravog patogena tijekom koinfekcije postaje imperativ. Cilj ovog projektnog prijedloga je utvrditi epidemiološke karakteristike i kliničko značenje 15 virusnih uzročnika ARI (virusi influence tipovi A i B, parainfluence tipovi 1-4, respiratorni sincicijski virus A i B, metapneumovirus, adenovirus, koronavirusi 229E/NL63 i OC43/HKU1, enterovirus, rinovirus i parehovirus) s posebnim osvrtom na novootkrivene i zapostavljene virusne uzročnike, u vulnerabilnim skupinama bolesnika multipleks PCR metodom. Kao doprinos prepoznavanju pravog respiratornog patogena u  infekcijama s više virusnih uzročnika, odrediti će se količina virusa u respiratornom sekretu. Krajnji doprinos ovog projekta je poduprijeti javno zdravstvene mjere koje se poduzimaju u svrhu promjene uobičajene prakse rutinskog propisivanja antibiotika za liječenje ARI u korist dijagnostike virusnih infekcija, a s dugoročnim ciljem prevencije bakterijske rezistencije.]]></summary_hr><summary_en><![CDATA[Acute respiratory infections (ARIs) are the most common infections in humans of all ages, and although viruses cause the majority of ARIs, they are the main reason for overuse of the antibiotics that represent one of the main public health issues today. ARI are particularly significant cause of morbidity and mortality of vulnerable patient groups such as children in whom the outcome of the disease affects the small size of their airways and the immaturity of the immune system, and elderly people who are burdened with chronic diseases and imunosenescence. Without specific viral diagnostics, it is not possible to distinguish between viral and bacterial ARI. Rapid advance of laboratory methods has led to the discovery of new viruses (metapneumovirus, bocavirus), and has enabled diagnosis of laboratory demanding and thus neglected viruses (enterovirus, parechovirus, parainfluenza type 4). Due to high sensitivity of molecular methods, simultaneous detection of multiple pathogens is more common, and question of recognizing the true pathogen in co-infection becomes imperative. The aim of this project is to determine the epidemiological characteristics and clinical significance of 15 viral pathogens causative agents of ARI (influenza A and B, parainfluenza 1-4, respiratory syncytial virus A and B, metapneumovirus, adenovirus, coronaviruses 229E/NL63 and OC43/HKU1, enterovirus, rhinovirus and parechovirus) with special emphasis on newly discovered and neglected pathogens, in vulnerable patient groups, using multiplex PCR method. As a contribution to the recognition the true respiratory pathogen in multiple viruses’ coinfection, the amount of viruses in respiratory secretions will be determined. The ultimate goal of this project is to contribute to the public health efforts to change the medical doctor’s routine decisions against prescription of antibiotics for ARIs in favor of viral diagnosing, which would contribute to the prevention of bacterial resistance.]]></summary_en></project><project>
<id>4194</id><title_hr><![CDATA[Novi oralni antikoagulansi: povezanost koncentracije lijeka i antikoagulantnog učinka]]></title_hr><title_en><![CDATA[New oral anticoagulants: relationship between drug concentration and anticoagulant effect  ]]></title_en><user_id>19440</user_id><user_firstLast_name>Sandra Margetić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2016-06</proposal_call><code>IP-2016-06-8208</code><acronim><![CDATA[LAB-NOAC]]></acronim><duration>01.04.2017 - 30.09.2022</duration><status>Završio</status><financ_value>79.633,69 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Javno zdravstvo i zdravstvena zaštita, Kliničke medicinske znanosti, </scie_field_hr><scie_field_en>Public health and health services, Clinical sciences, </scie_field_en><institution_hr><![CDATA[Klinički bolnički centar "Sestre Milosrdnice", Zagreb]]></institution_hr><institution_en><![CDATA[Clinical Hospital Center "Sestre Milosrdnice", Zagreb]]></institution_en><team_members_id>1176, 7013, 4780, 6134, 19963, 19941, 19931, 5168, 25110, 19873, 28925, </team_members_id><team_members_names><![CDATA[Arijana Lovrenčić-Huzjan, Vanja Bašić Kes, Diana Delić-Brkljačić, Ivana Ćelap, Ana Bronić, Ivana Vuga Vuga, Nikola Pavlović, Silvio Bašić, Marija Brčić, Sandra Šupraha Goreta, Esmat Elabjer, ]]></team_members_names><keywords_hr><![CDATA[novi antikoagulantni lijekovi, izravni inhibitori trombina, izravni inhibitori FXa, laboratorijske pretrage, koncentracija lijeka]]></keywords_hr><keywords_en><![CDATA[new anticoagulant drugs, direct thrombin inhibitors, direct inhibitors of FXa, laboratory assays, drug concentration  ]]></keywords_en><summary_hr><![CDATA[Novi oralni antikoagulansi (NOAK), uključujući izravni inhibitor trombina (dabigatran) i izravne inhibitore faktora Xa (rivaroksaban i apiksaban), posljednjih su godina uvedeni u prevenciju i liječenje tromboembolijskih bolesti. Iako se doziranje NOAK lijekova ne temelji na rezultatima laboratorijskih pretraga, pa rutinsko praćenje terapije nije potrebno, prva klinička iskustva nametnula su brojne rasprave o potrebi procjene antikoagulantnog učinka NOAC lijekova u određenim kliničkim situacijama. Stoga su osnovni ciljevi predloženog projekta istraživanje povezanosti koncentracije lijeka i učinka liječenja i definiranje kliničkih stanja u kojima bi bilo neophodno ili korisno određivati koncentraciju lijeka. U istraživanje planiramo uključiti bolesnike liječene NOAK  lijekovima u svim odobrenim kliničkim indikacijama, uključujući prevenciju i liječenje venske tromboembolije, te prevenciju moždanog udara i sistemne embolije u bolesnika s nevalvularnom fibrilacijom atrija. Metode istraživanja uključiti će specifične kvantitativne koagulacijske pretrage određivanja koncentracije lijeka: razrijeđeno trombinsko vrijeme za lijek dabigratan i aktivnost FXa za lijekove rivaroxaban i apixaban, uz istodobnu primjenu dvaju komercijalnih kvantitativnih testova za svaki pojedini lijek. Važnost rezultata predloženog istraživanja je u ispitivanju i usporedbi kvantitativnih metoda određivanja koncentracije NOAK lijekova te u definiranju kliničkih situacija u kojih bi se određivanje koncentracije lijeka pokazalo klinički značajnim. Rezultati istraživanja omogućili bi i osnovu za kreiranje smjernica u implementaciji kvantitativnih koagulacijskih pretraga određivanja koncentracije NOAK-a na nacionalnoj razini. Očekujemo da će dobiveni rezultati značajno unaprijediti spoznaje o liječenju bolesnika NOAC lijekovima, razumijevanje rezultata kvantitativnih metoda određivanja koncentracije NOAK lijekova te primjenu standardiziranih protokola u praćenju liječenja i u daljnjim istraživanjima. ]]></summary_hr><summary_en><![CDATA[New oral anticoagulants (NOACs), including direct thrombin inhibitor (dabigratan)and direct inhibitor of FXa (rivaroxaban and apiksaban), have recently been introduced in the prevention and treatment of thromboembolic diseases. Although dosage of NOACs is not based on the laboratory test results, thus making routine therapy monitoring not necessary, current clinical experience has imposed numerous discussions about the need of measuring their anticoagulant effect  in certain clinical situations. Therefore, the main goals of the proposed project are to study the relationship between drug concentration and effect of treatment and to highlight and define clinical conditions in which it would be required or useful to determine drug concentration. We plan to involve patients treated with NOACs in all approved clinical indications, including prevention and treatment of venous thromboembolism and prevention of stroke and systemic embolism in patients with non-valvular atrial fibrillation. Research methods will include specific quantitative coagulation assays for drug concentration determination: diluted thrombin time for dabigatran and anti FXa activity for rivaroxaban and apixaban, with simultaneous application of two commercial quantitative assays for each NOAC. The importance of the results is to evaluate and compare quantitative methods for determining concentration of NOACs and to define clinical situations in which determination of drug concentration would show clinical significance. The results would enable a basis for creation of guidelines for the implementation of quantitative coagulation assays in defined clinical situations at national level. We expect that the results will significantly improve the knowledge related to the treatment of patients with NOACs, understanding the results of specific quantitative methods for determining drug concentrations, as well as implementation of standardized protocols in patient treatment and further research.]]></summary_en></project><project>
<id>4198</id><title_hr><![CDATA[Genomički aspekti brze evolucije primorske gušterice (Podarcis sicula)]]></title_hr><title_en><![CDATA[Genomic aspects of rapid evolution of Italian wall lizard (Podarcis sicula)]]></title_en><user_id>19008</user_id><user_firstLast_name>Anamaria Štambuk Štambuk</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2016-06</proposal_call><code>IP-2016-06-9177</code><acronim><![CDATA[GENRALIZ]]></acronim><duration>01.03.2017 - 31.08.2021</duration><status>Završio</status><financ_value>132.722,81 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Biologija, </scie_field_hr><scie_field_en>Biology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>13161, 19725, 19930, 19471, 19735, 19712, 19714, 19995, 20103, 25018, 855618, 24034, </team_members_id><team_members_names><![CDATA[Duje Lisičić, Ivan Cizelj, Zoran Tadić, Dorotea Polović, Maja Šrut, Anthony Herrel, Jessica Stapley, Stuart Dennis, Miguel  Baltazar Soares, Iva Sabolić, Oscar Mira Perez, Marko Glogoški, ]]></team_members_names><keywords_hr><![CDATA[adaptivna evolucija, populacijska genomika, selekcija, evolucijska ekologija, fenotipska evolucija, Lacertidae, otoci, morfologija guštera, prehrana]]></keywords_hr><keywords_en><![CDATA[adaptive evolution, population genomics, selection, evolutionary ecology, phenotypic divergence, Lacertidae, islands, lizard morphology, diet]]></keywords_en><summary_hr><![CDATA[Sposobnost vrsta da nastanjuju nove okoliše ovisi u najvećoj mjeri o sposobnosti jedinki da se prilagode drugačijim ekološkim uvjetima. Razumijevanje mikroevolucijskih procesa koji određuju brzu adaptivnu evoluciju, kao i načina na koji selekcija oblikuje fenotipsku divergenciju u prirodnim populacijama i dalje je jedan od glavnih ciljeva evolucijske biologije. Ovaj projekt implementira dosadašnja saznanja o povijesti kolonizacije i ekološki uvjetovanoj fenotipskoj divergenciji populacija gušterice Podarcis sicula na otocima Lastovskog arhipelaga (Jadran) u istraživanje evolucijskih procesa koji uvjetuju brze fenotipske promjene u populacijama izloženim novim okolišnim uvjetima.  Ukratko, 1971. godine proveden je pokus u kojem je pet parova  gušterica P. sicula premješteno s njihovog nativnog otoka Pod Kopište na susjedni otok Pod Mrčaru. 35 godina nakon introdukcije za populaciju gušterica u novom okolišu utvrđena je nevjerojatna fenotipska divergencija u morfologiji i ekologiji, uzrokovana prijelazom s insektivorne na omnivornu prehranu. Ciljevi ovog projekta su: odrediti da li su te fenotipske promjene posljedica genetičkih promjena ili fenotipske plastičnosti, te saznati, proučavanjem dodatnih prirodnih populacija, kako fenotipska divergencija i učinak uskog grla utječu na genomičku divergenciju populacija gušterica P. sicula. Eksperimentalni i analitički okvir projekta, koji se bazira na pokusima križanja, pokusima „zajedničkog okoliša“ te populacijskoj genomici, omogućit će nam da testiramo da li 1) brzo evolvirajuća adaptivna fenotipska obilježja koja su omogućila prijelaz u prehrani gušterica s otoka Pod Mrčaru imaju genetičku osnovu, te da li su 2) jaka selekcija i učinak uskog grla  ostavili jasan otisak na genomičku divergenciju između populacija.]]></summary_hr><summary_en><![CDATA[The successful establishment of a species in novel environment depends on the capacity of individuals to cope with the novel conditions. Understanding the microevolutionary processes underlying rapid adaptive evolution and the way selection shapes phenotypic divergence in natural populations remains one of the major goals of evolutionary biology. In the proposed project we leverage the relatively well known colonisation history, and knowledge on ecologically induced phenotypic divergence of populations of the lizard Podarcis sicula that inhabit islands of the Lastovo archipelago (Adriatic) to study the evolutionary events driving rapid phenotypic shifts in populations encountering novel environments. Briefly, in 1971 a transplant experiment was conducted in which five pairs of P. sicula were introduced from their native island Pod Kopište onto a nearby islet, Pod Mrčaru. In 35 years since their introduction those populations exhibited spectacular phenotypic divergence in morphology and ecology, linked to a dietary shift from an insectivorous to an omnivorous diet. This project aims to identify if this phenotypic shift is due to genetic changes or phenotypic plasticity, and to investigate additional populations to understand how rapid phenotypic divergence and population bottlenecks influence genomic divergence amongst P. sicula populations. The experimental and analytical framework based on common garden experiments and population genomics will enable us to test whether 1) the rapidly evolved and adaptive phenotypic traits that facilitate a dietary shift in lizards from Pod Mrčaru have a genetic basis, and 2) if strong selection and population bottlenecks left distinct signatures of genomic divergence between populations.]]></summary_en></project><project>
<id>4202</id><title_hr><![CDATA[NUMERIČKI EFIKASNI RAČUNALNI ALGORITMI ZA UGRADBENE MULTI-FIZIKALNE SUSTAVE U VEKTORSKIM PROSTORIMA I NA MNOGOSTRUKOSTIMA]]></title_hr><title_en><![CDATA[NUMERICALLY EFFICIENT COMPUTATIONAL ALGORITHMS FOR EMBEDDED MULTI-PHYSICAL SYSTEMS IN VECTOR SPACES AND MANIFOLDS]]></title_en><user_id>7734</user_id><user_firstLast_name>Zdravko  Terze</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2016-06</proposal_call><code>IP-2016-06-6696</code><acronim><![CDATA[NUMECA4EMBEDDED]]></acronim><duration>20.03.2017 - 19.08.2021</duration><status>Završio</status><financ_value>126.119,85 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Zrakoplovstvo, raketna i svemirska tehnika, Strojarstvo, </scie_field_hr><scie_field_en>Aerospace, missile and space engineering, Mechnical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet strojarstva i brodogradnje]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Mechanical Engineering and Naval Architecture]]></institution_en><team_members_id>20301, 20336, 19369, 19367, 20025, 20027, 20065, 20307, 23235, 28668, </team_members_id><team_members_names><![CDATA[Milan Vrdoljak, Dubravko Matijašević, Dario Zlatar, Viktor Pandža, Andreas Mueller, Carlo Luigi Bottasso, Arnold Martin, Pierangelo Masarati, Marijan Andrić, Marko Kasalo, ]]></team_members_names><keywords_hr><![CDATA[geometrijska integracija, računanje u stvarnom vremenu, ugradbeni sustav, redukcija modela, sustav više tijela, interakcija fluida i strukture]]></keywords_hr><keywords_en><![CDATA[geometric integration, real-time simulation, embedded system, model reduction, multibody system, fluid-structure interaction]]></keywords_en><summary_hr><![CDATA[Razvoj numerički efikasnih simulacijskih modela za rad u stvarnom vremenu predmet je velikog interesa istraživača tijekom poslijednjih godina. S obzirom na stalni razvoj suvremenih tehnologija temeljenim na primjeni sve složenijih ugradbenih sustava, povećale su se i potrebe za simulacijskim modelima takvih složenih objekata, pri čemu se dinamika različitih multi-fizikalnih modela simulira unutar zajedničkog algoritma u stvarnom vremenu. Za razliku od jednostavnijih mehaničkih sustava, čije se procesiranje u stvarnom vremenu može postići konvencionalnim računalnim metodama, spregnuti multi-fizikalni sustavi zahtjevaju napredne algoritme koji su predmet intenzivnih istraživanja.Tijekom ovog projekta, uz standardne računalne formulacije u vektorskim prostorima, istražit će se i geometrijski numerički algoritmi na mnogostrukostima i Lievim grupama u svrhu razvoja numerički efikasnih simulacijskih procedura za multi-fizikalne ugradbene sustave. Posebna zadaća će se posvetiti ciljem vođenim zadaćama redukcije spregnutih modela, geometrijskim integracijskim algoritmima koji održavaju diferencijalno-geometrijsku strukturu dinamike spregnutih sustava, efikasne implementacije na specifičnom hardveru. Kada god je to opravdano, provest će se usporedba novorazvijenih geometrijskih numeričkih procedura s konvencionalnim formulacijama u vektorskim prostorima, a posebno u području redukcije multi-fizikalnih modela i optimiranih integracijskih procedura. Nakon odabira najprikladnijih algoritama, projektom će se istražiti prikladni hardver za ciljem vođene platformske (‘on-line’) računalne simulacije dinamike ugradbenih sustava. U toj fazi istraživanja, odabrat će se prikladna programska paradigma za novorazvijene algoritme i numerički eksperimenti. Poslijednja faza projekta obuhvatit će dizajn eksperimentalnih postava za odabrane multi-fizikalne ugradbene sustave s ciljem validacije numeričke efikasnosti, upravljivosti i stabilnosti novorazvijenih računalnih algoritama i procedura.]]></summary_hr><summary_en><![CDATA[Development of the numerically efficient simulation models capable of running in real-time has been a particular focus for researchers and industrial developers during the last decade. With the constant developments in the field of embedded systems, the demand for real-time simulation models of complex mechanical systems, where dynamics of different multi-physical models needs to be co-simulated within the same framework, became even larger. While conventional modelling techniques are suitable for simulating simpler tasks, coupled mechanical systems require more advanced techniques than those still being used.In this project, geometric numerical algorithms formulated on manifolds and Lie groups, as well as standard vector space formalisms, will be investigated in order to design efficient simulation procedures for multi-physical dynamics of the embedded systems. To this end, special attention will be devoted to the issues such as objective-based model reduction, structure preserving integration schemes, efficient numerical techniques and hardware-oriented code implementation. Whenever justified, novel differential-geometric computational procedures will be numerically tested against the standard vector space formalisms, especially in the context of the multi-physics model reduction and optimized integration schemes. Once the most appropriate computational models and numerical algorithms are selected during off-line simulations of the real-time dynamical processes, the project will focus on investigation of the suitable hardware platforms for the objective-based on-board simulations. This step also includes selection of the programming paradigm for the selected algorithms, as well as numerical tests. Within the last phase, the experimental implementation, comprising building of the testbed for the selected multi-physical embedded systems will be conducted in order to validate the numerical efficiency, controllability, and stability of the overall installations.]]></summary_en></project><project>
<id>4208</id><title_hr><![CDATA[Matične stanice usne šupljine čovjeka za liječenje ishemijske bolesti mozga]]></title_hr><title_en><![CDATA[Stem cells from human oral mucosa for treatment of brain ischemia ]]></title_en><user_id>12653</user_id><user_firstLast_name>Dinko Mitrečić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2016-06</proposal_call><code>IP-2016-06-9451</code><acronim><![CDATA[ORASTEM]]></acronim><duration>01.10.2017 - 01.11.2022</duration><status>Završio</status><financ_value>132.722,81 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb School of Medicine]]></institution_en><team_members_id>5987, 12687, 5175, 12852, 19754, 4133, 12711, 354, 13179, 19740, 12716, 19613, 12682, 19823, 19657, 7666, 25391, 28671, 858356, </team_members_id><team_members_names><![CDATA[Ivan Alajbeg, Ivan Alić, Ana Andabak Rogulj, Ervina Bilić, Vlaho Brailo, Ivan Domagoj Drmić, Dunja Gorup, Anja Kafka, Katarina Kapuralin, Eva Klarić Sever, Nicaise Charles, Sandu Pitaru, POCHET Roland, Ivana  Rosenzweig, Ivana Savić Pavičin, Zrinka  Tarle, Valentina Hribljan, Denis Jagečić, Paula Stančin, ]]></team_members_names><keywords_hr><![CDATA[moždani udar, matične stanice, sluznica usne šupljine, regenerativna medicina, transkriptom ]]></keywords_hr><keywords_en><![CDATA[stroke, stem cells, oral mucosa, regenerative medicine, transriptome]]></keywords_en><summary_hr><![CDATA[Ishemijska ozljeda mozga je najčešći oblik moždanog udara te predstavlja jedan od najvećih medicinskih problema čovječanstva. U ovom projektu ćemo po prvi put istražiti terapijski potencijal nedavno otkrivenih ektodermalnih matičnih stanica ljudske sluznice usne šupljine (SOS) na modelu ishemije mozga miša. U preliminarnim pokusima smo pokazali da se ove stanice lako dobivaju iz sluznice usne šupljine pacijenta, a zbog svojeg ektodermalnog podrijetla daju živčane i glija stanice. Nakon dobivanja stanica u suradnji sa Stomatološkim fakultetom u Zagrebu, analizirat ćemo njihovo umnažanje, diferencijacijski potencijal i preživljenje tijekom rasta in vitro. Biljege diferencijacije ćemo analizirati RT-PCRom i imunohistokemijom u periodu od 14 dana, a rezultati dobiveni u normalnim uvjetima će se usporediti sa onima u uvjetima hipoksije. Razlike u odgovoru stanica na ishemiju će biti analizirane na razini transkriptoma koja će biti učinjena u suradnji s New York University Abu Dhabi. U idućoj grupi pokusa ćemo transplantirati SOS u mišji model moždanog udara. U dvije vremenske točke, 7 i 30 dana nakon transplantacije ćemo opisati njihovo preživljenje, migraciju i diferencijaciju. Miševi tretirani mišjim živčanim matičnm stanicama, ljudskim stanicama sluznice usne šupljine te netretirani miševi će biti uspoređeni - oslikani na magnetnoj rezonanci (Bruker 7T) i praćeni u nizu testova zdravstvenog statusa. Na taj način ćemo zaključiti o brzini njihovog oporavka. Očekujemo da će matične stanice usne šupljine čovjeka zbog svojeg podrijetla, pozitivnih rezultata na modelima neurodegeneracije i ozljede te naših preliminarnih rezultata pokazati visok potencijal za liječenje ishemijske bolesti mozga. Ukoliko se naša hipoteza potvrdi, ove će stanice zbog svoje dostupnosti, ektodermalnog podrijetla i terapijskog potencijala biti predložene kao stanice prvog izbora u kliničkim pokusima na pacijentima oboljelima od moždanog udara. ]]></summary_hr><summary_en><![CDATA[Ischemic brain damage is the most common form of stroke and represents one of the largest medical problems of the human society. In this project we will, for the first time, analyze therapeutic potential of recently discovered ectodermal stem cells from the oral mucosa (hOMSC) for treatment of brain ischemia. In preliminary experiments we have shown that hOMSC can be easily isolated from the mouth cavity of the patients and because of their origin – they give rise to neurons and glia. After isolation of cells, in collaboration with University of Zagreb School of Dentistry, we will analyze cell proliferation, differentiation potential and survival during cultivation in vitro . We will analyze markers of differentiation by immunhistochemistry and RT PCR in the period of 14 days and results obtained in normal conditions will be compared to in vitro hypoxia. Difference in cell response will be additionally analyzed on the level of transcriptome  which will be performed by New York University Abu Dhabi. In the next group of experiments we will transplant hOMSC in the animal model of stroke. In two time points, 7 and 30 days after transplantation we will describe their survival, migration and differentiation. Mice treated by hOMSC, NSC and untreated group will be tested in standardized tests of mouse Health status and imaged on MRI (Bruker, 7T). This will allow to conclude about histological and functional recovery of tested mice. We expect that, based on their embryonic origin, positive results on animal models of neurodegeneration and nerve damage and our promising preliminary results, hOMSC will exhibit beneficial effects for animals affected by stroke. If our hypothesis will be confirmed, hOMSC will be, because of their easy access, ectodermal origin and therapeutic potential, suggested as the perfect candidate for clinical trials on patients affected by stroke. ]]></summary_en></project><project>
<id>4209</id><title_hr><![CDATA[Hrvatska longitudinalna studija tjelesne aktivnosti u adolescenciji]]></title_hr><title_en><![CDATA[Croatian Physical Activity in Adolescence Longitudinal Study]]></title_en><user_id>523</user_id><user_firstLast_name>Marjeta Mišigoj-Duraković</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2016-06</proposal_call><code>IP-2016-06-9926</code><acronim><![CDATA[CRO-PALS]]></acronim><duration>01.12.2016 - 30.11.2020</duration><status>Završio</status><financ_value>78.683,92 eur</financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Kineziologija, Psihologija, </scie_field_hr><scie_field_en>Kinesiology, Psychology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Kineziološki fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Kinesiology]]></institution_en><team_members_id>1126, 3761, 13488, 6355, 3710, 4051, 13335, 13301, 25220, 23764, 7293, 28634, </team_members_id><team_members_names><![CDATA[Maroje Sorić, Zvonimir Šatalić, Renata Barić, Tatjana Trošt Bobić, Dario Novak, Vilko Petrić, Antonela Devrnja, Hrvoje Podnar, Josip Karuc, Lovro Štefan, Ivan Radman, Marija Martina Glavaš, ]]></team_members_names><keywords_hr><![CDATA[tjelesna neaktivnost, zdravlje, pretilost, sedntarna ponašanja, mladež]]></keywords_hr><keywords_en><![CDATA[inactivity, health, obesity, sedentarism, youth]]></keywords_en><summary_hr><![CDATA[Nedovoljna tjelesna aktivnost (TA) na četvrtom je mjestuvodećih rizika smrtnosti u svijetu. Tijekom adolescencijesmanjuje se u oba spola, a determinante i ishodi tog smanjenjanisu u potpunosti razjašnjeni. Stoga su ciljevi ovog istraživanja:analizirati obrasce promjena TA tijekom adolescencije; identificirati determinante TA i sedentarnih ponašanja tijekom ovog razdoblja; istražiti povezanost TA i sedentarnih ponašanja sa nekim sa zdravljem povezanim ishodima; identificirati moderatore tih povezanosti. Ovaj projekt se naslanja na tekuće longitudinalno istraživanje koje je započelo 2014. godine, a obuhvaća  903 učenika iz 14 slučajno odabranih zagrebačkih srednjih škola. TA i sedentarna ponašanja se procijenjuju SHAPES upitnikom i pomoću multisenzornog monitora TA (the SenseWear Armband).Za evaluaciju motivacije koristit se &#39;The Motives for Physical Activity Measure- Revised&#39; upitnik. Trajanje spavanja ispituje se SWA monitorom i upitnikom. Dijetetske metode uključuju 24-h prisjećanje unosa hrane i upitnik o učestalosti unosa hrane. BMI, WHR i % tjelesne masti računaju se temeljem antropometrije.Krvni tlak mjeri se u skladu s ESH preporukama, a pušenje i socio-ekonomski faktori procijenjuju se upitnicima. Subjektivni osjećaj zdravlja ispituje se hrvatskom verzijom upitnika KIDSCREEN-27, a koncept mentalnog zdravlja primjenom &#39;&#39;TheStrengths and Difficulties Questionnaire&#39;&#39;. Mjeru školskog uspjeha čini prosjek ocjena na kraju školske godine. Obrada podataka temeljit će se većinom na višerazinskom modeliranju za ponavljana mjerenja. Rezultati ovog projekta omogućit će bolje razumijevanje determinanti i moderatora TA i sedentarnih ponašanja u mladih. Nadalje, rasvijetlit će se relativna uloga TA i sedentarnih ponašanja u povezanostima sa zdravstvenim ishodima, što će doprinijeti i znanstveno utemeljenom planiranju ciljanih intervencijskih programa primarne prevencije kroničnih bolesti.]]></summary_hr><summary_en><![CDATA[Lack of physical (PA) is recognized as the fourth leading risk for global death. During adolescence PA declines in both genders. Still, determinants and outcomes of this decline remain to be clarified. The aims of this study are: to analyze patterns ofchange in PA during adolescence; to identify determinants and moderators of PA and sedentary behaviours in this period; to explore the effect of PA and sedentary behaviours on several health related outcomes; to examine how different correlates of PA moderate the effect of PA and sedentary behaviours on health-related outcomes. The project extends on the on-going prospective longitudinal study that started in 2014 and involves around 900 high school students from the city of Zagreb (Croatia). PA and sedentary behaviours are assessed annually during 4 years of high school education by the SHAPES questionnaire and by the SenseWear Armband multiple-sensor activity monitor. Motivation for PA is evaluated by &#39;The Motives for Physical Activity Measure - Revised&#39; and perceived health by the KIDSCREEN-27 questionnaire. Sleep is examined using several self-report instruments and by the SWA monitor. The 24-h dietary recall and a food frequency questionnaire are applied. BMI, WHR and body fat percentage will be calculated based on anthropometry. Blood pressure is  taken following ESH guidelines. Smoking and socioeconomic factors will be assessed through questionnaires. Mental health is evaluated by the Strengths and Difficulties Questionnaire; grade point average will be used as a measure of academic achievement. Data analytic techniques will mostly rely on multi-level modelling for repeated measures. The results of this study will aid in understanding PA decline in youth, its determinants and moderators. In addition, the relative importance of PA and sedentary behaviours for physical and mental health will be elucidated. Consequently, future interventions aimed at primary prevention of chronic diseases will be improved.]]></summary_en></project><project>
<id>4226</id><title_hr><![CDATA[Ravni Kotari: urbanizacija i promjene krajolika u sjevernoj Dalmaciji]]></title_hr><title_en><![CDATA[Ravni Kotari: Urbanization and Landscape Change in Northern Dalmatia]]></title_en><user_id>5152</user_id><user_firstLast_name>Martina Čelhar</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2016-06</proposal_call><code>IP-2016-06-5832</code><acronim><![CDATA[URBANIZACIJA]]></acronim><duration>20.03.2017 - 19.03.2020</duration><status>Završio</status><financ_value>53.335,31 eur</financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Arheologija, Povijest, Etnologija i antropologija, </scie_field_hr><scie_field_en>Archeology, History, Ethnology and anthropology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zadru]]></institution_hr><institution_en><![CDATA[University of Zadar]]></institution_en><team_members_id>20207, 4817, 20172, 20208, 20304, 26316, 26317, 26318, 26023, </team_members_id><team_members_names><![CDATA[Gregory Zaro, Igor Borzić, Karla Gusar, Ken Nystrom, Tajana Trbojević Vukičević, Luka Bogdanić, Antonela Klobučar, Vinka Milišić, Maja Grgurić, ]]></team_members_names><keywords_hr><![CDATA[Urbanizacija, krajolik, Ravni Kotari, sjeverna Dalmacija, Nadin-Gradina, željezno doba, antika, kasna antika, srednji vijek, novi vijek]]></keywords_hr><keywords_en><![CDATA[Urbanization, Landscape, Ravni Kotari, northern Dalmatia, Nadin-Gradina, Iron Age, Antiquity, Late Antiquity, Medieval period, Modern Era]]></keywords_en><summary_hr><![CDATA[Gradovi su danas dominantan faktor u globalnim promjenama okoliša, no kao dugotrajan proces urbanizacija je imala značajnu ulogu u oblikovanju krajolika i okoliša tijekom tisućljeća, efektivno stvarajući kulturne krajolike. Ova činjenica otvara prostor arheologiji da značajno doprinese suvremenim urbanim i ekološkim pitanjima, usput generirajući  međukulturalno znanje o procesu urbanizacije u širokom vremenskom okviru od kasne prapovijesti pa sve do suvremenog doba. Iako taj proces na prostoru istočnog Jadrana traje već nekoliko tisućljeća, on nije ni približno dovoljno rasvijetljen. Čak i Ravni Kotari, smješteni u zaleđu Zadra, tijekom antike nedvojbeno najurbaniziranija istočnojadranska regija, tek trebaju dobiti značajniju arheološku pažnju usmjerenu k istraživanju razvoja urbanizacije te njezina utjecaja na lokalne i regionalne promjene u krajoliku.Predloženi projekt je interdisciplinarne prirode te kombinira arheološka iskopavanja i analize s povijesnim i arhivskim istraživanjima, teritorijalnim studijama, bioarheološkim ispitivanjima, znanostima o okolišu, a sve da prouči proces urbanizacije i transformacije prostora Ravnih Kotara kroz vrijeme. Veći dio terenskih istraživanja će se odvijati na arheološkom lokalitetu Nadin-Gradina. Tamošnja situacija će se komparirati s poznatim podatcima vezanima također uz prostor Ravnih Kotara, ali i čitave istočne obale Jadrana zbog jasnije kontekstualizacije urbanog razvoja i promjena praćenih tijekom zadnja 3 tisućljeća. S obzirom na odličnu očuvanost arheološkog zapisa i naseobinsku aktivnost u trajanju od gotovo 2 500 godina, lokalitet Nadin-Gradina pruža odličnu mogućnost za istraživanje odnosa između pojedinih faza urbanog rasta i opadanja te širih promjena krajolika i okoliša. Rezultati projekta će proširiti znanje o dinamici razvoja kulturnog krajolika na istočnoj obali Jadrana te upotpuniti globalnu raspravu o urbanizaciji i promjenama krajolika kroz sva razdoblja ljudske povijesti. ]]></summary_hr><summary_en><![CDATA[Cities are a dominant factor in global environmental change today, but as a long-term process, urbanization has played a significant role in shaping our planet’s landscapes and environments for millennia, effectively creating anthropogenic landscapes. Recognition of this point opens the door for archaeological research to make significant contributions to contemporary urban/ecological issues while also generating cross-cultural knowledge about urbanism in the ancient, historic, and modern worlds. In the eastern Adriatic, this process has unfolded over the course of several thousand years but is not well understood. Even the Ravni Kotari region in Zadar&#39;s hinterland, arguably the most urbanized region along the entire coast in antiquity, has yet to receive significant archaeological attention regarding the process of urban growth and decline, or its articulation with and impact on local and regional landscape change. The proposed project is an interdisciplinary field research program that combines archaeological excavation and analysis with historical and archival research, geospatial studies, bioarchaeological investigation, and environmental science. The majority of field research will take place at the Nadin-Gradina archaeological site, but it will also draw comparatively from published work throughout the Ravni Kotari and eastern Adriatic to contextualize urban development and change around Nadin-Gradina over the course of three thousand years. With a nearly 2,500-year record of seemingly well-preserved occupational history, Nadin-Gradina offers an excellent opporunity to investigate the relationship between phases of urban growth and decline and broader changes in landscape and environment. The results of this project will help to build a range of knowledge concerning human-environment dynamics in the eastern Adriatic while also contributing to a global discussion on urbanization and landscape change in the ancient, historic, and modern worlds. ]]></summary_en></project><project>
<id>4228</id><title_hr><![CDATA[TFF3 protein na raskrižju metabolizma i neurodegeneracije]]></title_hr><title_en><![CDATA[TFF 3 protein at intersection of metabolism and neurodegeneration ]]></title_en><user_id>1263</user_id><user_firstLast_name>Mirela Baus Loncar</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2016-06</proposal_call><code>IP-2016-06-2717</code><acronim><![CDATA[Inter MeNe-3]]></acronim><duration>18.04.2017 - 17.03.2022</duration><status>Završio</status><financ_value>131.395,58 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>19273, 13089, 19240, 25290, 24803, </team_members_id><team_members_names><![CDATA[Friedrich Paulsen, Nikola Bijelić, Ivana  Lovrić, Iva Bazina, Kate Šešelja, ]]></team_members_names><keywords_hr><![CDATA[Tff3 protein, jetra, mozak, diabetes, neurodegeneracija, Alzheimerova bolest homeostaza  glukoze, stres endoplazmatskog retikuluma  ]]></keywords_hr><keywords_en><![CDATA[Tff3 protein, liver, brain, diabesity, neurodegeneracija, Alzheimer disasese, glucose homeostasis, endoplasmatic reticulum (ER) stress  ]]></keywords_en><summary_hr><![CDATA[Većina bolesti koje prate užurbani životni ritam su povezane sa poremećenim metabolizmom glukoze i lipida. Diabetes i Alzheimerova bolest (AB) su među najvećim prijetnjama današnjice. Obje bolesti  u podlozi imaju neosjetljivost na inzulin i zajedničke upalne signalne putove. Kliničke i pred kliničke studije pokazale su  da je AB degenerativna metabolička bolest, posredovana narušenim inzulinskim signaliziranjem u mozgu, poremećenim iskorištenjem glukoze i energetskog metabolizma koji dovode do oksidativnog stresa, upale i pogoršanja inzulinske  neosjetljivosti. Veza između diabetes/debljine i AB, može razjasniti mehanizam nastanka sporadične AB koja se javlja kod 90% AB pacijenata. Potraga za biomarkerima u likvoru  AB pacijenata otkrila  je  TFF3 protein (Trefoil factor family protein 3) kao mogućeg povezujućeg kandidata. Nova istraživanja pokazala su da bolest nealkoholna masna jetra izazvana masnom hranom u mišjem modelu može uzrokovati sve simptome AB uključujući i smrt neurona. Dramatično smanjenje razine Tff3 glasničke RNA u jetri uočena je u ranoj fazi diabetesa kod mišjeg modela diabetes Tipa 2 (Tally Ho). Tff3 protein je prisutan u neuronima a Tff3 iz jetre može djelovati neuroprotektivno i nakupljati se u mozgu nakon ozljede. Cilj ovog projekta je utvrditi ulogu Tff3 proteina u Jetri/mozgu koristeći Tff3 -/- mišji soj i modelirajući diabetesa tipa 1 i tipa 2. Korelirati ćemo učinak nedostatka Tff3 na jetru kao glavni metabolički organ i mozak (hippocampus/cortex),te pratiti specifične pokazatelje neurodegeneracije i stresa endoplazmatskog retikuluma. Koristeći novu tehnologiju (XFe96 Extracellular Flux Analyzer) utvrdit ćemo učinak Tff3 na mitohondrijsku respiraciju i glikolizu u živućim primarnim hepatocitima. Ovakav sistemski pristup pridonijeti će razumijevanju zajedničkih procesa koji se odvijaju u osnovi obje bolesti (diabetesa i neurodegeneracije), te potencijalno ukazati na nove terapijske mete. ]]></summary_hr><summary_en><![CDATA[Most of the diseases accompanying fast  life rhythm in developed countries are connected with  deregulated  lipid and glucose metabolism. Diabetes and Alzheimer’s disease (AD) are considered among top threats to human health and they both have in common insulin resistance and common inflammatory signaling pathways. Human and preclinical studies have provided convincing evidence that AD is a degenerative metabolic disease, mediated by impaired insulin responsiveness in the brain, glucose utilization and energy metabolism leading to increased oxidative stress, inflammation and worsening of insulin resistance. The connection between diabetes/obesity and AD, may shed light how sporadic AD develops. Biomarker search in cerebrospinal fluid of  AD  patients  identified  TFF3 protein as a new  possible candidate for this crosstalk. Novel research showed that non-alcoholic fatty liver disease provoked by High fat diet is able to induce hallmarks of AD and even neuronal death in wild type mice. Diminishment of liver Tff3 gene expression was noticed in early stage of diabetes in Tally Ho mouse model of Type 2 diabetes. Tff3 protein is present in neurons and liver produced Tff3 can act neuroprotective and concentrate in brain upon injury. In this project  proposal we will investigate impact of Tff3 protein in liver/brain axis using  Tff3 -/- mouse strain and modeling Type 1 and Type 2 diabesity conditions. We will correlate  the effect  of Tff3 deficiency on liver as major metabolic organ,  and hippocampus/cortex as affected brain regions is AD, monitoring neurodegenerative hallmarks and endoplasmatic reticulum stress markers. Using novel technology (XFe96 Extracellular Flux Analyzer) we will estimate impact of Tff3 on mitochondrial respiration and glycolysis in living primary hepatocytes. This systemic approach will help us understand common pathways in diabesity and neurodegeneration and possibly reveal novel therapeutic targets. ]]></summary_en></project><project>
<id>4231</id><title_hr><![CDATA[Pojavnosti moderne skulpture u Hrvatskoj: skulptura na razmeđima društveno-političkog pragmatizma, ekonomskih mogućnosti i estetske kontemplacije]]></title_hr><title_en><![CDATA[Manifestations of Modern Sculpture in Croatia: Sculpture on the Crossroads between Socio-political Pragmatism, Economic Possibilities and Aesthetical Contemplation]]></title_en><user_id>5489</user_id><user_firstLast_name>Dalibor Prančević</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2016-06</proposal_call><code>IP-2016-06-2112</code><acronim><![CDATA[CROSCULPTURE]]></acronim><duration>01.03.2017 - 29.02.2020</duration><status>Završio</status><financ_value>52.959,98 eur</financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Povijest umjetnosti, Povijest, </scie_field_hr><scie_field_en>Art history, History, </scie_field_en><institution_hr><![CDATA[Sveučilište u Splitu, Filozofski fakultet]]></institution_hr><institution_en><![CDATA[University of Split, Faculty of Humanities and Social Sciences]]></institution_en><team_members_id>3667, 19524, 19779, 4237, 19560, 6142, 7870, 19952, 6333, 24567, </team_members_id><team_members_names><![CDATA[Ivana  Mance, Barbara Vujanović, Davorin Vujčić, Daniel Zec, DARIJA ALUJEVIĆ, Ljiljana Kolešnik, Aleksandar Jakir, Božo Kesić, Sanja ¸Horvatinčić, Dora Derado, ]]></team_members_names><keywords_hr><![CDATA[skulptura, društvo, politika, estetika, povijest umjetnosti, centar, periferija, Hrvatska]]></keywords_hr><keywords_en><![CDATA[sculpture, society, politics, aesthetics, art history, center, periphery, Croatia]]></keywords_en><summary_hr><![CDATA[Cilj projekta je „dubinsko mapiranje“ moderne skulpture u Hrvatskoj kroz različite „prostorne“ i „vremenske“ slojeve, te sagledavanje specifičnih okolnosti unutar kojih se ona oblikovala. Kiparska produkcija u Hrvatskoj promatrala bi se ponajprije u odnosu na europsku umjetničku produkciju, istražilo bi se njezino snalaženje u neprekidnim promjenama kako državnih asocijacija tako i društveno-političkih paradigmi i politikâ identiteta, ali i nastajanje u posebnim ekonomskim prilikama. Istraživanjem bi se pratila i notirala kretanja kipara različitim europskim političkim i kulturnim geografijama. Cilj istraživačkog tima jest razviti nove metode opisivanja vremenskih, prostornih i terminoloških definicija moderne skulpture u Hrvatskoj. Fokus istraživanja kiparska je produkcija nastajala u razdoblju koje započinje na kraju 19. stoljeća i zaključuje se sedamdesetih godina 20. stoljeća. Pritom će se u razmatranje uzeti društvo, politika, ekonomija i estetika. U pripremi projektnog prijedloga uvažila se i činjenica kako je dobar dio kiparske produkcije u Hrvatskoj nastajao eksteritorijalno. Stoga bi se istraživanjem propitalo u kojoj mjeri i na koje načine su hrvatski kipari diseminirali nove pristupe angažmana u kiparstvu, koji su to specifični protagonisti i kako se i može li se kroz njihovo djelovanje postaviti okvir diskursa o „deprovincijalizaciji“ hrvatskog kulturnog prostora. Vizualizacije takvih odnosa realizirale bi se posebnim softverskim alatima, već poznatima području djelovanja digitalne humanistike. Nadalje, posebno bi se istražile i sve one pojave kiparstva isključene iz dominantnih narativa, poput primjerice rodnih pitanja. Zasebni dio projektnog prijedloga uključuje stvaranje rječnika skulpture dvadesetog stoljeća kojim bi se stvorio tezaurus termina što se vezuju uz pojavu skulpture i njezinu artikulaciju. Rezultati istraživanja bili bi predstavljeni na međunarodnim konferencijama i okruglim stolovima, te u objavljenim recenziranim radovima i knjigama.]]></summary_hr><summary_en><![CDATA[The aim of the project is to come to an “in-depth mapping” of Modern sculpture in Croatia, with regards to various „spatial“ and „time“ layers, as well as investigation of the specific context within which Modern sculpture was shaped. Sculptural production in Croatia is to be observed in relation to European art, and in the context of constant change of state associations, different socio-political paradigms and identity politics, but also in relation to the economic situation. The research also aims to trace the movement of sculptors and their work throughout various European political and cultural geographies. Research team aims to develop new descriptions of the terms of reference within time, spatial and terminological definitions of Modern sculpture in Croatia. The main research focus will be on sculptural production in the period beginning at the end of the 19th century until the 1970s. Society, politics, economy, aesthetics will be taken into consideration. During the preparation of the project proposal it became clear that a reasonable part of Croatian sculpture was created extraterritorially. This research will investigate how and to what measure Croatian sculptors disseminated new approaches to sculptural activity, who are the specific protagonists, and how is it possible to establish a discourse frame dealing with ”de-provincialisation” of Croatian cultural space. Visualisations of such relations are to be displayed using special software tools, well known in the area of digital humanities. Furthermore, the aim is to research all those phenomena in the domain of sculpture that were excluded from the dominant narratives, for example gender issues. Special part of the project includes generating 20th century sculpture vocabulary, in order to create a thesaurus of terms that are related to the manifestation of sculpture and its articulation. Research results will be presented at international conferences, via reviewed papers and in books.]]></summary_en></project><project>
<id>4232</id><title_hr><![CDATA[Razvoj novih antitijela (biološki lijek) koja selektivno inhibiraju izražaj hepcidina u jetri za terapiju anemije kronične bolesti]]></title_hr><title_en><![CDATA[Development of novel antibodies (biologics) that will selectively inhibit hepcidin expression in the liver for the Treatment of Anemia of Chronic Disease]]></title_en><user_id>7659</user_id><user_firstLast_name>Slobodan Vukičević</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2016-06</proposal_call><code>IP-2016-06-2169</code><acronim><![CDATA[BMP6Fe3]]></acronim><duration>01.07.2017 - 30.09.2022</duration><status>Završio</status><financ_value>132.722,81 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, Kliničke medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, Clinical sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb School of Medicine]]></institution_en><team_members_id>12659, 20189, 13334, 19452, </team_members_id><team_members_names><![CDATA[Igor Erjavec, IRENA POPEK, Hermann Oppermann, Ines Oršolić, ]]></team_members_names><keywords_hr><![CDATA[hepcidin, poremečaj metabolizma željeza, anemija kronične bolesti, BMP6, hemojuvelin]]></keywords_hr><keywords_en><![CDATA[hepcidin, iron metabolism alterations, anaemia of chronic disease, BMP6, hemojuvelin]]></keywords_en><summary_hr><![CDATA[Hepcidin je peptid od 25 aminokiselina sintetiziran u jetri te služi kao ligand za feroportin i regulira homeostazu željeza. U ovom projektu pokušat ćemo razviti terapiju za anemiju kronične bolesti (AKB) povezanu s poremećajem u metabolizmu željeza temeljem našeg nedavnog otkrića da BMP6 regulira sintezu hepcidina*. Također smo otkrili da feri (Fe3+) željezo utječe na promjenu strukture BMP6 čime povećava afinitet jetre za BMP koreceptor hemojuvelin (HJV) rezultirajući povećanim izražajem gena za hepcidin i posljedično sniženom razinom serumskog željeza (preliminarni neobjavljeni rezultati). Stoga pretpostavljamo da se željezo specifično veže na cirkulirajući BMP6 i uzrokuje strukturalne promjene stimulirajući vezanje BMP6-Fe3+ kompleksa na HVJ/BMPRI i povećani izražaj gena za hepcidin u jetri, te posljedično smanjenje razine serumskog željeza. U ovom projektu predlažemo novi znanstveni koncept za razumijevanje mehanizma kojim BMP6 &#39;&#39;prepoznaje&#39;&#39; željezo i razvoj nove terapijske platforme za liječenje AKB kroz slijedeće ciljeve: 1) identifikacija fiziološkog oblika BMP6 u cirkulaciji, 2) proizvodnja rekombinantnog humanog BMP6, 3) karakterizacija specifičnih vezivnih mjesta željeza na BMP6 proteinu, 4) proizvodnja visokoafinitetnog mišjeg i humanog protutijela na strukturno promijenjen BMP6 čime bi se spriječilo stvaranje kompleksa BMP6-HJV u jetri, i time postaviti temelje za 5) testirati novoproizvedena protutijela in vitro i in vivo u modelima anemije udružene s upalom i u modelu kronične bolesti bubrega. Stoga ćemo testirati novi koncept za razumijevanje mehanizma kojim BMP6 „prepoznaje“ željezo, i upotrijebiti taj fenomen da Fe3+/BMP6/HJV posredovan izražaj hepcidina može poduprijed razvoj prvog biološkog lijeka za AKB.* Andriopoulos B, Jr., et al. (2009) Nat Genet 41:482.]]></summary_hr><summary_en><![CDATA[Hepcidin is a 25 amino acid peptide synthesized in the liver and serves as a ligand for ferropoortin, an iron exporter, and thus regulates iron homeostasis. In this project, we aim to develop a therapy for anemia of chronic disease (ACD) associated with an altered iron metabolism based on our discovery that BMP-6 regulates hepcidin synthesis*. We showed that Bmp6-/- mice have decreased hepcidin synthesis in liver and this leads to abundant accumulation of iron in the organism (“hemochromatosis”), suggesting a key role of BMP-6 in hepcidin regulation and iron metabolism. We recently found that ferric (Fe3+) iron induces conformational changes in BMP-6 secondary and tertiary structure thereby exhibiting an high affinity (~4-fold) to BMP co-receptor hemojuvelin (HJV), which results in increased expression of hepcidin and subsequently a decrease of serum iron level (preliminary unpublished results). We propose a new scientific concept to unravel the mechanism by which BMP-6 “senses” iron and develop a novel therapeutic biologics for treating ACD by following objectives: 1) identify physiological forms of circulating BMP-6, 2) produce recombinant human BMP-6, 3) characterize iron specific BMP-6 binding sites, 4) develop high affinity mouse and human antibody to structurally changed BMP-6 in order to prevent the formation of BMP-6-HJV complex in the liver; and pave the path to 5) evaluate newly developed antibodies in vitro and in vivo against anemia associated with inflammation and in a model of chronic kidney disease. Thus, we seek to demonstrate novel concept for understanding the mechanism by which BMP-6 “senses” iron, and utilizes this phenomenon that curtailing Fe3+/BMP-6/HJV mediated hepcidin expression may help to develop the first-in class biologics for ACD. * Andriopoulos B, Jr., et al. (2009) Nat Genet 41:482.]]></summary_en></project><project>
<id>4233</id><title_hr><![CDATA[Nastajanje i svojstva 1D a-Fe2O3 nanostruktura dopiranih odabranim metalnim ionima]]></title_hr><title_en><![CDATA[Formation and properties of 1D a-Fe2O3 nanostructures doped with selected metal ions]]></title_en><user_id>1073</user_id><user_firstLast_name>Stjepko Krehula</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2016-06</proposal_call><code>IP-2016-06-8254</code><acronim><![CDATA[1D-DopedFeOX]]></acronim><duration>15.03.2017 - 14.03.2021</duration><status>Završio</status><financ_value>102.196,56 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, </scie_field_hr><scie_field_en>Chemistry, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>1073, 490, 4103, 5300, 615, 25288, 28878, </team_members_id><team_members_names><![CDATA[Stjepko Krehula, Željka Petrović, Marijan Marciuš, Ivana Opačak, Svetozar Musić, Nina Popov, Marko Robić, ]]></team_members_names><keywords_hr><![CDATA[a-Fe2O3, 1D nanostrukture, dopiranje, Mossbauerova spektroskopija, elektronska mikroskopija, magnetska svojstva, fotokataliza]]></keywords_hr><keywords_en><![CDATA[a-Fe2O3, 1D nanostructures, doping, Mossbauer spectroscopy, electron microscopy, magnetic properties, photocatalysis]]></keywords_en><summary_hr><![CDATA[U zadnje vrijeme 1D (jednodimenzijski) željezovi oksidi su predmet brojnih fundamentalnih istraživanja kojima se žele polučiti nova saznanja o kemijskim i fizičkim svojstvima tih materijala te na temelju toga predložiti primjene u različitim tehnologijama, posebno u naprednim. Pri tome je važno uspostaviti odnose između vrste i uvjeta kemijske sinteze te svojstava istraživanog materijala kao što su morfologija i veličina čestica s promjenama u strukturnim, magnetskim i optičkim svojstvima. Cilj predloženih istraživanja je polučiti nova saznanja o kinetici, faznoj transformaciji i mehanizmu nastajanja 1 D a-Fe2O3. Kontroliranim dopiranjem odabranim metalnim ionima, nastojat će se poboljšati optička, magnetska i katalitička svojstva 1D a-Fe2O3. Istraživat će se nanostrukture u području od finih anizotropnih nanočestica do nekoliko stotina mikrometara dugih nanovlakana. Budući da formiranje specifičnih nanostruktura ovisi o brojnim eksperimentalnim parametrima, posebna pažnja će se posvetiti praćenju kinetika te faznim transformacijama tijekom nastajanja nanostruktura a-Fe2O3 upotrebom sofisticiranih strukturnih, mikroskopskih i spektroskopskih instrumentalnih tehnika. Za ostvarenje postavljenih ciljeva predlažu se sljedeća istraživanja: (I) praćenje kinetike i fazne transformacije nastajanja nedopiranih i dopiranih 1D a-Fe2O3 nanostruktura iz koncentriranih ili djelomično neutraliziranih otopina FeCl3, (II) razvoj novih sintetčkih postupaka dobivanja vrlo dugih nedopiranih i dopiranih nanovlakana a-Fe2O3 metodom elektroispredanja i (III) testiranje fotokatalitičke aktivnosti sintetiziranih 1D nanostruktura a-Fe2O3. Osim stjecanja novih temeljnih znanja o 1D nanstrukturiranim materijalima, priredit će se i materijali točno definiranih fizičko-kemijskih svojstava.]]></summary_hr><summary_en><![CDATA[1D (one-dimensional) iron oxides are in the focus of many researchers due to the importance of these materials in fundamental research and their high potential in advanced technologies. The knowledge of relationship  between the chemical and physical properties on one side and the synthesis conditions on the other is extremely important, especially when 1D iron oxides (undoped or doped) with desired properties must be designed. This proposal aims to provide new knowledge about the kinetics, phase transformation and the mechanism of the formation of 1D a-Fe2O3 in dependence of various experimental parameters. In order to pronounce their optical, magnetic and catalytic  properties control doping with selected metal ions will be performed using different experimental approaches. The 1D a-Fe2O3 oxide nanostructures will be investigated in the range from fine anisotropic nanoparticles up to several hundred microns long nanofibers. Since the formation of specific nanostructures is dependent on many experimental parameters a special attention in this proposal will be given to the monitoring of the formation kinetics and phase transformations using sophisticated instrumental techniques such as structural, spectroscopic and microscopic techniques. To achieve the objectives of the proposal the following investigations will be done: (i) monitoring the kinetics, phase transformation and mechanism of the formation of undoped and metal-doped 1D a-Fe2O3 nanostructures from concentrated or partially neutralized FeCl3 solutions, (II) development of new procedures in the formation of very long nanofibers of undoped and metal doped a-Fe2O3 using electrospinning methods and (III) testing the photocatalytic activity of synthesized 1D a-Fe2O3 nanostructures. This proposal is aimed to gain new fundamental knowledge on the formation of 1D nanostructured materials in general, but will also provide the materials with defined physicochemical properties.]]></summary_en></project><project>
<id>4234</id><title_hr><![CDATA[Genetska osnova insekticidnog potencijala dalmatinskog buhača (Tanacetum cinerariifolium /Trevir./ Sch. Bip.)]]></title_hr><title_en><![CDATA[Genetic background of Dalmatian pyrethrum (Tanacetum cinerariifolium /Trevir./ Sch. Bip.) insecticidal potential ]]></title_en><user_id>5513</user_id><user_firstLast_name>Martina Grdiša</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2016-06</proposal_call><code>IP-2016-06-9034</code><acronim><![CDATA[PyrDiv]]></acronim><duration>01.04.2017 - 31.03.2021</duration><status>Završio</status><financ_value>123.133,59 eur</financ_value><scie_area_hr>Biotehničke znanosti, Prirodne znanosti, Tehničke znanosti, </scie_area_hr><scie_area_en>Biotechnical sciences, Natural sciences, Technological sciences, </scie_area_en><scie_field_hr>Poljoprivreda, Biologija, Kemijsko inženjerstvo, </scie_field_hr><scie_field_en>Agriculture, Biology, Chemical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Agronomski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Agriculture]]></institution_en><team_members_id>19538, 7649, 13475, 13692, 770, 4498, 5829, 27500, </team_members_id><team_members_names><![CDATA[Filip Varga, Zlatko Šatović, Marija  Jug-Dujaković, Tonka Ninčević, Zlatko Liber, Martina Periša, Ivan Radosavljević, Nina Jeran, ]]></team_members_names><keywords_hr><![CDATA[biokemijska raznolikost, dalmatinski buhač, disperzija matrice u čvrstoj fazi, genetska raznolikost, insekticid, piretrin, pridruživajuće kartiranje ]]></keywords_hr><keywords_en><![CDATA[Association mapping, biochemical diversity, Dalmatian pyrethrum, genetic diversity, insecticide, MSPD, pyrethrin, Tanacetum cinerariifolium]]></keywords_en><summary_hr><![CDATA[Dalmatinski buhač (Tanacetum cinerariifolium Trevir. /Sch./ Bip.) je stranooplodna, diploidna samoinkopatibilna i termofilna vrsta iz porodice Asteraceae. Endemska je vrsta istočne obale Jadranskog mora a najbrojnije populacije rastu na ekstremno degradiranim staništima  plitkih kamenitih tala. Biljke dalmatinskog buhača tvore prirodni insekticid piretrin, koji je trenutno ekonomski najvažniji insekticid biljnog podrijetla. Uzgoj i upotreba dalmatinskog buhača u hrvatskim kućanstvima i poljoprivrednim sustavima ima dugu tradiciju. Iako ima veliko povijesno i ekonomsko značenje podaci o genetskoj i biokemijskoj raznolikosti prirodnih populacija dalmatinskog buhača gotovo ne postoje. Stoga je značaj predloženog projekta u integraciji različitih znanstvenih područja kako bi se stekla nova saznanja vezana uz biokemijsku i genetsku raznolikost ove endemske i gospodarski važne biljne vrste. Ciljevi projekta su sljedeći: (i) razvitak mikrosatelitnih početnica za dalmatinski buhač, (ii) analiza genetske raznolikosti prirodnih populacija dalmatinskog buhača mikrosatelitnim i AFLP biljezima, (iii) optimizacija metode ekstrakcije disperzijom matrice u čvrstoj fazi i njena primjena u kombinaciji s HPLC-DAD u identifikaciji i kvantifikaciji sadržaja i sastava piretrina istraživanih populacija, (iv) utvrđivanje AFLP biljega vezanih za lokuse povezane sa sintezom pojedinih aktivnih sastavnica piretrina pomoću pridružujućeg kartiranja (Association Mapping) što će olakšati korištenje prirodnih populacija u oplemenjivačkim programima temeljenima na odabiru pomoću biljega (MAS-Marker Assisted Selection). Nove tehnologije i metode predložene u ovom projektu pridonijet će razvoju novih pristupa u praćenju bioraznolikosti i očuvanju biljnih genetskih izvora kao i analizi biokemijskog sastava dalmatinskog buhača. Također, dobiveni će rezultati predstavljati dobar temelj za razvoj budućih oplemenjivačkih programa i uvođenje dalmatinskog buhača u poljoprivrednu proizvodnju.]]></summary_hr><summary_en><![CDATA[Dalmatian pyrethrum (Tanacetum cinerariifolium Trevir. /Sch./ Bip.) is an outcrossing diploid, self-incompatible and thermophytic plant species of the family Asteraceae. It is restricted to the eastern coast of the Adriatic Sea, where it can be found in extremely degraded habitats with shallow rocky soils. It is the source of the most economically important natural insecticide pyrethrin. The cultivation and use of Dalmatian pyrethrum and its products are well documented in Croatian history. Despite its historical significance and economic value limited genetic and biochemical data on Dalmatian pyrethrum is available. Therefore, the importance of this project proposal lies in the integration of various scientific fields in resolving important issues concerning the genetic and biochemical diversity of Dalmatian pyrethrum. The scientific objectives of the project are: (i) development of microsatellite primers (SSR; Simple Sequence Repeats) for Dalmatian pyrethrum; (ii) utilization of newly developed SSR and Amplified Fragment Length Polymorphism (AFLP) markers in assessing genetic diversity of Dalmatian pyrethrum natural populations (iii) optimization of Matric Solid Phase Dispersion (MSPD) technique and its utilization in the extraction of pyrethrins, and identification and determination of six extracted pyrethrin components in sampled populations with High - Performance Liquid Chromatography- DAD (HPLC-DAD), (iv) identification of AFLP markers linked to the trait loci related to the content of each pyrethrin component through Association Mapping studies which will facilitate the management of natural populations in future breeding programmes based on Marker-Assisted Selection (MAS). Emerging technologies and methods proposed in this project will lead to the development of new approaches to biodiversity monitoring, plant genetic resources conservation, future breeding programmes and agricultural exploitation of Dalmatian pyrethrum.]]></summary_en></project><project>
<id>4236</id><title_hr><![CDATA[Proučavanje reperfuzijske ozljede u ljudskom srcu; sprječavanje negativnih aspekata vitalnog terapeutskog postupka]]></title_hr><title_en><![CDATA[Studying Reperfusion Injury in Human Heart; How to Combat Negative Aspects of a Life-saving Therapy]]></title_en><user_id>168</user_id><user_firstLast_name>Marko Ljubković</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2016-06</proposal_call><code>IP-2016-06-6153</code><acronim><![CDATA[REFINE]]></acronim><duration>01.10.2017 - 30.09.2022</duration><status>Završio</status><financ_value>132.722,81 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, Kliničke medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, Clinical sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Splitu, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Split School of Medicine]]></institution_en><team_members_id>599, 19399, 194, 19291, 25252, </team_members_id><team_members_names><![CDATA[Cristijan Bulat, Godfrey L. Smith, Jasna Marinović Ljubković, Martin Bienengraeber, Ivan Mihanović, ]]></team_members_names><keywords_hr><![CDATA[srčana, ljudska, ishemija, reperfuzija, terapija]]></keywords_hr><keywords_en><![CDATA[cardiac, human, ischemia, reperfusion, therapy]]></keywords_en><summary_hr><![CDATA[Smrtnost od kardiovaskularnih bolesti, unatoč unaprijeđenim preventivnim i terapijskim mjerama koje su rezultirale poboljšanim trendovima preživljenja zadnjih godina, još uvijek predstavlja glavni uzrok smrti u svijetu. Ponovna uspostava protoka krvi kroz prethodno začepljene ogranke koronarne arterije je glavni cilj terapeutskog postupka neophodnog u svrhu smanjenja odumiranja srčanog mišićnog tkiva. Međutim, postoji niz dokaza da i sama reperfuzija dijelom dovodi do oštećenja tkiva te da doprinosi sa čak 50% u konačnoj veličini infarkta miokarda. Stoga je veliki broj istraživanja usmjeren pronalaženju postupaka kojima bi se smanjila srčana reperfuzijska ozljeda, od kojih su neki dosegnuli i razinu kliničkih istraživanja. Međutim, rezultati provedenih kliničkih studija su bili mahom negativni, pa je translacija eksperimentalnih podataka, koji su na staničnim i životinjskim modelima bili obećavajući, dosad bila neuspješna. U predloženom projektu planiramo istražiti glavne patološke elemente reperfuzijske ozljede u srčanom tkivu bolesnika s koronarnom bolešću koji će biti podvrgnuti operaciji postavljanja srčane premosnice. Pritom ćemo koristiti suvremene eksperimentalne metode procjene razine slobodnih kisikovih radikala, parametara oštećenja mitohondrija i analize metabolita tijekom ishemije i rane faze reperfuzije, kada je poznato da se većina tkivne ozljede događa. Također planiramo razvoj eksperimentalne platforme koja će omogućiti istraživanje raznih protektivnih postupaka u ljudskom srčanom tkivu, stanicama i mitohondrijima. Svrha predloženog pristupa je omogućiti ispitivanje i translaciju eksperimentalnih rezultata dobivenih temeljnim istraživanjima u kliničku uporabu te u konačnici dati doprinos razvoju terapije reperfuzijske ozljede.]]></summary_hr><summary_en><![CDATA[Mortality due to cardiovascular diseases, despite improved preventive and therapeutic measures that resulted in beneficial trends in the last decades, still remains the main global cause of death. Re-establishment of coronary blood flow following an ischemic period is the main goal of coronary recanalization therapies and is essential for reducing myocardial ischemic damage. However, there is ample evidence that reperfusion itself, besides bringing nutrients and oxygen back to the energy-deprived myocardium, can actually further induce cardiomyocyte death. This reperfusion injury is considered to account up to 50% of the final myocardial damage. Therefore, a great number of research studies focused their efforts on finding various modes of attenuation of the reperfusion injury, with many of them reaching even clinical setting. However, due to negative results of clinical studies, translation of experimental data that showed efficient cardiac protection in cellular and animal models of ischemia-reperfusion has been largely unsuccessful. In the proposed project, we aim to investigate the main culprits of reperfusion injury in myocardial tissue obtained from patients suffering from coronary heart disease and undergoing coronary artery bypass graft (CABG) surgery. We will use state-of-the-art experimental approaches for assessment of free oxygen radicals, mitochondrial damage and metabolomic analysis during ischemia and at the early onset of reperfusion, the time-point which was shown to be responsible for the most of reperfusion injury. Moreover, we propose to develop an experimental platform for investigation of various (potentially) cardioprotective strategies in human cardiac tissue, cells and mitochondria. The purpose of such approach is to bring closer to clinics some of the experimental findings obtained in animal models of the disease and ultimately come closer to reducing the reperfusion injury.]]></summary_en></project><project>
<id>4238</id><title_hr><![CDATA[Filostratigrafija nastanka i gubitka gena]]></title_hr><title_en><![CDATA[Phylostratigraphy of gene gain and loss]]></title_en><user_id>598</user_id><user_firstLast_name>Tomislav Domazet-Lošo</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2016-06</proposal_call><code>IP-2016-06-5924</code><acronim><![CDATA[PhyLoss]]></acronim><duration>01.03.2017 - 30.06.2021</duration><status>Završio</status><financ_value>132.722,81 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Biologija, </scie_field_hr><scie_field_en>Biology, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>1280, 582, 23129, 25015, 25280, </team_members_id><team_members_names><![CDATA[Zeljka Pezer Sakac, Mirjana Domazet-Lošo, Momir Futo, Sara Koska, Nina Čorak, ]]></team_members_names><keywords_hr><![CDATA[filostratigrafija, evolucijska genomika, nastanak gena, gubitak gena, genske obitelji]]></keywords_hr><keywords_en><![CDATA[phylostratigraphy, evolutionary genomics, gene gain, gene loss, gene families]]></keywords_en><summary_hr><![CDATA[Evolucijski životni ciklus gena u genomu pokretan je procesom rađanja i umiranja gena. Mada ovaj mehanizam direktno utječe na sadržaj genoma uzrokujući dobitak i gubitak gena njegova dinamika kroz filogeniju eukariota još je nerazjašnjena. Nastanak i gubitak cijelih genskih obitelji je dodatna razina evolucijskog protoka u genomima koja je česta ali često ignorirana pojava. Za praćenje nastanka i gubitka genskih obitelji moguće je u principu koristiti filostratigrafski pristup. U ovom projektu, predlažemo stvaranje sveobuhvatne i usklađene procjene nastanka i gubitka genskih obitelji kroz filogeniju eukariota koristeći stotine eukariostkih genoma unutar filostratigrafskog okvira. Ovo znanje omogućit će nam procjenu odnosa između stopa nastanka i gubitka genskih obitelji kroz evolucijsko vrijeme i rekonstrukciju sastava genskih obitelji u predačkim genomima. Kako bi ostvarili ove ciljeve razvit ćemo nove algoritme i implementirati nove strategije računanja unutar filostratigrafskog okvira te ćemo ova rješenja učiniti javno dostupna kroz web aplikaciju.  Kada katalog nastanka i gubitka gena bude gotov cilj nam je povezati profile nastanka i nestanka gena s evolucijom fenotipova. Osim evolucijske biologije, naša kolekcija nastanka i gubitka genskih obitelji biti će vrijedan izvor informacija za različita područja uključujući komparativnu genomiku, razvojnu biologiju i translacijsku medicinu. Na primjer, biti će moguće pronaći organizme koji su ‘evolucijski nul-mutanti’ za gene povezane s patološkim promjenama kod čovjeka kao i nove gene povezane s bolestima.Osim direktne koristi od publikacija u vodećim časopisima i znanstvenih suradnji uvjereni smo da će ovaj projekt imati značajan utjecaj na trening mladih znanstvenika koje namjeravamo zaposliti na projektu i osposobiti ih za vođenje istraživanja na presjeku evolucijske i računalne biologije.]]></summary_hr><summary_en><![CDATA[The evolutionary life cycle of genes is powered by the process of gene birth and death. Although this mechanism directly impacts the genome content by generating the gain and loss of genes its dynamics within the phylogeny of eukaryotes is still unclear. The gain and loss of entire gene families is another level of the evolutionary turnover in genomes which is rather frequent but often ignored phenomena. To trace gene family gain and loss one can in principle use phylostratigraphic approach.In this project, we propose to get a comprehensive and synchronized estimate of gene family gain and loss across phylogeny of eukaryotes using hundreds of eukaryotic genomes within the phylostratigraphic framework. This knowledge will allow us to estimate rates of gene family gain and loss relate over evolutionary time, and to reconstruct the ancestral genomes. To achieve these goals we will develop novel algorithms and implement a new computational strategy within the phylostratigraphic framework which will be available as a publicly accessible web resource.   Once the catalogue of gene family gain and loss is complete, we aim to link the gene-and-loss patterns to the evolution of phenotypes. Beside evolutionary biology, our gene gain and loss collection that cover wide range of eukaryotes will provide valuable information for many fields including comparative genomics, developmental biology and translational medicine. For instance it will allow us to look for the organisms that are ‘evolutionary knockouts’ for genes related to human pathologies and to find new candidate genes for diseases.    Beyond the immediate benefits of high impact scientific publications and scientific collaboration we believe that this project will have a profound impact in training young experts that we aim to hire on the project and enabling them to lead the research at the interface between evolutionary and computational biology.]]></summary_en></project><project>
<id>4239</id><title_hr><![CDATA[Novi molekularni mehanizmi kao mete ciljanih terapija: Interakcije molekula mikroRNA i signalnog puta  Hedgehog-GLI u seroznom karcinomu jajnika]]></title_hr><title_en><![CDATA[Novel Molecular Mechanisms for New Therapeutic Approaches: Interactions of microRNAs and Hedgehog-GLI Signaling Pathway in Serous Ovarian Carcinoma]]></title_en><user_id>3089</user_id><user_firstLast_name>Sonja Levanat</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2016-06</proposal_call><code>IP-2016-06-1268</code><acronim><![CDATA[MIRnaGLI]]></acronim><duration>02.05.2017 - 01.05.2019</duration><status>Završio</status><financ_value>66.311,33 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>942, 712, 19584, 1033, 19458, 3488, 19383, </team_members_id><team_members_names><![CDATA[Vesna Musani, Petar Ozretić, Maja Sabol, Diana Trnski, Držislav Kalafatić, Tajana Amšel Zelenika, Hubert Hackl, ]]></team_members_names><keywords_hr><![CDATA[serozni karcinom jajnika, signalni put Hedgehog-GLI, mikroRNA, karcinogeneza, epigenetika, terapija]]></keywords_hr><keywords_en><![CDATA[serous ovarian carcinoma, Hedgehog-GLI signaling pathway, microRNA, carcinogenesis, epigenetics, therapy]]></keywords_en><summary_hr><![CDATA[Serozni karcinom jajnika je gorući klinički problem (visoka smrtnost zbog dijagnoze u poodmakloj fazi bolesti) čija molekularna podloga još nije dovoljno istražena. Naša dosadašnja istraživanja pokazala su promijenjenu aktivnost signalnog puta Hedgehog-GLI (Hh-Gli) u tumorima jajnika koji je normalno aktivan tijekom embriogeneze i u ranom razvoju, dok u odraslom organizmu u tumorima može biti aberantno aktivan. Pokazali smo da aberantna aktivnost tog signalnog puta u karcinomima ovarija nije rezultat ni mutacija niti epigenetskih promjena na razini hipermetilacije promotora najznačajnijih regulatora signalnog puta. Daljnji smjer istraživanja su molekule mikroRNA (miRNA), male nekodirajuće dvolančane molekule RNA, koje imaju ključnu ulogu u post-transkripcijskoj regulaciji genske ekspresije. Naši preliminarni rezultati ukazuju na postojanje povezanosti glavnih komponenti Hh-Gli puta i molekula miRNA. Želimo kroz profile miRNA i genske ekspresije pronaći molekule miRNA karakteristične za serozni karcinom jajnika visokog gradusa. Nadalje,  in vitro i in vivo metodama želimo provesti funkcionalno testiranje interakcija molekula miRNA i njihovih ciljnih gena te utjecaj izmijenjene ekspresije molekula miRNA na fenotip tumorskih stanica. Krajnji cilj projekta je pronaći nove ciljne mete koje bi doprinijele boljoj prognozi, boljim budućim terapijama kao i pojašnjavanju složenih molekularnih interakcija. Naša je hipoteza da promjene u izražaju molekula miRNA vezane uz signalni put Hh-Gli doprinose nastanku seroznog karcinoma jajnika.]]></summary_hr><summary_en><![CDATA[Serous ovarian cancer is urgent clinical problem (high mortality due to diagnosis at an advanced stage of the disease), and its molecular background is still unknown. Our previous studies showed aberrant activity of the Hedgehog-GLI (Hh-Gli) signaling pathway in ovarian tumors, which is normally active only during embryogenesis and early development, while in adults it may be aberrantly active in tumors. We have shown that aberrant activity of this signaling pathway in ovarian cancer is neither the result of mutations nor of promoter hypermethylation of the main pathway regulators. The next to study are microRNAs (miRNAs), small non-coding double-stranded RNA molecules, which have a key role in post-transcriptional regulation of gene expression. Our preliminary results indicate the connection between the main components of the Hh-Gli and miRNA molecules. We intend to combine the results of miRNA and gene profiling to find miRNAs characteristic for high-grade serous ovarian cancer, implement in vitro and in vivo methods to test functional interaction between miRNAs and their target genes and the influence of altered expression of miRNAs on the phenotype of the tumor cells. The ultimate goal of the project is to find new targets that would contribute to a better prediction, better future therapies as well as understanding the complex molecular interactions. Our hypothesis is that changes in the expression of miRNA molecules related to the Hh-Gli signaling pathway contribute to the development of serous ovarian cancer.]]></summary_en></project><project>
<id>4247</id><title_hr><![CDATA[Umrežavanje glazbom: promjene paradigmi u „dugom 19. stoljeću“ – od Luke Sorkočevića do Franje Ks. Kuhača]]></title_hr><title_en><![CDATA[Networking through music: changes of paradigms in the “long 19th century“ – from Luka Sorkočević to Franjo Ks. Kuhač]]></title_en><user_id>7808</user_id><user_firstLast_name>Vjera Katalinić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2016-06</proposal_call><code>IP-2016-06-4476</code><acronim><![CDATA[NETMUS19]]></acronim><duration>01.03.2017 - 31.10.2021</duration><status>Završio</status><financ_value>44.249,78 eur</financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Znanost o umjetnosti, </scie_field_hr><scie_field_en>Arts, </scie_field_en><institution_hr><![CDATA[Hrvatska akademija znanosti i umjetnosti]]></institution_hr><institution_en><![CDATA[Croatian Academy of Sciences and Arts]]></institution_en><team_members_id>19568, 19469, 19726, 19756, 232, </team_members_id><team_members_names><![CDATA[Stanislav Tuksar, Sara Ries, Katja Radoš-Perković, Sanja Majer-Bobetko, Ivana Horbec, ]]></team_members_names><keywords_hr><![CDATA[umrežavanje, glazba, dugo 19. stoljeće, Luka Sorkočević, Franjo Ksaver Kuhač, korespondencija, dnevnik]]></keywords_hr><keywords_en><![CDATA[networking, music, long 19th century, Luka Sorkočević, Franjo Ksaver Kuhač, correspondence, diary]]></keywords_en><summary_hr><![CDATA[Umrežavanje glazbom u „dugom 19. stoljeću“ proučavat će se komparativno na tri tematska kruga: 1) Boravak Luke Sorkočevića (1734-1789) u Beču (1781-82) i njegov dnevnik koji pruža uvid u krug istaknutih političkih, kulturnih i intelektualnih ličnosti i u sustav provođenja politike Dubrovačke Republike; 2) mapiranje dolazaka i nastupa inozemnih putujućih opernih družina i solista u Zagrebu sredinom 19. stoljeća od „prve nacionalne opere“ - Ljubavi i zlobe V. Lisinskoga (1846) do pokretanja stalne nacionalne opere u zagrebu i Zajčeva Mislava (1870); 3) obrazovna i istraživačka povezivanja F. Ks. Kuhača (1834-1911) sa skladateljima, muzikografima i melografima srednje i jugoistočne Europe kroz prizmu korespondencije te objavljene dokumentacije i njegovih radova. Uz arhivska i terenska istraživanja komparativno će se analizirati izvori sačuvani u Hrvatskoj i inozemstvu (Italija, Austrija, Mađarska, Češka, Slovačka, Poljska, Srbija, Bugarska). Istraživanja će rezultirati pojedinačnim člancima i kritičkim izdanjima Sorkočevićeva dnevnika te druge i treće knjige (1864-1872) korespondencije od 13 sačuvanih iz Kuhačeve ostavštine.]]></summary_hr><summary_en><![CDATA[Networking through music in the „long 19th century“ will be comparatively investigated within three thematic areas: 1) The sojourn of Luka Sorkočević (1734-1789) in Vienna in 1781-82 and his diary which gives insight into the circle of outstanding political, cultural and intellectual figures and into the functioning of the politics led by the Dubrovnik Republic; 2) maping of arrivals and performances of foreign itinerant opera companies and soloists in Zagreb in the mid-19th century, from „first national opera“ - Lisinski&#39;s Love and malice (1846) - to the foundation of the permanent opera ensemble in Zagreb and Zajc&#39;s opera Mislav  (1870); 3) educational and research connections of Franjo Ksaver Kuhač (1834-1911) with composers, musicographers and melographers from the central and south-eastern Europe through his correspondence and published documents and his publications. Beside archival and filed research, a comparative analyses of sources preserved in Croatia and abroad (Italy, Austria, Hungary, Czechia, Slovakia, Poland, Serbia, Bulgaria) will be conducted. The research will result with articles and critical editions of Sorkočević&#39;s diary, as well as the second and third book of correspondence (1864-1872) out of 13 preserved in the legacy F. Ks. Kuhač.]]></summary_en></project><project>
<id>4249</id><title_hr><![CDATA[Signalni mehanizmi i metaboličke promjene u diferencijaciji stanica akutne mijeloične leukemije]]></title_hr><title_en><![CDATA[Signaling mechanisms and metabolic changes in differentiation of acute leukemia cells]]></title_en><user_id>4677</user_id><user_firstLast_name>Dora Višnjić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2016-06</proposal_call><code>IP-2016-06-4581</code><acronim><![CDATA[SignalmetabAML]]></acronim><duration>15.04.2017 - 14.09.2021</duration><status>Završio</status><financ_value>132.722,81 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb School of Medicine]]></institution_en><team_members_id>4499, 8442, 4676, 4837, 3497, 19576, 25361, 861749, </team_members_id><team_members_names><![CDATA[Drago Batinić, Antonio  Bedalov, Hrvoje Lalić, Vilma Dembitz, Klara Dubravčić, Josip Batinić, Barbara Tomić, Tomislav Smoljo, ]]></team_members_names><keywords_hr><![CDATA[signaliziranje, AMPK, diferencijacija, ciklus, leukemija]]></keywords_hr><keywords_en><![CDATA[signaling, AMPK, differentiation, cycle, leukemia]]></keywords_en><summary_hr><![CDATA[Akutna mijeloična leukemija (AML) je heterogena skupina bolesti koja je obilježena nekontroliranom proliferacijom blasta koji su zakočeni u ranoj fazi diferencijacije. Najuspješnije farmakološko liječenje AML je diferencijacijsko liječenje pomoću sve-trans-retinske kiseline (ATRA, prema engl. all-trans retinoic acid). Međutim, ATRA se rabi isključivo u liječenju akutne promijelocitne leukemije (APL),  podvrste AML koja sadrži translokaciju t(15;17). Svi ostali oblici AML liječe se intenzivnom kemoterapijom koja nije značajno povećala trajanje remisije ili opće preživljenje. Naše nedavno istraživanje pokazalo je da 5-aminoimidazol-4-karboksamid ribonukleozid (AIKAR, akadezin) potiče apoptozu i pospješuje diferencijaciju staničnih linija AML koje nisu APL, ali je mehanizam djelovanja AIKAR-a još uvijek nepoznat. Stoga je svrha predloženih istraživanja određivanje mehanizama koji su odgovorni za povoljno djelovanje AIKAR-a u stanicama non-APL AML te otkrivanje signalnih mehanizama i metaboličkih promjena koje su odgovorne za monocitnu i granulocitnu diferencijaciju stanica AML. U istraživanju ćemo rabiti komercijalne stanične linije AML da bismo opisali: a) ulogu i mehanizam autofagije u monocitno/makrofagnoj i granulocitnoj diferencijaciji, b) promjene u metabolizmu tijekom diferencijacije i prolaska kroz stanični ciklus, te c) ulogu deacetilaza Sirt u monocitno/makrofagnoj i granulocitnoj diferencijaciji staničnih linija AML. Dodatno, ispitat ćemo učinke AIKAR-a in vitro na uzorcima blasta izoliranih iz oboljelih od AML. Istraživanja signalnih mehanizama odgovornih za diferencirajući učinak u leukemijskim stanicama mogu u konačnici pridonijeti uspješnijem liječenju oboljelih od AML.]]></summary_hr><summary_en><![CDATA[Acute myeloid leukemia (AML) is a heterogeneous group of diseases characterized by clonal proliferation of blasts that are blocked at an early stage of differentiation. The most successful pharmacological therapy of AML is differentiation therapy with all-trans-retinoic acid (ATRA); however, ATRA-based therapy is restricted to acute promyelocytic leukemia (APL), a particular subtype that carries t(15;17) translocation. All other AMLs are treated with intensive chemotherapy, which have not significantly improved the disease-free or overall survival. Our recent study demonstrated that 5-aminoimidazole-4-carboxamide ribonucleoside (AICAR, acadesine) induces apoptosis and enhances differentiation of non-APL AML cell lines, but the mechanism is still unknown. Therefore, proposed studies are aimed to determine the mechanism responsible for beneficial effects of AICAR in non-APL AML cells and to further elucidate signaling mechanisms and metabolic changes responsible for monocytic and granulocytic differentiation of AML cells. We will use commercially available AML cell lines to define: a) the role and the mechanism of autophagy in monocytic/macrophage and granulocytic differentiation, b) the changes in metabolism during differentiation and cell cycle progression, and to determine c) the role of Sirt deacetylase in monocytic/macrophage and granulocytic differentiation of AML cell lines. In addition, in vitro profiling of the sensitivity of primary AML samples to AICAR will be performed. The proposed project aims to define signaling mechanisms responsible for differentiation of leukemia cells, which may eventually lead to the development of an improved therapy, thus contributing to well-being of AML patients.]]></summary_en></project><project>
<id>4250</id><title_hr><![CDATA[Novi biomarkeri kronične bolesti presatka protiv primatelja]]></title_hr><title_en><![CDATA[New biomarkers in chronic Graft-versus-Host disease]]></title_en><user_id>19447</user_id><user_firstLast_name>Dražen Pulanić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2016-06</proposal_call><code>IP-2016-06-8046</code><acronim><![CDATA[Bio-cGVHD]]></acronim><duration>20.03.2017 - 19.03.2021</duration><status>Završio</status><financ_value>132.722,81 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Kliničke medicinske znanosti, Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Clinical sciences, Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb School of Medicine]]></institution_en><team_members_id>4499, 12852, 3334, 19566, 4042, 4959, 12447, 6599, 19410, 4023, 7295, 19615, 19616, 4603, 19652, 19585, 4791, 19939, 19820, 1017, 25404, 25382, 19908, 23225, 4288, 19227, </team_members_id><team_members_names><![CDATA[Drago Batinić, Ervina Bilić, Renata Zadro, Tamara Vukić, Radovan Vrhovac, Lana Desnica, Nadira Durakovic, Zinaida Perić, Lejla Kurić, Marinka  Mravak-Stipetić, Davorka Dušek, Romana  Čeović, Ranka Serventi Seiwerth, Milan Milošević, Damir Nemet, Ernest Bilić, Branimir Anić, Steven Zivko Pavletic, Tajana Klepac Pulanić, Maja Pučić Baković, Maria Radman, Antonela Samardžić, Antonija Babić, Nina Šaban, Vesna Kušec, Ana Zelić Kerep, ]]></team_members_names><keywords_hr><![CDATA[kronična bolest presatka protiv primatelja, biomarkeri, alogena transplantacija krvotvornih matičnih stanica, vWF, faktor VIII, glikani, imunologija]]></keywords_hr><keywords_en><![CDATA[chronic Graft-versus-Host disease, biomarkers, allogeneic hematopoietic stem cell transplantation, vWF, factor VIII, glycans, immunology]]></keywords_en><summary_hr><![CDATA[Kronična bolest presatka protiv primatelja (eng. chronic Graft-versus-Host disease, cGVHD) je multiorganska aloimuna i autoimuna bolest koja je najvažnija kasna komplikacija nakon alogenične presadbe krvotvornih matičnih stanica (aloPKMS) i vodeći uzrok ne-relapsnog morbiditeta i smrtnosti nakon aloPKMS. Zapažena incidencija bolesti kreće se između 30-70% nakon aloPKMS i povećava se zbog sve manjeg peritransplantacijskog mortaliteta, starije dobi transplantiranih bolesnika, češće upotrebe perifernih krvotvornih matičnih stanica i sve većeg broja transplantacija od nesrodnog davatelja. Bolest je kompleksna i obično zahvaća više različitih organskih sustava (kožu, oči, usta, jetru, gastrointestinalni sustav, pluća, muskuloskeletni sustav i genitourinarni sistem), a često se prezentira manifestacijama koje nalikuju na promjene u autoimunosnih bolesti. Nužno je pronalaženje prediktivnih i dijagnostičkih biomarkera koji bi koristili u procjeni rizika nastanka, dijagnoze i praćenja, procjene ativnosti i ishoda kroničnog GVHD. U Kliničkom bolničkom centru Zagreb 2013. godine osnovan je multidisciplinarni tim stručnjaka za cGVHD po uzoru na onaj formiran na National Institutes of Health (NIH, Bethesda, SAD). Osim što doprinosi poboljšanju skrbi za cGVHD pacijente, ovaj tim omogućuje preciznu interdisciplinarnu kliničku i laboratorijsku evaluaciju bolesti, prikupljanje bioloških uzoraka te nudi veliki potencijal za ispitivanje biomarkera ove teške i potencijalno smrtonosne kasne komplikacije nakon aloPKMS.Cilj ovog novog četverogodišnjeg projekta je prospektivnim longitudinalnim istraživanjem ispitati moguće nove biomarkere kroničnog GVHD (analizu glikana, faktora koagulacije, laboratorijskih parametara upale, B limfocita i monocita) uz detaljno kliničko multidisciplinarno evaluiranje bolesnika korištenjem suvremenih NIH standarda za cGVHD. ]]></summary_hr><summary_en><![CDATA[Chronic graft-versus-host disease (cGVHD) is a multi-organ alloimmune and autoimmune disorder and the most important late complication after allogeneic hematopoietic stem cell transplantation (alloHSCT). It is the major cause of non-relapse morbidity and mortality after alloHSCT. Reported incidence rates of cGVHD range from 30-70% of patients after alloHSCT, and are increasing due to lower peritransplant mortality, older recipients, the more frequent use of peripheral blood graft, and more unrelated donors. It is a complex and multisystem disease, affecting skin, eyes, mouth, liver, gastrointestinal tract, lungs,  muscular-skeletal system, and genital tract, often resembling manifestations of various autoimmune diseases. Predictive and diagnostic biomarkers of cGVHD are much needed to predict its onset, diagnose and monitor the disease, prognoses its course and outcome, and characterize its activity. At the University Hospital Center Zagreb a multidisciplinary team for cGVHD was formed in 2013 according to the team from the National Institutes of Health (NIH, Bethesda, USA).  This approach improved care of patients with cGVHD, but also provides interdisciplinary clinical and laboratory evaluation of this disease, collection of biologic samples with great potential for investigation of biomarkers of this complex and potentially lethal late complication after alloHSTC. The goal of this 4-year project is to study possible new biomarkers of cGVHD (glycan analysis, coagulation factors, laboratory markers of inflammation, B lymphocytes and monocytes) in a prospective longitudinal assessment of cGVHD patients, with their detail multidisciplinary evaluations using modern NIH standards for cGVHD.]]></summary_en></project><project>
<id>4251</id><title_hr><![CDATA[Svjetlo na molekulama: istraživanje spregnute elektronske i nuklearne dinamike]]></title_hr><title_en><![CDATA[Light on Molecules: Exploration of Coupled Electron and Nuclear Dynamics]]></title_en><user_id>2848</user_id><user_firstLast_name>Nađa Došlić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2016-06</proposal_call><code>IP-2016-06-1142</code><acronim><![CDATA[LightMol]]></acronim><duration>15.03.2017 - 14.08.2021</duration><status>Završio</status><financ_value>130.731,97 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, Matematika, Fizika, </scie_field_hr><scie_field_en>Chemistry, Mathematics, Physics, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>3692, 19804, 5636, 19686, 2736, 25276, </team_members_id><team_members_names><![CDATA[Marko Tomislav Cvitaš, Piero Decleva, Tomislav Došlić, Davor Davidović, Jurica Novak, Tomislav Piteša, ]]></team_members_names><keywords_hr><![CDATA[neadijabatska dinamika, fotoelektronska spektroskopija, DNA, mikrosolvatacija, višekromoforni sustavi]]></keywords_hr><keywords_en><![CDATA[nonadiabatic dynamics, photoelectron spectroscopy, DNA, microsolvation, multichromophore systems]]></keywords_en><summary_hr><![CDATA[Mogućnost praćenja elektronskih i strukturnih transformacija kroz koje molekulski sustav prolazi nakon apsorpcije svjetla je dugo sanjani san. Njegovo je ostvarenje moguće samo kombinacijom teorijskih i eksperimentalnih istraživanja.  Nove spektroskopijske tehnike temeljene na interakciji s visokofrekventnim zračenjem dopuštaju istraživanje molekulske strukturne dinamike na dosad neviđenoj razini detaljnosti.  Posebno se vremenski razlučena fotoelektronska spektroskopija (TRPES) etablirala kao vodeća tehnika u tom polju. Međutim, interpretacija TRPES eksperimenata zahtijeva naprednu razinu teorije. Teorijske metode za računanje TRPES opservabli moraju biti dovoljno točne da se može uspostaviti izravna veza između strukture molekule i eksperimentalne opservable. One također moraju biti efikasne, jer simulacija vremenski razlučenih eksperimenata zahtijeva račune za stotine ili čak za tisuće molekulskih gemoetrija. Ciljevi ovog projekta su (i) poboljšanje numeričke efikasnosti računanja fotoionizacijskih opservabli. Naš cilj je učiniti vrijeme potrebno za računanje vrlo točnih udarnih presjeka i parametara asimetrije usporedivim s vremenom računanja dinamike u pobuđenim stanjima.;(ii) razvoj metoda za pouzdanije simulacije nedijabatske molekulske dinamike. To se prvenstveno odnosi na uključivanje u simulacije nuklearnih kvantnih efekata. Relaksacija pobuđenih stanja u biomolekulama često odvija  eliminacijom vodika kojeg simulacije neadijabatske dinamike često “ne vide” .(iii) poboljšanje numeričke efikasnost simulacija neadijabatske molekulske dinamike prijenosom dijela računa na grafičke procesore (GPU). To će nam omogućiti istraživanje dinamike složenih  struktura kao što su hidratirane nukleobaze, vertikalno i horizontalno povezane DNA baze.Mišljenja smo da uz korištenje naprednih algoritamskih tehnika ostvarenje sna i nije tako daleko.]]></summary_hr><summary_en><![CDATA[The possibility to follow the electronic and structural transformations that a molecular system undergoes after light absorption is a long-standing dream. The realization of this dream is possible only through a joint theoretical and experimental effort. New spectroscopic techniques based on interaction with high frequency radiation permit the investigation of molecular structural dynamics at an unprecedented level of detail. In particular, time-resolved photoelectron spectroscopy (TRPES) has emerged as the leading technique in this field. However, the interpretation of TRPES experiments requires advanced theory. Theoretical methods for calculating TRPES observables need to be accurate, so that a direct link between the structure of a molecule and the experimental observable can be established. They also need to be efficient because the simulation of time-resolved experiments requires calculations to be performed for hundreds or even thousands of molecular geometries. In order to meet these conditions, which are at the very heart of this project, advances on several fronts will be made: (i) we will improve the numerical efficiency of the computation of photoionization observables. Our goal is to make the numerical effort required for the computation of very accurate cross sections and asymmetry parameters comparable to the one for the computation of the excited state dynamics; (ii) better-quality methods for nonadiabatic molecular dynamics will be developed by the inclusion of nuclear quantum effects in simulations; (iii) we will improve the numerical efficiency of nonadiabatic molecular dynamics simulations by porting part of the calculation to graphical processor units (GPU). This will allow us to explore the dynamics of complex structures such as hydrated nucleobases, stacked and paired DNA bases.We feel that with advanced algorithmic techniques the dream is not so far away.]]></summary_en></project><project>
<id>4261</id><title_hr><![CDATA[Relacijski rodni odnosi u Hrvatskoj: modernizacijske i razvojne perspektive]]></title_hr><title_en><![CDATA[Relational Gender Identities in Croatia: Modernization and Development Perspectives]]></title_en><user_id>7730</user_id><user_firstLast_name>Inga Tomić-Koludrović</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2016-06</proposal_call><code>IP-2016-06-6010</code><acronim><![CDATA[GENMOD]]></acronim><duration>01.04.2017 - 31.08.2021</duration><status>Završio</status><financ_value>79.532,82 eur</financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Sociologija, </scie_field_hr><scie_field_en>Sociology, </scie_field_en><institution_hr><![CDATA[Institut društvenih znanosti Ivo Pilar]]></institution_hr><institution_en><![CDATA[Institute of Social Sciences Ivo Pilar in Zagreb]]></institution_en><team_members_id>7070, 13277, 17800, 19082, 19080, 19604, 6746, 28943, </team_members_id><team_members_names><![CDATA[Jadranka Rebeka Anić, Lynette Šikić Mićanović, Augustin Derado, Mirko Petrić, Ivan Puzek, Željka  Zdravković, Sara Ursic, Filip Užarević, ]]></team_members_names><keywords_hr><![CDATA[muškarci, žene, rodni identitet, modernizacija, razvoj, Hrvatska]]></keywords_hr><keywords_en><![CDATA[men, women, gender identity, modernization, development, Croatia]]></keywords_en><summary_hr><![CDATA[Cilj projekta je istražiti rodne identitete muškaraca i žena u post-tranzicijskoj Hrvatskoj s motrišta novijih teorija modernizacije i teorija razvoja. Predložena tema istražit će se metodološki inovativnim pristupom, koji se temelji na mješovitim metodama i razmatra identitete muškaraca i žena u relacijskom kontekstu. Stavovi, vrijednosti i prakse muškaraca i žena u Hrvatskoj istražit će se anketnim ispitivanjem na nacionalno reprezentativnom uzorku te pomoću 100 polu-strukturiranih intervjua provođenih u kućanstvu i konceptualiziranih kao fokusirane (mikro-) etnografije. Prikupljeni kvantitativni podaci podvrgnut će se faktorskoj i klasterskoj analizi, kao i višestrukoj korespondencijskoj analizi (MCA) i geometrijskoj analizi podataka (GDA). Prikupljeni kvalitativni podaci poslužit će kao osnova za interpretaciju društvene konstrukcije roda unutar specifičnog okruženja (kućanstva) i u širem institucionalnom okruženju povezanom sa svakodnevnim praksama muškaraca i žena.Projekt se temelji na pretpostavci da se modernizacijske i razvojne sposobnosti pojedinog društva mogu procijeniti analizom rodnih odnosa. U svjetlu postavki novijih teorija modernizacije, rodne uloge i rodni odnosi mogu se vidjeti ne samo kao indikatori klasične dihotomije tradicije i modernosti, nego također i individualizacije, refleksivnosti i „samo-poduzetništva“, povezivanih s kontekstom „društva rizika“ u „drugoj moderni“. U tom smislu, njihova analiza omogućuje bogatije i preciznije razumijevanje razvojnih sposobnosti hrvatskog društva od pristupa zasnovanih na „ljudskom kapitalu“, pogotovo s obzirom na to da će istraživanje obuhvatiti i teme povezane s društvenom stratifikacijom i regionalnom diferencijacijom.Ishodi projekta bit će relevantni u kontekstu javnih politika i očekuje se da značajno pridonesu socio-ekonomskom razvoju hrvatskog društva. ]]></summary_hr><summary_en><![CDATA[This project aims to research gender identities of men and women in post-transitional Croatia from the perspectives of new modernization and development theories. It aims to research the proposed subject-matter using an innovative methodological approach based on mixed methods and viewing the gender identities of men and women in a relational context. Attitudes, values and practices of men and women in Croatia will be researched by means of a nationally representative survey but also by means of 100 semi-structured interviews conceptualized as focused (micro-) ethnographies and carried out in the household context. The gathered quantitative data will be subjected to factor and cluster analysis, as well as to multiple correspondence analysis (MCA) and geometric data analysis (GDA). The gathered qualitative data will serve as a basis for interpretation of the social construction of gender within a particular (household) setting and in wider institutional settings related to the everyday practices of men and women.The project is premised on the hypothesis that modernization and development capabilities of a given society can be assessed by means of analysis of gender relations. Set against the tenets of new modernization theories, such an analysis yields the indicators not only of the classical tradition-modernity dichotomy but also of individualization, reflexivity and “self-entrepreneurship” associated with the “risk society” context. In this sense, they offer a richer and more precise understanding of the development capacities of the Croatian society than the “human capital” approaches, especially since the research will also encompass the issues related to social stratification and regional differentiation.The outcomes of the project will be relevant in the public policy context and are expected to contribute significantly to the socio-economic development of the Croatian society.]]></summary_en></project><project>
<id>4263</id><title_hr><![CDATA[Primjena inovativnih metoda u praćenju proteolitičkih, lipolitičkih i oksidativnih procesa tijekom proizvodnje pršuta]]></title_hr><title_en><![CDATA[The application of innovative methods in monitoring of proteolytic, lipolytic and oxidative changes throughout the dry-cured ham process]]></title_en><user_id>19625</user_id><user_firstLast_name>Helga Medić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2016-06</proposal_call><code>IP-2016-06-6793</code><acronim><![CDATA[IM-HQHAM ]]></acronim><duration>01.03.2017 - 28.02.2021</duration><status>Završio</status><financ_value>132.357,82 eur</financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Prehrambena tehnologija, Biotehnologija, </scie_field_hr><scie_field_en>Food technology, Biotechnology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prehrambeno-biotehnološki fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Food Technology and Biotechnology]]></institution_en><team_members_id>19066, 6046, 19976, 19718, 19675, 19702, 25241, 13348, </team_members_id><team_members_names><![CDATA[Kata Galić, Nives Marušić Radovčić, Mia Kurek, Eddy Listeš, Sandra Petričević, Danijel Karolyi, Ivna Poljanec, Mia Brkljača, ]]></team_members_names><keywords_hr><![CDATA[pršut, proteoliza, oksidacija proteina, masena spektrometrija, lipoliza, aroma, senzorska analiza]]></keywords_hr><keywords_en><![CDATA[dry-cured ham, proteolysis, protein oxidation, mass spectrometry, aroma, sensory analysis]]></keywords_en><summary_hr><![CDATA[Primjena novih metoda masene spektrometrije u prehrambenoj tehnologiji omogućuje bolji uvid u biokemijske procese koji se odvijaju tijekom prerade hrane, a njihovi produkti utječu na kvalitetu i nutritivnu vrijednost prehrambenih proizvoda.  S obzirom da su proteini i masti osnovne komponente pršuta, imaju značajan utjecaj na nutritivnu vrijednost, a njihovom razgradnjom tijekom proizvodnog procesa nastaju spojevi odgovorni za teksturu, boju i aromu proizvoda. Znanstveno je utvrđeno da su glavne biokemijske reakcije koje se odvijaju tijekom proizvodnje pršuta proteoliza i lipoliza te su najnovija znanstvena istraživanja u svijetu intenzivno usmjerena na proteolizu i oksidaciju proteina zbog njihovog utjecaja na kvalitetu gotovog proizvoda. Brojni čimbenici koji proizlaze iz tehnološkog procesa proizvodnje utječu na intenzitet proteolitičkih, lipolitičkih i oksidativnih procesa. Stoga je cilj ovog projekta istražiti utjecaj brzine i opsega proteolitičkih, lipolitičkih i oksidativnih procesa na teksturu, boju i aromu finalnog proizvoda, prateći promjene na proteinima i lipidima kroz cijeli proizvodni proces, korištenjem inovativnih analitičkih metoda. Odredit će se  i identificirati proteini, peptidi i amino kiseline kao i proteolitički indeks te oksidacija proteina određivanjem ukupnih proteinskih karbonila. Paralelno s navedenim, odredit će se i oksidacija masti te sastav masnih kiselina, boja, osnovni kemijski sastav, koncentracija NaCl, proteinski i neproteinski dušik te tekstura pršuta. Rezultati ovog projekta pokazat će kako se primjenom novih metoda masene spektrometrije može utvrditi odnos između uvjeta prerade, biokemijskih procesa i teksture pršuta kako bi se osigurala visoka kvaliteta proizvoda. ]]></summary_hr><summary_en><![CDATA[The application of novel mass spectrometry-based methods in food technology provides better insight into the biochemical processes that occur during the processing and their products affect the quality and nutritional value of food. Proteins and fats are major components of dry-cured ham with significant impact on the nutritional value of the product. Through their degradation during the processing arise compounds responsible for the product texture, color and flavor. It has been scientifically established that the main biochemical reactions during the production of dry-cured ham are proteolysis and lipolysis and current scientific research studies are focused intensely on proteolysis and oxidation of proteins because of their impact on the quality of the final product. Numerous factors arising from the technological process influence the intensity of proteolytic, lipolytic and oxidative processes. Therefore, the aim of this project is to investigate the influence of proteolytic, lipolytic and oxidative changes on the texture, color and flavor of the final product by monitoring changes of the proteins and lipids throughout the dry-cured ham process using innovative analytical methods. Proteins will be identified, peptides and amino acids, proteolysis index, the oxidation of proteins and protein carbonyls will be analyzed. In parallel, the oxidation of fat and fatty acid composition, color, basic chemical composition, concentration of NaCl, protein and non-protein nitrogen and texture of the ham will be determined. The results of this project will show that the application of novel mass spectrometry-based methods can help in defining the relationship among processing conditions, the biochemical processes and the texture of dry-cured ham to ensure high quality product.]]></summary_en></project><project>
<id>4267</id><title_hr><![CDATA[Strukturne dekompozicije empirijskih podataka za računalno potpomognutu dijagnostiku bolesti]]></title_hr><title_en><![CDATA[Structured Decompositions of Empirical Data for Computationally-Assisted Diagnoses of Disease]]></title_en><user_id>19111</user_id><user_firstLast_name>Ivica Kopriva</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2016-06</proposal_call><code>IP-2016-06-5235</code><acronim><![CDATA[DEDAD]]></acronim><duration>01.03.2017 - 28.02.2021</duration><status>Završio</status><financ_value>78.890,44 eur</financ_value><scie_area_hr>Tehničke znanosti, Prirodne znanosti, Biomedicina i zdravstvo, </scie_area_hr><scie_area_en>Technological sciences, Natural sciences, Biomedicine and health sciences, </scie_area_en><scie_field_hr>Računarstvo, Matematika, Kemija, Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Computer sciences, Mathematics, Chemistry, Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>3410, 3416, 5103, 715, 1288, 19259, 19142, 19164, 25398, </team_members_id><team_members_names><![CDATA[Marijana  Popović Hadžija, Mirko Hadžija, GORANA ARALICA, Lidija Brkljačić, Marijana Vučić Lovrenčić, Anteja Krištić, Fei Shi, Xinjian Chen, Dario Sitnik, ]]></team_members_names><keywords_hr><![CDATA[faktorizacije, nizak rang, rijetkost, patologija, metaboličko profiliranje ]]></keywords_hr><keywords_en><![CDATA[factorizations, low rank, sparsity, pathology, metabolic profiling]]></keywords_en><summary_hr><![CDATA[Predlaže se razvoj algoritama za dekompozicije empirijskih podataka za računalno potpomognutu dijagnostiku u patologiji, metaboličkom profiliranju dijabetesa II i optičkoj koherentnoj tomografiji oka. Za tu svrhu predlažemo dekompozicije regularizirane niskim rangom, rijetkosti, nenegativnosti i njihovim kombinacijama. Za dobivanje reproducibilnih dekompozicija predlaže se razvoj konveksnih regulariziranih nelinearnih multiplikativnih faktorizacija koje se oslanjaju na samoizražajnost empirijskih podataka. To je nedavno primijenjeno na problem grupiranja u podprostorima (GP). Fokus će biti na: (i) metodama za direktno grupiranje velikih skupova podataka, te (ii) metodama za rješenje GP problema kombinirajući globalno riješenje GP na malom slučajno odabranom trening uzorku sa (ne)linearnom regresijom na ostatku uzoraka. Dobiveni rezultati će se koristiti za validaciju računalno potpomognute dijagnostike na slici histopatoloških preparata. Pri tome će se koristiti prostorno-spektralne značajke izdvojene tenzorskom faktorizacijom temeljenom na Tuckerovom modelu. Za bolje razdvanje koreliranih čistih komponenata predlaže se razvoj algoritama za rijetkosti regulariziranu multiplikativnu faktorizaciju u Hilbertovim prostorima induciranim višetrukim jezgrama. Izdvojene komponente će biti anotirane sa bibliotekom kreiranom na projektu i sastavljenom od oko 400 1H NMR spektara čistih metabolita prisutnih u biofluidima. Razvijene metode će se primjeniti na metaboličko profiliranje i demonstrirati na identifikaciji biomarkera iz 1H NMR spektara humanog urina pozitivnog i negativnog na dijabetes II. Predlaže se kombinacija aditivnih dekompozicija koje poboljšavaju krominanciju i oštrinu slike sa naprednim algoritmima za ukljanjanje šuma u slici. Nova metoda fuzije treba rezultirati poboljšanjem performanse računalno potpomognute dijagnostike. Nadalje, strukturne aditivne dekompozicije će biti primijenjene na sliku optičke koherentne tomografije oka za potiskivanje &#39;&#39;spekla&#39;&#39;. ]]></summary_hr><summary_en><![CDATA[Project goals are related to development of algorithms for structure decompositions of empirical data for computationally assisted diagnosis in pathology, metabolic profiling of diabetes II and optical coherence tomography of an eye. Thus, we propose decompositions regularized by low-rank, sparsity, nonnegativity and their combinations. To achieve reproducible decompositions we propose development of convex regularized nonlinear multiplicative factorization methods that rely on self-expressiveness of empirical data.  That is applied recently for subspace clustering (SC). We shall focus on: (i) methods for direct SC of large scale datasets, and (ii) methods for SC that combine global solution of SC on small randomly selected training samples with (non)linear regression on the rest of the data. Obtained results will be used to validate computer-aided diagnosis using images of histopathological specimens. Thereby, texture-spectral features extracted by Tucker model based tensor factorizations will be used. For better separation of highly correlated pure components we propose derivations of sparsity regularized algorithms for multiplicative factorization in Hilbert spaces induced by multiple kernels. Separated components will be annotated with the library created on a project and compose of 400 1H NMR spectra of pure metavolites known to be present in biofluids. Derived methods will be used for metabolic profiling and demonstrated ob identification of biomarkers from 1H NMR spectra of human urine positive and negative to diabetes II. We propose to combine additive decompositions that enhance chrominance and sharpness of an image with advanced image denoising methods. New fusion method is expected to enhance performance of computer aided diagnosis. Furthermore, structural additive decompositions will be applied to optical coherence tomography image of an eye to suppress speckle. ]]></summary_en></project><project>
<id>4273</id><title_hr><![CDATA[Sustav vjetar-sunce za optimiziranu proizvodnju električne energije u rezidencijalnim objektima]]></title_hr><title_en><![CDATA[Wind-Solar System for Optimized Residential Electric Generation]]></title_en><user_id>11272</user_id><user_firstLast_name>Dinko Vukadinović</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2016-06</proposal_call><code>IP-2016-06-3319</code><acronim><![CDATA[WINDSOR]]></acronim><duration>01.03.2017 - 31.08.2021</duration><status>Završio</status><financ_value>74.882,21 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Elektrotehnika, </scie_field_hr><scie_field_en>Electrical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Splitu, Fakultet elektrotehnike, strojarstva i brodogradnje]]></institution_hr><institution_en><![CDATA[University of Split, Faculty of Electrical Engineering, Mechanical Engineering and Naval Architecture]]></institution_en><team_members_id>12326, 11307, 11280, 22821, 25306, </team_members_id><team_members_names><![CDATA[Cat Ho Nguyen, Duy Nguyen Tien, Mateo Bašić, Ivan Grgić, Matija Bubalo, ]]></team_members_names><keywords_hr><![CDATA[Proizvodnja električne energije, Samouzbudni asinkroni generator, Fotonaponski sustav, Modeliranje, Umjetna inteligencija, Optimizacija]]></keywords_hr><keywords_en><![CDATA[Electric power generation, Self-excited induction generator, Photovoltaic system, Modelling, Artificial Intelligence, Optimization]]></keywords_en><summary_hr><![CDATA[Važna motivacija za izradu predloženog projekta je potreba gradskih područja za zelenom i povoljnom energijom. U okviru ovog istraživačkog projekta razvit će se sustav za optimiziranu proizvodnju električne energije koji kao izvore električne energije sadrži vjetroagregat sa samouzbudnim asinkronim generatorom (SEIG od engl. Self-Excited Induction Generator), fotonaponski sustav i baterije. Predloženi sustav će se istraživati u otočnom režimu rada kao i s priključkom na električnu mrežu.Specifični ciljevi projekta su sljedeći: (i) Razvoj naprednog modela SEIG-a i pripadajućeg sustava vektorske regulacije s vjetroturbinom i trofaznim PWM-upravljanim ispravljačem, koji će uključivati: optimizaciju korisnosti vjetroagregata primjenom neizrazite logike; detekciju brzine vrtnje SEIG-a bez upotrebe mjernog člana; regulaciju napona SEIG-a primjenom naprednog regulatora temeljenog na teoriji algebre granica i genetičkim algoritmima te optimizaciju PWM modulacije ispravljača. (ii) Razvoj izmjenjivača kvazi Z-tipa čiji ulaz čini istosmjerna sabirnica na koju su priključeni PWM-upravljani ispravljač, fotonaponski sustav i baterije, a izlaz se koristi za napajanje trofaznih izmjeničnih trošila ili za priključak na električnu mrežu. Za potrebe sinkronizacije ovog izmjenjivača s električnom mrežom razvit će se novi sustav fazno zatvorene petlje temeljen na teoriji algebre granica i genetičkim algoritmima.(iii) Razvoj simulacijskog modela fotonaponskog sustava koji će uključivati utjecaj osunčanosti fotonaponske ćelije na njenu temperaturu, kapacitet diode fotonaponske ćelije te korekciju uobičajenog izraza za struju zasićenja diode. Za potrebe optimizacije korisnosti fotonaponskog sustava razvit će se algoritam za praćenje točke maksimalne snage, spregnut s regulacijom ulaznog napona izmjenjivača kvazi Z-tipa.Planirano istraživanje će se provesti u suradnji sa znanstvenicima iz Instituta informatičke tehnologije u Hanoju i Fakulteta elektronike u Thai Nguyenu. ]]></summary_hr><summary_en><![CDATA[An important motivation for the proposed project is the need of urban areas for green and affordable energy.Under this research project, a wind-solar system for optimized electric generation will be developed, containing a wind energy conversion system (WECS) with a self-excited induction generator (SEIG), a photovoltaic (PV) system, and batteries as sources of electric power. The proposed system will be investigated in island mode and in grid-connected mode.The specific objectives of the project are as follows:(i) Development of an advanced SEIG model and a corresponding vector control system with a wind turbine and a three-phase PWM-controlled rectifier, which will include the following features: fuzzy-logic-based optimization of the WECS’s efficiency; sensorless detection of the SEIG’s speed; control of the SEIG’s voltage by means of an advanced controller based on the hedge algebra theory and genetic algorithms, and optimization of the rectifier PWM control.(ii) Development of a quasi-Z-source inverter (qZSI) whose input is connected to a DC bus to which the PWM-controlled rectifier, the PV system, and the batteries are also connected, whereas the output of the qZSI is used for supplying three-phase AC loads or for connection to the electric grid. For the purpose of synchronization of the qZSI with the electric grid, a new phase-locked loop will be developed based on the hedge algebra theory and genetic algorithms.(iii) Development of a simulation model of the PV system including the impact of the PV cell irradiance on its temperature, the capacitance of the PV cell diode, and correction of the common term for the diode saturation current. A maximum-power-point-tracking algorithm, coupled with the control of the qZSI’s input voltage, will be developed for optimization of the PV system’s efficiency.The planned research will be carried in collaboration with researchers from the Institute of Information Technology, Hanoi, and Faculty of Electronics, Thai Nguyen.]]></summary_en></project><project>
<id>4276</id><title_hr><![CDATA[Seizmička izolacija osnove građevine s uporabom prirodnih materijala - testiranje s potresnom platformom i numeričko modeliranje]]></title_hr><title_en><![CDATA[Seismic base isolation of a building by using natural materials - shake table testing and numerical modeling]]></title_en><user_id>12821</user_id><user_firstLast_name>Jure Radnić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2016-06</proposal_call><code>IP-2016-06-5325</code><acronim><![CDATA[BASEISOLATION]]></acronim><duration>01.03.2017 - 28.02.2021</duration><status>Završio</status><financ_value>115.203,40 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Građevinarstvo, </scie_field_hr><scie_field_en>Civil engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Splitu Fakultet građevinarstva, arhitekture i geodezije]]></institution_hr><institution_en><![CDATA[University of Split, Faculty of Civil Engineering, Architecture and Geodesy]]></institution_en><team_members_id>19696, 19701, 13117, 13151, 13353, 19464, </team_members_id><team_members_names><![CDATA[Amr Elnashai, M.Atilla Ansal, Domagoj Matešan, Nikola Grgić, Goran Baloevic, Ivan Banović, ]]></team_members_names><keywords_hr><![CDATA[Seizmička izolacija baze, aseizmički sloj, prirodni materijal, kameni oblutci, potresna platforma, numerički model]]></keywords_hr><keywords_en><![CDATA[Seismic base isolation, aseismic layer, natural material, pebbles, shake table, numerical model]]></keywords_en><summary_hr><![CDATA[Primarni cilj projekta je kreiranje i eksperimentalna provjera inovativnog koncepta za smanjenje potresnih sila na niže i srednje visoke građevine pomoću aseizmičkog sloja od prirodnih materijala ispod temelja. Predviđena su dva rješenja takvog sloja. Nakana je da takav koncept bude dostatno efikasan, racionalan i jednostavan za realizaciju, te da nađe svoju široku praktičnu primjenu. Najprije bi se eksperimentalno testirala efikasnost predviđenih aseizmičkih slojeva, varirajući više njihovih tehničko - tehnoloških parametara, s ciljem da se na građevinu prenesu što manja potresna ubrzanja (sile). Prvi aseizmički sloj je predviđen samo iz prirodnih kamenih oblutaka, a drugi od prirodnih kamenih oblutaka u kombinaciji s tankim slojem „kliznog“ materijala. Potom bi se eksperimentalno ispitalo ponašanje zgrada s prethodno navedenim aseizmičkim slojevima pri različitim potresima. Koristio bi se pojednostavljeni umanjeni modeli zgrada koji dobro simuliraju njihove dinamičke karakteristike. Testirala bi se četiri jednostupnjevna modela različite krutosti, simlirajući ponašanje građevina različite krutosti. Isti modeli zgrada bi se testirali i za slučaj bez aseizmičkog sloja, kako bi se mogla provjeriti efikasnost predviđene seizmičke izolacije.Ako bi rezultati istraživanja potvrdili očekivanja, predloženi koncept seizmičke izolacije imao bi slijedeće prednosti u odnosu na uobičajenu seizmičku izolaciju pomoću diskretnih, tehnički složenih i skupih naprava: racionalnost, jednostavnost, trajnost, proširenje tržišta, prihvatljivost za siromašnije zemlje i sl.Jedan od ciljeva projekta je razvoj numeričkog modela za pouzdanu seizmičku analizu ravninskih konstrukcija s predviđenom aseizmičkom izolacijom, kao i prijedlog jednostavnih inženjerskih izraza za proračun kapaciteta posmične nosivosti i deformabilnosti aseizmičkog sloja.Smatra se da bi uspješna realizacija predloženog projekta dala vrijedan doprinos razvoju znanosti i prakse u predmetnom području.]]></summary_hr><summary_en><![CDATA[The primary objective of the project is creation and experimental verification of an innovative concept for reducing seismic forces acting on buildings by using aseismic layer made of natural materials below foundation. Two solutions of such layer are planned. The intention is to make an efficient, rational and easy-to-implement concept, with its wide practical application. First, the effectiveness of the planned aseismic layers would be experimentally tested on the model of a rigid building, by varying several their technical - technological parameters, in order to transfer seismic acceleration (force) on the building as less as possible. The first aseismic layer is predicted as consisted only of natural stone pebbles, and the other of the natural stone pebbles in combination with a thin layer of a &#39;&#39;sliding&#39;&#39; material. Afterwards, the behaviour of real buildings with the above mentioned non-seismic layers would be experimentally tested under different earthquakes. Simplified reduced models of buildings that simulate their dynamic characteristics well would be used. Four one-degree models with different stiffness would be tested. If the results of the study would confirm expectations, the proposed concept of seismic isolation would have the following advantages compared to conventional seismic isolation using discrete, technically complex and expensive systems: rationality, simplicity, sustainability, market expansion, eligibility for poorer countries, etc. One of the objectives of the project is the development of numerical models for reliable seismic analysis of planar structures with the planned seismic isolation, as well as the proposal of simple engineering expressions for the calculation of the shear strength capacity and deformability of the aseismic layer. It is believed that the successful implementation of the proposed project would provide a valuable contribution to the development of science and practice in the concerned area. ]]></summary_en></project><project>
<id>4278</id><title_hr><![CDATA[Lobor - ranosrednjovjekovno središte moći]]></title_hr><title_en><![CDATA[Lobor – an early medieval centre of power]]></title_en><user_id>6829</user_id><user_firstLast_name>Krešimir Filipec</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2016-06</proposal_call><code>IP-2016-06-6622</code><acronim><![CDATA[LearlyCoP]]></acronim><duration>20.03.2017 - 19.08.2021</duration><status>Završio</status><financ_value>75.651,87 eur</financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Arheologija, </scie_field_hr><scie_field_en>Archeology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Filozofski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Humanities and Social Sciences]]></institution_en><team_members_id>12960, 13408, 13158, 12961, 13371, 19885, 5525, 13006, 12780, </team_members_id><team_members_names><![CDATA[Zdravka Hincak, Damir Mihelić, Irena Lazar, Ana Azinović Bebek, Ljubica Tomašek, Paola Iacumin Iacumin, Jana Škrgulja, Ana Mikulka, Petra Nikšić, ]]></team_members_names><keywords_hr><![CDATA[Lobor, rani srednji vijek, središte moći, grobne cjeline, arheologija]]></keywords_hr><keywords_en><![CDATA[Lobor, early middle ages, center of power, grave units, archaeology]]></keywords_en><summary_hr><![CDATA[Vidljiva arheološka kultura, ali i bogatstvo u specifičnom središtu moći, kao što je Lobor u Panoniji, korespondira s onim što donose istraživanja te analiza pripadajućih grobnih cijelina. Interdisciplinarnim istraživačkim metodama na odabranom manjem broju grobnih cjelina (80 do 100), raspoređenih od 500. do 1100. godine ispitat će se mogućnosti arheološke i povijesne interpretacije. Predviđenim istraživanjima na odabranom mikro-lokalitetu (Lobor), namjera je pridonijeti boljem razumijevanju ne samo načina pokopa u Karpatskoj kotlini, time i u srednjoj Europi, u vidu poboljšanja kronologije i metodologije istraživanja grobalja te njihova odnosa prema miljeu u kojem su nastala, već također ispitati krajnje mogućnosti arheoloških i povijesnih izvora za europsku povijest srednjeg vijeka. Istraživanje će doprinjeti rekonstrukciji svakodnevnih kulturnih navika i značajki srednjovjekovne populacije. Projekt je usmjeren na proučavanje povijesnog, kulturološkog i biološkog totaliteta ljudske populacije na određenom prostoru na određenom i jedinstvenom uzorku. Namjera je dobiti cjelovitu sliku svakodnevnih kulturnih navika i obilježja ljudi te odrediti njihove životne i radne uvjete. ]]></summary_hr><summary_en><![CDATA[A clearly discernible archaelogical culture, and the richness of one specific centre of power such as Lobor in Pannonia, corresponds with what the research and analysis of the associated grave ensembles. The possibilities of archaeological and historical interpretation will be examined, through interdisciplinary research methods, on a selected number of grave ensembles (approximately 80 to 100 grave ensembles), dating from 500 to 1000 AD. The planned researches at the selected microlocality (Lobor) are planned to contribute to a better understanding of the manner of burial in the Carpathian Basin, i.e. Central Europe in terms of improving the chronology and the methodology of the research of cemeteries and how they relate to the milieu in which they were created, and also to provide an opportunity to examine the highest possibilities for them to be used as archaeological and historical sources for the medieval history of Europe. The research will contribute to the reconstruction of everyday cultural habits and characteristics of a medieval population. The project aims to study the historical, cultural and biological totality of a human population in a particular area and on a particular and unique sample. The intention is to get a complete picture of everyday cultural habits and characteristics of the people, and to determine their living and working conditions.]]></summary_en></project><project>
<id>4281</id><title_hr><![CDATA[METALOSUPRAMOLEKULSKE STRUKTURE I ANORGANSKO-ORGANSKI POLIOKSOMETALATNI HIBRIDI ]]></title_hr><title_en><![CDATA[METALLOSUPRAMOLECULAR ARCHITECTURES AND INORGANIC-ORGANIC POLYOXOMETALATE BASED HYBRIDES]]></title_en><user_id>134</user_id><user_firstLast_name>Višnja Vrdoljak</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2016-06</proposal_call><code>IP-2016-06-4221</code><acronim><![CDATA[MOLART]]></acronim><duration>01.03.2017 - 30.06.2021</duration><status>Završio</status><financ_value>113.876,17 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, </scie_field_hr><scie_field_en>Chemistry, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>358, 19078, 47, 19084, 3896, 1387, 6825, 57, 634, 5462, 346, 25322, 27400, 27133, </team_members_id><team_members_names><![CDATA[Biserka Prugovečki, Vladimir Damjanović, Marina Cindrić, Danijela Cvijanović, Dubravka Sisak Jung, Jelena Parlov Vuković, Jasna Lovrić, Jana Pisk, Mirta Rubčić, Tomica Hrenar, Ines Primožič, Mirna Mandarić, Dino  Kuzman, Edi Topić, ]]></team_members_names><keywords_hr><![CDATA[metalosupramolekulski spojevi, polioksometalati, hibridi, hidrazoni, dikarboksilati, struktura, biološka svojstva, kvantno kemijski računi]]></keywords_hr><keywords_en><![CDATA[metallosupramolecular compounds, poyoxometalates, hybrides, hydrazones, dicarboxylate, structure, biological properties, quantum chemical calculations]]></keywords_en><summary_hr><![CDATA[Glavna ideja projekta temelji se na principima koordinacijske kemije u dizajnu i sintezi novih MoVI metalosupramolekulskih struktura i organsko-anorganskih hibridnih polioksometalatnih materijala. Sinteza novih spojeva bazirat će se na “bottom-up” pristupu, odnosno njihovoj pripravi iz građevnih blokova nastalih in situ kako u otopini tako i u čvrstom stanju. To će omogućiti ispitivanje procesa samoudruživanja i kristalnog rasta navedenih sustava. Poveznica svih segmenata istraživanja je i u pronalaženju uvjeta neophodnih u kontroli sastava, strukture i svojstava ciljnih spojeva. Očekuje se da će ovo istraživanje dati uvid u mehanizme ispitivanih reakcija i omogućiti tumačenje utjecaja različitih inter- i intramolekulskih interakcija na svojstva višedimenzionalnih sustava ili njihovih građevnih blokova. Metode koje će se koristiti u sintezi organskih, metalosupramolekulskih i anorgansko-organskih polioksometalatnih hibrida bit će modificirane metode otopinske kemije, ali će se koristiti i metodologije zelene kemije. Istraživanja termički induciranih reakcija u čvrstom stanju predstavljaju dodatni izazov ovoga projekta. Predloženi projekt sastoji se od sljedećih dijelova: (i) dizajna i sinteze multifunkcionalnih N,O-donorskih liganada i ispitivanja njihovih svojstava; (ii) sinteze novih MoVI metalosupramolekulskih sustava; (iii) sinteze novih hibridnih organsko-anorganskih polioksometalatnih spojeva; (iv) karakterizacije svih priređenih spojeva; (v) kvantno-kemijskih proračuna i teorijskih tumačenja eksperimentalnih rezultata s ciljem boljeg razumijevanja i poboljšanja ispitivanih procesa; (vi) ispitivanja kemijskih i fizikalnih svojstava priređenih spojeva; (vii) ispitivanja bioloških svojstava odabranih spojeva.]]></summary_hr><summary_en><![CDATA[The main idea of the project is to apply principles of coordination chemistry to design and synthesise new MoVI metallosupramolecular architectures and POM-based organic-inorganic hybrid materials. Such systems will be developed via a bottom-up approach combining suitable building blocks generated in situ in solution as well as in the solid state. The complexity in their construction is an invaluable opportunity to study the self-assembly and crystal growth processes. Links between all segments of this research are in finding suitable conditions that are necessary to control the composition and/or structural features of target architectures. It is expected that our investigation will give insight into particular reaction mechanisms and provide explanation for the influence of different inter- and intramolecular interactions on properties of high-dimensional compounds or their building blocks. Methods used in the synthesis of organic, metallosupramolecular and inorganic-organic hybrids will be modified and performed in accordance to conventional, but also green, chemical methodologies. Investigations of thermally induced reactions in the solid state are additional challenging part of the project. The proposed project consists of the following parts: (i) design and synthesis of multifunctional N,O-donor ligands and study of their properties; (ii) synthesis of novel MoVI metallosupramolecular architectures; (iii) preparation of novel hybrid organic-inorganic compounds based on polyoxomolybdates; (iv) characterisation of all prepared compounds; (v) quantum chemical calculations and theoretical support to the experimental research which will be used to understand and guide the improved efficiency of the studied processes; (vi) investigation of chemical and physical properties of prepared compounds; (vii) investigation of biological properties of selected compounds.]]></summary_en></project><project>
<id>4282</id><title_hr><![CDATA[NRF2 na raskrižju epigenetičkog modeliranja, metabolizma i proliferacije stanice raka]]></title_hr><title_en><![CDATA[NRF2 at the crossroads of epigenetic remodeling, metabolism and proliferation of cancer cells ]]></title_en><user_id>11305</user_id><user_firstLast_name>Koraljka Gall Trošelj</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2016-06</proposal_call><code>IP-2016-06-4404</code><acronim><![CDATA[CrossEMPATICNRF2]]></acronim><duration>15.05.2017 - 14.09.2021</duration><status>Završio</status><financ_value>117.459,69 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, Kliničke medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, Clinical sciences, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>11317, 12333, 5615, 12664, 12721, 12789, 12722, 25296, 25007, 2554, </team_members_id><team_members_names><![CDATA[Renata Novak Kujundžić, Neven Žarković, Ana Čipak Gašparović, Lidija Milković, Božo Krušlin, Young-Joon Surh, Paško Konjevoda, Anamarija Mojzeš, Marko Tomljanović, Nikola Đaković, ]]></team_members_names><keywords_hr><![CDATA[rak, NRF2, epigenetičko modeliranj, metabolizam, proliferacija, kliničko značenje]]></keywords_hr><keywords_en><![CDATA[cancer, NRF2, epigenetic remodeling, metabolism, proliferation, clinical significance]]></keywords_en><summary_hr><![CDATA[NRF2 je čimbenik transkripcije neophodan za aktiviranje mnogih enzima Faze 2 i detoksicirajućih enzima koji su stanici potrebni za funkcionalan antioksidacijski odgovor na stres. U kontekstu kemoprevencije, NRF2 štiti zdravu stanicu od slobodnih radikala i zbog toga je koristan i stanici, i domaćinu. U kontekstu zloćudne bolesti, njegova je aktivnost korisna samo zloćudno promijenjenoj stanici. Najnoviji podaci upućuju na važnost NRF2 u reguliranju transkripcije nekih metaboličkih enzima koji su, izravno ili neizravno, uključeni u nastanak pro-proliferativnog Warburgovog učinka. Na neke se od ovih enzima može vezati kurkumin. Aktivnost NRF2 je regulirana na nekoliko razina. Razina njegove transkripcije ovisi o metiliranosti DNA njegovog promotora (ova su dva parametra negativno korelirana) i postojanju represivne trimetilacijske oznake na lizinu 27 u histonu H3 (H3K27me3). Metiltransferaza histona EZH2, odgovorna za uspostavu ove epigenetske modifikacije smatra se onkoproteinom. Međutim, rezultati studija pokazuju da je njezino ispoljavanje vrlo varijabilno, a prognostička vrijednost kontradiktorna u nekim kliničkim modelima raka (rak pluća). Kako bismo shvatili uzroke ovih razlika, pratit ćemo funkciju NRF2 in vitro, u nekoliko linija stanica raka, u mirovanju i potaknutima gladovanjem i kurkuminom, na razini: a) aktivnosti promotora NRF2; b) prisustvu micro-RNA 200-a i 200-b; c) prisutnosti biljega proliferacije Ki-67; d) prisutnoj aktivnosti dobro znanih gena koje NRF2 izravno potiče (HO-1 i NOQ-1); c) prisustvu enzima koje NRF2 potiče neizravno, a koji su izravno ili neizravno uključeni u nastanak Warburgova učinka (PKM2, SHMT2). Analiza spomenutih proteina bit će, metodom imunohistokemije, napravljena i na arhivskim uzorcima tumora glave i vrata, kako bi se njihova ispoljenost korelirala s biološkim ponašanjem tumora.]]></summary_hr><summary_en><![CDATA[NRF2 is a transcription factor needed to activate Phase II- and detoxifying enzymes which are needed for functional cellular antioxidative stress response. In a chemopreventive setting, NRF2 protects healthy cells from free radicals and is beneficial for the cell and for the host. In the setting of developed malignant disease, its activity is beneficial only for the cancer cell. The most recent data point out its importance in regulating transcription of some metabolic enzymes which are included, directly or indirectly, in the onset of pro-proliferative Warburg&#39;s effect. Some of them were shown to be targets for direct curcumin binding. NRF2 activity is regulated at several levels. Its transcription was shown to be regulated by the level of DNA promoter methylation (which negatively correlates to the level of its transcription) and suppressive trimethylated marks on lysine 27 in histone 3 (H3K27me3). The histone methyltransferase EZH2, which is responsible for establishing this epigenetic modification, is considered to be an oncogene. However, studies have shown that its expression seems to be highly variable, with opposite prognostic values in some clinical cancer models (lung cancer). For understanding these discrepancies, we will follow NRF2 functioning in vitro, in several cancer cell lines, under resting and stimulated (starvation/exposure to curcumin) conditions, at the level of: a) its promoter activity, b) the presence of microRNAs 200-a and 200-b; c) the presence of proliferation marker Ki-67; d) the presence of NRF2 bona fide targets (HO-1 i NOQ-1); c) the presence of enzymes, shown to be indirect NRF2 targets, which are directly or indirectly involved in Warburg&#39;s effect (PKM2, SHMT2). The research will be translated to a clinical setting, through immunohistochemical evaluation of the expression of previously mentioned proteins in archive samples of head and neck tumors to establish a clinical value related to the biological characteristics of the tumor.]]></summary_en></project><project>
<id>4283</id><title_hr><![CDATA[Uloga heterozigotnosti gena za ribosomski protein S6 u zloćudnoj preoprazbi stanica]]></title_hr><title_en><![CDATA[Assessing the oncogenic effects of ribosomal protein S6 heterozygosity]]></title_en><user_id>7705</user_id><user_firstLast_name>Siniša Volarević</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2016-06</proposal_call><code>IP-2016-06-2079</code><acronim><![CDATA[ONCO-RIB]]></acronim><duration>08.05.2017 - 07.10.2021</duration><status>Završio</status><financ_value>132.722,81 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Medicine]]></institution_en><team_members_id>19365, 19452, 19765, 19868, </team_members_id><team_members_names><![CDATA[Slađana  Bursać, Ines Oršolić, Moshe Oren, André Paul Gerber, ]]></team_members_names><keywords_hr><![CDATA[zloćudni tumori, ribosomski protein S6, supresor tumora p53, sinteza ribosoma, jezgrica]]></keywords_hr><keywords_en><![CDATA[cancer, ribosomal protien S6, p53 tumor suppressor, ribosome biogenesis, nucleolus]]></keywords_en><summary_hr><![CDATA[Istraživanja tijekom proteklih desetak godina dokazala su da heterozigotne mutacije specifičnih ribosomskih proteina (RP) uzrokuju patološke promjene u životinjskim pokusnim modelima i nekoliko bolesti u ljudi, uključujući 5q- mijelodisplastični sindrom, anemiju Diamond-Blackfan i brojne vrste zloćudnih tumora. Međutim, molekularni mehanizmi putem kojih heterozigotne mutacije RPs uzrokuju bolesti najvećim dijelom su nepoznati. Proizveli smo genetički modificiranog miša u kojemu se gen za RpS6 može izrezati pomoću rekombinaze Cre. Upotrebom toga životinjskog modela dokazano je da heterozigotnost za RpS6 u stanicama koštane srži uzrokuje patološke promjene koje su slične premalignom sindromu 5q- u ljudi. U pripremi za ovaj projekt HRZZ dokazali smo da heterozigotnost za RpS6 u fibroblastima iz embrija miša (MEF) značajno doprinosi njihovoj zloćudnoj preobrazbi. Temeljem tih rezultata postavljamo hipotezu da heterozigotnost za RpS6 uzrokuje molekularne promjene koje potiču zloćudnu preobrazbu normalnih stanica. Predlažemo sljedeće specifične ciljeve istraživanja koji će omogućiti testiranje te hipoteze:1. Proizvesti MEF-ove u kojima se može uvjetno odstraniti jedan alel gena za RpS6 i gen p53 2. Testirati onkogeni potencijal MEF-ova heterozigotnih za RpS6 3. Odrediti učinak heterozigotnosti za RpS6 gen i gubitka gena p53 na morfološka obilježja jezgrice i njene funkcije, stabilnost genoma, strukturu kromatina i globalnu regulaciju izražaja gena.4. Identificirati mRNA čija je translacija na ribosomima poremećena.Ovaj prijedlog projekta pravovremen je i inovativan. Predloženo istraživanje razjasnit će zagonetku kako sniženi izražaj RP, ključnih sastavnica staničnih strojeva koji omogućuju rast stanice, uzrokuju zloćudne tumore. Osim toga, projekt će unaprijediti istraživački kapacitet, obrazovanje mladih znanstvenika i podići razinu kvalitete istraživanja u Hrvatskoj putem suradnje s vrhunskim svjetskim istraživačima.]]></summary_hr><summary_en><![CDATA[An abundance of evidence from animal models and human disease has shown that inherited and acquired heterozygous mutations of a number of ribosomal proteins can lead to cancer development as well as a variety of other diseases. However, the underlying molecular mechanisms are still largely unknown. We have previously generated a mouse model in which one allele of the RpS6 gene can be conditionally deleted. By employing this model it was shown that RpS6 heterozygosity in bone marrow recapitulates key features of a premalignant condition in humans, the 5q- syndrome. Our preliminary results have shown that RpS6 heterozygous mouse embryonic fibroblasts (MEFs) in the absence of p53 show much greater tumorigenicity than p53 null MEFs, further supporting the view that RpS6 heterozygosity is an oncogenic event. Thus, we hypothesize that RpS6 heterozygosity may lead to molecular alterations that could facilitate malignant transformation. In order to test this hypothesis, we propose the following specific aims:1. Generate conditional MEFs for inducible deletion of one RpS6 allele alone or in combination with p53 gene2. Assess tumorigenic potential of RpS6 heterozygosity3. Determine the impact of RpS6 heterozygosity and p53 loss on nucleolar structure and function, maintenance of genome stability, chromatin structure and global regulation of gene transcription.4. Characterize the mRNA translation landscape of RpS6 heterozygous MEFs.This is innovative and timely proposal. Our studies will elucidate a long standing conundrum, how hypomorphic mutations in RP genes, essential components of the cell’s growth machinery can lead to cancer. The project should positively impact the research capacity, education and science in Croatia via scientific cooperation with world-renowned scientists abroad.]]></summary_en></project><project>
<id>4284</id><title_hr><![CDATA[Frakcionalni analogni i mješoviti sustavi obrade signala]]></title_hr><title_en><![CDATA[Fractional analog and mixed systems for signal processing]]></title_en><user_id>6508</user_id><user_firstLast_name>Dražen Jurišić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2016-06</proposal_call><code>IP-2016-06-1307</code><acronim><![CDATA[FractalAnalogFilters]]></acronim><duration>24.02.2017 - 31.07.2021</duration><status>Završio</status><financ_value>102.063,84 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Elektrotehnika, </scie_field_hr><scie_field_en>Electrical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id>1391, 13521, 7457, 3773, 21276, 19032, 24356, </team_members_id><team_members_names><![CDATA[Vesna Županović, Boško Mrković, Neven Mijat, Domagoj Vlah, Edi Emanović, Marko Šprem, Tomislav Jelkovic, ]]></team_members_names><keywords_hr><![CDATA[Analogni i mješoviti krugovi, Aktivni električni filtri, Analogno sučelje, Cadence, PSpice]]></keywords_hr><keywords_en><![CDATA[Analog and mixed circuits, Active electrical filters, Analog front end,  Cadence, PSpice]]></keywords_en><summary_hr><![CDATA[U predloženom projektu će se istraživati nove metode projektiranja vremenski kontinuiranih aktivnih analognih filtara necjelobrojnog (frakcionalnog) reda za analogno sučelje u komunikacijskim sustavima. Do sada su takvi sustavi bili cjelobrojnog reda, a u ovom projektu će se izvršiti poopćavanje na necjelobrojni red. U najnovijim publikacijama dokazano je da su takve metode poželjne, ali u mnogim primjenama postoje ograničenja zbog izvedivosti frakcionalnih komponenata koji nisu još u komercijalnoj uporabi. Osim problema u proizvodnji frakcionalnih komponenata postoje i neriješeni matematički problemi kao što su analiza osjetljivosti, šuma, te stabilnosti necjelobrojnih sustava. U integriranoj realizaciji se ti problemi posebno uočavaju (visoke osjetljivosti na tolerancije komponenata, nestabilnost zbog parazita) i pozivaju na nove, nekonvencionalne i kreativne tehnike realizacije. Posebno ćemo se u istraživanju usredotočiti na analogni dio mješovitih elektroničkih sklopova, kao dio &#39;analognog sučelja&#39; prema vanjskom analognom svijetu. Pokazati ćemo da se primjenom teorije električnih krugova i linija mogu postići razna predložena poboljšanja. Istraživanja u početku će biti cjelobrojna, a zatim ćemo se koristiti frakcionalnim računom kako bi dobili što veću fleksibilnost i dodatni stupanj slobode u projektiranju. Pomoću teorije fraktala predložiti ćemo novu Besselovu filtarsku aproksimaciju. Kao rezultat projekta, uz navedena nova teoretska dostignuća, dva integrirana kruga koja služe za verifikaciju teorije, realizirat će se u tipičnoj CMOS 0,18um ili 0,35um tehnologiji za koju imamo podršku na FER-u. Ovaj projekt je važan jer unaprjeđuje analogne električne filtre, koji su kasnili u razvoju. Projekt također nudi mogućnost znanstvenog usavršavanja mladih znanstvenika u Hrvatskoj, jer su doktorski studenti i postdoktorski istraživači predviđeni kao suradnici na projektu.  Također je primjenjiv u industriji.]]></summary_hr><summary_en><![CDATA[The proposed project will explore new methods for design of continuous time analog filters of non-integer (fractional) order for analog interface in communication systems. Until now, such systems were of integer order, and in this project the generalization to the non-integer order will be done. In recent publications it has been proven that such methods are desirable, but in many applications, there are limitations due to the feasibility of fractional components that are not yet in commercial use. In addition to the problems in the production of fractional components there are unsolved mathematical problems such as sensitivity analysis, noise and stability of non-integer systems. In the integrated implementation these problems are especially observed (high sensitivity to components tolerances, instability due to parasitic components) and are calling for new, unconventional and creative techniques of realization. In particular we will focus our research on analog part of mixed electronic circuits, which is a part of the &#39;analog interface&#39; to the outside analog world. We will show that the application of the theory of electrical circuits and lines can achieve a variety of proposed improvements. Research in the beginning will be of integer order, and afterwards fractional for high flexibility and additional degree of design freedom. Using the theory of fractals we propose a new Bessel filter approximation. As a result of the project, with new theoretical achievements, two integrated circuits that are used for verification of the theory will be realized in a typical CMOS 0,18um or 0,35um technology for which we have the support of the FER. This project is important because it improves the analog electrical filters that were late in development. The project also offers the possibility of training young scientists in Croatia, because they are predicted as collaborators on this project as doctoral students and postdoctoral researchers. It is applicable for industry, too.]]></summary_en></project><project>
<id>4286</id><title_hr><![CDATA[Modeliranje mentalne gramatike hrvatskoga: ograničenja informacijske strukture]]></title_hr><title_en><![CDATA[The Building Blocks of Croatian Mental Grammar: Constraints of Information Structure]]></title_en><user_id>12893</user_id><user_firstLast_name>Anita Peti-Stantić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2016-06</proposal_call><code>IP-2016-06-1210</code><acronim><![CDATA[MEGAHR/MEGACRO]]></acronim><duration>10.03.2017 - 09.10.2021</duration><status>Završio</status><financ_value>73.793,88 eur</financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Filologija, </scie_field_hr><scie_field_en>Philology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Filozofski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Humanities and Social Sciences]]></institution_en><team_members_id>3451, 12761, 4516, 7143, 7769, 19536, 6644, 24278, 25299, </team_members_id><team_members_names><![CDATA[Mateusz-Milan Stanojević, Jelena Tušek, Mirjana Tonković, Nikola Ljubešić, Gordana Keresteš, Jana Willer-Gold, Maja Anđel, Irina Masnikosa, Vedrana Gnjidić, ]]></team_members_names><keywords_hr><![CDATA[mentalna gramatika, informacijska struktura, računalno modeliranje, psiholingvistika, paralelna arhitektura, jezična kompetencija]]></keywords_hr><keywords_en><![CDATA[mental grammar, information structure, computational modeling, psycholinguistics, parallel architecture, language competence]]></keywords_en><summary_hr><![CDATA[Osnovni je cilj projekta Modeliranje mentalne gramatike hrvatskoga: ograničenja informacijske strukture odrediti gradivne sastavnice informacijske strukture mentalne gramatike hrvatskoga. Na temelju korpusnog i psiholingvističkog pristupa istražit ćemo načine procesiranja morfosintaktičkoga i semantičkoga slaganja konkretnih i/ili apstraktnih leksičkih jedinica u koordiniranim i eliptičnim strukturama, kao i načine procesiranja informacijske strukture rečenice s obzirom na smještaj klitika. Na temelju toga ćemo odrediti skup nužnih, univerzalnih kao i jezičnospecifičnih obrazaca koji određuju informacijsku strukturu hrvatskoga, na morfosintaktničkoj i na semantičkoj razini. Usredotočit ćemo se na lokalna (linearna) i globalna (hijerarhijska) ograničenja procesiranja u mentalnoj gramatici hrvatskoga. Teorijske posljedice takvoga pristupa vidjet će se u mogućnosti razvijanja modela jezičnoga procesiranja, kao i za određivanje i uspostavljanje veza između globalnih i lokalnih gradivnih elemenata mentalne gramatike hrvatskoga. Na praktičnoj će razini projekt kroz kurikularnu obnovu pridonijeti poboljšanju produktivne jezične kompetencije u okvirima obrazovnog sustava. Kako bismo ostvarili ove ciljeve, provest ćemo tri vrste aktivnosti: 1) na temelju korpusa hrWaC uspostavit ćemo korelaciju između kategorija konkretnosti i predočivosti za 3000 leksičkih jedinica kao i za skup gramatičkih jedinica (zamjeničkih i glagolskih klitika); 2) uspostavit ćemo odnos između konretnosti i slaganja (s obzirom na rod, elipsu i smještaj klitika); 3) odredit ćemo specifične obrascie potrebne za izgradnju komunikacijski učinkovitih mreža riječi i gramatičkih struktura u hrvatskom obrazovnom sustavu.Metodološka inovativnost istraživanja ogleda se u povezivanju teorijski informiranog kvalitativnog i kvantitativnog psiholingvistički relevantnog istraživanja koje će omogućiti uspostavu prediktivne leksičke analize na razini korpusa, kao i na razini gramatičkih obrazaca mentalne gramatike.]]></summary_hr><summary_en><![CDATA[The goal of the project The Building Blocks of Croatian Mental Grammar: Constraints of Information Structure is to determine the building blocks of the information structure of Croatian mental grammar. Specifically, based on corpus and psycholinguistic research, we will look into how speakers process morphosyntactic and semantic agreement of concrete and/or abstract lexical items in coordinated constructions and elliptical conditions, as well as how they process sentence information structure with regard to complex clitic cluster positioning. Thus, we will determine a set of necessary, universal and language-specific patterns that represent the requirements determining the information structure in Croatian, both on the morphosyntactic and the semantic level. We are predominantly interested in local (linear) and global (hierarchical) processing constraints within the mental grammar of Croatian. Our approach will have theoretical consequences for developing a model of language processing, as well as identifying and correlating global and local building blocks of mental grammar of Croatian. On the practical level, we seek to improve the productive linguistic competence of pupils in the education system. This will be operationalized through three main activities: (1) psycholinguistically establishing a correlation between concreteness and imageability for a set of high and low frequency lexical and grammatical items (clitics) based on corpus data; (2) psycholinguistically establishing the relationship between concreteness and agreement (in gender, ellipsis and clitic cluster positioning); (3) establishing language-specific patterns for building effective word and grammar webs within the educational system. Methodological novelty is reflected in connecting a theoretically-based qualitative and quantitative psycholinguistic research with a corpus study, which will enable the establishment of a predictive lexical analysis, as well as grammatical patterns in mental grammar.]]></summary_en></project><project>
<id>4287</id><title_hr><![CDATA[Kolektivni efekti, tunelirajući i topološki transport u novim nanospojevima]]></title_hr><title_en><![CDATA[Collective effects, tunnelling and topological transport in novel nanojunctions]]></title_en><user_id>6910</user_id><user_firstLast_name>Danko Radić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2016-06</proposal_call><code>IP-2016-06-2289</code><acronim><![CDATA[C3TiNN]]></acronim><duration>15.03.2017 - 14.03.2022</duration><status>Završio</status><financ_value>126.318,93 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, </scie_field_hr><scie_field_en>Physics, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>13440, 2752, 19805, 25070, 4962, 864989, </team_members_id><team_members_names><![CDATA[Anatoliy Kadygrobov, Emil Tafra, Nina Marković, Petra Grozić, Zoran Rukelj, Barbara Keran, ]]></team_members_names><keywords_hr><![CDATA[magnetsko polje, magnetski proboj, sintetičko baždarno polje, val gustoće, kvantne oscilacije, NEMS, tunelirajući transport, topološki transport]]></keywords_hr><keywords_en><![CDATA[magnetic field, magnetic breakdown, synthetic gauge field, density wave, quantum oscillations, NEMS, tunneling transport, topological transport]]></keywords_en><summary_hr><![CDATA[Prvi cilj ovog projekta je formulirati teorijski pristup za istraživanje novih značajki pod utjecajem magnetskog polja i drugih baždarnih polja, induciranim npr. deformacijom rešetke, na kolektivna, strukturna, magnetotransportna i elektromehanička svojstava materijala reducirane dimenzije, odnosno 2D i kvazi-2D sustava poput grafena, spojeva baziranih na grafenu i nekih hi-Tc kuprata. Želimo istražiti posebnu ulogu magnetskog proboja u grafenu i sličnim sustavima u kojima elektron-elektron interakcija nije naglašena &#39;&#39;ugnježđenjem&#39;&#39; Fermijeve plohe. Također, u posebnom fokusu je jedinstveno svojstvo grafenskog sustava s Dirakovskom elektronskom disperzijom: nastank snažnih pseudomagnetskih polja zbog mehaničke deformacije rešetke. Naše preliminarne estimacije ukazuju mogućnost nastanka novog tipa osnovnog stanja - val gustoće induciran magnetskim probojem zbog sinttičkog magnetskog polja što možda objašnjava opaženi vala gustoće naboja u interkaliranom grafitu CaC6. Također, želimo istražiti pojavu kvantnih oscilacija u magnetotransportu, fundamentalno utjecanih magnetskim probojem, opaženih u grafenskim sustavima i hi-Tc kupratima. Nadalje, istražit ćemo nanoelektromehanički sustav baziran na grafenu i &#39;&#39;spin-gate&#39;&#39; mehanizmu u cilju nalaženja parametarskog prostora za nastanak samo-ekscitiranih oscilacija zbog magnetomotornog vezanja elektronskog i mehaničkog podsustava uz poseban fokus na ulogu sintetičkih polja. Drugi cilj je eksperimentalna realizacija tj. dizajn i fabrikacija uređaja na nanoskali koji se temelji na spinskim efektima induciranim magnetskim poljem. Također, istražit ćemo nova kolektivna stanja kombiniranjem materijala s različitim parametrima uređenja ili topološki zaštićenim stanjima. Pored fabrikacije obavit ćemo mjerenje kompletne magnetotransportne karakteristike.]]></summary_hr><summary_en><![CDATA[The first goal of this project is to formulate a theoretical approach for novel features under influence of magnetic field and other gauge fields, introduced by e.g. deformation of the lattice, on collective, structural, magneto-transport and electromechanical properties of materials with reduced dimension, namely of 2D and quasi-2D systems like graphene, graphene-based compounds and some high-Tc cuprates. We want to address the special role of magnetic breakdown to collective properties in the graphene-like systems in which electron-electron interaction is not enhanced by the &#39;&#39;nesting&#39;&#39; of the Fermi surface. Also we put a special focus on unique feature of grapehene-like system with Dirac-like electron dispersion: the onset of strong pseudomagnetic fields due to mechanical deformation of lattice. Our preliminary estimations indicate the possibility of new type of ground state - magnetic breakdown-induced density wave, driven by the synthetic magnetic field, possibly explaining the recently observed charge density wave in intercalated graphite CaC6. Also, we want to address the onset of quantum oscillations in magnetotransport, also fundamentally influenced by magnetic breakdown, observed in graphene-based systems and high-Tc cuprates. Furthermore, the graphene-based nanoelectromechanical systems based on spin-gate mechanism will be investigated in order to find parameter space for onset of self-excited oscillations due to magnetomotive coupling of electronic and mechanical subsystem with special focus on the role od synthetic fields. The second goal is experimental realization i.e. design and fabrication of nanoscale devices that utilize and investigate the magnetic field-driven spin-dependent phenomena. We will also explore creating novel collective states by combining materials with different order parameters or topologically protected states. Besides fabrication the complete magnetotransport characteristic will be measured.]]></summary_en></project><project>
<id>4290</id><title_hr><![CDATA[Molekularni biljezi vulnerabilnosti, adaptacije i plastičnosti neurona u akutnoj i kroničnoj ozljedi mozga]]></title_hr><title_en><![CDATA[Molecular markers of neuronal vulnerability, adaptation and plasticity in acute and chronic brain lesion]]></title_en><user_id>12600</user_id><user_firstLast_name>Svjetlana Kalanj Bognar</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2016-06</proposal_call><code>IP-2016-06-8636</code><acronim><![CDATA[NeuroReact]]></acronim><duration>01.06.2017 - 31.03.2022</duration><status>Završio</status><financ_value>127.473,62 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo, Prirodne znanosti, </scie_area_hr><scie_area_en>Biomedicine and health sciences, Natural sciences, </scie_area_en><scie_field_hr>Temeljne medicinske znanosti, Kemija, Biologija, Kliničke medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, Chemistry, Biology, Clinical sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb School of Medicine]]></institution_en><team_members_id>12492, 13292, 13131, 5255, 7088, 19823, 19405, 7574, 19043, 19532, 23338, 26530, </team_members_id><team_members_names><![CDATA[Kristina Mlinac Jerković, Željka Vukelić, Dragana Fabris, Aleksandra Dugandžić, Pero Hrabač, Ivana  Rosenzweig, Rodrigo Herrera Molina, Tomislav Sajko, Katarina Ilić, Zamfir Alina, Mario Stojanović, Borna Puljko, ]]></team_members_names><keywords_hr><![CDATA[selektivna vulnerabilnost neurona, hipokampus, mali mozak, glikolipidom, plastičnost, neurodegeneracija]]></keywords_hr><keywords_en><![CDATA[selective neuronal vulnerability, hippocampus, cerebellum, glycolipidome, plasticity, neurodegeneration]]></keywords_en><summary_hr><![CDATA[Više od 165 milijuna ljudi u Europi boluje od poremećaja koji zahvaćaju živčani sustav. Izrazito opterećenje za bolesnika i zdravstveni sustav predstavljaju bolesti kojima je zajednička neurodegeneracija. Neuroni pokazuju selektivnu vulnerabilnost, a intrigantna je razlika u odgovoru na raznovrsne nokse između velikog i malog mozga. Naša je hipoteza da različiti tipovi stanica u mozgu sadrže prepoznatljiv molekularni „potpis“ koji ih čini više ili manje osjetljivima i koji sudjeluje u odgovoru na patološki proces. Cilj projekta je utvrditi u kolikoj mjeri su za selektivnu vulnerabilnost neurona odgovorni zajednički učinci ekspresije određenih proteina i njihovog lipidnog miljea, odnosno postoje li specifične promjene sastava i ekspresije membranskih glikolipida i proteina koje se mogu povezati s patogenezom neurodegeneracije u stanjima akutne i kronične ozljede mozga. Fokusirat ćemo se na analizu neurona hipokampusa i malog mozga u stanjima hiperekscitabilnosti, hipoksične lezije i Alzheimerovoj bolesti. U istraživanju će biti korišteni ljudski uzorci, tkivo mišjih modela i stanični model, čiji će specifični glikolipidomski profili biti povezani s rezultatima transkriptomske, proteomske, elektrofiziološke i morfološke analize. Projekt je nastavak naših istraživanja koja su dokazala: promjene sastava i metabolizma gangliozida u Alzheimerovoj bolesti u mozgu i perifernim tkivima; utjecaj sastava moždanih gangliozida na ekspresiju membranskih proteina uključenih u sinaptičku plastičnost i transport iona, u mišjem modelu čijim fenotipom dominira degeneracija aksona i sklonost konvulzijama. U ovoj studiji ćemo usporediti ekspresiju glikolipida i izabranih proteina u dvije regije mozga s različitim odgovorom na neurodegeneraciju, stoga očekujemo da će istraživanje olakšati prepoznavanje specifičnih molekularnih biljega vulnerabilnosti i adaptacije neurona. Hipotetski je moguće modulirati aktivnost molekula-biljega i pospješiti funkcionalnu prilagodbu tkiva na ozljedu.  ]]></summary_hr><summary_en><![CDATA[Nervous system disorders affect more than 165 million people in Europe. Diseases sharing neurodegeneration as a common pathological feature present a particularly big burden for patients and public health. Neurons are selectively vulnerable and there is intriguing difference between cerebral and cerebellar neurons responding to pathological stimuli. We hypothesize that different neuronal types contain recognizable molecular “signature” making them more or less susceptible and which is involved in tissue response to lesion. The aim of the project is to estimate combined effects of specific membrane proteins expression and their lipid environment on selective neuronal vulnerability, i.e. to determine whether specific changes in membrane glycolipid and protein composition and expression may be related to neurodegenerative pathogenic events. We will focus on the analysis of hippocampal and cerebellar neurons affected by hyperexcitability, hypoxia and Alzheimer’s disease. Glycolipidomic profile of selected regions derived from human and mouse models brain and cellular model will be associated with results of detailed transcriptomic, proteomic, electrophysiological and morphological analysis. Project is based on our previous research showing: changes of ganglioside composition and metabolism in brain and peripheral tissues in Alzheimer’s disease; influence of brain ganglioside composition on expression of membrane proteins involved in synaptic plasticity and ion transport in mouse model with phenotype characterized by axonal degeneration and susceptibility to convulsions. In this study, we will compare the expression of glycolipids and selected proteins in two brain regions responding/reacting differently to neurodegeneration. We expect that such an approach will enable recognition of specific molecular markers of neuronal vulnerability and adaptation. Hypothetically, modulating the activity of these molecular markers may contribute to functional tissue adaptation.]]></summary_en></project><project>
<id>4294</id><title_hr><![CDATA[Fizika mnogočestičnih sustava - iskorištavanje svijeta kompleksnosti]]></title_hr><title_en><![CDATA[The physics of many body systems – exploiting the world of complexity]]></title_en><user_id>4336</user_id><user_firstLast_name>Osor  Slaven Barišić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2016-06</proposal_call><code>IP-2016-06-7258</code><acronim><![CDATA[COMPLEX_ORBIS]]></acronim><duration>01.03.2017 - 31.10.2021</duration><status>Završio</status><financ_value>126.326,38 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, </scie_field_hr><scie_field_en>Physics, </scie_field_en><institution_hr><![CDATA[Institut za fiziku]]></institution_hr><institution_en><![CDATA[Institute of Physics in Zagreb]]></institution_en><team_members_id>3457, 4814, 6532, 4380, 25109, 25108, 28808, 855336, 855341, </team_members_id><team_members_names><![CDATA[Katarina Uzelac, Zvonko Glumac, Ivan Balog, Eduard  Tutiš, Yuki Utsumi Boucher, Juraj Krsnik, Naveen Singh  Dhami, Sudhakar  Pandey, Lucija Nora Farkaš, ]]></team_members_names><keywords_hr><![CDATA[jaka međudjelovanja, nered, neravnotežna dinamika, kompleksni sustavi, izranjajuće pojave]]></keywords_hr><keywords_en><![CDATA[strong interactions, disorder, nonequlibrium dynamics, complex systems, emerging phenomena]]></keywords_en><summary_hr><![CDATA[Kompleksni sustavi karakterizirani su izranjajućim pojavama koje se u hijerarhiji skala pojavljuju vrlo daleko od onih skala koje karakteriziraju međuodnose između pojedinačnih sastavnica tih sustava. Zato takve pojave, vrlo različitih uzroka, konstantno privlače pažnju znanstvene zajednice. Bez obzira na inherentnu raznolikost, različite teme vezane za fiziku kompleksnih sustava dijele neke zajedničke koncepte i principe. Razumijevanje takvog fizikalnog bogatstva zahtijeva razvoj integrativnog teorijskog pristupa, sposobnog  tretirati probleme istovremeno preko različitih polja istraživanja. Osnovna ideja ovoga projekta je ostvarivanje široke strategije istraživanja, birajući probleme koji su izrazito aktualni unutar međunarodnih istraživanja, uz istovremeno održavanje bliske veze s eksperimentalnim rezultatima.Projekt se bavi izranjajućim pojavama u mnogočestičnim sustavima karakteriziranim jakim međudjelovanjem, neredom i/ili izvanravnotežnim stanjem. Predmeti predloženog istraživanja kreću se od specifičnih materijala od posebnog interesa u polju kondenzirane materije, do bioloških sustava, čije se funkcije u prirodnom okruženju u pravilu ostvaruju u izvanravnotežnim stanjima. Projekt je organiziran u tri radna paketa (WP), pri čemu se svaki od njih usredotočuje na jednu od klasa mnogočestičnih sustava u kojima se opažaju izranjajuće pojave. To su sustavi s jakim međudjelovanja, sustavi s neredom i sustavi izvan ravnoteže. Svaki WP je organiziran je u različite zadaće, koje iako su specifične za određeni WP dijele ujedno i značajan stupanj komplementarnosti, osiguravajući koherentnost i međupovezanost između WP-ova.Osim specifičnih znanstvenih doprinosa, namjera projekta je omogućiti i značajnu konsolidaciju teorijskih istraživanja na Institutu za fiziku, uključujući poboljšano okruženje za mlade istraživače. Podrška HrZZ-a projektu je stoga od ključne važnosti za održanje međunarodne kompetitivnosti članova tima, kao i za otvaranje novih perspektiva. ]]></summary_hr><summary_en><![CDATA[Complex systems are characterized by phenomena emerging in the hierarchy of scales far from those describing the numerous individual components. Such phenomena, which have a variety of origins, have repeatedly attracted the attention of the scientific community. Irrespective of the inherent diversity, some common concepts and principles are shared across different topics. Uncovering and understanding this richness requires the development of an integrative theoretical approach, capable of dealing with many-body problems across different fields. In this light, the main purpose of the present project is to enforce such a broad strategy by choosing problems that are highly relevant in current international research endeavors, while simultaneously maintaining a close connection with experimental results.The project addresses phenomena that emerge in systems characterized by strong interactions, disorder and/or the absence of equilibrium. The objects of the proposed research range from specific materials, the investigation of which is on the forefront of condensed matter research, to biological systems, functioning in their natural environment as physical systems far from equilibrium. The project is organized into work packages (WPs), each of which focuses on one important aspect of many-body systems exhibiting emergent phenomena. These are strong interactions, disorder and out-of-equilibrium dynamics. Each WP is organized around a series of different tasks, which, while WP-specific, share a significant degree of complementarity, ensuring coherence and interconnectedness across the WPs. Besides specific scientific contributions, the project aims to provide a significant consolidation of theoretical investigations at the Institute of Physics, including an improved environment for young researchers. The HrZZ’s support of the project is therefore of crucial importance for maintaining the international competitiveness of team members and for future perspectives.]]></summary_en></project><project>
<id>4299</id><title_hr><![CDATA[Geološki i seizmološki aspekti geodinamike Kvarnera - razotkrivanje kvarnerskog rasjeda]]></title_hr><title_en><![CDATA[Geological and seismological aspects of geodynamics in Kvarner area - unveiling of the Kvarner fault]]></title_en><user_id>13721</user_id><user_firstLast_name>Tvrtko Korbar</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2016-06</proposal_call><code>IP-2016-06-1854</code><acronim><![CDATA[GEOSEKVA]]></acronim><duration>20.03.2017 - 19.09.2021</duration><status>Završio</status><financ_value>130.532,88 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Geologija, Geofizika, </scie_field_hr><scie_field_en>Geology, Geophysics, </scie_field_en><institution_hr><![CDATA[Hrvatski geološki institut]]></institution_hr><institution_en><![CDATA[Croatian Geological Survey]]></institution_en><team_members_id>13023, 13024, 19182, 19285, 19181, 6839, 17774, 19577, 3963, 1343, 40, 12912, 19648, 15919, 19298, 24305, 26640, 11151, </team_members_id><team_members_names><![CDATA[Ladislav  Fuček, Damir Palenik, Stanislav Bergant, Nikola Belić, Marko Špelić, Ozren Hasan, Dea Brunović, Pavle Ferić, Lara Wacha, Maša Surić, Snježana Markušić, Tomislav Fiket, Anna Del Ben, Vanja Kastelic, Krešimir Petrinjak, Marko Budić, Ana Kamenski, Branko Kordić, ]]></team_members_names><keywords_hr><![CDATA[Kvarner, geološka karta, seimički profili, 3D modeli, tektonika, potresi, kvartar, seizmotektonika]]></keywords_hr><keywords_en><![CDATA[Kvarner, geological map, seismic lines, 3D models, tectonics, earthquakes, Quaternary, seismotectonic]]></keywords_en><summary_hr><![CDATA[Šire područje Kvarnera se urbanistički i infrastrukturno ubrzano razvija, što u kombinaciji s kompleksnom geološkom građom i geodinamikom tog prostora povećava ranjivost od geohazardnih događaja, a posljedično i rizik. Epicentralno područje Rijeke obilježava pojava učestalih i relativno blagih potresa uz sporadičnu pojavu umjerenih i jakih potresa, koji su prema povijesnim podatcima uzrokovali i znatnija lokalna razaranja. Vjerojatni uzrok tih potresa je desno horizontalno kretanje duž jedne od glavnih rasjednih zona dinaridskog pružanja, koja je vjerojatno isprekidana još uvijek nejasno definiranom zonom poprečnih kvarnerskih rasjeda, što uz pretpostavljeno gravitacijsko klizanje starijih dinaridskih navlaka, moguće rezultira kompleksnim transpresijsko-transtenzijskim režimom u području Kvarnera. S ciljem što kvalitetnije procjene mehanizama potresa, nužni su geološki 3D modeli izrađeni na temelju suvremenih formacijskih (litostratigrafskih) karata, bušotinskih podataka, te interpretiranih seizmičkih profila. Neotektonika se može detektirati putem analize najmlađih naslaga iz plitkog podmorja (geo-akustična snimanja), daljinskih i izravnih istraživanja geomorfoloških formi te putem (re)interpretacije i datiranja kvartarnih naslaga na kopnu. Objedinjavanjem svih navedenih podataka u seizmotektonski model napravila bi se kvalitetna podloga za daljnja interdisciplinarna istraživanja i integraciju novih geoloških i seizmoloških podataka te uključivanje geodetski definiranih pomaka, s ciljem izrade relevantnog geodinamskog modela.]]></summary_hr><summary_en><![CDATA[The wider area of Kvarner has rapid urbanistic and infrastructural growth that, concerning the complex geological structure of this area, increases vulnerability of geohazard events and the risk. Rijeka epicentral area is known for the frequent occurrence of relatively weak earthquakes and occasional occurrence of moderate or large earthquakes, which, according to historical documents, caused locally very strong damage. The probable cause of the earthquakes is the dextral horizontal movement along one of the major fault zones with a Dinaridic strike, that is probably fragmented by a still inadequately defined system of transversal Kvarner faults, which in combination with the assumed gravitational sliding of early orogenic thin-skinned tectonic cover, probably resulted with a very complex transpressional-transtensional regime in the Kvarner region. With the aim to improve the interpretation of the earthquake mechanisms, there is a growing need for 3D geological models based on modern lithostratigraphic maps, borehole data, and interpreted seismic lines. Neotectonics can be detected by analyses of the youngest deposits on the shallow subbottom (geo-acoustical method), by remote and direct study of selected geomorphological features, and by (re)interpretation and dating of Quaternary deposits on land. Compilling the data in the integrated seismotectonic model would be a quality base for the next step, which would include further interdisciplinary research, i.e. integration of more detailed geological and seismological, as well as geodetic data, with the aim to build a relevant geodynamic model of the Kvarner region.]]></summary_en></project><project>
<id>4304</id><title_hr><![CDATA[Mikrosatelitna nestabilnost (MSI i EMAST) u molekularnom profiliranju sporadičnih karcinoma debelog crijeva]]></title_hr><title_en><![CDATA[Microsatellite instability (MSI and EMAST) in molecular profiling of sporadic colon cancer]]></title_en><user_id>12621</user_id><user_firstLast_name>Sanja Kapitanović</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2016-06</proposal_call><code>IP-2016-06-1430</code><acronim><![CDATA[MSIandEMASTinCRC]]></acronim><duration>15.05.2017 - 14.01.2022</duration><status>Završio</status><financ_value>131.780,48 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>12624, 12651, 13128, 12693, 5103, 19360, 5467, 13140, 20089, 6515, 12941, 12988, 13124, 25005, 26763, 19670, </team_members_id><team_members_names><![CDATA[Tamara Čačev, Tina Catela Ivković, Emilija  Zapletal, Tanja Matijević Glavan, Gorana Aralica, Arijana Pačić, Leonardo Patrlj, Božo Lončar, Robert Kliček, Mislav  Rakić, Anita Škrtić, Mirko Poljak, Senka Radošević, Kristina Vuković, Anamarija Salar, Sonja Marinović, ]]></team_members_names><keywords_hr><![CDATA[karcinom debelog crijeva, mikrosatelitna nestabilnost, MSI, EMAST, NLRP3, molekularno profiliranje]]></keywords_hr><keywords_en><![CDATA[colon cancer, microsatellite instability, MSI, EMAST, NLRP3, molecular profiling]]></keywords_en><summary_hr><![CDATA[Zloćudni tumori predstavljaju jedan od vodećih zdravstvenih problema u svijetu. Karcinom debelog crijeva je jedan od najčešćih zloćudnih tumora i jedan od vodećih uzroka smrti od raka u zemljama razvijenog svijeta. Najveći broj karcinoma debelog crijeva javlja se u sporadičnom obliku, a nastaje kao posljedica stupnjevitog procesa tijekom kojeg kao posljedica stečenih mutacija nastaje zloćudni invazivni tumor. Poznato je da mikrosatelitna nestabilnost (MSI) kao i mikroRNA (miRNA) koje reguliraju ekspresiju gena također imaju ulogu u tumorigenezi ovog tumora. EMAST (od engl. Elevated Microsatellite Alterations at Selected Tetranucleotide repeats) je oblik mikrosatelitne nestabilnosti čiji je nastanak potaknut upalom, a koji utječe na napredovanje tumorske bolesti. Rezultati naših prijašnjih istraživanja ukazuju na ulogu upalnih citokina u tumorigenezi karcinoma debelog crijeva. Ovim ćemo projektom istraživanja proširiti na inflamasom NLRP3 za kojeg je pokazano da utječe na tumorigenezu s upalom povezanih gastrointestinalnih tumora. Cilj ovog projekta je ispitati mikrosatelitnu nestabilnost tipa MSI i EMAST u sporadičnim karcinomima debelog crijeva te rezultate korelirati s kliničko-patološkim karakteristikama tumora i oboljelih. Tumore ćemo molekularno profilirati s obzirom na učestalost i distribuciju MSI i EMAST te mutacija u genima koji kodiraju molekule ključnih signalnih puteva (KRAS/BRAF, p53). Rezultati će također biti korelirani s naslijeđenim genetskim profilima oboljelih temeljenim na polimorfizmima inflamasoma NLRP3 i citokina kao i s ekspresijom gena od interesa na razini mRNA, miRNA i proteina. Očekujemo da će rezultati istraživanja doprinjeti rasvjetljavanju molekularne osnove sporadičnih karcinoma debelog crijeva, te naći primjenu u praćenju i liječenju oboljelih.]]></summary_hr><summary_en><![CDATA[Cancer is one of the most important health issues of today and number of cancer cases is expected to increase in the future. Colon cancer is one of the most common cancers and the second leading cause of cancer death in the Western world. Most cases of colon cancer occur in sporadic form and follow the adenoma-carcinoma sequence. The development of the sporadic colon cancer is a result of the accumulation of sporadic mutations in many different genes, oncogenes, tumor suppressor genes as well as mismatch repair genes. It is known that microsatellite instability (MSI) as well as microRNAs (miRNAs) as regulators of gene expression also have a role in sporadic CRC tumorigenesis. Elevated microsatellite alterations at selected tetranucleotide repeats (EMAST) is a form of microsatellite instability that is initiated by inflammation and modulates colon cancer progression. The results of our previous study suggest the role of inflammatory cytokines in colon cancer tumorigenesis. In this project the research will be extended to NLRP3 inflammasome, a potent inducer of proinflammatory cytokines. The main goal of this project is to investigate MSI and EMAST microsatellite instability in sporadic colon cancer and to correlate the obtained results with clinico-pathological characteristics of tumors and patients. Tumors will be molecularly profiled with regard to frequency and distribution of MSI and EMAST and mutations in key cancer pathways (KRAS/BRAF, p53). In addition results will be correlated with patients’ inherited genetic profiles based on inflammasome NLRP3 and cytokine polymorphisms as well as expression of specific genes on mRNA, miRNA and protein level. We expect that our results will contribute to the elucidation of molecular basis of sporadic colon cancer, and be useful in patients’ surveillance and treatment.]]></summary_en></project><project>
<id>4305</id><title_hr><![CDATA[Preuređivanje memorije: Manipuliranje T-staničnom memorijom u svrhu unapređenja učinkovitosti cjepiva]]></title_hr><title_en><![CDATA[Rewriting memory; Manipulation of T cell memory to enhance vaccine efficiency]]></title_en><user_id>19051</user_id><user_firstLast_name>Felix Wensveen</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2016-06</proposal_call><code>IP-2016-06-8027</code><acronim><![CDATA[T-MEMORY]]></acronim><duration>01.07.2017 - 30.11.2021</duration><status>Završio</status><financ_value>132.722,81 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Medicine]]></institution_en><team_members_id>19737, 19748, 25630, 29106, </team_members_id><team_members_names><![CDATA[Marko Šestan, Inga Kavazović, Mia Krapić, Dora Gašparini, ]]></team_members_names><keywords_hr><![CDATA[T Stanična memorija, infekcija, rak, Eomes, T stanični receptor]]></keywords_hr><keywords_en><![CDATA[T cell memory, infection, cancer, Eomes, T cell receptor]]></keywords_en><summary_hr><![CDATA[Imunost posredovana CD8 T-limfocitima pruža nam zaštitu od brojnih patogena i tumora. Naivni repertoar limfocita T se sastoji od milijuna različitih klonova koji se međusobno razlikuju po specifičnosti svojih T-staničnih receptora. Prilikom infekcije, samo neki od klonova postaju dugovjeke memorijske stanice. Selekcijski proces odabira memorijskih klonova reguliran je ravnotežom između specifičnosti i raznolikosti kako bi se osigurao učinkovit sekundarni odgovor te mogućnost prepoznavanja istih, mutiranih antigena. Mehanizmi koji kontroliraju raznolikost memorije još uvijek nisu razjašnjeni. Naša grupa je prepoznala Eomes kao ključni transkripcijski čimbenik za formiranje memorije, no kako pojačana ekspresija Eomesa rezultira stvaranjem imunološke memorije je idalje nepoznato.	U ovom projektu, istražit ćemo utjecaj intenziteta signala i aktivacije T-staničnog receptora na formiranje memorije putem Eomes-a. Prvo ćemo ispitati kako razlike u jačini stimulacije utječu na kvantitativnu i kvalitativnu aktivaciju glavnih nizvodnih komponenti te način na koji se taj signal prevodi u određenu razinu ekspresije Eomes-a. Paralelno, proučavat ćemo i način na koji Eomes pretvara taj aktivirajući signal određene jačine u molekularni proces koji rezultira stvaranjem imunološke memorije. U trećoj fazi projekta utvrditi ćemo ključne čimbenike koji posreduju tim procesima. Još bitnije, usredotočit ćemo se na čimbenike koji mogu imati terapeutsku primjenu kako bi testirali učinkovitost specifičnog ciljanja tih molekula na unaprjeđenje antitumorskih i antivirusnih cjepiva.	Ovdje predstavljeni projektni prijedlog, osim iznimne inovativnosti, ima velike izglede za uspjeh budući da se temelji na velikoj količini preliminarnih rezultata. Uz to, jedna od ključnih prednosti je i naše dugogodišnje iskustvo i rad u području imunologije i istraživanja na životinjama. Stoga držimo da je ovaj projekt izvrsna investicija u hrvatsku akademsku zajednicu koja pomaže razvoju nove istraživačke grupe.]]></summary_hr><summary_en><![CDATA[CD8 T cell mediated immunity protects us against pathogens and cancer. The naive T cell pool consists of millions of clones, each one unique based on its T cell receptor (TCR). Upon infection, only a few of these clones are recruited to generate antigen-specific memory. Selection of memory clones is a trade-off between specificity and diversity to ensure both an efficient recall response and recognition of a sufficient number of targets. Mechanisms controlling memory diversity are largely unclear. Recently, we have identified the transcription factor Eomes as a key mediator of memory formation. How Eomes induction results in shaping of the memory cell pool is currently unknown.  	In this project, we will study the impact of activating T cell receptor signal intensity on memory formation via the transcription factor Eomes. First, we will investigate how TCR signal strength impacts the quality and quantity of activation of its main downstream components and how this translates into the activation of Eomes. In parallel, we will investigate how Eomes translates TCR-activating stimuli of a given strength in a molecular process that promotes memory formation. Using the combined information of these two lines of inquiry, we will identify and validate key factors that mediate these processes in the third phase of the project. Importantly, we will select for molecules that can be targeted by pharmacological means. Finally, we will test the potency of therapeutic intervention for the improvement of antiviral and anti-cancer vaccines. 	The proposal described here is both innovative, and has a high chance of success, since it is based on a large amount of preliminary data. This project builds on the strengths that our department has developed in the fields of immunology and animal research, while adding a fresh impulse of innovation. We therefore believe that this project is a solid investment in Croatian academia and aids in the development of a strong new research group. ]]></summary_en></project><project>
<id>4306</id><title_hr><![CDATA[Transformacija pepela iz drvene biomase u građevne kompozite s dodanom vrijednošću]]></title_hr><title_en><![CDATA[Transformation of Wood Biomass Ash into Resilient Construction Composites]]></title_en><user_id>3406</user_id><user_firstLast_name>Nina Štirmer</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2016-06</proposal_call><code>IP-2016-06-7701</code><acronim><![CDATA[TAREC2]]></acronim><duration>01.03.2017 - 28.02.2021</duration><status>Završio</status><financ_value>125.738,27 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Temeljne tehničke znanosti, Građevinarstvo, </scie_field_hr><scie_field_en>Basic engineering sciences, Civil engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Građevinski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Civil Engineering]]></institution_en><team_members_id>4319, 5060, 7510, 3023, 19775, 20012, 19926, 1276, 19910, 7662, 3218, 21277, 24284, 25367, 17806, </team_members_id><team_members_names><![CDATA[Bojan Milovanović, Ana Baričević, Ivana Banjad Pečur, Neven Ukrainczyk, Eduardus Koenders, Virna Višković-Agušaj, Ivana Carević, Ivan Gabrijel, Velimir Šegon, Dubravka  Bjegović, Marija Jelčić Rukavina, Ivan Rimac, Karmen Kostanić Jurić, Jelena Šantek Bajto, Martina Grubor, ]]></team_members_names><keywords_hr><![CDATA[drvna biomasa, pepeo drvne biomase, mineralni kompozit, građevni proizvod, trajnost]]></keywords_hr><keywords_en><![CDATA[wood biomass, wood biomass ash, mineral composite, construction product, durability ]]></keywords_en><summary_hr><![CDATA[Energane na krutu i plinovitu biomasu predstavljaju jedan od najznačajnijih obnovljivih izvora energije u Europskoj uniji te se očekuje da će biti jedan od glavnih aktera pri dostizanju europskog plana za primjenu 20 % obnovljive energije u 2020. Uobičajeno se tijekom izgaranja 1 tone drvne biomase proizvede 5 MWh energije, ali i 20 – 50 kg pepela s dna peći kao i letećeg pepela. Predviđa se da će u EU-28 primjena energije iz energana na drvnu biomasu u budućnosti utjecati na proizvodnju približno 600 000 tona pepela. Trenutno se 70 % biopepela drvne biomase (PDB) odlaže, 20 % se nastoji primijeniti kao dodatak tlu u poljoprivredi i 10 % za ostale namjene. Strategijom energetskog razvoja RH određeno je da će se do 2020. godine koristiti 85 MWe iz biomase. U ožujku 2016. u Hrvatskoj je bilo 10 elektrana na biomasu, potpisano je 57 ugovora s Hrvatskim operatorom tržišta energije za gradnju elektrana u 2014. i 2015. godini (ukupno 95,342 MWe) te su zaprimljeni zahtjevi za odobrenje građenja dodatnih elektrana na biomasu snage 51,034 MWe.Cilj projekta TAREC2 je transformirati pepeo drvne biomase (PDB) u građevne kompozite s dodanom vrijednošću, kroz povezivanje tri ključna aktera s njihovim specifičnim interesima, u industrijsku simbiozu sa zajedničkim komplementarnim interesom, koji je u skladu s EU pravnim okvirima. Prvi akter je energetski sektor koji je korisnik drvne biomase kako bi proizveo energiju i kao rezultat toga proizvođač otpada drvne biomase. Drugi je građevinski sektor koji je korisnik sirovine koju proizvodi energetski sektor. Na kraju, znanost o materijalima služi kao poveznica između dva sektora koja osigurava podatke o sirovini i moguće primjene. Projekt uključuje i optimizaciju i modifikaciju cijelog lanca u tehnologiji procesa: dobivanje pepela iz energetskog procesa, karakterizaciju pepela, određivanje udjela sastojaka mješavine za građevinsku industriju i konačno demonstraciju razvijenog proizvoda i primjenu u građevinskoj industriji. ]]></summary_hr><summary_en><![CDATA[Solid and gaseous biomass fuelled power plants are the biggest source of renewable energy in the EU and are expected to make a key contribution to the 20% EU renewable energy target by 2020. Typically burning of 1 tons of forest biomass and wood waste generates 5 MWh of energy as well as 20 – 50 kg/t of bottom ash and fly ash. It is foreseen that the use of energy from wood biomass plants will lead in the future to the production of approximately 600 000 tons of biomass ash in the EU-28. Currently, 70% of wood biomass ash (WBA) is land filled, 20% tends to be used as a soil supplement in agriculture and 10% is used for miscellaneous application. Energy Sector Development Strategy of the Republic of Croatia determined that by 2020 use of energy from biomass should be 85 MW. In March 2016, there were 10 biomass power plants installed (total power 24.585 MWe). Additionally, 57 contracts were signed with Croatian energy market operator for construction of power plants during 2014 and 2015 (in total 95.342 MWe), while HROTE received requests for approval of construction of additional 51.034 MWe of biomass power plants.TAREC2 aims to transform waste wood biomass ash (WBA) into resilient construction composites, through incorporating three key actors, into an industrial symbiosis with joint complementary interest that is in accordance with EU legal framework. First key actor is the energy sector; user of wood biomass to produce energy and consequently producer of waste wood biomass ash. Another one is construction industry; user of raw material provided by the energy sector. Finally, materials science acts as a bridge between the two sectors, providing information on properties of obtained material and potential application. Project involves the optimization and the modification of the whole chain of process technology: ash obtaining and characterization, mixture proportioning and demonstration of the developed products and the applications in construction industry.]]></summary_en></project><project>
<id>4309</id><title_hr><![CDATA[Ekološki odziv sjevernog Jadrana na klimatske promjene i antropogeni učinak ]]></title_hr><title_en><![CDATA[Ecological response of northern Adriatic to climatic changes and anthropogenic impact]]></title_en><user_id>468</user_id><user_firstLast_name>Nastenjka Supić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2016-06</proposal_call><code>IP-2016-06-4764</code><acronim><![CDATA[EcoRENA]]></acronim><duration>27.03.2017 - 26.04.2022</duration><status>Završio</status><financ_value>132.722,81 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Geofizika, Kemija, Biologija, </scie_field_hr><scie_field_en>Geophysics, Chemistry, Biology, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>3596, 467, 3277, 1020, 287, 3992, 1155, 4424, 429, 21415, 473, </team_members_id><team_members_names><![CDATA[Robert Precali, Tamara Đakovac, Davor Lučić, Mathieu Dutour Sikirić, Irena  Ciglenečki-Jušić, Jakica Njire, Jelena Dautović, Daniela Maric Pfannkuchen, Romina Kraus, Nataša Kužat, Paolo Paliaga, ]]></team_members_names><keywords_hr><![CDATA[klimatske promjene, antropogeni učinak, ekosustav, ekološki model, sjeverni Jadran]]></keywords_hr><keywords_en><![CDATA[climatic changes, anthropogenic impact, ecosystem, ecological model, northern Adriatic ]]></keywords_en><summary_hr><![CDATA[Zbog plitkoće i zatvorenosti  sjeverni je Jadran osobito osjetljiv na vanjske utjecaje, a pogotovo na promjene površinskih protoka vlage, energije i tvari. Prepoznat je kao sredozemna “vruća točka” klimatskih promjena jer se očekuje da će u budućnosti  biti pod bitno većim okolišnim pritiscima od većine drugih morskih sustava. Područje ima i širu veću važnost jer u njemu zimi nastaje gusta pridnena voda koja izlazi iz Jadrana i prenosi prenoseći hranjive soli i kisik u Sredozemno more. Zimski uvjeti sjevernog Jadrana su, kako je nedavno ustanovljeno, ključni za porast odnosno smanjenje populacije jedne od najkomercijalnijih jadranskih vrsta, inćuna.  Ekosustavu sjevernog Jadrana, između ostalog, često prijeti dolazak alohtonih vrsta, te neželjene i vrlo štetne pojave različitog intenziteta i trajanja (npr. pojava masovnih sluzavih nakupina ili izrazita potrošnja/potpuni nedostatak kisika u pridnenom sloju).  Oceanografska baza Centra za istraživanje mora iz Rovinja, koja sadrži dugogodišnji niz podataka (od 1920. g.) temelj je tzv. ekološkog empirijskog modela (EEM) koji objašnjava promjene u sustavu sjevernog Jadrana povezujući ih s promjenama dinamike vodenih masa i geostrofičkih struja, te površinskim i riječnim protocima. Upoznavanje odziva sjevernog Jadrana na različite pritiske, a osobito one koji su povezani s klimatskim promjenama i antropogenim učincima (npr. acidifikacija i eutrofikacija), cilj je ovog projekta.Prikupljanje novih podataka te korištenje numeričkog modela omogućit će proširenje i preispitivanje postojećih znanja o promjenama sjevernojadranskog ekosustava, a osobito priobalne zone. Takvo će istraživanje omogućiti i ispitivanje odziva ekosustava na predviđene promjene, a zbog širokog raspona ekoloških karakteristika sjevernog Jadrana, rezultati istraživanja bit će primjenjivi i na druge morske sustave.]]></summary_hr><summary_en><![CDATA[The northern Adriatic (NA) of a semi-enclosed nature and shallowness makes it highly reactive to the external forcing, in particular to variations of water, energy and matter fluxes at interfaces. Identified as the Mediterranean&#39;s climatic change „hotspot“ the region expects to undergo environmental impacts, considerably greater than in many other marine systems. The region deserves a special interest as an area of winter dense water formation which flows out of the Adriatic and brings nutrients and oxygen to the Mediterranean. Winter conditions in NA are crucial for increase/decrease in population of one of the most commercial fish species of the region, anchovy, as it has been recently established. Threats to the ecosystem are among others due to the intrusion of alohtone species, and undesirable phenomena of different intensity and duration (e. g. appearance of large mucilage aggregates or bottom anoxia events).  The Center for Marine Research-Rovinj&#39;s long-term  oceanographic data base (since 1920) was ground for development of an “empirical ecological model” (EEM) explaining changes in NA ecosystem relating them to changes in water masses dynamics and geostrophic currents, air-sea fluxes and riverine discharge. Response of the NA to various forcing and especially those related to climatic changes and anthropogenic impacts (acidification and eutrophication) is the aim of the EEM.Acquisition of new data and support of a numerical model will allow an extension and re-examination of existing knowledge on NA ecosystem changes, especially in the coastal zone. This research will enable to build scenarios of possible ecosystem reactions to predicted environmental changes, and due to a wider spectrum of ecological characteristics of NA finally can be applied in a wider sense to other marine systems. ]]></summary_en></project><project>
<id>4313</id><title_hr><![CDATA[Povećanje energetske učinkovitosti izmjenjivača topline]]></title_hr><title_en><![CDATA[Enhancement of the heat exchanger energy efficiency]]></title_en><user_id>5302</user_id><user_firstLast_name>Anica Trp</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2016-06</proposal_call><code>IP-2016-06-4095</code><acronim><![CDATA[HEXENER]]></acronim><duration>15.03.2017 - 01.09.2021</duration><status>Završio</status><financ_value>121.481,19 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Strojarstvo, Temeljne tehničke znanosti, </scie_field_hr><scie_field_en>Mechnical engineering, Basic engineering sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Tehnički fakultet]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Engineering]]></institution_en><team_members_id>5298, 19388, 6050, 6289, 5146, 6950, 19407, 19392, 21279, 25384, </team_members_id><team_members_names><![CDATA[Kristian Lenić, Branimir Pavković, Vladimir Glažar, Igor Wolf, Paolo Blecich, Igor Bonefačić, Boris Delač, Mateo Kirinčić, Fran Torbarina, Josip Batista, ]]></team_members_names><keywords_hr><![CDATA[energetska učinkovitost, lamelni izmjenjivači topline, latentni spremnik topline, obnovljivi izvori energije, numeričke simulacije, eksperiment]]></keywords_hr><keywords_en><![CDATA[energy efficiency, fin and tube heat exchanger, latent heat storage, renewable energy sources, numerical simulations, experiment]]></keywords_en><summary_hr><![CDATA[Predmet istraživanja projekta je povećanje energetske učinkovitosti izmjenjivača topline. Istraživanja će biti usmjerena na analizu izmjene topline i povećanja energetske učinkovitosti lamelnih izmjenjivača topline te latentnog spremnika topline kao posebnog tipa izmjenjivača. Znanstveno-istraživački ciljevi projekta usmjereni su na produbljivanje znanstvenih spoznaja u području izmjenjivača topline te obuhvaćaju: numeričko i eksperimentalno istraživanje utjecaja geometrijskih karakteristika i pogonskih uvjeta izmjenjivača topline na fizikalni proces izmjene topline i učinkovitost, numeričko i eksperimentalno istraživanje utjecaja pogonskih uvjeta, geometrije i karakteristika akumulatora topline na izmjenu topline i učinkovitost latentnih spremnika te istraživanje pohrane energije u sustavu obnovljivih izvora energije s latentnim spremnikom.U okviru projekta nabavit će se i instalirati eksperimentalna oprema potrebna za provođenje eksperimentalnog dijela istraživanja. U svrhu provedbe numeričkih analiza, za svaki od problema istraživanja, definirat će se domena numeričkog proračuna, postaviti matematički model, odabrati numerička metoda i provesti numeričko rješavanje. Postavljeni matematički i računalni modeli bit će provjereni usporedbom rezultata s rezultatima eksperimentalnog istraživanja. Nakon provjere valjanosti, provest će se nizovi numeričkih simulacija u svrhu ispitivanja utjecaja različitih geometrijskih karakteristika i pogonskih uvjeta lamelnih izmjenjivača topline, kao i utjecaja pogonskih uvjeta, geometrije i karakteristika akumulatora topline latentnog spremnika na izmjenu topline i učinkovitost. Provest će se računalna analiza sustava obnovljivih izvora energije s latentnim spremnikom topline, za različite pogonske uvjete i dimenzije komponenata sustava. Očekivani rezultati i znanstveni doprinos obuhvaćaju proširenje postojećih znanstvenih spoznaja i prijedlog mjera za poboljšanje u svrhu povećanja energetske učinkovitosti izmjenjivača topline.]]></summary_hr><summary_en><![CDATA[The research topic of the project is the enhancement of the heat exchanger energy efficiency. Investigations will focus on the analysis of heat transfer and energy efficiency enhancement of the fin and tube heat exchanger and the latent heat storage as special type of heat exchanger.Scientific research objectives of the project are focused on enlarging of scientific knowledge in field of heat exchangers and include: numerical and experimental research of influence of heat exchanger geometry characteristics and operating conditions, as well as influence of latent heat storage operating conditions, geometry and phase change material characteristics on heat transfer and efficiency. Also, energy storing in system of renewable energy sources with latent heat storage will be studied.Experimental equipment, needed to carry out experimental part of the research, will be acquired and installed as part of the project. For purposes of numerical analysis, for each problem, domain for numerical calculation will be defined, mathematical model will be set up, numerical method will be chosen and numerical calculations will be performed. The established mathematical and computer models will be validated by comparing results with the results of experiments. After validation, series of numerical simulations will be carried out to investigate influence of different geometry characteristics and operating conditions of the fin and tube heat exchangers, as well as effects of operating conditions, geometry and characteristics of phase change material on heat transfer and efficiency of latent heat storage. Computational analysis of renewable energy system with latent heat storage, for different operating conditions and dimensions of system components, will be carried out.Expected results and scientific contributions include the enlarging of existing scientific knowledge and proposal of measures for improvement in order to enhance the heat exchanger energy efficiency.]]></summary_en></project><project>
<id>4314</id><title_hr><![CDATA[Genomske i epigenomske promjene u auto- i alopoliploidima na modelu dalmatinskog buhača, ljutike i anemona]]></title_hr><title_en><![CDATA[Genomic and epigenomic changes in auto- and allopolyploids: case studies on dalmatian pyrethrum, shalot and anemone]]></title_en><user_id>19769</user_id><user_firstLast_name>Višnja Besendorfer</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2016-06</proposal_call><code>IP-2016-06-8432</code><acronim><![CDATA[AutoAloPol]]></acronim><duration>01.04.2017 - 31.10.2022</duration><status>Završio</status><financ_value>129.802,91 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Biologija, Kemija, </scie_field_hr><scie_field_en>Biology, Chemistry, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>3735, 4503, 19883, 19875, 19978, 19982, 25319, 29194, </team_members_id><team_members_names><![CDATA[Nenad Malenica, Ivana Ivančić Baće, Jelena Mlinarec, Jasna Puizina, Ivica Šamanić, Željana Fredototvić, Adela  Jurković, Mila Vuković, ]]></team_members_names><keywords_hr><![CDATA[autopoliploidija, alopoliploidija, genomika, epigenomika, evolucija biljnog genoma]]></keywords_hr><keywords_en><![CDATA[autopolyploidy, allopolyploidy, genomic, epigenomic, plant genome evolution]]></keywords_en><summary_hr><![CDATA[Poliploidija/udvostručavanje genoma glavni je pokretački mehanizam specijacije i bioraznolikosti biljaka koji dovodi do stvaranja novih genetičkih varijanti, pokreće evoluciju, povećava genetičku raznolikost organizama te ima veliku ulogu u domestikaciji biljaka. Iako su rađena brojna istraživanja još uvijek se malo zna o promjenama koje se događaju na razini genoma nakon poliploidizacije i hibridizacije. Auto- i alopoliploidija dovodi do nestabilnosti i reorganizacije genoma. Nepravilna segregacija kromosoma u mejozi glavni je problem za formiranje funkcionalnih gameta i uspješnog spolnog razmnožavanja novosintetiziranih autopoliploida. Evolucijski stari autopoliploidi razvili su mehanizme koji su s vremenom osigurali pravilnu segregaciju kromosoma. Točan mehanizam prelaska iz nestabilnog u stabilno stanje genoma nakon poliploidizacije još je nerazjašnjeno. Ovim projektom istražit će se mejotski procesi koji dovode do pravilne segregacije kromosoma i ekspresija gena uključenih u sparivanje kromosoma/homolognu rekombinaciju u autotetraploidu dalmatinskog buhača (T. cinerariifolium). Stabilizacija mejoze kroz mali broj generacija važna je za komercijalnu proizvodnju autotetraploida. Genomi alopoliploidnih vrsta izuzetno su dinamični zbog interakcija između subgenoma koje dovode do homogenizacije alopoliploida. Homogenizacija se odvija kroz genomske rearanžmane (inverzije, translokacije, trasnpozicije) i delecije dijelova genoma u koje su najčešće uključene ponavljajuće DNA kao i promjene u metilaciji DNA. Ovim projektom žele se na razini genoma i epigenoma utvrditi koji mehanizmi i u kojoj mjeri su uključeni u reorganizaciju genoma sterilne alotriploidne ljutike (A. × cornutum), fertilne alotetraploidne vrste A. multifida i aloheksaploidne A. baldensis. Istraživanja predložena ovim projektom pružit će bolji uvid u promjene na razini genoma i epigenoma u vrstama važnim za ljudsku prehranu, ekološku poljoprivredu i proizvodnju novih hortikulturnih varijanti.]]></summary_hr><summary_en><![CDATA[Polyploidy/genome duplication is the main mechanism of speciation and biodiversity in plants, drives evolution, increases genetic diversity and organism complexity, and plays an important role in domestication of plants. Although numerous studies have been conducted so far, we still don’t know enough about the genomic changes that are taking place after polyploidization and hybridization. Auto- and allopolyploidy lead to genome instability and reorganization. Improper chromosome segregation in meiosis is the main problem for functional gamete formation and successful sexual reproduction in neo-autopolyploids. Evolutionary old autopolyploids have developed mechanisms that lead to proper chromosome segregation but the exact mechanism of transition from unstable to stable genome condition after polyploidization is not fully understood. This project will study meiotic processes that lead to the proper chromosome segregation as well as gene expression involved in chromosome pairing/homologous recombination in autotetraploid pyrethrum (T. cinerariifolium). Stabilization of meiosis through a few generations is important for commercial production of autotetraploids. Genomes of allopolyploid species are extremely dynamic in terms of their subgenome interactions that lead to their homogenization. Homogenization is carried out through genomic rearrangements (inversions, translocations, transposition) and partial genome (rich in repetitive DNA) deletions as well as changes in DNA methylation. With this project we want to determine the mechanisms at the genome and the epigenome level which are involved in reorganization of subgenomes in sterile allotriploid shallot (A. x cornuntum) and fertile allotetraploid A. multifida and allohexaploid A. baldensis. The research proposed in this project will provide a better insight into changes at the genomic and epigenomic level in species important for human consumption, organic farming and the production of new horticultural varieties.]]></summary_en></project><project>
<id>4315</id><title_hr><![CDATA[Automatsko raspoznavanje akcija i aktivnosti u multimedijalnom sadržaju iz domene sporta]]></title_hr><title_en><![CDATA[Automatic recognition of actions and activities in multimedia content from sports domain]]></title_en><user_id>4775</user_id><user_firstLast_name>Marina Ivašić-Kos</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2016-06</proposal_call><code>IP-2016-06-8345</code><acronim><![CDATA[RAASS]]></acronim><duration>01.01.2017 - 31.05.2021</duration><status>Završio</status><financ_value>78.704,63 eur</financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Informacijske znanosti, Kineziologija, </scie_field_hr><scie_field_en>Information sciences, Kinesiology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Fakultet informatike i digitalnih tehnologija]]></institution_hr><institution_en><![CDATA[University or Rijeka, Faculty of Informatics and Digital Technologies]]></institution_en><team_members_id>19832, 20125, 20342, 25244, 25880, </team_members_id><team_members_names><![CDATA[Miran Pobar, Matija Burić, Jordi Gonzalez Sabaté, Kristian Stančin, Kristina Host, ]]></team_members_names><keywords_hr><![CDATA[raspoznavanje akcija, predstavljanje znanja, algoritmi zaključivanja, prostorno-vremenske značajke, vremenske neizrazite Petrijeve mreže]]></keywords_hr><keywords_en><![CDATA[action recognition, knowledge representation, inference algorithms, STIP features, timed Fuzzy Petri nets]]></keywords_en><summary_hr><![CDATA[Multimedijalni materijali poput digitalnih slika i videa postale su važan medij za pohranu i razmjenu informacija. U domeni sporta stvara se velik broj multimedijalnih materijala s različitih takmičenja, utakmica ili priprema te postoji jak interes za njihovom analizom kod sportaša i trenera, od amaterskih, preko profesionalnih do rekreativnih. U profesionalnom sportu takva analiza je danas neophodna ali još se uvijek vrši uglavnom ručnim označavanjem pojedinih akcija. Razvoj postupaka za automatsku detekciju akcija i tumačenje aktivnosti sportaša omogućio bi učinkovitiju analizu i širu dostupnost takvih rješenja svima koji se žele baviti sportom. Analiza pojedinih akcija kao što su npr. okret kod plivanja ili korak kod trčanja važna je za sportaše, trenere i fizioterapeute jer omogućuje praćenje točnosti izvođenja vježbi, unaprjeđenje njihove izvedbe te praćenje napretka. Za tumačenje više slijednih akcija i njihovo povezivanje u smislenu aktivnost potrebno je znanje iz domene sporta. Predlaže se istraživanje u kojem bi se razvili postupci za detekciju i označavanje akcija iz domene sporta u multimedijalnom sadržaju. Polazna točka za detekciju akcija bit će postupci temeljeni na strojnom učenju i značajkama koje opisuju prostorno-vremensku dimenziju multimedijalnog sadržaja. Za automatsko povezivanje i interpretaciju slijednih akcija u složenije aktivnosti razvit će se model temeljen na znanju o domeni sporta koja ima dobro definirana pravila, poznatu strukuru i kontekst te postoje jasne uloge sportaša i ostalih sudionika. Za modeliranje neizrazitog znanja o domeni i vremenskih odnosa definirat će se shema za predstavljanje znanja temeljena na teoriji vremenskih i neizrazitih Petrijevih mreža ili sličan formalizam. Zbog specifičnosti svakog sporta, u istraživanju će se razmatrati akcije iz odabranih sportova, no pri tome će se imati u vidu mogućnost primjene postupaka i na druge sportove. ]]></summary_hr><summary_en><![CDATA[Multimedia content such as digital images and video have become an important storage and exchange media. A large amount of such content from competitions, games and training sessions is constantly being created in the sports domain, and there has been a great interest for multimedia content analysis among athletes and coaches, on all levels from professional to recreational.Such analysis is indispensable in modern professional sports but is still done primarily by manual annotation of individual actions. Development of methods for automatic action detection and athlete’s activity interpretation would enable more efficient analysis and broaden the availability of analysis solutions to everyone involved with sports.Analysis of individual actions, such as swimming turns or steps in running, is important for athletes, coaches and physical therapists alike because it allows them to monitor the form of performing individual exercises, to improve the athlete’s performance and and to keep track of the progress. For interpretation of multiple sequential actions into a meaningful activity, sports domain knowledge is necessary.We propose a research in which methods for sports domain action detection and annotation in multimedia content would be developed. The starting point for action detection are methods based on machine learning and features that describe the spatio-temporal dimensions of multimedia content. For interpretation of sequential actions into more complex activities a model will be developed based on sports domain, which has well-defined rules, a known structure and context and clear roles exist for athletes and others involved. To model the fuzzy knowledge of the domain and temporal relations a knowledge representation scheme will be defined based on the theory of timed and fuzzy Petri nets or a similar formalism. Due to the specifics of different sports, actions from chosen sports will be considered in the research.]]></summary_en></project><project>
<id>4317</id><title_hr><![CDATA[Analiza složenosti mikrobne dinamike u invadiranim livadama morskih cvjetnica]]></title_hr><title_en><![CDATA[Unravelling the complexity of microbial dynamics in invaded seagrass meadows]]></title_en><user_id>462</user_id><user_firstLast_name>Mirjana Najdek Dragić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2016-06</proposal_call><code>IP-2016-06-7118</code><acronim><![CDATA[MICRO-SEAGRASS]]></acronim><duration>01.04.2017 - 31.08.2021</duration><status>Završio</status><financ_value>132.722,81 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Biologija, Kemija, </scie_field_hr><scie_field_en>Biology, Chemistry, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>465, 12700, 473, 4664, </team_members_id><team_members_names><![CDATA[Ingrid Ivančić, Marino Korlević, Paolo Paliaga, Gerhard Herndl, ]]></team_members_names><keywords_hr><![CDATA[raznolikost mikroorganizama, morske cvjetnice, epifitski mikroorganizmi, bentički mikroorganizmi, NGS, izvori organske tvari, metabolički putevi]]></keywords_hr><keywords_en><![CDATA[microbial diversity, seagrasses, epiphytic microbes, benthic microbes, NGS, organic matter sources, metabolic pathways]]></keywords_en><summary_hr><![CDATA[Morske su cvjetnice među najvrijednijim biološkim sustavima na Zemlji. Nedavno uvedena u Jadransko more, invazivna makroalga vrste Caulerpa cylindracea (Sonder) predstavlja jednu od glavnih, ali nedovoljno istraženih prijetnji opstanku morskih cvjetnica. Učinak makroalge C. cylindracea na rast cvjetnica može imati sveobuhvatan kaskadni učinak na funkcioniranje ekosustava i podršku koju livade pružaju ekosustavu. Uloga mikroorganizama i njihovih složenih interakcija s morskim cvjetnicama u održavanju rasta i razvoja livada, posebno invadiranih livada nije dovoljno razjašnjena. Predloženi projekt će po prvi puta pružiti uvid u strukturu i raznolikost epifitskih i bentičkih mikrobnih zajednica livada morske cvjetnice vrste Cymodocea nodosa (Ucria) Ascherson i livada invadiranim makroalgom C. cylindracea. Visoka učestalost uzorkovanja omogućit će dubinsku analizu sezonske dinamike epifitskih i bentičkih mikrobnih zajednica. Usporedbom epifitskih i bentičkih mikrobnih zajednica livada cvjetnice C. nodosa i invadiranih livada, procijeniti će se utjecaj makroalge C. cylindracea na strukturu, raznolikost i dinamiku mikrobnih zajednica. Kombiniranjem metagenomskog sa metaproteomskim pristupom dobiti će se uvid u potencijalne i ostvarene mikrobne metaboličke puteve određivanjem funkcije mikroorganizama u ovom vrijednom ekosustavu. Profiliranje masnih kiselina razjasniti će doprinos različitih izvora ukupnoj organskoj tvari livada. Projekt će doprinjeti boljem razumijevanju uloge makroalge C. cylindracea u ekosustavu morskih cvjetnica, utjecaja na strukturu i pokrivenost epifitskim zajednicama, opskrbu bentičke mikrobne zajednice hranjivim tvarima u sedimentu livada, kao i utjecaj na kvalitetu i dostupnost organske tvari višim trofičkim razinama. Na kraju, projekt će značajno unaprijediti znanje o složenosti mikrobne dinamike u invadiranim livadama morskih cvjetnica isporukom dobro strukturiranog vremenskog niza podataka i primjenom molekularnih alata nove generacije.]]></summary_hr><summary_en><![CDATA[Seagrasses are among the most valuable biological systems on Earth. The recent introduction into the Adriatic Sea of the invasive macroalgae, Caulerpa cylindracea (Sonder) is one of the major but less-well understood threats for seagrasses. The impacts of C. cylindracea on seagrass performance can have a widespread cascade effects on ecosystem function and ecosystem services provision. The role of microorganisms and their complex interactions with seagrass, especially in invaded meadows, is poorly understood. The proposed project will deliver unprecedented insights into the structure and diversity of epiphytic and benthic microbial communities in the meadows of Cymodocea nodosa (Ucria) Ascherson and its C. cylindracea invaded meadows. High sampling frequencies will enable in-depth analysis of epiphytic and benthic microbial community seasonal dynamics. By comparison of epiphytic and benthic microbial communities of C. nodosa in non-invaded and invaded meadows, the impact of C. cylindracea on microbial structure, diversity and dynamics will be evaluated. A combination of metagenomic with metaproteomic approach will provide insight into potential and realized microbial metabolic pathways determining the function of microorganisms in this valuable ecosystem. Fatty acid profiling will clarify the contribution of different basal organic matter sources to seagrass meadows. This project will give a better understanding of the role of C. cylindracea in the seagrass ecosystem, its impact on the epiphytic community structure and cover, microbial nutrient cycling in seagrass sediments and influence of the quality and availability of organic matter to higher trophic levels. Finally, the project will substantially improve the knowledge of complex microbial dynamics in invaded seagrass meadows by delivering a well-structured temporal dataset and application of next-generation molecular tools.]]></summary_en></project><project>
<id>4321</id><title_hr><![CDATA[Dinamični hibridni materijali za novu primjenu temeljeni na metalnim nanočesticama i gelovima]]></title_hr><title_en><![CDATA[Dynamic Hybrid Metal Nanoparticles-Gel Materials for Novel Applications]]></title_en><user_id>4406</user_id><user_firstLast_name>Zoran Džolić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2016-06</proposal_call><code>IP-2016-06-5983</code><acronim><![CDATA[NanoGelMat]]></acronim><duration>15.03.2017 - 14.08.2021</duration><status>Završio</status><financ_value>132.722,81 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, </scie_field_hr><scie_field_en>Chemistry, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>5023, 5515, 2816, 25266, 25267, </team_members_id><team_members_names><![CDATA[Mario Cetina, Massimo Cametti, Marijana Vinković, Mateja Belovari, Toni Grgurić, ]]></team_members_names><keywords_hr><![CDATA[supramolekulska kemija, gelovi, metalne nanočestice, plazmoni, meki materijali]]></keywords_hr><keywords_en><![CDATA[supramolecular chemistry, gels, metal nanoparticles, plasmons, soft materials]]></keywords_en><summary_hr><![CDATA[Proučavanje fenomena kiralnosti kod anorganskih nanočestica postaje jedna od vodećih tema istraživanja u nanoznanosti. Otkrivena su nova i zanimljiva svojstva kiralnih nanočestica koja pokazuju buduću primjenu tih sustava u temeljnim (metamaterijali) i primijenjenim (medicinska dijagnostika, terapija karcinoma) istraživanjima. Kiralnost nanočestica je važan parametar u utrci minijaturizacije. Cilj je pripraviti kiralne nanočestice s efektom cirkularnog dikroizma induciranog površinskim plazmonom (SP-CD) u vidljivom i infracrvenom dijelu spektra. Napredak u ovom području istraživanja do sada je bio otežan zbog strukturne složenosti takvih sustava te kompliciranih metoda priprave kiralnih nanočestica. Zbog toga je razvoj učinkovitih metoda priprave kiralnih nanočestica jedan od vodećih izazova s kojim se nanoznanost danas suočava. Nedavno smo izložili novi pristup dizajnu i pripravi kiralnih nanočestica. U njemu je kiralna organizacija nanočestica dobivena upotrebom predloška, supramolekularne gelne niti, po kojem je raspored nanočestica dirigiran &#39;&#39;upisanom informacijom&#39;&#39; unutar gelnih niti. Našim pristupom plazmonski cirkularni dikroizam je dobiven samo-udruživanjem zlatnih nanoštapića po predlošku, gelne niti, s upletenom (engl. twisted) morfologijom. Spektri cirkularnog dikroizma su pokazali intenzivne plazmonom-inducirane Cottonove efekte, a dobivene su do sada najviše vrijednosti anizotropnog faktora za metalne nanočestice u otopini. Predloženi projekt ima za za cilj pojasniti porijeklo fenomena kiralnosti kod anorganskih nanočestica i na molekularnoj razini proširiti saznanja o interakcijama između anorganskih nanočestica i molekula gelatora unutar gelne mreže. Nadalje, unutar ovog projekta planirano je istražiti, upotrebom oksalamidnih derivata kao molekula gelatora, mehanizam nastajanja gelnih niti s kiralnom morfologijom, kao i mogućnosti kontrole dobivene morfologije. ]]></summary_hr><summary_en><![CDATA[The observation of chirality on inorganic nanoparticles (NPs) systems is an interesting and highly important phenomenon which has recently attracted considerable attention and has become a hot topic in nanoscience research. Many novel and interesting properties of chiral NPs have been explored and studied, showing that these systems could be of significant importance in both fundamental and application-oriented research. Very recently we have introduced a new strategy for designing and preparing chiral NPs which relies on a gelator fiber-templated approach in which the local organization is driven by the information already inscribed on the gel fibers. Plasmonic circular dichroism was obtained by chiral 3D organisation of gold nanorods, generated by their self-assembly onto a gel fiber template with twisted morphology. Circular dichroism measurements revealed intense plasmon-induced Cotton effect, and the highest anisotropy factor for metal nanoparticles in solution reported so far. The aim of this project is to gain a molecular-level understanding of the interaction of NPs with the gelators within the gel matrix and of the origin of the chirality observed in the inorganic NPs. Furthermore, a comprehensive understanding of the mechanism of the twist formation and control the chiral twists in oxalamide-based gelator assemblies will be sought. The long-term objective of this project is to explore the correlation between the morphology of the chiral gel fibers and the SP-CD responses of NPs. More specifically, the project will focus on (1) the preparation of nanocomposite chiral materials built-up from supramolecular fibers of different morphology serving as templates for surface assembly of NPs; (2) the screening of their optical properties and on identifying the factors responsible for an efficient optical enhancement; (3) the determination of the characteristics and the origins of the chirality in NPs.]]></summary_en></project><project>
<id>4329</id><title_hr><![CDATA[Sto dvadeset i pet  milijuna piksela za otkriće vezanja Higgsovog bozona na fermione i novih čestica na Velikom hadronskom sudarivaču]]></title_hr><title_en><![CDATA[Hundred twenty five Megapixels to discover Fermionic Higgs couplings and New Particles at the Large Hadron Collider]]></title_en><user_id>11164</user_id><user_firstLast_name>Vuko Brigljević</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2016-06</proposal_call><code>IP-2016-06-3321</code><acronim><![CDATA[HIGGS125]]></acronim><duration>12.06.2017 - 31.08.2022</duration><status>Završio</status><financ_value>129.975,45 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, </scie_field_hr><scie_field_en>Physics, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>19705, 19738, 28912, 864909, 1086, 864951, 29408, 864907, </team_members_id><team_members_names><![CDATA[Tatjana  Šuša, Dinko Ferenček, Andrey Starodumov, Devdatta Majumder, Krešimir Jakovčić, Matej Roguljić, Saswat Mishra, Bhakti Kanulal Chitroda, ]]></team_members_names><keywords_hr><![CDATA[Higgsov bozon, fermionska vezanja, Standardni model, nove čestice, identifikacija b kvarkova, piksel detektor, LHC]]></keywords_hr><keywords_en><![CDATA[Higgs boson, fermionic couplings, Standard model, new particles,  b tagging, pixel detector, LHC]]></keywords_en><summary_hr><![CDATA[Ulaskom u drugu fazu rada Velikog hadronskog sudarivača čestica (LHC) na CERN-u započelo je još jedno uzbudljivo razdoblje u istraživanju temeljnih gradivnih  elemenata tvari. Opažanjem čestice sa svojstvima Higgsovog bozona na LHC-u čini se da je potvrđeno jedno od središnjih predviđanja Standardnog modela (SM) fizike čestica.  Međutim, sva svojstva otkrivene čestice tek se trebaju precizno odrediti kako bi se potvrdilo da je ona uistinu Higgsov bozon predviđen Standardnim modelom.  Cilj projekta je proučavanje vezanja Higgsovog bozona s fermionima, koja su u SM-u odgovorna za mase kvarkova i leptona. Ova vezanja dopuštaju raspade  Higgsovog bozona u fermione.  Međutim, takvi raspadi još nisu opaženi. Cilj projekta je opažanje raspada Higgsovog bozona u par b kvarkova  te precizno mjerenje učestalosti ovog raspada koristeći sve podatke koji će se prikupiti detektorom CMS u drugoj fazi rada LHC-a. Neopažanje ovog raspada ili odstupanje učestalosti raspada od vrijednosti predviđenih SM-om ukazalo bi na postojanje fizike izvan SM-a što bi bilo od iznimne važnosti. Cilj projekta su i izravne potrage za novim česticama proučavanjem konačnih stanja s b kvarkovima.  Projekt također namjerava pridonijeti poboljšanju performansi detektora CMS boljom identifikacijom hadronskih mlazova koji nastaju hadronizacijom b kvarkova (b mlazovi). Unapređenju identifikacije b mlazova (B označavanje) ponajviše će doprinijeti instalacija nadograđenog silicijskog piksel detektora početkom 2017. Jedan od ciljeva projekta je optimizacija performansi identifikacije b mlazova koristeći svojstva nadograđenog detektora, s posebnim naglaskom na označavanje topologija u kojima su se dva vrlo energijska b mlaza spojila u jedan mlaz. To će ovisiti o dobroj integraciji nadograđenog piksel detektora u CMS mjerenja, te projekt također uključuje niz ciljeva vezanih uz poboljšanje performansi piksel detektora i rekonstrukcije događaja.]]></summary_hr><summary_en><![CDATA[With the start of the second running phase (Run 2) of the Large Hadron Collider (LHC) at CERN, the study of the fundamental constituents of matter has again entered an exciting time. The observation of a Higgs-like boson at the LHC seems to confirm a central prediction of the Standard Model (SM) of particle physics. All properties of the discovered particle need however to be accurately determined to establish whether the new particle is the Higgs boson predicted in the SM.The proposal aims at studying the couplings of the Higgs boson to fermions, which in the SM gives rise to masses of quarks and leptons. These couplings allow the Higgs boson to decay into fermions. No such decay has however been observed yet. This projects targets an observation of the Higgs boson decay into a pair of b quarks, and a precise measurement of this decay rate using the full dataset to be acquired by the CMS detector during Run 2. A lack of observation of this decay or a deviation of its rate from the SM expectation would point at the presence of physics beyond the SM and be of great significance. The project also aims at direct searches for new particles by studying final states with b quarks.The project also intends to contribute to the improved performance of the CMS detector by improving the identification of hadronic jets stemming from the hadronization of a b quark (b-jets). The identification of b-jets (B tagging) will in particular benefit from the installation of an upgraded silicon pixel detector in early 2017. One of the project goals consists in optimizing the B tagging performance using the features of the upgraded detector, with a special focus on the tagging of topologies in which two very energetic b-jets are merged in one so-called “fat jet”. This relies on a good integration of the upgraded pixel detector in the CMS measurements, and the project therefore also includes a set of objectives linked to the improvement of the pixel detector performance and reconstruction.]]></summary_en></project><project>
<id>4332</id><title_hr><![CDATA[Opterećenja vjetra i mora na energetske konstrukcije]]></title_hr><title_en><![CDATA[Wind and sea loads on energy structures]]></title_en><user_id>4960</user_id><user_firstLast_name>Hrvoje Kozmar</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2016-06</proposal_call><code>IP-2016-06-2017</code><acronim><![CDATA[WESLO]]></acronim><duration>01.04.2017 - 30.09.2021</duration><status>Završio</status><financ_value>132.324,64 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Strojarstvo, </scie_field_hr><scie_field_en>Mechnical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet strojarstva i brodogradnje]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Mechanical Engineering and Naval Architecture]]></institution_en><team_members_id>5118, 6437, 5584, 252, 13308, 17884, 19684, 19466, 19443, 25331, 29416, 862796, </team_members_id><team_members_names><![CDATA[Ivo Džijan, marko tomić, Ivan Ćatipović, Nikola Vladimir, Neven Hadžić, Andrija Buljac, Željko Večenaj, Mihael Cindori, Franjo Juretić, Danijel Bosnar, Petar Škvorc, Petar Golem, ]]></team_members_names><keywords_hr><![CDATA[Inženjerstvo vjetra, aerodinamika okoliša, vjetar i konstrukcije, opterećenja mora, vjetroturbina, pučinska konstrukcija, zračni tunel]]></keywords_hr><keywords_en><![CDATA[Wind engineering, environmental aerodynamics, wind and structures, sea loads, wind turbine, offshore structure, wind tunnel]]></keywords_en><summary_hr><![CDATA[Vjetroturbine i pučinske platforme su izložene ekstremnim vremenskim uvjetima uključujući djelovanje vjetra, mora i valova. Da bi se produljio njihov vijek trajanja i povećala učinkovitost nužno je pažljivo analizirati utjecaje opterećenja okoliša na te objekte i predložiti odgovarajuća inženjerska rješenja. Uočeno je da su opterećenja vjetra, valova i mora na pučinske energetske objekte prethodno uglavnom bila analizirana odvojeno. Također se aerodinamička opterećenja na vjetroturbine u blizini brdovite obale i otoka bitno razlikuju od opterećenja na ravnom terenu i otvorenoj pučini, a karakteristike mahovitih vjetrova su u velikoj mjeri nepoznate u inženjerskim krugovima. Uz modelska laboratorijska ispitivanja, važan alat predstavljaju i računalne simulacije, u kojima trenutno nije moguće adekvatno reproducirati karakteristike atmosferske turbulencije. Sukladno navedenom vrlo aktualne istraživačke teme su: a) karakterizacija ekstremnih opterećenja i odziva vjetroturbina i platformi istovremeno uzrokovanih vjetrom, valovima i morskim strujama, b) aerodinamička opterećenja vjetroturbina u blizini brdovitog terena, c) karakteristike turbulencije mahovitog vjetra bure u obliku prikladnom za inženjersko projektiranje konstrukcija, d) metodologija računalne simulacije atmosferskog graničnog sloja i primjena na proračun opterećenja vjetroturbina i platformi. Da bi se navedeni ciljevi u potpunosti ostvarili u radu će biti korištene napredne istraživačke metode uključujući mjerenja u prirodi, laboratorijske eksperimente, računalnu mehaniku i dinamiku fluida. Budući da se integralna opterećenja vjetra, valova i morskih struja na energetske konstrukcije u potpunosti mogu analizirati isključivo kroz suradnju različitih grana znanosti i tehnike, istraživačka grupa u okviru ovog projekta na jedinstveni način uključuje stručnjake iz područja strojarstva, građevine, meteorologije i pomorske tehnike.]]></summary_hr><summary_en><![CDATA[Wind turbines and offshore platforms are exposed to a harsh marine environment including wind, wave and sea current loads. To extend their lifetime and increase energy production, it is necessary to carefully analyze effects of environmental loads on those structures and suggest appropriate engineering solutions. In the past, wind, wave and sea loads on offshore energy structures were commonly studied separately. In addition, aerodynamic loads on wind turbines close to hilly coast and islands are considerably different than the loads on wind turbines in flat terrain and open sea, whereas transient wind characteristics are fairly unknown to engineers. In addition to laboratory experiments, computational simulations are valuable tools to determine wind and sea loads on wind turbines and platforms. An important drawback with this approach at the moment is that it is not possible to completely accurately simulate characteristics of atmospheric turbulence. Hence, very contemporary research topics are: a) characterization of extreme loads and response of wind turbines and platforms simultaneously induced by wind, waves and sea currents, b) aerodynamic loads on wind turbines in complex terrain, c) characteristics of bora wind turbulence in a form usable for engineering design of structures, d) computational simulation methodology for the atmospheric boundary layer and application on wind-turbine and platform loads. To achieve those goals, various advanced research tools will be used including field measurements, small-scale laboratory experiments, computational mechanics and fluid dynamics. As integral wind, wave and sea current loads on energy structures can be completely analyzed only in case different engineering/science disciplines are involved, the research group on this project uniquely includes experts from mechanical and civil engineering, meteorology and offshore engineering in a unique blend of disciplines.]]></summary_en></project><project>
<id>4339</id><title_hr><![CDATA[Optička svojstva heterostruktura dihalkogenida prijelaznih metala ]]></title_hr><title_en><![CDATA[Optical Properties of Transition Metal Dichalcogenide Heterostructures]]></title_en><user_id>13782</user_id><user_firstLast_name>Marko Kralj</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2016-06</proposal_call><code>IP-2016-06-3211</code><acronim><![CDATA[OhTMD]]></acronim><duration>01.03.2017 - 30.09.2021</duration><status>Završio</status><financ_value>127.712,52 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, </scie_field_hr><scie_field_en>Physics, </scie_field_en><institution_hr><![CDATA[Institut za fiziku]]></institution_hr><institution_en><![CDATA[Institute of Physics in Zagreb]]></institution_en><team_members_id>6225, 3090, 19987, 19881, 856049, </team_members_id><team_members_names><![CDATA[Nataša  Vujičić, Iva Šrut Rakić, Davor Čapeta, Borna Pielić, SHEIKH MUHAMMAD OBAIDULLA, ]]></team_members_names><keywords_hr><![CDATA[2D materijali, heterostrukture, optoelektronika, međudjelovanje slojeva, CVD sinteza, optički odziv]]></keywords_hr><keywords_en><![CDATA[2D materials, heterostructures, optoelectronics, interlayer coupling, CVD synthesis, optical response]]></keywords_en><summary_hr><![CDATA[Glavni cilj ovog projekta je razviti razumijevanje efekata međudjelovanja između slojeva u heterostrukturama dvodimenzionalnih (2D) dihalkogenida prijelaznih metala (TMD) i upotrijebiti te spoznaje za formiranje struktura i uređaja sa željenim optičkim svojstvima. Intrinzična poluvodička priroda TMD slojeva, direktni procjep u limitu debljine jednog sloja, te potisnuto zasjenjenje u atomski tankom materijalu, čine ove materijale idealnim građevnim jedinicama  za razvoj raznolikih optoelektroničkih primjena, primjerice foto-detektora i foto-dioda, LED dioda i fotonaponskih ćelija. Strategija u provođenju sistematske analize interakcija slojeva bazira se na jedinstvenom uređaja za depoziciju iz kemijskih para (CVD) sa in situ mikroskopskim optičkim pristupom. CVD rast vertikalnih heterostruktura provodit će se u više koraka. Istovremeno sa direktnom sintezom, pripremat ćemo heterostrukure pomoću mehaničkog transfera slojeva, kako bi usporedili njihovu kvalitetu sa CVD uzorcima. Velika pažnja posvetit će se nano-strukturnoj karakterizaciji uzoraka pomoću mikroskopija skenirajućom probom, kako bi se identificirali defektikoji utječu na transport naboja i lokalna optička svojstva. Testirat će se optička svojstva s obzirom na interkalaciju materijala između slojeva što je vezano s promjenama u optičkom odgovoru i mogućim strukturnim promjenama zbog polimorfne prirode TMD. Odabrane heterostrukture biti će kontaktirane u uređaje kako bi se uvela dodatna mogućnost mijenjanja optičkih svojstva.Glavni eksperimentalni napor u ovom projektu usmjerit će se na razvoj postava za mjerenje optičkog odziva putem refleksije, fotoluminiscencije i Ramanove spektroskopije. Mjereni optički odaziv biti će direktno koreliran sa jačinom međudjelovanja između slojeva u heterostrukturama. Optički odziv mjerit će se i u pump-probe eksperimentima.]]></summary_hr><summary_en><![CDATA[The main goal of this project is to understand the effects of interlayer coupling in heterostructures of two-dimensional (2D) semiconducting transition metal dichalcogenides (TMDs) and use this knowledge to form structures and devices with desired optical response. The intrinsic semiconducting character of many TMDs, direct band gap in monolayer limit and suppressed screening effect in atomically thin form, makes these materials ideal building blocks for developing optoelectronic applications, including photodetectors, photodiodes, light-emitting devices, and photovoltaic cells. The strategy for performing systematic study of interlayer coupling is based on our unique capability to observe the chemical vapor deposition (CVD) growth process in situ by optical microscopy. The setup will be exploited in the multistep CVD growth of vertical heterostructures. Parallel to direct synthesis we will also form heterostructures by mechanical transfer in order to compare its quality to CVD growth. Great care will be also dedicated to nano-scale structural characterization of heterostructures, where scanning probe microscopy will be used to identify defects which affect charge transport and local optical response of the structures. We will test optical response regarding intercalation into the heterostructure interface, which is related to local modification of the optical response and possible structural changes caused by polymorphic nature of TMDs. We will contact selected individual heterostructures allowing us further degree of freedom in the control of the optical response. The major experimental effort in this project will be a development of capabilities to measure specific optical response via reflectivity, photoluminescence and Raman spectroscopy measurements. The optical response measurements will be directly correlated to the interlayer coupling in heterostructures. The optical response will be also investigated by pump-probe measurements.]]></summary_en></project><project>
<id>4343</id><title_hr><![CDATA[Klimatske promjene i invazivne vrste – utvrđivanje utjecaja na bioraznoliost nativnih slatkovodnih rakova i pastrva i njihova konzervacija]]></title_hr><title_en><![CDATA[Climate change and invasive species – assessing effects onto biodiversity of native freshwater crayfish and salmonids and their conservation ]]></title_en><user_id>12634</user_id><user_firstLast_name>Ivana Maguire</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2016-06</proposal_call><code>IP-2016-06-2563</code><acronim><![CDATA[CLINEinBIOta]]></acronim><duration>01.03.2017 - 30.09.2021</duration><status>Završio</status><financ_value>103.033,03 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Biologija, </scie_field_hr><scie_field_en>Biology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>1292, 11179, 7664, 19951, 4269, 19943, 12871, 25076, 25082, 25092, 25329, </team_members_id><team_members_names><![CDATA[Marina Piria, Martina Temunović, Goran Klobučar, Ana Tošić, Martina Podnar Lešić, Predrag Simonović, Sanja Gottstein, Andrea Rezić, Ivan Špelić, Tamara Kanjuh, Leona Lovrenčić, ]]></team_members_names><keywords_hr><![CDATA[genetska varijabilnost, evolucijska povijest, Astacus astacus, Austropotamobius torrentium, Salmo trutta, modeli pogodnosti staništa]]></keywords_hr><keywords_en><![CDATA[genetic variability, evolutionary history, Astacus astacus, Austropotamobius torrentium, Salmo trutta, habitat suitability models]]></keywords_en><summary_hr><![CDATA[Slatkovodni su ekosustavi pod sve većim antropogenim pritiskom što negativno utječe na njihovu bioraznolikost, a time i na njihovo funkcioniranje te usluge koje pružaju. Bioraznolikost posebice ugrožavaju globalne klimatske promjene i unos stranih vrsta. Stoga je cilj ovog projekta istražiti njihov utjecaj na slatkovodne organizme. U fokusu predloženog projekta su tri slatkovodne zavičajne vrste (potočni i plemeniti rak, potočna pastrva) koje imaju ključnu ulogu u ekosustavima, osiguravaju njihovo normalno funkcioniranje (rakovi) i ekonomski su značajne (pastrve). Njihov nestanak iz staništa značajno mijenja slatkovodne ekosustave, dovodi do promjena u dinamici transporta sedimenta te uzrokuje promjene u sastavu zajednica. Ove su vrste osjetljivi na promjene u staništu, a zbog negativnog antropogenog utjecaja i sve izraženijih klimatskih promjena, ugrožene su i zaštićene međunarodnim i nacionalnim zakonima.Cilj predloženog projekta je istražiti genetsku varijabilnost odabranih populacija ove tri vrste upotrebom mitohondrijskih, nuklearnih i mikrosatelitnih DNA biljega i doprinijeti novim spoznajama o njihovoj evolucijskoj povijesti i nasljeđu te identificirati njihove evolucijski bitne jedinice i jedinice upravljanja. Isto tako cilj je razviti modele potencijalno pogodnih područja za invazivne vrste rakova i strane linije pastrva kako bismo mogli predvidjeti područja i zavičajne populacije koja će biti pod njihovim najvećim pritiskom u budućnosti. Nadalje, cilj je izraditi modele pogodnosti staništa za proučavane zavičajne vrste, te njihova projekcija u budućnost prema različitim scenarijima klimatskih promjena što će omogućit identifikaciju područja koja će biti izrazito nepogodna za njihovo preživljavanje, kao i područja koja će osigurati njihov dugotrajni opstanak. Očekujemo da će dobiveni rezultati poslužiti kao kvalitetna osnova za izradu adekvatnih konzervacijskih strategija i planova upravljanja s ove tri osjetljive i ključne vrste slatkovodnih ekosustava. ]]></summary_hr><summary_en><![CDATA[Freshwater ecosystems are under growing anthropogenic pressure that negatively influence onto their biodiversity, and consequently onto alteration of ecosystem processes and impairment of ecosystem services. Nowadays, climate change and introduction of non-native species are recognised as one of the main factors of freshwater biodiversity loss. Therefore, objective of this project is to study their influence onto freshwater organisms. In the focus of the proposed project are three freshwater native species (stone and noble crayfish, brown trout) that have key role in the ecosystems; crayfish ensuring their normal functioning and trout being economically important.  Their disappearance from a habitat significantly alters freshwater ecosystem processes, species abundance and diversity. These three species are highly sensitive to habitat alteration, and due to negative human impacts onto their habitats and pronounced climate changes, they are vulnerable and protected by international and national legislation. The purpose of proposed project is to study genetic variability of different populations of these three species using mitochondrial, nuclear and microsatellite DNA markers, aiming to bring new insight into their evolutionary history and to identify their evolutionary significant and management units. Further, the aim is to develop habitat suitability models for non-native invasive crayfish species and allochthones trout lineages that would enable us to foresee areas that will be under biggest pressure in the future. Also, the aim is to develop habitat suitability models for native species future distribution under climate change scenarios that will enable us to identify areas, which will be unsuitable for their survival as well as areas that will ensure their long-term survival. We expect that obtained results will serve as a sound base for development of conservation strategies and management plans for these three vulnerable freshwater species.]]></summary_en></project><project>
<id>4344</id><title_hr><![CDATA[Relevantnost hermeneutičkog prosuđivanja]]></title_hr><title_en><![CDATA[Relevance  of Hermeneutical Judgment ]]></title_en><user_id>4842</user_id><user_firstLast_name>Jure Zovko</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2016-06</proposal_call><code>IP-2016-06-5672</code><acronim><![CDATA[RHJ]]></acronim><duration>01.03.2017 - 31.10.2021</duration><status>Završio</status><financ_value>34.507,93 eur</financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Filozofija, Filologija, </scie_field_hr><scie_field_en>Philosophy, Philology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zadru]]></institution_hr><institution_en><![CDATA[University of Zadar]]></institution_en><team_members_id>5236, 5387, 5379, 5660, 5375, </team_members_id><team_members_names><![CDATA[Marie-Elise Zovko, Ante Periša, Ljubiša Prica, Marko  Vučetić, Nives Delija Trešćec, ]]></team_members_names><keywords_hr><![CDATA[Hermeneutika, prosudba, interpretacija, razumijevanje, um, humanistika]]></keywords_hr><keywords_en><![CDATA[Hermeneutics, Judgment, Interpretation, Understanding, Reason, Humanities]]></keywords_en><summary_hr><![CDATA[Primarna intencija ovog planiranoga istraživanja jest pokazati da je hermeneutička prosudba integralni dio teorije razumijevanja i interpretacije. Tradicionalno, strogo metodološko razlikovanje između prirodnih i humanističkih znanosti posve je neodrživo (W. Dilthey, M. Heidegger, Charles Percy Snow, Hans-Georg Gadamer). Razumijevanje nije samo obilježje humanističkih znanosti, nego je također krucijalni segment prirodnih i tehničkih znanosti. Svrha prijavljenoga istraživačkoga projektnoga prijedloga jest razmotriti hermeneutičku metodologiju u kontekstu suvremenih promjena paradigma i pragmatičnoga zaokreta s posebnim osvrtom na filozofiju. Primarno ćemo se usredotočiti na relevantnost prosuđivanja u procesu razumijevanja i na hermeneutičku interpretaciju te pokazati da postupak razumijevanja ne podrazumijeva samo rekonstrukciju stvaralaštva duha, nego također njegovu prosudbu, vrjednovanje i sustavnu analizu.Uspješno kultiviranje sposobnosti prosuđivanja podrazumijeva stručnu kompetentnost i sposobnost refleksivne analize svega onoga što predstavlja stvaralaštvo ljudskoga duha, kulturnu baštinu. Na primjeru analize filozofskih djela kao što su Kantova Kritika moći suđenja, Wittgensteinovi kasni spisi,  te suvremene recepcije Hegelove praktične filozofije (Pippin, Brandom, McDowell, Honneth) razmotrit ćemo u kojoj je mjeri  kultiviranje duha preduvjet za uspješnu interpretaciju i prosudbu stvaralačkoga djela, kao i za kritičko suočavanje s postojećim formama kulturnoga i društvenoga životnoga svijeta te svega onoga što predstavlja interpretandum. U tom kontekstu kultiviranja ljudskoga uma i prosudbe razmotrit ćemo zahtjevnu ulogu i zadaću obrazovanja. ]]></summary_hr><summary_en><![CDATA[The proposal’s primary intention is to show that hermeneutical judgment is an integral part of the theory of understanding and interpretation. The traditional strict methodological distinction between the natural sciences and the humanities (Dilthey, Heidegger, Snow, Gadamer) is no longer acceptable.  Understanding is not only a feature of the humanities, but also a crucial segment of the natural sciences and engineering.Our aim is to examine hermeneutical methodology in the context of changing paradigms and the pragmatic turn, in particular with regard to philosophy. Primarily, we will focus on the relevance of judgment in the process of understanding, interpretation and explanation. In this context, we will show that the process of understanding presupposes not only a reconstruction of the products of human intelligence and creativity, but also their judgment, evaluation, and systematic analysis. The successful cultivation of judgement requires informed competence and the capacity for reflective analysis of higher-level manifestations of the human spirit which form the content of our cultural heritage and whose interpretation forms the specific task of the humanities. On the basis of analysis of works such as Kant&#39;s Critique of Judgment, Wittgenstein’s late works, and contemporary interpretation of Hegel’s practical philosophy (Pippin, Brandom, McDowell, Honneth) the project will investigate to what extent cultivation of mind is a precondition for successful interpretation and judgment of, as well as for critical confrontation with, forms of cultural and social production. We will consider to what extent understanding in the humanities presupposes the reflective capacity of judgment and in what manner study of content and topics from the humanities contributes to cultivation and sharpening of the ability to judge, evaluate and comprehend the intepretandum. In the context of the analysis of judgment we will consider the role and task of education.]]></summary_en></project><project>
<id>4346</id><title_hr><![CDATA[Koherencija pisanoga teksta u inome jeziku: hrvatski, njemački, engleski, francuski i mađarski jezik u usporedbi]]></title_hr><title_en><![CDATA[Textual Coherence in Foreign Language Writing: Croatian, German, English, French and Hungarian in Comparison]]></title_en><user_id>19861</user_id><user_firstLast_name>Vesna  Bagarić Medve </user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2016-06</proposal_call><code>IP-2016-06-5736</code><acronim><![CDATA[KohPiTekst]]></acronim><duration>01.03.2017 - 30.06.2020</duration><status>Završio</status><financ_value>38.977,11 eur</financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Filologija, </scie_field_hr><scie_field_en>Philology, </scie_field_en><institution_hr><![CDATA[Sveučilište Josipa Jurja Strossmayera u Osijeku, Filozofski fakultet]]></institution_hr><institution_en><![CDATA[Josip Juraj Strossmayer University of Osijek, Faculty of Humanities and Social Sciences]]></institution_en><team_members_id>19851, 19842, 19853, 20085, 19014, 19841, 20102, 19838, 19925, 20015, 7052, 4220, 25365, 25368, 25353, 25369, </team_members_id><team_members_names><![CDATA[Višnja Pavičić Takač, Leonard Pon, Draženka Molnar, Sanja Cimer, Ninočka Truck Biljan, Ana Mikić Čolić, Ivana Trtanj, Vedrana Berlengi, Beatrix Oszko, Milica Sabo, Lidija Cvikić, Antonia Ordulj, Vlatka Ivić, Manuela Karlak, Ivana Šarić Šokčević, Zoltan Medve, ]]></team_members_names><keywords_hr><![CDATA[koherencija teksta, metoda analize koherencije teksta, kohezija, strategije, prvi jezik, ini jezik ]]></keywords_hr><keywords_en><![CDATA[textual coherence, method for analysis of textual coherence, cohesion, strategies, first language, foreign language]]></keywords_en><summary_hr><![CDATA[Koherencija je prema brojnim primijenjenim lingvistima ključna komponenta diskursne kompetencije, uz koju se, međutim, veže niz otvorenih problema za čije je rješavanje potrebno sustavno empirijsko istraživanje. Istraživanje u okviru projektnoga prijedloga bavi se opisom i usporedbom obilježja i načina postizanja koherencije u tekstovima korisnika hrvatskoga, njemačkoga, engleskoga,  francuskoga i mađarskoga kao inoga jezika u usporedbi s obilježjima i načinom postizanja koherencije u tekstovima na njihovom materinskom jeziku. U skladu s tim, u istraživanju će se analizirati obilježja koherentnosti teksta korisnika inoga jezika, kao i čimbenici koji utječu na (ne)koherentnost teksta u inome jeziku. Također, analizirat će se povezanost uporabe kohezivnih sredstava i razine koherentnosti teksta u inome jeziku. Nadalje, ispitat će se postojanje razlika u obilježjima i načinima postizanja koherentnosti teksta s obzirom na osobna obilježja korisnika inoga jezika (spol, obrazovni profil, razina jezičnoga znanja, formalni i neformalni kontekst ovladavanja inim jezikom) i vanjske čimbenike (način na koji nastavnik konceptualizira koherenciju). Konačno, ispitat će se strategije koje korisnici inoga jezika upotrebljavaju u svrhu postizanja koherentnosti teksta.Ispitanike u istraživanju činit će 290 studenata iz četiriju država (iz Hrvatske, Mađarske, Njemačke i Velike Britanije) te 40 edukatora koji su učitelji spomenutih jezika ili djeluju kao procjenjivači ispita pisanja na navedenim jezicima. U svrhu prikupljanja podataka koristit će se metoda testiranja, metoda anketiranja, metoda intervjuiranja te metoda glasnog navođenja misli. Prikupljeni podatci analizirat će se primjenom metode analize koherencije teksta, korpusnolingvističke metode i statističke metode.Predloženo je istraživanje interdisciplinarnoga karaktera. Uz tekstnu i primijenjenu lingvistiku polazi od teorijskih i empirijskih spoznaja psiholingvistike, pragmatike, diskursne i korpusne analize. ]]></summary_hr><summary_en><![CDATA[According to many applied linguists, coherence is a key component of discourse competence. The concept of coherence is, however, related to the whole range of open problems. A systematic empirical investigation is needed to address those problems.   The research within this project proposal deals with the description and comparison of coherence features and the ways of developing coherence in texts written by foreign language learners of German, English, Hungarian, French, and Croatian compared to coherence properties and the ways of developing textual coherence in their respective mother tongues. The proposed research project will analyse coherence features of texts written by foreign language learners as well as factors responsible for (in)coherence in foreign language texts. It will also examine the interrelation between the use of cohesive devices and the level of textual coherence in a foreign language. Furthermore, it will investigate the possible differences in coherence properties and the ways of achieving coherence with regard to several personal traits of foreign language users as well as some external factors. Finally, the strategies employed by foreign language users for developing textual coherence will be examined.The participants in the research will be 290 students from Croatia, Hungary, Germany, and Great Britain as well as 40 educators working as teachers and/or raters of tests written by learners of the abovementioned languages. In the research, the data will be gathered using the following instruments and methods: language tests, surveys, interviews and a think-aloud protocol. The data will be analysed using the method of analysing textual coherence, methods of corpus linguistics and statistical methods. The proposed project is highly interdisciplinary; it is grounded in the theoretical and empirical findings in the area of applied linguistics, text linguistics, psycholinguistics, pragmatics, discourse and corpus linguistics. ]]></summary_en></project><project>
<id>4351</id><title_hr><![CDATA[Željeznodobni ženski identiteti u južnom dijelu Karpatske kotline]]></title_hr><title_en><![CDATA[Iron Age Female Identities in the Southern Carpathian Basin]]></title_en><user_id>7071</user_id><user_firstLast_name>Marko Dizdar</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2016-06</proposal_call><code>IP-2016-06-1749</code><acronim><![CDATA[FEMINE]]></acronim><duration>01.04.2017 - 30.09.2021</duration><status>Završio</status><financ_value>78.903,71 eur</financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Arheologija, </scie_field_hr><scie_field_en>Archeology, </scie_field_en><institution_hr><![CDATA[Institut za arheologiju]]></institution_hr><institution_en><![CDATA[Institute of Archaeology in Zagreb]]></institution_en><team_members_id>19335, 19103, 19809, 3432, 19659, 19792, 7022, 19091, 3646, 25275, 21180, </team_members_id><team_members_names><![CDATA[Saša Kovačević, Marija Ljuština, Aleksandar Kapuran, Hrvoje Potrebica, Asja Tonc, Mathias Mehofer, Metzner-Nebelsick Carola, Aurel Rustoiu, Daria Ložnjak Dizdar, Julia Katarina Kramberger, Antonela Barbir, ]]></team_members_names><keywords_hr><![CDATA[željezno doba, žene, identitet, Karpatska kotlina, nošnja, nakit, grobovi, groblja, rod, funkcionalna analiza, bioarheologija]]></keywords_hr><keywords_en><![CDATA[Iron Age, females, identity, Carpathian Basin, costume, jewellery, graves, cemeteries, gender, functional analysis, bioarchaeology]]></keywords_en><summary_hr><![CDATA[Cilj predloženoga projekta o razdoblju željeznoga doba, poduzetoga od strane arheologije u suradnji s antropološkim i arheometalurškim istraživanjima, naglasak stavlja na proučavanje različitih aspekata željeznodobnih (ŽD) ženskih društvenih identiteta koji se jedino mogu rekonstruirati iz arheoloških podataka. U projektu je predviđeno istraživanje zajedničkih modela, uz korištenje trenutnih interdisciplinarnih mogućnosti, koji se odnose na proučavanje rodnoga koncepta, što će predstavljati inovativnu aktivnost i značajan napredak u istraživanju ŽD zajednica u južnom dijelu Karpatske kotline (KK). Ženski identitet sastavljen je od višestrukih značajki koje su združene kako bi stvorile individualnu osobnost. Za vrijeme života pojedinac ima različite društvene identitete, čak i po nekoliko u isto vrijeme. Žene za vrijeme ŽD u južnom dijelu KK postaju posebno vidljive na osnovi arheoloških nalaza koji pokazuju razvoj brojnih karakterističnih predmeta. Naše trenutne spoznaje o položaju i ulozi žena većinom potječu iz istraživanja groblja koja nude prilično točnu sliku o svakodnevnom životu ŽD zajednica. Za vrijeme ŽD u KK uobičajeno je kako su pokojnice bile pokopane u svakodnevnoj nošnji i s osobnim nakitom koji se, s nalazima pršljena, smatraju kao iznimno jasan rodni prikaz. Projekt predstavlja kompleksnu studiju poznatih ŽD ženskih pokopa sa šest groblja u promatranom području na osnovi roda, dobi i grobnih priloga koje mogu obogatiti naše spoznaje o ŽD društvu na mnogo načina, pri čemu se posebna pažnja posvećuje funkcionalnoj analizi kombinacija u grobovima koje prikazuju različite lokalne ŽD zajednice te  višestruke identiteta jedne osobe. Funkcionalna analiza, odnosno kako su različiti elementi nošnje i nakita organizirani i udruženi u različite kombinacije, pruža pouzdane podatke o načinima koje su različiti pojedinci i/ili zajednice odabirali kako bi vizualno prikazali vlastite identitete i društvene odnose.]]></summary_hr><summary_en><![CDATA[Aim of proposed Iron Age project, conducted by archaeology in collaboration with anthropological and archaeometallurgical researches, is emphasis placed on the study of different aspects of the Iron Age (IA) female social identities which only can be reconstructed from the archaeological records. In this project is planning to explore common models, with the use of current interdisciplinary possibilities, in the field of gender concept which will be innovative activity and significant improvements in exploring of IA communities in the southern Carpathian Basin (CB). Female identity is composed of multiple features that are connected together to create an individual personhood. During a lifetime an individual has various social identities, even several at the same time. Females during the IA in the southern CB become increasingly visible in the archaeological record through the development of numerous characteristic accessories. Our present knowledge about position and role of women comes mostly from cemeteries which offer a fairly accurate picture of the everyday life of the IA communities. During the IA in the CB was a standard for the deceased to be buried in the everyday costume and with personal jewellery which, with spindle whorls, are remarkably sharp gender outfits. A project represent a complex study of the known IA female burials from six cemeteries in define region in terms of gender, age and grave goods which can enrich our knowledge of the IA society in many ways, with special attention to the functional analysis of the grave assemblages which reflects different local IA communities and shared identities of single persons. Functional analysis, the manner in which different costume and jewellery elements are composed and associated in various assemblages, provides relevant information regarding the ways in which various individuals and/or different communities chose to visually express their identities and social relationships.]]></summary_en></project><project>
<id>4352</id><title_hr><![CDATA[Cas3 kao kontrolna točka obrane CRISPR-Cas: razjašnjenje  njegove regulacije istraživanjem stabilnosti proteina i prepisivanja u bakteriji Escherichia coli]]></title_hr><title_en><![CDATA[Cas3 as a key checkpoint for CRISPR-Cas immunity: elucidating its regulation via protein stability and transcriptional control in Escherichia coli]]></title_en><user_id>4503</user_id><user_firstLast_name>Ivana Ivančić Baće</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2016-06</proposal_call><code>IP-2016-06-8861</code><acronim><![CDATA[Cas3 status]]></acronim><duration>01.03.2017 - 31.08.2021</duration><status>Završio</status><financ_value>125.091,25 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Biologija, Kemija, </scie_field_hr><scie_field_en>Biology, Chemistry, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>19376, 5173, 22812, 25303, </team_members_id><team_members_names><![CDATA[Kristina Majsec, Edward  Bolt Bolt, Marin Radovčić, Damjan Mitić, ]]></team_members_names><keywords_hr><![CDATA[CRISPR-Cas, Cas3, E. coli, RecBCD, HNS]]></keywords_hr><keywords_en><![CDATA[CRISPR-Cas, Cas3, E. coli, RecBCD, HNS]]></keywords_en><summary_hr><![CDATA[Clustered regularly interspaced short palindromic repeats (CRISPR) i CRISPR-associated (Cas) proteini sačinjavaju adaptivni imunološki sustav bakterija i arheja u borbi protiv virusa i plazmida. Ovaj sustav temelji se na ugradnji kratkih fragmenata strane DNA (razmaknice) u regiju CRISPR procesom koji se zove adaptacija. Ugrađene razmaknice služe za pamćenje prethodnih infekcija. U bakteriji Escherichia coli poznata su dva načina adaptacije: naivna i pripremljena. Tijekom naivne adaptacije razmaknice se direktno uzimaju iz strane DNA, dok je u pripremljenoj adaptaciji neophodna već postojeća razmaknica koja stimulira ugradnju novih razmaknica iz iste strane DNA. Za oba načina adaptacije neophodni su proteini Cas1 i Cas2, dok su za pripremljenu adaptaciju još potrebni interferencijski kompleks Cascade i protein Cas3. Unatoč značajnom napretku u otkriću molekularnih mehanizama obrane sustavom CRISPR-Cas, detalji nastanka dvolančanih fragmenata DNA potrebnih za oba načina adaptacije nisu dovoljno poznati, a također je nedovoljno istražena i regulacija CRISPR-Cas interferencije. Za RecBCD smo mi i drugi pokazali da je potreban za pripremu i ugradnju razmaknice u naivnoj adaptaciji, a nedavno smo pokazali da je protein Cas3 ograničavajući faktor CRISPR-Cas interferencije u ovisnosti o temperaturi inkubiranja. To upućuje na mogućnost da postoji još jedna razina regulacije sustava CRISPR-Cas u bakteriji E. coli koju bismo željeli istražiti. Da bismo doznali više o proteinu Cas3, razlozima njegove neobične aktivnosti i ulogama u CRISPR-Cas adaptivnoj imunosti, ciljevi ovog projekta su a) razjasniti je li protein Cas3 reguliran na razini transkripcije i post-translacijski. b) Istražiti uloge proteina Cas3 i komponenti enzima RecBCD u izgradnji CRISPR imunosti (adaptaciji). Također bismo željeli istražiti jesu li uloge ovih proteina međusobno usklađene i povezane s drugim staničnim procesima uključenim u održavanje stabilnosti genoma.]]></summary_hr><summary_en><![CDATA[Clustered regularly interspaced short palindromic repeats (CRISPR) and CRISPR-associated (Cas) proteins constitutes an adaptive immune system in bacteria and archaea against viruses and plasmids. It is based on integration of short fragments of foreign DNA (spacers) into the CRISPR array in a process called adaptation that serves as a memory of prior infections. Two modes of adaptation have been reported in Escherichia coli type IE system: naive and primed. During the naive adaptation, the spacers are directly obtained from a foreign DNA source while in primed adaptation the pre-existing spacer is required to enable enhanced uptake of new spacers from the same foreign DNA. Both modes require Cas1 and Cas2 proteins, and primed adaptation additionally requires interference complex Cascade and Cas3 protein. Despite the significant progress on the molecular mechanisms of defence by the CRISPR-Cas systems, details about generation of DNA fragments needed for both modes of adaptation are not sufficiently known, or mechanisms of the regulation of the CRISPR-Cas interference. We and others have recently shown that RecBCD enzyme is involved in spacer preparation and integration for naive adaptation, and we have very recently shown that Cas3 is the limiting factor for CRISPR-Cas interference depending on the temperature of incubation. This suggests a possibility that additional level of regulation of the CRISPR-Cas interference exists in E. coli. To learn more about the Cas3 protein, explain its unusual activity and find out about its roles in CRISPR-Cas adaptive immunity, the aims of this project are a) to understand if Cas3 is regulated in E. coli transcriptionally and post-translationally. (b) Delineate the roles of RecB and RecBC components of RecBCD and Cas3 protein in building CRISPR immunity (adaptation). We would also like to understand if their roles are coordinated and linked to other host cell genome maintenance processes.]]></summary_en></project><project>
<id>4355</id><title_hr><![CDATA[Rasvjetljivanje onkogenih funkcija E6/E7 HPV-a na različitim anatomskim mjestima ]]></title_hr><title_en><![CDATA[Elucidating the HPV E6/E7 Oncogenic Functions at Different Anatomical Sites]]></title_en><user_id>15915</user_id><user_firstLast_name>Vjekoslav Tomaić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2016-06</proposal_call><code>IP-2016-06-2246</code><acronim><![CDATA[HPVHNC]]></acronim><duration>15.05.2017 - 14.05.2022</duration><status>Završio</status><financ_value>131.661,03 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>3627, 19310, 19200, 19168, 3949, 25278, 23946, 24275, 24996, 17772, </team_members_id><team_members_names><![CDATA[Jasminka Golubić Talić, Lawrence Banks, Miranda Thomas, Paola Massimi, Emil Dediol, Lucija Lulić, Dražan Butorac, Nathaniel Edward Bennett Saidu, Anamaria Đukić, Josipa Skelin, ]]></team_members_names><keywords_hr><![CDATA[HPV, Karcinom, Glava i Vrat, E6, E7]]></keywords_hr><keywords_en><![CDATA[HPV, Cancer, Head and Neck, E6, E7 ]]></keywords_en><summary_hr><![CDATA[Humani papiloma virusi (HPV) uzrokuju preko 600.000 novih slučajeva raka godišnje na različitim anatomskim mjestima. Najčešća sijela raka uzrokovanog HPV-om su anogenitalno područje te glava i vrat. Najvažniji tip tumora uzrokovan HPV-om je rak vrata maternice, koji je jedan od glavnih uzroka smrti od tumora žena diljem svijeta. HPV-i kodiraju dva onkoproteina, E6 i E7 koji su direktno odgovorni za tumorigenezu. Ovi onkoproteini ciljaju različite signalne puteve stanice domaćina vezane uz kontrolu staničnog ciklusa i apoptozu te su trajno potrebni za proces tumorigeneze. Ukoliko se bilo koji od njih prestane ispoljavati, dolazi do prestanka rasta transformiranih stanica. Stoga ovi proteini predstavljaju značajne mete za eventualne terapije, a detaljno razumijevanje molekularnih mehanizama njihovog funkcioniranja je od iznimne važnosti. U zadnjih nekoliko godina je zamijećen trend porasta učestalosti nekih od HPV-povezanih tipova tumora, pogotovo u regiji glave i vrata. Ovi tumori većinom sadrže HPV tip 16, a karakterizira ih relativno kraće vrijeme između infekcije i nastanka tumora u odnosu na anogenitalne tumore. Ovo upućuje na postojanje značajnih razlika u mehanizmima nastanka tumora na različitim anatomskim mjestima. Jedan od glavnih ciljeva ovog projekta će biti otkriti da li su spomenute razlike posljedica različitih interakcija virusa i domaćina u različitim anatomskim mjestima. ]]></summary_hr><summary_en><![CDATA[Human Papillomaviruses (HPVs) cause over 600,000 cancers annually. These occur at diverse anatomical sites, and include anogenital and head and neck (HN) cancers. Of these the most important is cervical cancer, which is the leading cause of cancer-related death in women in many parts of the world. HPVs encode two oncoproteins, E6 and E7 that are directly responsible for the development of HPV-induced malignancies. They do this cooperatively by targeting diverse cellular pathways involved in the regulation of cell cycle control and apoptosis. Most importantly, there is a continued requirement for E6 and E7 expression throughout tumourigenesis, with loss of either protein resulting in a cessation of transformed cell growth. Therefore these viral proteins represent excellent targets for therapeutic intervention and understanding the molecular mechanisms underlying their respective functions is critical for developing such antiviral therapies. In recent years there has been dramatic increase in the number of HPV-associated cancers at other anatomical sites, especially in the HN region. Cancers found in this area largely contain HPV-16 sequences and the time frame between initial infections and cancer progression is much shorter in comparison with the anogenital cancers, indicating potentially major differences in how these viruses induce cancer development at different anatomical sites. Determining if this is a reflection of different modes of virus-host interactions in these sites will be the main focus of this project.]]></summary_en></project><project>
<id>4361</id><title_hr><![CDATA[Istraživanje složenih multiferoičnih materijala pripravljenih metodama otopinske kemije ]]></title_hr><title_en><![CDATA[Solution chemistry routes towards complex multiferroic materials]]></title_en><user_id>11136</user_id><user_firstLast_name>Igor Đerđ</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2016-06</proposal_call><code>IP-2016-06-3115</code><acronim><![CDATA[SOLFERROMAT]]></acronim><duration>01.03.2017 - 31.10.2021</duration><status>Završio</status><financ_value>129.802,91 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, Fizika, </scie_field_hr><scie_field_en>Chemistry, Physics, </scie_field_en><institution_hr><![CDATA[Sveučilište Josipa Jurja Strossmayera u Osijeku, Odjel za kemiju]]></institution_hr><institution_en><![CDATA[Josip Juraj Strossmayer University of Osijek, Department of Chemistry]]></institution_en><team_members_id>3671, 3960, 13203, 3531, 2757, 19878, 3632, 19928, 25200, </team_members_id><team_members_names><![CDATA[Goran Štefanić, BERISLAV MARKOVIĆ, Brunislav Matasović, Tomislav Balić, Dajana Gašo-Sokač, Mirjana  Bijelić, Anamarija šTER, Zvonko Jagličić, Jelena Bijelić, ]]></team_members_names><keywords_hr><![CDATA[Multiferoici, telurati, volframati, metaloorganske mreže, struktura]]></keywords_hr><keywords_en><![CDATA[Multiferroics, Tellurates, Tungstates, Metal-organic framework, Structure]]></keywords_en><summary_hr><![CDATA[Kako su i feromagnetizam i feroelektricitet ključni u mnogim aspektima moderne tehnologije, zahtjevi za materijalima koji pokazuju oba svojstva predstavljaju značajnu fundamentalnu i tehnološku važnost. Ipak, kad se u jednofaznom materijalu pojavljuje dva ili više fero-uređenja, njihovo međudjelovanje može proizvesti novi učinak koji se manifestira kao električna polarizacija uslijed primjene magnetskoga polja ili, obratno, magnetizacija uslijed primjene električnog polja.Glavni je cilj projekta SOLFERROMAT dizajniranje tri nova tipa funkcionalnih multiferoičnih spojeva: i) metaloorganskih spojeva perovskitne strukture ABX3 (A = amin-kation, B = prijelazni metal, X = organski ligand)ii) hibridne organsko-anorganske perovskitne strukture ABX4 (A = amin-kation, B = prijelazni metal, X = halogeni element) iiii) kompleksnih dvostrukih ili pojedinačnih perovskita tipa A2B(Te/W)O6 ili A3B2(Te/W)O9 (A = laki dvovalentni metal, B = prijelazni metal).Principi moderne koordinacijske kemije koji uključuju sol-gel postupak, mehanokemiju i mehanokemiju potpomognutu otapalom bit će korišteni za dizajniranje novih materijala za pohranu podataka, poglavito za  spintronske uređaje. Pažljivo organizirani slijed sinteza, karakterizacija i mjerenja magnetskih, električnih i magnetoelektričnih svojstava omogućit će postizanje ovoga cilja.Predložena metodologija za karakterizaciju struktura i svojstava novih materijala jest sinergija tehnika korištenih u trima disciplinama: koordinacijskoj kemiji, fizici kondenzirane tvari i znanosti o materijalima.  Glavni je cilj projekta poboljšati istraživanje povezivanjem kristalnog inženjeringa s fizikom i kemijom materijala kako bi se otkrili materijali novih funkcionalnih multiferoičnih svojstava. ]]></summary_hr><summary_en><![CDATA[Since indeed both ferromagnetism and ferroelectricity are essential to many forms of modern technology the demand for materials displaying both properties is of a great fundamental and technological importance, however, when coexistence of two or more ferroic orders in single-phase material is found, and furthermore, intimately coupled, the coupling interaction could produce new effect which manifests itself as an appearance of an electric polarization upon applying a magnetic field, and the appearance of magnetization upon applying an electric field. The main objective of SOLFERROMAT proposal is the design of three novel types of functional multiferroic compounds: i) perovskite structured metal-organic frameworks ABX3 (A = amine cation, B = transition metal, X = organic ligand) ii) perovskite-like hybrid organic-inorganic structures ABX4 (A = amine cation, B= transition metal, X = halogen) and iii) complex double or single perovskites A2B(Te/W)O6 or A3B2(Te/W)O9 (A = light divalent metal, B = transition metal). Building principles of modern coordination chemistry including sol-gel route, mechanochemistry and solvent assisted mechanochemistry will be actively used to explore the fundamental potential of designing new solids for data storage, particularly for spintronic devices. Carefully organized sequence of synthesis, characterization, and magnetic, electric and magnetoelectric properties measurements will allow achieving this goal.The proposed methodology to characterize structure and properties of new materials is the synergy of techniques used in three disciplines: coordination chemistry, condensed matter physics and materials science. The main aim of the project is to enlarge research by introducing crystal engineering into the physics and chemistry of solids, in order to reveal materials with new functional multiferroic properties.]]></summary_en></project><project>
<id>4362</id><title_hr><![CDATA[Istraživanje uloge proteinske modifikacije ADP-ribozilacije kod bakterija]]></title_hr><title_en><![CDATA[Understanding the role of protein ADP-ribosylation modification in bacteria]]></title_en><user_id>1221</user_id><user_firstLast_name>Andreja Mikoč</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2016-06</proposal_call><code>IP-2016-06-4242</code><acronim><![CDATA[ADPRIBAC]]></acronim><duration>01.03.2017 - 30.09.2021</duration><status>Završio</status><financ_value>132.722,81 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Biologija, </scie_field_hr><scie_field_en>Biology, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>1193, 1208, 1225, 19653, 23286, 27438, </team_members_id><team_members_names><![CDATA[Helena Ćetković, Mirna Halasz, Bruna Pleše, Ivan Ahel, Petra Mikolčević, Andrea  Hloušek-Kasun, ]]></team_members_names><keywords_hr><![CDATA[ADP-ribozilacija, streptomiceti, antibiotici, ADP-ribozil-transferaze, ADP-ribozil-hidrolaze,  makrodomene]]></keywords_hr><keywords_en><![CDATA[ADP-ribosylation, Streptomyces, antibiotics, ADP-ribosyltransferases, ADP-ribosylhydrolases, macrodomains ]]></keywords_en><summary_hr><![CDATA[Post-translacijske modifikacije događaju se nakon biosinteze proteina, mijenjaju svojstva proteina te proširuju njihov funkcionalni repertoar i regulaciju. ADP-ribozilacija proteina je reverzibilna post-translacijska modifikacija u kojoj se adenozin difosfat (ADP)-ribozni dio iz nikotinamid-adenin-dinukleotida (NAD) prenosi na ciljni protein. To je evolucijski očuvan proces koji kontrolira važne stanične procese kod eukariota. ADP-ribozilacija je otkrivena i kod nekoliko vrsta bakterija, ali su njezina regulacija i fiziološka važnost kod bakterija vrlo slabo istražene. Trenutno dostupni podaci ukazuju na to da ADP-ribozilacija sudjeluje u regulaciji proizvodnje antibiotika u modelnoj bakteriji iz roda Streptomyces, S. coelicolor. Streptomiceti su uobičajene bakterije tla poznate kao glavni proizvođači velikog broja različitih prirodnih bioaktivnih spojeva, posebno antibiotika.U okviru ovog projekta ćemo identificirati i opisati proteine odgovorne za stavljanje i skidanje proteinske modifikacije ADP-ribozilacije kod bakterije S. coelicolor i razjasniti stanične i metaboličke putove koje ova modifikacija kontrolira. Razumijevanje procesa ADP-ribozilacije kod streptomiceta trebalo bi nam omogućiti bolju manipulaciju i kontrolu metabolizma kod ovih iznimno važnih industrijskih mikroorganizama. Zbog očuvanosti proteina uključenih u proces ADP-ribozilacije, nove spoznaje do kojih dođemo kroz ovaj projekt trebale bi biti primjenjive i na druge bakterijske vrste, a u nekim aspektima potencijalno i na ljude.]]></summary_hr><summary_en><![CDATA[Post-translational modifications of proteins are chemical modifications of proteins that happen after their biosynthesis. They control behavior of the proteins and expand their functional repertoire and regulation. Protein ADP-ribosylation is a reversible post-translational modification in which an adenosine diphosphate (ADP)-ribose moiety from nicotinamide adenine dinucleotide (NAD) is transferred to a target protein. This is an ancient and ubiquitous process which controls wide variety of important cellular functions in eukaryotes. ADP-ribosylation has been detected in several bacterial species, but its regulation and physiological relevance are very poorly understood in bacteria. Currently available data suggest that ADP-ribosylation is involved in regulation of antibiotic production in a model bacterium from Streptomyces genus, S. coelicolor. Streptomyces are common soil bacteria particularly important as the main natural producers of diverse bioactive compounds, especially antibiotics.In the framework of this project we will identify and characterize novel proteins that make and remove the protein ADP-ribosylation in S. coelicolor and elucidate its cellular and metabolic pathways controlled by this modification. Understanding this process in Streptomyces should enable us to improve manipulations and control metabolism of these extremely important industrial microorganisms. Due to the conservation of proteins involved in ADP-ribosylation process, the knowledge obtained through this project should be translatable to other bacterial species, but in some aspects also possibly to humans.]]></summary_en></project><project>
<id>4365</id><title_hr><![CDATA[EVOLUCIJA UPALNOG ARTRITISA U DJECE: ULOGA OSNAŽENOGA MUSKULOSKELETNOGA ULTRAZVUKA TE EPIGENETSKIH, PROTEINSKIH I DISBIOTIČKIH BIOMARKERA U RAZVOJU JUVENILNOG IDIOPATSKOG ARTRITISA]]></title_hr><title_en><![CDATA[EVOLUTION OF INFLAMMATORY ARTHRITIS IN CHILDREN: THE ROLE OF PDUS ASSESMENT AND EPIGENETIC, PROTEIN AND DYSBIOSIS BIOMARKERS IN JUVENILE IDIOPATHIC ARTHRITIS DEVELOPEMENT]]></title_en><user_id>4768</user_id><user_firstLast_name>Miroslav Harjaček</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2016-06</proposal_call><code>IP-2016-06-4771</code><acronim><![CDATA[childARTHRITISevolve]]></acronim><duration>01.04.2017 - 31.03.2021</duration><status>Prekinut</status><financ_value>119.175,23 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Kliničke medicinske znanosti, Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Clinical sciences, Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Klinički bolnički centar "Sestre Milosrdnice", Zagreb]]></institution_hr><institution_en><![CDATA[Clinical Hospital Center "Sestre Milosrdnice", Zagreb]]></institution_en><team_members_id>13667, 2978, 13115, 20080, 20296, 20204, 25390, </team_members_id><team_members_names><![CDATA[Lovro Lamot, Vedran Katavić, Andrea Tešija Kuna, Danica Vidović Juras, Suzana Ožanić Bulić, Mandica Vidović, Domagoj Buljan, ]]></team_members_names><keywords_hr><![CDATA[juvenilni idiopatski artritis, nediferencirani artritis, epigenetika, proteomika, disbioza, ultrazvuk, biomarkeri]]></keywords_hr><keywords_en><![CDATA[juvenile idiopathic arthritis, undifferentiated arthritis, epigenetics, proteomics, dysbiosis, ultrasound, biomarkers]]></keywords_en><summary_hr><![CDATA[Juvenilni idiopatski artritis (JIA) najčešća je reumatska bolest dječje dobi. Kako bi se spriječilo oštećenje zglobova te razvoj funkcionalne nesposobnosti, jedan od glavnih ciljeva u liječenju bolesti postao je rano postavljanje dijagnoze te odabir učinkovite i poštedne terapije. Nažalost, na samom početku bolesti trenutno je vrlo teško odrediti kako će bolest napredovati. Dosada je provedeno mnogo istraživanja koja su pokazala da u podlozi bolesti leži kompleksna disregulacija imunološkog sustava do koje dolazi zbog utjecaja genetskih i okolišnih čimbenika. Ipak, još smo daleko od jasne slike mehanizama koji predisponiraju dijete za razvoj bolesti, pogoršanje simptoma ili za dobar odgovor na pojedini oblik liječenja. Cilj ovoga projekta stoga je u krvi, stolici, slini i sinovijalnoj tekućini bolesnika otkriti različite epigenetske i proteinske biomarkere te odrediti vrijednost osnaženog muskuloskeletnog ultrazvuka (engl. power-doppler ultrasound) i različitih kliničkih pokazatelja u otkrivanju ranih promjena i predviđanju tijeka bolesti. U istraživanju će sudjelovati 17 bolesnika s nediferenciranim artritisom (NA) i 33 bolesnika s razvijenim JIA koji će biti praćeni tijekom dvije godine. U više vremenskih točaka ispitat će se epigenetski mehanizmi (metilacija, histonska modifikacija) regulacije ključnih čimbenika transkripcije i fosfataza koji se povezuju s razvojem bolesti te izražaj nekodirajućih RNA. Nadalje, u više navrata će se provesti i analize proteoma pomoću masene spektometrije, a odabrani proteini analizirati će se pomoću komplementarnih metoda. Rezultati ovog sveobuhvatnog projekta pružit će nam bolji uvid u kompleksne mehanizme u podlozi bolesti te otkriti potencijalne epigenetske, proteinske i disbiotičke biomarkere koji će nam omogućiti ranije postavljanje dijagnoze te bolje klasificiranje bolesti i predviđanje odgovora na liječenja. Naposljetku, dobiveni rezultati mogli bi nam omogućiti i otkrivanje novih načina liječenja ove nepredvidive bolesti.]]></summary_hr><summary_en><![CDATA[Juvenile idiopathic arthritis (JIA) is the most common childhood rheumatic disease. The early diagnosis of new-onset JIA has become a major objective for pediatric rheumatologists in order to identify a management strategy able to change the natural history of the disease and to prevent joint damage and functional impairment. The term undifferentiated arthritis (UA) is applied to the most common type of arthritis at the early stage when, in the absence of current recommended diagnostic criteria, it cannot be classified into the clinical subtypes of JIA. Patients with UA may progress towards JIA; however in some cases arthritis may completely resolve. Many studies has shown important role of immune system dysregulation influenced by genetic and environmental factors, but we are still far from having a clear picture of the molecular network that predisposes a child to develop the disease, to worsen the symptoms, or to successfully respond to a specific treatment. The goal of this project is to identify various epigenetic, protein and dysbiotic biomarkers in blood, stool, saliva and synovial fluid of 17 UA and 33 JIA patients, along with the value of power-doppler ultrasound (PDUS) and clinical assessment tools in the prediction of disease evolution. Therefore, we will analyze epigenetic modifications (methilatyon and histone modifications) of transcription factors and phosphatases with a known role in disease development, as well as microRNA expression profiles. Furthermore, to elucidate the possible role of other proteins, proteome will be analyzed by mass spectrometry, and selected proteins will be confirmed by complementary methods. The results of this comprehensive project will provide new insights into complex pathophysiology of JIA and enable us to use epigenetic, protein and dysbiotic biomarkers for better diagnosis, classification and treatment response prediction. In addition, results of the project may help to identify potentially new therapeutic targets.]]></summary_en></project><project>
<id>4369</id><title_hr><![CDATA[Molekularni mehanizam neurodegeneracije u Niemann-Pickovoj bolesti tip C]]></title_hr><title_en><![CDATA[Molecular mechanism(s) of neurodegeneration in Niemann-Pick type C disease]]></title_en><user_id>4828</user_id><user_firstLast_name>Silva Katušić Hećimović</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2016-06</proposal_call><code>IP-2016-06-2799</code><acronim><![CDATA[neuroNiPiC]]></acronim><duration>01.06.2017 - 30.04.2022</duration><status>Završio</status><financ_value>127.679,34 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>19545, 19703, 19821, 17865, 25337, 25281, 3095, </team_members_id><team_members_names><![CDATA[Sabina Tahirovic, Alessio Vittorio Colombo, Stefan  Lichtenthaler, Kristina Dominko, Lea Vidatić, Ana Rastija, Martina Deželjin, ]]></team_members_names><keywords_hr><![CDATA[Alzheimerova bolest, Aß, APP, BACE1, kolesterol, neurodegeneracija, neuroinflamacija, Niemann-Pickova bolest tip C, NPC1, tau]]></keywords_hr><keywords_en><![CDATA[Alzheimer’s disease, Aß, APP, BACE1, cholesterol, neurodegeneration, neuroinflammation, Niemann-Pick type C disease, NPC1, tau]]></keywords_en><summary_hr><![CDATA[Niemann-Pickova bolest tip C (NPC) je rijetka dječja progresivna neurodegenerativna bolest koju karakterizira nakupljanje kolesterola, gubitak Purkinjeovih neurona u cerebelumu, hiperfosforilacija proteina tau i značajna neuroinflamacija. Intrigantno je da ova rijetka nasljedna bolest (uzrokovana mutacijama u genu NPC1 ili NPC2) pokazuje niz značajki kompleksne Alzheimerove bolesti (AB). Međutim, ove neurodegenerativne bolesti pokazuju različitu „ranjivost“ regija mozga; hipokampus je primarno oštećen u AB, dok je pošteđen u bolesti NPC, a cerebelum je pošteđen u AB, dok je primarno zahvaćen u bolesti NPC. U ovom projektu ćemo primijeniti saznanja opsežnih istraživanja proteolitičke razgradnje proteina prekursora peptida amiloid-ß (APP) u najčešćoj neurodegenerativnoj bolesti AB s ciljem razumijevanja molekularnog mehanizam neurodegeneracije u rijetkoj bolesti NPC. Potaknuti našim nedavnim otkrićem da jedan od glavnih enzima AB ß-sekretaza (BACE1) povećano cijepa protein APP u bolesti NPC, ispitat ćemo ulogu proteolize enzimom BACE1 u patogenezi bolesti NPC i može li BACE1 predstavljati novu ciljnu molekulu za tretiranje/ublažavanje bolesti NPC. U hipokampusu i cerebelumu NPC1- i wt-miševa ispitat ćemo proteolizu i distribuciju APP kao i dva nedavno otkrivena isključiva supstrata za BACE1. Primarne kulture neurona hipokampusa i Purkinjeovih neurona cerebeluma ćemo upotrijebiti za otkrivanje mehanizma učinka BACE1 na patološke značajke NPC bolesti. Također, razvit ćemo ex vivo model bolesti NPC korištenjem organotipskih kultura moždanih rezova hipokampusa i cerebeluma te ćemo pratiti utjecaj inhibicije BACE1 na prevenciju/ublažavanje patoloških značajki bolesti NPC. Konačno, generirat ćemo mišji model NPC1 u kojem ćemo ukloniti gen BACE1 za potvrdu dobivenih rezultata in vivo. Ova istraživanja će ukazati na ulogu BACE1 u patogenezi NPC bolesti i na potencijalno ciljanje enzima BACE1 kao alternativnog pristupa liječenja ove još uvijek neizlječive bolesti.]]></summary_hr><summary_en><![CDATA[Niemann-Pick type C disease (NPC) is a rare childhood progressive neurodegenerative disorder characterized by cholesterol accumulation, the loss of Purkinje neurons in the cerebellum, hyperphosphorylation of tau and profound neuroinflammation. It is intriguing that this rare inherited disease (caused by mutations in NPC1 or NPC2 genes) shows several key features of a complex Alzheimer&#39;s disease (AD). However, these two neurodegenerative disorders show different regional vulnerabilities; hippocampus is the most affected region in AD and is spared in NPC disease, and the cerebellum is spared in AD but is primarily affected in NPC. In this project we will use the knowledge gained through extensive research on the processing of the ß-amyloid precursor protein (APP) in the most common neurodegenerative disease AD to elucidate molecular mechanism(s) of neurodegeneration in a rare disorder NPC. Based on our recent finding that proteolysis of APP by one of the key AD enzymes ß-secretase (BACE1) is enhanced in NPC, in this project we will elucidate the role of BACE1 in the pathogenesis of NPC and whether BACE1 may represent a novel target for treating/ameliorating NPC disease. We will analyze BACE1-proteolysis and distribution of APP and the two recently identified exclusive BACE1 substrates in hippocampus and cerebellum of NPC1- and wt-mice. Primary hippocampal and cerebellar Purkinje neuronal cultures will be used to dissect the mechanism(s) of the BACE1-mediated effect on pathological features of NPC. Also, we will develop an ex vivo model of NPC disease using hippocampal and cerebellar organotypic brain slices and will monitor whether BACE1-inhibition may prevent/ameliorate any of the NPC pathological features. Lastly, we will genetically deplete BACE1 in NPC1-mice to validate our findings in vivo. These studies may indicate a role of BACE1 in NPC pathogenesis and the potential of targeting BACE1 as an alternative approach for treating this devastating disease.]]></summary_en></project><project>
<id>4372</id><title_hr><![CDATA[Tipovi školske kulture i  učenje aktivnog građanstva: kritičko-interdisciplinarni pristup]]></title_hr><title_en><![CDATA[The Types of School Culture and Learning for Active Citizenship: Critical Interdisciplinary Approach]]></title_en><user_id>7887</user_id><user_firstLast_name>Vedrana Spajić-Vrkaš</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2016-06</proposal_call><code>IP-2016-06-5010</code><acronim><![CDATA[TaSC]]></acronim><duration>01.01.2017 - 31.12.2020</duration><status>Prekinut</status><financ_value>68.153,16 eur</financ_value><scie_area_hr>Društvene znanosti, Humanističke znanosti, </scie_area_hr><scie_area_en>Social sciences, Humanities, </scie_area_en><scie_field_hr>Pedagogija, Politologija, Sociologija, Etnologija i antropologija, Obrazovne znanosti, </scie_field_hr><scie_field_en>Pedagogy, Political Science, Sociology, Ethnology and anthropology, Educational sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Filozofski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Humanities and Social Sciences]]></institution_en><team_members_id>12964, 13252, 12864, 13233, 12830, 12926, 12924, 13059, 6817, 7274, 13048, 13103, 13579, 19948, </team_members_id><team_members_names><![CDATA[Elvi Piršl, Barbara Kušević, Ana Širanović, Neven Hrvatić, Ana Blažević Simić, Marija Bartulović, Tomislav Pletenac, Monika Rajković, Marija Sablić, Berto  Šalaj, Dorijan Vahtar, Izvor Rukavina, Benjamin Čulig, Ines Elezović, ]]></team_members_names><keywords_hr><![CDATA[tipovi kulture škole, učenje aktivnog građanstva, kritičko-interdisciplinarni pristup, kvantitativno istraživanje, kvalitativno istraživanje]]></keywords_hr><keywords_en><![CDATA[types of school culture, learning for active citizenship, critical interdisciplinary approach, quantitative research, qualitative research]]></keywords_en><summary_hr><![CDATA[Usprkos općem prihvaćanju teze da je pripremljenost građana za participaciju ključ demokratskog razvoja kao i domaćim istraživanjima koja potvrđuju nisku razinu političkog znanja i kulture učenika, hrvatske škole ni danas ne pripremaju za aktivno građanstvo. Inozemna iskustva potvrđuju da je takva priprema dugotrajan i složen proces čiji uspjeh ne ovisi samo o uvođenju građanskog obrazovanja u škole nego i o demokratičnosti školske kulture. O tome u velikoj mjeri ovisi hoće li učenici učiti o građanstvu ili za građanstvo i hoće li građansku ulogu shvaćati u terminima poslušnosti i dužnosti ili emancipacije i društvene odgovornosti. Međutim, povećanje interesa za to područje nije dovelo i do većeg broja odgovarajućih istraživanja, i to zato što se metodologija istraživanja školske kulture razvila iz teorije akademske učinkovitosti škole, kojoj se zamjera promicanje antidemokratskih školskih praksi. Suočeni s tim nedostacima, skupina hrvatskih istraživača izradila je instrument za ispitivanje percepcije školske kulture i došla do njihove tipologije po kriteriju demokratsko-nedemokratsko. S obzirom da ranija istraživanja nisu eksplicitno propitivala ulogu školske kulture u razvoju aktivnog građanstva, u ovom je projektu postavljen trostruki cilj: a. utvrditi koja obilježja školske kulture doprinose razvoju aktivnog građanstva; b. utvrditi jesu li ta obilježja međupovezana i strukturirana tako da vode izradi tipologije koja odgovara na pitanje zašto se neke škole uspijevaju a druge ne uspijevaju demokratizirati i c. predložiti kritičko-transformativni model demokratske školske kulture. Istraživanje će se provoditi u dvije faze. U prvoj, kvantitativnoj, primijenit će se anketni upitnici na reprezentativnom uzorku glavnih aktera obrazovanja. U drugoj, kvalitativnoj, pratit će se i opisati obilježja uspješne i neuspješne škole. Analiza i interpretacija bit će provedene prema standardima kritičko-interdisciplinarne perspektive. ]]></summary_hr><summary_en><![CDATA[Despite the generally accepted thesis that the preparation of citizens for participation is the key to developing democracy, and despite domestic studies that show a low level of students’ political knowledge and culture, Croatian schools do not prepare for active citizenship. Foreign experiences confirm that such preparation is a long-lasting and complex process. Its success does not depend solely on the introduction of citizenship education in schools but also on the democratization of school culture. This depends on whether the students will learn about or for citizenship and whether they will understand their citizen’s role in terms of obedience and duties or in terms of emancipation and social responsibility. However, the rise of interest in this field did not lead to more such studies, due to the research methodology based on academic school effectiveness theory, often criticized for promoting undemocratic school practices. Faced with such limitations, a group of Croatian researchers developed an instrument for studying school culture, which led to a school culture typology placed on the democratic-undemocratic continuum. Since earlier studies were not focused on the link between school culture and active citizenship, the present research has a three-fold goal: a. to identify the characteristics of school culture contributing to the development of active citizenship; b. to determine whether these characteristics are inter-linked and structured so as to allow the development of a typology to explain why some schools succeed and other fail to democratize, and c. to develop a critical transformative model of a democratic school culture. Research will be conducted in two phases: quantitative, in which questionnaires will be applied on a representative sample of main school actors, and qualitative, in which successful and unsuccessful school culture features will]]></summary_en></project><project>
<id>4377</id><title_hr><![CDATA[Zaštitni mehanizmi i učinci flavonoida ugrađenih u nanonosače u modelnim membranama i neuronima]]></title_hr><title_en><![CDATA[Protective mechanisms and effects of nano-delivered flavonoids in model cell membranes and neurons]]></title_en><user_id>423</user_id><user_firstLast_name>Suzana Šegota</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2016-06</proposal_call><code>IP-2016-06-8415</code><acronim><![CDATA[NanoFlavNeuroProtect]]></acronim><duration>15.04.2017 - 14.10.2021</duration><status>Završio</status><financ_value>126.875,04 eur</financ_value><scie_area_hr>Prirodne znanosti, Biomedicina i zdravstvo, </scie_area_hr><scie_area_en>Natural sciences, Biomedicine and health sciences, </scie_area_en><scie_field_hr>Biotehnologija u biomedicini, Kemija, Biologija, </scie_field_hr><scie_field_en>Biotechnology in Biomedicine, Chemistry, Biology, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>224, 339, 404, 336, 771, 5101, 3616, 19218, 25279, 25592, </team_members_id><team_members_names><![CDATA[Maja Dutour Sikirić, Darija Domazet Jurašin, Vida Čadež, Tea Mihelj, Goran Baranović, Josipa Vlainić, Martina Medvidović-Kosanović, Mislav Mustapic, Anja Sadžak, Lucija Mandić, ]]></team_members_names><keywords_hr><![CDATA[mikroskopija atomskih sila, modelne membrane, flavonoidi, nanočestice, neuroni, oksidativni stres, neurozaštita]]></keywords_hr><keywords_en><![CDATA[atomic force microscopy, model membranes, flavonoids, nanoparticles, neurons,  oxidative stress, neuroprotection]]></keywords_en><summary_hr><![CDATA[Flavonoidi, polifenolne biomolekule s antioksidativnom aktivnošću prepoznate su kao potencijalno novi terapeutici neurodegenerativnih bolesti. Osim što mehanizam antioksidativnog učinka flavonoida do danas nije u potpunosti razjašnjen, mogućnosti njihove terapeutske primjene smanjuje i slaba topljivost u vodi te kemijska nestabilnost pri fiziološkim uvjetima, koja se javlja prilikom primjene farmaceutskih proizvoda. Moguće rješenje je ugradnja flavonoida u nanočestice (NČ) kao nosače. Cilj predloženog projekta je riješiti problem slabe topljivosti u vodi i kemijske nestabilnosti dostavom flavonoida ugrađenih u NČ do modelnih membrana i neurona, čime bi se trebali poboljšati njihovi zaštitni učinci. Kako bi potvrdili primjenjivost ovog pristupa, u sklopu predloženog projekta istražit će se i interakcije između NČ i stanica, posebice membrana i NČ, jer su one od iznimne važnosti za unos u stanice i nanotoksičnost.Kao nano-nosači flavonoida koristit će se dvije vrste biorazgradivih mezoporoznih NČ, silike i getita. Mezoporozne magnetske Fe3O4 NČ su odabrane kao kontrolne NČ zbog dokazanih superiornih svojstava ugradnje i otpuštanja lijekova. Kombinacijom komplementarnih eksperimentalnih tehnika, koja do sada nije u potpunosti iskorištena u području nanobiotehnologije (mikroskopija atomskih sila, spektroskopija sila, infracrvena spektroskopija s oslabljenom totalnom refleksijom, dinamičko raspršenje svijetlosti, mikrokalorimetrija), predloženi projekt će u konačnici omogućiti detaljne informacije o utjecaju veličine, oblika, naboja i hidrofobnosti NČ s ugrađenim flavonoidima na modelne membrane i neurone, posebice u uvjetima oksidativnog stresa. Također, informacije o naboju te promjeni strukturnih i nanomehaničkih svojstava modelnih odnosno neuronskih membrana će omogućiti razvoj novih, poboljšanih terapeutika za neurološke poremećaje izazvane oksidativnim stresom.]]></summary_hr><summary_en><![CDATA[Flavonoids, polyphenolic biomolecules with antioxidative activity, have recently emerged as potential novel therapeutics for neurodegenerative diseases. In addition to the fact that the mechanisms of their antioxidant effects have not yet been fully elucidated, their applicability is rendered by poor water solubility and chemical instability under physiological conditions encountered during pharmaceutical product consumption. Flavonoid incorporation in nanoparticles (NPs) as carriers has been proposed as possible solution to surpass these obstacles. Therefore, the aim of the proposed project is to overcome the problem of poor water solubility and chemical instability of flavonoids by delivering them loaded in NPs to model membranes and neurons whereby their protective effects should be enhanced. In order to confirm usefulness of this approach, interactions between NPs and cells, in particular, membrane-NP interactions, will be determined since they are of crucial importance both for cell uptake and nanotoxicity.Two kinds of biodegradable mesoporous NPs, silica and goethite, will be investigated as flavonoid nanocarriers. Fe3O4 NPs were chosen as control due to their superior drug-loading and controlled release properties. By applying combination of complementary experimental techniques not yet fully exploited in the field of nanobiotechnology (atomic force microscopy, force spectroscopy, infrared spectroscopy with attenuated total reflection, dynamic light scattering, microcalorimetry), this project will ultimately generate detailed knowledge about the effects of the size, shape, charge and hydrophobicity of NPs loaded with flavonoids on model membranes and neurons, especially under oxidative stress conditions. In addition, information about the changes in structural and nanomechanical properties of model and neuronal membranes will pave the way towards development of novel and improved therapeutic solutions for oxidative stress-associated neurological disorders.]]></summary_en></project><project>
<id>4379</id><title_hr><![CDATA[Geoprostorno praćenje zelene infrastrukture na temelju terestričkih, zračnih i satelitskih snimaka]]></title_hr><title_en><![CDATA[GEospatial Monitoring of green INfrastructure by means of terrestrial, airborne and satellite Imagery]]></title_en><user_id>3207</user_id><user_firstLast_name>Damir Medak</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2016-06</proposal_call><code>IP-2016-06-5621</code><acronim><![CDATA[GEMINI]]></acronim><duration>01.03.2017 - 28.02.2021</duration><status>Završio</status><financ_value>131.528,30 eur</financ_value><scie_area_hr>Tehničke znanosti, Biotehničke znanosti, </scie_area_hr><scie_area_en>Technological sciences, Biotechnical sciences, </scie_area_en><scie_field_hr>Geodezija, Šumarstvo, </scie_field_hr><scie_field_en>Geodesy, Forestry, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Geodetski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Geodesy]]></institution_en><team_members_id>7009, 7421, 13129, 6589, 20306, 3478, 20160, 20328, 3272, 20341, 25463, 26389, </team_members_id><team_members_names><![CDATA[Ivan Pilaš, Silvija  Krajter Ostoić, Robert Župan, Dubravko Gajski, Mateo Gašparović, Mario Miler, Stanislav Frangeš, Vanja Miljković, Ela Vela , Andrija Krtalić, Mihael Galinac, Petar Božičević, ]]></team_members_names><keywords_hr><![CDATA[geoinformatika, zelena infrastruktura, fotogrametrija, daljinska istraživanja, geostatistika]]></keywords_hr><keywords_en><![CDATA[geoinformatics, green infrastructure, photogrammetry, remote sensing, geostatistics]]></keywords_en><summary_hr><![CDATA[Zelena infrastruktura je mreža prirodnih i izgrađenih područja, objekata i zelenih površina u ruralnom i urbanom prostoru koja omogućuje društvu održivo zdravo okružje za svakodnevni život. Satelitska daljinska istraživanja predstavljaju ključni izvor podataka za kartiranje takvih okružja, ali nisu dovoljna za njihovo potpuno razumijevanje, jer zelena infrastruktura također sadrži i vertikalne strukture kao što su zelene terase i balkoni koje nije moguće snimiti vertikalnim satelitskim opažanjima. Nijedan pojedinačni izvor podataka nije dovoljan kako bi se kvalitetno kartiralo, pratilo, modeliralo i na kraju razumjelo i upravljalo interakcijom s takvim urbanim sustavima. Beskontaktno snimanje uz pomoć bespilotnih letjelica značajno proširuje mogućnosti prikupljanja dodatnih informacija potrebnih za praćenje zelene infrastrukture unutar urbanih područja na brz i jednostavan način. Glavni cilj ovog istraživačkog projekta je u ispitivanju i uspostavi inovativnog, više­dimenzionalnog sustava praćenja urbane zelene infrastrukture, koji integrira najnovije mogućnosti pridobivanja statičkih i dinamičkih multispektralnih informacija (satelitske snimke, zračne i terestričke snimke), naprednih prostornih analiza sa svrhom unapređenja sustava upravljanja i odlučivanja o zelenim gradskim područjima. S obzirom na trenutno stanje i značaj istraživane problematike, očekivani rezultati projekta omogućit će značajno tehnološko i metodološko unapređenje sadašnjih sustava upravljanja ZI u Hrvatskoj i Europi. Područje istraživanja obuhvaća urbano područje grada Zagreba s naglaskom na zaštićena zelena područja. Istraživanje se temelji na geoprostornim tehnologijama i metodama: daljinska istraživanja i geoinformacijski sustavi omogućit će integraciju utemeljenu na standardima Otvorenog geoprostornog konzorcija. Klasifikacija, određivanje granica objekata i ostale metode daljinskih istraživanja bit će temeljene na terestričkim, zračnim i satelitskim multispektralnim snimkama.]]></summary_hr><summary_en><![CDATA[Green infrastructure (GI) is a network of natural and semi-natural areas, features and green spaces in rural and urban areas that collectively provide society sustainable healthy living environment. Satellite remote sensing technology provides a key data source for mapping such environments, but is not sufficient for fully understanding them, because GI also comprise vertical structures like green terraces and balconies that are not detectable by perpendicular satellite imagery. No single data source is sufficient to satisfy the information needs required to map, monitor, model, and ultimately understand and manage our interaction within such urban systems. Unmanned Aerial Vehicles (UAV) based remote sensing offers great possibilities to acquire field data for monitoring of GI within the urban areas in a fast and easy way. The main objective of this research project is to establish an innovative, multidimensional system for monitoring of urban green infrastructure, which integrates the latest means of data collection (multispectral satellite imagery improved and calibrated with high resolution terrestrial and airborne multispectral sources), advanced spatial analysis with the aim to improve decision support system for better management of urban GI. Taking in the account current state of the art and the importance of research topic, the results of the project will significantly improve the technology and methodology of current management techniques of GI in Croatia as well as Europe.The proposed study area is the urban area of the city of Zagreb with focus on protected green areas inside the city. The research will be based on geospatial technologies and techniques: Remote Sensing and GIS tools and recommend a holistic integration of these technologies within the language of Open Geospatial Consortium (OGC) standards. Classification, object detection and other remote sensing methods will be based on the terrestrial, airborne and satellite multispectral imagery.]]></summary_en></project><project>
<id>4380</id><title_hr><![CDATA[Procjena svakodnevne izloženosti metalima i osobne osjetljivosti majke kao čimbenika razvojnoga podrijetla zdravlja i bolesti]]></title_hr><title_en><![CDATA[Assessment of Daily Exposure to Metals and Maternal Individual Susceptibility as Factors of Developmental Origins of Health and Disease]]></title_en><user_id>128</user_id><user_firstLast_name>Jasna Jurasović</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2016-06</proposal_call><code>IP-2016-06-1998</code><acronim><![CDATA[METALORIGINS]]></acronim><duration>01.06.2017 - 31.03.2022</duration><status>Završio</status><financ_value>132.722,81 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Javno zdravstvo i zdravstvena zaštita, Temeljne medicinske znanosti, Kliničke medicinske znanosti, </scie_field_hr><scie_field_en>Public health and health services, Basic Medical Sciences, Clinical sciences, </scie_field_en><institution_hr><![CDATA[Institut za medicinska istraživanja i medicinu rada]]></institution_hr><institution_en><![CDATA[Institute for Medical Research and Occupational Health]]></institution_en><team_members_id>3934, 12585, 216, 3046, 341, 830, 4161, 4156, 12850, 2649, 215, 12504, 198, 4799, 640, 24445, 233, </team_members_id><team_members_names><![CDATA[Daria Pašalić, Sandra  Stasenko, Tatjana Orct, Karmen Branović Čakanić, Alica Pizent, Maja Lazarus, Irena Brčić Karačonji, Nataša Brajenović, Anja Mikolić, Blanka Tariba Lovaković, Ankica Sekovanić, Antonija Sulimanec Grgec, Zorana Kljaković-Gašpić, Jelena Kovačić, Lana Škrgatić, Iva Miškulin, Martina Piasek, ]]></team_members_names><keywords_hr><![CDATA[toksični esencijalni metal/polumetal, interakcija elemenata, pušenje cigareta, reproduktivno razdoblje žene, prenatalni razvoj, epigenetički biljezi]]></keywords_hr><keywords_en><![CDATA[toxic and essential metals/metalloids, element interaction, cigarette smoking, women’s reproductive period, prenatal development, epigenetic markers]]></keywords_en><summary_hr><![CDATA[Nepovoljni događaji tijekom prenatalnoga razvoja, majčine deficijencije nutrijenata, izloženost toksičnim metalima i pušenje cigareta, mogu izravno remetiti fetalni razvoj, ali i utjecati na postnatalno zdravlje tijekom života povećavajući rizik za brojne bolesti odrasle dobi. Projektom će se procjenjivati povoljni učinci i opasnosti u uvjetima neizbježne svakodnevne izloženosti i unosa esencijalnih i glavnih toksičnih metala/polumetala u ranjivoj skupini žena tijekom trudnoće, koji uz majčinu osobnu (negenetičku i genetičku) osjetljivost mogu utjecati na fetalnu epigenetičku regulaciju in utero i tako biti čimbenici razvojnoga podrijetla zdravlja i bolesti (koncept developmental origins of health and disease, DOAHD). Izloženosti hranom i pušenjem cigareta (samoodređenjem i pušenje određivanjem kotinina u urinu majke) te rizici za zadravlje procjenjivat će se presječnimm epidemiološkim istraživanjem metodoma humanoga biološkog monitoringa u 150 parova rodilja-dijete nakon ročnog rodničkog porođaja u rodilištu (povrh prije skupljenih sličnih podataka i bioloških uzoraka u >200 ispitanica). Biološki biljezi izloženosti/unosa bit će razine toksičnih (Cd, Pb, Hg i As) i esencijalnih (Ca, Fe, Zn, Cu i Se) metala/polumetala u majčinoj krvi/serumu i urinu, krvi/serumu pupkovine i posteljičnom tkivu. Biljezi učinaka bit će aktivnost antioksidacijskih enzima (SOD i GPx) te razine metalotioneina (MT) i posteljičnih steroidnih hormona (P4 i E2). Procijenit će se povezanosti razina metala/polumetala i MT s genskim polimorfizmima MT2A majki. Postnatalni zdravstveni rizici zbog promjena razvojnoga programiranja procijenit će se epigenetičkim markerima, metilacijom DNA i razinama ekspresije mikro RNA. Rabit će se osjetljive i sofisticirane metode i oprema za pripreme i analize uzoraka ljudskoga podrijetla. Jedinstveni doprinos u biomedicinskim istraživanjima bit će dobivanje inovativnih podataka u toksikogenomici – okolišnoj epigenetici metala, prvi te vrste u Hrvatskoj.]]></summary_hr><summary_en><![CDATA[Prenatal insults, such as maternal nutrient deficiencies, toxic metals’ exposure and cigarette smoking may disrupt fetal growth not only directly, but may also have impact on postnatal health across the life course increasing a risk for various diseases in adulthood. The project will assess health benefits and risks of unavoidable, daily environmental exposure and intake of nutritionally essential and main toxic metals/metalloids in a vulnerable population group of women during child-bearing period that, along with maternal individual (non-genetic and genetic) susceptibility, may alter intrauterine fetal epigenetic regulation and thus may be factors of developmental origins of health and disease (paradigm DOAHD). The exposures via food and tobacco smoking (based on self-reporting and smoking quantified by maternal urine cotinine) and health risks will be assessed in a cross-sectional epidemiological study using methods of human biological monitoring in 150 postpartum women-infant pairs after term vaginal deliveries in a maternity hospital (in addition to previously collected data and similar samples in >200 participants). Biomarkers of exposure/intake will be toxic (Cd, Pb, Hg, As) and essential (Ca, Fe, Zn, Cu, Se) metal/metalloid levels in maternal blood/serum and urine, umbilical cord blood/serum and placental tissue. Biomarkers of effects will be antioxidant enzymes (SOD, GPx), metallothionein (MT), and placental steroid hormones (P4, E2). Associations of maternal metal/metalloid and MT levels with MT2A genetic polymorphisms will be assessed. Potential postnatal health risks due to developmental programming changes will be evaluated by epigenetic markers, DNA methylation and microRNA expression levels. Sensitive and sophisticated methods and equipment for human sample preparations and analyses will be used. Unique contribution in biomedical research will be providing novel data in toxicogenomics–environmental epigenetics of metals, first of that kind in Croatia.]]></summary_en></project><project>
<id>4387</id><title_hr><![CDATA[Energetski neovisna Hrvatska bazirana na visokom udjelu obnovljivih izvora energije te različitih tehnologija brzog odziva]]></title_hr><title_en><![CDATA[Energy independent Croatia based on high penetration of Renewable Energy Sources and demand response technologies]]></title_en><user_id>13012</user_id><user_firstLast_name>Neven Duić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>PKP</proposal_type><proposal_call>2016-06</proposal_call><code>PKP-2016-06-3300</code><acronim><![CDATA[RESFlex]]></acronim><duration>01.04.2017 - 31.03.2019</duration><status>Završio</status><financ_value>178.392,73 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Strojarstvo, Elektrotehnika, Računarstvo, Tehnologija prometa i transport, </scie_field_hr><scie_field_en>Mechnical engineering, Electrical engineering, Computer sciences, Transport technology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet strojarstva i brodogradnje]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Mechanical Engineering and Naval Architecture]]></institution_en><team_members_id>13036, 13333, 6990, 20485, 13053, 20505, 20525, 19762, 22649, 12978, 22565, 25095, </team_members_id><team_members_names><![CDATA[Tomislav Pukšec, Goran Krajačić, Zeljko Tomšić, Henrik Lund, Tomislav Novosel, Natasa Markovska, Michael  Narodoslawsky, Marko Ban, Borna Doračić, Boris Ćosić, Nikola Matak, Hrvoje  Dorotić, ]]></team_members_names><keywords_hr><![CDATA[Niskougljični razvoj, Dugoročno energetsko planiranje, integracija OiE, tehnologije brzog odziva, elektrifikacija transportnog sektora, satni modul po]]></keywords_hr><keywords_en><![CDATA[Low carbon development, long term energy planning, RES integration, demand response technologies, electrification of the transport sector, hourly dema]]></keywords_en><summary_hr><![CDATA[Cjelovita energetska politika EU sastavljena je od niza pojedinačnih strategija integriranih u cjeloviti energetsko klimatski paket. Kao rezultat te cjelovite politike nameće se postupna tranzicija ka niskougljičnom razvoju i društvu. U energetskom smislu, ključne će biti strategije integracije obnovljivih izvora energije (OiE) na EU razini te dugoročna kroz-sektorska politika energetske učinkovitosti.  Republika Hrvatska, kao punopravna članica EU, dužna je osigurati tehnički i cjenovno optimalnu tranziciju, imajući u vidu maksimalnu korist za čitavo društvo; energetsku, gospodarsku te ekološku. Niz tehnologija koje iskorištavaju OiE su danas tehnički i ekonomski u potpunosti konkurentne te smo došli u situaciju u kojoj su potrebne nove sheme integracije; kako tehničke tako i financijske. S financijske strane je potrebna razrada novih mehanizama integracije obnovljivih tehnologija, temeljenih na mrežnom paritetu, te satnim tržištima energije. S tehničke strane potrebna je razrada inovativnih mehanizama fleksibilizacije, prije svega elektroenergetskog sustava, gdje dolazi do promjene paradigme u kojoj prelazimo sa sustava u kojem proizvodnja prati potrošnju na sustav u kojem potrošnja prati varijabilnu proizvodnju. Kao temelji ove nove paradigme javljaju se tehnologije koje omogućuju kroz-sektorsku integraciju OiE, kao što su power2heat/cool tehnologije (spremanje viškova električne energije kroz toplinske spremnike i centralizirane toplinske/rashladne sustave temeljene na inovativnim tržišnim mehanizmima), različiti oblici skladištenja energije, elektrifikacija transporta, fleksibilizacija potrošnje i sl. Predmet ovog istraživanja je integracija prethodno navedenih problema kroz napredan open access modelski okvir koji će zaživjeti kroz interaktivnu Internet platformu. Koncept pametnog energetskog sustava biti će razvijan pristupom odozdo prema gore, kako bi se omogućila modularnost sustava, uključujući lokalni/regionalni/nacionalni aspekt modeliranja]]></summary_hr><summary_en><![CDATA[EU energy policy as a whole is made out of a number of different strategies that are integrated into a climate & energy package. This policy results in gradual transition towards low-carbon development and society. In terms of energy, strategies for implementation and integration of renewable energy sources, on EU level will be the key, as well as long-term cross-sector energy efficiency policy. Croatia, as a full member of EU, is obliged to ensure technically and economically optimal transition in terms of energy, economy and ecology, to provide maximal benefit for the society as a whole. A number of different technologies that are utilising renewable energy sources are now completely technically and economically competitive. Because of that, new integration schemes are necessary, both from technical and financial perspective. From financial perspective, new mechanisms for integration of renewable technologies need to be developed, based on grid parity and hourly energy markets. From technical perspective, innovative mechanisms for flexibilisation of power system need to be developed. This leads to a transition from current system, where supply follows demand, to a new system, where demand follows supply. The basis for this new paradigm are new technologies that enable cross-sector integration of intermittent energy sources, like power2heat/power2cool technologies (storing excess electricity by the means of heat storage and district heating and cooling systems, which are based on innovative market mechanisms), different energy storage technologies, transport electrification, flexibilisation of consumption, etc. The subject of this research is integration of abovementioned problems through an advanced open access model framework, which will function as an interactive online internet platform. Smart energy system concept will be developed with bottom up approach, since this enables modularity of the system, including local/regional/national modelling aspect. ]]></summary_en></project><project>
<id>4388</id><title_hr><![CDATA[Glikozilacija alfa kiselog glikoproteina - put prema personaliziranoj terapiji]]></title_hr><title_en><![CDATA[Glycosylation of alpha-1- acid glycoprotein - route to personally oriented medicine]]></title_en><user_id>12360</user_id><user_firstLast_name>Mario Gabričević</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2016-06</proposal_call><code>IP-2016-06-3672</code><acronim><![CDATA[GlycoDrugs]]></acronim><duration>20.03.2017 - 19.02.2022</duration><status>Prekinut</status><financ_value>129.139,29 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Farmacija, Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Pharmaceutical sciences, Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Farmaceutsko-biokemijski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Pharmacy and Biochemistry]]></institution_en><team_members_id>4009, 1075, 13603, 25302, 26516, </team_members_id><team_members_names><![CDATA[Tin Weitner, Ognjen Čulić, Erim Bešić, Robert Kerep, Tino Šeba, ]]></team_members_names><keywords_hr><![CDATA[alfa kiseli glikoprotein, glikozilacija, konstanta vezanja lijeka, personalna terapija, lijekovi ]]></keywords_hr><keywords_en><![CDATA[alpha acid glycoprotein, glycosylation, drug binding constant, personally oriented therapy, drugs ]]></keywords_en><summary_hr><![CDATA[Nakon što se lijek aplicira u krv, on se najčešće u određenoj mjeri vezuje na proteine plazme. Važnost ovakvog vezanja je dobro opisana u literaturi, a udio vezanja pri ravnotežnim uvjetima određuje koncentraciju slobodnog lijeka. Slobodni udio lijeka je najčešće onaj koji je raspoloživ za aktivnost ili difuziju u okolna tkiva te se stoga samo nevezana frakcija lijeka smatra aktivnim oblikom, u skladu s “principom slobodnog lijeka”. Kao posljedica visoke koncentracije, proteini plazme kontroliraju koncentraciju slobodnog lijeka u plazmi, kao i u biološkim odjeljcima koji su s njom u ravnoteži, utječući na taj način na djelotvornost in vivo. U kliničkom smislu ovaj kapacitet treba se uzeti u obzir kad se određuje doza lijeka ili procjenjuje moguća toksičnost primijenjenog lijeka, što je obično dodatno usloženo uslijed promijena u kapacitetu proteina za vezanje lijeka kod određenih pacijenata. Izrazito glikozilirani alfa kiseli glikoprotein je jedan od dva proteina koji vežu veliki broj različitih lijekova i općenito utječu na djelotvornost lijekova. Postoje tri genetičke varijante i to F1, S i A. Vezanje lijekova za AGP može biti promijenjeno i u brojnim patološkim i fiziološkim stanjima kao rezultat promjene u glikozilacijskom uzorku. Ukupno gledano, tri faktora utječu na vezanje lijekova za AGP: Koncentracija AGP-a, omjer različitih genetičkih varijanti i promjene u glikozilacijskom uzorku. Ciljevi projekta su: 1. Kako različite genetičke varijante AGP-a utječu na ukupno vezanje lijekova? 2. Kakav je utjecaj promijenjenog glikozilacijskog uzorka na vezanje lijekova 3.  Predviđenje slobodnog udijela lijeka ovisno o navedena tri faktora. Koristit će se fizikalne metode kao fluorescencijska spektroskopija, ravnotežna dijaliza i masena spektroskopija kako bi se odredio utjecaj glikozilacijskih promjena AGP-a na vezanje lijekova i posljedično predvidio utjecaj te promjene na terapiju.]]></summary_hr><summary_en><![CDATA[After the administration of the drug to the blood stream, it often binds to a certain extent to plasma proteins. The importance of such plasma protein binding is a well recognized phenomenon and the extent of this association at equilibrium determines the concentration of unbound drug. Free fraction of the drug is most commonly the only one available for active uptake or diffusion into the surrounding tissue according to the “free drug principle”. Due to their high concentration, the plasma proteins control the free drug concentration in plasma thus influencing the drug potency in vivo. Clinically, this effect should be considered when adjusting the dosage of a drug, as well as in assessing the toxicity of the administered drug which is often complicated by changes in patient’s protein-binding capacity. Heavily glycosylated alpha-1-acid glycoprotein (AGP) is one of two proteins present in sufficient quantity to bind a broad variety of drugs and generally has a significant effect on drug action. Adding to complexity, human AGP exists as a heterogeneous population of three genetic variants namely F1, S and A. Importantly, drug binding to the AGP may be altered in numerous pathological and physiological states as a result of changes in glycosylation pattern. Overall, there are three major factors influencing binding of drugs to AGP: Concentration of AGP, ratio of different genetic forms and changes in glycosylation. Goals of this project are: 1. How different genetic forms of native AGP influence the overall drug binding? 2. What is the influence of changed glycosylation patterns of AGP on drug binding? 3. “Free drug” prediction dependent on mentioned three factors. We will use physical methods like fluorescence spectroscopy, equilibrium dialysis and MS to evaluate influence of AGP glycosylation change on drug binding and subsequently predict influence on drug therapy.]]></summary_en></project><project>
<id>4406</id><title_hr><![CDATA[Aminoacil-tRNA-sintetaze kao čuvari standardnog genetičkog koda]]></title_hr><title_en><![CDATA[Aminoacyl-tRNA synthetases as gatekeepers of the standard genetic code]]></title_en><user_id>7711</user_id><user_firstLast_name>Ita Gruić Sovulj</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2016-06</proposal_call><code>IP-2016-06-6272</code><acronim><![CDATA[AARSCODE]]></acronim><duration>01.03.2017 - 31.08.2021</duration><status>Završio</status><financ_value>132.722,81 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, Biologija, </scie_field_hr><scie_field_en>Chemistry, Biology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>19864, 20026, 19876, 19945, 20081, 20056, 20017, 24303, 24302, 27538, </team_members_id><team_members_names><![CDATA[Marko Močibob, Morana Dulić, Mario Kekez, Maja Barači, Jasmina Rokov Plavec, Nediljko Budiša, Gregor Anderluh, Marija Viher, Igor Živković, Valentina Ević, ]]></team_members_names><keywords_hr><![CDATA[aminoacil-tRNA-sintetaze, biosinteza proteina, kontrolni mehanizmi u translaciji, norvalin, sintetske aminokiseline, editing]]></keywords_hr><keywords_en><![CDATA[aminoacyl-tRNA synthetases, protein biosynthesis, translational quality control, norvaline, synthetic amino acids, editing]]></keywords_en><summary_hr><![CDATA[Genetički kod definira zakonitosti koje omogućavaju prevođenje genetičke informacije u funkcionalne molekule proteina. Suodnos kodona i aminokiseline ostvaruje se pomoću aminoacil-tRNA-sintetaza (aaRS), enzima koji sparuju aminokiselinu s pripadnom molekulom tRNA. Visok stupanj točnosti u translaciji osigurava se dijelom kroz korektivne mehanizme enzima aaRS. Učestalost mistranslacije predstavlja važno pitanje u temeljnim istraživanjima i njihovoj primjeni u medicini i biotehnologiji. Korektivni mehanizmi također djeluju kao čuvari standardnog genetičkog koda i sprječavaju ugradnju prirodnih aminokiselina koje nisu definirane genetičkim kodom. Ti mehanizmi, s druge strane, mogu otežati ugradnju sintetskih aminokiselina u dizajnerske proteine.U sklopu projekta predlaže se istraživanje sintetskih i korektivnih mehanizama enzima koji omogućuju ugradnju leucina, valina i izoleucina u proteine. Usporedit ćemo katalitičke principe i specifičnost sintetskog i korektivnog mjesta tih enzima prema proteinogenim aminokiselinama i onima koje nisu kodirane genetičkim kodom. Također, istražit ćemo toksičnost mistranslacije i stanični odgovor na izazvani stres. Cilj je razumjeti principe koji definiraju odabir standardne aminokiselinske abecede te kako narušavanje genetičkog koda utječe na staničnu fiziologiju. Navedene spoznaje olakšat će usmjerenu ugradnju fluoriranih aminokiselina u dizajnerske proteine. Konačno, testirat ćemo postojanje sprege između točnosti translacije i adaptacije na stres izazvan okolišnim uvjetima.Ovo istraživanje, kroz redizajniranje suodnosa kodona i aminokiseline, nalazi se na granici biokemije i kemijske biologije. Atraktivnost i izvedivost predloženog istraživanja uočljiva je kroz suradnje naše grupe, značajno prepoznate u polju biosinteze proteina, s istaknutim internacionalnim (Prof. Budiša, TU Berlin, Prof. Anderluh, NIC, Ljubljana, Prof. Maček, Proteome Center Tübingen) i domaćim (Dr. Vianello, IRB, Zagreb) partnerima. ]]></summary_hr><summary_en><![CDATA[The genetic code provides the basis for translation of genetic information into functional proteins. Codon assignments are established by aminoacyl-tRNA synthetases (aaRS), which couple amino acids to their cognate tRNAs. Mistakes in translation are generally kept low, in part by inherent aaRS hydrolytic editing. The extent to which mistranslation occurs presents a fundamental question in basic research with impact on medicine and biotechnology. AaRS quality control mechanisms also act as gatekeepers of the standard genetic code and prevent infiltration of natural but non-coded amino acids. Consequently, they present an obstacle for synthetic amino acid translation in rational protein design.Here we propose to investigate the synthetic and editing mechanisms of three aaRSs responsible for translation of amino acids that build the protein core: leucine, valine and isoleucine. We will compare the catalytic principles and gained specificity of the enzymes’ synthetic and editing sites against proteinogenic and non-coded amino acids. The cellular toxicity and stress responses of induced non-canonical mistranslation will be addressed. The goal is to improve our understanding of the basis for selection of the natural amino acid alphabet, and how violation of the coding principles influences cell physiology. Mechanistic insight will extend our ability to apply fluorinated amino acids in protein rational design. A possible link between altered translational fidelity and adaptation to environmental stress will be sought. This research couples biochemistry and chemical biology through the interest in reassignment of the genetic code. The assembled expertise through the international (Prof. Budiša, TU Berlin, Prof. Anderluh, NIC, Ljubljana, and Prof. Maček, Proteome Center Tübingen) and national (Dr. Vianello, RBI, Zagreb) collaborators will strongly enhance the capacity of our group, which is well-recognized in the field of protein translation, to conduct this research.]]></summary_en></project><project>
<id>4414</id><title_hr><![CDATA[Kooperativna robotika u nadzoru i istraživanju mora]]></title_hr><title_en><![CDATA[Cooperative robotics in marine monitoring and exploration]]></title_en><user_id>5962</user_id><user_firstLast_name>Nikola Mišković</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2016-06</proposal_call><code>IP-2016-06-2082</code><acronim><![CDATA[CroMarX]]></acronim><duration>01.04.2017 - 31.12.2021</duration><status>Završio</status><financ_value>132.258,28 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Elektrotehnika, Temeljne tehničke znanosti, </scie_field_hr><scie_field_en>Electrical engineering, Basic engineering sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id>19968, 18903, 6426, 19973, 19989, 20001, 19979, 17737, 21329, </team_members_id><team_members_names><![CDATA[Anja Babić, Zoran Vukić, Antonio Vasilijević, Ivan Lončar, Zdravko Eškinja, Đula Nađ Nađ, Marin Stipanov, Filip Mandić, Nadir Kapetanović, ]]></team_members_names><keywords_hr><![CDATA[robotika, kooperativna robotika, pomorska robotika, autonomna površinska plovila, autonomna ronilica, višerobotski sustavi]]></keywords_hr><keywords_en><![CDATA[robotics, cooperative robotics, marine robotics, autonomous surface marine vehicles, autonomous underwater vehicle, multi-robot systems]]></keywords_en><summary_hr><![CDATA[Bespilotna plovila (površinska i podvodna) se uspješno koriste za nadzor i istraživanje mora. Ona igraju veliku ulogu u mnogim područjima primjena kao što su morska biologija, morska ekologija, podvodna arheologija, akvakultura, pomorska sigurnost, offshore industrija. Sve pomorske zemlje, kao i Hrvatska koja ima jurisdikciju nad skoro polovicom Jadranskog mora, imaju obavezu nadgledati, istraživati i štititi svoja morska dobra.CroMarX projekt unosi novu dimenziju u nadzor i istraživanje mora uvođenjem kooperativnih plovila koja povećavaju operativnu učinkovitost. Glavni cilj CroMarX projekta je istražiti i razviti kooperativne upravljačke algoritme  u području pomorske robotike, uzimajući u obzir bespilotna površinska plovila (USV, engl. Unmanned Surface marine Vehicles) i bespilotne ronilice (UUV, engl. Unmanned Underwater Vehicles) u svrhu nadzora i istraživanja mora. Prvo, razvit ćemo kooperativne strategije za upravljanje flotom USV-ova kako bi se povećale sposobnosti distribuiranog nadzora mora. Drugo, razvit ćemo upravljačke algoritme koji omogućuju kooperaciju između USV-a i UUV-a, što će značajno povećati istraživačke sposobnosti UUV-ova kroz unaprjeđenje navigacijskih mogućnosti. Treće, razvit ćemo sustav za upravljanje misijama koji će osigurati pregled stanja plovila i imati ulogu korisniku prihvatljivog centra za upravljanje i zadavanje misija pojedinačnom plovilu kao i floti plovila. Na kraju, razvijeni algoritmi će biti eksperimentalno potvrđeni u sklopu tri definirana scenarija: 1) kooperativno upravljanje flotom USV-ova, 2) upravljanje flotom USV-ova koje se adaptira utjecajima iz okoliša, i 3) kooperativno upravljanje između USV-a i UUV-a.]]></summary_hr><summary_en><![CDATA[Unmanned marine vehicles (surface and underwater) are successfully exploited for monitoring and exploring the marine environment. They play a large role in many application fields such as marine biology, marine ecology, underwater archaeology, aquaculture, marine security, offshore industry. All maritime countries, as well as Croatia with jurisdiction over almost half of the Adriatic Sea, have the obligation to monitor, explore and protect their marine environment.CroMarX project brings a new dimension to marine monitoring and exploration by introducing cooperative marine vehicles that increase operational efficiency. The main objective of the CroMarX project is to investigate and develop cooperative control algorithms in the area of marine robotics, taking into account both unmanned surface marine vehicles (USVs) and an unmanned underwater vehicle (UUV) for the purpose of marine monitoring and exploration. Firstly, we will develop cooperative control strategies for operating a fleet of USVs in order to increase capabilities of distributed marine monitoring operations. Secondly, we will develop control algorithms that allow cooperation between a USV and a UUV, which will significantly enhance exploratory abilities of UUVs by increasing their navigational capabilities. Thirdly, we will develop a mission controller that will ensure situational awareness and act as a user-friendly command and control centre for commanding missions to individual vehicles as well as fleets of vehicles. Finally, the developed algorithms will be experimentally validated within three defined scenarios: 1) cooperative control of a fleet of USVs, 2) environmentally adaptive control of a fleet of USVs, and 3) cooperative control between a USV and a UUV. ]]></summary_en></project><project>
<id>4425</id><title_hr><![CDATA[ET TIBI DABO: naručitelji i donatori umjetnina u Istri, Hrvatskom primorju i sjevernoj Dalmaciji od 1300. do 1800. godine]]></title_hr><title_en><![CDATA[ET TIBI DABO: Commissions and Donors in Istria, Croatian Littoral and North Dalmatia from 1300 to 1800]]></title_en><user_id>269</user_id><user_firstLast_name>Nina Kudiš</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2016-06</proposal_call><code>IP-2016-06-1265</code><acronim><![CDATA[donart]]></acronim><duration>20.03.2017 - 19.09.2021</duration><status>Završio</status><financ_value>73.304,83 eur</financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Povijest umjetnosti, Povijest, Arheologija, </scie_field_hr><scie_field_en>Art history, History, Archeology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Filozofski fakultet u Rijeci]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Humanities and Social Sciences]]></institution_en><team_members_id>839, 700, 845, 847, 1088, 2946, 1009, 20021, 20064, 20071, 20138, 3253, 25243, 27385, </team_members_id><team_members_names><![CDATA[Marijan Bradanović, Laris Borić, Damir Tulić, Mateja Jerman, Danijel Ciković, Ivan Braut, Iva Jazbec Tomaić, Ana Šitina, Petar Puhmajer, Krasanka Majer Jurišić, Josip Višnjić, Željko Bistrović, Mario Pintarić, Marin Bolić, ]]></team_members_names><keywords_hr><![CDATA[donatori, naručitelji, društv. elite, Istra, Hr. primorje, sjev. Dalmacija, arhitektura, skulptura, slikarstvo, primijenjena umjetnost, 1300. – 1800. ]]></keywords_hr><keywords_en><![CDATA[donors, commissions, social elites, Istria, Croatian Littoral, North Dalmatia, architecture, sculpture, painting, applied arts, 1300 - 1800]]></keywords_en><summary_hr><![CDATA[Cilj projekta je istražiti utjecaj društvenih elita i pojedinaca na širenje umjetničkih oblika, stilova i rješenja. Taj su proces na području Hrvatske što je u žarištu ovog istraživanja, dijelom kreirali i najvažniji predstavnici europskih dvorova, poput habsburških careva, bavarskih vojvoda, venecijanskih duždeva, apostolskih nuncija i kardinala. Uvid u razloge i odlike njihovih narudžbi omogućit će bolje razumijevanje položaja i htijenja lokalnih donatora u europskom kontekstu. Primjenom metode istraživanja pojedinačnih slučajeva, pokušat će se doći do zaključaka, primjenjivih ne samo na područje jadranske Hrvatske, već i na teritorij Mletačke republike, Apeninskog poluotoka i Srednje Europe. U radu na projektu će uz voditeljicu sudjelovati još 12 istraživača, od kojih je 6 iskusnih znanstvenika s brojnim radovima objavljenim u Hrvatskoj i inozemstvu, a čak 6 mlađih istraživača su studenti doktorskih studija. Glavnina rada na projektu sastojat će se od istraživanja na terenu te usavršavanja u hrvatskim i inozemnim bibliotekama i arhivima. Rezultati istraživanja na projektu, čiji se dodir s interdisciplinarnošću ogleda u povezivanju povijesno-umjetničkog i historiografskog istraživanja, kao i istraživanja socijalnih fenomena, bit će od koristi istraživanjima u heraldici, genealogiji, sfragistici, etnologiji, povijesti književnosti, glazbe i mode te povijesti društva i kulture. U okviru projekta organizirat će se dvije znanstvene radionice i dva međunarodna znan. skupa na kojima će uz istraživače na projektu sudjelovati i drugi znanstvenici iz Hrvatske i inozemstva. Sva četiri skupa rezultirat će zbornicima radova opremljenima znanstvenom aparaturom te objavljenima na internetskoj stranici projekta. Jedan od važnih ciljeva projekta je i diseminacija rezultata istraživanja koja će se provoditi kroz javna predavanja istraživača, prisustvo u medijima, ali naročito kroz kraće diseminacijske tekstove koje će istraživači sustavno objavljivati na blog stranici projekta. ]]></summary_hr><summary_en><![CDATA[The project intends to investigate the influence of the social elites and individuals on the propagation of artistic forms, styles and solutions. In the Croatian territory that will be in the focus of this project, such a process was significantly shaped by the most important representatives of the European courts, such as Habsburg emperors, Bavarian Dukes, Venetian doges, Apostolic Nuncios and Cardinals. A better insight into reasons and characteristics of their commissions will generate a better understanding of the situation and aspirations of the local donors in the European context. By applying the “case study” methodology, we will try to reach conclusions, valid not only for the complete Croatian littoral, but also for the territory of the Venetian Republic, the Apennine Peninsula and Central Europe. Apart from the principal investigator, 12 researchers will take part in the project, half of which are experienced scholars with numerous papers published in Croatia and abroad and half of them are concluding their PhD studies. The project will mainly consist in field research and training and research in the Croatian and international libraries and archives. The results of the research, that interconnects art history and historiography, as well as the research of social phenomena, should also prove valuable for the research in heraldry, genealogy, sphragistics, ethnology, history of literature, music, fashion, as well as the cultural history. The project will also comprise two workshops for the participants and two international conferences, all resulting in proceedings that will be published online. One of the most important goals of the project is the dissemination of the research results through its web page and blog (numerous shorter articles by all the researchers), public lectures and the media.]]></summary_en></project><project>
<id>4428</id><title_hr><![CDATA[Razvoj integriranog mikrosustava za biokatalitičku proizvodnju biodizela]]></title_hr><title_en><![CDATA[Development of integrated micro-system based biocatalytic process for biodiesel production]]></title_en><user_id>7049</user_id><user_firstLast_name>Bruno Zelić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2016-06</proposal_call><code>IP-2016-06-7993</code><acronim><![CDATA[DeMSy(BioPro)2]]></acronim><duration>01.05.2017 - 30.04.2021</duration><status>Završio</status><financ_value>99.628,38 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Kemijsko inženjerstvo, Temeljne tehničke znanosti, </scie_field_hr><scie_field_en>Chemical engineering, Basic engineering sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet kemijskog inženjerstva i tehnologije]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Chemical Engineering and Technology]]></institution_en><team_members_id>428, 6308, 4070, 309, 4717, 4306, 6012, 9886, 25366, 25444, 25659, </team_members_id><team_members_names><![CDATA[Anita Šalić, Ana Jurinjak Tušek, Ana  Bucić-Kojić, Marina Tišma, Mirela Planinić, Sandra Budžaki, Davor Valinger, Dinko Sinčić, Martin Gojun, Marta Ostojčić, Darijo Šibalić, ]]></team_members_names><keywords_hr><![CDATA[biodizel, enzim lipaza, pročišćavanje, mikroreaktor, integrirani proces]]></keywords_hr><keywords_en><![CDATA[biodiesel, lipase, purification, microreactor, integrated process]]></keywords_en><summary_hr><![CDATA[U današnje vrijeme kada se raspoloživost i dostupnost fosilnih goriva značajno smanjuje, potreba za proizvodnjom biogoriva iz različitih obnovljivih izvora je sve izraženija. Biorazgradivost, netoksičnost i mala emisija štetnih tvari samo su neka od svojstava koja čine biodizel ekološki prihvatljivijim gorivom. Cilj ovog projekta je razviti integrirani mikrosustav za biokatalitičku proizvodnju biodizela. U tu svrhu će se proizvesti biokatalizator, enzim lipaza podrijetlom iz gljive Thermomyces lanuginosus fermentacijom na čvrstom otpadu prehrambene industrije kao supstrat, sintetizirati biodizel transesterifikacijom u kotlastom bioreaktoru i različitim mikroreaktoriskim sustavima korištenjem komercijalno dostupne i lipaze proizvedene fermentacijom na čvrstim nosačima pomoću gljive T. lanuginosus, provesti separaciju glicerola u prvoj fazi i pročišćavanje dobivenog biodizela u drugoj fazi primjenom membranske ultrafiltracije na modulima sa šupljim vlaknima kako bi proizvedeni biodizel kvantitativno i kvalitativno zadovoljio propisane norme. Kao supstrat u procesu transeterifikacije koristit će se svježe i otpadno jestivo ulje, a rezultati pokusa provedenih u različitim reaktorskim konfiguracijama će se usporediti kako bi se izabrao najpogodniji reakcijski sustav. Po prvi puta razvit će se integrirani mikroreaktorski sustav koji će na jednom čipu omogućiti kontinuiranu proizvodnju biodizela dok će se na drugom čipu odvijati kontinuirana separacija i pročišćavanje biodizela korištenjem filtera integriranih u sustav. Osim provedbe pokusa posebna pozornost će se posvetiti i razvoju matematičkog modela procesa proizvodnje biodizela u mikroreaktoru. Razvit će se 2D i 3D matematički model procesa, a rezultati simulacije matematičkog modela procesa koristit će se u svrhu boljeg razumijevanja strujanja reakcijske smjese u mikrokanalu, optimizacije procesa i uvećanja procesa.]]></summary_hr><summary_en><![CDATA[Nowadays as the availability and accessibility of fossil fuels is significantly declining, the need for the production of biofuels from various renewable sources is becoming increasingly interesting. Biodegradability, non-toxicity and low pollution emissions are merely some properties making biodiesel a more environmentally friendly fuel. The aim of this project is to develop an integrated microsystem for the biocatalytic production of biodiesel. For this purpose: (i) an enzyme lipase from the fungus Thermomyces lanuginosus will be produced on solid waste from food industry, (ii) biodiesel will be produced using transesterification reaction in a stirred-tank bioreactor and different microrector systems utilising a commercially available lipase and a lipase produced by solid-state fermentation using the fungus T. lanuginosus, (iii) separation of glycerol will be carried out in the first phase and purification of the obtained biodiesel in the second phase applying  the membrane ultrafiltration modules with hollow fibres to produce biodiesel that quantitatively and qualitatively fulfils the prescribed standards. Fresh and waste cooking oil will be used as a substrate in the transesterification process. The results of the experiments conducted in different reactor configurations will be compared in order to select the most appropriate reaction system. For the first time, an integrated microreactor system will be developed. The continuous production of biodiesel will take place in a single chip, while another chip will be used for continuous separation and purification of biodiesel using a filter integrated into the system. Special attention will be paid to the development of mathematical models for biodiesel production in a microreactor. 2D and 3D mathematical models will be developed for the processes and the results of mathematical model simulations will be used to better understand the flow of the reaction mixture, process optimization and process scale up.]]></summary_en></project><project>
<id>4430</id><title_hr><![CDATA[Sintetička magnetska polja uz međudjelovanja i anyoni]]></title_hr><title_en><![CDATA[Synthetic magnetic fields with interactions and anyons]]></title_en><user_id>5776</user_id><user_firstLast_name>Hrvoje Buljan</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2016-06</proposal_call><code>IP-2016-06-5885</code><acronim><![CDATA[SynthMagIA]]></acronim><duration>15.03.2017 - 14.03.2021</duration><status>Završio</status><financ_value>110.522,66 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, </scie_field_hr><scie_field_en>Physics, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>19416, 19411, 4493, 856026, 4045, </team_members_id><team_members_names><![CDATA[Dario Jukić, Tena Dubcek Dubcek, Karlo Lelas, Marija  Todorić, Bruno Klajn, ]]></team_members_names><keywords_hr><![CDATA[međudjelujući bozonski plin, sinetetičko magnetsko polje, anyoni, nelinearnost, fotoničke rešetke]]></keywords_hr><keywords_en><![CDATA[interacting Bose gases, synthetic magnetic fields, anyons, nonlinearity, photonic lattices]]></keywords_en><summary_hr><![CDATA[U ovom projektu istražujemo međudjelujuće ultrahladne atomske plinove u sintetičkim magnetskim (baždarnim) poljima (SMGF od eng. Synthetic Magnetic/Gauge Field), moguće eksperimentalne realizacije anyona (čestica s necjelobrojnom statistikom koja interpolira između statistike za bozone i fermione), te analogne fotoničke sustave. Naš tim ima višegodišnje iskustvo istraživanja međudjelujućih ultrahladnih atomskih plinova i fotoničkih sustava, što se izvrsno uklapa u tematiku projekta. Čuveno necjelobrojno kvantno Hallovo (FQH) stanje pojavljuje se u sustavu međudjelujućih nabijenih čestica u jakom magnetskom polju, zatočenim u dvije dimenzije (2D). Anyoni su dosad eksperimentalno realizirani kao kvazičestice višečestičnih pobuđenja samo u tom sustavu. Bogatstvo FQH stanja motivira potragu za novim (topološkim) stanjima tvari u međudjelujućim bozonskim sustavima. Ultrahladni atomski plinovi idealan su poligon za kontroliranu pripremu, manipulaciju i detekciju kvantnih višečestičnih stanja. Kako bi ostvarili topološka stanja (analogna FQH stanju) u ultrahladnim plinovima, potrebno je stvoriti SMGF u kojem će se (neutralni) atomi ponašati kao elektroni u magnetskom polju. Većina radova o SMGF dosad bila je fokusirana na jednočestične efekte, što nas motivira za ovo istraživanje. Znanstveni dio projekta organiziran je u tri radna paketa (WP od eng. Work Package). U WP1 istražujemo SMGF u međudjelujućim bozonskim sustavima, za sve raspone međudjelovanja i dimenzionalnosti (1D-3D). Ciljevi su (i) otkrivanje i istraživanje novih topoloških faza i stanja, te (ii) istraživanje granica samih metoda, sugerirajući poboljšanja i nove sheme. U WP2, anyoni u ultrahladnim atomskim plinovima, ciljevi su (i) istražiti i predložiti moguće eksperimentalne realizacije anyona koristeći ultrahladne plinove, te (ii) predložiti i proučiti potpise anyona u tim sustavima (npr. simulirajući time-of-flight eksperimente u 2D). U WP3 ćemo povezati naš rad sa SMGF u fotoničkim sustavima. ]]></summary_hr><summary_en><![CDATA[In this project we explore interacting ultracold atomic gases in synthetic magnetic (gauge) fields (SMGF), explore potential experimental realizations and signatures of anyons (particles with fractional statistics interpolating between bosons and fermions), and analogous photonic systems. Our team has expertise and experience of research in interacting ultracold atomic gases as well as in optics and photonics; thus, the design of the project is perfectly suited for our team. The famous fractional quantum Hall (FQH) state emerges in a system of interacting charged particles in a strong magnetic field, confined in two-dimensions (2D). The richness of FQH state motivates the quest for novel topological states of matter in interacting bosonic systems. Ultracold atomic gases are ideal playground for a controlled preparation, manipulation, and detection of quantum many-body states. To achieve topological states (such as the FQH state) in ultracold atomic gases, one must create a SMGF wherein (neutral) atoms behave as electrons in a magnetic field. Most of the work on SMGF up-to-date was focused on single particle effects, which provides great motivation for this project. The scientific effort is systematically organized in three workpackages (WP). In WP1, synthetic gauge/magnetic fields in interacting bosonic systems, all interaction ranges and dimensionalities (1D-3D) are explored. The objectives are to (i) discovering and exploring novel topological phases and states and (ii) to explore the boundaries and limitations of methods, suggesting improvements and novel schemes. In WP2, anyons in ultracold atomic gases, the objectives are (i) to explore and propose potential experimental realization of anyons using ultracold gases, and (ii) to propose and investigate the signatures of anions in these systems (e.g., by simulating time-of-flight experiments in 2D). In WP3, we connect our work to synthetic magnetic fields in photonics.]]></summary_en></project><project>
<id>4437</id><title_hr><![CDATA[Politika vremena u post-jugoslavenskoj prozi: Zamišljanje temporalnosti književnih kultura transnacionalnosti ]]></title_hr><title_en><![CDATA[The Politics of Time in the post-Yugoslav Prose: Imagining Temporalities of Literary Cultures of Transnationality]]></title_en><user_id>6591</user_id><user_firstLast_name>Aleksandar Mijatović</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2016-06</proposal_call><code>IP-2016-06-9548</code><acronim><![CDATA[POLITI]]></acronim><duration>06.03.2017 - 05.05.2019</duration><status>Završio</status><financ_value>38.821,42 eur</financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Filologija, Filozofija, Povijest, </scie_field_hr><scie_field_en>Philology, Philosophy, History, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Filozofski fakultet u Rijeci]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Humanities and Social Sciences]]></institution_en><team_members_id>3737, 19173, 1368, 19690, 12357, 1335, </team_members_id><team_members_names><![CDATA[Danijela Marot Kiš, Dejan Durić, Saša Stanić, Eva Simčić, Miranda Levanat-Peričić, Marina Biti, ]]></team_members_names><keywords_hr><![CDATA[pripovijedanje, vrijeme, subjekt, transnacionalnost, tekst, kultura, pamćenje]]></keywords_hr><keywords_en><![CDATA[narration, time, subject, transnationality, text, culture, memory]]></keywords_en><summary_hr><![CDATA[Predloženi će se projekt fokusirati na konstrukciju fikcionalnog i povijesnog vremena u post-jugoslavenskoj prozi. Formiranje temporalnosti povezat će se s literarnim, estetskim, kulturalnim i geopolitičkim konstrukcijama Balkana i post-jugoslavenskoga stanja. Umjesto naziva ‘hrvatska’, ‘bosanska’ ili ‘srpska’ književnost koristit će se naziv ‘post-jugoslavenska’ književnost. Pod nazivom ‘post-jugoslavenski’ podrazumijevat će se iskustvo fragmentacije ranije prihvaćenoga zajedničkog društvenog, kulturalnog i etničkog prostora, neprevodivost kulturalnog, socijalnog i političkog iskustva novonastalih nacionalnih država te iskustvo egzila pisaca koji su, privremeno ili trajno, napustili svoje domovine. Predlaganjem termina ‘post-jugoslavenski’ kao zamjene za nacionalne etikete ukazuje se na vremensko iskustvo transnacionalnosti post-jugoslavenske literature. Politika vremena implicitno prisutna u post-jugoslavenskoj prozi bit će polazišna točka istraživanja. Dosadašnja su se istraživanja fokusirala na tematiku egzila, melankolije, prostora, identiteta (rodnoga, etničkoga, klasnoga) i proizvodne kulture u djelima post-jugoslavenskih pisaca. U većini istraživanja problemi vremena i moderniteta te njihove relacije spram transnacionalne imaginacije u post-jugoslavenskoj prozi bili su tek podrazumijevani, no nikad i eksplicitno istraženi kao važna teorijska tema. Cilj predloženoga projekta je eksplicirati politiku vremena i ulogu vremena u konstituiranju transnacionalnosti u djelima post-jugoslavenskih pisaca. Temporalna konstrukcija transnacionalnoga subjekta i zajednice središnja je tema predloženoga projekta i polazišna točka promišljanja prethodnih istraživanja.]]></summary_hr><summary_en><![CDATA[The proposed project will be focused on the construction of fictional and historical time in the post-Yugoslav prose. The construction of temporality will be related to the literary, aesthetic, cultural and geopolitical construction of the Balkan and post-Yugoslav conditions. With the notion of ‘post-Yugoslav’ it will be referred to the experience of fragmentation of previously common civic, cultural and ethnic space, to the intranslatability of cultural, social and political experience between newly emerged nation-states, exiled life of writers who left (permanently or temporarily) their homelands. By proposing usage of the term ‘post-Yugoslav’, instead of national labels, it will be elaborated the temporal experience of transnationality of post-Yugoslav literature.The politics of time implicitly developed in the post-Yugoslav prose will be taken as a starting point. Scholarship has so far focused on topics of exile, melancholia, space, identity (gender, ethnic, class) and commodity culture in the works of post-Yugoslav writers. However, the problems of time, modernity and their relation to the transnational imagination in the post-Yugoslav prose was only implied in the most of these accounts, and has not been explicated so far as a salient theoretical topic. The aim of the proposed project is to explicate the politics of time and its role in the constitution of transnationality in the works of post-Yugoslav writers. Temporal constitution of transnational subject and community is the central topic of the proposed project and it will be starting point for rethinking the previous research. ]]></summary_en></project><project>
<id>4438</id><title_hr><![CDATA[Patogeneza citomegalovirusne infekcije u jajnicima, utjecaj na plodnost i održavanje trudnoće]]></title_hr><title_en><![CDATA[Pathogenesis of cytomegalovirus infection in the ovaries, impact on fertility and pregnancy maintenance]]></title_en><user_id>4682</user_id><user_firstLast_name>Vanda Juranić Lisnić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2016-06</proposal_call><code>IP-2016-06-5980</code><acronim><![CDATA[JaPI]]></acronim><duration>01.06.2017 - 31.05.2021</duration><status>Završio</status><financ_value>132.722,81 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Medicine]]></institution_en><team_members_id>19694, 19695, 5357, 23779, 28629, </team_members_id><team_members_names><![CDATA[Jelena Tomac, Mijo Golemac, Daria Kveštak, Marija Mazor, Ana Vrbanović Vrbanović, ]]></team_members_names><keywords_hr><![CDATA[citomegalovirus, plodnost, jajnici, trudnoća, progesteron, infekcija, patogeneza, pobačaj]]></keywords_hr><keywords_en><![CDATA[cytomegalovirus, fertility, ovaries, pregnancy, progesterone, infection, pathogenesis, pregnancy-loss]]></keywords_en><summary_hr><![CDATA[Humani citomegalovirus (HCMV) je herpes virus kojim je zaražena većina svjetske populacije. Infekcija HCMV-om opasna je u trudnica: može izazvati pobačaj ili brojne trajne malformacije ploda. Efikasno cjepivo ne postoji, a dostupni lijekovi imaju brojne nuspojave. Infekcija miševa mišjim CMV-om najčešće je korišteni model kojim se istražuje biologija i patogeneza HCMV-a. U našem dosadašnjem radu primijetili smo da MCMV vrlo uspješno inficira jajnike spolno zrelih ženki miševa. Detaljnijom analizom ustanovili smo da je infekcija ograničena na žuta tijela i stromu jajnika. Folikuli, strukture u kojima se čuva jajna stanica do trenutka ovulacije, nisu bili inficirani. Čak i kod infekcije imunosuprimiranog mišjeg soja IFNgamma KO koji slabo kontrolira virus, folikuli su većinom ostali neinficirani unatoč izuzetno snažnoj infekciji žutih tijela i strome. Infekcija žutih tijela može ugroziti trudnoću, a infekcija folikula ugrožava cjelokupni fertilitet jedinke te je razumijevanje mehanizama kojima se folikuli brane od infekcije od izuzetne važnosti. Naša preliminarna istraživanja pokazuju da se folikularne stanice mogu inficirati ex vivo; stoga predlažemo istraživanja kojima bi se utvrdili morfološki i imunološki faktori koji brane folikule od infekcija u jajniku. Razumijevanje mehanizama kojima se folikuli brane od infekcije prirodnim patogenom pomoći će nam u rasvjetljavanju nekih uzroka neplodnosti.Žuta tijela glavni su proizvođači hormona progesterona koji je neophodan za održavanje trudnoće, posebno rane. Naša preliminarna istraživanja pokazuju da infekcija jajnika MCMV-om značajno smanjuje razinu progesterona te bi tako mogla dovesti do pobačaja. Stoga ćemo istražiti mehanizme koji dovode do smanjenja razina progesterona  kao i potencijalni terapeutski učinak davanja progesterona zaraženim trudnim ženkama.Zaključno, predloženo istraživanje predstavlja važan korak ka razumijevanju utjecaja infekcije izuzetno učestalim patogenom na reproduktivno zdravlje.]]></summary_hr><summary_en><![CDATA[Human cytomegalovirus (HCMV) is a herpes virus that infects the majority of world’s population. Infection during pregnancy can lead to pregnancy-loss or numerous developmental disabilities of the fetus. There is no effective vaccine while available treatments have numerous side-effects.Murine CMV infection of mice is the most commonly used model to study the biology and pathogenesis of HCMV. We observed strong infection of the ovaries of sexually mature female mice, in stroma and corpora lutea. Interestingly, the infection was excluded from the ovarian follicles, structures that contain oocytes. Even when very immunosuppressed mouse strain IFNgamma KO was infected, follicles mostly remained uninfected despite nearly complete infection of corpora lutea and stroma. Infection of corpora lutea may endanger ongoing pregnancy while infection of follicles threatens whole reproductive capacity. Therefore, better understanding of mechanisms that protect follicles from naturally occurring infections is of utmost importance. Since our preliminary results show that follicular cells can be infected ex vivo, we propose to investigate morphological and immunological factors that protect the follicles. Understanding the mechanisms that protect the follicles during infection with a natural and pervasive pathogen may help in uncovering etiology of infertility. Corpora lutea are the main producers of progesterone, hormone essential for pregnancy maintenance, especially early. Our preliminary data shows that MCMV infection of ovaries results in significant downregulation of serum progesterone levels which could cause abortions. We therefore wish to investigate the mechanisms behind this downregulation and therapeutic application of exogenous progesterone treatment.In conclusion, the proposed research is an important step in understanding the impact of naturally occurring pervasive pathogen on reproductive health.]]></summary_en></project><project>
<id>4444</id><title_hr><![CDATA[Multimodalni prikaz molekularnih zbivanja tijekom oporavka mišjeg mozga nakon ishemijskog oštećenja]]></title_hr><title_en><![CDATA[Multimodal molecular imaging of the mouse brain repair after ishemic lesion]]></title_en><user_id>7297</user_id><user_firstLast_name>Srećko Gajović</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2016-06</proposal_call><code>IP-2016-06-1892</code><acronim><![CDATA[RepairStroke]]></acronim><duration>01.12.2017 - 30.11.2021</duration><status>Završio</status><financ_value>132.722,81 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb School of Medicine]]></institution_en><team_members_id>12709, 19958, 20098, 7637, 19937, 19920, 6226, 25254, 27600, 861751, </team_members_id><team_members_names><![CDATA[Siniša Škokić, Kristina Šemanjski, Krešimir Sanković, Ivan Bohaček, Ana Hrkać Pustahija, Anton Glasnović, Marina Dobrivojević, Paula Josić, Sanja Srakočić, Rok Ister, ]]></team_members_names><keywords_hr><![CDATA[moždani udar, miš, snimanje magnetskom rezonancijom, snimanje bioluminiscencijom, upala]]></keywords_hr><keywords_en><![CDATA[stroke, mouse, magnetic resonanse imaging, bioluminescence imaging, inflammation]]></keywords_en><summary_hr><![CDATA[Moždani udar predstavlja vodeći zdravstveni problem, te postoji potreba razumijevanja mehanizma oporavka i mogućeg liječenja mozga nakon moždanog udara. Ovim projektom pokušava se razjasniti slijed zbivanja tijekom oporavka mozga primjenom multimodalnog prikaza molekularnih zbivanja u mozgu živog miša. To će se postići primjenom niza modaliteta snimanja živih miševa magnetskom rezonancijom, te pretkliničkim optičkim snimanjem bioluminiscencije. Eksperimentalnim zatvaranjem srednje moždane arterije postići će se ishemijsko oštećenje mišjeg mozga. Procesi koji će biti promatrani uključuju upalu (praćenu bioluminiscencijom Tlr2-luc transgeničnog miša), stvaranje novih nastavaka živčanih stanica (praćenu bioluminiscencijom Gap43-luc transgeničnog miša), apoptozu (praćenu zatočenim DEVD-luciferinom), poremećaj i obnovu povezanosti mozga (difuzijskim tenzornim snimanjem magnetskom rezonancijom), te obnovu perfuzije mozga (označavanjem spina u arterijama tijekom snimanja magnetskom rezonancijom) , čijom kombinacijom se očekuje uočiti kritična molekularna i stanična zbivanja koja djeluju neuroprotektivno i obnavljaju mozak. Snimanja živog miša korelirat će se s funkcionalnim i morfološkim analizama mišjeg mozga mikroskopijom i testovima ponašanja životinja. Ovim će se omogućiti definiranje parametara oporavka mozga u mišjem modelu moždanog udara kako bi se pretklinički provjerili mogući terapijski pristupi i omogućila njihova translacija u kliničke pokuse.]]></summary_hr><summary_en><![CDATA[Stroke is the leading health problem, hence a need to understand the mechanism of recovery and possible treatment of the brain dammaged by stroke. This project attempts to clarify the sequence of events during the brain recovery after ischemic lesion by using in vivo multimodal molecular imaging of the mouse brain. This will be achieved through a combination of imaging modalities including magnetic resonance imaging (MRI), and preclinical optical bioluminescence imaging (BLI). Mouse stroke model of the middle cerebral artery occlusion (MCAO) will result in the ischemic brain damage. The processes that will be monitored include inflammation (visualized by bioluminescence of TLR2-luc transgenic mouse), extension of neuronal processes (visualized by bioluminescence of GAP43-luc transgenic mouse), apoptosis (followed by caged DEVD-luciferin), brain connectivity (MR diffusion tensor imaging), and brain perfusion (MRI arterial spin labeling), which combination is expected to describe critical molecular and cellular events that act neuroprotective and regenerate brain. In vivo imaging will be correlated with functional and morphological analysis of the mouse brain using microscopy and behavioral tests. This will allow to define the preclinical parameters of recovery of the brain in a mouse model of stroke to be used to evaluate possible therapeutic approaches and enable their translation into the clinical trials.]]></summary_en></project><project>
<id>4452</id><title_hr><![CDATA[Racionalnost: između logičkog ideala i svakodnevnog zaključivanja ]]></title_hr><title_en><![CDATA[Rationality: between Logically Ideal and Commonsensical in Everyday Reasoning]]></title_en><user_id>3843</user_id><user_firstLast_name>Majda Trobok</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2016-06</proposal_call><code>IP-2016-06-2408</code><acronim><![CDATA[RACIO]]></acronim><duration>15.03.2017 - 14.07.2020</duration><status>Završio</status><financ_value>59.458,84 eur</financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Filozofija, </scie_field_hr><scie_field_en>Philosophy, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Filozofski fakultet u Rijeci]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Humanities and Social Sciences]]></institution_en><team_members_id>6429, 4612, 7371, 6529, 19802, 6074, 23262, </team_members_id><team_members_names><![CDATA[Davor Lauc, Igor Bajšanski, Danilo Šuster, Olga Markič, Paolo Labinaz, Martina Blečić, David Grčki, ]]></team_members_names><keywords_hr><![CDATA[racionalnost, logika, zaključivanje, prirodni jezik, argumentacija, kritičko mišljenje]]></keywords_hr><keywords_en><![CDATA[rationality, logic, reasoning, natural language, argumentation, critical thinking]]></keywords_en><summary_hr><![CDATA[Opći je cilj projekta odrediti narav i značajke racionalnosti shvaćene kao kriterij ispravnog zaključivanja. Područje istraživanja čini prostor između jakog normativnog standarda racionalnosti određenog formalnim logičkim pravilima i istraživanja koja nastoje izvesti norme zaključivanja na temelju stvarnog ponašanja ljudi pri rješavanju deduktivnih zadataka. Fokus istraživanja oslanja se na logicistički pristup racionalnosti koji će biti podvrgnut provjeri s obzirom na ponašanje subjekata prilikom svakodnevnog zaključivanja.Kako bi se ostvario taj cilj istraživačke su aktivnosti usmjerene na istraživanja vezana uz četiri teme:1) Prirodni jezik kao medij za deduktivno zaključivanje. Ako su logička pravila barem djelomično normativna za ispravno zaključivanje, važan je podcilj istražiti mogućnosti izražavanja i zrcaljenja logičkih operatora u prirodnome jeziku.2) Uloga individualnih razlika u svakodnevnom zaključivanju. Istaknuta je značajka svakodnevnoga zaključivanja da subjekt zahvaća deduktivni problem u skladu s onim kako ga razumije, stoga je moguća aktivacija različitih mehanizama zaključivanja. Prihvatljivost ove hipoteze značajno će utjecati na raspravu o postojanju jedinstvenog standarda racionalnosti.3) Racionalnost u kontekstu društvenih interakcija, posebno u argumentacijskom procesu. Argumentacijski je proces bitno određen oblikovanjem i procjenjivanjem argumenata, što od sudionika zahtijeva dijeljenje istih komunikacijskih i deduktivnih pravila.4) Pitanje kritičkoga mišljenja određuje područje istraživanja u kojem će sva ranije spomenuta pitanja biti sažeta, analizirana i testirana u kontekstu različitih područja svakodnevnoga života te će dobiveni rezultati poslužiti za formuliranje regulativnih uputa za moguće unaprjeđenje vještina kritičkoga mišljenja.Najznačajnijim se doprinosom projekta može smatrati pokušaj određenja dobro usklađenog standarda racionalnosti smještenog između ideala logičkih pravila i prakse svakodnevnoga zaključivanja.]]></summary_hr><summary_en><![CDATA[The overall goal of the project is to determine the nature and characteristics of rationality understood as a criterion of correct reasoning. The research area is the space between a strong normative standard of rationality determined by formal logical rules and researches that strive to derive norms of reasoning from the actual people’s behavior in solving deductive tasks. The focal point of the investigation relies on the logistic approach to rationality to be tested against subjects’ behavior in everyday reasoning.To reach this goal, research activities will be focused on investigations in four topics:1) Natural language as a media for deductive reasoning. If logical rules are at least partly normative for correct reasoning, the important sub-goal is to investigate natural language’s possibilities to express and mirror logical terms.2) The role of individual differences in everyday reasoning. The salient feature of everyday reasoning is that the subject responds to a deductive problem as he/she understands it, so the activation of a variety of reasoning mechanisms is possible. If this hypothesis can be confirmed, it will significantly contribute to the debate concerning uniqueness or plurality of the rationality standard(s). 3) The rationality of social interactions, particularly in the argumentative process. The argumentative process is determined by the making and assessing of arguments, which requires a mutual recognition of communicative and deductive rules. 4) The issue of critical thinking determines the investigation area in which all mentioned questions could be summarized, analyzed and tested in various fields of everyday life and the obtained results will be used to enable the articulation of prescriptions for a possible improvement of critical thinking skills. The most important contribution of the project can be seen as an attempt to determine the well-balanced standard of rationality placed between ideal logical rules and everyday reasoning practice.]]></summary_en></project><project>
<id>4454</id><title_hr><![CDATA[Precizni izračuni fizikalnih veličina u supersimetričnim modelima fizike čestica]]></title_hr><title_en><![CDATA[Precise computations of physical quantites in supersymmetric particle physics models]]></title_en><user_id>3140</user_id><user_firstLast_name>Amon Ilakovac</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2016-06</proposal_call><code>IP-2016-06-7460</code><acronim><![CDATA[PRECIOUS]]></acronim><duration>31.03.2017 - 31.08.2021</duration><status>Završio</status><financ_value>106.510,05 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, </scie_field_hr><scie_field_en>Physics, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>19722, 20093, 856160, </team_members_id><team_members_names><![CDATA[Marija Mađor-Božinović, Dominik Stoeckinger, Hermes Bélusca, ]]></team_members_names><keywords_hr><![CDATA[supersimetrija, algebarska renormalizacija, masa Higgsovog bozona, precizne opservable, nesačuvanje leptonskog broja]]></keywords_hr><keywords_en><![CDATA[supersymmetry, algebraic renormalization, Higgs boson mass, precision observables, lepton flavour violation]]></keywords_en><summary_hr><![CDATA[Najnoviji LHC eksperimenti dali su dva važna nova rezultata. Prvi je izmjerena masa Higgsovog bozona s preciznošću od 0.2 % s time da se u drugoj izvedbi LHC eksperimenta na 13 GeV očekuje dodatno poboljšanje na 0.1 %. Time je masa Higgovog bozona uvrštena u precizne opservable. Drugi rezultat je da nije opažena fizika izvan standardnog modela (SM) ostavljajući podatke o neutrinskim oscilacijama kao jedini akceleratorski dokaz fizike izvan standardnog modela. Time nije osigurano rješenje problema hijerarhije u standardnom modelu. Kao što je dobro poznato rješenje problema hijerarhije u SM poznato je u supersimetričnim teorijama i u jako spregnutim teorijama. Ideja ovog projekta je da razmotri na novi način precizne opservable sa posebnom pozornošću na izračun mase Higgsovog vozona u supersimetričnim modelima (SSM) koji dozvoljavaju neutrinske oscilacije. Zbog najavljenih poboljšanja eksperimentalne osjetljivosti leptonskih dipolnih momenata i opservabli vezanih uz procese s nabijenim leptonima koji narušavaju leptonski okus, proučavat ćemo modele koji dopuštaju ne-zanemarive doprinose spomenutim opservablama kao i druge opservable okusa potisnute u SM. Kako bi se postigli ti ciljevi, istraživanje će se provoditi u dva smjera.  Jedan smjer se odnosi na poboljšanje sadašnjih metoda određivanja parametara mekog narušenja SUSY u  modelima   mekanog narušenja SUSY na visokoj skali. Drugi smjer istraživanja ima za cilj poboljšanje izračuna amaplituda općeg SSM na nivou dviju petlji (i više). Ta poboljšanja primijenit će se na izračun renormalizacijskih grupnih jednadžbi preciznih opservabli i opservabli koje su potisnute ili zabranjene u SM. Rezultati dobiveni za eksperimentalno zanimljive opservable poslužit će da ograniče parametre razmatranih modela.]]></summary_hr><summary_en><![CDATA[The newest LHC experiments gave two important new results. First is the measurement of the Higgs boson mass with precision 0.2 % with a good prospect to be improved to 0.1% via the second run of LHC at 13 GeV enlisting the Higgs boson mass into the precision observables. The second is that no sign of physics beyond standard model has been found, leaving the neutrino oscillations data as only accelerator proof of the physics beyond the standard model, offering no solution for the standard model (SM) hierarchy problem. As is well known the solutions of the hierarchy problem of the standard model are known in supersymmetric theories and strongly coupled theories. The idea of this project is to reconsider the electroweak precision observables with special attention to the precise evaluation of the Higgs boson mass within the supersymmetric models (SSMs) permitting neutrino oscillations. Due to the forthcoming improvements of sensitivities of the lepton dipole moments and the charged lepton flavour violating (LFV) observables the models permitting non-negligible contribution to lepton flavour observables and SM model suppressed flavour observables will be considered. To achieve these goals two pathways will be followed. One is improvement of the present methods for determination of the soft SUSY breaking  parameters in the models with high scale soft SUSY breaking. The other is improvement of evaluation of the amplitudes for general SSMs at two loop (or beyond). These improvements will be applied to evaluation of renormalization group equations, precision observables and SM suppressed and forbidden observables. The results for the experimentally interesting observables will be used to constrain the model parameters.    ]]></summary_en></project><project>
<id>4457</id><title_hr><![CDATA[DNA barkodiranje bioraznolikosti hrvatske faune ]]></title_hr><title_en><![CDATA[DNA barcoding of Croatian faunal biodiversity]]></title_en><user_id>19707</user_id><user_firstLast_name>Mladen Kučinić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2016-06</proposal_call><code>IP-2016-06-9988</code><acronim><![CDATA[CroBarFauna]]></acronim><duration>01.03.2017 - 31.12.2021</duration><status>Završio</status><financ_value>130.639,06 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Biologija, </scie_field_hr><scie_field_en>Biology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>4269, 12386, 12919, 3003, 19798, 129, 19965, 19167, 19840, 19064, 20104, 19618, 19724, 19871, 20101, 19972, 19144, 19063, 28678, 27433, 27422, 27437, 27427, </team_members_id><team_members_names><![CDATA[Martina Podnar Lešić, Jasna Lajtner, Lucija Šerić Jelaska, Branka Bruvo Mađarić, Irena Grbac, Stjepan Krčmar, Darko Cerjanec, Vlatka Mičetić Stanković, Ivan Vučković, Martina Šašić Kljajo, Ignac Sivec, Nikola Tvrtković, Nediljko Landeka, Roman Ozimec, Ana Mrnjavčić Vojvoda, Mauro Štifanić, Anđela Ćukušić, Iva Mihoci, Dora Hlebec, Nataša Graovac, Edin Lugić, Neven Iveša, Moira Buršić, ]]></team_members_names><keywords_hr><![CDATA[DNA barkodiranje, određivanje vrsta, bioraznolikost, kriptične vrste, zaštita]]></keywords_hr><keywords_en><![CDATA[DNA barcoding, species identification, biodiversity, cryptic species, protection]]></keywords_en><summary_hr><![CDATA[Metoda DNA barkodiranja predložena je 2003. godine kao univerzalni sistem za determinaciju biološkog materijala u smislu identifikacije vrste, a također i kao metoda za otkrivanje novih, još neopisanih vrsta koje se ne mogu međusobno razlikovati na temelju morfoloških obilježja (tzv. kriptičnih vrsta). Temelji se na određivanju slijeda nukleotida standardiziranog fragmenta mitohondrijskog gena za podjedinicu I citokrom oksidaze (COI) duljine oko 650 pb.Geografskim smještajem na zapadnom Balkanu i Mediteranu, teritorij Hrvatske predstavlja jednu od europskih „žarišnih točaka biološke raznolikosti“ (biodiversity hotspot). Visoki stupanj bioraznolikosti Hrvatske posljedica je raznolikog sastava staništa, klimatskih i hidroloških značajki kao i kompleksne geološke povijesti regije.Glavni cilj ovog istraživačkog projekta je upotrebom metode DNA barkodiranja steći uvid u opseg i geografsko rasprostranjenje ukupne genetske bioraznolikosti ciljanih skupina faune Hrvatske, te prepoznati vrste koje je neophodno dodatno detaljno istražiti s taksonomskog, filogenetskog i filogeografskog aspekta.U okviru ovog projekta prioritet će biti dan taksonomskim skupinama za koje postoje taksonomski stručnjaci među projektnim suradnicima s već djelomično prikupljenim materijalom, a s druge strane skupine koje su taksonomski potencijalno vrlo zanimljive i za koje je DNA barkodiranje već započeto u okviru ostalih Europskih inicijativa za barkodiranje.Podaci o DNA barkodovima prikupljeni ovim istraživanjem omogućiti će točniju identifikaciju velikog broja vrsta te ukazati na potrebu dodatnih istraživanja pojedinih skupina. Ukazati će vjerojatno i na nove, nepoznate kriptičke, možda i endemske vrste u Hrvatskoj, što bi imalo veliki značaj za razvitak strategija i planova za zaštitu bioraznolikosti u Hrvatskoj. Osim toga rezultati će imati moguću primjenu i u biomonitoringu kao i u epidemiološkim studijama (npr. kontrola štetnika, identifikacija i praćenje prijenosnika bolesti).]]></summary_hr><summary_en><![CDATA[DNA barcoding was proposed in 2003. as a universal system for assignment of specimens to a particular species but also as a tool for recognition of yet undescribed morphologically indistinguishable cryptic species. The method is based on the sequencing of standardized, ~650 bp long fragment of the mitochondrial cytochrome c oxidase subunit 1 gene (COI).Geographically located in the Western Balkan and Mediterranean basin, Croatian territory has great habitat diversity and represents one of the European biodiversity hotspots. High biodiversity index is consequence of very diverse habitats, climatic and hydrological features as well as complex geological history of the region. The primary goal of the proposed research project is to investigate the amount and geographic distribution of the genetic biodiversity of selected groups of Croatian fauna by using DNA barcoding methodology, flagging species for further rigorous taxonomic, phylogenetic and phylogeographic studies.In the frame of the proposed project the priority will be given to potentially taxonomically especially interesting groups, that have taxonomic expert among project collaborators, certain amount of already collected material, and groups for which DNA barcoding is already in progress within other European barcode initiatives.DNA barcodes obtained in this research will enable simple, fast and accurate identification for a great number of species, and flag certain groups for further investigation. They would most probably provide insights in some of still unrecognized or overlooked, cryptic, probably endemic species in Croatia. The assessment will be of primary importance for the development of strategies and action plans for the conservation of biodiversity in Croatia. In addition, these results will also find application in biomonitoring as well as for epidemiological studies (identification and monitoring of disease vectors).]]></summary_en></project><project>
<id>4459</id><title_hr><![CDATA[Mogućnosti reindustrijalizacije hrvatskog gospodarstva]]></title_hr><title_en><![CDATA[Possibilities for reindustrialization of Croatian economy]]></title_en><user_id>4139</user_id><user_firstLast_name>Nebojša Stojčić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2016-06</proposal_call><code>IP-2016-06-3764</code><acronim><![CDATA[REINDUCE]]></acronim><duration>01.01.2017 - 31.12.2019</duration><status>Završio</status><financ_value>39.737,21 eur</financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Ekonomija, </scie_field_hr><scie_field_en>Economy, </scie_field_en><institution_hr><![CDATA[Sveučilište u Dubrovniku]]></institution_hr><institution_en><![CDATA[University of Dubrovnik]]></institution_en><team_members_id>5973, 20159, 189, 20133, 5713, 20280, 25381, </team_members_id><team_members_names><![CDATA[Perica Vojinić, Katarina  Bačić, Ivan-Damir   Anić, Tonći Svilokos, Zoran  Aralica, Meri Šuman Tolić, Slavo Radosevic, ]]></team_members_names><keywords_hr><![CDATA[reindustrijalizacija, inovacije, poduzetništvo, FDI, međunarodna trgovina, institucije]]></keywords_hr><keywords_en><![CDATA[reindustrialization, inovations, entrepreneurship, FDI, international trade, institutions]]></keywords_en><summary_hr><![CDATA[Pretpostavka projekta REINDUCE je da završetak ekonomske integracije Hrvatske u EU zahtijeva značajnu konvergenciju produktivnosti i zaposlenosti prema prosjeku zemalja EU. Koncept kojega podržava REINDUCE je nova industrijska politika, prilagođena hrvatskim specifičnostima i aktualnostima. Tijekom proteklih dvadeset godina Hrvatska je prošla značajnu deindustrijalizaciju i u ovome trenutku mora pronaći svoj specifičan model reindustrijalizacije koji uzima u obzir vlastita povijesna i kulturna obilježja. Ti se izazovi analiziraju kroz sljedeća ključna područja: izvore, opseg i posljedice deindustrijalizacije, institucionalne promjene, inovacije, poduzetništvo i razvoj malih i srednjih poduzeća; međunarodnu trgovinu, izravna strana ulaganja i globalne lance vrijednosti; promjene ekonomske politike i institucionalne reforme. REINDUCE projektom ostvarit će se znatan iskorak u razumijevanju mikroekonomske dinamike hrvatskoga gospodarstva, a razumijevanje te dinamike je od presudne važnosti za buduće izglede rasta unutar EU. To će pružiti bolje i dublje razumijevanje ne-tržišnih prepreka i tržišnih neuspjeha iz raznih gospodarskih perspektiva, koje su potrebne da se ponište učinici dosadašnje nepovoljne deindustrijalizacije s ciljem poticanja procesa sustizanja naprednih nacionalnih gospodarstava. Predmet analize REINDUCE predstavlja jedan od najvažnijih pokušaja razmatranja ekonomske politike u Hrvatskoj danas: razumijevanje od razloga trenutnog ekonomskog stanja i kao i razvoj analitičkih alata zasnovanih na dokazima za kreatore ekonomske politike kao i prelazak sa deindustrijalizacije ka reindustrijalizaciji i promicanje procesa dostizanja prelaskom ka ekonomskim aktivnostima s visokom dodanom vrijednošću i znanjem intenzivnim aktivnostima. Ishod ovog projekta bit će nova istraživanja kojima je svrha produbiti razmišljanja o ekonomskoj politici, kao i preporuke zasnovane na nalazima i na širokome rasponu povezanih politika i alata.]]></summary_hr><summary_en><![CDATA[The premise of REINDUCE project is that the completion of economic integration of Croatia in EU requires rapid convergence of productivity and employment levels towards the EU average. Therefore, the overall concept underpinning REINDUCE is the new industrial policy adapted to the specificities and realities of Croatia.  Over past twenty years Croatia faced massive deindustrialization and needs to find its own specific model of reindustrialization which takes into account its own historical and cultural characteristics. These challenges are analysed through the following key areas: sources, extent and implications of deindustrialization; institutional changes and corporate governance, innovation, entrepreneurship and SME development; international trade, foreign investment and global value chains; policy changes and institutional reforms. The project will make a substantial step forward in understanding the microeconomic dynamics of the Croatian economy whose understanding is of crucial importance for its future growth prospects within the EU. It will provide a better and deeper understanding of non-market obstacles and market failures from a variety of economic perspectives, which are required to reverse the severe deindustrialization and to boost the catching-up process. The subject matter of REINDUCE represents one of the most important policy considerations of Croatia today: the understanding of the reasons behind the current economic state and the developing evidence-based tools for policy-makers to reverse de-industrialisation to re-industrialisation and to boost catching-up process by shifting economic activities to high value-added, knowledge-based activities. The outcome of this project will be new research to deepen the thinking on economic policy together with evidence-based recommendations on a wide range of linked policies and tools. ]]></summary_en></project><project>
<id>4463</id><title_hr><![CDATA[Preparation of Porous Thin-film Materials for water Purification using Atomic Layer Deposition (ALD)]]></title_hr><title_en><![CDATA[Priprema poroznih tankoslojnih materijala za pročišćavanje vode koristeći tehniku Depozicije atomskih slojeva (ALD)]]></title_en><user_id>20047</user_id><user_firstLast_name>Gabriela Ambrožić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2016-06</proposal_call><code>IP-2016-06-3568</code><acronim><![CDATA[WATPUR]]></acronim><duration>10.04.2017 - 09.09.2021</duration><status>Završio</status><financ_value>129.734,62 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, Fizika, </scie_field_hr><scie_field_en>Chemistry, Physics, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Fakultet za fiziku]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Physics]]></institution_en><team_members_id>19797, 19539, 20255, 20190, 19892, 3948, 116, </team_members_id><team_members_names><![CDATA[Mato Knez, Ivana Jelovica Badovinac, Iva Šarić, Robert Peter, Ivna Kavre Piltaver, Karlo Wittine, Ivana Gobin, ]]></team_members_names><keywords_hr><![CDATA[Pročišćavanje vode, porozni tanki filmovi, Uređaj za depoziciju atomskih slojeva (ALD), &#39;&#39;klik&#39;&#39; kemija, fotokataliza]]></keywords_hr><keywords_en><![CDATA[Water purification, porous thin films, Atomic layer deposition (ALD), &#39;&#39;click&#39;&#39; chemistry, photocatalysis]]></keywords_en><summary_hr><![CDATA[Specifični cilj predloženog projekta je priprema novih fotoaktivnih keramičkih tankih filmova s kontroliranom debljinom i dobro definiranim poroznim strukturama s izrazitom primjenom za pročišćavanje vode od organskih i bioloških zagađivača.U projektu se istražuju novi pristupi u sintezi ovih materijala, koristeći tehniku Depozicije atomskih slojeva (Atomic layer deposition - ALD) u kombinaciji s visoko selektivnom „klik“ kemijom, koji će unaprijediti osnovna znanja i razviti inovacije u sintezi materijala za primjenu u pročišćavanju vode zelenim tehnologijama. Sintetski i post-sintetski procesi su osmišljeni za dobivanje materijala s naprednom funkcionalnošću koja će omogućiti: smanjenje troškova tehnologija pročišćavanja voda kroz primjenu solarne energije, selektivnu adsorpciju organskih i bioloških zagađivača, foto-induciranu desorpciju organskih zagađivala, foto-induciranu razgradnju organskih onečišćujućih tvari i učinkovitu regeneraciju te ponovno korištenje tankoslojnih materijala.Ovi novi keramički materijali se razlikuju od tradicionalnih materiala i procesa za pročišćavanje i dezinfekciju vode upravo zbog sintetskih postupaka koje ćemo primijeniti, a koji će omogućiti narastanje potpuno novog tipa višenamjenskih keramičkih filmova deponiranih na biorazgradivom tekstilu / pamuku i anorganskim makroporoznim podlogama. Spomenute karakteristike će proširiti potencijal keramičkih materijala u različitim smjerovima primjene: od dekontaminacije mora od naftnih izlijeva do sustava za pročišćavanje pitke vode.]]></summary_hr><summary_en><![CDATA[The specific objective of the proposed project is to prepare novel materials for purification of water from organic and biological contaminants, based on photoactive ceramic thin-films with controllable inorganic film thickness and well-defined porous structures. The project explores a new approach in synthesis of these materials using atomic layer deposition (ALD) technique in combination with highly selective “click” chemistry that will advance the fundamental knowledge and develop innovations in synthesis of materials for potential applications in green-technology water purification. The synthetic and post-synthetic processes are designed in such a way that the advanced functionalities of these materials are expected to reduce the cost of water purification treatment through the application of solar energy, selective adsorption of organic and biological pollutants, photo-induced desorption of organic pollutants, photo-induced degradation of organic pollutants and effective regeneration and re-use of thin-film materials. The novel ceramic materials will differ from the conventional water disinfection and purification materials and processes as the applied procedures will give access to an entirely new class of multifunctional ceramic films deposited on biodegradable textile/cotton and inorganic macroporous substrates. These features will extend the potential of ceramic materials in different application directions: from seawater decontamination upon oil spilling to potable water purification systems. ]]></summary_en></project><project>
<id>4470</id><title_hr><![CDATA[Utjecaj prehrambenih vlakana na bioraspoloživost polifenola istraživanjem adsorpcije i simuliranih probavnih procesa, in vitro]]></title_hr><title_en><![CDATA[The influence of dietary fiber on bioaccessibility of polyphenols by studying adsorption and simulated digestion processes, in vitro]]></title_en><user_id>7376</user_id><user_firstLast_name>Lidija Jakobek</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2016-06</proposal_call><code>IP-2016-06-6777</code><acronim><![CDATA[BIO-POLIFENOL]]></acronim><duration>01.03.2017 - 30.06.2021</duration><status>Završio</status><financ_value>72.011,41 eur</financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Prehrambena tehnologija, Nutricionizam, </scie_field_hr><scie_field_en>Food technology, Nutrition, </scie_field_en><institution_hr><![CDATA[Sveučilište Josipa Jurja Strossmayera u Osijeku, Prehrambeno-tehnološki fakultet]]></institution_hr><institution_en><![CDATA[Josip Juraj Strossmayer University of Osijek, Faculty of Food Technology]]></institution_en><team_members_id>19843, 7424, 4661, 19154, 19959, 25258, </team_members_id><team_members_names><![CDATA[Petra Krivak, Ivana Tomac, Šime Ukić, Martina Skendrović Babojelić, Andrew Barron Barron, Jozo Ištuk, ]]></team_members_names><keywords_hr><![CDATA[adsorpcija, bioraspoloživost, b-glukan, prehrambena vlakna, polifenoli, bioaktivnosti]]></keywords_hr><keywords_en><![CDATA[adsorption, bioaccessibility, b-glucan, dietary fiber, polyphenols, bioactivities]]></keywords_en><summary_hr><![CDATA[Ranijim istraživanjima pokazalo se da polifenolni spojevi imaju razne bioaktivnosti. Od antioksidacijskog djelovanja do modulacije enzima, djelovanja metabolita polifenola, interakcija s mikroflorom te interakcija s makromolekulama prisutnima u hrani. Sve ove bioaktivnosti mogu zajedno objasniti potencijalno pozitivan utjecaj polifenola na zdravlje. U zadnje vrijeme pažnja se posvećuje interakcijama s makromolekulama u hrani jer one mogu utjecati na bioraspoloživost polifenola. Bioraspoloživost se definira kao količina nutrijenata koji su raspoloživi za apsorpciju u probavnom traktu. Ukoliko polifenoli kroz interakcije s molekulama iz hrane bivaju “zarobljeni” (vezani) za molekule to može utjecati na raspoloživost za njihovu apsorpciju te na njihovo djelovanje u organizmu. Prehrambena vlakna imaju potencijal  vezanja polifenola te ih na taj način mogu zaštititi od razgradnje i prenijeti u donje dijelove probavnog trakta. To može utjecati na bioraspoloživost, ali imati i druge potencijalno pozitivne efekte – polifenoli mogu u izvornom obliku pokazati pozitivne bioaktivnosti u donjim dijelovima probavnog trakta. U ovom projektu cilj je istražiti bioraspoloživost polifenola kroz dva procesa. Prvi bi bio istraživanje procesa adsorpcije polifenola na prehrambenim vlaknima (b-glukan). U ovom dijelu istraživala bi se adsorpcija polifenolnih standarda na prehrambena vlakna (b-glukan) te utjecaj pH, temperature i vremena na adsorpciju. Preko adsorpcije bi se interpretirale interakcije koje se mogu dogoditi između polifenola i prehrambenih vlakana. Drugi proces koji bi se istraživao bio bi simulirani probavni proces, in vitro, u kojem bi se simulirali probavni procesi te istraživala količina polifenola (iz voća) u izvornom obliku nakon probave te utjecaj prehrambenih vlakana na ovaj proces. Rezultatima iz istraživanja adsorpcije i simuliranih probavnih procesa interpretirala bi se bioraspoloživost polifenola te utjecaj prehrambenih vlakana na bioraspoloživost.]]></summary_hr><summary_en><![CDATA[Previous studies have shown that the polyphenolic compounds have various bioactivities: from antioxidant activity to the modulation of enzymes, the action of polyphenol metabolites, interaction with the microflora, and interactions with macromolecules present in food. All of these bioactivities can together explain a potentially positive effect of polyphenols on health. Lately, attention is paid to interactions with macromolecules in food because they can affect the bioaccessibility of polyphenols. Bioaccessibility is defined as the amount of nutrients available for absorption in the gastrointestinal tract. If polyphenols through interaction with molecules from food are &#39;&#39;captured&#39;&#39; (linked) to molecules that can affect the availability for their absorption and their effects in the body. Dietary fibers have the potential to bind polyphenols. Polyphenols can thus be protected from degradation and transferred to the lower parts of intestinal tract. This may affect the bioaccessibility, or have other potentially positive effects - polyphenols may in their original form show positive bioactivities in the lower digestive tract. In this project, the goal is to explore the bioaccessibility of polyphenols through two processes. The first will be the study the adsorption of polyphenols onto dietary fiber (b-glucan), along with the impact of pH, temperature and time on this process. Through adsorption, the interactions that can occur between polyphenols and dietary fiber could be interpreted. Another process that will be studied is the simulated digestion process, in vitro, which would simulate the digestive processes, explore the amount of polyphenols (in fruit) in its original form upon digestion, and the effect of dietary fiber on this process. The results from the adsorption and simulated digestive processes would be used to interpret bioaccessibility of polyphenols and the impact of dietary fiber on bioaccessibility.]]></summary_en></project><project>
<id>4472</id><title_hr><![CDATA[Fizika teraskale na LHC-u i u svemiru]]></title_hr><title_en><![CDATA[Terascale Physics for the LHC and Cosmos]]></title_en><user_id>19131</user_id><user_firstLast_name>Oleg Antipin</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2016-06</proposal_call><code>IP-2016-06-4418</code><acronim><![CDATA[TsPhLC]]></acronim><duration>01.03.2017 - 31.05.2021</duration><status>Završio</status><financ_value>83.084,48 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, </scie_field_hr><scie_field_en>Physics, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>3243, 2665, 19929, 25341, 25595, </team_members_id><team_members_names><![CDATA[Ivica Picek, Blaženka Melić, Francesco Sannino, Jahmall Matteo Bersini, Alessio  Maiezza, ]]></team_members_names><keywords_hr><![CDATA[neutrinske mase, asimptotskih sigurnih teorija, LHC, Standardnog modela,kosmologija]]></keywords_hr><keywords_en><![CDATA[neutrino mass, asymptotically safe theories, LHC, Standard Model, cosmology]]></keywords_en><summary_hr><![CDATA[Europska zajednica je uložila mnogo u razvoj LHC (Velikog hadronskog sudarača čestica) da bi se rješili neki osnovni problemi u fizici visokih energija. LHC Run-2 period koji upravo počinje bi se mogao pokazati kao najuzbudljivije vrijeme u fizicičestica u 21. stoljeću jer postoje naznake za postojanje novih čestica iz ranijih podataka s LHC-a. Ovaj prijedlog projekta će doprinjeti rješavanju fundamentalnih problema unutar fizike visokih energija u svjetlu novih LHC podataka. Cilj ovog projektnog prijedloga je da se dotaknu problemi proširenjem Standardnog modela (SM) jakih, slabih i elektromagnetskih interakcija koje su trenutno prihvačeni teorijski okvir za opisivanje fundamentalnih interakcija elementarnih čestica.Glavni kriterij za uspjeh je dovoljno poznavanje novih eksperimentalnih podataka od strane jakog teorijskoj tima vodećih svjetskih znanstvenika koji rade na povezivanjuizmeđu računa na superračunalnim rešetkama, teorijskih metoda teorije polja, fizike izvan SM i kozmologije. Zajedno sa svojim timom, doprinjet ću različitim relevantnim tehnikama isposobnošću da generiram svoja vlastita istraživanja što je dokazano mojim trenutnim postignutim znanstvenim rezultatima u postojećim suradnjama širom svijeta. Projekt ima četiri faze: 1. Prvo ćemo istražiti novu paradigmu asimptotske sigurnosti proširenja SM s glavnim ciljem formuliranja novih predviđanja za LHC Run-2. 2. S tim novim predviđanjima, cilj nam je proučavati temeljni problem masaneutrina. 3. U ovoj fazi, planiramo obaviti fenomenološke analize tih novih teorija koje vode do točnih predviđanja na ubrzivačima čestica. 4. Konačno, cilj nam je istraživati kozmološke posljedice tih novih modela s težištem naproučavanje tamne materije i bariogeneze.]]></summary_hr><summary_en><![CDATA[The European Community has invested heavily in the Large Hadron Collider (LHC) to solve fundamental problems within high energy physics. The LHC Run-2 period that begins now may prove to be the most exciting time for particle physics in 21th century as there are indications for existence of the new particles from the earlier LHC data. This proposal will contribute to solutions of fundamental problems within high energy physics in light of the new LHC data. The aim of this proposal is to address these problems by extending the Standard Model (SM) of strong, weak and electromagnetic interactions which is the currently accepted theoretical framework to describe interactions of fundamental particles. This is interesting because existing unsolved fundamental problems require new, beyond SM physics.The main criteria for success is a thorough understanding of the new experimental data by the strong theoretical team of the world’s leading researchers working at the interface between lattice supercomputing, field theoretical methods, beyond SM physics and cosmology.Together with my team, I will contribute with a variety of relevant techniques and ability to generate my own research proven by scientific results I currently achieved with existing collaborations worldwide.The project has four phases:1. First I will explore the new paradigm of the asymptotically safe extensions of the SM with the main goal to formulate new predictions for the LHC Run-2.2. With these new predictions, I aim to study the fundamental problem of neutrino mass.3. In this phase, I plan to perform phenomenological analysis of these new theories leading to accurate predictions for colliders.4. Finally, I aim to investigate cosmological implications of these new models with main focus on dark matter and baryogenesis.]]></summary_en></project><project>
<id>4473</id><title_hr><![CDATA[Značaj interakcija metalnih nanočestica sa sumpornim biomolekulama za nano-bio sučelje ]]></title_hr><title_en><![CDATA[Interaction of metallic nanoparticles with sulphur-containing biomolecules - implications for nano-bio interface ]]></title_en><user_id>573</user_id><user_firstLast_name>Ivana Vinković Vrček</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2016-06</proposal_call><code>IP-2016-06-2436</code><acronim><![CDATA[NanoFaceS]]></acronim><duration>15.03.2017 - 14.03.2021</duration><status>Završio</status><financ_value>120.090,25 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, Biologija, </scie_field_hr><scie_field_en>Chemistry, Biology, </scie_field_en><institution_hr><![CDATA[Institut za medicinska istraživanja i medicinu rada]]></institution_hr><institution_en><![CDATA[Institute for Medical Research and Occupational Health]]></institution_en><team_members_id>1223, 19873, 489, 549, 19641, 19592, 19620, 6307, 19860, 19818, 19612, 1503, 24035, 24031, 25203, </team_members_id><team_members_names><![CDATA[Mirta Milic, Sandra Šupraha Goreta, Goran Šinko, Ivan  Pavičić, Ante Miličević, Marija Milić, Barbara Vuković, Vatroslav Šerić, Daniel Horak, Enisa Omanović-Mikličanin, Ivona Capjak, Walter Goessler, Barbara Pem, Krunoslav Ilić, Rinea Barbir, ]]></team_members_names><keywords_hr><![CDATA[metalne nanočestice, sumporne biomolekule, nanomedicina, interakcije, vezanje]]></keywords_hr><keywords_en><![CDATA[metallic nanoparticle, sulphur containing biomolecules, nanomedicine, interactions, binding]]></keywords_en><summary_hr><![CDATA[Nanomedicina kao područje primjene nanotehnologije u razvoju zaštite zdravlja ima veliki utjecaj na razvoj inovativnih medicinskih tretmana i terapija. Primjena nanočestica (NP) ima ogroman potencijal za učinkovitiju isporuku lijekova i gena, u razvoju fluorescentnih i kontrastnih dijagnostičkih alatki u medicini. ...Međutim, opsežna in vivo primjena NP zahtijeva iscrpnije istraživanje fizikalno-kemijskih i fizioloških procesa koji se odvijaju u biološkim uvjetima. Takvo &#39;nano-bio&#39; sučelje obuhvaća dinamičke fizikalno-kemijske interakcije, te kinetiku i termodinamiku razmjene između površine nanočestica i bioloških površina. ...Nemoguće je potpuno opisati sve čimbenike značajne za to sučelje, ali su za daljnji razvoj nanomedicine nužne dodatne informacije o specifičnim interakcijama nanočestica s bioaktivnim komponentama prisutnim u živim stanicama i tkivima. Glavni cilj predloženog NanoFaceS projekta je pružiti nove  informacije o prirodi &#39;&#39;nano-bio &#39;sučelja između metalnih teranostičkih nanomaterijala i biomolekula koje sadrže sumpor (S-biomolekula), a koje imaju važnu i  kompleksnu funkcionalnu ulogu u živim sustavima. ...Modelni sustav NanoFaceS projekta čini (i) skup nanočestica s jezgrom od srebra, zlata i željezovog oksida,  različitih fizikalno kemijskih svojstava (veličine, površinskog naboja i kemijskog sastava) i (ii)  šest važnih S-biomolekula: cistein, glutation, metalotionein, albumin i inzulin. ... Konceptualni temelj predloženog projekta jest multimetodološki i multidisciplinarni pristup koji će pružiti nove uvide u prirodu specifičnih bioloških interakcija NP sa S-biomolekulama. Projekt će na taj način značajno doprinijeti znanju potrebnom za daljnji razvoj nanomedicinskog područja..........]]></summary_hr><summary_en><![CDATA[Nanomedicine, the application of nanotechnology to healthcare, has great impact on innovation of medical treatments and therapies. Nanoparticles (NPs) have an enormous potential in the medical arena as drug and gene delivery vehicles, fluorescent labels and contrast agents. ...However, extensive in vivo applications of NPs require a more exhaustive exploration of the physicochemical and physiological processes coupled with introduction of NPs to biological environments. The dynamic physicochemical interactions, kinetics and thermodynamic exchanges between NPs surfaces and the surfaces of biological components give rise to the ‘nano–bio’ interface. It is impossible to inevitably describe all events at this interface, but additional information on the more specific interplay of NPs with bioactive components of living cells and tissues are of the highest relevance for prospective evolution of nanomedicine....Proposed NanoFaceS project aims to provide a body of new information and new knowledge to the nanomedical endeavor in addressing the scientific uncertainties related to the beyond-state-of-the-art interaction of engineered metal-based NPs, used in theranostics, and sulfur-containing biomolecules (S-biomols), important in living systems due to their complex functional roles. NanoFaceS will use model system comprising (i) a set of silver, gold and iron oxide NPs with varying physico-chemical properties, i.e. size, surface charge and chemical composition and (ii) six representative S-biomols: cysteine, glutathione, metallothionein, albumin and insulin. ...The underlying concept of NanoFaceS will be based on understanding of interactions between NPs and S-biomols by implementing multimethodological and multidisciplinary approach which would yield competence on biological consequences of NPs interaction with S-biomols. As a major outcome, project will provide substantial knowledge to the nanomedical landscape....]]></summary_en></project><project>
<id>4474</id><title_hr><![CDATA[Metode i algoritmi za poboljšanje slika u boji u stvarnom vremenu]]></title_hr><title_en><![CDATA[Methods and algorithms for real-time color image enhancement]]></title_en><user_id>5393</user_id><user_firstLast_name>Sven Lončarić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2016-06</proposal_call><code>IP-2016-06-2092</code><acronim><![CDATA[PerfectColor]]></acronim><duration>01.03.2017 - 28.02.2021</duration><status>Završio</status><financ_value>123.963,10 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Elektrotehnika, Računarstvo, </scie_field_hr><scie_field_en>Electrical engineering, Computer sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id>6631, 25373, </team_members_id><team_members_names><![CDATA[Marko Subašić, Karlo Koščević, ]]></team_members_names><keywords_hr><![CDATA[obrada slike, poboljšanje slike, konstantnost boja, preslikavanje tonova, balans bijele boje]]></keywords_hr><keywords_en><![CDATA[image processing, image enhancement, color constancy, tone mapping, white balance]]></keywords_en><summary_hr><![CDATA[Poboljšanje slika u boji je važan problem u mnogim primjenama obrade slika. Razvoj senzora slike i rastuće potrebe tržišta za naprednim rješenjima koja su temeljena na tehnologijama obrade slika su glavni razlozi za sve veću važnost tehnika za poboljšanje slika. Algoritmi za obradu slika koji se koriste u ugradbenim računalnim sustavima kao što su digitalne kamere imaju oštra ograničenja s obzirom na rad u stvarnom vremenu te ograničenja tehnologije korištene za sklopovsku implementaciju, kao npr. FPGA tehnologija. Većina metoda i algoritama objavljenih u literaturi nisu prikladni za rad u stvarnom vremenu zbog njihove složenosti ili jer su neprikladni za sklopovsku izvedbu. Sveukupni cilj projekta je unaprjeđenje dviju važnih operacija za poboljšanje slika, algoritama za postojanost boja i preslikavanja intenziteta slike, koji su prisutni  u mnogim ugradbenim sustavima kao što su npr. digitalne kamere, kroz razvoj novih metoda za rad u stvarnom vremenu koje se i sklopovski daju učinkovito ostvariti. Glavni ciljevi ovog prijedloga su istraživanje i razvoj 1) metoda za postojanost boja koje rade u stvarnom vremenu i 2) metoda za preslikavanje intenziteta slike za rad u stvarnom vremenu. Uz to, bit će razvijene dvije nove baze slika koje će imati važan utjecaj na cijelu istraživačku zajednicu u području postojanosti boja. ]]></summary_hr><summary_en><![CDATA[Color image enhancement is an important problem in many image processing applications. Development of image sensors and growing market demand for advanced solutions that are based on the image processing technology are the main factors for increasing importance of image enhancement techniques. In particular, image processing algorithms used for embedded systems such as digital cameras have strict requirements in terms of real-time operation and hardware constraints imposed by specific technology used for embedded implementation, such as FPGA technology. Most methods and algorithms published in the literature are not suitable for real-time operation due to their complexity or due to being hardware unfriendly so their embedded implementations are too complex and unable to satisfy strict requirements of real-time applications. The overall goal of this project proposal is to improve two important image enhancement tasks of color constancy and tone mapping found in many embedded systems such as digital cameras by proposing new practically implementable methods that are capable of real-time operation. The main objectives of this research proposal are research and development of: 1) methods for real-time color constancy, and 2) methods for real-time tone mapping. In addition, two new image datasets that are to be created during this research, will certainly have an important impact on the whole research field of color constancy.]]></summary_en></project><project>
<id>4476</id><title_hr><![CDATA[Aktivnošću i in silico usmjeren dizajn malih bioaktivnih molekula]]></title_hr><title_en><![CDATA[Activity and in silico guided design of bioactive small molecules]]></title_en><user_id>5462</user_id><user_firstLast_name>Tomica Hrenar</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2016-06</proposal_call><code>IP-2016-06-3775</code><acronim><![CDATA[ADESIRE]]></acronim><duration>01.03.2017 - 28.02.2021</duration><status>Završio</status><financ_value>127.413,90 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, </scie_field_hr><scie_field_en>Chemistry, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>346, 19438, 19981, 5956, 6212, 20037, 19889, 25320, 28772, </team_members_id><team_members_names><![CDATA[Ines Primožič, Alma  Ramic, Linda  Mastelić, Renata  Odžak, Mirjana Skočibušić, Ricardo André Fernandes da Mata, Karlo Sović, Zlatan Spahić, Ana Mikelić, ]]></team_members_names><keywords_hr><![CDATA[dizajn bioaktivnih molekula, sinteza, bioaktivnost, molekularno modeliranje, doking, multi-way analiza]]></keywords_hr><keywords_en><![CDATA[design of bioactive small molecules, synthesis, bioactivity, molecular modelling, docking, multi-way analysis]]></keywords_en><summary_hr><![CDATA[U ovom projektu predložena je sinteza, karakterizacija i biološka evaluacija novih tipova spojeva te ekstenzivni kvantno-kemijski proračuni i multi-way analize. Bioaktivni kemijski skeletni tipovi kao što su benzimidazoli, imidazoli i kinuklidini prepoznati su kao spojevi sa širokim spektrom bioloških aktivnosti, također i u području infektivnih bolesti te poremećaja središnjeg živčanog sustava (Alzheimerova bolest, AD). Mi predviđamo da bi daljnja istraživanja tih klasa kemijskih spojeva mogla rezultirati s identifikacijom novih spojeva prikladnih za daljnji razvoj u moguće lijekove. Kao jako inovativni dio ovog istraživanja, a za razvoj točnih kvantitativnih modela povezivanja strukture i reaktivnosti bit će korištene napredne metode molekularnog modeliranja u kombinaciji s multi-way analizama. Ti modeli će se iskoristiti za iterativni postupak usmjerenog racionalnog dizajna. U početku će se korištenjem klasičnih i suvremenih metoda organske kemije sintetizirati novi bioaktivni spojevi. Za priređene kiralne spojeve odredit će se stereoselektivnost njihovih interakcija. Za sve spojeve, odredit će se antimikrobna aktivnost osobito prema rezistentnim Gram-negativnim bakterijama. Nadalje, njihov potencijal za razvoj poboljšanih lijekova za AD odredit će se mjerenjem njihove inhibicije kolinesteraza. Za procjenu mogućih pozitivnih sinergijskih učinaka, sintetizirat će se hibridne molekule te će se testirati i smjese najaktivnijih sintetiziranih spojeva. Molekularno modeliranje, doking simulacije i novorazvijena metodologija za primjenu multi-way analiza na kombinirane eksperimentalne i teorijske podatke koristit će se za ciljane strukturne promjene koje bi mogle dovesti do novih i efikasnijih bioaktivnih skeletnih tipova s potencijalnom primjenom u biotehnologiji, farmaceutskoj industriji i medicini.]]></summary_hr><summary_en><![CDATA[In this project synthesis, characterization, and biological evaluation of novel types of compounds including extensive quantum chemical calculations and multi-way analyses is proposed. Bioactive chemical scaffolds such as benzimidazoles, imidazoles, and quinuclidines are recognized as compounds with a broad spectrum of biological activities also in the fields of infectious diseases and central nervous system disorders (Alzheimer’s disease, AD). We envisioned that further exploration of these chemical classes can result with the identification of new leads suitable for further development into potential hits. As a highly innovative part of this study, advanced methods of molecular modelling combined with multi-way analysis will be used for construction of accurate quantitative structure–activity relationship models. These models will be used for iterative procedure of guided rational design. Initially, new bioactive compounds will be synthesized using classical and contemporary methods of organic chemistry. Chiral compounds will be prepared and the stereoselectivity of interactions evaluated. For all compounds, antimicrobial activity will be estimated targeting resistance genes to treat infections caused by multidrug-resistant Gram-negative bacteria. Furthermore, their perspective for development of enhanced anti-AD drugs will be assessed by determining their inhibitory potency toward cholinesterases. To evaluate possible beneficial synergistic effects, hybrid molecules as well as various combinations of the most active synthesized compounds will be prepared and tested. Molecular modelling, docking studies and a newly developed method for application of multi-way analysis to combined experimental and theoretical data will be used to direct structural changes leading to the synthesis of new, more efficient bioactive scaffolds with potential use in biotechnology, pharmaceutical industry and medicine.]]></summary_en></project><project>
<id>4481</id><title_hr><![CDATA[Napredno računalno modeliranje s ciljem smanjenja emisija razvojem Eulerove višefazne metode]]></title_hr><title_en><![CDATA[Advanced Computer Modelling for Emission Reduction by development of the Eulerian multiphase method]]></title_en><user_id>5040</user_id><user_firstLast_name>Milan Vujanović</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2016-06</proposal_call><code>IP-2016-06-1488</code><acronim><![CDATA[ACMER]]></acronim><duration>01.04.2017 - 31.03.2021</duration><status>Prekinut</status><financ_value>118.762,70 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Strojarstvo, Računarstvo, </scie_field_hr><scie_field_en>Mechnical engineering, Computer sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet strojarstva i brodogradnje]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Mechanical Engineering and Naval Architecture]]></institution_en><team_members_id>17236, 19762, 19763, 19760, </team_members_id><team_members_names><![CDATA[Tomaž Katrašnik, Marko Ban, Hrvoje Mikulčić, Zvonimir Petranović, ]]></team_members_names><keywords_hr><![CDATA[Računalne Simulacije, Višefazno strujanje, Sprej, Izgaranje, Emisije]]></keywords_hr><keywords_en><![CDATA[Computational Simulations, Multiphase flow, Spray, Combustion, Emissions]]></keywords_en><summary_hr><![CDATA[Kao rezultat izgaranja fosilnih goriva velika količina štetnih emisija ispušta se u atmosferu. Jedan način za smanjenje tih emisija je razvoj novih tehnologija izgaranja s poboljšanom učinkovitošću što se može postići kroz optimizaciju procesa raspršivanja i izgaranja goriva. Nadalje, s ciljem smanjenja emisija sve više značaja dobiva djelomična zamjena fosilnih goriva s novim gorivima kao što su biogoriva koja se smatraju CO2 neutralnima. Glavni cilj projektnog prijedloga je razvijanje napredne 3D računalne metode za simuliranje turbulentnih reaktivnih višefaznih strujanja. Predloženo istraživanje započet će razvojem i unaprjeđenjem modela raspadanja mlaza goriva, modela raspadanja i sudaranja kapljica te modela izgaranja goriva. Razvoj računalnih matematičkih modela predstavlja jednu od najsuvremenijih metoda u razvoju novih tehnologija izgaranja s poboljšanom učinkovitošću i smanjenim utjecajem na okoliš. Svi matematički modeli bit će razvijani unutar Euler Eulerovog višefaznog pristupa, što u kombinaciji s detaljnim kemijskim mehanizmima za opisivanje procesa izgaranja, čini novu i jedinstvenu metodu rješavanja višefaznih reaktivnih strujanja. S obzirom na trenutačno korištene metode, novo razvijena metoda bolje će opisivati procese u području gustog spreja što će rezultirati pouzdanim opisivanjem procesa izgaranja i stvaranja štetnih emisija. Novo razvijena metoda omogućit će detaljno modeliranje realnih inženjerskih sustava izgaranja. Rezultati dobiveni ovim projektom namijenjeni su razvoju novih tehnologija i konkretnom smanjenju emisija polutanata iz sektora industrije i transporta. Konačno, rezultati istraživanja bit će dostupni hrvatskom gospodarstvu te će se moći iskoristiti za unaprjeđenje njegove konkurentnosti na globalnom tržištu.]]></summary_hr><summary_en><![CDATA[As a result of fossil fuel combustion a vast amount of harmful pollutant emissions is released into the atmosphere. One way to reduce such emissions is the development of new combustion technologies with increased efficiency, which can be achieved through optimization of fuel spray and combustion processes. Furthermore, with aim to reduce emissions, more and more significance is given to partial fossil fuel replacement with new fuels such as bio-fuels which are considered CO2 neutral. The main goal of project is the development of an advanced 3D computational method for simulating turbulent reactive multiphase flows. The proposed project will start with development and enhancement of the mathematical models of jet atomization, droplet atomization, droplet collision and fuel combustion. The development of computer mathematical models represents state of the art method in development of new combustion technologies with increased efficiency and decreased environment impact. All mathematical models will be developed within the Euler Eulerian multiphase approach, which in combination with the detailed chemistry mechanisms for model the combustion process, defines new method for solving the multiphase reactive flows. Comparing to the commonly used methods, the new method will describe better the dense region processes which will result in reliable description of the combustion and emission formation processes. The newly developed method will allow research of real engineering combustion systems. The results from this project are intended for development of new technologies and specifically for reducing pollutant emission from industry and transport sector. Finally, research results will be available to Croatian economies and could be used for enhancing its competitiveness on the global market.]]></summary_en></project><project>
<id>4490</id><title_hr><![CDATA[INOVATIVNI FUNKCIONALNI PROIZVODI OD JANJEĆEG MESA]]></title_hr><title_en><![CDATA[INNOVATIVE FUNCTIONAL LAMB MEAT PRODUCTS]]></title_en><user_id>313</user_id><user_firstLast_name>Maja Popović</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2016-06</proposal_call><code>IP-2016-06-3685</code><acronim><![CDATA[INOJANJETINA]]></acronim><duration>01.03.2018 - 28.09.2023</duration><status>Završio</status><financ_value>113.249,32 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Veterinarska medicina, Javno zdravstvo i zdravstvena zaštita, </scie_field_hr><scie_field_en>Veterinary medicine, Public health and health services, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Veterinarski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Veterinary Medicine]]></institution_en><team_members_id>17525, 17314, 5662, 17577, 17508, 19485, 19874, 5510, 17509, 17472, 17605, 20163, 17484, 19396, 28633, 26966, 11258, </team_members_id><team_members_names><![CDATA[Miljenko Šimpraga, Ana Shek Vugrovečki, Daniel Špoljarić, Bela  Njari, Željka Cvrtila, Ivona Žura Žaja, Matko Kardum, Gordan Mršić, Lidija Kozačinski, Suzana Milinković Tur, Tomislav Mikuš, Ksenija Vlahović, Nina Poljičak Milas, Branimira Špoljarić, Luka Pajurin, Goran Kiš, Silvijo Vince, ]]></team_members_names><keywords_hr><![CDATA[plemenita pečurka, janje, nutritivna modulacija, funkcionalni proizvod, tehnologija mesa]]></keywords_hr><keywords_en><![CDATA[white button muschroom, lamb, nutrition modulation, functional produc, meat technologyi]]></keywords_en><summary_hr><![CDATA[Janjeće meso se odlikuje vrlo plemenitim okusom i mirisom te se navodi kao izvor biološki vrijednih proteina, vitamina B kompleksa i nekih minerala, lako je probavljivo te je izvanrednih dijetetskih osobina no meso ima relativno visok udio masti (7,8 g/100 g krtog mesa) i kolesterola (78 mg/100g krtog mesa).U ovom projektu naše prethodno znanstveno dokazane preporuke o sigurnom i djelotvornom uvođenju pripravka plemenite pečurke (PPP) u hranu za perad i svinje ispitati ćemo na modelu janjeta (što do sada nije poznato), te pri tome istovremeno predstaviti mogući tržišno novi proizvod (janjetine s nižim udjelima masti i kolesterola). U dosadašnjim istraživanjima zapazili smo snižavanje koncentracije kolesterola i glukoze u serumu ispitivanih ovaca hranjenih uz dodatak PPP no da li je isti učinak i na meso nije poznato. S obzirom na navedeno, cilj je ovoga projekta ocijeniti utjecaj dodatka PPP na kvalitetu mesa janjadi koje bi onda bilo pogodno kao sirovina za  proizvodnju funkcionalnih proizvoda koji se temelje na inovativnim rješenjima u tehnološkim postupcima proizvodnje.]]></summary_hr><summary_en><![CDATA[Lamb meat is characterized by a very noble taste and smell, and is cited as a source of biologically valuable proteins, vitamins of B complex and some minerals, easily digestible and with exceptional nutritional qualities. but the meat has a relatively high fat content (7.8 g/100 g lean meat) and cholesterol (78 mg/100g of lean meat). In this project our previous recommendations on scientifically proven safe and effective introduction of white button mushrooms (WBM) preparation in feed for poultry and pigs will be tested on the lamb model (which was not known until now). At the same time a possible new product on a market - lamb with lower fat and cholesterol levels, would be presented. That is because we have in our previous studies observed a reduction in plasma cholesterol and glucose levels of tested sheep fed with the addition of WBM preparation but whether the same effect is in the meat is not known. That being said, the goal of this project is to evaluate the influence of WHB feed supplementation on lambs meat quality which would then be suitable as a material for production of functional products based on innovative solutions in technological processes of production.]]></summary_en></project><project>
<id>4494</id><title_hr><![CDATA[Hrvatska znanstvena i filozofska baština: transferi i aproprijacije znanja od srednjeg vijeka do dvadesetog stoljeća u europskom kontekstu]]></title_hr><title_en><![CDATA[Croatian Scientific and Philosophical Heritage: Transfers and Appropriations of Knowledge from the Middle Ages to the Twentieth Century in the European Context]]></title_en><user_id>19067</user_id><user_firstLast_name>Željko Dugac</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2016-06</proposal_call><code>IP-2016-06-6762</code><acronim><![CDATA[HZIFBTIAZOSVDDSUEK]]></acronim><duration>20.03.2017 - 19.03.2021</duration><status>Završio</status><financ_value>77.500,92 eur</financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Povijest, Filozofija, </scie_field_hr><scie_field_en>History, Philosophy, </scie_field_en><institution_hr><![CDATA[Hrvatska akademija znanosti i umjetnosti]]></institution_hr><institution_en><![CDATA[Croatian Academy of Sciences and Arts]]></institution_en><team_members_id>20139, 20134, 19046, 1535, 268, </team_members_id><team_members_names><![CDATA[Marijana Borić, Bojan Marotti, Vedran Duančić, Branka Grbavac, Zrinka Blažević, ]]></team_members_names><keywords_hr><![CDATA[povijest znanosti, filozofija znanosti, transferi i aproprijacije znanstvenog znanja, srednji vijek, rani novi vijek, dvadeseto stoljeće]]></keywords_hr><keywords_en><![CDATA[history of science, philosophy of science, transfers and appropriations of scientific knowledge, middle ages, early modern period, twentieth century]]></keywords_en><summary_hr><![CDATA[Cilj istraživanja je kritički analizirati nove i neobjavljene izvore te ponuditi novi pogled na neke od najbitnijih i najutjecajnijih primjera transfera i aproprijacija znanstvenog znanja na hrvatskom prostoru od srednjega vijeka u širem međunarodnom i transnacionalnom kontekstu. Projekt istražuje aktivan proces aproprijacije od strane hrvatskih znanstvenika, njihov doprinos u različitim specifičnim lokalnim kontekstima, kao i na njihov doprinos globalnim znanstvenim procesima već prepoznatim u povijesti, filozofiji i sociologiji znanosti. Predloženi projekt istražuje specifične modalitete povijesnih transfera i aproprijacija znanstvenog znanja u kontekstu polu-perifernog položaja hrvatskih povijesnih teritorija, koji se očitovao u specifičnom položaju hrvatskih zemalja između mletačkih, osmanskih i habsburških imperijalnih sustava, kao i u liminalnom položaju tijekom Hladnog rata.]]></summary_hr><summary_en><![CDATA[The objective of the research is to critically analyze new and unpublished sources, and offer a new perspective on some of the most important and influential instances of transfers and appropriation of scientific knowledge in Croatia since the Middle Ages in a wider international and transnational context.  The research focuses on the active process of appropriation by scientists in/from Croatia, their contribution within a variety of specific local contexts as well as the impact in global processes recognized by history of philosophy and science. The proposed project examines the specific modalities of historical transfers and appropriations of scientific knowledge in connection to the Croatian semi-peripheral position, which was manifested in the position of Croatian lands between the Venetian, Ottoman, and Habsburg imperial systems and of an in-between position of Croatia and Yugoslavia for much of the Cold War.]]></summary_en></project><project>
<id>4495</id><title_hr><![CDATA[Transformacija rada u posttranzicijskoj Hrvatskoj]]></title_hr><title_en><![CDATA[Transformation of Work in Post-transitional Croatia]]></title_en><user_id>12526</user_id><user_firstLast_name>Reana Senjković-Svrčić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2016-06</proposal_call><code>IP-2016-06-7388</code><acronim><![CDATA[TRANSWORK]]></acronim><duration>01.04.2017 - 31.05.2021</duration><status>Završio</status><financ_value>63.756,06 eur</financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Etnologija i antropologija, </scie_field_hr><scie_field_en>Ethnology and anthropology, </scie_field_en><institution_hr><![CDATA[Institut za etnologiju i folkloristiku]]></institution_hr><institution_en><![CDATA[Institute of Ethnology and Folklore Research in Zagreb]]></institution_en><team_members_id>11205, 11288, 11210, 11211, 7812, 12631, 11206, 12897, 25145, </team_members_id><team_members_names><![CDATA[Tea Škokić, Ozren Biti, Orlanda Obad, Petar Bagarić, Ines Prica, Joško Ćaleta, Sanja Potkonjak, Mislav Žitko, Romana Pozniak, ]]></team_members_names><keywords_hr><![CDATA[transformacija, rad, posttanzicija, Hrvatska, etnografija rada]]></keywords_hr><keywords_en><![CDATA[transformation, work, post-transition, Croatia, ethnography of work]]></keywords_en><summary_hr><![CDATA[Na tragu kontinuiranog praćenja postsocijalističkih procesa predloženi projekt u hrvatsku etnologiju i kulturnu antropologiju uvodi subdisciplinu antropologije rada. Unutar interdisciplinarnog okvira oslonjenog na recentna postignuća europske antropologije, antropologije (post)socijalizma, antropologije rada, kritičkih studija rada, ekonomske antropologije itd., predložena konceptualna i neposredna etnografska istraživanja usredotočit će se na radnu svakodnevicu građana posttranzicijske Hrvatske. Istraživanja će pratiti dinamiku promjena i prilagodbi radne i životne ekonomije kroz efekte koji su u posttranzicijskoj Hrvatskoj dramatično promijenili iskustvo rada te će propitati nove kulturne imaginarije vezane uz ideju rada i projekciju budućnosti. Metodološki, projekt se temelji na empirijskim, etnografskim istraživanjima koja će se provesti na odabranim lokalitetima u Dalmaciji, Istri, Slavoniji, Baniji i u Zagrebu. Suradnici projekta TRANSWORK će, kvalitativnom metodom polustrukturiranih intervjua, razgovarati s informatorima o njihovim očekivanjima, ukoliko su zaposleni, o životu bez rada onih koji nisu zaposleni, o njihovom viđenju budućnosti, ali i o njihovim sjećanjima na rad i život kakav je nekad bio. Osim empirijskog dijela, projekt će se baviti i praćenjem koncepata i prakse rada u društvenopovijesnom kontinuitetu (od socijalističkog razdoblja do postsocijalističke periferije i krize neoliberalizma). Na osnovi arhivskih i teorijskih istraživanja, ali i izravnom metodom usmjerenih intervjua, ispitat će se koncepti, vrijednosti i praksa tradicionalnih modela rada koji sežu u socijalističko nasljeđe radničkog etosa te tranzicije industrijskog u aktualni, uslužni sektor djelatnosti.]]></summary_hr><summary_en><![CDATA[As part of the continual following of post-socialist processes the proposed project introduces to Croatian ethnology and cultural anthropology a sub-discipline of anthropology of work. Within the interdisciplinary framework based on the recent accomplishments of European anthropology, the anthropology of (post)socialism, anthropology of work, critical studies of work, economic anthropology etc., the proposed conceptual and ethnographic research will focus on the working everyday life of the citizens of post-transitional Croatia.The research will follow the dynamics of adjustment of the work and life economy in post-transitional Croatia through the effects that have dramatically changed the experience of work. It will examine new cultural imageries connected with the idea of work and projections for the future. The project will be based on empirical, ethnographic research method. Semi-structured interviews will be conducted at the selected locations in Dalmatia, Istria, Slavonia, Banija and in the town of Zagreb. The TRANSWORK team members will be interested in informants&#39; expectations, if they are employed, in their everyday life without work if they are unemployed, in their seeing of the future, but also in their memories of the life as it once was.In addition to the empirical part, project will be monitoring the concepts and work practices in social and historical continuity (spanning from the socialist period to the post-socialist periphery and the crisis of neo-liberalism). This includes archival and theoretical research, focused interviews of work models which derive from the socialist heritage of workers’ ethos, as well as professional and identity transitions into the industrial and service sector activities.]]></summary_en></project><project>
<id>4496</id><title_hr><![CDATA[Napredna monolitna i kompozitna keramika za zaštitu od trošenja i korozije]]></title_hr><title_en><![CDATA[Monolithic and composite advanced ceramics for wear and corrosion protection]]></title_en><user_id>900</user_id><user_firstLast_name>Lidija Ćurković</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2016-06</proposal_call><code>IP-2016-06-6000</code><acronim><![CDATA[WECOR]]></acronim><duration>01.05.2017 - 30.11.2021</duration><status>Završio</status><financ_value>111.487,16 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Strojarstvo, Kemijsko inženjerstvo, Temeljne tehničke znanosti, </scie_field_hr><scie_field_en>Mechnical engineering, Chemical engineering, Basic engineering sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet strojarstva i brodogradnje]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Mechanical Engineering and Naval Architecture]]></institution_en><team_members_id>1160, 2537, 4538, 2798, 4064, 12690, 23213, 23212, 23211, </team_members_id><team_members_names><![CDATA[Krešimir Grilec, Danko Ćorić, Vera Rede, Darko Landek, Irena Žmak, Sanda Rončević, Milan Vukšić, Ivana Sever, Zrinka Švagelj, ]]></team_members_names><keywords_hr><![CDATA[napredna keramika, Al2O3, Al2O3-ZrO2, lijevanje suspenzije, trošenje, korozija]]></keywords_hr><keywords_en><![CDATA[advanced ceramics, Al2O3, Al2O3-ZrO2, slip casting, tribology, corrosion ]]></keywords_en><summary_hr><![CDATA[Istraživat će se suspenzije za oblikovanje napredne mikro/nanostrukturirane monolitne Al2O3 i kompozitne Al2O3-ZrO2 keramike postupkom lijevanja i optimirat će se parametri postupka oblikovanja i sinteriranja. Glavne su prednosti oblikovanja lijevanjem suspenzije niski troškovi procesa, ekološka prihvatljivost, jednostavnost i fleksibilnost, potencijal za jednoliko slaganje čestica te prikladnost za proizvodnju dijelova složenog oblika. Istražit će se i mogućnost dobivanja mikro/nanoporozne Al2O3 keramike, tako da se dio sirovine zamijeni otpadnim Al2O3 prahom koji nastaje strojnom obradom sirovca. Na taj način postići će se uštede na sirovinama uz istovremeno zbrinjavanje otpada, tj. zaštitu okoliša.Provest će se: (i) istraživanje reoloških svojstava u ovisnosti o sastavu suspenzije, (ii) istraživanje utjecaja omjera Al2O3-ZrO2, veličina njihovih čestica, utjecaj vrste i količine aditiva na reološka svojstva suspenzija, kao i na mikrostrukturu, mehanička, tribološka i korozijska svojstva konvencionalno i mikrovalno (nekonvencionalno) sinterirane napredne monolitne i kompozitne keramike te (iii) utvrđivanje funkcionalne ovisnosti sastava i svojstava napredne keramike na bazi Al2O3 kao matrice, uz dodatak ZrO2 nanočestica.Matematičko modeliranje koristit će se za utvrđivanje utjecaja sastava, procesnih parametara i postignute strukture na mehanička, tribološka i korozijska svojstva napredne monolitne i kompozitne keramike.Očekivani rezultati: (i) razumijevanje i prikupljanje znanja o postupcima priprave suspenzije te doprinosa pojedinih komponenata suspenzije na svojstva keramičkog materijala, (ii) optimiranje suspenzija za lijevanje mikro/nanostrukturirane monolitne i kompozitne keramike (iii) razvoj napredne kemijski postojane kompozitne Al2O3-ZrO2 keramike s poboljšanom kombinacijom mehaničkih svojstava i otpornosti na trošenje u usporedbi s monolitnom Al2O3 keramikom te (iv) razvoj mikro/nanoporozne Al2O3 keramike oporabom industrijskog otpada.]]></summary_hr><summary_en><![CDATA[Suspensions for the slip casting of micro/nanostructured monolithic Al2O3 and composite Al2O3-ZrO2 advanced ceramics will be investigated, and slip casting and sintering parameters will be optimized. Main advantages of slip casting process are low costs, environmentally friendly process, simplicity and flexibility, potential for uniform particle packing and suitability for the production of parts of intricate shape. The possibility of production of the micro/nanoporous alumina by the replacement of a part of the raw material with the alumina waste obtained by green machining will be investigated. This will result in reducing raw materials costs and enhance waste management, i.e. environmental protection.The research will involve (i) study of rheological properties, depending on the suspension composition, (ii) study of the influence of Al2O3-ZrO2 ratio, particle size and type, and the amount of additives on the slip rheological properties as well as on microstructure, mechanical, tribological and corrosion properties of conventionally and microwave sintered advanced ceramics, and (iii) estimation of composition–property functional relationships of ceramics based on alumina matrix with the addition of nanosized zirconia.Mathematical modelling will be used for the determination of influence of composition, processing parameters and resulting structure on mechanical, tribological and corrosion properties of advanced ceramics.Expected outcomes: (i) understanding and gathering the know-how on the suspension preparation procedures, and the contribution of different components on the bulk properties of sintered samples, (ii) optimization of suspensions for slip casting of micro/nanostructured advanced ceramics, (iii) development of chemical resistant composite ceramics with an improved combination of mechanical properties and wear resistance compared to the alumina ceramics, (iv) development of the micro/nanoporous Al2O3 ceramics from industrial waste.]]></summary_en></project><project>
<id>4501</id><title_hr><![CDATA[Priobalna rastilišta: obrasci i procesi demografske varijabilnosti morskih riba uzduž istočnojadranske obale]]></title_hr><title_en><![CDATA[Coastal nursery habitats: Patterns and processes of demographic variability in marine fish species along the eastern Adriatic coast ]]></title_en><user_id>2707</user_id><user_firstLast_name>SANJA MATIĆ-SKOKO</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2016-06</proposal_call><code>IP-2016-06-9884</code><acronim><![CDATA[NurseFish]]></acronim><duration>15.03.2017 - 14.08.2021</duration><status>Završio</status><financ_value>117.194,24 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Biologija, </scie_field_hr><scie_field_en>Biology, </scie_field_en><institution_hr><![CDATA[Institut za oceanografiju i ribarstvo]]></institution_hr><institution_en><![CDATA[Institute of Oceanography and Fisheries]]></institution_en><team_members_id>1215, 4026, 4583, 4946, 3958, 5215, 124, 20129, 667, 19894, 27428, </team_members_id><team_members_names><![CDATA[Jakov Dulčić, Armin Pallaoro, Pero Tutman, Branko Dragičević, Dubravka Bojanić Varezić, Krešimir Markulin, Branko Glamuzina, Marcelo Kovačić, Melita Peharda Uljević, Dario Vrdoljak, Mišo Pavičić, ]]></team_members_names><keywords_hr><![CDATA[rastilište, nedorasle ribe, selidba, novačenje, otolit, geokemija, obala, estuarij]]></keywords_hr><keywords_en><![CDATA[nursery grounds, juvenile fish, settlement, recruitment, otolith, geochemistry, coast, estuary]]></keywords_en><summary_hr><![CDATA[Nažalost, mnoga priobalna staništa su pod povećanim okolišnim i antropogenim pritiscima i postoji  nedostatak saznanja o uzročno-posljedičnim odnosima tih pritisaka na morski ekosustav. Međutim, utvrđivanje takvih odnosa između širokog raspona stresnih čimbenika i njihovih učinaka na razini jedinke, vrste ili zajednice u morskom ekosustavu, je vrlo težak zadatak.Estuariji i priobalna područja se uobičajeno smatraju za visoko produktivne i vrijedne ekosustave. Istaknuta je njjihova uloga kao rastilišta za rane razvojne stadije mnogih vrsta. No, postoje  nejasni dokaz o važnosti obilježja staništa u u oblikovanju obrazaca dinamike populacija riba. Stoga, glavni istraživački ciljevi ovog projekta su šira prostorna procjena rastilišta riba uzduž obale srednjeg Jadrana, prostorno-vremenski trendovi u strukturi nedoraslih ribljih zajednica u rastilištima s međugodišnjom varijabilnosti u gustoći nedoraslih i jačine godišnje klase za određene gospodarski važne vrste riba; povezanost između estuarijskih i prioobalnih staništa preko elementarnih geokemijskih otisaka otolita  koji ukazuju na gibanja riba i vremensku konzistenciju individualnog doprinosa svakog pojedinog rastilišta obalnim područjima/populacijama riba. Također, analizirat će se vremenske promjene u strukturi nedoraslih ribljih zajednica unutar dva desetljeća s osnovnim matricama raznolikosti koje karakteriziraju promjene u taksonomskom sastavu zajednice kroz vrijeme, utvrđivanje da li je došlo do povećanja termofilnih vrsta i eventualno veća učestalost pelagičnih vrsta kako bi se osigurali dokazi za moguće faunističke promjene.Istraživanja u okviru predloženog projekta provodit će se duž istočne obale srednjeg Jadrana primjenom suvremenih metoda terenskog rada i analize. Projektni tim će izgraditi nove istraživačke kapacitete, a rezultati projekta u potpunosti će biti primjenjivi u upravljanju priobalnim ribarstvom na osnovu ekoloških principa i očuvanju biološke raznolikosti u Jadranu.]]></summary_hr><summary_en><![CDATA[Unfortunately, many of coastal habitats are under increasing environmental and anthropogenic pressures and there is a lack of data on causal relationships of these pressures on the marine ecosystems. However, establishing causal relationships between a wide range of stressors and effects at the individual, species or community level on marine ecosystems, is a difficult task.Estuaries and coastal areas are commonly acknowledged as highly productive and valuable ecosystems. Their role as nurseries for early life stages of many species has been highlighted. There is ambiguous evidence regarding the importance of habitat characteristics in driving patterns of fish population dynamics. Thus, the main research goals of this project are large-scale assessment of fish nursery grounds along the middle Adriatic coast, spatio-temporal trends in the structure of juvenile fish communities in nurseries with inter-annual variability in juvenile densities and year-class strength for certain economically important species; connectivity between estuarine and coastal habitats: through otolith elemental fingerprints unraveling fish movement and temporal consistence of individual nursery contributions to coastal areas. Also, temporal changes in juvenile fish assemblages structure over two decades with baseline of diversity metrics characterizing the change in taxonomic community composition through time, determining whether there has been an increase in warm-water affinity species and eventual higher incidence of pelagic species will be analyzed attempting to provide evidence for faunal changes. Research in the framework of the proposed project will be conducted along the middle eastern Adriatic coast applying modern fieldwork and analysis methods. The project team will build new research capacities while the results of the project are fully applicable for implementation in the ecology-based management of coastal fisheries and biodiversity conservation in the Adriatic Sea.]]></summary_en></project><project>
<id>4506</id><title_hr><![CDATA[Epigenetički biomarkeri u krvi i ejakulatu bolesnika sa seminomom testisa]]></title_hr><title_en><![CDATA[Epigenetic biomarkers in the blood and ejaculate of patients with testicular seminoma]]></title_en><user_id>3016</user_id><user_firstLast_name>Davor  Ježek</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2016-06</proposal_call><code>IP-2016-06-3692</code><acronim><![CDATA[epiSem]]></acronim><duration>01.08.2017 - 01.11.2021</duration><status>Završio</status><financ_value>129.802,91 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Kliničke medicinske znanosti, Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Clinical sciences, Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb School of Medicine]]></institution_en><team_members_id>1440, 3977, 3053, 3326, 19170, 13773, 20090, 19914, 3990, 4700, 19946, 641, 19217, 640, 19906, 2813, 4155, 19967, 4603, 7205, </team_members_id><team_members_names><![CDATA[Floriana Jakuš, Maja Vlahović, Ana Katušić Bojanac, Nino Sinčić, Jure Krasić, Jerka Dumić, Boris Ružić, Igor Tomašković, Tvrtko  Hudolin, Marija Gamulin, Miroslav  Tomić, Dinka Pavičić Baldani, Dejan Ljiljak, Lana Škrgatić, Nina Gelo, Davor Tomas, Marijana Ćorić, Monika Ulamec, Milan Milošević, Antonio Juretić, ]]></team_members_names><keywords_hr><![CDATA[tumori testisa, seminom, biomarkeri, epigenetika, slobodna DNA, metilacija DNA, varijacija broja kopija gena]]></keywords_hr><keywords_en><![CDATA[testicular tumors, seminoma, biomarkers, epigenetics, cell-free DNA, DNA methylation, gene copy number variation]]></keywords_en><summary_hr><![CDATA[Tumori zametnih stanica testisa (TGCT) najčešći su tumori mlađe muške populacije u svijetu. Naša epidemiološka studija iz 2011., pokazala je najviši trend porasta stope incidencije u svijetu te visok mortalitet u hrvatskoj populaciji. „Model-based“ istraživanja trendova rizika i demografskih kretanja iz 2014. ističu hrvatsku populaciju kao jednu od tri najugroženije u Europi te predviđaju da će u RH do 2025. jednom od 100 muškaraca godišnje biti dijagnosticiran TGCT. Upravo je seminom najčešći tip TGCTa, s trendom daljnjeg porasta. Smatra se da i (mikro)okolišni i (epi)genetski čimbenici dovode do njegova razvoja. Danas se epimutacije metilacije DNA kao tumorski biomarkeri ističu zbog svoje visoke frekvencije te izrazite kemijske i biološke stabilnosti, što im daje prednost u razvoju neinvazivne dijagnostike. Upravo se istraživanja biomarkera iz tjelesnih tekućina danas snažno potiču budući se taj koncept smatra jednim od temelja personalizirane medicine. Hipoteza je predloženog prospektivnog istraživanja da se u krvnoj plazmi i ejakulatu mogu identificirati biomarkeri seminoma na razini metilacije slobodne DNA. Usporedno s anamnestičkom i kliničkom obradom, sveobuhvatno istraživanje metilacije DNA provesti će se na uzorcima bolesnika prije i poslije terapijskog zahvata te rezultati usporediti s uzorcima zdravih muškaraca. Usporedba rezultata metiliranosti slobodne DNA i DNA tumora, kao i varijacije broja kopija gena, razjasnit će udio tumorske DNA u tjelesnim tekućinama, otkloniti pozadinski šum slobodne DNA zdravog tkiva te pokazati utjecaj genomskih aberacija na informativnost analize metilacije slobodne DNA. Usporedba ovih rezultata s proteinskom ekspresijom ispitivanih gena u seminomima u uzorcima istih bolesnika, razjasnit će odnos metoda suvremene molekularne patologije i predloženih novih pristupa u okviru razvoja personalizirane medicine. Očekuje se znanstveni doprinos u području razvoja epigenetičkih biomarkera u tjelesnim tekućinama onkoloških bolesnika.]]></summary_hr><summary_en><![CDATA[Testicular germ cell tumors (TGCTs) are the most common tumors of young male population worldwide. Our epidemiological study from 2011 showed Croatian population to have an increasing incidence trend which seems to be the steepest in the world, along with high mortality as well.  &#39;&#39;Model-based&#39;&#39; research of risks and demographic trends from 2014 highlights Croatian population as one of three most vulnerable in Europe, predicting that one of 100 Croatian men will be diagnosed with TGCT annually by 2025. The most frequent type of TGCT is seminoma, with further rising trend. It is believed that (micro)environmental and (epi)genetic factors lead to its development. DNA methylation epimutations as tumor biomarkers assert themselves because of their high frequency and extreme chemical and biological stability, giving them advantage in non-invasive diagnostics. Research of biomarkers from body fluids is strongly encouraged since it represents one of the basic elements of personalized medicine development. The hypothesis of proposed prospective study is that in the blood and ejaculate, seminoma specific biomarkers at the level of cell-free DNA methylation may be identified. Based on anamnestic and clinical data, comprehensive study of DNA methylation will be carried out in healthy men as well as patients, before and after therapeutic management. The study of cfDNA and DNA methylation in tumors, in addition to gene copy number variations, will clarify the proportion of tumor DNA in bodily fluids and show the impact of genomic aberrations in the analysis of cfDNA methylation. Comparison of these results with protein expression of tested genes in seminoma samples of same patients will clarify whether contemporary molecular pathology methods could be supplemented by the proposed new approach on the path of personalized medicine development. This study is expected to significantly contribute to the development of epigenetic biomarkers in body fluids of cancer patients.]]></summary_en></project><project>
<id>4511</id><title_hr><![CDATA[Procjena atmosverskog taloženja i razine ozona u mediteranskim šumskim ekosustavima]]></title_hr><title_en><![CDATA[Assessment of Atmospheric Deposition and Ozone levels in Mediterranean Forest ecosystems ]]></title_en><user_id>6636</user_id><user_firstLast_name>Tamara Jakovljević</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2016-06</proposal_call><code>IP-2016-06-3337</code><acronim><![CDATA[DepOMedFor]]></acronim><duration>01.03.2017 - 29.02.2020</duration><status>Završio</status><financ_value>78.439,18 eur</financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Šumarstvo, </scie_field_hr><scie_field_en>Forestry, </scie_field_en><institution_hr><![CDATA[Hrvatski šumarski institut]]></institution_hr><institution_en><![CDATA[Croatian Forest Research Institute]]></institution_en><team_members_id>848, 849, 6352, 3501, 3507, 19671, 12438, 13364, 12446, 20028, 25412, 25878, </team_members_id><team_members_names><![CDATA[Nenad Potočić, Ivan Seletković, Krunoslav Indir, Lukrecija Butorac, Goran  Jelić, Renato Buljan, Željko Zgrablić, Aldo Marchetto, Alessandra De Marco, Guillaume Simioni, Lucija Lovreškov, Ivan Limić, ]]></team_members_names><keywords_hr><![CDATA[atmosfersko taloženje, ozon, mediteranski šumski ekosustav, procjena, praćenje]]></keywords_hr><keywords_en><![CDATA[atmospheric deposition, ozone, mediterranean forest ecosystems, assessment, monitoring]]></keywords_en><summary_hr><![CDATA[Šumski ekosustavi se odlikuju izrazito promijenjivim uvjetima za rast i razvoja. Mediteranska regija čini se da je najosjetljivija na globalne promjene i atmosferske utjecaje. Mediteranski šumski ekosustavi su od velike važnosti zbog ekoloških funkcija koje pružaju. Rizik od utjecaja atmosferskih taloženja, erozija, klizišta i poplava je tako visok. Ovi faktori rizika u kombinaciji s klimatskim promjenama  vjerojatno utječu na ciklus nutrienta i hranidbe vrijednosti, vlažnost tla i, u konačnici, na rast i primarnu produktivnosti. Predloženo istraživanje će dati jedinstvenu mogućnost za analizu ne samo biogeokemijskim ciklus elemenata, na lokalnoj razini, nego i procjenu utjecaja onečišćenja na dijelove šumskog ekosusstava, te tijek od izvora do receptora. Da bi ostvarili ciljeve projekta uspostavit će se plohe za praćenje atmosferskih taloženje i razine ozonski na kojima će se vršti mjerenja mjeriti zajedno drugim varijablama, uključujući one koji se odnose na tlo i lišće te hranjiva, zdravstveni satus stabla, rast i stanje krošnje u kombinaciji s meteorološkim podacima. Mi ćemo dobiti potpuno nove, ali potrebne informacije koje nedostaju o atmosferskom taloženju, statusu hranjivih tvari, stvarnim opterećenjima, razini ozona i njegovih učinaka na šumama. Dodane vrijednosti ovog istraživanja će biti ispunjavanja praznina u znanju o naših mediteranskim šumskim ekosustavima i nadogradnju stečenog znanja s različitim statističkim metodama i budućih predviđanja kako bi se procijenilo stanje mediteranskih šumskih ekosustava. Rezultata ovog istraživanja i suradnje s talijanskim i francuski znanstvenim institucijama doprinijeti će široj osvrtu na utjecaje atmosferilija na mediteranske šumske ekosustave istočne obale Jadrana na regionalnoj i Europskoj razini.]]></summary_hr><summary_en><![CDATA[Forest ecosystems are characterized by strongly ?uctuating conditions for tree growth and development. The Mediterranean region appears to be the most vulnerable to global change and atmospheric inputs. Mediterranean forest ecosystems are of very high significance because of ecological functions they provide. The risk of impacts of atmospheric inputs, erosion, landslides and floods is being so high in this region. These risk factors combined with climate change is likely to affect nutrient turnover and nutrient availability, soil moisture and, ultimately, growth and primary productivity. The proposed research will give the unique possibility to analyse not only the biogeochemical cycle of elements, at local scale, but also the assessment of the environmental impact of pollutants on forest ecosystems compartments, following the uptake and the fate, from the sources to the receptors. In order to accomplish project objectives the monitoring plots will be established and atmospheric deposition and ozone levels will be measured together with a suite of other variables including those related to soil and foliar nutrient, tree health, growth and crown condition combined with meteorological data. We will get completely new but necessary missing information on atmospheric deposition, nutrient status, actual loads and ozone levels and its effects on forests. The added values of this research will be filling the gap in knowledge of our Mediterranean forest ecosystems and upgrading the gained knowledge with different statistical methods and future predictions in order to assess the condition of Mediterranean forest ecosystems.The results of this research and collaboration with Italian and French scientific institutions will contribute to the wider overview on impacts of atmospheric inputs in Mediterranean forests ecosystem of Eastern Adriatic coast at the regional and European level.]]></summary_en></project><project>
<id>4515</id><title_hr><![CDATA[BILJKE KAO IZVOR BIOAKTIVNIH SUMPOROVIH SPOJEVA TE NJIHOVA SPOSOBNOST HIPERAKUMULACIJE METALA]]></title_hr><title_en><![CDATA[PLANTS AS A SOURCE OF BIOACTIVE SULPHUR COMPOUNDS AND THEIR ABILITY TO HYPERACCUMULATE METALS]]></title_en><user_id>90</user_id><user_firstLast_name>Ivica Blažević</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2016-06</proposal_call><code>IP-2016-06-1316</code><acronim><![CDATA[BioSMe]]></acronim><duration>01.03.2017 - 31.08.2021</duration><status>Završio</status><financ_value>118.322,38 eur</financ_value><scie_area_hr>Prirodne znanosti, Biotehničke znanosti, Tehničke znanosti, </scie_area_hr><scie_area_en>Natural sciences, Biotechnical sciences, Technological sciences, </scie_area_en><scie_field_hr>Kemija, Kemijsko inženjerstvo, Biotehnologija, Prehrambena tehnologija, Nutricionizam, </scie_field_hr><scie_field_en>Chemistry, Chemical engineering, Biotechnology, Food technology, Nutrition, </scie_field_en><institution_hr><![CDATA[Sveučilište u Splitu, Kemijsko-tehnološki fakultet]]></institution_hr><institution_en><![CDATA[University of Split, Faculty of Chemistry and Technology]]></institution_en><team_members_id>403, 3364, 250, 13382, 19118, 19145, 19228, 19975, 5082, 3954, 122, 89, 25207, 23035, 5669, 100, </team_members_id><team_members_names><![CDATA[Tea  Bilušić, Sandra Svilović, Ivana Generalić Mekinić, Maša Buljac, Lea Kukoč Modun, Mario Nikola Mužek, Maja Biočić, Azra Đulović, Mirko Ruščić, Ivica Ljubenkov, Vedrana Čikeš Čulić, Joško Markić, Ivana Vrca, Marijana Popović, Nada  Bezić, Franko Burčul, ]]></team_members_names><keywords_hr><![CDATA[bioaktivni sumporovi spojevi, antioksidacijsko djelovanje, antitumorsko djelovanje, antimikrobno djelovanje, hiperakumulacija metala]]></keywords_hr><keywords_en><![CDATA[bioactive sulphur compounds, antioxidative activity, anticancer activity, antimicrobial activity, metal hyperaccumulation]]></keywords_en><summary_hr><![CDATA[Gotovo četvrtina svih farmaceutskih proizvoda u svijetu se dobiva iz biljaka. Biljni metaboliti sa sumporom uključuju raznolike kemijske strukture koji upravo zbog prisutnosti sumpora pokazuju određene fizikalno-kemijske značajke i međudjelovanja s različitim molekulskim i biološkim metama.Botanički red Brassicales, u koji ubrajamo brojne svakodnevno korištene vrste povrća (kupus, brokula, kapare itd.), je izrazito kemokarakteriziran prisutnošću tiosaharidnih sekundarnih metabolita-glukozinolata (GLa). GLi su spojevi koji se neprekidno istražuju, otkrivaju se i nove strukture pa danas ta grupa fitokemikalija broji oko 130 spojeva. Projekt će se usredotočiti na slabo ili prethodno neistražene samonikle vrste (endemske i dr.) iz reda Brassicales. GLi, koji su povezani s atipičnom endogenom glukohidrolazom-mirozinazom (E.C.3.2.1.147), djeluju kao bioprekursori biološki aktivnim izotiocijanatima te im je, u posljednjih 20 godina, posvećena posebna pozornost zbog korisnih učinaka na zdravlje. Specifični ciljevi ovog projekta uključuju njihovu izolaciju i biološka ispitivanja. Korisni biološki učinci biljaka koje sadrže sumporove derivate očituju se njihovom svakodnevnom upotrebom u prehrani. Kako bi spoj pokazao aktivnost in vivo, mora biti stabilan i biodostupan te će se isti istražiti u uvjetima simuliranog dvofaznog probavnog procesa korištenjem ljudskih probavnih enzima (želučani i crijevni). Istraživanje novih GLa i drugih biljaka koje sadrže biološki aktivne sumporove spojeve može potaknuti razvoj novih hortikulturalnih usjeva. Do danas je poznat veliki broj biljnih vrsta iz porodice Brassicaceae koje posjeduju sposobnost hiperakumulacije metala. Mnogi metali, ne samo da se hiperakumuliraju, već spadaju u esencijalne nutrijente pa se obogaćivanje hrane mikronutrijentima i fitoremedijacija mogu promatrati kao dvije strane istog novčića. Određivanje sposobnosti akumuliranja metala predstavlja jedan od bitnih aspekata uporabe ovih biljaka.]]></summary_hr><summary_en><![CDATA[Nearly quarter of all pharmaceutical products worldwide are derived from plant sources. Sulphur-containing plant metabolites include a variety of chemical structures which due to the presence of sulphur show particular physicochemical features and interact with a range of molecular and biological targets.The botanical order of the Brassicales-which encompasses many of our daily vegetables (cabbage, broccoli, capper etc.) is strikingly chemocharacterized by the presence of thiosaccharidic secondary metabolites-glucosinolates (GLs). GL investigation is an ongoing research activity and new structures have been documented, now including ca. 130 compounds. This project will focus on scarcely or previously not investigated wild-growing species (endemic and other) from the botanical order Brassicales.Associated with an uncommon endogenous glucohydrolase-myrosinase (E.C.3.2.1.147) GLs operate like precursors to biologically active isothiocyanates. Over the last 20 years these compounds have gained growing attention owing to their health-promoting properties. Specific focus of the project will involve their isolation and biological testing.The beneficial effects have been attributed to dietary consumption of sulphur containing vegetables. In order for any compound to exert an activity in vivo it is necessary to show stability and bioaccessibility. Thus they will be investigated under conditions of simulated two-step digestion process using human digestive enzymes (gastric and duodenal). Investigating novel GLs and other biologicaly active sulphur-containing plants may stimulate the development of new horticultural crops.As on to date many plants of Brassicaceae family are known to hyperaccumulate metals. As many of the metals that can be hyperaccumulated are also essential nutrients, food fortification and phytoremediation might be considered two sides of the same coin. Thus, analyzing plant capacity to accumulate metals represents one of the crucial aspects of plant usage.]]></summary_en></project><project>
<id>4518</id><title_hr><![CDATA[Epidemiologija hipertenzije i unos kuhinjske soli u Hrvatskoj ]]></title_hr><title_en><![CDATA[Epidemiology of hypertension and salt intake in Croatia]]></title_en><user_id>5508</user_id><user_firstLast_name>Bojan Jelaković</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2016-06</proposal_call><code>IP-2016-06-9033</code><acronim><![CDATA[EH-UH 2]]></acronim><duration>01.09.2017 - 31.08.2020</duration><status>Prekinut</status><financ_value>99.542,11 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Javno zdravstvo i zdravstvena zaštita, Kliničke medicinske znanosti, </scie_field_hr><scie_field_en>Public health and health services, Clinical sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb School of Medicine]]></institution_en><team_members_id>19655, 6539, 19729, 19621, 4373, 11291, 19610, 6805, 13257, 19640, 19825, 19632, 20029, 19681, 20221, 12396, 25935, </team_members_id><team_members_names><![CDATA[Ana Vrdoljak, Vanja Vasiljev Marchesi, Hrvoje  Tiljak, Ranko Stevanović, Jadranka  Sertić, Ivan Pećin, Sandra Karanovic, Aleksandar Džakula, Livija Šimičević, Lovorka Bilajac, Ivana Vukovic Brinar, Mirjana Fuček, Marion Tomičić, Danijela Štimac Grbić, Ines Balint, Živka Dika, Mihaela Marinović Glavić, ]]></team_members_names><keywords_hr><![CDATA[hipertenzija, kuhinjska sol, epidemiologija, prevalencija, svjesnost, liječenje, kontrola]]></keywords_hr><keywords_en><![CDATA[hypertension, salt intake, epidemiology, prevalence, awareness, treatment, control]]></keywords_en><summary_hr><![CDATA[Arterijska hipertenzija (AH) je vodeći uzrok pobola i smrti u svijetu pa tako i u Hrvatskoj.Prema podacima nacionalne EH-UH studije koja je završena prije 10 godina prevalencija je 37%, uz vrlo lošu kontrolu od oko 20%. Jedan od glavnih razloga velike prevalencije  i loše kontrole je prekomjeran unos kuhinjske soli koji prema rezultatima našeg istraživanja u Hrvatskoj iznosi preko 11 grama dnevno.Ti podaci su bili temelj za Strateški plan vlade Republike Hrvatske za smanjivanje prekomjernog unosa kuhinjske soli.Ciljevi ovoga projekta su:1)na temelju podataka iz arhive EH-UH 1 studije pozvati na kontrolni pregled sve ispitanike, pratiti klinički tijek i ishod ovisno o ulaznim pokazateljima;2)na način kako je rađeno u EH-UH 1 u EH-UH 2 skupini randomizirati novi uzorak opće populacije u cijeloj Hrvatskoj,koristiti isti upitnik,preglede,mjerenja arterijskoga tlaka i određivanja pridruženih čimbenika rizika te odrediti prevalenciju, svjesnost, liječenje i kontrolu hipertoničara, te odrediti dinamiku kretanja u Hrvatskoj tijekom perioda od 10 godina;3)u obje skupine (EH-UH1 i EH-UH2) odrediti unos kuhinjske soli mjerenjem 24-satne natriurije (zlatni standard za dnevnu procjenu unosa kuhinjske soli);4)u istom uzorku urina odrediti količinu joda kako bismo dobili podatak o sigurnosti smanjivanja unosa kuhinjske soli.Rezultati ovoga projekta omogućit će određivanje koji čimbenici najznačajnije utječu na progresiju AH i povezani su s fatalnim i nefatalnim ishodima;dobit ćemo podatak o dinamici kretanja prevalencije i kontroli AH u Hrvatskoj. Napose dobit ćemo podatak o kretanju unosa kuhinjske soli i povezanosti s AT, te o unosu joda. Dobiveni podaci koristit će kod planiranje strategija s ciljem podizanja kontrole AH i posljedično smanjivanja kardiovaskularnog, cerebrovaskularnog i renalnog rizika, a bit će važni i na međunarodnom planu u pregovorima Europskog društva za hipertenziju s Europskom komisijom.]]></summary_hr><summary_en><![CDATA[Hypertension (HT) is leading cause of morbidity and mortality worldwide and in Croatia. According to results from nationwide EH-UH study done 10 years ago, prevalence was 37%, with very poor control rate (20%). One of the major causes of high prevalence and poor control rate is excessive intake of salt. One of our study showed that the daily intake of salt in Croatia is around 11 grams. Data from that study were ground stone for Strategic Plan of the Government of Republic of Croatia for reducing excessive salt intake. Aims of this project are: 1) based on the archive of EH-UH 1 study do the follow-up of all the participants, to assess clinical course and outcome regarding entry data; 2) in EH-UH 2, following same methodology from EH-UH 1, to enroll new random sample of general population of entire Nation, use same questionnaire, means of physical exam and blood pressure measurements; to determine associated risk factors and to obtained prevalence, awareness, treatment and control rate of HT and to define the trend in Croatia in last 10 years; 3) salt intake will be assessed by measuring 24-hour natriuresis in both samples (EH-UH 1 and EH-UH 2), procedure considered to be the gold standard for daily table salt intake; 4) intake of iodine will be assessed from the same urine sample in order to avert suspicions that lowering salt intake will lead to  hypoiodinemia. Results from this research will help to define the factors with strongest impact on HT progression and are related with fatal and nonfatal events; data about prevalence and control rate of HT in Croatia will be obtained. Particularly, data on table salt intake and its impact on HT will be retrieve, along with iodine intake levels. Given data will be of use for planning further strategies for increasing HT control, and by that mean lowering overall cardiovascular cerebrovascular and renal risk. Also, data will suffice for European society of hypertension in its negotiations with European commission]]></summary_en></project><project>
<id>4524</id><title_hr><![CDATA[Optimizacijski i statistički modeli i metode prepoznavanja svojstava skupova podataka izmjerenih s pogreškama]]></title_hr><title_en><![CDATA[The optimization and statistical models and methods in recognizing properties of data sets measured with errors]]></title_en><user_id>895</user_id><user_firstLast_name>Rudolf Scitovski</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2016-06</proposal_call><code>IP-2016-06-6545</code><acronim><![CDATA[OSMoMeSIP]]></acronim><duration>01.03.2017 - 28.02.2021</duration><status>Završio</status><financ_value>80.230,94 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Matematika, </scie_field_hr><scie_field_en>Mathematics, </scie_field_en><institution_hr><![CDATA[Sveučilište Josipa Jurja Strossmayera u Osijeku, Fakultet primijenjene matematike i informatike]]></institution_hr><institution_en><![CDATA[Josip Juraj Strossmayer University of Osijek, School of Applied Mathematics and Informatics]]></institution_en><team_members_id>921, 3831, 2970, 6124, 19959, 3045, 19617, </team_members_id><team_members_names><![CDATA[Mirta Benšić, Kristian Sabo, Emmanuel Karlo  Nyarko, Petar Taler, Andrew Barron Barron, Dragan  Jukić, Safet Hamedović, ]]></team_members_names><keywords_hr><![CDATA[Optimizacija, Analiza velikih podataka, Grupiranje podataka, Dekonvolucija, Statistički modeli]]></keywords_hr><keywords_en><![CDATA[Optimization, Big data analysis, Data Clustering, Deconvolution, Statistical Models]]></keywords_en><summary_hr><![CDATA[U okviru projekta razmatraju se optimizacijski i statistički aspekti  prepoznavanja svojstava skupova podataka izmjerenih s pogreškama kao sastavni dio atraktivnog i aktivnog područja istraživanja poznatog kao analiza velikih podataka (engl. Big data analysis).  Istraživanja će biti usmjerena na  probleme grupiranja podataka te dekonvolucijske modele i primjene.  Polazi se od pretpostavke da  promatrani skupovi podataka  predstavljaju mjerene vrijednosti varijabli koje se analiziraju, ali u sebi sadrže grešku mjerenja. U velikim skupovima podataka vrlo često je prikladno podatke grupirati na temelju nekih karateristika te modelirati svaku grupu podataka posebnim modelima kojima se opisuju svojstva varijabli kao što su njihov  međusobni odnos, mogućnost separacije, rub skupa vrijednosti varijabli, oblik skupa vrijednosti varijabli, dimenzije (duljinu,  površinu ili volumen) skupa vrijednosti ili općenito vektor parametara kojim su te varijable određene. Problem se u mnogim konkretnim situacijama može formulirati u obliku optimizacijskog problema u kome kriterijska funkcija cilja općenito nije niti konveksna niti diferencijabilna.  U svrhu rješavanja takvih problema razvijat će se efikasne, brze i točne numeričke procedure. Također, zbog postojanja pogreške u podacima, u svrhu razumijevanja i pravilne interpretacije rezultata koristit će se statistički modeli te će se istražiti odgovarajuća statistička svojstva.  ]]></summary_hr><summary_en><![CDATA[As a part of an attractive and active area of research known as big data analysis, optimization and statistical aspects of recognizing data sets properties will be analyzed. Research will be focused on clustering problems, deconvolution models and applications. The assumption is that the observed data sets represent the measured values of the variables to be analyzed but also that they contain a measurement error. In large data sets it is often appropriate to cluster data sets on the basis of certain characteristics and then apply specific models for each group that can describe variable properties such as relationships among them, possibility of separation, edges, specific form of the set of values, dimensions (length, surface or volume) of the set of values or general parameter vector which determines them.  The problem in many practical situations can be formulated as an optimization problem for which the objective function is generally neither differentiable nor convex. In order to solve such problems effectively, rapid and accurate numerical procedures will be developed. Also, due to errors in the data, in order to understand and correctly interpret the results, statistical models will be used and important statistical properties will be characterized. ]]></summary_en></project><project>
<id>4526</id><title_hr><![CDATA[Metoda usvojenih deformacija za konačne elemente slojevitih ploča i ljuski i njena primjena na probleme delaminacije ]]></title_hr><title_en><![CDATA[Assumed strain method in finite elements for layered plates and shells with application on layer delamination problem]]></title_en><user_id>1014</user_id><user_firstLast_name>Dragan Ribarić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2016-06</proposal_call><code>IP-2016-06-4775</code><acronim><![CDATA[ASDEL]]></acronim><duration>01.03.2017 - 28.02.2021</duration><status>Završio</status><financ_value>81.301,75 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Temeljne tehničke znanosti, Građevinarstvo, </scie_field_hr><scie_field_en>Basic engineering sciences, Civil engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Građevinski fakultet u Rijeci]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Civil Engineering]]></institution_en><team_members_id>527, 906, 25238, 26077, 28914, </team_members_id><team_members_names><![CDATA[Gordan Jelenić, Leo Škec, Marin Grbac, Ivan Hlača, Maedeh Ranjbar Zefreh, ]]></team_members_names><keywords_hr><![CDATA[teorija ploča, metoda konačnih elemenata, usvojene interpolacije deformacija, uslojene ploče, uslojene ljuske, delaminacija]]></keywords_hr><keywords_en><![CDATA[plate theory, finite element method, assumed strain, layered plates, layered shells, delamination]]></keywords_en><summary_hr><![CDATA[Predlažemo istraživački projekt iz bazičnih tehničkih znanosti koji će se baviti numeričkim analizama Mindlinovih tipova umjereno debelih ploča pomoću metode konačnih elemenata. Temeljem naših dobrih rezultata kod dizajniranja četverostraničnih i trostraničnih pločastih elemenata (s različitim brojem čvorova) uz pomoć metode usvojenih interpolacija deformacija a za formuliranje njihove matrice krutosti, predlažemo proširenje istraživanja na uslojene ploče u 2D prostoru i uslojene ravne i zakrivljene ljuske u 3D prostoru.Materijal koji povezuje slojeve će se u početnoj fazi opisti elastičnim konstitutivnim zakonom, ali slijedom naših uspješnih numeričkih eksperimenata na uslojenim gredama, vezni materijal između slojeva će se u narednoj fazi opisati mješovitim konstitutivnim zakonom s kohezivnom zonom i oštećenjem. Ovaj tip povezivanja slojeva bit će kasnije primijenjen na sve tipove konstruktivnih modela – ploča, ravnih i zakrivljenih ljuski. Numerički rezultati bit će uspoređeni s rezultatima modela ili eksperimentalnim rezultatima drugih autora iz literature.Istovremeno, neka jednostavna eksperimentalna istraživanja izraditi će se s opremom iz naših laboratorija. U završnoj fazi, izvesti ćemo složene eksperimente na stvarnim modelima s delaminacijom slojeva, te i njih usporediti s odgovarajućim numeričkim modelima.]]></summary_hr><summary_en><![CDATA[We propose a research project in basic technical sciences concerning the numerical analysis of the Mindlin type moderately thick plates and shells by the finite element method.Given our good results in designing quadrilateral and the triangular plate elements (with various number of nodes) by the assumed strain interpolation in the element stiffness formulation, we propose to extend our research to the layered plates in 2D space and the layered facet or curved shells in 3D space. The material connecting the layers will be modeled at first with a simple elastic constitutive law, but following our successful numerical experiments on the layered beams, the interfaces between layers will be further modeled by a mixed-mode cohesive-zone damage-type constitutive law. This kind of interconnection behavior will be then applied to all kinds of structural models - plates, facet and curved shells. The numerical results will be compared with the other models and the experimental results from literature.At the same time, experimental research will be performed using the equipment in our laboratories. We shall try to perform experiments with delamination of the real layered models and also compare them with the appropriate numerical models.]]></summary_en></project><project>
<id>4528</id><title_hr><![CDATA[Računalno učinkovito upravljanje učinskim pretvaračima u mikromrežama]]></title_hr><title_en><![CDATA[Computationally Efficient Predictive Control of Power Converters in Microgrids ]]></title_en><user_id>5578</user_id><user_firstLast_name>Jadranko Matuško</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2016-06</proposal_call><code>IP-2016-06-2519</code><acronim><![CDATA[PowerCon2]]></acronim><duration>01.03.2017 - 29.02.2020</duration><status>Prekinut</status><financ_value>84.629,37 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Elektrotehnika, </scie_field_hr><scie_field_en>Electrical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id>2524, 7357, 20510, 25380, </team_members_id><team_members_names><![CDATA[Željko Jakopović, Fetah Kolonić, Tamara Hadjina, Renato Babojelić, ]]></team_members_names><keywords_hr><![CDATA[ Učinski pretvarači, Mikromreža, Modelsko prediktivno upravljanje, Izravno upravljanje snagom, FPGA]]></keywords_hr><keywords_en><![CDATA[Power converters, microgrid, Model predictive control, Direct power control, FPGA]]></keywords_en><summary_hr><![CDATA[Sve veći udio obnovljivih izvora u proizvodnji električne energije doveo je to pojave koncepta mikromreže. Mikromreža predstavlja skupinu distribuiranih i međusobno povezanih izvora, potrošača i spremnika energije i koja kao entitet može raditi spojena na distribucijsku mrežu ili potpuno odvojena od nje, tj. u tzv otočnom režimu rada. Tehnologija koja omogućuje jedan takav fleksibilan koncept su učinski pretvarači koji osiguravaju učinkovit i upravljan tok energije unutar mikromreže kao i prema distribucijskoj mreži. U zadnjoj dekadi modelsko prediktivno upravljanje se pojavilo kao metodologija koja omogućuje ne samo poboljšanje učinkovitosti rada učinskih pretvarača već i da se na sustavan način u proces projektiranja sustava upravljanja ugrade svi operativni zahtjevi, zahvaljujući jedinstvenom svojstvu da omogućava optimiranje radom sustava prema željenoj funkciji cilja, poštujući pritom sva ograničenja sustava. Glavna prepreka široj primjeni modelskog prediktivnog upravljanja u energetskim pretvaračima su značajni računski zahtjevi algoritma.Ovaj projekt ima za cilj razvoj računalno učinkovitih algoritama upravljanja mrežnim učinskim pretvaračima prikladnim za implementaciju u stvarnom vremenu. Projektni ciljevi su sljedeći: (i) razvoj računalno učinkovitog algoritma prediktivnog upravljanja mrežnim učinskim pretvaračem s PWM modulatorom, (ii) razvoj računalno učinkovitog algoritma prediktivnog izravnog upravljanja snagom mrežnog učinskog pretvarača (DPC) i (iii) implementacija i testiranje razvijenih algoritama na FPGA sklopovlju. Svi razvijeni algoritmi će biti implementirani  i testirani u istosmjernoj mikromreži u Laboratoriju za obnovljive izvore na Falultetu elektrotehnike i računarstva (LARES) ]]></summary_hr><summary_en><![CDATA[Increasing penetration of renewable sources in electricity generation has given rise to the concept of microgrids, a group of interconnected loads and distributed energy resources with clearly defined electrical boundaries that acts as a single controllable entity with respect to the grid connect and disconnect from the grid to enable it to operate in both grid-connected or islanded mode. An enabling technology for such the highly flexible concept are power converters, that allows for an efficient and well controlled energy flow within microgrid and to/from the main grid. In the last decade model predictive control has emerged as a methodology that is capable not only to further increase the efficiency of energy conversion but also to systematically integrate control and operational requirements into control system design process, owing to its unique feature to optimize system behaviour over an arbitrary objective function while respecting the system constraints at the same time. The main obstacle to broader applications of MPC based algorithms in power converters is the significant computational burden of the MPC algorithm. This project aims to develop computationally efficient algorithms for grid connected power converters suitable for real time-implementation.  In particular, the project aims: (i) to develop a computationally efficient PWM based predictive control algorithm for grid-tied power converters, (ii) to develop a computationally efficient Predictive Direct Power Control algorithm for grid-tied power converters and (iii) to implement the developed control algorithm for grid-tied power converters into high performance hardware platforms such as Field Programmable Gate Array (FPGA). All the developed control algorithms will be implemented and tested in a small scale DC microgrid in the Laboratory for Renewable Energy Sources (LARES) at Faculty of electrical Engineering and Computing, Zagreb.  ]]></summary_en></project><project>
<id>4529</id><title_hr><![CDATA[Lokalno ekološko znanje i ribarstvena istraživanja u Hrvatskoj: promjene u ribolovnoj i biološkoj raznolikosti mora ]]></title_hr><title_en><![CDATA[Local Ecological Knowledge and Fisheries Research in Croatia: Fishing and Marine Biodiversity Changes ]]></title_en><user_id>1215</user_id><user_firstLast_name>Jakov Dulčić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2016-06</proposal_call><code>IP-2016-06-5251</code><acronim><![CDATA[LEK-FishRes-CRO]]></acronim><duration>01.03.2017 - 31.08.2021</duration><status>Završio</status><financ_value>111.354,44 eur</financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Biotehnologija, Poljoprivreda, </scie_field_hr><scie_field_en>Biotechnology, Agriculture, </scie_field_en><institution_hr><![CDATA[Institut za oceanografiju i ribarstvo]]></institution_hr><institution_en><![CDATA[Institute of Oceanography and Fisheries]]></institution_en><team_members_id>4583, 2707, 20129, 3958, 668, 13709, 7025, 669, 283, 3959, 4946, </team_members_id><team_members_names><![CDATA[Pero Tutman, SANJA MATIĆ-SKOKO, Marcelo Kovačić, Dubravka Bojanić Varezić, Vanja Čikeš Keč, Igor Isajlović, Nedo Vrgoč, Barbara Zorica, Svjetlana Krstulović Šifner, Nika Stagličić, Branko Dragičević, ]]></team_members_names><keywords_hr><![CDATA[Jadransko more, ribarstvo, bioraznolikost, lokalno ekološko znanje, indikatorske vrste]]></keywords_hr><keywords_en><![CDATA[Adriatic Sea, fishery, biodiversity, local ecological knowledge, indicator species]]></keywords_en><summary_hr><![CDATA[Lokalno Ekološko Znanje (LEZ) je uvaženo kao alternativni izvor informacija o prisutnosti termofilnih i ne-zavičajnih vrsta te kvalitativnih i kvantitativnih pokazatelja njihove brojnosti. Pojave ne-zavičajnih vrsta sve se češće bilježe u Jadranu, što naglašava hitnost potrebe da se osigura odgovarajuće praćenje, brzo otkrivanje i brzo djelovanje. Središnji cilj projekta je procjena  potencijalne upotreba LEZ u razvoju baza znanja za upravljanje ribarstvom i zaštitom živih bogatstava mora. Strategija za ovu evaluaciju će biti dvosmjerna rasprava između ribara i drugih zainteresiranih dionika s jedne strane, te biologa s druge strane, oko određivanja indikatora o stanju ekosustava. U ovom projektu možemo razlikovati: Cilj 1: Razvoj i primjena LEZ intervju protokola (anketno ispitivanje), Cilj 2: Analiza podataka i usporedba podataka temeljenih na IZ s onima prikupljenim anketnim ispitivanjem LEZ, Cilj 3: Identifikacija tropikalizacije/meridionalizacije te promjena abundancije indikatorskih vrsta s naglaskom na invazivne vrste: pružanje osnovnih biološko-ribarstvenih podataka za pravovremeni odgovor. Ti ciljevi podrazumijevaju stvaranje proširene baze znanja za učinkovito upravljanje u ribarstvu, uključujući razmatranje ekosustava kao cjeline i obnove baze resursa za ribarstvo. Očekivani rezultati će nam dati uvid da li je LEZ prikladan način za rekonstrukciju ekoloških procesa (identifikaciju indikatora meridionalizacije/tropikalizacije, rekonstrukciju povijesnih trendova abundancije za indikatorske vrste/praćenje invazije alohtonih vrsta). Također ćemo moći procijeniti da li je LEZ protokol pogodan za otkrivanje značajnih promjena u morskom ekosustavu i da li je dovoljno robustan da pruži pouzdane podatke koji bi mogli poslužiti kao polazište za odgovarajuće aktivnosti. Očekujemo da će se odrediti biološke, ekološke i ribarstvene osobine najvažnijih vrsta indikatora u kontekstu ribarstva kao  i procesa meridionallizacije/tropikalizacije/invazije.]]></summary_hr><summary_en><![CDATA[Local Ecological Knowledge (LEK) is appreciated as an alternative source of information about the presence of thermophilic and non-indigenous species (NIS) and the qualitative and quantitative indicators of their numbers. The appearance of NIS are increasingly recorded in the Adriatic, which emphasizes the urgency of the need to ensure adequate monitoring, early detection and rapid action. The central objective of the project is to assess the potential use of LEK in the development of a knowledge base for fisheries management and protection of living marine resources. The strategy for this evaluation will be a two-way discussion between the fishermenand biologists about the determination of indicators of the ecosystem state. In this project, we can distinguish 3 objectives: Development and application of LEK Interview-protocol (survey questionnaire), Data analysis and comparison of research based knowledge (RBK) with LEK surveys data, Identification of tropicalization/meridionalization and abundance change for indicator species with emphasis on invasive species: providing baseline biological fisheries data for timely response. These objectives include the creation of an extended knowledge base for effective fisheries management. The expected results will give us insight into whether the LEK is convenient way for the reconstruction of ecological processes (identification of  indicator of meridionalization/tropicalisation, reconstruction of historical trends abundance of indicator species and invasion of NIS). We will also be able to assess whether the LEK protocol is suitable for the detection of significant changes in the marine ecosystem and is robust enough to provide reliable data that could serve as a starting point for the relevant activities. We expect to determine the biological, ecological and fishery characteristics of the most important types of indicators in the context of fisheries and processes of meridionallization/tropicalisation/invasion.]]></summary_en></project><project>
<id>4530</id><title_hr><![CDATA[Upravljanje dinamičkim sustavima]]></title_hr><title_en><![CDATA[Control of Dynamical Systems]]></title_en><user_id>866</user_id><user_firstLast_name>Martin Lazar</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2016-06</proposal_call><code>IP-2016-06-2468</code><acronim><![CDATA[ConDyS]]></acronim><duration>01.03.2017 - 31.08.2021</duration><status>Završio</status><financ_value>131.926,47 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Matematika, </scie_field_hr><scie_field_en>Mathematics, </scie_field_en><institution_hr><![CDATA[Sveučilište u Dubrovniku]]></institution_hr><institution_en><![CDATA[University of Dubrovnik]]></institution_en><team_members_id>5431, 19770, 844, 5167, 19723, </team_members_id><team_members_names><![CDATA[Ivica Nakić, Ivana Palunko, Zoran Tomljanović, Domagoj Tolić, Irena Brdar, ]]></team_members_names><keywords_hr><![CDATA[upravljanje, parametarski-ovisni sustavi, vibracijski sustavi, adaptivno dualno upravljanje, optimalni dizajn]]></keywords_hr><keywords_en><![CDATA[control, parameter dependent problems, vibrational systems, adaptive dual control, optimal design]]></keywords_en><summary_hr><![CDATA[Ovim se projektom unutar hrvatske istraživačke mreže planira uspostaviti tim znanstvenika koji će se baviti matematičkom teorijom upravljanja i moći odgovoriti na najsuvremenije izazove povezane s problemima iz stvarnog života. Teorija upravljanja interdisciplinarno je područje koje povezuje matematiku s tehničkim znanostima i proučava dinamičke sustave s ulazima. Rezultati iz teorije upravljanja uspješno su primijenjeni na mnoge konkretne zadaće iz područja kao što su elektrotehnika, strojarstvo, transport, komunikacije, medicina itd. Iako postojeća teorija pruža odgovore na brojna fundamentalna i praktična pitanja, mnogi važni problemi su i dalje nerazriješeni. Daljnji napredak u modeliranju i upravljanju (fizičkim ili ekonomskim) sustavima povezan je s razvojem sofisticiranih matematičkih alata.U srži zanimanja projekta bit će značajne teme privlačne s teorijskoga, numeričkog i primijenjenoga gledišta, posebice: upravljanje vibracijskim i parametarski ovisnim sustavima, adaptivno dualno upravljanje, trošak upravljanja u višeskalnim zadaćama, optimalni dizajn i upravljanje autonomnim sustavima. Dobiveni rezultati bit će primijenjeni na probleme zračnih isporuka, čovjek-robot suradnje, upravljanja prometom itd. Spomenute teme i primjene važne su točke u tekućim međunarodnim istraživanjima a članovi skupine već imaju iskustva u radu na njima.Cilj je projekta pružiti nove teorijske metode i rezultate, analizirati pripadna numerička pitanja, razviti prikladni računski softver i potvrditi primjenu novorazvijenih metoda na sustavima koji proizlaze iz praktičnih problema, na taj način premošćujući međuprostor između teorijskih razmatranja i industrijskih primjena.U istraživanju ćemo, između ostalog, upotrebljavati pohlepne algoritme, redukciju modela, dvokriterijsku sintezu, Carlemanove nejednakosti, homogenizaciju, H-mjere, racionalne Krilovljeve metode, Pontrjaginov princip, teoriju Ljapunovljeve stabilnosti, poluklasičnu i harmonijsku analizu, te Liejeve grupe.]]></summary_hr><summary_en><![CDATA[This project aims at establishing a strong group in mathematical control theory within the Croatian research network, able to address cutting-edge issues emerging from real-life problems. Control theory is an interdisciplinary field combining engineering and mathematics that analyses dynamical systems with inputs. Results from control theory have been successfully applied to many problems in fields such as electrical and mechanical engineering, transportation, communication, medicine etc. Although the existing theory provides answers to a number of fundamental and practical questions, many important problems are still unresolved. In order to model and control (physical or economic) systems as closely as possible, there is an increasing demand for a sophisticated mathematical apparatus.The project will focus on the highly relevant topics attracting attention from theoretical, numerical and applicational points of view, in particular: control of vibrational and parameter dependent systems, adaptive dual control, cost of control in a multiscale setting, optimal design and control of autonomous systems. The results will be applied to problems of aerial delivery, human-robot cooperation, traffic control etc. This choice of topics is influenced by their importance in the current international research as well as by the background and expertise of the team members.The goal of the project is to provide new theoretical methods and results, analyse the related numerical issues, develop new computational software and verify applications of the newly developed methods to systems based on real-life scenarios, thereby bridging the gap between theoretical considerations and industrial applications.The tools and techniques we will use include greedy algorithms, model reduction, bicriterial synthesis, Carleman inequalities, homogenisation, H-measures, semi-classical and harmonic analysis, rational Krylov methods, Pontryagin principle, Lyapunov stability theory, and Lie groups.]]></summary_en></project><project>
<id>4533</id><title_hr><![CDATA[Prognostička vrijednost i dinamika cirkulirajuće mikroRNA u visokorizičnom mijelodisplastičnom sindromu liječenom 5-azacitidinom]]></title_hr><title_en><![CDATA[Prognostic significance and dynamics of circulating microRNA in high-risk MDS patients treated with 5-azacitidine ]]></title_en><user_id>19353</user_id><user_firstLast_name>Slobodanka Ostojić Kolonić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2016-06</proposal_call><code>IP-2016-06-5842</code><acronim><![CDATA[MDSmicroRNA]]></acronim><duration>20.03.2017 - 19.03.2021</duration><status>Prekinut</status><financ_value>17.604,35 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Kliničke medicinske znanosti, </scie_field_hr><scie_field_en>Clinical sciences, </scie_field_en><institution_hr><![CDATA[Klinička bolnica "Merkur", Zagreb]]></institution_hr><institution_en><![CDATA[Merkur Clinical Hospital, Zagreb]]></institution_en><team_members_id>19347, 19490, 19044, 19370, 20299, 19736, 3792, 20227, 20183, </team_members_id><team_members_names><![CDATA[INGA MANDAC ROGULJ, Martina Bogeljić Patekar, Vibor Milunović, Mirjana Mariana Kardum Paro, MARKO MARTINOVIĆ, ZORAN ŠIFTAR, Biljana Jelić Puškarić, ANA PLANINC PERAICA, Goran Rincic, ]]></team_members_names><keywords_hr><![CDATA[mijelodisplastični sindrom, microRNA, 5-azacitidin, prognostički faktori,visoki rizik ]]></keywords_hr><keywords_en><![CDATA[myelodysplastic syndrome, microRNA, 5-azacitidine, prognostic factors, high risk]]></keywords_en><summary_hr><![CDATA[Mijelodisplastični sindrom (MDS) predstavlja najučestaliju hematološku neoplazmu starije životne dobi. Karakteriziran je s jednom ili više citopenija te mogućnosti transformacije u sekundarnu akutnu mijeloičnu leukemiju.MikroRNA (miRNA) je podvrsta nekodirajućih RNA čija glavna funkcija leži u inhibiciji translacije mRNA preko različitih mehanizama u stanici. Cirkulirajuća miRNA se putem staničnih vezikula ili staničnom smrti otpušta u perifernu krv. Usprkos sve većem istraživanju cirkulirajuće miRNA u različitim entitetima, samo nekoliko studija je istražilo njezinu povezanost s MDS-om što čini racional predloženog projekta. Glavni cilj ove studije je istražiti ekspresiju i dinamiku ekspresije cirkulirajuće miRNA te njezin prognostički značaj u uniformnoj skupini 40 bolesnika s visokorizičnim MDS-om definiranim kao „INT-2“ i „High“ prema IPSS bodovnom sustavu liječenih 5-azacitidinom.. U studiji će biti određivane sljedeće miRNA: let-7-a, miRNA-21, miRNA-144, i miRNA-125a. Ove miRNA će biti određivane u multiplim vremenskim točkama studije: pri dijagnozi, nakon 4. i 6. ciklusa liječenja 5-azacitidinom, pri relapsu te leukemijskoj transformaciji kako bismo dobili uvid u alteraciju ekspresije cirkulirajućih miRNA zbog uvida u tijek i liječenje MDS-a.Specifični ciljevi studije su: usporediti ekspresiju cirkulirajućih miRNA u bolesnika s visokorizičnim MDS-om pri dijagnozi s ekspresijom cirukulirajućih miRNA u zdravih bolesnika, ispitati povezanost ekspresije cirkulirajuće miRNA s kliničkim i morfološkim karakteristikama bolesnika s visokorizičnim MDS-om pri dijagnozi i tijekom liječenja 5-azacitidinom te usporediti ekspresiju cirkulirajuće miRNA pri dijagnozi i leukemijskoj transformaciji MDS-a. S obzirom na činjenicu da je istraživanje cirkulirajućih miRNA u MDS-u tek na početku, ova studija bi mogla definirati pojedine miRNA koje bi u idućim istraživanjima mogle biti neivazivan i lako dostupan biomarker u prognozi  i liječenju MDS-a.]]></summary_hr><summary_en><![CDATA[Myelodysplastic syndrome (MDS) is the most common hematological neoplasm of elderly. It is characterized by one or more cytopenias and the possibility of transforming to the secondary acute myeloid leukemia.MicroRNAs (miRNA) is a sub-coding RNA whose main function is to inhibit translation of mRNA via different mechanisms in the cell. Circulating miRNA is released via cellular vesicles or  after cell death  into the peripheral blood. Despite growing research circulating miRNA in different entities, only a few studies have examined its association with MDS which makes rational of the proposed project.The main objective of this study was to investigate the expression and dynamics of circulating miRNA expression and its prognostic significance in uniform group of 40 patients with high-risk MDS defined as &#39;&#39;INT-2&#39;&#39; and &#39;&#39;High&#39;&#39; according to the IPSS scoring system treated with 5-azacitidine. The study will  analyze following miRNAs: let-7, a miRNA-21, miRNA-144 and miRNA-125a. These miRNA will be determined at multiple time points of the study: at diagnosis, after 4 and 6 cycles of treatment 5-azacitidine in relapse and leukemic transformation in order to get insight into the alteration of expression of circulating miRNA for insight into the course and treatment of MDS.The specific objectives of the study are: to compare the expression of circulating miRNA in patients with high-risk MDS at diagnosis and  in healthy patients, examine the relationship between circulating miRNA expression with clinical and morphological characteristics of patients with high-risk MDS at diagnosis and during treatment with 5-azacitidine and to compare the expression of circulating miRNA in diagnosis and leukemic transformation of MDS. Given the fact that the investigation of circulating miRNAs  in MDS is just beginning, this study could define specific miRNA that in future research could be noninvasive  and readily available biomarker in the prognosis and treatment of MDS.]]></summary_en></project><project>
<id>4546</id><title_hr><![CDATA[Istraživanja početka plastičnog toka metala kod hladne deformacije ]]></title_hr><title_en><![CDATA[Study of the Beginning of Plastic Flow of Metals During Cold Deformation]]></title_en><user_id>1351</user_id><user_firstLast_name>Stoja Rešković</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2016-06</proposal_call><code>IP-2016-06-1270</code><acronim><![CDATA[MFSRIP062016]]></acronim><duration>01.03.2017 - 29.02.2020</duration><status>Završio</status><financ_value>55.325,50 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Metalurgija, </scie_field_hr><scie_field_en>Metallurgy, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Metalurški fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Metallurgy]]></institution_en><team_members_id>3259, 19619, 19755, 274, 1332, 4702, 19501, 652, 24856, 24864, 24878, 25774, </team_members_id><team_members_names><![CDATA[Ladislav Lazić, Debruyne Dimitri, Pascal Lava, Suzana Jakovljević, Ivan Jandrlić, Tamara Aleksandrov Fabijanić, Tin Brlić, Ljerka Slokar, Vjeran Furlan, Filip  Skender, Karlo Komosar, Miloš Matvija, ]]></team_members_names><keywords_hr><![CDATA[čelik, hladna deformacija, orijentacija zrna, niobijevi precipitati, brzina deformacije, Lüdersove linije,  termografija, DIC]]></keywords_hr><keywords_en><![CDATA[steel, cold deformation, niobium precipitates, strain rate, Lüders bands, thermography, DIC]]></keywords_en><summary_hr><![CDATA[Razvojem suvremenih metoda ispitivanja danas se u svijetu provode istraživanja toka materijala i raspodjele naprezanja u zoni deformacije. Posebna pozornost posvećuje se istraživanju početka plastičnog toka materijala, naročito u elastoplastičnom području. Zapaženo je da kod nekih niskougljičnih čelika i Al legura, nakon dostizanja granice proporcionalnosti, dolazi do pojave L?dersovih linija.  Različita su tumačenja  ove pojave. U ovom projektu provesti će se istraživanje na niskougljičnom i istom čeliku mikrolegiranom s različitim sadržajem niobija. Provesti će se istraživanja na čeliku istog kemijskog sastav a koji imaju različitu veličinu i raspored niobijevih precipitata. Primjenom suvremenih metoda visioplastičnosti, termografije, digitalne korelacije slike, te pretražne i transmisijske elektronske mikroskopije istražiti će se utjecaj niobija na početak i tok deformacije. Istodobno sa statičkim vlačnim pokusom provesti će se mjerenja s termografskom i optičkom kamerom. Istražiti će se utjecaj različitih parametara (brzine deformacije, stupnja deformacije, sadržaja mikrolegirajućeg elementa niobija, veličine i rasporeda niobijevih precipitata) na elastično, elastoplastično i plastično ponašanje čelika, te formiranje zone deformacije i raspodjelu naprezanja u zoni deformacije. Posebna pozornost će se posvetiti istraživanju utjecajnih parametara na formiranje i propagaciju Lüdersovih linija u elastoplastičnom području. Istražiti  će se utjecaju početne strukture,  veličine i orijentacije zrna na pojavu i propagaciju L?dersovih linija. Detaljno će se istražiti strukturne promjene koje nastaju u čeliku kod formiranja Lüdersove linije i u različitim fazama njene propagacije kroz zonu deformacije, pri različitim brzinama deformacije kod čelika koji imaju različit sadržaj mikrolegirajućeg elementa niobija. ]]></summary_hr><summary_en><![CDATA[With the development of modern testing methods, today in the world researches are conducted on material flow and stress distribution in the deformation zone. Special attention is paid to study the beginning of plastic flow of materials, especially in elastoplastic area. It has been noted that in some low carbon steels and aluminium alloys, after reaching the proportionality limit, there is occurrence of Lüders bands. There are different interpretations of this phenomenon. In this project research will be carried out on low carbon steel and the same steel microalloyed with different contents of niobium. Research will be carried out on steels with same chemical composition but with different size and arrangement of niobium precipitates. By applying modern methods of visioplasticity, thermography, digital image correlation, scanning and transmission electron microscopy, the influence of niobium on beginning and the flow of plastic deformation will be investigated. Simultaneously with tensile tests, measurements with thermographic and optical camera will be carried out. The impact of various parameters (strain rate, deformation degree, content of microalloying element niobium, size and distribution of precipitates of niobium) on the elastic, elastoplastic and plastic behaviour of steel will be investigated, and same on the forming of deformation zone and stresses distribution in deformation zone. Special attention will be paid to the study of parameters affecting the formation and propagation of Lüders bands in elastoplastic area. It will be explored the impact of the initial structure, size and orientation of the grains on the occurrence and propagation of Lüders bands. In detail will be explored the structural changes that occur in the steel during the formation of Lüders bands and at different stages of its propagation through the deformation zone, at different strain rates of steels which have different content microalloying element niobium.]]></summary_en></project><project>
<id>4548</id><title_hr><![CDATA[Inovativni postupci uklanjanja AFM1 biofiksatorima iz mlijeka]]></title_hr><title_en><![CDATA[Innovative methods for the removal of AFM1 using biofixators from the milk]]></title_en><user_id>416</user_id><user_firstLast_name>Ksenija Markov</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2016-06</proposal_call><code>IP-2016-06-4306</code><acronim><![CDATA[BIOMYCOFIX-MILKFREE]]></acronim><duration>01.03.2017 - 28.02.2019</duration><status>Završio</status><financ_value>64.249,92 eur</financ_value><scie_area_hr>Biotehničke znanosti, Biomedicina i zdravstvo, Prirodne znanosti, </scie_area_hr><scie_area_en>Biotechnical sciences, Biomedicine and health sciences, Natural sciences, </scie_area_en><scie_field_hr>Biotehnologija, Kemija, Javno zdravstvo i zdravstvena zaštita, </scie_field_hr><scie_field_en>Biotechnology, Chemistry, Public health and health services, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prehrambeno-biotehnološki fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Food Technology and Biotechnology]]></institution_en><team_members_id>214, 19402, 19401, 19513, 19497, 19514, 19515, 19662, </team_members_id><team_members_names><![CDATA[Jadranka Frece, Željko  Jakopović, Iva Čanak, Jasna Bošnir, Željka Kuharić, Sonja Serdar, željka pavlek, Martina Ivešić, ]]></team_members_names><keywords_hr><![CDATA[AFM1, biofiksatori, bakterije mliječne kiseline, ß-glukan, inovativne metode uklanjanja AFM1, nutritivna vrijednost mlijeka]]></keywords_hr><keywords_en><![CDATA[AFM1, biofixators, lactic acid bacteria, ß-glucan, innovative methods of removing AFM1, nutritive value of milk]]></keywords_en><summary_hr><![CDATA[Praćenjem EU RASFF sustava žurnog uzbunjivanja primjećena je značajna prisutnost mikotoksina u hrani za ljude i životinje. S obzirom na toksičnost mikotoksina od iznimne je važnosti kontrolirati njihovu prisutnost i količinu u hrani. Nakon što je dokazano da kao produkt biološke pretvorbe aflatoksina B1 u mliječnim žlijezdama sisavaca hranjenih krmom koja je sadržavala spomenuti aflatoksin B skupine, nastaje aflatoksin M1, koji  je izoliran iz mlijeka i urina životinja, postoji zabrinutost oko ulaska mikotoksina u prehrambeni lanac čovjeka, ne samo kroz žitarice i proizvode od žitarica već i kroz meso, jaja, mlijeko i mliječne proizvode zbog faktora prijenosa („carry over” efekt). Međutim, važno je napomenuti da još uvijek nisu pronađene točne, pouzdane i učinkovite strategije uklanjanja prisutnih mikotoksina u hrani i/ili krmivu te se stoga istraživanja mogućnosti uklanjanja mikotoksina mikrobnim kulturama i njihovim staničnim komponentama nameću kao moguća alternativa postojećim fizikalnim i kemijskim metodama detoksifikacije. Cilj projekta je  istražiti primjenu bakterija mliječne kiseline (BMK) i ß- glukana i mogući način uklanjanja dobivenog kompleksa s mikotoksinom iz mlijeka. Kako bi se ispitao  utjecaj odabranih postupaka na kvalitetu mlijeka određivati će se i parametri kvalitete mlijeka: masti, bjelančevine, ugljikohidrati, laktoza. Cilj projekta  je i potaknuti proizvođače mlijeka  na kontinuirano praćenje AFM1 u mlijeku, budući da najveća odgovornost za kvalitetu i zdravstvenu ispravnost mlijeka leži na subjektima u poslovanju s hranom. Dobiveni rezultati pokazat će kako se primjenom BMK i  ß- glukana samostalno ili u kombinaciji može ukloniti AFM1  iz mlijeka ili svesti na propisane najveće dozvoljene količine (NDK). Nadalje rezultati ovog projekta biti će od značaja proizvođačima mlijeka i mliječnih proizvoda, te resornim ministarstvima, zbog njihove primjene u svrhu smanjenja gospodarskih šteta koje nastaju prilikom kontaminacije mlijeka AFM1.]]></summary_hr><summary_en><![CDATA[The EU RASFF system observed the significant presence of mycotoxins in food for humans and animals. Due to the toxicity of mycotoxins it is extremely important to control their presence and quantity in foods. After it was shown that the product of biological conversion of aflatoxin B1 in the mammary glands of mammals fed with feed containing said aflatoxin B group, aflatoxin M1 is formed, which is isolated from the milk and urine of animals, there are concerns about mycotoxins entering human food chain, not only through cereals and cereal products, but also through meat, eggs, milk and milk products if the animals were fed with feed contaminated with molds that synthesize mycotoxins, or with mycotoxins alone (carry over). It is important to note that accurate, reliable and efficient strategy for removal of present mycotoxins in food and feed have not yet been found, therefore research of opportunities for removing mycotoxins with microbial cultures and their cellular components are imposed as an alternative to existing physical and chemical methods of detoxification. The project aims to explore the application of lactic acid bacteria and ß-glucan and possible removal of resulting complex with a mycotoxin from the milk. In order to examine the impact of selected methods on milk quality, following parameters will be determined: fat, protein, carbohydrates, lactose. The project also aims to encourage milk producers to continuously monitor AFM1 in milk, since the greatest responsibility for the quality and safety of milk is the subjects dealing with food. The results will show how the application of LAB and ß-glucan alone or in combination can remove AFM1 from milk or reduce to a prescribed maximum permissible limit. Furthermore, the results of this project will be of great significance to the milk and dairy products producers as well as the relevant ministries, because of their application to reduce economic damages which results from the milk contamination with AFM1.]]></summary_en></project><project>
<id>4550</id><title_hr><![CDATA[Uloga unutarstaničnog života Francisella tularensis u patogenezi eksperimentalne tularemije]]></title_hr><title_en><![CDATA[The role of the intracellular life cycle of Francisella tularensis for the pathogenesis of experimental tularemia]]></title_en><user_id>114</user_id><user_firstLast_name>Marina Šantić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2016-06</proposal_call><code>IP-2016-06-9003</code><acronim><![CDATA[FRANCYCLE]]></acronim><duration>05.06.2017 - 04.11.2021</duration><status>Završio</status><financ_value>121.441,37 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, Kliničke medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, Clinical sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Medicine]]></institution_en><team_members_id>6961, 115, 12452, 117, 3102, 20006, 20145, 25206, 27882, </team_members_id><team_members_names><![CDATA[Maja Abram, Mateja Ožanič, Mirna Mihelčić, Valentina Marečić, Sanja Štifter, Jiri Stulik, Marek Link, Ina Kelava, Maša Knežević, ]]></team_members_names><keywords_hr><![CDATA[Francisella, FPO, sazrijavanje fagosoma/vakuole, autofagija, in vitro, in vivo]]></keywords_hr><keywords_en><![CDATA[Francisella, FPI, phagosome/vacuole maturation, autophagy, in vitro, in vivo]]></keywords_en><summary_hr><![CDATA[Francisella tularensis je gram-negativna, visoko infektivna, fakultativno unutarstanična bakterija koja uzrokuje tularemiju. Unutarstanični život F. tularensis je jedinstven u odnosu na druge unutarstanične bakterije. Fagosom koji sadrži francizelu (FCP - Francisella containing phagosome) zaustavljen je u fazi kasnog nezakiseljenog endosoma, nakon čega slijedi postupni bakterijski izlazak u citosol. Očito je da Francisella kruži kroz različite unutarstanične odjeljke; FCP i vakuolu koja sadrži francizelu (FCV – Franicisella containing vacuole). Zbog važnosti ovih staničnih odjeljaka u uspostavi i održavanju infekcije, po prvi put ćemo izolirati FCP i FCV iz makrofaga. Ovo je potpuno novi pristup u razumijevanju njihove uloge u unutarstaničnom životu francizela. Nadalje, pretpostavljamo da se značajni dio interakcije sa citosolom domaćina ostvaruje putem autofagije. Moguće je da, u kasnijoj fazi infekcije, Francisella oblikuje oštećenu FCV u autofagnu vakuolu. Brojna su istraživanja usredotočena na dio bakterijskog genoma poznatijem kao Francizela patogeni otok (FPO). Mnoge FPO mutante pokazuju jednoobrazan fenotip karakteriziran nemogućnošću bijega iz fagosoma, izostankom unutarstanične replikacije te gubitkom virulencije in vivo. Želimo dokazati da su FPO proteini (PdpC, IglC, IglI, PdpE i IglG) koji su efektori tipa VI sekrecijskog sustava uključeni u regulaciju procesa autofagije. Autofagija se smatra jednim od efektorskih mehanizama urođene imunosti protiv unutarstaničnih bakterija. Podaci o ulozi autofagije u regulaciji citokinske mreže tijekom tularemije su još uvijek rijetki i proturječni. Stoga bi naša daljnja istraživanja, posebno u modelu Atg5 transgeničnih miševa, trebala pridonijeti boljem razumijevanju autofagije kao imunom odgovoru na infekciju francizelom. Očekivani rezultati doprinijet će rasvjetljavanju patogeneze tularemije te pridonijeti razvoju novih terapijskih i preventivnih strategija baziranih na autofagiji.]]></summary_hr><summary_en><![CDATA[Francisella tularensis is a highly virulent facultative intracellular pathogen that causes  disease tularemia. The intracellular lifestyle of F. tularensis is unique compared to other intracellular pathogens. The Francisella-containing phagosome (FCP) is arrested at a non-acidified late endosome-like stage, which is followed by gradual bacterial escape into the cytosol. It is obvious that Francisella cycles through different intracellular compartments; FCP and the Francisella-containing vacuole (FCV). Because of the importance of these subcellular compartments during infection, we will establish a novel method of isolating the FCP/FCV from macrophages. This is an innovative approach in understanding their role in Francisella intracellular life cycle. Secondly, we proposed that the great part of communication with the host cytosol environment is accomplished by autophagy. We assume that Francisella reseal damaged FCV into the autophagic vacuole later during the infection. Many studies have been focused on a genomic region called the Francisella pathogenicity island (FPI). Some of the FPI mutants show a uniform phenotype characterized by lack of phagosomal escape, no intracellular replication, and a loss of virulence in vivo. We expect to find that FPI proteins, PdpC, IglC, IglI, PdpE, and IglG that are effectors of the type VI secretion system are also involved in manipulation of autophagy machinery. Autophagy is regarded as one of the innate immunity effectors against intracellular bacteria. However, the data on the role of autophagy in the regulation of cytokine networks by Francisella are still unknown. We propose a new concept using transgenic Atg5 mouse that should contribute to a better understanding of autophagy as host immune response to Francisella infections. The project will contribute to understanding the pathogenesis of tularemia, providing opportunities for the development of novel autophagy-based therapeutic and preventive strategies.]]></summary_en></project><project>
<id>4552</id><title_hr><![CDATA[Ekstrakcije bioaktivnih spojeva iz mediteranskog bilja sa “zelenim otapalima” primjenom visokonaponskog pražnjenja]]></title_hr><title_en><![CDATA[High voltage discharges for green solvent extraction of bioactive compounds from Mediterranean herbs]]></title_en><user_id>469</user_id><user_firstLast_name>Anet Režek Jambrak</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2016-06</proposal_call><code>IP-2016-06-1913</code><acronim><![CDATA[GREENVOLTEX]]></acronim><duration>01.03.2017 - 28.02.2021</duration><status>Završio</status><financ_value>132.225,10 eur</financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Prehrambena tehnologija, Poljoprivreda, Biotehnologija, </scie_field_hr><scie_field_en>Food technology, Agriculture, Biotechnology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prehrambeno-biotehnološki fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Food Technology and Biotechnology]]></institution_en><team_members_id>19322, 19306, 19304, 130, 403, 4728, 3170, 5722, 591, 6854, 20213, 20245, 21336, 25273, 24300, 2853, 1342, </team_members_id><team_members_names><![CDATA[Farid Chemat, Francisco Jose Barba, Francesco Donsi&amp;#39; Donsi&amp;#39;, Jasminka Giacometti, Tea  Bilušić, Greta Krešić , Mara Banović, Sanda Pleslić, Marija  Badanjak Sabolović, Nikolina Mrduljaš, Slaven Jurić, Marko Viskić, Igor Dubrović, Marinela Nutrizio, Predrag Putnik, Adela Krivohlavek, Irena Žuntar, ]]></team_members_names><keywords_hr><![CDATA[visokonaponsko pražnjenje, plazma, ekstrakcije, zelena otapala, mediteransko bilje]]></keywords_hr><keywords_en><![CDATA[high voltage discharges, plasma, extraction, green solvents, mediteranean herbs]]></keywords_en><summary_hr><![CDATA[Prehrambena industrija intenzivno razvija ne-toplinske tehnike obrade hrane kao što su netoplinske plazme, pulsirajuće električno polje, visoki hidrostatski tlak te ultrazvuk visokog intenziteta. Nove netoplinske tehnike omogućavaju provedbu ekstrakcije bioaktivnih tvari bez primjene organskih otapala pri čemu se kao otapalo može koristiti voda ili neka tzv. “zelena otapala” npr. voda, D-limonen, dimetilkarbonat (DMC), etanol, etil-acetat i dr. Jedna od takvih obećavajućih tehnika je i visokonaponsko električno pražnjenje-plazma. Projektom će se nastojati ostvariti sljedeći ciljevi:C1 Razviti uređaj za generiranje plazme koji se sastoji od generatora plazme i reaktora s različitim konfiguracijama elektroda pri čemu će se koristiti inovativan pristup generiranja visokog napona DC napajanja pomoću moderne solid state tehnologije. C2 Utvrditi će se učinkovitost ekstrakcije bioaktivnih komponenti i eteričnih ulja iz autohtonog mediteranskog bilja (list masline, ružmarin, kadulja, mravinac, timijan, majčina dušica) plazmom uz upotrebu vode i „zelenih„ otapala. C3 Optimizirati će se djelovanje inovativnog uređaja za generiranje plazme tijekom ekstrakcija kako bi dobili što veće iskorištenje postupka.C4 Utvrditi će se biološka aktivnost dobivenih ekstrakata putem analitičkih metoda, te ispitati mogućnost nastajanja eventualnih oksidativnih promjena tijekom postupaka ekstrakcija. C5  Dobiveni ekstrakti će se na odgovarajući način izolirati te stabilizirati primjenom postupaka liofilizacije i/ili inkapsulacije.Predloženo istraživanje doprinijeti će području istraživanja, na način da će biti konstruiran inovativni uređaj za produkciju plazme direktno u tekućinama kojim će se moći provesti brza i učinkovita ekstrakcija bioaktivnih komponenata i eteričnog ulja iz autohtonog mediteranskog bilja. Novom netoplinskom tehnikom ekstrakcije nastojat će se smanjiti vrijeme ekstrakcije, upotreba otapala, onečišćenje okoliša i ukupan energetski utrošak uz istovjetno iskorištenje.]]></summary_hr><summary_en><![CDATA[The food industry is rapidly developing new non-thermal food processing techniques like non-thermal plasma, pulsed electric field, high hydrostatic pressure and high intensity ultrasound. New non-thermal techniques are considered “green” extraction methods for isolation of bioactive compounds, because conventionally used organic solvents for extraction can be replaced by water or other green solvents like D-limonen, dimethylcarbonate (DMC), ethanol, ethyl-acetate etc. High voltage electrical discharge-plasma (HVED) is one of new promising green techniques. The aims of this project will be accomplished and they include:O1 Design and development an equipment for generating plasma which consists of: plasma generator and reactor with different configuration of electrodes. During designing of plasma generator, new innovative approach for generating high voltage DC supply by usage of modern solid state technology will be applied.O2 To established effectiveness of extraction of bioactive compounds and volatile oils from autochthonous Mediterranean herbs (olive leaf, rosemary, sage, oregano, thyme, wild thyme), with plasma by usage of water and green solvents O3 To increase yield of process by optimisation of the operation mode of innovative equipment for generating plasma.O4 Biological activity of obtained extracts will be determined by analytical methods, and investigated the possibility of oxidative changes during extraction processO5 Obtained extracts will be isolated and stabilized by lyophilization and/or encapsulation. This Project proposal will contribute to the research area by constructing a new innovative equipment for liquid plasma which will be useful for quick and efficient extraction of bioactive compounds and volatile oils from leaves of autochthonous Mediterranean herbs. By new, non-thermal extraction technique, the attempt is to reduce duration of extraction, solvent usage, environment pollution and total energy consumption.]]></summary_en></project><project>
<id>4554</id><title_hr><![CDATA[Uporaba podataka daljinskih istraživanja dobivenih različitim 3D optičkim izvorima u izmjeri šuma]]></title_hr><title_en><![CDATA[Retrieval of Information from Different Optical 3D Remote Sensing Sources for Use in Forest Inventory]]></title_en><user_id>1275</user_id><user_firstLast_name>Ivan  Balenović</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2016-06</proposal_call><code>IP-2016-06-7686</code><acronim><![CDATA[3D-FORINVENT]]></acronim><duration>01.03.2017 - 28.02.2021</duration><status>Završio</status><financ_value>96.622,20 eur</financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Šumarstvo, </scie_field_hr><scie_field_en>Forestry, </scie_field_en><institution_hr><![CDATA[Hrvatski šumarski institut]]></institution_hr><institution_en><![CDATA[Croatian Forest Research Institute]]></institution_en><team_members_id>19806, 20222, 819, 24108, 24045, 24107, </team_members_id><team_members_names><![CDATA[Anita  Simic Milas, Ante Seletković, Maša Zorana Ostrogović Sever, Danijela Ivanković, Goran Tijan, Luka Jurjević, ]]></team_members_names><keywords_hr><![CDATA[izmjera šuma, uređivanje šuma, daljinska istraživanja, digitalna fotogrametrija, GIS]]></keywords_hr><keywords_en><![CDATA[forest mensuration, forest management, remote sensing, digital photogrammetry, GIS]]></keywords_en><summary_hr><![CDATA[Šuma je najrašireniji kopneni ekosustav na Zemlji te pruža mnogo direktnih i indirektnih dobrobiti ljudskom čovječanstvu. Potrajno gospodarenje šumama uz osiguranje njenih mnogobrojnih funkcija i usluga zahtjeva prostorno određene  informacije o stanju i razvoju šume koje se uglavnom prikupljaju u okviru inventure šuma. Prikupljanje podataka o šumama na tradicionalni način, terenskom izmjerom, pruža točne informacije, ali zahtijeva dugotrajan i intenzivan rad, a u pojedinim slučajevima pristup određenim šumskim područjima je otežan ili čak nemoguć. Upravo iz tog razloga prepoznat je potencijal upotrebe metoda daljinskog istraživanja (DI) pri inventuri šuma. Unatoč dostupnosti različitih podataka DI i velikom potencijalom za njihovo korištenje pri izmjeri šuma, u Hrvatskoj, kao i u mnogim drugim zemljama, izmjera šuma se još uvijek temelji samo na tradicionalnoj terenskoj izmjeri.Stoga je glavni cilj predloženog projekta razviti i testirati metode temeljene na različitim 3D optičkim podacima DI za primjenu u inventuri šuma, a u svrhu poboljšanja učinkovitosti i ekonomičnosti postojećih terenskih načina prikupljanja podataka. Konkretno, ispitati će se točnost proizvoda (oblak točaka, DMVK, ortofoto) izvedenih iz različitih 3D podataka DI (aerosnimke, satelitske snimke, snimke bespilotne letjelice) i različitih prostornih rezolucija, za procjenu varijabli pojedinačnih stabala i šumskih sastojina na raznim prostornim razinama. Istražiti će se i mogućnost njihove primjene u automatskoj segmentaciji i klasifikaciji pojedinačnih stabala i šumskih sastojina. Općenito, a posebice u zemljama jugoistočne Europe, nedostaju komparativne studije koje se bave usporedbom podataka o šumama dobivenih iz različitih 3D optičkih senzora DI. Ovo istraživanje će dati prve informacije o kvaliteti i točnosti navedenih podataka i njihovih produkata te mogućnosti njihove primjene u inventuri šuma. Stoga, će dobiveni rezultati biti od iznimnog značaja i interesa za šumarsku znanost i praksu.]]></summary_hr><summary_en><![CDATA[As the most widely distributed terrestrial ecosystem on the earth, forests provide many direct and indirect benefits to human well-being. Sustainable management of forests’ multiple functions and services requires spatially explicit information about forests state and development, which are usually acquired through forest inventories.Although traditional field-based forest inventory can provide relatively accurate information, the process is time-consuming and labour intensive, and in some cases access to certain forest areas is not possible. Therefore, the potential of remote sensing (RS) application in forest inventory have been long recognized by both researchers and practicing foresters. Despite the availability of various RS data and great potential for their use, in Croatia as well as in many other countries, forest inventory is still based only on traditional field methods.Therefore, the main goal of this proposal is to develop and evaluate methods and workflows for forest inventory applications based on different 3D RS data, aiming to improve efficiency and cost-effectiveness of current field-based inventory practices. Specifically, the accuracy of products (image-based point cloud, CHM, orthoimage) derived from various 3D RS data (UAS, airborne, satellite stereo images) with different spatial resolutions will be evaluated for estimating the main tree and forest stand attributes at various spatial levels. Secondly, automatic segmentation and classification of both individual trees and forest stands using above mentioned products will be investigated. A comparison studies dealing with performance of different 3D RS data in forest inventory are lacking, especially in the South-east European region. Therefore, this research will provide first assessments of quality and accuracy of forest information derived from different 3D RS data and its products. Thus, the results of this research will be of interests for both forestry researchers and industry.]]></summary_en></project><project>
<id>4555</id><title_hr><![CDATA[Primjena visokog hidrostatskog tlaka u proizvodnji funkcionalnih sokova na bazi voća i povrća]]></title_hr><title_en><![CDATA[High Hydrostatic Pressure Processing of Functional Fruit and Vegetable Juices ]]></title_en><user_id>2657</user_id><user_firstLast_name>Damir Ježek</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2016-06</proposal_call><code>IP-2016-06-4006</code><acronim><![CDATA[HIGHPRESS-JUICE]]></acronim><duration>01.03.2017 - 31.05.2021</duration><status>Završio</status><financ_value>132.590,09 eur</financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Prehrambena tehnologija, </scie_field_hr><scie_field_en>Food technology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prehrambeno-biotehnološki fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Food Technology and Biotechnology]]></institution_en><team_members_id>20146, 2663, 13352, 19401, 214, 1243, 1056, 20151, 7761, </team_members_id><team_members_names><![CDATA[Marko Marelja, Sven Karlović, Tomislav Bosiljkov, Iva Čanak, Jadranka Frece, Verica Dragović-Uzelac, Zoran Zorić, Marko Škegro, Nada Vahčić, ]]></team_members_names><keywords_hr><![CDATA[visoki hidrostatski tlak, funkcionalni sokovi, inaktivacija mikroorganizama, organoleptička analiza, bioaktivne tvari, voće, povrće]]></keywords_hr><keywords_en><![CDATA[high hydrostatic pressure, functional juices, inactivation of microorganisms, sensory analysis, bioactive compounds, fruit, vegetables]]></keywords_en><summary_hr><![CDATA[Svježi sokovi te smoothie od voća i povrća se mogu smatrati funkcionalnim proizvodima s visokim udjelom bioaktivnih spojeva kojima se pripisuju pozitivni učinci na zdravlje. Kako bi se sačuvali bioaktivni spojevi, poželjna senzorska svojstva te mikrobiološka stabilnost tijekom skladištenja, konzerviranje ovih proizvoda vrši se primjenom novih tehnika poput visokog hidrostatskog tlaka (VHT). Stoga je cilj ovog projekta istražiti biološki potencijal različitih vrsta voća i povrća (obzirom na zastupljenost bioaktivnih spojeva-karotenoida, klorofila, antocijana, polifenola), s krajnjim ciljem formuliranja voćnih ili povrtnih sokova i smoothija koji će sadržavati visok i izbalansiran udio bioaktivnih spojeva, dobrih senzorskih svojstava te veće stabilnosti tijekom skladištenja. Sokovi će se proizvoditi hladnim prešanjem nakon čega će se dio podrvgnuti pasterizaciji, a dio će se tretirati VHT. Određivat će se utjecaj VHT na učinkovitost postupka homogenizacije te disperziju čestica pulpe u obrađenim uzorcima. Za svaku vrstu proizvoda će se definirati optimalni uvjeti pri kojima se postižu najbolja nutritivna, biološka i  senzorska svojstva te mikrobiološka stabilnost. Provedena istraživanja predstavljaju dobru bazu za razvijanje  novih funkcionalnih proizvoda na bazi voća i povrća u kojima bi bili sadržani ciljani bioaktivni spojevi iz različitih skupina, koji bi zahvaljujući kombiniranom i sinergijskom djelovanju osigurali izrazita biološka te poželjna senzorska svojstva.]]></summary_hr><summary_en><![CDATA[Fresh juices and smoothies based on fruit and vegetables are considered to be functional products with a high amount of bioactive compounds, which have a positive influence on health. To preserve bioactive compounds, sensory properties, and microbiological stability during storage, preservation of those products is performed using new non-thermal technologies such as high hydrostatic pressure (HHP). In that regard main goal of this project is to investigate the biological potential of different fruits and vegetables (based on the proportion of bioactive compounds – carotenoids, chlorophylls, anthocyanins, polyphenols), with the end goal to formulate recipes and process parameters for fruit or vegetable juices and smoothies. Those products will contain a high and balanced share of bioactive compounds, have excellent sensory properties and longer shelf life. Juices will be produced using cold press technique, and afterwards processed using conventional pasteurisation or high hydrostatic pressure. Influence of HHP process parameters on the homogenization and particle dispersion in samples will be determined. For every type of product, optimal HHP processing conditions will be determined, to ensure best nutritive, biological and sensory properties, as well as microbiological stability. Conducted research is a solid base for development of new functional fruit and vegetable based products, which would contain targeted bioactive compounds from different groups. Those compounds will have combined and synergistic effect and ensure exceptional biological and sensory properties.]]></summary_en></project><project>
<id>4557</id><title_hr><![CDATA[Istraživanje ravnoteže mikrobioma debelog crijeva]]></title_hr><title_en><![CDATA[Exploring Gut Microbiome Equilibrium]]></title_en><user_id>5774</user_id><user_firstLast_name>Antonio Starčević</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2016-06</proposal_call><code>IP-2016-06-3509</code><acronim><![CDATA[MicroEquilibrium]]></acronim><duration>02.05.2017 - 01.07.2021</duration><status>Završio</status><financ_value>126.352,11 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo, Biotehničke znanosti, Prirodne znanosti, Tehničke znanosti, Društvene znanosti, </scie_area_hr><scie_area_en>Biomedicine and health sciences, Biotechnical sciences, Natural sciences, Technological sciences, Social sciences, </scie_area_en><scie_field_hr>Biotehnologija u biomedicini, Matematika, Biologija, Računarstvo, Kliničke medicinske znanosti, Biotehnologija, Prehrambena tehnologija, Nutricionizam, </scie_field_hr><scie_field_en>Biotechnology in Biomedicine, Mathematics, Biology, Computer sciences, Clinical sciences, Biotechnology, Food technology, Nutrition, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prehrambeno-biotehnološki fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Food Technology and Biotechnology]]></institution_en><team_members_id>19799, 20165, 7639, 4282, 799, 798, 18967, 20256, 517, 1040, 110, 3536, 28256, 28774, </team_members_id><team_members_names><![CDATA[Dina Rešetar, Ivona Višekruna, Marcel Lipej, Ivana Banić, Jagoda Šušković, Blaženka Kos, Martina Marijanović, Ena Melvan, Damir  Oros, Miran Čoklo, Jurica Žučko, Mario Cindrić, Jasenka Škrlin, Ema Svetličić, ]]></team_members_names><keywords_hr><![CDATA[mikrobiom, bioreaktor, mikrobiota, ravnoteža, probiotik, prebiotik, pretilost, fekalni transplant, personalizacija, enterotip]]></keywords_hr><keywords_en><![CDATA[microbiome, bioreactor, microbiota, equilibrium, probiotic, prebiotic, obesity, fecal transplant, personalization, enterotype]]></keywords_en><summary_hr><![CDATA[MicroEquilibrium želi in vitro, u bioreaktoru uspostaviti i održavati dinamičku ravnotežu mikroorganizama definiranu  postojanjem pozitivne kovarijance između udjela rodova Bacteroides, Prevotella i Ruminococcus u inokulumu (fecesu) i biomasi izuzetoj nakon provedenog šaržnog uzgoja s prihranom u bioreaktoru. U tako uspostavljenom modelu ispitivati će se utjecaj niza kombinacija prebiotika i pro-lijekova na promjenu ravnoteže sa ciljem pomaka prema enterotipu karakterističnom za fenotip zdravstveno poželjnog BMI-a. Jedino interdisciplinarnim pristupom koji uključuje sistemsku biologiju,genomiku, proteomiku,bioinformatiku,kliničku medicinu,antropologiju,matematičko modeliranje i društveni izazov pretilosti moguće je istraživati problematiku kompleksnih mikrobnih zajednica našeg probavila. Prednost ovakvog pristupa jest u činjenici da se istraživanjem in vitro, može efikasno eliminirati niz čimbenika i etičkih pitanja nad kojima inače nemamo kontrolu. Potencijal rezultata koje ovo istraživanje može generirati jest u mogućnosti personalizacije terapeutika baziranih na standardiziranim i neškodljivim dodacima prehrani u vidu prebiotika i pro-lijekova gdje je efikasnost ispitana u uvjetima in vitro. Uvođenje testiranja učinkovitosti in vitro, u bioreaktoru iznad je trenutnog stanja tehnike kada su u pitanju pretilost i dodaci prehrani gdje se sve više dovodi u pitanje njihova učinkovitost pri jednoobraznoj primjeni. Odjek ovakvog interdisciplinarnog istraživanja odnosi se na društvo u cjelosti. Pretilost je postala globalni problem,a niti jedna zemlja u posljednjih 33 godine nije uspjela preokrenuti ovaj negativni trend koji uzima veliki danak kroz sve veće izdatke u javnom zdravstvu. Istraživanje dinamike ravnoteže crijevnog mikrobioma s ciljem usmjeravanja prema željenom ishodu jedan je od najperspektivnijih smjerova u koji treba uložiti istraživačke napore da se pronađu odgovarajuća rješenja kako bismo ponudili što efikasniju terapiju ovom globalnom problemu.]]></summary_hr><summary_en><![CDATA[MicroEquilibrium aims to establish and maintain dynamic equilibrium of gut microbiota in vitro. Equilibrium is defined by positive covariance between ratios of Bacteroides, Prevotella and Ruminococcus observed in donor feces and in extracted biomass after fed-batch bioreactor cultivation. This in vitro model will be utilized to test hypothesis where introducing combinations of prebiotics and ortho-silicic acid in form of zeolites during cultivation can shift the observed equilibrium in targeted direction. Targeted direction is positively correlated with genus ratios observed in volunteers having healthy BMI span. Only an interdisciplinary approach which includes system biology,genomics,proteomics, bioinformatics,medicine,anthropology and mathematcial modelling can provide us with insights into dynamics of complex microbial communities existing in our guts. Using bioreactor model instead of volunteers is an attractive possibility which removes obstacles such as lack of control and ethical issues. Greatest benefit of planned research is the possibility to translate  results into personalized therapy for obesity which targets host mibrobiota equilibrium. The fact that the efficacy of this therapy is already tested in vitro is one step above current state-of-the-art in the field. Impact of this interdisciplinary research is great since it targets a major social, medical and economical problem. Obesity is one of the leading global problems. In the last 33 years not a single country has managed to turn this negative trend which is taking it&#39;s toll in terms of growing healthcare expenses. Since current research is questioning efficacy of generic treatment of systemic conditions such as obesity with drugs and probiotics, defining and exploring the dynamic equilibrium of microbiota is a perspective research direction. This direction requires a lot if effort and this project lowers threshold by going in vitro.]]></summary_en></project><project>
<id>4558</id><title_hr><![CDATA[Problemi u ponašanju djece školske dobi: Uloga izvršnih funkcija, individualnih, obiteljskih i genetskih čimbenika]]></title_hr><title_en><![CDATA[Problem behaviours in elementary school-aged children: The role of Executive funCtioning, individuL, familiAl, and geneTic factors ]]></title_en><user_id>2967</user_id><user_firstLast_name>Silvija Ručević</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2016-06</proposal_call><code>IP-2016-06-3917</code><acronim><![CDATA[ECLAT]]></acronim><duration>10.01.2017 - 09.06.2021</duration><status>Završio</status><financ_value>46.006,37 eur</financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Psihologija, </scie_field_hr><scie_field_en>Psychology, </scie_field_en><institution_hr><![CDATA[Sveučilište Josipa Jurja Strossmayera u Osijeku, Filozofski fakultet]]></institution_hr><institution_en><![CDATA[Josip Juraj Strossmayer University of Osijek, Faculty of Humanities and Social Sciences]]></institution_en><team_members_id>2501, 2737, 20109, 12480, </team_members_id><team_members_names><![CDATA[Dino Krupić, Jasenka Wagner, Sandra Vučković, Tijana Borovac, ]]></team_members_names><keywords_hr><![CDATA[izvršne funkcije, MAOA, psihopatske tendencije, roditeljski postupci, rana iskustva, problemi u ponašanju, rizična ponašanja, longitudinalno]]></keywords_hr><keywords_en><![CDATA[executive functions, MAOA, psychopathic tendencies, parenting practecies, early experiences, problem behaviors, risky behaviors, longitudinal]]></keywords_en><summary_hr><![CDATA[Cilj istraživanja je ispitati učinke različitih čimbenika rizika iz različitih domena u razvoju problema u ponašanju djece osnovnoškolske dobi koristeći longitudinalni nacrt istraživanja. Ovo istraživanje se temelji na podacima slučajno odabranih 165 parova djece i roditelja iz 15 vrtića iz urbanog središta u Istočnoj Hrvatskoj. Podaci su prikupljeni u dvije točke mjerenja, s godinom dana razmaka (Pilot studija). Konkretno, prvi val (T1) Pilot studije proveden je između svibnja 2015. i veljače 2016. godine. Drugi val (T2) se trenutačno provodi. Djeca uključena u Pilot studiju su iz dvije dobne kohorte, (svibanj-prosinac) 2009. i (siječanj-svibanj) 2010, a oko polovice njih su dječaci (51%). Pilot studija će se koristiti kao prva dva vala sadašnjeg istraživanja.Sadašnje istraživanje imat će tri dodatna vala prikupljanja podataka, odnosno T3, T4 i T5. S obzirom na raspored istraživanja u Pilot studiji, T3, T4 i T5 bi trebali početi u svibnju 2017, svibnju 2018. i svibnju 2019. godine. U odnosu na Pilot istraživanje, sadašnje istraživanje će ispitati i učinke genetskih čimbenika (tj. MAOA) na probleme u ponašanju kod djece. Kako bismo postigli ovaj cilj radit ćemo u multidisciplinarnom timu (tri psihologa, pedagog i specijalist za genetiku).Koristeći se snagama longitudinalnog istraživanja, sadašnje istraživanje će ispitati učinke rizičnih/zaštitnih čimbenika na kasniji razvoj djeteta. Konkretno, ciljevi istraživanja su ispitati: (1) nezavisni doprinos i moderatorske/medijacijske učinke izvršnih funkcija, individualnih obilježja, roditeljskih postupaka, ranih iskustava, te genetskih čimbenika na objašnjenje problema u ponašanju djece školske dobi; (2) kratkoročnu i dugoročnu korisnost ispitivanih varijabli za predviđanje budućih socijalnih i ponašajnih ishoda kod djece, te (3) heterotipski kontinuitet ispitivanih varijabli tijekom prijelaza iz predškolske (Pilot studija) u školsku dob (sadašnje istraživanje), uzimajući u obzir homotipski kontinuitet.]]></summary_hr><summary_en><![CDATA[The aim of the study is to examine the effects of risk factors form multiple domains on problem behaviours in elementary school-aged children using a longitudinal research design. This study is based on the data collected from randomly selected 165 parent-child dyads from 15 kindergartens in a large urban area of eastern Croatia, in two successive assessments, one year apart (Baseline study). Specifically, the first wave (T1) of the Baseline study was conducted between May 2015-February 2016. The second wave (T2) is currently underway. Children included in the Baseline study are from two birth cohorts, (May-December) 2009 and (January-May) 2010, and about half of them are males (51%). The Baseline study will be used as two first waves of the Present study.The Present study will include three additional study waves, namely T3, T4 and T5. Based on the time table from the Baseline study, the T3, T4 and T4 should commence in May 2017, May 2018, and May 2019, respectively. Relative to the Baseline study, the present study will examine the effects of genetic factors (i.e., MAOA) on problem behaviours in children. To achieve this objective, we will have multidisciplinary team (three psychologists,specialist in development,specialist in genetics). Using the strengths of the longitudinal design, the Present study will investigate the effects of risk/protective factors on the later development of children. Specifically, the study will examine (1) independent contributions and moderating/mediating effects of executive functions, individual characteristics, parenting, early experiences, and genetic factors on problem behaviours in elementary school-aged children; (2) short and long-term utility of examined variables for predicting future social and behavioural outcomes in children; and (3) heterotypic continuity of examined variables during the transition from preschool (the Baseline study) to elementary school age (the Present study), taking into account homotypic continuity. ]]></summary_en></project><project>
<id>4559</id><title_hr><![CDATA[Od nusproizvoda u preradi žitarica i uljarica do funkcionalne hrane primjenom inovativnih procesa]]></title_hr><title_en><![CDATA[From Grain Byproducts to Functional Food through Innovative Processing]]></title_en><user_id>7661</user_id><user_firstLast_name>Duška Ćurić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2016-06</proposal_call><code>IP-2016-06-3789</code><acronim><![CDATA[GbP-FFood]]></acronim><duration>01.03.2017 - 29.02.2020</duration><status>Završio</status><financ_value>99.542,11 eur</financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Prehrambena tehnologija, Nutricionizam, </scie_field_hr><scie_field_en>Food technology, Nutrition, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prehrambeno-biotehnološki fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Food Technology and Biotechnology]]></institution_en><team_members_id>19413, 19368, 13472, 13471, 12848, 19135, 19812, 13470, 19412, 6236, 20179, 11173, 25159, 25326, 26629, </team_members_id><team_members_names><![CDATA[Nikolina Čukelj, Dubravka Novotni, Dubravka Škevin, Klara Kraljic, Sandra Balbino, Saša Ajredini, Dražen Lušić, Marko Obranović, Bojana Voučko, Maja Benković, Marina Krpan, Mirjana Hruškar, Lidija Drobac, Matea  Habuš, Kristina Radoš, ]]></team_members_names><keywords_hr><![CDATA[nusproizvodi žitarica i uljarica, mikronizacija, ultrazvuk visokog intenziteta, enzimska hidroliza, nutritivni profil, funkcionalna hrana]]></keywords_hr><keywords_en><![CDATA[cereal and oilseed byproducts, micronization, high intensity ultrasound, enzimatic hydrolysis, nutritive profile, functional food]]></keywords_en><summary_hr><![CDATA[Suvremena prehrana je često nutritivno siromašna, a energetski bogata, što uzrokuje razne kronične bolesti. Unatoč tome, konvencionalna prerada biljnih kultura uobičajeno rezultira značajnom količinom nutritivno vrijednih nusproizvoda, kao što su posije žitarica i pogače uljarica, koje se uglavnom koriste kao stočna hrana. Primjenom spomenutih nusproizvoda u ljudskoj prehrani mogao bi se povećati unos vlakana, visokovrijednih proteina, esencijalnih masnih kiselina, mineralnih tvari, vitamina te raznih bioaktivnih spojeva koji mogu doprinijeti zdravlju. Jedan od razloga njihovog nedovoljnog iskorištenja u prehrani ljudi je slab interes potrošača, kao i narušena kvaliteta i trajnost prehrambenih proizvoda u koje se dodaju. Dodatno, upitna je i biološka iskoristivost navedenih nutrijenata, budući da se bioaktivni spojevi i mineralne tvari nalaze vezani u kompleksnim polimernim matriksima, a vlakna su većinom netopljiva.   Zbog svega navedenog se u okviru ovog projekta želi istražiti mogućnost maksimalnog iskorištenja makro- i mikronutrijenata te bioaktivnih sastojaka iz nusproizvoda mljevenja žitarica i proizvodnje ulja, uz osiguranje kvalitete krajnijih proizvoda. U tu svrhu provelo bi se fino usitnjavanje (10-30 µm) posija žitarica (pšenice, ječma, prosa i heljde) i pogača uljarica (buče, uljane repice, lana i sikavice) pri niskim temperaturama, obrada ultrazvukom visokog intenziteta te prirodna fermentacija sa ili bez dodatka enzima. Kombinacijom ovih tretmana očekuje se povećanje udjela slobodnih bioaktivnih spojeva te probavljivosti makro- i mikronutrijenata čime bi se moglo pospješiti njihovo djelovanje in vivo. Krajnji cilj projekta je optimizacija netoplinskih procesa obrade nusproizvoda žitarica i uljarica za dobivanje stabilnog i prehrambeno vrijednog materijala koji bi bio primjenjiv za obogaćivanje pekarskih i brašneno-konditorskih proizvoda i proizvoda namijenjenih osobama s posebnim prehrambenim potrebama.]]></summary_hr><summary_en><![CDATA[Modern diet is often based on nutritionally poor foods rich in energy, thus leading to different chronic diseases. Despite, conventional processing of plant foods results in significant amount of byproducts such as cereal bran and oilseed cakes, which are often used as an animal feed. Utilization of mentioned byproducts could result in increased daily intake of fibres, valuable proteins, essential fatty acids, minerals, vitamins, and different bioactive compounds, which can contribute to the human health. One reason of the insufficient utilization is low consumers interest, as well as impaired quality and shelf life of food products with added byproducts. Additionally, bioavailability of byproducts constituents is questionable, since bioactive compounds and minerals are mostly found in bound form in a complex polymer matrix, while fibres are mostly insoluble.  Thus, the aim of this project is the highest possible utilization of macro- and micronutrients and bioactive compounds from byproducts of industrial grain processing, together with preservation of the final products quality. For that reason, outer layers of cereal grains (wheat, barley, millet and buckwheat) and oilseed cakes (pumpkin seed, rapeseed, flax seed and milk thistle) will be milled to superfine particle size (10 – 30 µm), treated with high intensity ultrasound and spontaneously fermented with or without enzyme addition. The expected outcome of combined treatments is an increase of free bioactive compounds and digestibility of macro- and micronutrients, which could lead to their increased in vivo activity. Final goal of the project is optimisation of nonthermal processing of grain byproducts in order to obtain stable and nutritionally valuable material which can be used for enrichment of bakery and cereal based confectionary products and food for special dietary needs.   ]]></summary_en></project><project>
<id>4560</id><title_hr><![CDATA[Blaga repetitivna traumatska ozljeda mozga: model za istraživanje neuropatologije i neuroupale posredovane s TDP-43]]></title_hr><title_en><![CDATA[Mild repetitive traumatic brain injury: a model-system to study TDP-43-mediated neuropathology and neuroinflammation]]></title_en><user_id>20264</user_id><user_firstLast_name>Gordana Župan</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2016-06</proposal_call><code>IP-2016-06-4602</code><acronim><![CDATA[TDP-43repTBI]]></acronim><duration>01.06.2017 - 31.08.2021</duration><status>Završio</status><financ_value>129.072,93 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Medicine]]></institution_en><team_members_id>19186, 20286, 19750, 19848, 19752, 20292, 17173, 25435, </team_members_id><team_members_names><![CDATA[Kristina Pilipovic, Jasna Križ, Jelena Rajič, Tamara Janković, Petra Dolenec, Željko Župan, Jasenka Mršić-Pelčić, Nika Gržeta, ]]></team_members_names><keywords_hr><![CDATA[amiotrofična lateralna skleroza, frontotemporalna lobarna degeneracija, upala, repetitivna blaga traumatska ozljeda mozga, TDP-43, transgenični miš]]></keywords_hr><keywords_en><![CDATA[amyotrophic lateral sclerosis, frontotemporal lobar degeneration, inflammation, repetitive mild traumatic brain injury, TDP-43, transgenic mouse]]></keywords_en><summary_hr><![CDATA[Repetitivna blaga traumatska ozljeda mozga (engl. mild traumatic brain injury, mTBI) mogla bi biti povezana s proteinopatijom Tar DNA-vezujućeg proteina 43 (TDP-43) te klinički s razvojem kronične encefalopatije. Novija istraživanja ukazuju na prisutnost poremećaja u regulaciji TDP-43 u frontotemporalnoj lobarnoj degeneraciji (FTLD), amiotrofičnoj lateralnoj sklerozi (ALS) te drugim neurodegenerativnim poremećajima. Iako se repetitivna mTBI već dugo smatra čimbenikom rizika za pojavu demencija i ALS-a, patološka podloga još uvijek nije jasna. Prema novijim podatcima te našim preliminarni rezultatima, naša je hipoteza da repetitivna mTBI uzrokuje citosolno povećanje i agregaciju TDP-43 u središnjem živčanom sustavu (SŽS), što bi moglo biti uključeno u modulaciju dugotrajnog upalnog odgovora te posljedičnu neurodegeneraciju, a time i predispoziciju SŽS-a za razvoj FTLD/ALS. U ovom projektu koristit će se klinički relevantan model repetitivne mTBI. Radit će se testovi ponašanja, biokemijske i histološke metode, in vivo imaging te inovativne, stanično specifične, proteomske analize. Predloženi su sljedeći specifični ciljevi:1. Istražiti u kojoj je mjeri repetitivna mTBI povezana s disregulacijom TDP-43, neuroinflamacijom, neurodegeneracijom te razvojem TDP-43 posredovanih FTLD/ALS fenotipova u WT i TDP-43 transgeničnih miševa.2. Razviti sustav za in vivo imaging, koji će služiti za analize neuroinflamatornog odgovora izazvanog repetitivnom mTBI, u mišjem modelu, u realnom vremenu.3. Istražiti stanično-specifične molekularne karakteristike mikroglije nakon repetitivne mTBI u WT i TDP-43 transgeničnih miševa.Očekujemo da će rezultati ovog projekta omogućiti bolje razumijevanje patoloških promjena posredovanih TDP-43 i neuroinflamacijom u SŽS-u. Dodatno, jednom okarakteriziran mišji model za in vivo vizualizaciju mikroglioze u TBI/FTLD/ALS, bit će jedinstveno oruđe za analizu patologije te traženje meta za učinkovitu farmakoterapiju ovih bolesti.]]></summary_hr><summary_en><![CDATA[Repetitive mild traumatic brain injury (mTBI) may be associated with Tar DNA binding protein 43 (TDP-43) proteinopathy, and clinically with the development of chronic encephalopathy. Recent evidence suggests that TDP-43 disregulation has been identified also in frontotemporal lobar degeneration (FTLD), amyotrophic lateral sclerosis (ALS) and other neurodegenerative disorders. While repetitive mTBI has long been recognized as a risk factor for dementias and ALS, the underlying pathological mechanisms remain unclear. Based on some recent published evidence and our preliminary results, we hypothesize that repetitive mTBI induces cytosolic up-regulation/aggregation of TDP-43 in the CNS that may be involved in modulation of the long-lasting inflammatory response and consequent neurodegeneration thus predisposing CNS to develop FTLD/ALS. The clinically relevant model of repetitive mTB will be used. Behavioral, biochemical and histological methods, live imaging technique as well as innovative cell-type specific proteomic analyses will be performed. The following specific goals have been proposed: 1. To investigate to what extent the repetitive mTBI is associated with the deregulation of TDP-43, neuroinflammation, neurodegeneration and development of TDP-43 mediated FTLD/ALS phenotypes in WT mice and in the TDP-43 transgenic mice. 2. To develop in vivo model systems for real-time analysis of the repetitive mTBI-induced neuroinflammatory responses in biophotonic mouse model.  3. To investigate the microglial cells-specific molecular signatures after repetitive mTBI in WT and TDP-43 transgenic mice.   We expect that the results of this project will lead to better understanding of the TDP-43 and neuroinflammation mediated CNS pathology. Moreover, once characterized, the mouse model for live imaging of microgliosis in TBI/FTLD/ALS will represent unique tool for analysis of their in vivo pathology and efficient targeted drug screening. ]]></summary_en></project><project>
<id>4562</id><title_hr><![CDATA[Podrijetlo, ponašanje i modeliranje transporta nitrata u varaždinskom aluvijalnom vodonosniku]]></title_hr><title_en><![CDATA[Origin, fate and transport modelling of nitrate in the Varaždin alluvial aquifer]]></title_en><user_id>5844</user_id><user_firstLast_name>Tamara Marković</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2016-06</proposal_call><code>IP-2016-06-5365</code><acronim><![CDATA[TRANITAL]]></acronim><duration>01.03.2017 - 28.02.2021</duration><status>Završio</status><financ_value>109.945,19 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Geologija, Kemija, Biologija, </scie_field_hr><scie_field_en>Geology, Chemistry, Biology, </scie_field_en><institution_hr><![CDATA[Hrvatski geološki institut]]></institution_hr><institution_en><![CDATA[Croatian Geological Survey]]></institution_en><team_members_id>5602, 3694, 19512, 19403, 19671, 19717, 19727, 19777, 6065, 23443, 25213, </team_members_id><team_members_names><![CDATA[Ozren Larva, Željka Brkić, Jasmina Martinčević Lazar, Marija Gligora Udovič, Renato Buljan, KREŠIMIR MALDINI, SIMANA MILOVIĆ, Marija Vrsalović, Martina Šparica Miko, Antonija Kulaš, Igor Karlović, ]]></team_members_names><keywords_hr><![CDATA[nitrat, kakvoća podzemne vode, stabilni izotopi, model transporta, aluvijalni vodonosnik]]></keywords_hr><keywords_en><![CDATA[nitrate, groundwater quality, stable isotopes, transport model, alluvial aquifer]]></keywords_en><summary_hr><![CDATA[Nitrat je spoj dušika koji se javlja u prirodni te se pojavljuje u umjerenim koncentracijama u brojnim vodenim sustavima. Visoke koncentracije nitrata su posljedica antropogene aktivnosti. Visoke koncentracije nitrata pojavljuju se u aluvijalnom vodonosniku na području grada Varaždina. Područje istraživanja zahvaća slivna područja crpilišta &#39;&#39;Varaždin&#39;&#39; i &#39;&#39;Vinokoščak&#39;&#39;. Istraživanja koja su provedene na području istraživanja s obzirom na probleme nitrata, su ili iz hidrogeološkog ili poljoprivrednog gledišta. Na području istraživanja nikada nije provedeno sustavno interdisciplinarno istraživanje ponašanja i raspodjele nitrata u vodonosniku koje bi uključivalo različite istraživače iz različitih disciplina, te različite tehnike istraživanja denitrifikacijskih i nitrifikacijskih procesa u vodonosnom sustavu. Šest je glavnih ciljeva TRANITAL projekta:1. Razviti multi-parameterski pristup za određivanje značajki aluvijalnog vodonosnika pomoću hidrauličkih, kemijskih, isotopnih i mikrobioloških pokazatelja2. Odrediti ulogu površinskih voda na napajanje/dreniranje aluvijalnog vodonosnika i njihov utjecaj na koncentraciju dušika u aluvijalnom vodonosniku3. Odrediti mineraloška i kemijska svojstva tla i njegov utjecaj na dušikov ciklus4. Određivanje podrijetla nitrata i procesa koji mogu dovesti do poboljšanja kakvoće podzemne vode5. Načiniti model toka podzemne vode i transporta nitrata u aluvijalnom vodonosniku6. Prenijeti spoznaje o podrijetlu, ponašanju i transportu nitrata u aluvijalnom vodonosnikuGlavni cilj TRANITAL projekta je osigurati znanstveno opravdani pristup i prijenos znanja između znanstvenika iz različitih disciplina koji će istraživati vodonosnike čija je kakvoća narušena zbog visokih koncentracija nitrata te prenijeti znanje upravi, planerima, vodnim grupacijama na lokalnoj i državnoj razini kako bi se osiguralo ekološko održivo upravljanje vodnim resursima i poljoprivrednom proizvodnjom.]]></summary_hr><summary_en><![CDATA[Nitrate is a compound of nitrogen that occurs naturally in moderate concentrations in many aquatic environments. Higher concentrations of nitrate in groundwater are typically caused by anthropogenic activities. High nitrate content is in groundwater of the surrounding area of the town Varaždin. The research area compromise the catchment area of the pumping sites ‘’Varaždin’’ and ‘’Vinokoščak’’. The studies that have been conducted in the research area considering the nitrate problems are from hydrogeological or agricultural point of view. In the research area there were never conducted systematic interdisciplinary research on fate and distribution of nitrate in the aquifer which would include different type of researchers, different techniques of studying denitrification and nitrification processes in the system such as aquifer. There are 6 main objectives in TRANITAL project:1.	To developed multi-parametric approach to characterize alluvial aquifer hydraulic properties and groundwater chemical, isotopic and microbiological properties. 2.	To define the role of surface waters on aquifer recharge and nitrogen cycle. 3.	To define the soil’s mineral and chemical and microbiological properties and its role in nitrogen cycle. 4.	To identify the sources of nitrate that causes the groundwater deterioration and the processes that may assist in groundwater natural attenuation. 5.	To create flow and nitrate transport numerical model of the alluvial aquifer. 6.	Transfer of knowledge about nitrate origin, fate and transport in the alluvial aquifer. The main goal of the TRANITAL project is to provide scientifically justified approach and transfer of knowledge between scientists of different disciplines which will study aquifers with high nitrate concentrations which deteriorate groundwater quality and to transfer the knowledge to decision makers and local water-use groups to ensure environmentally sustainable management of water resources and agricultural production.]]></summary_en></project><project>
<id>4571</id><title_hr><![CDATA[Primjena proteinskih hidrolizata iz pogača lana i konoplje u medijima za uzgoj životinjskih stanica]]></title_hr><title_en><![CDATA[Application of protein hydrolysates from flaxseed and hempseed oil cakes as animal cell culture media supplement]]></title_en><user_id>5279</user_id><user_firstLast_name>Višnja Gaurina Srček</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2016-06</proposal_call><code>IP-2016-06-3848</code><acronim><![CDATA[HYDRO PEP CELL]]></acronim><duration>01.03.2017 - 31.05.2021</duration><status>Završio</status><financ_value>106.943,43 eur</financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Biotehnologija, </scie_field_hr><scie_field_en>Biotechnology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prehrambeno-biotehnološki fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Food Technology and Biotechnology]]></institution_en><team_members_id>3228, 796, 19708, 5443, 797, 6126, 25193, </team_members_id><team_members_names><![CDATA[Ivana Radojčić Redovniković, Jasna Beganović (udana Novak od 23. svibnja 2015.), Igor Slivac, Kristina  Radošević, Andreja Leboš Pavunc, Marina Cvjetko Bubalo, Marijan Logarušić, ]]></team_members_names><keywords_hr><![CDATA[uljne pogače, hidrolizati proteina, kultura životinjskih stanica, medij za uzgoj, CHO stanice]]></keywords_hr><keywords_en><![CDATA[oil cake, protein hydrolysates, animal cell culture, culture media, CHO cells]]></keywords_en><summary_hr><![CDATA[Kulture životinjskih stanica koriste se za proizvodnju visokovrijednih spojeva kao što su rekombinantni proteini. Za uspješan rast, održavanje i produktivnost kultura stanica potreban je medij za uzgoj koji mora sadržavati hranjive tvari, soli, hormone, faktore rasta te serum životinjskog porijekla. Posljednjih desetljeća uočeni su problemi primjene seruma u procesima s kulturama stanica, a koji se očituju u rizicima prijenosa virusa, priona i mikoplazmi te otežanoj izolaciji proizvoda. U cilju prevladavanja nedostataka primjene seruma razvijeni mediji bez seruma koji često sadrže hidrolizate biljnog porijekla. Hidrolizati sadrže aminokiseline, oligopeptide, lipide, vitamine i ostale spojeve koji potiču proliferaciju i produktivnost stanica u kulturi.Nus-proizvodi prehrambene industrije, a među njima i ostaci iz proizvodnje jestivog ulja tzv. pogače, zbog značajnog sadržaja proteina predstavljaju novu potencijalnu sirovinu za primjenu u tehnologiji životinjskih stanica. Pogače lana i industrijske konoplje sadrže 30-35% proteina i kao takve nisu zanemariv izvor proteina koji se može koristiti kao dodatak u medijima za uzgoj životinjskih stanica. Glavni cilj predloženog Projekta jest primjena proteinskih hidrolizata pripravljenih iz pogača lana i konoplje kao dodatka medijima za uzgoj stanica (s i bez seruma). Istražit će se učinak hidrolizata na prinos proizvoda biotehnološkog postupka proizvodnje rekombinantnih proteina obzirom na proliferaciju stanica i proizvodnost. Ukoliko predložena istraživanja budu provedena, rezultati dobiveni ovim Projektom doprinijet će većem ekonomskom iskorištenju nus-proizvoda iz proizvodnje ulja lana i konoplje. Štoviše, u slučaju pozitivnog učinka hidrolizata na rast stanica i proizvodnost rekombinantnih proteina, razvijeni postupak hidrolize te strategija prihranjivanja hidrolizatima tijekom uzgoja stanica, doprinijet će tehnologiji životinjskih stanica na način da će utjecati na oblikovanje medija bez seruma. ]]></summary_hr><summary_en><![CDATA[Animal cell culture has a great importance in production of recombinant proteins. For successful maintenance of animal cell culture, it is essential to ensure culture medium which consists of various nutrients and a blood serum of animal origin. However, the addition of animal sera has always been related to complex isolation of the cell product. Therefore, in order to overcome the obstacles of serum addition, cell culture experts developed serum-free media that still show better performance with addition of protein hydrolysates, preferably of plant origin. Plant hydrolysates are reach source of peptides and amino acids as well as other growth stimulating factors. One of the most promising substances for making these hydrolysates are protein rich by-products of edible oil industry called oil cakes or oil meals. Oil-cakes of flax and industrial hemp seeds contain 30-35% proteins, and as such can be used as a nutritious media supplement for animal cell cultivation. The main objective of the proposed project is to determine the effects of flaxseed and hempseed oil cake hydrolysates on cell proliferation and recombinant protein production. We want to carry out an enzyme based oil cake hydrolysis and apply different hydrolysate fractions and concentrations in cell culture, with or without serum. Defining the parameters of hydrolysis and characterization of derived peptides is the foundation for standardization of the hydrolysate composition and their administration as nutritive supplements for cell culture. The results obtained with this project will contribute to the re-evaluation of waste-products from flax and hemp oil industry and direct their application in the field of animal technology. If positive results were achieved, (i.e. hydrolysates show stimulatory effects on cell growth and productivity), the selected hydrolysate fractions could be used as a beneficial culture media component and thus affect future media formulations.]]></summary_en></project><project>
<id>4572</id><title_hr><![CDATA[Prototip višenamjenskog kompozitnog panela drvo – nosivo staklo]]></title_hr><title_en><![CDATA[Prototype of multipurpose timber - structural glass composite panel]]></title_en><user_id>19348</user_id><user_firstLast_name>Vlatka Rajčić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2016-06</proposal_call><code>IP-2016-06-3811</code><acronim><![CDATA[VETROLIGNUM]]></acronim><duration>01.03.2017 - 29.02.2020</duration><status>Završio</status><financ_value>99.455,84 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Građevinarstvo, Arhitektura i urbanizam, </scie_field_hr><scie_field_en>Civil engineering, Architecture and Urban Environment, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Građevinski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Civil Engineering]]></institution_en><team_members_id>19909, 20254, 20244, 20363, 21350, 369, 21359, 21354, 21365, 21363, 21377, </team_members_id><team_members_names><![CDATA[Mislav Stepinac, Roko Žarnić, Jure Barbalić, Adriana Bjelanović, Ivan Ćurković, Davor Skejić, Ivica Plavec, Valentina Frighi, Roberto Di Giulio, Silvia Brunoro, Meta Kržan, ]]></team_members_names><keywords_hr><![CDATA[staklo, drvo, potres, kompoziti, prototip]]></keywords_hr><keywords_en><![CDATA[glass, timber, earthquake, composites, prototype]]></keywords_en><summary_hr><![CDATA[U posljednjih nekoliko desetljeća došlo je do naglog razvoja stakla kao nosivog materijala. S druge strane, povećanje primjene stakla djelomično je ograničeno jer ne postoje dostupni i odgovarajući propisi koji bi projektantima i izvođačima omogućili širu primjenu stakla. Nosivo staklo u kombinaciji s drvenim okvirom predstavlja kompozitni sustav koji ima predispozicije za dobro ponašanje prilikom potresa, istovremeno je energetski efikasno i isplativo, estetski prihvatljivo te ima dobre nosive karakteristike. U novije vrijeme provedeno je nekoliko istraživanja kompozitnih sustava drvo – nosivo staklo pri monotonim i cikličkim ispitivanjima koja su nužna kako bi kompoziti bili ugradljivi u potresno aktivnim zonama. U projektu će se ispitati ne samo nosiva svojstva panela već i energetska efikasnost cjelokupnog sustava.]]></summary_hr><summary_en><![CDATA[In recent decades there has been a rapid development of glass as a load-bearing material. The increase in the application of glass is partially limited because of the lack of available and appropriate regulations and standards. Structural glass combined with a timber frame is a composite system that has a predisposition for good behavior during an earthquake, it is energy-efficient and cost-effective, aesthetically acceptable and has a good load-bearing characteristics. In recent years, several research projects of composite systems timber - structural glass are in progress. Monotonous and cyclic tests are necessary for composites which will be used in earthquake prone zones. In the project both load bearing and energy efficiency properties of the panel will be tested and the behavior of the panels will be characterized in detail.]]></summary_en></project><project>
<id>4593</id><title_hr><![CDATA[Učinci ekonomskih katastrofa]]></title_hr><title_en><![CDATA[Effects of Economic Disasters]]></title_en><user_id>19176</user_id><user_firstLast_name>Bruno Ćorić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2016-06</proposal_call><code>IP-2016-06-4682</code><acronim><![CDATA[ECONDIS2016]]></acronim><duration>01.01.2017 - 31.12.2019</duration><status>Završio</status><financ_value>41.629,97 eur</financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Ekonomija, </scie_field_hr><scie_field_en>Economy, </scie_field_en><institution_hr><![CDATA[Sveučilište u Splitu, Ekonomski fakultet]]></institution_hr><institution_en><![CDATA[University of Split, Faculty of Economics, Business and Tourism]]></institution_en><team_members_id>19207, 12620, </team_members_id><team_members_names><![CDATA[Vladimir Šimić, Vinko Muštra, ]]></team_members_names><keywords_hr><![CDATA[ekonomske katastrofe, rast outputa, volatilnost outputa, investicije, transmisijski kanali, institucije]]></keywords_hr><keywords_en><![CDATA[economic disasters, output growth, output volatility, investment, transmission mechanisms, institutions]]></keywords_en><summary_hr><![CDATA[Kolaps na tržištu hipotekarnih kredita u ljeto 2007. godine u SAD-u izazvao je jednu od najtežih financijskih i ekonomskih kriza u novijoj povijesti, odnosno prvu globalnu krizu nakon Drugog svjetskog rata. Navedeni događaji pružili su poticaj razvoju pravca u ekonomskoj literaturi usmjerenom na promatranje utjecaja velikih ekonomskih kriza, takozvanih ekonomskih katastrofa. Nakon iznimno važnog istraživanja Barro-a (2006) fokus većine istraživanja je bio usmjeren na moguće učinke ekonomskih katastrofa na cijene financijske imovine i financijska tržišta. Naš prijedlog istraživanja, s druge strane, usredotočuje se na učinke ekonomske katastrofe na realni sektor gospodarstva. To je područje koje je ostalo uglavnom neistraženo u recentnoj literaturi o ekonomskim katastrofama.Naše istraživanje ima tri glavna cilja. U prvom redu istraživanje će sadržavati istragu povezanosti ekonomskih katastrofa i volatilnosti outputa. Preciznije, naš cilj je istražiti promjene u volatilnosti outputa u posljednja dva stoljeća i detektiranje mogućih objašnjenja tih promjena s posebnim osvrtom na ulogu ekonomskih katastrofa. Naš drugi cilj se odnosi na istraživanje dugoročnih učinaka ekonomskih katastrofa na stopu rasta outputa. Fokus je na istraživanju dugoročnih posljedica ekonomske katastrofe na stopu rasta outputa; moguće transmisijske kanale kroz koje ekonomske katastrofe mogu utjecati na rast outputa i ulogu institucija u ekonomskim katastrofama i njihovim dugoročnim učincima. Treći dio ovog istraživanja će se fokusirati na ulogu ekonomske katastrofe u gospodarskoj povijesti Hrvatske. Naš cilj je istražiti ekonomske katastrofe zabilježene u gospodarskoj povijesti Hrvatske; moguće dugoročne učinke ovih ekonomskih katastrofa na stopu rasta outputa i volatilnost outputa; analiziranje i predviđanje mogućih negativnih dugoročnih posljedica sadašnje krize i predlaganje mjera za sprečavanje ili ublažavanje tih negativnih posljedica.]]></summary_hr><summary_en><![CDATA[The collapse of the subprime mortgages market in the summer of 2007 in US triggered one of the most severe financial and economic crises in recent history and the first global economic downturn after the Second World War. These events give impetus to the new literature on the effects of large economic crises, the so called economic disasters. Following groundbreaking Barro’s (2006) study most of these researches focus on the possible effects of economic disasters on asset pricing and financial markets. Our research proposal, on the other hand, focuses on the effects of economic disasters on the real sector of economy. This is the area that has remained largely uninvestigated by the recent literature on economic disasters. 	Our research has three main goals. The first line of enquiry will comprise an investigation of the relationship between economic disasters and output volatility. In particular, our goal is to investigate changes in output volatility over the last two centuries and to provide possible explanation(s) for these changes with a special reference to the role of economic disasters. Our second line of enquiry will include an investigation of the long-run effects of economic disasters on output growth. The goal is to investigate the long-run effects of economic disasters on output growth; the possible transmission channels through which economic disasters can affect output growth, and the role of institutions in economic disasters and their long-run effects. The third part of this research is going to focus on the role of economic disasters in Croatian economic history. Our goal is to investigate economic disasters in the recorded economic history of Croatia; the possible long-run effects of these economic disasters on output growth and output volatility; to analyze and predict possible negative long-run effects of current crisis and suggest policy measures for prevention or amelioration of these negative consequences.]]></summary_en></project><project>
<id>4595</id><title_hr><![CDATA[Politike identiteta i hrvatska drama od 1990. do 2016.]]></title_hr><title_en><![CDATA[Identity Politics and Croatian Drama from 1990 to 2016]]></title_en><user_id>13758</user_id><user_firstLast_name>Zlatko Kramarić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2016-06</proposal_call><code>IP-2016-06-4316</code><acronim><![CDATA[PoIHDrama]]></acronim><duration>01.04.2017 - 31.03.2021</duration><status>Prekinut</status><financ_value>70.151,97 eur</financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Filologija, Znanost o umjetnosti, </scie_field_hr><scie_field_en>Philology, Arts, </scie_field_en><institution_hr><![CDATA[Sveučilište Josipa Jurja Strossmayera u Osijeku, Građevinski i arhitektonski fakultet Osijek]]></institution_hr><institution_en><![CDATA[Josip Juraj Strossmayer University of Osijek, Faculty of Civil Engineering and Architecture Osijek]]></institution_en><team_members_id>13740, 19293, 13737, 19561, 13752, 19633, </team_members_id><team_members_names><![CDATA[Lucija Ljubić, Martina Petranović, Ivan Trojan, Višnja Kačić Rogošić, Ivana Žužul, Kristina Peternai Andrić , ]]></team_members_names><keywords_hr><![CDATA[politike identiteta, hrvatska drama, hrvatsko kazalište, književna historiografija, kazališna historiografija]]></keywords_hr><keywords_en><![CDATA[identity politics, Croatian drama, Croatian theatre, literary historiography, theatre historiography]]></keywords_en><summary_hr><![CDATA[Budući da se hrvatskoj drami nastaloj od 1990. do 2016. zasad pristupalo parcijalno i većinom iz vizure jedne istraživačke osobnosti, projektnim prijedlogom Politike identiteta i hrvatska drama od 1990. do 2016. obuhvatit će se cjelovit dramski korpus navedenog razdoblja, a predmet istraživanja proširit će se analizom teksta nastalog tijekom rada na predstavi ili na samoj izvedbi u okviru samostalnih autorskih ili kolektivnih kazališnih predstava. Projektni prijedlog teorijsko-metodološki počiva na rodnim studijima i antiesencijalističkim teorijama nacije, a termin politike identiteta preuzet je iz recentnih proučavanja identiteta utemeljenih na izvođenju pojma razlike u poststrukturalizmu i dekonstruiranju esencijalističkog pristupa pojmu u kojem je identitet reprezentiran kao nedjeljiv, neproblematičan i prirodan. Istraživanje polazi od pretpostavke da kazališne, književne, kazališnopovijesne i književnopovijesne reprezentacije te druge narativne konstrukcije navedenog dramskog korpusa imaju važne implikacije u samoprepoznavanju i oblikovanju vlastitog nacionalnog identiteta i zato su u središtu interesa odnosi rodnog i nacionalnog identiteta, ali i drugih kolektivnih identiteta. Analizirat će se i institucionalni okviri unutar kojih nastaje i opstaje hrvatska drama, odnos hrvatske drame i kazališta, međunarodna recepcija i medijska slika hrvatske drame te učinci prešutnih naknadnih književnohistoriografskih i kazališnohistoriografskih teorijskih sudova i konstrukata koji skrivaju institucionalne napukline kanona književnosti i kazališta kao i bilo kojeg drugog identiteta. ]]></summary_hr><summary_en><![CDATA[Since the Croatian drama produced from 1990 to 2016 has been approached partially and mostly from a perspective of a singular researcher persona, the project proposal Identity Politics and Croatian Drama from 1990 to 2016 will encompass a comprehensive dramatic corpus of the adduced period, whereby the research topic will be expanded by an analysis of the text produced while working on a show or at a performance itself within the auctorial or collective theatrical performances. Theoretically and methodologically, the project proposal relies on gender studies and anti-essentialist nation theories, and the identity politics term is assumed from the recent identity studies based on a derivation of a notion of difference in poststructuralism and in a deconstruction of an essentialist approach to the term, in which identity is represented as inseparable, unproblematic, and natural. The research starts from a hypothesis that the theatrical, literary, theatrical-historical and historico-literary representations and other narrative constructions of the aforementioned dramatic corpus exert significant implications in a self-recognition and formulation of a proper national identity, because of which the relationships between a gender-based and national identity, as well as of other collective identities, are in the center of interest. The institutional frameworks within which the Croatian drama is being produced and sustained, a relationship between the drama and theatre, an international reception and a media picture of the Croatian drama, and the effects of the tacit subsequent literary-historiographic and theatrical-historiographic theoretical judgments and constructs that conceal the institutional flaws in the canons of literature and theatre and any other identity, will also be analyzed. ]]></summary_en></project><project>
<id>4600</id><title_hr><![CDATA[Inovativne tehnike u minimalnoj preradi krumpira (Solanum tuberosum) i njegova zdravstvena ispravnost nakon pripreme]]></title_hr><title_en><![CDATA[Innovative techniques in potato minimal processing (Solanum tuberosum) and its safety after preparation]]></title_en><user_id>2644</user_id><user_firstLast_name>Branka Levaj</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2016-06</proposal_call><code>IP-2016-06-5343</code><acronim><![CDATA[IMPROvePOTATO]]></acronim><duration>01.03.2017 - 30.06.2021</duration><status>Završio</status><financ_value>126.219,39 eur</financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Prehrambena tehnologija, </scie_field_hr><scie_field_en>Food technology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prehrambeno-biotehnološki fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Food Technology and Biotechnology]]></institution_en><team_members_id>19066, 12848, 1062, 19143, 1330, 13351, 20284, 20040, 20300, 25271, 25824, </team_members_id><team_members_names><![CDATA[Kata Galić, Sandra Balbino, Sandra Pedisić, Mario  Ščetar, Maja Repajić, Filip Dujmić, Sanja Loncaric, Draženka Dite, Milan Poljak, Zdenka Pelaić, Zrinka Čošić, ]]></team_members_names><keywords_hr><![CDATA[minimalno prerađeni krumpir, visoki hidrostatski tlak, ultraljubičasto svjetlo, ultrazvuk , akrilamid, piliciklički aromatski ugljikovodici]]></keywords_hr><keywords_en><![CDATA[minimally processed potatoes, high hydrostatic pressure, ultraviolet light, ultrasound, acrylamide, polycyclic aromatic hydrocarbons]]></keywords_en><summary_hr><![CDATA[Krumpir (Solanum tuberosum) je široko raspstranjeno povrće, vrlo često u prehrani ljudi, prikladno za skladištenje u neprerađenom stanju i do jedne godine. Kompleksnog je kemijskog sastava podložnog promjenama ovisno o uvjetima i duljini skladištenja. Priprema se za jelo na različite načine pri čemu, također, dolazi do određenih poželjnih i nepoželjnih promjena u kemijskom sastavu. U Hrvatskoj se krumpir većinom plasira na tržište neprerađeni ili u manjoj mjeri prerađen u čips i sl. snack proizvode. U drugim zemljama prerada krumpira je u porastu pri čemu minimalno prerađeni krumpir - MPK (oguljen, opran, narezan, zapakiran, toplinski neobrađen) postaje sve traženiji. Iako vrlo praktičan, takav proizvod je kratkog vijeka trajanja (uobičajeno 7 dana) i sklon je posmeđivanju te je vrlo zahtjevan za proizvodnju i čuvanje (pri temperaturi ne višoj od 8oC). Cilj ovog projekta je stjecanje spoznaja koje bi pomogle u proizvodnji MPK. Konkretnije stjecanje znanja o kemijskom sastavu različitih sorata krumpira i njegovim promjenama tijekom skladištenja te o načinima sprječavanja enzimskog posmeđivanja narezanog krumpira, stjecanju spoznaja o mogućim utjecajima na održavanje poželjnog kemijskog sastava u cilju smanjenja nastanka nepoželjnog akrilamida usljed prženja i pečenja krumpira te o načinu provedbe prženja da udjel policikličkih aromatskih ugljikovodika koji putem ulja dospijevaju u prženi krumpir bude minimalan. Nadalje, cilj je stjecanje spoznaja o utjecaju netoplinskih tehnologija (ultrazvuka visokog intenziteta - UZV, visokog hidrostatskog pritiska - HHP i ultraljubičastvog svjetla - UV-C) na kemijski sastav i posljedično na stabilnost MPK pri različitim uvjetima čuvanja. Konačni cilj je optimiranje proizvodnje MPK što uključuje definiranje optimalne sorte, postupka za sprječavanje posmeđivanja (s ili bez UZV), ambalaže i uvjeta pakiranja, te primjene netoplinskih tretmana (HHP i UV-C) u svrhu produljenja trajnosti te mogućnosti čuvanja pri sobnoj temperaturi.]]></summary_hr><summary_en><![CDATA[Potato (Solanum tuberosum) is a widespread vegetable, often used in human diet, suitable for storage as unprocessed up to one year. It has a complex chemical composition susceptible to changes depending on the conditions and duration of storage. It could be prepared for consumption in many ways by which favorable or unfavorable changes in the chemical composition also occur. In Croatia, the majority of potatoes is marketed unprocessed or, to a lesser extent, processed as chips and similar snacks. In other countries, processing of potatoes is increasing with minimally processed potatoes - MPP (peeled, washed, sliced, packaged, untreated by heat) becoming more popular. Although very convenient, such product has short shelf life (usually 7 days), is susceptible to browning and very demanding for production and storage (at temperature lower than 8 °C). The aim of this project is to acquire knowledge that would help in the production of MPP, specifically on the chemical composition of different potato varieties, their changes during storage and preventing enzymatic browning of sliced potatoes. It will also deal with the effects for guarding suitable chemical composition in order to reduce the formation of undesired acrylamide, a result of potatoes frying and baking, and with the frying method that would minimize the level of polycyclic aromatic hydrocarbons from oil in the fried potatoes. Furthermore, the goal is to acquire knowledge about the impact of non-thermal technologies (high intensity ultrasound, high hydrostatic pressure and ultraviolet light) on the chemical composition and consequently the stability of the MPP at different storage conditions. The main goal is to optimize the manufacture of MPP including the selection of the optimal variety, the procedure to prevent browning, the packaging and the packaging conditions and the application of non-thermal treatment in order to prolong durability and make possible storage at room temperature.]]></summary_en></project><project>
<id>4603</id><title_hr><![CDATA[Novel Characterizations of Classical and Quantum Many-Body Systems]]></title_hr><title_en><![CDATA[Novel Characterizations of Classical and Quantum Many-Body Systems]]></title_en><user_id>20277</user_id><user_firstLast_name>Fabio Franchini</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2016-06</proposal_call><code>IP-2016-06-3347</code><acronim><![CDATA[ManyBodyCharacteriza]]></acronim><duration>01.05.2017 - 31.08.2021</duration><status>Završio</status><financ_value>129.006,57 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, </scie_field_hr><scie_field_en>Physics, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>6532, 11143, 25292, 28968, 28967, 28970, 26810, 29625, </team_members_id><team_members_names><![CDATA[Ivan Balog, Vinko Zlatić, Vanja Marić, Andrei Fedorenko, Domagoj Kuić, Luka Sinković, Salvatore Marco Giampaolo, Jovan Odavić, ]]></team_members_names><keywords_hr><![CDATA[mnogočestični sustavi, nered, lokalizacija, lavine, Isingov model u nasumičnom polju, neperturbativna renormalizacijska grupa, kvantno sprezanje]]></keywords_hr><keywords_en><![CDATA[Many-body systems, Disorder, Localization, Avalanches, Random Field Ising Model, Non-perturbative Renormalization Group, Entanglement]]></keywords_en><summary_hr><![CDATA[Više je različito napisao je P.W.Anderson godine 1972, objašnjavajući kako je glavni izazov moderne fizike razumjeti i opisati kako interakcija velikog broja elemenata dovodi do novih i kompleksnih ponašanja, koji se ne mogu objasniti preko ponašanja izvornih konstituenata.   Kako bismo identificirali najbolje varijable i pristupe nekoliko prototipskih modela, skupili smo stručnjake iz raznih aspekata kompleksih sustava.Koristit ćemo jednostavni model sa specifičnim svojstvima, kako bismo razumjeli odnos između novootkrivene vrste spontanog loma simetrije, lokalizacije i staklastog ponašanja, s primjenama u fizici čvrstog stanja i kompleksnih sustava (a možda i teoriji struna). Ovaj model je formuliran u preko članova velike matrice i već je prije povezan s metal/izolator prijelazom i Chern-Simons/topološkim teorijama struna. Nedavno je otkriveno kako je netrivijalni spontani lom simetrije koji se javlja u tom modelu odraz vrlo složenog energetskog krajolika, kojeg karakterizira parametarski velik broj ravnotežnih konfiguracija (sedla particijske funkcije). Takvo ponašanje je primjer kompleksnog sustava i može ga se opisati tim movim tipom loma simetrije.Paralelno tome istražiti ćemo jednodimenzionalni model s dugodosežnim interakcijama, kako bismo modelirali ponašanje Isingovog modela u nasumičnom polju i proučili critično ponašanje s naglaskom na fenomenologiju lavina. U ovom modelu efektivna dimenzija je enkodirana u parametru dosega interakcija, što nam dozvoljava prilagođavanje necjelobrojnoj dimenziji u kojoj se događa ponašanje koje nam je interesantno.Također ćemo se baviti jako interagirajućim kvantnim sustavima i njihovim svojstvima kvantnog sprezanja, kako bismo shvatili način na koji informacijska teorija može pomoći u razaznavanju specijalne prirode multi-kritičnih, ne-konformnih točaka. Kvantno sprezanje je suštinski povezano s kvantnim računanjem i koristit ćemo novu veličinu, koja se zove nelokalna konvertibilnost.]]></summary_hr><summary_en><![CDATA[More is Different wrote P.W. Anderson in 1972, explaining that the central challenge of modern physics is to understand how the interaction of a large number of elementary constituents can lead to the emergence of novel, complex behaviors, which can hardly be explained in terms of the original ingredients.In order to identify the appropriate variables and formalism to capture the behavior of a few prototypical toy models, we will assemble expertise in different types of complex systems.On one side, we will use a toy model understand the relation between a novel spontaneous symmetry breaking (SSB), localization and glassiness, with applications in condensed matter and complex systems. This model is formulated in terms of large matrices and has already been linked to the metal/insulator transition from one side, and to the Chern-Simons/topological string theories from another. More recently, it was understood that the conjectured nontrivial SSB realized in this model is the reflection of a complex energy landscape, characterized by a parametrically large number of equilibrium. Such a behavior is paradigmatic of a complex system and thus it can be captured by a new type of replica symmetry breaking.In a parallel effort, we will use a one dimensional model with long range interaction as a tool to model the behavior of the random field Ising model in different dimensions and to study the critical exponents and avalanche phenomenology. In the toy model, the effective dimension is encoded in decay rate of the long range interaction and thus allow for a fine tuning even to relevant “fractional” dimensions emerging from non-perturbative-RG.We will also tackle strongly interacting quantum systems and their entanglement properties, to understand how information theory can help in discriminating the special nature of multi-critical, non-conformal points and the computational power of topological phases through non-local convertibility.]]></summary_en></project><project>
<id>4608</id><title_hr><![CDATA[Ciljana izrada prototipa vlaknastog nosača za uzgoj tkivnih stanica kombiniranim elektroispredanjem]]></title_hr><title_en><![CDATA[Custom Tailored Fibrous Scaffold Prototype for Tissue Cells Culture via Combined Electrospinning]]></title_en><user_id>443</user_id><user_firstLast_name>BUDIMIR MIJOVIĆ</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2016-06</proposal_call><code>IP-2016-06-6878</code><acronim><![CDATA[COMBOELECTROSPUN]]></acronim><duration>01.03.2017 - 31.08.2021</duration><status>Završio</status><financ_value>128.701,43 eur</financ_value><scie_area_hr>Tehničke znanosti, Biotehničke znanosti, </scie_area_hr><scie_area_en>Technological sciences, Biotechnical sciences, </scie_area_en><scie_field_hr>Tekstilna tehnologija, Kemijsko inženjerstvo, Strojarstvo, Biotehnologija, </scie_field_hr><scie_field_en>Textile technology, Chemical engineering, Mechnical engineering, Biotechnology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Tekstilno-tehnološki fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Textile Technology]]></institution_en><team_members_id>19773, 826, 4848, 3644, 7628, 20048, 5286, 6487, 19708, </team_members_id><team_members_names><![CDATA[Emi Govorčin Bajsić, Tamara Holjevac Grgurić, Mirna Tominac Trcin, Emilija Zdraveva, Tamara Dolenec, Ivana Vrgoč, Iva Dekaris, Xungai Wang, Igor Slivac, ]]></team_members_names><keywords_hr><![CDATA[elektroispredanje, nosači, antibakterijsko svojstvo, faktor rasta, stanice]]></keywords_hr><keywords_en><![CDATA[electrospinning, scaffolds, antibacterial property, grow factor, cells]]></keywords_en><summary_hr><![CDATA[Glavni cilj ovog interdisciplinarnog projekta je ciljani razvoj prototipa vlaknastog nosača za uzgoj tkivnih stanica, temeljen na tekstilnoj tehnici elektroispredanja. Veliki izazov u elektroispredanju nosača je potreba za strukturom s porama dovoljno velikog promjera (makro skala) kako bi se olakšalo prodiranje stanica i vlaknima dovoljno malog promjera (nano skala) kako bi oponašali prirodno izvanstanično okruženje. Jedinstveni doprinos ovog projektnog prijedloga temelji se na kombinaciji dviju tehnika elektroispredanja. Elektroispredanje iz otopine i taline će se koristiti za izradu nosača kombiniranih nanovlaknastih i mikrovlaknastih slojeva. Površinska adhezija stanica biti će dodatno poboljšana s izradom ciljane topografije površine nosača, pripremljene elektroispredanjem na metalnim kolektorima s ciljanom poroznošću. Drugi aspekt je izrada nosača ciljanih funkcija, uključujući antibakterijsko svojstvo i svojstvo stimulacije staničnih procesa pomoću bioloških komponenti. Konačni cilj projekta je odabrati nosače s optimalnom strukturom i multifunkcionalnošću. Multifunkcionalnost nosača će se temeljiti na sustavnom istraživanju s ciljem definiranja  optimalnih uvjeta za posjedovanje antibakterijskih svojstava i svojstava kontroliranog oslobađanja biološke komponente. Predloženi materijali za izradu nosača su polikaprolakton i poliuretan kao matrice u kombinaciji s fibroinom svile za dodatno poboljšanje površinske adhezije stanica. Nosači će biti sustavno istraživani i u smislu mehaničkih svojstava, kako bi ispunili konstrukcijske zahtjeve za čvrstoću, a to je da se mogu oduprijeti opterećenjima nastalim uslijed formiranja tkiva.Treći aspekt projekta je validacija fizičke strukture i funkcionalnosti nosača in vitro. Model stanica će uključivati stanice kože i oka. Stanice će se pratiti kroz procjene imunoloških, mikrobioloških, biokemijskih i enzimskih aktivnosti, nakon čega slijedi antibakterijski test, te test citotoksičnosti i kancerogenosti.]]></summary_hr><summary_en><![CDATA[The main focus of this interdisciplinary project proposal is the development of custom tailored fibrous scaffold prototype for cells culture based on the textile technique of electrospinning. The big challenge in electrospun scaffolds is the need of a dual structure, i.e. pores with diameters big enough (macro scale) to facilitate cells penetration and fibres small enough (nano scale) to mimic the native extracellular matrix. The unique contribution of this project proposal is based on the combination of both techniques of electrospinning. Solution electrospinning and melt electrospinning to be used for the fabrication of nano fibers and micro fibers alternating layered scaffolds. Additionally cells surface adhesion will be enhanced by a target surface topography prepared based on custom tailored collectors. The second aspect is the design of scaffolds custom functionality including antibacterial property and cellular processes stimulating property based on biological compounds. Project final goal is to select scaffolds with optimal architecture and introduce them with multifunctionality. Scaffolds multifunctionality will be based on systematic study of the optimal condition defining co-existence of both functions, the antibacterial property and controlled release of the biological compounds. Scaffolds materials are polycaprolactone and polyurethane as the matrices combined with silk fibroin to further enhance cells surface adhesion. The scaffolds will be studied systematically in regard to their mechanical integrity as well, to meet the requirements of a construction, stiff enough to withstand neo-tissue formation. Project third aspect is the validation of the scaffolds physical structure and functionality in vitro. Model cells will include both skin and ocular cells culture. Cells will be monitored through immunological, microbiological, biochemicals and enzyme activity evaluations, followed by antibacterial, citotoxicity and carcinogenicity tests.  ]]></summary_en></project><project>
<id>4615</id><title_hr><![CDATA[Govori Makarskoga primorja - dijakronija i sinkronija]]></title_hr><title_en><![CDATA[The Dialects of Makarska Coast: Diachronic and synchronicapproaches]]></title_en><user_id>3092</user_id><user_firstLast_name>Ivana Kurtović Budja</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2016-06</proposal_call><code>IP-2016-06-8448</code><acronim><![CDATA[GOMAPRIDISI]]></acronim><duration>20.03.2017 - 19.03.2021</duration><status>Prekinut</status><financ_value>52.735,22 eur</financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Filologija, </scie_field_hr><scie_field_en>Philology, </scie_field_en><institution_hr><![CDATA[Institut za hrvatski jezik]]></institution_hr><institution_en><![CDATA[Institute of Croatian Language]]></institution_en><team_members_id>20359, 13303, 1446, 20358, 4665, </team_members_id><team_members_names><![CDATA[Jurica Budja, Filip Galović, Lucija  Šimičić, Dijana Ćurković, Mario Essert, ]]></team_members_names><keywords_hr><![CDATA[govori Makarskoga primorja, dijakronija, sinkronija, dijalektologija, sociolingvistika, korpus, mrežni okvir]]></keywords_hr><keywords_en><![CDATA[Dialects of Makarska coast, Diachronic and synchronic approaches, dialectology, sociolinguistics, textology, network framework ]]></keywords_en><summary_hr><![CDATA[Makarsko je primorje u povijesti bilo zatvorena zemljopisna i politička jedinica zbog svojega zemljopisnog položaja. Sa sjevera graniči s Poljicima, a s juga s Neretvanskom krajinom. Ono je bilo dijelom zapadnoštokavskoga dijalekta hrvatskoga jezika koji se raspao nakon osmanlijskih osvajanja. S migracijama je došlo do preraspodjele dijalekata koji su postojali prije seobe oko ušća Neretve pa su se nakon odlaska govornika biokovsko-cetinskog dijalekta u Istru i Molise (Italija) našli u kontaktu ikavskošćakavski imotski govori nekadanjega livanjsko-vrbaskog dijalekta i ikavskošćakavski govori nekadanjega makarskoprimorskog dijalekta. Cilj je ovoga četverogodišnjeg projekta sustavno dijalektološki istražiti govore Makarskoga primorja, govore u njihovoj okolici te iseljeničke govore u Moliseu. Specifični je cilj projekta povijesnojezično istraživanje kojim će se na korpusu tekstova iz Makarskoga primorja u rasponu od 17. do 19. stoljeća pratiti specifične makarskoprimorske jezične crte čime će se dokazati kontinuitet jezika od najstarijih pisanih spomenika do danas. Uz to provest će se i sociolingvističko istraživanje stavova mladih o svom govoru. Pretpostavka je da su današnji govori Makarskoga primorja dijelom prežitak staroga zapadnoštokavskoga dijalekta. Istraživanje će intenzivnim terenskim i arhivskim radom i uobičajenim metodama provoditi skupina od šest znanstvenika i jednoga doktoranda uz podršku ispitanika iz svake jezične zajednice. Dobiveni rezultati bit će računalno obrađeni i pretraživi prema jezičnim karakteristikama sa sinkronijskoga i dijakronijskoga gledišta čime će se pokazati kontinutit ili diskontinuitet svake od njih. Inovativnost je ovoga projekta što povezuje sinkronijsko i dijakronijsko istraživanje skupine govora te rezultate, zahvaljujući računalnoj obradi, čini javnosti dostupnima.]]></summary_hr><summary_en><![CDATA[In history, the Makarska coast was a closed geographical and political unit due to its geographic position.  The goal of this four year project is to conduct a systematic dialectological analysis of the dialects of Makarska coast, the dialects in their vicinity, and the emigrant dialects in Molise. The specific goal of the project is to use the methods of historical linguistics to analyze the corpus of texts written in the area of Makarska coast from 17th to 19th century, in order to establish the linguistic features which would prove that there is a continuity of language from the oldest written texts until today. Apart from those two goals, a sociolinguistic research of attitudes towards the dialect will be conducted.The hypothesis is that the contemporary dialects of Makarska coast are, for the most part, a continuation of the former West Štokavian dialect. The research includes intensive field and archive research, and will be conducted by six scientists and a postgraduate student, with support by local informants from each observed community. The results will be computationally processed and searchable by linguistic characteristics from a synchronic and a diachronic point of view, and the continuity or discontinuity of each of them will be observable. The innovativeness of this project is in that it connects the synchronic and diachronic research of a group of local dialects, as well as in the availability of its data and results to the public, due to the computational processing.]]></summary_en></project><project>
<id>4629</id><title_hr><![CDATA[Plazmonički alternativni materijali za konverziju solarne energije]]></title_hr><title_en><![CDATA[Plasmonic alternative materials for solar energy conversion]]></title_en><user_id>812</user_id><user_firstLast_name>Jordi Sancho-Parramon</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>PKP</proposal_type><proposal_call>2016-06</proposal_call><code>PKP-2016-06-4469</code><acronim><![CDATA[PAMSEC]]></acronim><duration>01.06.2017 - 31.05.2019</duration><status>Završio</status><financ_value>142.544,30 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, Kemija, </scie_field_hr><scie_field_en>Physics, Chemistry, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>20425, 2656, 20041, 20097, 21151, 2916, 25286, </team_members_id><team_members_names><![CDATA[Josep Ferré-Borrull, Boris Okorn, Zoran Ereš, Ivana Fabijanić, Stefano (Antonio) Mezzasalma, Vesna Blažek Bregović, Matej Bubaš, ]]></team_members_names><keywords_hr><![CDATA[plazmonički materijali, konverzija solarne energije, tanki slojevi, metalne nanočestice, obnovljivi izvori energije]]></keywords_hr><keywords_en><![CDATA[plasmonics, solar energy conversion, thin films, metal nanoparticles, renewable energy sources]]></keywords_en><summary_hr><![CDATA[Općeprihvaćen temelj ublažavanja efekata klimatskih promjena jest upotreba obnovljivih i održivih izvora energije, od kojih je osnovna upravo sunčeva energija. Efikasna konverzija solarne energije (KSE) će omogućiti fotovoltaicima, foto-termalnim tehnologijama, kao i tehnologiji skladištenja vodika na bazi svjetla da zamjene fosilna goriva i smanje proizvodnju stakleničkih plinova. Kao obećavajući put ka poboljšanju KSE se nedavno pojavilo područje plazmonike. Prilikom pobude plazmoničkih rezonancija unutar metalnih nano-struktura javlja se jaka interakcija između svjetla i materije koja može omogućiti vrlo efikasno iskorištavanje sunčevog svjetla. Iako je nekolicina eksperimenata pokazala prednosti koje plazmonika pruža za KSE, svi su temeljeni na rijetkim i skupim plazmoničkim materijalima poput zlata i srebra te koriste tehonloški vrlo zahtjevne metode nano-strukturiranja.Unutar ovog projekta planiramo povećati efikasnost KSE iskorištavanjem plazmoničkih svojstava širokodostupnih materijala poput aluminija i bakra, te njihovih legura sa srebrom i zlatom. Čini se da loša svojstva tih materijala za određene plazmoničke primjene poput vođenja valova i senzora mogu biti zaobiđena za primjene KSE-a. Navedeni materijali će biti nano-strukturirani korištenjem metoda tankih slojeva i post-depozicijskih tehnika koje su pogodne za niske cijene i masovnu proizvodnju budućih sustava. Potencijalne prednosti i ograničenja tih materijala će se istražiti korištenjem elektrodinamičkih i ab-initio simulacija, te verificirane izradom i karakterizacijom uzoraka. Metalne nano-strukture će biti optimizirane za specifične KSE sustave. Naročito ćemo se fokusirati na cijepanje vode i generiranje vodene pare kao reprezentativnih primjera KSE na velikim i malim skalama. Uspješno ostvarenje projektnih ciljeva će podići potencijal plazmonike iznad nivoa demonstracije i započeti put njezine uspješne implementacije u stvarnim industrijskim primjenama efikasnog iskorištavanja sunčevog svjetla.]]></summary_hr><summary_en><![CDATA[The use of sunlight as the basis for renewable and sustainable energy has been acknowledged as one of the cornerstones for climate change mitigation. Efficient solar energy conversion (SEC) will empower photovoltaics, photothermal and hydrogen photogeneration technologies as competitive candidates to replace fossil fuels and decrease greenhouse gas production in a close future. Recently, plasmonics has appeared as a promising pathway to enhance SEC. The strong light-matter interaction that takes place during excitation of plasmon resonances in metal nanostructures may lead to very efficient sunlight harvesting. Although several experiments have proven the benefits of plasmonics for SEC, they are based on scarce and expensive plasmonic materials (gold and silver) and often use technologically demanding nanostructuring methods. In the present project we aim to increase SEC efficiency by exploiting the plasmonic properties of widely available materials such as aluminum, copper and their alloys with silver and gold. It has been suggested that limitations of these materials for certain plasmonic applications such as waveguiding and sensing can be by-passed for SEC purposes. The materials will be nanostructured using thin film methods and post-depostion treatments that are suitable for low-cost and mass-production of future devices. The potential benefits and limitations of the materials will be investigated using electrodynamics and first-principle numerical simulations and verified by fabrication and characterization of samples in the laboratory. Optimization of material nanostructures will be carried out for specific SEC systems. In particular, we focus on water splitting and steam generation as representative examples of large and small scale SEC schemes. The successful achievement of the project goals will bring the potential of plasmonics beyond the demonstration level and set it on its path towards its implementation in actual solar light harvesting.]]></summary_en></project><project>
<id>4642</id><title_hr><![CDATA[Evaluacijski sustav za ublažavanje CO2]]></title_hr><title_en><![CDATA[EVALUATION SYSTEM FOR CO2 MITIGATION]]></title_en><user_id>5411</user_id><user_firstLast_name>Domagoj Vulin</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>PKP</proposal_type><proposal_call>2016-06</proposal_call><code>PKP-2016-06-6917</code><acronim><![CDATA[ESCOM]]></acronim><duration>01.04.2017 - 31.03.2019</duration><status>Završio</status><financ_value>85.919,44 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Rudarstvo, nafta i geološko inženjerstvo, Strojarstvo, </scie_field_hr><scie_field_en>Mining, petroleum and geological engineering, Mechnical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Rudarsko-geološko-naftni fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Mining, Geology and Petroleum Engineering]]></institution_en><team_members_id>12942, 13694, 20462, 992, 5703, 5498, 23956, 24003, </team_members_id><team_members_names><![CDATA[Luka Perković, Marija Macenić, Lucija Jukić, Daria Karasalihović Sedlar, Bruno Saftić, Tomislav Kurevija, Maja Arnaut, Amalia Lekić, ]]></team_members_names><keywords_hr><![CDATA[Energetska efikasnost, CO2 emisije, otpadna toplina, naftna i plinska industrija, podzemno skladištenje energije, podzemno skladištenje CO2]]></keywords_hr><keywords_en><![CDATA[Energy efficiency, CO2 emissions, waste heat, oil and gas industry, underground energy storage, underground CO2 storage]]></keywords_en><summary_hr><![CDATA[Naftna i plinska industrija je energetski visoko-intenzivna te proizvodi velike količine CO2. U Hrvatskoj, pored aktivnosti naftne kompanije, termoelektrana i toplana koji se mogu smatrati tzv. točkastim izvorima CO2, manje kompanije ne primjenjuju novije, efikasnije tehnologije. Takve tehnologije moguće je unaprijediti i pri istraživanju i proizvodnji nafte i plina (upstream). Analiza ostvarivosti primjene novih metoda i tehnologija dala bi temelj za dalja istraživanja i analize mogućnosti smanjenja CO2 u ostalim sektorima. Potrebno je izraditi alat u vidu online aplikacije za početne procjene primjene metoda u smislu računanja energije, emisija i troškova bez mjera i istih parametara nakon primjene neke od dostupnih metoda.Na temelju cjelovite sheme za balansiranje električne i toplinske energije, kao i kretanja emisija CO2 i logistike plina vezano uz upstream aktivnosti, analizirale bi se prvo nepostojeće komponente, s ciljem procjena mjera smanjenja emisija CO2 u atmosferu.Pri tome su prisutna dva suprotstavljena cilja s gledišta sveukupne društvene koristi, a to su:(1) maksimiranje smanjenja emisija CO2 (i ostalih ekvivalentnih emisija) u atmosferu s obzirom na investicije, relativno u odnosu na scenarij „bez mjera“(2) maksimiranje sveukupne neto sadašnje vrijednosti (NPV) kao rezultat investicija u projekte smanjenja CO2Dva suprotstavljena cilja vode do rješavanja problema metodom višekriterijske optimizacije, s ciljem pronalaska optimuma opće društvene koristi. Nakon gore opisane analize, izradit će se generički proračuni svakog analiziranog elementa koji bi se modularno mogli uključivati u novi dizajn pojedinih procesa. Zajedno s izrađenom relacijskom bazom prikupljenih podataka, takvi algoritmi bi radili u obliku online aplikacije te omogućili inicijalne analize primjene pojedinih metoda u drugim sektorima i otvoreni pristup informacijama i analizama.]]></summary_hr><summary_en><![CDATA[Oil and gas industry is highly energy intensive and produces significant amounts of CO2. In Croatia, besides activities of oil company and thermal and power plants which can be considered as point sources of CO2, there are small companies which are not implementing new more efficient technologies. There is a room for an improvement for CO2 mitigation at upstream activities during hydrocarbon exploration and production also. The analysis of feasibility of available methods in upstream activities could help to develop the basis for further research and analysis of possibilities for CO2 emission reduction in other sectors. A tool for initial screening of available methods should be developed in form of online application which could calculate energy, cost and CO2 emission without measures (without more efficient methods applied) and the same three parameters with measures. Based on overall heat and power energy scheme, including the CO2 flow path and natural gas logistics related to upstream activities, non-existing components would be analysed with two opposed main objectives in estimation of the overall social welfare:(1) maximization of the CO2 (and equivalent) emission reduction into the atmosphere as a result of CO2 mitigation projects, relative to scenario without measures(2) maximization of the overall net present value (NPV) as a result of investment into the various CO2 mitigation projectsThe two opposing objectives lead to multiobjective optimization, where the overall optimum of social welfare can be found.After such analysis, generic set of equations will be generated for each analysed element in order to design new process in a modular way. Altogether with created relational database, such algorithms would be implemented to online application which would provide screening of applicability of methods to other sectors and open access to information and analysis.]]></summary_en></project><project>
<id>4647</id><title_hr><![CDATA[Novi materijali za pohranu energije]]></title_hr><title_en><![CDATA[New materials for energy storage]]></title_en><user_id>625</user_id><user_firstLast_name>Ivan Halasz</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>PKP</proposal_type><proposal_call>2016-06</proposal_call><code>PKP-2016-06-4480</code><acronim><![CDATA[NEWMATENG]]></acronim><duration>15.05.2017 - 14.05.2019</duration><status>Završio</status><financ_value>260.415,42 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, </scie_field_hr><scie_field_en>Chemistry, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>329, 13551, 2847, 25420, </team_members_id><team_members_names><![CDATA[Nikola Biliškov, Igor Dejanović, Irena Sović, Igor Milanović, ]]></team_members_names><keywords_hr><![CDATA[grafen, aerografit, mehanokemija, skladištenje energije, amidoborani metala, dihalkogenidi prijelaznih metala]]></keywords_hr><keywords_en><![CDATA[graphene, aerographite, mechanochemistry, energy storage, metal amidoboranes, transition metal dihalcogenides]]></keywords_en><summary_hr><![CDATA[Predloženi projekt se temelji na primjeni okolišno prihvatljivih mehanokemijskih metoda u priređivanju materijala u čvrstom stanju za upotrebu u pohrani energije. Fokus će biti na priređivanju glavnine grafena i aerografita (također poznatog kao grafenska spužva ili porozni ugljik), koji će biti funkcionaliziran dihalkogenidima prijelaznih metala (TMCD) i vodikom bogatim metalnim amidoboranima (MAB) za upotrebu npr. u baterijama, za cijepanje vode reakcijom razvoja vodika ili za pohranu vodika. Uspije li ovaj projekt, moći ćemo proizvoditi te materijale u većim količinama te se nadamo da ćemo time doprinjeti napretku hrvatske akademske zajednice, kao i industrije, u svrhu ostvarenja moguće primjene tih materijala na polju elektronike, pohrane energije, baterija, kondenzatora, u katalizi, pročišćavanju, spremnicima vodika, pohrani vodika itd. Očekivani ishod su nove čiste procedure priređivanja glavnine grafena, TMCD-a i MAB-a u čvrstom stanju. Dodatno, razumijevanje mehanizama tih procesa bit će omogućeno in-situ praćenjem mehanokemijskih reakcija. Na kraju, s obzirom na to da porozni materijali omogućuju nanodimenzionalnost čestica MAB-a, bit će priređen impregnirani aerografit te će biti karakteriziran s obzirom na svojstva relavantna za upotrebu u pohrani vodika. Očekujemo da će kombinirani pristup rezultirati značajno unaprijeđenim performansama priređenih MAB-a s obzirom na pohranu vodika. ]]></summary_hr><summary_en><![CDATA[This project proposes to apply environmentally friendly mechanochemical methods for the preparation of solid-state materials for energy-storage applications. The focus will be on the preparation of bulk graphene and aerographite (also known as grahene sponge or porous carbon) which will be funcionalised by transition metal dihalcogenides (TMDC) and hydrogen-rich metal amidoboranes (MAB) for the use e.g. in bateries, water splitting by hydrogen evolution reaction or for hydrogen storage. With the success of this project, we will be able to produce these materials in larger quantities and we hope to further the Croatian academic community as well as industry which are intended to use them to pursue possible applications in the fields of sorption, electronics, batteries, capacitors, catalysis, purification, hydogen fuel tanks, hydrogen storage etc. The expected outcome are novel clean procedures for solid-state preparation of bulk graphene, TMDCs  and MABs.  Additionally, mechanistic understanding of these processes will be provided by in-situ monitoring of mechanochemical reactions. Finally, since porous materials enable nanodimensionality of MAB particles, impregnated aerographite will be prepared and characterized with respect of the use in hydrogen storage applications. It is very probable that this combined approach would result in a considerably improved hydrogen storage performance of prepared MABs.]]></summary_en></project><project>
<id>4649</id><title_hr><![CDATA[Procjena potencijala jadranskih algi za ko-generacijsku proizvodnju biogoriva 3. generacije]]></title_hr><title_en><![CDATA[Assessment of Adriatic Algae Potential in Co-generation Production of 3rd. Generation Biofuel]]></title_en><user_id>533</user_id><user_firstLast_name>Maria Blažina</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>PKP</proposal_type><proposal_call>2016-06</proposal_call><code>PKP-2016-06-9081</code><acronim><![CDATA[A3-PICO-3G]]></acronim><duration>01.04.2017 - 31.03.2019</duration><status>Završio</status><financ_value>265.445,62 eur</financ_value><scie_area_hr>Biotehničke znanosti, Prirodne znanosti, </scie_area_hr><scie_area_en>Biotechnical sciences, Natural sciences, </scie_area_en><scie_field_hr>Biotehnologija, Biologija, Kemijsko inženjerstvo, </scie_field_hr><scie_field_en>Biotechnology, Biology, Chemical engineering, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>467, 20455, 20041, 20497, 4898, 5839, 20488, 451, 20392, 20473, 5520, 318, 23222, 23207, 2911, </team_members_id><team_members_names><![CDATA[Tamara Đakovac, Marko Mužic, Zoran Ereš, Darko Ferenčević, Tarzan Legović, sonja nikolić, Erik Muller, Jelena Godrijan, Lana Magić, Biserka Lukarić Špalj, Tin Klanjscek, Tina Šilović, Andrea Budiša, Ines Haberle, Enis Hrustić, ]]></team_members_names><keywords_hr><![CDATA[biomasa, biogoriva, lipidi, ugljikohidrati, fotobioreaktor, otpadne vode]]></keywords_hr><keywords_en><![CDATA[biomass, biofuels, microalgae, lipids, carbohydrates, photobioreactors, wastewaters]]></keywords_en><summary_hr><![CDATA[Zbog pozitivnog utjecaja na okoliš, postoji vrlo veliki interes za povezivanje sustava bioprerađivačkog uzgoja algi s postojećim industrijskim postrojenjima, kao što su rafinerije nafte i postrojenja za obradu otpadnih voda. U ovom znanstvenom projektu biti će razvijena pouzdana baza za bioprospecting mikroalgi sjevernog Jadrana na temelju numeričkih modela i empirijskih podataka. Ona će se koristiti za daljnji razvoj 3. generacije biogoriva u INA-rafineriji nafte u Urinju. Istražit će se metodologija za odabir najprikladnijih autohtonih vrsta mikroalgi u sjevernom Jadranu i povezanih heterotrofnih bakterija za proizvodnju biorafinerijske sirovine. Potencijal jadranskih mikroalgi za uzgoj ustvrdit će se odabirom različitih vrsta, na temelju (i) korištenja postojećeg znanja, (ii) predviđanja optimalnih uvjeta potrebnih za njihov rast putem numeričkih modela i (iii) eksperimentalne provjere u fotobioreaktoru pod različitim hranibdenim uvjetima. Modeli će biti razvijeni uzimajući u obzir karakteristike otpadnih voda (N, P hranjive tvari, organski C, temperatura i salinitet) te stehiometriju raznih vrsta. Projekcija mikroalgi će se usredotočiti na sljedeće kriterije: prinos biomase, proizvodnju lipida i ugljikohidrata, izdvajanje stanica i ekstrakciju ulja, C16, C18 i zasićenja masnih kiselina. Iskustva stečena u fazi validacije će predstavljati bazu za bioprospecting Jadrana u procesima bio-rafiniranja, omogućujući tako INA-rafineriji nafte poboljšanje postupka za pročišćavanje otpadnih voda kroz razvoj kogeneracije. Takva kogeneracija će imati pozitivan utjecaj na okoliš smanjenjem zagađenja i povećanjem učinkovitosti, kao i pozitivni gospodarski učinak smanjenjem troškova pročišćavanja voda te osigurati dodatnu zaradu od proizvodnje biomase.]]></summary_hr><summary_en><![CDATA[Because of the positive impact on environment, there is a rising interest in connecting boirefinery algal cultivation systems to existing industrial units, such as oil refineries, and wastewater treatment plants. Herein a scientifically reliable platform will be developed for the northern Adriatic microalgae bioprospecting, based on numerical model and empirical data. It will be used for further development of 3rd generation biofuel in INA-oil refinery in Urinj. The methodology for selection of the most suitable microalgae species indigenous to northern Adriatic and associated heterotrophic bacteria, will be explored for production of biorefinery feedstock. The potential of Adriatic microalgae for cultivation will be acquired through selection of candidate species, based on (i) the survey of existing knowledge, (ii) prediction of the optimum required growth conditions through numerical models and (iii) their experimental verification under various feeding-regimes of the photobioreactor. Models will be developed taking into account wastewater characteristics (N, P nutrients, organic C, temperature, salinity) and stoichiometry of the various species. Screening of microalgae will focus on following criteria: biomass yield, lipid and carbohydrate productivity, cells harvesting and oil extractability, C16, C18, and FA saturation. Lessons learned during validation phase will provide a platform for the Adriatic bioprospecting in biorefining processes, thus enabling INA-oil refinery to improve the wastewater cleanup procedure through co-generation development. Such co-generation would have a positive environmental impact by reducing pollution and increasing efficiency, as well as positive economic effect by reducing costs of water purification and providing added revenue from the biomass production.]]></summary_en></project><project>
<id>4650</id><title_hr><![CDATA[Izravna oporaba komunalne otpadne vode za navodnjavanje membranskim tehnologijama]]></title_hr><title_en><![CDATA[Direct reuse of municipal wastewater for agriculture irrigation with membrane technologies]]></title_en><user_id>20202</user_id><user_firstLast_name>Davor Dolar</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>PKP</proposal_type><proposal_call>2016-06</proposal_call><code>PKP-2016-06-8522</code><acronim><![CDATA[ReHOHMem]]></acronim><duration>01.04.2017 - 31.03.2019</duration><status>Završio</status><financ_value>198.143,04 eur</financ_value><scie_area_hr>Tehničke znanosti, Prirodne znanosti, </scie_area_hr><scie_area_en>Technological sciences, Natural sciences, </scie_area_en><scie_field_hr>Kemijsko inženjerstvo, Kemija, Temeljne tehničke znanosti, </scie_field_hr><scie_field_en>Chemical engineering, Chemistry, Basic engineering sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet kemijskog inženjerstva i tehnologije]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Chemical Engineering and Technology]]></institution_en><team_members_id>20206, 20261, 4216, 20232, 12557, 20234, 2711, 20409, 20229, 20269, 20233, </team_members_id><team_members_names><![CDATA[Krešimir Košutić, Marko Racar, Danijela Ašperger, Sanja Radman, Dario Omanović, Jasmin Pađan, Marinko Markić, ANA ŠPEHAR, Katarina Jambrošić, Nada Glumac, Natalija Kolenić, ]]></team_members_names><keywords_hr><![CDATA[komunalna otpadna voda, poljoprivreda, oporaba, navodnjavanje, ultrafiltracija, nanofiltracija, reverzna osmoza, membranski bioreaktor]]></keywords_hr><keywords_en><![CDATA[municipal wastewater, agriculture, reuse, irrigation, ultrafiltration, nanofiltration, reverse osmosis, membrane bioreactor]]></keywords_en><summary_hr><![CDATA[Industrijalizacija, porast ljudske populacije i klimatske promjene tri su ključna uzroka vezana uz globalni problem opskrbe vodom namijenjene za piće, te za industrijske i poljoprivredne potrebe. Hrvatska je relativno bogata vodom s procijenjenim kapacitetom pitke vode od oko 9.1 Mm3, no posljednjih godina klimatske promjene sve više dolaze do izražaja kroz dugotrajna sušna razdoblja. Ovaj problem posebno se odnosi na poljoprivredni sektor, pri čemu su prinosi poljoprivrednih kultura i sigurnost opskrbe hranom postali nestabilni i ugroženi. Klimatska predviđanja poručuju da budućnost nije puno svjetlija pa je nužno uvoditi napredne i održive tehnologije kojima će se u industrijskom mjerilu iskorištavati raspoloživi vodeni kapaciteti za prevladavanje uzroka krize.Membranske tehnologije spadaju u napredne i održive tehnologije obrade voda koje se snažno razvijaju i sve intenzivnije primjenjuju, ekonomski su opravdane, nisu destruktivne, učinkovito zadovoljavaju strogo propisane standarde, te su ekološki održive. Namjera je ispitati primjenu membranskih ekološki održivih tehnologija (MEOT) mikrofiltracije, ultrafiltracije, nanofiltracije i reverzne osmoze, te membranskog bioreaktora za oporabu (adekvatna obrada s ciljem ponovnog korištenja) komunalnih otpadnih voda i njihovu upotrebu u poljoprivredi.Tijekom projekta pratit će se značajan broj parametara uključujući patogene mikroorganizme, kemijska zagađivala (biorazgradljive organske tvari, makronutrijenti, mikronutrijenti, teški metali, anorganske soli, hormoni, itd.) i odabrane kategorije novih zagađivala određena Provedbenom odlukom komisije (EU) 2015/495.Cilj ovog projekta je pokazati mogućnost oporabe otpadnih voda komunalnog porijekla za potrebe navodnjavanja primjenom MEOT-a, povećati poljoprivrednu proizvodnju, kroz povećanu dostupnost vode integriranim i održivim korištenjem vodnih resursa. Oporabom otpadnih voda postiže se efekt smanjenja intenzivnog crpljenja površinskih i podzemnih voda namijenjenih piću.]]></summary_hr><summary_en><![CDATA[Industrialization, human population increase and climate change are three crucial factors related to global problems associated with drinking water supply for industrial and agricultural purposes. Croatia is rich with water with estimated capacity around 9.1 Mm3, but over the last year’s climate changes are increasingly becoming pronounced through the long dry periods. This problem is particularly related to the agricultural sector and thus the yields of agricultural crops and food security have become unstable and vulnerable. Climate prediction points out that the future is not much brighter so it is necessary to implement advanced and sustainable technologies which will be able to use available water source to overcome the causes of the crisis.Membrane technologies belong to advanced and sustainable technologies of water treatment that are strongly developing, applying more intensively, economically are justified, are not destructive, effectively meet the strict prescribed standards and are environmentally sustainable. The intention is to investigate application of membrane ecologically sustainable technologies (MEST) microfiltration, ultrafiltration, nanofiltration, reverse osmosis, and membrane bioreactor for reuse of municipal wastewater for agriculture.During the project significant number of parameters will be monitored including pathogen microorganisms (bacterias, viruses), chemical contaminants (biodegradable organics, macronutrients, micronutrients, metals, inorganic salts, hormones, etc.) and selected emerging contaminants determined by Commission implementing decision (EU) 2015/495.The goal of this project is to show possibility of municipal wastewater reuse for agricultural irrigation using advance membrane technologies, increase agricultural production, through increased water availability with integrated and sustainable use of water sources. Reuse of wastewater helps to decrease over-abstraction of surface and groundwater used for drinking.]]></summary_en></project><project>
<id>4655</id><title_hr><![CDATA[Vinogradarstvo i klimatske promjene na području Hrvatske/]]></title_hr><title_en><![CDATA[VITiculture and CLImate Change in Croatia]]></title_en><user_id>11142</user_id><user_firstLast_name>Maja  Telišman Prtenjak</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>PKP</proposal_type><proposal_call>2016-06</proposal_call><code>PKP-2016-06-2975</code><acronim><![CDATA[VITCLIC]]></acronim><duration>03.04.2017 - 02.04.2019</duration><status>Završio</status><financ_value>224.308,18 eur</financ_value><scie_area_hr>Prirodne znanosti, Biotehničke znanosti, Društvene znanosti, </scie_area_hr><scie_area_en>Natural sciences, Biotechnical sciences, Social sciences, </scie_area_en><scie_field_hr>Geofizika, Poljoprivreda, Ekonomija, </scie_field_hr><scie_field_en>Geophysics, Agriculture, Economy, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>7643, 17750, 20393, 12576, 13543, 20276, 13508, 20366, 4418, 20281, 20318, 20130, 19366, 246, </team_members_id><team_members_names><![CDATA[Branko Grisogono, Andreina Belušić, Antun Marki, Marko Karoglan, Jasminka Karoglan Kontić, Mirela Osrečak Osrečak, Željko  Andabaka, Ivana Tomaz, Silvio  Šimon, Ivana Vladimira Petric, Renata Leder, IVAN PRŠA, Željka Kordej-De Villa, Maja Vehovec, ]]></team_members_names><keywords_hr><![CDATA[klimatske promjene, agroklimatski indeksi, tuča, fenologija vinove loze, defolijacija, fenolni sastav, analiza isplativosti meteoroloških usluga]]></keywords_hr><keywords_en><![CDATA[climate change, agroclimate indices, hail, grapevine phenology, leaf removal, phenolic composition, cost-benefit analysis of meteorological service]]></keywords_en><summary_hr><![CDATA[U Hrvatskoj se uočava trend porasta srednje godišnjetemperature zraka kao i velika varijabilnost u mjerenojekstremnoj oborini. Klimatološka istraživanja koja se provoderegionalnim klimatskim modelima pokazuju da će se ekstremnevrijednosti temperature i oborine iznad Europe intenzivirati ubudućoj klimi. Spomenute promjene temperature i oborine (aonda često i duboke konvekcije) imaju velik utjecaj navinogradarstvo, s obzirom da od svih živih organizama biljkeprve reagiraju na promjenu prizemne temperature. Promjenatemperature uslijed klimatskih promjena utjecat će: (i) različitona razvojne faze vinove loze u pojedinim vinorodnim područjimadiljem Hrvatske (tj. njihove fenološke karakteristike) te (ii)različito na različite sorte. Istovremeno povećanje temperaturemijenja raspodjelu konvektivne aktivnosti (oluje) time i pojavutuče koje su procijenjene kao drugi najveći uzrok materijalnihšteta u Hrvatskoj. Ujedno je uočen i trend povećanjaprosječnog trajanja padanja tuče na temelju postojećihmjerenja dobivenih u kopnenom dijelu Hrvatske. Zbognavedenog projekt ima nekoliko ciljeva. Na temelju dosadašnjihmeteoroloških podataka i arhivske građe analizirat će sesadašnje stanje te uspostaviti sustav praćenja ključnihfenoloških faza vinove loze uslijed klimatskih promjena. Namjeraje povezati dozrijevanje i kakvoću grožđa s agroklimatskimindeksima te odrediti povezanost parametara tuče sa stupnjemoštećenja vinove loze. Svrha je također omogućiti podrobnijuagronomsku i gospodarsku evaluaciju hrvatskih autohtonihsorata vinove loze u sadašnjoj i budućoj klimi. Ujedno će seodrediti (pomoću agroklimatskih indeksa) promjene u budućojklimi odnosno dat će se procjena povećanja ili smanjenjaodređenog tipa vremena u budućoj klimi koji pogoduju razvojutuče u Hrvatskoj. Pri tome će se ispitivati uspješnost pojedinihampelotehničkih mjera kako bi se bolje procijenila učinkovitostzahvata u cilju adaptacije vinogradarske tehnologije naklimatske promjene.]]></summary_hr><summary_en><![CDATA[in Croatia is observed the increasing trend in mean annual airtemperature and the large variability in the measured extremeprecipitation from prominent drought to severe flooding.Climatological studies based on regional climate models showthe intensification of the extreme values of temperature andprecipitation over Europe in the future climate. These changes intemperature and precipitation have a great impact onviticulture, considering that of all living organisms, plants reactfirst to the change of surface temperature. Due to climatechange, changes in temperature will affect: (i) differently alldevelopmental stages of vines in certain wine-growing areas inCroatia (i.e. their phenological characteristics) and (ii) differentlyon different varieties. At the same time, the temperatureincrease changes convective activity (storms) and thus theoccurrence of hail that are estimated as the second biggestcause of material damage in Croatia. The trend of increasingaverage duration of hailfall was also observed on the basis ofmeasurements obtained in the low land of Croatia. Due tomentioned, this project has several goals. Based onmeteorological and climatological datasets and wine andgrapevine archive data, the current situation and a monitoringsystem of key phenological phases of the vine due to climatechange will be analyzed and established. Furthermore, the aimis to link the ripening and quality of grapes with agroclimaticindices and determine the relationship between hail parametersand the degree of damages in grapevines. The purpose is alsoto enable: (i) detailed agronomic and economic evaluation forpreserving Croatian autochthonous grapevine varieties, (ii)determination of climate changes through agroclimatic indices indifferent future periods and (iii) an estimation of the increase ordecrease in certain weather types which favor convectivedevelopments (and hail).]]></summary_en></project><project>
<id>4658</id><title_hr><![CDATA[Procjena adaptabilnosti hrvatskog sortimenta kukuruza i soje u funkciji oplemenjivanja za tolerantnost na sušu]]></title_hr><title_en><![CDATA[Adaptability assessment of maize and soybean cultivars of Croatia in the function of breeding for drought tolerance]]></title_en><user_id>2923</user_id><user_firstLast_name>Ivan Pejić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>PKP</proposal_type><proposal_call>2016-06</proposal_call><code>PKP-2016-06-8290</code><acronim><![CDATA[AGRO-DROUGHT-ADAPT]]></acronim><duration>01.04.2017 - 31.03.2019</duration><status>Završio</status><financ_value>261.065,76 eur</financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Poljoprivreda, </scie_field_hr><scie_field_en>Agriculture, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Agronomski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Agriculture]]></institution_en><team_members_id>7754, 2976, 20437, 19290, 6287, 20433, 3305, 20429, 20417, 20416, 20418, 20451, 3893, 12605, 20440, 20444, 20431, 20445, 18945, 20410, 5091, 20419, 4812, 20408, 20499, 20481, 22835, 22833, 22834, 23526, 5364, 21410, </team_members_id><team_members_names><![CDATA[Hrvoje Šarčević, Maja Žulj Mihaljević, Snježana Kereša, Ana Lovrić, Jerko Gunjača, Marija Pecina, Domagoj Šimić, ALEKSANDRA SUDARIĆ, Ivica Buhiniček, Mirko Jukić, Domagoj  Stepinac, Krešo Pandžić, Nataša Strelec Mahović, Milan Mesić, Mirta Rastija, Dario Iljkić, Bojan Marković, Ivan Varnica, Sara Godena, Elvino Šetić, Gvozden Dumičić, Vesna Samobor, Antun Jambrović, Stipe Ivić, Davor Tomsic Tomsic, Tanja Likso, Snježana Čavlovićak, Marko Čajić, Saša Vuletić, Krešimir Đuretec, Renata Erhatić, Goran Jukić, ]]></team_members_names><keywords_hr><![CDATA[Suša, adaptabilnost, oplemenjivanje, selekcija, kukuruz, soja]]></keywords_hr><keywords_en><![CDATA[Drought, adaptability, breeding, selection, maize, soybean ]]></keywords_en><summary_hr><![CDATA[Od svih ekstremnih vremenskih nepogoda izazvanih klimatskim promjenama suša ima najveći ekonomski utjecaj na društvo (1). Suša je glavni i najčešći uzrok nerentabilnih prinosa najvažnijih poljoprivrednih kultura u RH (2). Prema globalnim i lokalnim scenarijima klimatskih promjena, u bližoj budućnosti se očekuju sve češće suše jačeg intenziteta (3), a što će utjecati na održivost proizvodnje najvažnijih poljoprivrednih kultura od strateške važnosti za RH.U dvije uzastopne godine ispitat će se genetska adaptabilnost najvažnijih i novih sorata kukuruza i soje u pogledu tolerantnosti na sušu radi identifikacije superiorne germplazme i metoda selekcije za potrebe oplemenjivanja. Konzorcij od 29 istraživača iz 9 partnerskih ustanova provest će poljske pokuse na 19 lokacija širom Hrvatske (kontinentalno i priobalno područje) s namjerom zahvaćanja „slučajne suše“ i procjene niza istih genotipova u različitim klimatskim scenarijima i njihove reakcije na optimalne i sušne uvjete. U svim pokusima će se analizirati faze rasta, razvoja i najvažnija agronomska svojstva pojedinih genotipova. Usporedno će biti provedena i laboratorijska fiziološka i molekularno-genetička ispitivanja radi „brze detekcije tolerantnih genotipova“, a ove metode će biti validirane sa stvarnim rezultatima iz poljskih pokusa. Na svim pokusnim lokacijama će biti prikupljani i analizirani mikrometeorološki podaci potrebni za procjenu pojave, intenziteta i trajanja suše.Naprednom statističkom analizom meteoroloških i bioloških podataka identificirat će se genotipovi kukuruza i soje koji najbolje podnose uvjete suše te metodika ispitivanja koja najbolje diskriminira takve genotipove, a što bi unaprijedilo proizvodnju i proces selekcije na ovo svojstvo u tekućim oplemenjivačkim programima (4). Detaljna analiza pokusnih i povijesnih klimatskih podataka iz redovnih meteoroloških mjerenja omogućit će preciznu procjenu stvarne ekonomske štete u poljoprivredi u Hrvatskoj, kao osnove za buduće razvojne politike.]]></summary_hr><summary_en><![CDATA[Among all extreme weather conditions caused by climate change, drought has the greatest economic impact on society (1). It is the main and the most common cause of unprofitable yields of most important agricultural crops in the Republic of Croatia (RH) (2). According to global and local climate change scenarios, more frequent and severe drought is expected in the near future (3), which will affect the sustainability of the most strategically important crops for RH.The genetic adaptability of the most important new varieties of maize and soybean will be examined in two consecutive years in terms of their drought tolerance to identify superior germplasm and selection methods for breeding purposes. A consortium of 29 researchers from 9 partner institutions will carry out field trials at 19 locations around Croatia (continental and coastal areas) to grasp &#39;&#39;random drought&#39;&#39; and evaluate selected genotypes in different climatic scenarios in order to assess their reactions to optimum and drought conditions, through different growth stages as reflected to the most important agronomic traits. Simultaneously, laboratory physiological and molecular genetic testing will be conducted for &#39;&#39;fast detection of tolerant genotypes&#39;&#39;, and validated with actual results from field trials. At all field locations micrometeorological data will be collected and analysed in order to estimate the appearance, intensity and duration of the drought.Advanced statistical analysis of meteorological and biological data will enable the identification of the best drought tolerant maize and soybean genotypes and the best discriminating testing methodology, which would improve the production and selection for this trait in the current breeding programs (4). A comprehensive analysis of the experimental and historical climate data from regular meteorological measurements will enable an accurate assessment of actual economic losses to agriculture in Croatia, as a basis for future developmental policies.]]></summary_en></project><project>
<id>4660</id><title_hr><![CDATA[Smanjenje emisija stakleničkih plinova upotrebom gradskog i poljoprivrednog otpada u proizvodnji bilja]]></title_hr><title_en><![CDATA[Reduction of greenhouse gas emissions through urban and agricultural waste utilization in plant production]]></title_en><user_id>6613</user_id><user_firstLast_name>Dean Ban</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>PKP</proposal_type><proposal_call>2016-06</proposal_call><code>PKP-2016-06-9041</code><acronim><![CDATA[REDGREENPLANT]]></acronim><duration>01.04.2017 - 31.03.2019</duration><status>Završio</status><financ_value>265.018,38 eur</financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Poljoprivreda, </scie_field_hr><scie_field_en>Agriculture, </scie_field_en><institution_hr><![CDATA[Institut za poljoprivredu i turizam]]></institution_hr><institution_en><![CDATA[Institute of Agriculture and Tourism in Poreč]]></institution_en><team_members_id>12403, 20413, 20387, 19017, 20472, 3037, 6861, 6108, 20438, 20523, 20521, 6490, 20475, 22828, 22830, 25256, 19688, </team_members_id><team_members_names><![CDATA[Igor Pasković, Marko Černe, Marija Romić, Aleksandra Perčin, Marina Diana Igrc, Igor Palčić, Milan Oplanić, Barbara Soldo, Vilim  Filipović, Josip Gugić, Ljudmila Benedik, Josipa Perković, Tea Zubin Ferri, Nikola Major Major, Danko Cvitan, Radojko Jaćimović, Zoran Užila, ]]></team_members_names><keywords_hr><![CDATA[kompost, biočar, piroliza, poljoprivreda, gnojivo]]></keywords_hr><keywords_en><![CDATA[compost, biochar, pyrolise, agriculture, fertilizer]]></keywords_en><summary_hr><![CDATA[Emisije stakleničkih plinova (SP) i klimatske promjene u jakoj su uzročno posljedičnoj vezi s poljoprivredom. Razlog tome je, što se iz poljoprivredne proizvodnje oslobađa značajna količina SP, a promjena klime utječe direktno na promjenu pogodnosti prostora za uzgoj poljoprivrednih vrsta bilja i životinja. Intenzivna se poljoprivreda, između ostalog, zasniva na velikoj potrošnji gnojiva, a njihova proizvodnja zahtjeva mnogo energije i stvara značajne emisije SP. Jedan od globalno prihvaćenih pristupa smanjenju emisija SP je smanjena upotreba mineralnih gnojiva, zamjenom za neki drugi oblik gnojiva. Gradski i poljoprivredni otpad koji neobrađen predstavlja ozbiljnu prijetnju zaštiti okoliša, obradom može postati kvalitetno gnojivo koje može zamijeniti mineralno. Naime, upotreba kompostiranog komunalnog mulja i maslinove komine, kao i upotreba biočara iz tih materijala, postaje sve zanimljivija zbog njihovog eventualnog pozitivnog utjecaja u obliku dodataka tlu, na strukturu i plodnosti tla, vraćanje hraniva u tlo te prinos. U mediteranskom području česti su tipovi tla s nedostatkom fosfora, te je gnojidba fosfornim gnojivima bitna za optimiziranje rasta usjeva. Istovremeno, organski otpad je često bogat fosforom, posebice komunalni mulj. Promatrajući utjecaj poljoprivrede na emisije SP i ograničenja koja postoje pri primjeni mineralnih gnojiva, ciljevi ovog projekta su istražiti upotrebu komunalnog mulja i komine u obliku komposta i biočara kao dodataka tlu sa svrhom povećanja plodnosti i smanjenja emisija SP u odnosu na primjenu mineralnih gnojiva. U ovom projektu istražit će se utjecaj navedenih dodataka tlu na fizikalna i kemijska svojstva te mikrobiološku aktivnost tla na primjeru crvenice i rendzine, rast i fiziologiju biljaka, usvajanje hraniva i toksičnih metala, te na kvalitetu i prinos istraživanih biljaka. Ciljevi predloženog projekta usmjereni na analizu postojećih i razvoj novih načina smanjenja emisija SP u poljoprivredi odgovaraju uvjetima natječaja.]]></summary_hr><summary_en><![CDATA[Greenhouse gas (GHG) emissions and climate changes are in strong causal relationship with agriculture. Agricultural production releases a significant amount of GHG, and at the same time climate changes affects directly the suitability of environment for plant and animal growing. Intensive agriculture is based on a large consumption of fertilizers and their production requires an ample energy and generates significant GHG emissions. One of the widely recognized approaches to reduce the GHG emissions is the reduced use of mineral fertilisers by their replacement with other forms of fertilizers. Untreated urban and agricultural waste represents a serious threat to environment; however after treatments could become a fertilizer that can replace the mineral one. The use of composted sewage sludge and olive pomace, and biochar derived from these wastes, as soil amendment, has been given an attention due to their positive effect on the soil structure, fertility, nutrient recycling, and yield. In Mediterranean area, P-low soils are widely present, and P fertilization is important strategy to optimize crop growth. At the same time, organic waste are often rich on P, particularly sludge waste. Considering the agricultural contribution to GHG emission and limitations in mineral fertilizers supply, the objectives of the project will focus on efficiency of sewage sludge and olive pomace as compost and biochar as soil amendments on increasing soil fertility and reducing GHG emissions compared to mineral fertilizers. The effect of waste amendments on physical and chemical properties and microbiological activity of terra rossa and rendzina soils, plant growth and physiological response, nutrients and toxic metals utilization, yield and quality of tested plant will be explored. The objectives of the proposed project are focused on analysis of existing application and development of new measures for reduction of GHG emissions in agriculture and they fulfil the goal of the call.]]></summary_en></project><project>
<id>4663</id><title_hr><![CDATA[Održivi koncept integracije distribuiranih spremnika energije]]></title_hr><title_en><![CDATA[Sustainable concept for integration of distributed energy storage systems]]></title_en><user_id>7001</user_id><user_firstLast_name>Tomislav Capuder</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>PKP</proposal_type><proposal_call>2016-06</proposal_call><code>PKP-2016-06-3190</code><acronim><![CDATA[SUCCESS]]></acronim><duration>01.04.2017 - 31.03.2019</duration><status>Završio</status><financ_value>126.790,10 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Elektrotehnika, Računarstvo, Strojarstvo, </scie_field_hr><scie_field_en>Electrical engineering, Computer sciences, Mechnical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id>20487, 20181, 904, 13621, 20291, 17618, 20482, 20524, 20476, 23193, 23194, </team_members_id><team_members_names><![CDATA[Ante Marušić, Vedran Bobanac, Tomislav Dragičević, Ivan Pavić, Hrvoje Bašić, Ivan Periša, Marko Brkljačić Brkljačić, Danijel Habijan, Slavko Krajcar, Mirna Gržanić, Tomislav Pavlović, ]]></team_members_names><keywords_hr><![CDATA[Fleksibilni distribucijski sustavi, Laboratorijska ispitivanja, Niskougljični energetski sustavi, Napredne energetske mreže, Spremnici energije]]></keywords_hr><keywords_en><![CDATA[Battery storage, Distribution system operation and planning, Energy markets, Flexible distribution systems, Laboratory testing, Low carbon systems]]></keywords_en><summary_hr><![CDATA[Gotovo sve energetske strategije potiču integraciju niskougljičnih tehnologija, bilo na strani proizvodnje bilo na strani kranjih potrošača, s ciljem smanjenja utjecaja energetskog sektora na klimatske promjene. Ove nove tehnologije donose i nove izazove, posebice u planiranju i vođenju energetskog sustava, s obzirom da ih karakterizira veća varijabilnost i nesigurnost u odnosu na „tradicionalni“ energetski sustav. Ukoliko želimo postići ciljeve smanjenja stakleničkih plinova, utjecaj ovih varijabilnosti i nesigurnost potrebno je minimizirati te maksimalno iskoristiti proizvodenu energiju iz obnovljivih izvora energije. Spremnike energije smatra se ključnim tehnologijama u razvoju budućih niskougljičnih energetskih sustava. Sposobnost spremnika da pruže usluge fleksibilnosti i smanje nesigurnost koji obnovljivi izvori energije unose u pogon elektroenergetskog sustava, čini ih izuzetno atraktivnom tehnologijom u tranziciji prema održivom energetskom sustavu. Instaliranjem spremnika blizu mjesta potrošnje koncept distribucijskih mreža, koje su tradicionalno pasivne mreže, znatno se mijenja. Uz to, uloga spremnika u budućem elektroenergetskom sustavu trebala bi biti višestruka; od povečanih mogućnosti upravljanja mrežom, smanjenja troškova pogona, povećanja sigurnosti opskrbe krajnjih kupaca pa do stabiliziranja cijena električne energije.U prvom dijelu projekta biti će provedena detaljna analiza regulatornih i tržišnih okvira u Europi i SAD-u s ciljem detektiranja najboljih praksi u razvoju distribucijskih sustava i tržišta.Drugi dio projekta biti će usmjeren na razvoj novih algoritama za vođenje i pogon distribucijskih sustava, pri čemu će tehnologije spremnika energije imati ključnu ulogu u pružanju usluga fleksibilnosti i operatoru sustava, ali krajnjem korisniku.U završnom, trećem, dijelu biti će razvijeno laboratorijsko okruženje za ispitivanje mogućnosti baterijskih sustava da pruže tražene usluge fleksibilnosti, definirane u drugom dijelu projekta.]]></summary_hr><summary_en><![CDATA[A number of energy strategies today encourage the integration of low carbon technologies at both the generation side and the consumer side with the goal of reducing the impact of the energy sector on climate change. These new technologies are creating challenges in operation and development of the power system due to their more uncertain and variable behaviour compared to “traditional” power systems. To achieve the goals of reducing the greenhouse gas emissions these uncertainties and variabilities need to be minimized, utilizing the production from renewable sources as much as possible.Energy storage is seen as one of key technologies in enabling the development of the low-carbon electricity system. By providing flexibility and alleviating the intermittent nature of renewable, energy storage has the potential to bridge the gap towards highly sustainable renewable energy systems. These units are expected to be placed closer to the place of consumption. This means that the distribution grid, which has traditionally been a passive network, will go through significant changes.The role of storage in future all electric systems should be multiple; from improving the management of distribution networks, reducing costs, improving the security and efficiency of electricity distribution network to stabilising market prices for electricity.In the first part of the project we will conduct a detailed analysis of the regulatory and market framework in EU and USA with the goal of detecting best practices in development of distribution systems and markets.Second part of the projects will focus on developing novel algorithms for planning and operating the distribution system, where technologies such as battery storage play a crucial role in providing flexibility services to both the final users and network operator.In the third and last part of the project we will focus on testing the capabilities of batteries to provide multiple services defined in the second part.]]></summary_en></project><project>
<id>4744</id><title_hr><![CDATA[Učinkovito bežično napajanje]]></title_hr><title_en><![CDATA[Efficient wireless power supply]]></title_en><user_id>5120</user_id><user_firstLast_name>Davor Vinko</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2017-05</proposal_call><code>UIP-2017-05-5373</code><acronim><![CDATA[EWPS]]></acronim><duration>01.03.2018 - 28.02.2023</duration><status>Završio</status><financ_value>230.935,42 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Elektrotehnika, </scie_field_hr><scie_field_en>Electrical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište Josipa Jurja Strossmayera Osijek, Fakultet elektrotehnike, računarstva i informacijskih tehnologija Osijek]]></institution_hr><institution_en><![CDATA[Josip Juraj Strossmayer University of Osijek, Faculty of Electrical Engineering, Computer Science and Information Technology Osijek]]></institution_en><team_members_id>22470, 24016, 24905, 29701, </team_members_id><team_members_names><![CDATA[Vanja  Mandrić Radivojević , Krešimir Grgić, Domagoj Bilandžija, Luka Filipović, ]]></team_members_names><keywords_hr><![CDATA[bežični prijenos energije, napajanje, učinkovitost, blisko polje, internet stvari]]></keywords_hr><keywords_en><![CDATA[wireless power transmission, power supply, efficiency, near field, internet of things]]></keywords_en><summary_hr><![CDATA[Mogućnost bežične komunikacije je standarna funkcionalnost modernih elektroničkih uređaja.  Od uređaja se očekuje mogućnost međusobnog povezivanja i razmjene podataka te istovremeno podržavanje različitih komunikacijskih tehnologija (WiFi, 3G, BlueTooth, GSM, ...). Sljedeći korak u daljnjem razvoju elektroničkih uređaja jest proširivanje bežične funkcionalnosti na napajanje uređaja. Moderni elektronički uređaji nude visoku razinu bežične povezivnosti, ali je napajanje uređaja (baterijsko ili spajanje na pojnu mrežu) ono što stoji na putu do potpune autonomije uređaja.    Projektni prijedlog obuhvaća istraživanje rezonantnog magnetskog bežičnog prijenosa energije, kroz koje bi se razvila tehnologija za učinkovito bežično napajanje elektroničkih uređaja. Unutar projekta elektronički su uređaji podijeljeni u dvije kategorije koje se bitno razlikuju prema potrošnji i potrebnom stupnju slobode položaja i autonomije. U prvoj kategoriji su uređaji vrlo niske potrošnje koji su dio IoT svijeta (npr. bežični senzorski čvorovi) i koji zahtijevaju visok stupanj slobode položaja. Druga kategorija su uređaji potrošnje od 1 W do 100 W (npr. gadgeti, prijenosna računala) kod kojih je potrebna značajno veća snaga. Cilj projektnog prijedloga je ostvariti učinkovito bežično napajanje u višekorisničkom okruženju, gdje jedan izvor (predajnik) bežično napaja više trošila (prijemnika).     Istraživanje unutar projekta će rezultirati definiranim okvirom za učinkovito bežično napajanje elektroničkih uređaja, prilagođeno vrsti i namjeni uređaja, s posebnim naglaskom na kompromis između potrošnje i autonomije.  ]]></summary_hr><summary_en><![CDATA[Wireless communication is standard functionality of modern electronic devices. It is expected that devices can interact and exchange data wirelessly by employing various communication technologies (WiFi, 3G, BlueTooth, GSM, ...). The next step in further development of electronic devices is to expand wireless functionality to the power supply of the device. Modern electronic devices offer a high level of wireless connectivity, but the power supply of the device (battery or power grid) stands on the way to fully autonomous devices.     The project proposal focuses on resonant magnetic wireless power transmission. Research aims to develop technology for efficient wireless power supply for electronic devices. Within the project, electronic devices are divided into two categories that differ significantly with respect to power consumption and required degree of freedom of position and autonomy. In the first category are electronic device with very low power consumption that are a part of IoT world (e.g. Wireless sensor nodes). They require a high degree of freedom of movement. In the second category are electronic devices whose power consumption is in the range from 1 W to 100 W (e.g. gadgets, laptops). They have significantly higher power demand. The objective of the project proposal is to develop efficient wireless power supply in a multi-user environment, where one power source (transmitter) can wirelessly supply more devices (receivers).       The research within the project will result in a defined framework for the efficient wireless power supply, adapted to the type and the purpose of the device, with emphasis on a compromise between device consumption and autonomy.]]></summary_en></project><project>
<id>4748</id><title_hr><![CDATA[Formalno rasuđivanje i semantike]]></title_hr><title_en><![CDATA[Formal reasoning and semantics]]></title_en><user_id>21409</user_id><user_firstLast_name>Tin Perkov</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2017-05</proposal_call><code>UIP-2017-05-9219</code><acronim><![CDATA[FORMALS]]></acronim><duration>01.12.2017 - 30.11.2022</duration><status>Završio</status><financ_value>148.981,35 eur</financ_value><scie_area_hr>Prirodne znanosti, Tehničke znanosti, Društvene znanosti, </scie_area_hr><scie_area_en>Natural sciences, Technological sciences, Social sciences, </scie_area_en><scie_field_hr>Matematika, Računarstvo, Informacijske znanosti, Kognitivna znanost, </scie_field_hr><scie_field_en>Mathematics, Computer sciences, Information sciences, Cognitive science, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Učiteljski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Teacher Education]]></institution_en><team_members_id>12963, 21430, 22496, 12516, 4388, 24024, 23890, 25905, 858383, 7040, 865424, 865425, </team_members_id><team_members_names><![CDATA[Tajana Ban Kirigin, Luka Mikec, Aleksandar Hatzivelkos, Marcel Maretić, Benedikt Perak, Branimir Stojanović, Sebastijan Horvat, Mandi Orlić Bachler, Tin Adlešić, Nikolina Filipović, Teo Šestak, Stipe Marić Marić, ]]></team_members_names><keywords_hr><![CDATA[matematička logika, modalna logika, teorija modela, logika u računarstvu, formalno rasuđivanje]]></keywords_hr><keywords_en><![CDATA[mathematical logic, modal logic, model theory, logic in computer science, formal reasoning]]></keywords_en><summary_hr><![CDATA[Projekt će uspostaviti novu istraživačku grupu u području matematičke logike, s ciljem uspostave suradnje među istraživačima čiji dosadašnji rezultati su pretežno teorijski s istraživačima koji su se u dosadašnjem znanstvenom radu fokusirali na primjene. Stoga je naglasak projekta na međusobnoj komunikaciji i diseminaciji, kao i usavršavanju doktoranada koji će se od samog početka znanstvene karijere poticati da razviju ovaj interdisciplinarni pogled. Sadržajno, cilj projekta je međusobno obogaćivanje teorijske i primijenjene logike s naglaskom na primjene logike u računarstvu, ali i obratno, primjene računalnih alata u logičkom i matematičkom istraživanju. Drugi cilj je primjena logike u konkretnim problemima lingvistike ili, općenitije, kognitivnih i informacijskih znanosti, pa i interdisciplinarnih područja u kojima se preklapaju ekonomija i matematika (teorija igara, teorija društvenog izbora). Na prvi pogled vrlo formalna i teorijska disciplina, logika je izrazito primjenjiva, a iznenađuje primjena istih ili sličnih logičkih sistema, osobito modalne logike, u vrlo različitim područjima. Formalizacija donosi pojmovnu preciznost i jasnoću, što omogućuje sigurnost u dokazivanju novih spoznaja, ali i rasvjetljuje kompleksnost problema i otkriva nova pitanja koja u neformalnom rasuđivanju mogu ostati skrivena. Teorijski aspekti projekta obuhvaćaju: 1) istraživanje izražajne snage formalnih jezika metodama teorije modela, 2) adekvatnost i potpunost, odlučivost i složenost logičkih sistema, osobito modalne logike, 3) istraživanje mogućnosti razvoja apstraktne teorije formalnih semantika. Aspekti primjene su: 1) razvoj, istraživanje i formalizacija matematičkih modela za probleme drugih disciplina, 2) razvoj i implementacija algoritama, 3) otkrivanje veza među pitanjima iz prividno različitih područja preko srodnih formalizacija. Projekt predviđa interdisciplinarnu i međunarodnu suradnju.]]></summary_hr><summary_en><![CDATA[A new research group in mathematical logic will be established, with the aim of collaboration between researchers whose previous results were mainly in pure logic and those who previously focused on applications. The emphasis of the project is on mutual communication and dissemination, and training of doctoral students who will be encouraged to develop this interdisciplinary approach from the very beginning of their career. The goal of the project is mutual enrichment of pure and applied logic, with emphasis on applications of logic in computer science, and vice versa, the application of computational tools in logical and mathematical research. Another goal is to apply logic to specific problems of linguistics or, more generally, cognitive and information sciences, as well as interdisciplinary areas in which economics and mathematics overlap (game theory, social choice theory). Even though logic is at the first glance a formal and theoretical discipline, logic is also exceptionally applicable, and it is surprising to see applications of the same or similar formal systems, especially modal logics, in a variety of areas. Formalization brings conceptual precision, clarity and confidence. Formalization also provides new insights of the complexity of problems and allows for discovery of new issues that remain hidden in informal reasoning. The theoretical aspects of the project include: 1) exploring the expressive power of formal languages by methods of model theory, 2) soundness and completeness, decidability and complexity of formal systems, especially modal logics, 3) exploring the possibilities of developing an abstract theory of formal semantics. Application aspects are: 1) development, research and formalization of mathematical models for problems of other disciplines, 2) development and implementation of algorithms, 3) detection of links between seemingly unrelated domains through related formalizations. Interdisciplinary and international collaboration is planned.]]></summary_en></project><project>
<id>4755</id><title_hr><![CDATA[Korisniku orijentiran (re)dizajn procesa i  modeliranje informacijskih sustava  na primjeru smart city usluga]]></title_hr><title_en><![CDATA[User-oriented process (re)design and information systems modelling – a case of smart city services]]></title_en><user_id>121</user_id><user_firstLast_name>Maja Ćukušić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2017-05</proposal_call><code>UIP-2017-05-7625</code><acronim><![CDATA[MIS4SC]]></acronim><duration>01.01.2018 - 30.06.2023</duration><status>Završio</status><financ_value>129.186,85 eur</financ_value><scie_area_hr>Društvene znanosti, </scie_area_hr><scie_area_en>Social sciences, </scie_area_en><scie_field_hr>Ekonomija, Informacijske znanosti, </scie_field_hr><scie_field_en>Economy, Information sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Splitu, Ekonomski fakultet]]></institution_hr><institution_en><![CDATA[University of Split, Faculty of Economics, Business and Tourism]]></institution_en><team_members_id>6889, 22717, 13037, 25307, 12620, 864836, 6863, </team_members_id><team_members_names><![CDATA[Mario Jadrić, Dino Pavlić, Tea Dragičević, Ivana Ninčević Pašalić, Vinko Muštra, Anton Manfreda, Tihomir Orehovački, ]]></team_members_names><keywords_hr><![CDATA[korisniku orijentiran (re) dizajn procesa, razvoj informacijskih sustava temeljen na podacima, smart city usluge, quadruple helix, prototipiranje IS-a]]></keywords_hr><keywords_en><![CDATA[user-oriented process (re)design, data driven development of information systems, smart city services, quadruple helix, informat. system prototyping]]></keywords_en><summary_hr><![CDATA[Projekt istraživačke grupe MIS4SC (Modelling information systems for smart city services) se fokusira na nekoliko povezanih područja koja se sva sadržajno odnose na informatizaciju poslovnih procesa. Ukratko – fokus istraživanja je korisniku orijentiran (re)dizajn procesa i razvoj povezanih, modernih informacijskih sustava baziranih na pametnim tehnologijama. Razvijeni koncepti i modeli će se testirati na konkretnim problemima i to u domeni servisa/rješenja za pametne gradove. Iz tog razloga, projektnim prijedlogom je predviđeno uključivanje svih relevantnih dionika prema quadruple helix modelu. Od rezultata se očekuju nove metodologije i modeli primjenjivi u privatnom i javnom sektoru, među kojima: metodologija za korisniku orijentiran (re)dizajn procesa, okvir za modeliranje informacijskih sustava temeljen na podacima korisnika (data driven developement) te provjereni modeli G2C/C2G smart city usluga spremni za implementaciju. Kao rezultat projekta očekuje se i povećanje znanja i kompetencija o istraživanju i provođenju korisniku orijentiranih pristupa unutar grupe i šire. Kao očekivani doprinos projekta, među ostalim, ističu se: (1)	Inovacije u praksama planiranja i modeliranja korisniku orijentiranih informacijskih sustava, (2)	Aktivna participacija i povećano zadovoljstvo korisnika informacijskih sustava (bilo u privatnom ili javnom sektoru),(3)	Partnerstvo u istraživanju i razvoju vezanom uz društvene izazove smart city koncepta, (4)	Poboljšanje kvalitete, učinkovitosti i prihvaćanja javnih usluga u G2C/C2G okruženju.]]></summary_hr><summary_en><![CDATA[The project of the research group MIS4SC (Modelling information systems for smart city services) focuses on a number of related areas in business process informatization / automation domain. In short - the research focuses on process (re)design and the development of modern information systems based on smart technologies. The concepts and the models developed within the framework of the project will be validated in a specific context - services/solutions for smart cities. For this reason, the project proposal foresees the inclusion of all relevant stakeholders in the four-tier helix model.As for the results, new methodologies and models applicable in the private and public sectors are expected, including: the methodology for user-oriented process (re)design, the framework for data-driven information system modelling and the development and validation of a number of G2C/C2G smart city models/services ready for deployment. As for the outcomes, among other things, the following could be expected:(1) Innovations in the planning and modelling practices of user-oriented, data-driven information systems,(2) Active participation and increased satisfaction of users of information systems (whether in the private or public sector),(3) Research and development partnerships tackling social challenges of the smart city concept,(4) Improving the quality, efficiency and acceptance of public services in the G2C / C2G environment.]]></summary_en></project><project>
<id>4763</id><title_hr><![CDATA[Nanostrukturirani tvrdi metali - Novi izazovi metalurgije praha]]></title_hr><title_en><![CDATA[Nanostructured  hardmetals - New challenges for Powder Metallurgy]]></title_en><user_id>4702</user_id><user_firstLast_name>Tamara Aleksandrov Fabijanić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2017-05</proposal_call><code>UIP-2017-05-6538</code><acronim><![CDATA[NANO-PM]]></acronim><duration>15.05.2018 - 28.03.2023</duration><status>Završio</status><financ_value>308.950,20 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Metalurgija, Kemijsko inženjerstvo, Strojarstvo, </scie_field_hr><scie_field_en>Metallurgy, Chemical engineering, Mechnical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet strojarstva i brodogradnje]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Mechanical Engineering and Naval Architecture]]></institution_en><team_members_id>7321, 5210, 22741, 24281, 855836, </team_members_id><team_members_names><![CDATA[Mateja Šnajdar Musa, Ivan Kumić, Marin Kurtela, Vedran Šimunović, Zoran Tomić Tomić, ]]></team_members_names><keywords_hr><![CDATA[metalurgija praha, nanosturkturirani tvrdi metali, nano prahovi, alternativna veziva, korozijska postojanost, PACVD ]]></keywords_hr><keywords_en><![CDATA[powder metallurgy, nanostructured hardmetals, nano powder, alternative binders, corrosion resistance, PACVD process]]></keywords_en><summary_hr><![CDATA[Projekt predviđa razvoj, istraživanje i inženjerstvo površina nanostrukturiranih tvrdih metala. Na početku projekta predviđa se zapošljavanje doktoranda i uspostava Laboratorija za metalurgiju praha čime se doprinosi jačanju kapaciteta prijavitelja. U Laboratoriju će se pripremati mješavine različitih polaznih karakteristika variranjem udjela i vrste matrice (Co, Ni, Fe..), karakteristika WC prahova i inhibitora rasta zrna (VC, NbC, TiC, TaC i Cr3C2) u cilju razvoja inovativnih nanostrukturiranih tvrdih metala s alternativnim vezivima i korozijski postojanih nanostrukturiranih tvrdih metala. Konsolidacija mješavina provest će se sinter-HIP postupkom i sinteriranjem plazmom na jednom od najznačajnih instituta u području istraživanja Fraunhoffer IKTS, Dresden, Njemačka. Istraživanje i analiza konsolidiranih uzoraka dovesti će do utvrđivanja utjecaja karakteristika polaznih mješavina i parametara konsolidacije na konačna svojstva nanostrukturiranih tvrdih metala. Nakon razvoja i detaljnog istraživanja predviđenih u prve tri godine projekta, u posljednje dvije godine istraživanja će se proširiti i na postupke prevlačenja nanostrukturiranih tvrdih metala. Prevlačenje će biti provedeno jednom od najsuvremenijih tehnologija inženjerstva površina, plazmom potpomognutog prevlačenja iz parne faze PACVD. Predviđa se nanošenje višeslojnih gradijentnih prevlaka kombinacijom slojeva TiN, TiCN i TiBN s ciljem postizanja inovativne prevlake poboljšanih svojstava na prethodno konsolidirane uzorke. Na temelju provedenih ispitivanja vrednovat će se provedeni postupak prevlačenja i optimirati parametri tehnološkog procesa. Donijet će se zaključi o primjenjivosti jedne od najsuvremenijih tehnologija inženjerstva površina, PACVD postupka, na nanostrukturirane tvrde metale. Predviđa se edukacija suradnika, sudjelovanje na konferencijama, objava znanstvenih radova u najutjecajnijim svjetskim časopisima, nabava kapitalne opreme te prijava projekta iz drugih izvora financiranja.  ]]></summary_hr><summary_en><![CDATA[The project predicts the development, research and surface engineering of nanostructured hardmetals. At the beginning of the project, the employment of Ph.D. student and the establishment of the Powder Metallurgy Laboratory is foreseen, thus contributing to the strengthening of the Faculty’s capacities. The mixtures would be prepared by varying the content and type of binder (Co, Ni, Fe ..), the characteristics of WC powders and grain growth inhibitors (VC, NbC, TiC, TaC and Cr3C2) in order to develop innovative nanostructured hardmetals with alternative binders and corrosion-resistant nanostructured hardmetals. The consolidation of the mixtures would be performed by sinter-HIP and plasma sintering process at Fraunhofer IKTS, Dresden, Germany, one of the most important institutes in the field. The research and analysis of the consolidated samples would be performed in order to determine the influence of starting mixture characteristics and consolidation parameters on the final properties. After the development and detailed research predicted in the first three years of the project, the research would be extended to the coating processes of nanostructured hardmetals in the last two years. Plasma assisted chemical vapor deposition PACVD, one of the most advanced surface engineering technologies, would be used. The multilayer gradient coatings by combination of TiN, TiCN and TiBN are planned for the purpose of creating an innovative coating with enhanced properties on previously consolidated samples.  On the basis of the carried research, the applied coating process will be evaluated and the process parameters would be optimized. The conclusions on the applicability of the PACVD process on the nanostructured hardmetals would be brought. Training of associates, conferences attending, publishing of scientific papers in the most influential world journals, procurement of capital equipment and submission of projects to other funding sources is predicted by the project.]]></summary_en></project><project>
<id>4765</id><title_hr><![CDATA[In silico i in vivo analiza transkriptoma stanične stijenke kvasca Saccharomyces cerevisiae i primjena dobivenih rezultata u konstrukciji novih biotehnoloških sojeva]]></title_hr><title_en><![CDATA[In silico and in vivo analysis of yeast Saccharomyces cerevisiae cell wall transcriptome and its application in construction of novel biotechnological strains]]></title_en><user_id>4377</user_id><user_firstLast_name>Igor Stuparevic</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2017-05</proposal_call><code>UIP-2017-05-4411</code><acronim><![CDATA[SCCWTRANS]]></acronim><duration>01.12.2017 - 31.05.2023</duration><status>Završio</status><financ_value>295.069,35 eur</financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Biotehnologija, Prehrambena tehnologija, </scie_field_hr><scie_field_en>Biotechnology, Food technology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prehrambeno-biotehnološki fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Food Technology and Biotechnology]]></institution_en><team_members_id>25073, 855426, </team_members_id><team_members_names><![CDATA[Ana Novačić, Nada Šupljika, ]]></team_members_names><keywords_hr><![CDATA[RNA, ncRNA, yeast, cell wall, transcriptome, Saccharomyces cerevisiae]]></keywords_hr><keywords_en><![CDATA[RNA, ncRNA, yeast, cell wall, transcriptome, Saccharomyces cerevisiae]]></keywords_en><summary_hr><![CDATA[Razvoj najnovijih tehnika sekvenciranja razotkrio je neočekivano veliku složenost transkriptoma eukariotskih stanica. Transkripcija koja se pojavljuje izvan definiranih genskih regija rezultira nastajanjem nekodirajućih RNA (ncRNA). Mi želimo ovim projektom rasvijetliti još uvijek podcjenjeni utjecaj i značaj ncRNA u regulaciji proteina staničnu stijenku kvasca Saccharomyces cerevisiae. Planiramo provesti bioinformatičku meta-analizu te in vivo analizu transkriptoma stanične stijenke kako bi prikupili informacije o transkriptima koji su potencijalno regulirani djelovanjem nekodirajućih RNA pri različitim uvjetima, različitim fazama rasta ili tijekom životnog ciklusa (mitoza i mejoza). Ovaj rad trebao bi rezultirati informacijama koje bi nam omogućile konstrukciju novih sojeva kvasca s izmjenjenim svojstvima stijenke, a što bi pak moglo unaprijediti brojne biotehnološke procese.]]></summary_hr><summary_en><![CDATA[Developments of deep sequencing techniques have unveiled an unexpected complexity of the eukaryotic transcriptome. Transcription occurring outside of annotated regions leads to the production of non-coding RNAs (ncRNAs). Here, we focus on an as yet underappreciated aspect of influence and significance of these ncRNAs to the cell wall of yeast Saccharomyces cerevisiae. We plan to conduct a bioinformatical meta-analysis and in vivo analysis of the cell wall transcriptome to gain knowledge about transcripts which are possibly regulated by non-coding RNAs under various conditions, different growth phases or along the life cycle (mitosis and meiosis). The outcome of this work should yield information that will enable us to construct novel yeast strains with modulated cell wall properties which could improve different biotechnological processes.   ]]></summary_en></project><project>
<id>4766</id><title_hr><![CDATA[ŽIVOT NA RIMSKOJ CESTI: komunikacije, trgovina i identiteti na rimskim cestama u Hrvatskoj od 1-8-.st.]]></title_hr><title_en><![CDATA[LIFE ON ROMAN ROAD: communications, trade and identities on Roman roads in Croatia from 1st – 8th CE ]]></title_en><user_id>2786</user_id><user_firstLast_name>Ivana Ožanić Roguljić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2017-05</proposal_call><code>UIP-2017-05-9768</code><acronim><![CDATA[LRR]]></acronim><duration>01.01.2018 - 30.04.2023</duration><status>Završio</status><financ_value>149.578,61 eur</financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Arheologija, </scie_field_hr><scie_field_en>Archeology, </scie_field_en><institution_hr><![CDATA[Institut za arheologiju]]></institution_hr><institution_en><![CDATA[Institute of Archaeology in Zagreb]]></institution_en><team_members_id>22570, 22553, 22568, 22573, 855859, </team_members_id><team_members_names><![CDATA[Pia  Šmalcelj Novaković, Anita Rapan Papeša, valentina mantovani, Angelina Raickovic Savic, Jere Drpić, ]]></team_members_names><keywords_hr><![CDATA[rimska cesta, rimska keramika, rimska provincija Panonija,  rimska provincija Dalmacija, Avari]]></keywords_hr><keywords_en><![CDATA[Roman road, Roman ceramics, Roman province of Pannonia, Roman province of Dalmatia, Avari]]></keywords_en><summary_hr><![CDATA[Ceste u rimsko doba bili su arterije samog Carstva. Povezivali su provincije i gradove, a bez njih Rimljani nisu mogli niti osvojiti niti zadržati se na područjima kojima su vladali. Oni su bili sredstvo za pomicanje vojnih dužnosnika, civila i prijevoz robe. Rimske ceste stvorile su poveznice po kojima je u razdobljima nakon propasti Carstva organiziran život i osnivanje različitih naselja. Inženjerske i geodetske vještine Rimljana pružile su temelj mnogim današnjim rutama. Život na nekim rimskim cestama nastavio se i nakon pada Carstva i nije prestao do danas. Glavni cilj projekta je interpretacija svakodnevnog života na rimskoj cesti, od početka rimske vlasti do razdoblja propasti, akulturacije i integracije novih identiteta. Ovaj projekt nudi priliku za novu perspektivu: kako se život razvija oko rimskih cesta i staze tijekom glavne upotrebe cesta i nakon što je završio? Fokus projekta biti će razdijeljen na dva gledišta: 1. Život na rimskim cestama i stazama u rimsko doba, s obzirom na regionalne razlike (Lika - cesta Žuta Lokva, istočna Slavonija - Cibalae - Mursa), 2. Život neposrednih nasljednika (otok Korčula - cesta oko rimskih, kasnoantičkih i bizantske Lumbarde) i neizravnih sljedbenika (populacija kasnog Avarskog stanovništva iz 3 mjesta oko Cibala u istočnoj Slavoniji, bivša rimska pokrajina Panonnia Sirmiensis), rimska kulture u post-rimskom svijetu. U LRR projektu rimske ceste će se proučavati kao osnovna arterija rimskog svijeta, ali i kao metafora uvođenja, prihvaćanja i života rimskog načina života. Nakon propasti rimskog svijeta rimske ceste predstavljaju metaforu baštine i tradicije onoga što je nekada bilo veliko carstvo.]]></summary_hr><summary_en><![CDATA[Roads in Roman time were the arteries of the Empire itself. They connected provinces and cities, and without them the Romans could not have conquered and held onto the territories they ruled. They were means of moving military officials, civilians and to transport goods. Roman roads gave excellent links for organizing life and establishing various settlements in periods after the collapse of the Empire. Engineering and surveying skills of the Romans provided the basis for many of today&#39;s routes. Life on some Roman roads continued after the fall of the Empire and has not stopped until today. The main objective of the project is an interpretation of everyday life on the Roman road, from the beginning of the Roman rule to the period of decline, acculturation and integration of new identities. This project offers a chance for a new perspective: how does the life develop around Roman roads and a path during the main usage of the roads and after it’s over? Focus of the project will have different viewpoints: 1.Life on the Roman roads and paths in Roman times, considering the regional differences (Lika region – Road station Žuta Lokva;  Eastern Slavonia – Cibalae – Mursa route) 2.Life of direct successors (island Korčula – road around Roman, late Roman and Byzantine Lumbarda) and indirect followers (Late Avar population from 3 sites around Cibalae in Eastern Slavonia, former Roman province Panonnia Sirmiensis) of Roman culture in post-Roman world. In LRR project Roman roads will be studied as basic artery of Roman world but also a as a metaphors of introducing, accepting and living the Roman way of life. After the decline of Roman world Roman roads represent the metaphors of heritage and tradition of what was once a huge Empire.]]></summary_en></project><project>
<id>4773</id><title_hr><![CDATA[Metode za interpretaciju medicinskih snimki za detaljnu analizu zdravlja srca]]></title_hr><title_en><![CDATA[Medical Image Interpretation Methods for a Detailed Heart Health Analysis]]></title_en><user_id>21436</user_id><user_firstLast_name>Irena Galić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2017-05</proposal_call><code>UIP-2017-05-4968</code><acronim><![CDATA[IMAGINEHEART]]></acronim><duration>01.03.2018 - 28.02.2023</duration><status>Završio</status><financ_value>151.703,76 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Računarstvo, </scie_field_hr><scie_field_en>Computer sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište Josipa Jurja Strossmayera Osijek, Fakultet elektrotehnike, računarstva i informacijskih tehnologija Osijek]]></institution_hr><institution_en><![CDATA[Josip Juraj Strossmayer University of Osijek, Faculty of Electrical Engineering, Computer Science and Information Technology Osijek]]></institution_en><team_members_id>22468, 22473, 22467, 22558, 24844, 856226, 865511, </team_members_id><team_members_names><![CDATA[Hrvoje Leventić, Krešimir Romić, Zdravko Krpić, Tomislav Galba, Marija Habijan, Marin Benčević, Dario Mužević, ]]></team_members_names><keywords_hr><![CDATA[srce, segmentacija, analiza slike, simulacija, vizualizacija, programska biblioteka otvorenog koda, višestruka analiza zdravlja]]></keywords_hr><keywords_en><![CDATA[heart, segmentation, image analysis, simulation, visualisation, open source library, multiple health analysis]]></keywords_en><summary_hr><![CDATA[Kardiovaskularne bolesti uzrokuju godišnje više od 40% svih smrti u Europskoj Uniji. Metode snimanja u medicinske svrhe nezaobilazne su za utvrđivanje stanja kardiovaskularnog zdravlja neke osobe, a najčešće metode su računalna tomografija (CT) i magnetska rezonanca (MRI). Interpretacija tako prikupljenih medicinskih slika izrazito je ovisna o metodama računalne obrade, a potrebna programska podrška često je vrlo skupa i vezana uz proizvođača pojedinog uređaja, što otežava pristup takvom softveru manjim bolnicama i istraživačima.Osnovni cilj ovog projekta je razviti nove metode za analizu kardiovaskularne slike koje će moći odrediti što je više moguće kardiovaskularnih kvantifikacija srca iz što je moguće manje slika kako bi se postigla višestruka analiza kardiovaskularnog zdravlja. Takva analiza postići će se utvrđivanjem uzročno posljedičnih veza između određenih kvantifikacija i njihove dokazane utjecaje na kardiovaskularno zdravlje. Primjer kvantifikacija koje se mogu koristiti su: geometrija i volumen srca, geometrija bitnih arterija, morfologija aurikula lijeve pretklijetke, tok krvi kroz aortu, analiza srčane popustljivosti te kvantizacija epikardijalne masti. Odstupanje od normalnih vrijednosti gotovo svake od ovih kvanfitikacija faktor je rizika u razvoju neke od srčanih bolesti. Prepoznavanjem takvih odstupanja na vrijeme omogućit će se prepoznavanje potencijalnih rizika za zdravlje pacijenta što predstavlja fundamentalno poboljšanje u dijagnostici i tretmanu pacijenata.Konačan rezultat projekta bit će programska biblioteka otvorenog koda za analizu kardiovaskularnih slika, koja će sadržavate metode za sve kvantifikacije razvijene tijekom projekta. Bit će objavljena pod BSD licencom što će omogućiti suradnju i s industrijom i s akademskom zajednicom te će omogućiti istraživačima jednostavniju validaciju rezultata jer trenutno većina postojećih metoda nije javno dostupna istraživačima.]]></summary_hr><summary_en><![CDATA[Cardiovascular diseases are the main causes of more than 40% of all deaths in the European Union. Medical imaging techniques are unavoidable tools in the assesment of patient&#39;s cardiovascular health with the most often used methods being Computed Tomography (CT) and Magnetic Resonance Imaging (MRI).Interpretation of medical images acquired using these techniques depends on available image processing methods. Software packages implementing such methods are often both very expensive and proprietary, which means that small hospitals and research groups have difficulties purchasing such software.The main goal of this project is to develop a new method for the analysis of cardiovascular images which will be able to determine as many cardiovascular quantifications as possible using the lowest possible number of images, which will enable multiple analysis of cardiovascular health. Such analysis will determine the relationship between different hearh quantifications and risk factors for the development of cardiovascular diseases. The examples of quantifications that will be used are heart geometry and volume, geometry of important arteries, LAA morphology, blood flow through aorta, heart compliance, epicardial fat, etc. A discrepancy from reference values of each of these quantifications is a risk factor in the development of some heart disease.The final result of the project will be an open source library for cardiovascular image processing containing implementations of all methods developed within the scope of the project. The developed open source library will be BSD licensed fostering future cooperation with both academia and industry.]]></summary_en></project><project>
<id>4779</id><title_hr><![CDATA[Strukturiran ekološki uzgoj primjenom autonomnih robota u staklenicima]]></title_hr><title_en><![CDATA[Structured Ecological CULtivation with Autonomous Robots in Indoor Agriculture]]></title_en><user_id>21420</user_id><user_firstLast_name>Matko Orsag</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2017-05</proposal_call><code>UIP-2017-05-4042</code><acronim><![CDATA[SPECULARIA]]></acronim><duration>01.06.2018 - 30.11.2023</duration><status>Završio</status><financ_value>238.224,91 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Elektrotehnika, Temeljne tehničke znanosti, </scie_field_hr><scie_field_en>Electrical engineering, Basic engineering sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id>22738, 24179, 24172, 22725, 858415, 24260, 866665, 865777, 865776, </team_members_id><team_members_names><![CDATA[Antun Ivanović Ivanović, Marsela Polić, Juraj Oršulić, Marko Car, Jelena Tabak, Bruno Marić, Dean Martinović, Milena Jenić, Dario Stuhne, ]]></team_members_names><keywords_hr><![CDATA[Robotski sustavi, Bespilotne letjelice, Mobilna robotika, Podatni sustavi, Nelinearno upravljanje, Planiranje putanje, Planiranje zadataka ]]></keywords_hr><keywords_en><![CDATA[Robotic systems, Unmanned aerial vehicles, Mobile robotics, Compliant systems, Nonlinear control, Path planning, Path planning ]]></keywords_en><summary_hr><![CDATA[Cilj ovog projektnog prijedloga jest uspostaviti istraživačku grupu pri Fakultetu elektrotehnike i računarstva Sveučilišta u Zagrebu s istraživačkim fokusom na dvije posebno aktualne grane robotskog istraživanja, podatne manipulacije i heterogenih robotskih sustava. Predložene teme su trenutno jedne od najvećih pokretača istraživanja u robotici, te su pronašle svoju primjenu u različitim granama, počevši od medicine i industrije, pa sve do svemirske robotike. Budući da su ambiciozni praktični problemi, često najbolji pokretači istraživanja, za testiranje predloženih algoritama i ispitivanje sustava predložen je interdisciplinarni scenarij primjene heterogenog robotskog sustava u staklenicima organske poljoprivrede. Predloženim projektom planira se zaposliti i usavršiti doktorand i poslijedoktorand, odnosno educirati više generacija studenata fakulteta kroz rad na projektu. Uspješan nastavak rada na predloženoj temi, predviđen je, uz potporu Inovacijskog Centra Nikola Tesla, razvojem grupe u dva smjera: temeljno istraživanje i industrijsko primjenjivo istraživanje. Interdisciplinarnost projekta očituje se kroz horizontalnu temu poljoprivrede, a osigurana je potporom tvrtke Agrivi koja će pružiti svoje znanje i iskustvo.]]></summary_hr><summary_en><![CDATA[The main goal of this proposal is to establish a research group capable of performing internationally relevant research in the field of compliant robot control and heterogeneous robotic system in general, within the University of Zagreb Faculty of Electrical Engineering and Computing. These emerging topics are one of the most powerful drivers of robotic research. They are applied to various fields of research, including medical, industrial and even space robotics. Because, often enough practical problems are the best drivers of research, the project proposes validating these robotics research topics, in a scenario involving a heterogeneous robotics system utilized to help farmers in indoor organic agriculture. Project aim to employ and educate a PhD student and a Postdoctoral researcher, as well as offer undergraduate students an opportunity to work and learn on cutting edge robotics problems. Proposed three stage development of the group, in both basic technology research and industrial application, through the help of Innovation Center Nikola Tesla, will make sure the group continues the develop after the proposed project has ended. Interdisciplinary characteristic of the proposal is manifested through the application to agriculture and supported by a Croatian ICT company Agrivi, specialized in agriculture.]]></summary_en></project><project>
<id>4785</id><title_hr><![CDATA[Osnivanje i razvoj Centra za strukturno i nelinearno makroekonomsko modeliranje (MacroHub)]]></title_hr><title_en><![CDATA[Formation and Development of the Centre for Structural and Non-Linear Macroeconomic Modelling (MacroHub)]]></title_en><user_id>3635</user_id><user_firstLast_name>Tomislav Globan</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2017-05</proposal_call><code>UIP-2017-05-6785</code><acronim><![CDATA[MACROHUB]]></acronim><duration>01.01.2018 - 31.12.2022</duration><status>Završio</status><financ_value>180.797,84 eur</financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Ekonomija, </scie_field_hr><scie_field_en>Economy, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Ekonomski fakultet u Zagrebu]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Economics and Business]]></institution_en><team_members_id>3729, 3914, 3747, 3957, 4460, 3801, 3909, 25269, </team_members_id><team_members_names><![CDATA[Ozana Nadoveza, Marija Beg, Vladimir Arčabić, Tomislav Sekur, Lucija Rogić Dumančić, Tamara Slišković, Irena Raguž Krištić, Marin Levaj, ]]></team_members_names><keywords_hr><![CDATA[makroekonomija, strukturno modeliranje, istraživački centar, nelinearni modeli, evaluacija ekonomskih politika]]></keywords_hr><keywords_en><![CDATA[macroeconomics, structural modelling, research center, non-linear models, policy evaluation]]></keywords_en><summary_hr><![CDATA[Svrha projekta je osnovati i dugoročno razvijati moderni istraživački Centar za strukturno i nelinearno makroekonomsko modeliranje, koji bi u okviru Ekonomskog fakulteta u Zagrebu djelovao kao neovisna istraživačka jedinica - MacroHub. Istraživače MacroHuba činilo bi osam doktora ekonomskih znanosti te jedan doktorand. Svrha projekta ispunit će se ostvarenjem glavnih znanstvenih projektnih ciljeva: a) unaprjeđenjem znanstvenog kapaciteta uspostavljene istraživačke grupe; b) povećanjem istraživačke produktivnosti grupe; c) povećanjem istraživačke vidljivosti grupe; d) jačanjem znanstvene i stručne suradnje s inozemnim istraživačima. Na svjetskoj razini može se primijetiti nekoliko važnih trendova u makroekonomiji, od kojih se posebno ističu sve češća upotreba nelinearnih modela u teorijskim i primijenjenim istraživanjima te tzv. data rich pristup koji iskorištava dostupnost mnogobrojnih podataka. Uspostavljena istraživačka grupa će se organizirati oko tri istraživačke cjeline koje su usklađene s ovim trendovima. Prvi istraživački pravac fokusirat će se na razvoj i unaprjeđenje metodologije u makroekonomskim istraživanjima temeljenim na strukturnom (state-space) i nelinearnom (threshold) modeliranju te na njihovu primjenu u empirijskim istraživanjima. Unutar ovog pravca u sklopu projekta organizirat će se svjetski relevantna konferencija Society for Nonlinear Dynamics and Econometrics (SNDE) te će se razviti baza modela kojima će se istraživači MacroHuba koristiti kod primijenjenih istraživanja. Prvi pravac  komplementaran je drugom istraživačkom pravcu, usmjerenom na evaluaciju ekonomskih politika. U sklopu projekta izgrađeni modeli omogućit će  znanstvene temelje za bolji odabir među alternativnim ekonomskim politikama kroz vrednovanje njihovih učinaka. Treći istraživački pravac usmjerio bi se na razvoj novih i unaprjeđenje postojećih visokofrekventnih indikatora koji na jednostavan i lako razumljiv način opisuju dinamiku ekonomskih trendova u Hrvatskoj. ]]></summary_hr><summary_en><![CDATA[The purpose of the project is to set up and develop the Centre for Structural and Non-Linear Macroeconomic Modelling, which would act as an independent research unit (MacroHub) within the Faculty of Economics and Business in Zagreb. MacroHub research team comprises eight researchers with PhDs in the field of economics and one PhD student. The purpose of the project will be fulfilled by achieving several main scientific objectives: a) improving the scientific capacity of the formed research group; b) increasing the research productivity of the group; c) increasing the public visibility of the research group; d) strengthening the scientific and expert cooperation with foreign researchers. Several important trends can be observed on the global scene of macroeconomic research - more frequent use of non-linear models in theoretical and empirical studies and the data rich approach that utilises the availability of large volumes of data (big data). The formed research group will be organised around three research axes that are compliant to aforementioned global trends. The first research axis will focus on methodological developments and improvements in macroeconomic research based on structural (state-space) and non-linear (threshold) modelling and their application in empirical studies. Within this axis the research group will organise the globally prestigious conference of the Society for Nonlinear Dynamics and Econometrics (SNDE) and will develop the model database used by the MacroHub researchers in empirical papers. The first axis is complementary to the second research axis, focused on economic policy evaluation. Models built within the project will lay the groundwork for better policy implementation and evaluation of its effects. The third research axis will focus on the development of new and the improvement of existing high-frequency indicators, which describe and explain the dynamics of economic trends in Croatia in an easy and comprehensible fashion.]]></summary_en></project><project>
<id>4791</id><title_hr><![CDATA[Unaprjeđenje planiranja i gospodarenja zelenom infrastrukturom kroz participativno mapiranje kulturnih usluga ekosustava]]></title_hr><title_en><![CDATA[Improving green infrastructure planning and management through participatory mapping of cultural ecosystem services]]></title_en><user_id>7421</user_id><user_firstLast_name>Silvija  Krajter Ostoić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2017-05</proposal_call><code>UIP-2017-05-1986</code><acronim><![CDATA[CULTUR-ES]]></acronim><duration>01.01.2018 - 31.12.2022</duration><status>Završio</status><financ_value>109.098,15 eur</financ_value><scie_area_hr>Biotehničke znanosti, Društvene znanosti, </scie_area_hr><scie_area_en>Biotechnical sciences, Social sciences, </scie_area_en><scie_field_hr>Šumarstvo, Sociologija, </scie_field_hr><scie_field_en>Forestry, Sociology, </scie_field_en><institution_hr><![CDATA[Hrvatski šumarski institut]]></institution_hr><institution_en><![CDATA[Croatian Forest Research Institute]]></institution_en><team_members_id>25104, 25107, </team_members_id><team_members_names><![CDATA[Martina Kičić, Ana Marija Marin, ]]></team_members_names><keywords_hr><![CDATA[zelena infrastruktura, percepcija građana, kulturne usluge ekosustava, participativno mapiranje, fokus grupe, upitnik, webGIS]]></keywords_hr><keywords_en><![CDATA[green infrastructure, citizen perception, cultural ecosystem services and disservices, participatory mapping, focus groups, survey, webGIS]]></keywords_en><summary_hr><![CDATA[Važnost zelene infrastrukture (ZI) za kvalitetu života u gradovima neprestano raste. Raste i broj ljudi koji žive u urbanim sredinama, pa ih je tako u Europi već sada tri četvrtine. ZI pruža brojne usluge ekosustava te ju je prepoznala i Europska komisija kao alat za prostorno planiranje koji je mnogostruko koristan za ispunjavanje ciljeva brojnih politika (prostornog planiranja, zaštite prirode i bioraznolikosti, prilagodbe na klimatske promjene i slično). Kulturne usluge ZI definiraju se prema Milenijskoj procjeni ekosustava kao „nematerijalne koristi ekosustava koje ljudima pružaju duhovno obogaćivanje, kognitivni razvoj, promišljanje, rekreacijske i estetske usluge“. Važnost istraživanja kulturnih usluga ekosustava ogleda se u činjenici da u Europi prevladavaju kulturni krajobrazi, a potražnja za njima u razvijenim zemljama sve više raste što će se nastaviti i u budućnosti. S druge strane u demokratskim društvima raste i potreba za većim uključivanjem javnosti u odlučivanje vezano za planiranje i gospodarenje ZI, dok izostanak javnosti često dovodi do otpora i protesta. Participativnim mapiranjem kulturnih usluga ZI prikupljaju se podatci o tome kako ljudi percipiraju ili koriste kulturne usluge ZI te je takva informacija korisna za daljnje prostorno planiranje i gospodarenje ZI. Cilj ovog projekta je na primjeru grada Zagreba identificirati, kvantificirati i mapirati kulturne usluge i štete na osnovu percepcije građana, otkriti što utječe na njihovu percepciju  te dati preporuke kako uključiti rezultate participativnog mapiranja u poboljšanje postojećeg sustava prostornog planiranja i gospodarenja ZI. U projektu će se koristiti kvalitativne i kvanititativne metode i alati (fokus grupe, upitnici, webGIS). Očekuje se da će projekt unaprijediti postojeća znanja o kulturnim uslugama i štetama od urbane ZI, naročito u smislu kvantificiranja neopipljivih koristi, ali i šteta, elemenata koji su često isključeni u dosadašnjim istraživanjima.]]></summary_hr><summary_en><![CDATA[With growing population in urban areas both globally and in Europe, importance of green infrastructure (GI) for quality of life is constantly increasing. GI provides various ecosystem services (ES) and is recognised by European Commission as a tool for achieving goals of various policies (spatial planning, nature and biodiversity conservation, climate change adaptation, etc.). According to the Millennium Ecosystem Assessment, cultural ES are defined as „the nonmaterial benefits people obtain from ecosystems through spiritual enrichment, cognitive development, reflection, recreation, and aesthetic experiences”. Importance of studying cultural ES is reflected in prevalence of cultural landscapes in Europe, demand for them is constantly increasing, and it will continue in future. On the other side, there is an increasing demand in democratic societies to include public in decision making with regard to planning and management of GI, while public exclusion from the process often leads to protests.  Participatory mapping of cultural ES collects data on how public perceive cultural ES from urban GI, which is useful input for future planning and management of urban GI. The goal of this project is to identify, quantify and map cultural ES and disservices from urban GI based on public perception, explore what affects the perception, and to give recommendation on how to include results of participatory mapping in current spatial planning and management of urban GI. Mix of qualitative and quantitative methods and tools will be used for that purpose (focus groups, survey, webGIS). The project will enhance knowledge on cultural ES and disservices from urban GI, especially in terms of quantification of non-material benefits, as well as disservices from GI since these are often excluded from research on cultural ES. ]]></summary_en></project><project>
<id>5790</id><title_hr><![CDATA[Razumijevanje popravka unakrsnog vezanja DNA-Protein in vivo koristeći zebricu kao istraživački model ]]></title_hr><title_en><![CDATA[Deciphering DNA-Protein Crosslink Repair in vivo using zebrafish model ]]></title_en><user_id>4272</user_id><user_firstLast_name>Marta Popović</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2017-05</proposal_call><code>UIP-2017-05-5258</code><acronim><![CDATA[DNAPRO]]></acronim><duration>01.02.2018 - 01.02.2023</duration><status>Završio</status><financ_value>246.997,15 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Biologija, </scie_field_hr><scie_field_en>Biology, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>1050, 25102, 27233, 29045, </team_members_id><team_members_names><![CDATA[Ivan Mihaljević, Christine Supina, Ivan Antičević, Cecile Otten, ]]></team_members_names><keywords_hr><![CDATA[DNA-protein unakrsna veza, DNA oštećenja, popravak DNA, in vivo, riba zebrica]]></keywords_hr><keywords_en><![CDATA[DNA-protein crosslink, DNA damage, DNA repair, in vivo, zebrafish]]></keywords_en><summary_hr><![CDATA[Unakrsna veza DNA-protein (eng. DNA-protein crosslink; DPC) je tip DNA oštećenja koje nastaje kao posljedica ireverzibilne kovalentne veze između DNA i proteina u prisutnosti endogenog ili egzogenog DPC inducirajućeg agensa. Endogeni DPC induceri su nusprodukti staničnog metabolizma poput oksidativnih radikala, aldehida i promjene u DNA strukturi, dok su primjeri egzogenih inducera ultraljubičasto i ionizirajuće zračenje te različiti kemijski agensi. DPC-i su česta DNA oštećenja i predstavljaju fizičku prepreku za sve DNA transakcije: replikaciju, transkripciju, rekombinaciju i popravak. Nemogućnost popravka DPC-ova uzrokuje genomsku nestabilnost i teške posljedice za organizam, uključujući preuranjeno starenje, neurodegenreaciju i pojavu tumora. Unatoč visokoj učestalosti pojave DPC-a, malo se zna o mehanizmu njihova popravka, jer se sve donedavno DPC popravak nije smatrao zasebnim mehanizom popravka DNA. Tijekom 2014. i 2016. god. nekoliko grupa je identificiralo nove stanične enzime, proteaze Wss1 i SPRTN, koje proteolizom DPC-a iniciraju njihov popravak. Otkriće proteolizno-ovisnog popravka DPC-a dovelo je do prepoznavanja DPC popravka kao zasebnog mehanizma popravka DNA oštećenja. Međutim, trenutno nije poznata regulacija cijelog mehanizma, niti je poznato koji drugi faktori sudjeluju u popravku, dok gotovo ništa nije poznato o mehanizmu DPC popravka in vivo. Stoga je glavni cilj predloženog projekta otkriti regulaciju puta popravka DPC-a in vivo koristeći ribu zebricu (Danio rerio) kao istraživački model. Koristit ćemo CRISPR/Cas9 gensku manipulaciju kako bi utišali ili mutirali gen(e) od interesa, a za koji pretpostavljamo da su uključeni u DPC popravak. Uloga pojedinih proteina (i njihovih kombinacija) u popravku DPC-a biti će analizirana nakon izolacije DPC-a iz transgeničnih embrija i odraslih jedinki zebrice. Također, konstruirati ćemo GFP reporter test sa transgenim ribama koji će omogućiti kvantifikaciju učinkovitosti DPC popravka in vivo. ]]></summary_hr><summary_en><![CDATA[A DNA-protein crosslink (DPC) is a type of DNA lesion where a protein becomes irreversibly covalently bound to DNA upon exposure to endogenous or exogenous crosslink inducers. Endogenous DPC inducers are products of normal cellular metabolism such as reactive oxygen species, aldehydes and DNA helical alterations, while exogenous inducers include UV light, ionizing radiation and various chemicals. DNA-protein crosslinks are one of the most common DNA lesions and present a physical blockage to all DNA transactions: replication, transcription, recombination and repair. If not repaired, DPCs cause genomic instability and adverse phenotypes in humans including premature aging, neurodegeneration and cancer. Despite the frequency and severe outcomes of DPC formation, DNA-protein crosslink repair (DPCR) has been sparsely studied, mostly because it has not been considered to be a separate DNA damage repair pathway until recently. In 2014 and 2016, several groups identified novel proteases, Wss1 and SPRTN, which initiate the removal of DPCs through the proteolytic digestion of crosslinked proteins. The discovery of proteolysis-coupled DPC repair lead to recognition of DPCR as a separate DNA damage repair pathway. However, we currently do not know how this pathway is orchestrated and which other factors are involved. Indeed, almost nothing is known of DPCR mechanisms in vivo. Therefore, within this project we aim to unravel the orchestration of the DPCR pathway in vivo using zebrafish as a well-characterized vertebrate model. We will use CRISPR/Cas9 gene manipulation tools to knock-out and mutate specific genes in zebrafish which we suspect are involved in DPC removal. The contribution of each protein (and their combinations) to DPCR will be quantified after DPC isolation from transgenic zebrafish embryos and adults. We will also generate a GFP reporter assay in transgenic fish which will enable the quantification of DPCR efficiency in vivo.]]></summary_en></project><project>
<id>5797</id><title_hr><![CDATA[Genotipska specifičnost pšenične trave (Triticum aestivum L.) visokonutritivnog prirodnog dodatka prehrani]]></title_hr><title_en><![CDATA[Genotype specificity of wheatgrass (Triticum aestivum L.) highly nutritional natural food supplement ]]></title_en><user_id>4574</user_id><user_firstLast_name>Andrijana Rebekić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2017-05</proposal_call><code>UIP-2017-05-4292</code><acronim><![CDATA[WHEAT4GRASS]]></acronim><duration>01.01.2018 - 31.12.2022</duration><status>Završio</status><financ_value>231.840,20 eur</financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Poljoprivreda, Biotehnologija, </scie_field_hr><scie_field_en>Agriculture, Biotechnology, </scie_field_en><institution_hr><![CDATA[Sveučilište Josipa Jurja Strossmayera u Osijeku, Fakultet agrobiotehničkih znanosti Osijek]]></institution_hr><institution_en><![CDATA[Josip Juraj Strossmayer University of Osijek, Faculty of Agrobiotechnical Sciences in Osijek]]></institution_en><team_members_id>22586, 1277, 22588, 22590, 25001, 25321, </team_members_id><team_members_names><![CDATA[Miroslav Lisjak, Katarina Mišković Špoljarić, Sunčica Guberac, vedran orkić, Sanja Grubišić, Marija Kristić, ]]></team_members_names><keywords_hr><![CDATA[pšenična trava, in vitro bioraspoloživost, antioksidacijska aktivnost, obogaćeni proizvod, biofortifikacija, nutraceutik]]></keywords_hr><keywords_en><![CDATA[wheatgrass, in vitro bioavailability, antioxidative activity, enriched food, biofortification]]></keywords_en><summary_hr><![CDATA[Podizanjem svijesti o važnosti zdrave prehrane sve je veća potražnja za funkcionalnom hranom. Najjednostavniji oblik funkcionalne hrane su namirnice koje prirodno imaju visok sadržaj tvari s pozitivim utjecajem na zdravlje ljudi. Takva namirnica je pšenična trava (Triticum aestivum L.) koja se u obliku svježeg soka ili praha koristi kao dodatak prehrani. Pšenična trava predstavlja mlade izdanke vrsta roda Triticum koji u velikim količinama sadrže klorofil, bioflavonoide, esencijalne aminokiseline, vitamine, minerale i antioksidante. Zbog svog sastava pšenična trava ima značajan pozitivna utjecaj na detoksikaciju organizma, jačanje imuniteta i cijeli niz akutnih oboljenja. Ciljevi predloženog istraživanja su (1) ispitati genotipsku specifičnost pšenične trave s obzirom na in vitro bioraspoloživost Zn, Fe, Se, Mn, Mg, Ca, K i Na, antioksidacijsku aktivnost te sadržaj kloroplastnih pigmenata, (2) ispitati utjecaj biofortifikacije cinkom i selenom na mineralni sastav, antioksidacijsku aktivnost i sadržaj kloroplasta, (3) izdvojiti genotipove pšenice za uzgoj pšenične trave koji će se moći preporučiti za direktnu uporabu kao dodatak prehrani, (4) ispitati antiproliferativni učinak ekstrakata pšenične trave na humanim tumorskim staničnim linijama. Ispitivanje genotipske specifičnosti provest će sa na 100 genotipova pšenice različitog podrijetla te će se izabrati genotipovi na kojima će se ispitivati utjecaj biofortifikacije selenom i cinkom na ispitivana svojstva pšenične trave. Antiproliferativni učinak ekstrakata pšenične trave ispitat će se na 5 humanih tumorskih staničnih linija. Predloženo istraživanje rezultirat će saznanjima značajnima hrvatskoj i međunarodnoj znanstvenoj zajednici, jer istraživanje pšenične trave ovakvog tipa i ovakvog obima još nije provedeno. Prema našim saznanjima, prva smo istraživačka skupina u Republici Hrvatskoj koje će se baviti istraživanjima na pšeničnoj travi.]]></summary_hr><summary_en><![CDATA[Raising awareness on the importance of healthy diet has increase demand for functional food. In their simplest form, functional food is a food that naturally possess substances that positively affect people&#39;s health. Wheatgrass (Triticum aestivum L.) is such food. Wheatgrass can be utilized as a dietary supplement in the form of fresh juice or powder made from young shoots of species of the genus Triticum. It contains chlorophyll, bioflavonoids, essential amino acids, vitamins, minerals and antioxidants in high quantities. Because of its composition, wheatgrass has a significant positive effect on detoxification of the body, strengthening of immunity and on a full range of acute illnesses. In the proposed study we will investigate (1) the genotype specificity of wheatgrass regarding the in vitro bioavailability of Zn, Fe, Se, Mn, Mg, Ca, K and Na, antioxidant activity and chloroplast pigment content, 2) the influence of zinc and selenium biofortification on mineral composition, antioxidant activity and content of chloroplast pigments; (3) select wheatgrass genotypes for cultivation and for recommendation for usage in the form of powder or fresh juice, (4) the antiproliferative effect of wheatgrass extracts on human tumor cell lines. A genotype specificity will be tested on a set of 100 wheat genotypes of different origin. Based on the results of genotype specificity testing, 10 genotypes will be selected for investigation of the effect of zinc and selenium biofortification on examined traits in wheatgrass. Investigation of the antiproliferative effect of wheat grass extracts will be performed on 5 human tumor cell lines. The proposed research will result in findings that are significant to the Croatian and international scientific community. Research of this type and this scope on wheatgrass has not been carried out yet. According to our knowledge, we are the first research group in the Republic of Croatia that will research nutraceutical properties of wheatgrass.]]></summary_en></project><project>
<id>5806</id><title_hr><![CDATA[Ars lignea: drvorezbarska umjetnička baština sjevernog Jadrana od 1300. do 1600. godine]]></title_hr><title_en><![CDATA[Ars lignea: the Woodcarving Art Heritage of the North Adriatic from 1300 until 1600]]></title_en><user_id>12940</user_id><user_firstLast_name>Barbara Španjol-Pandelo</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2017-05</proposal_call><code>UIP-2017-05-6356</code><acronim><![CDATA[ArsLigneAdriatica]]></acronim><duration>01.03.2018 - 28.02.2021</duration><status>Završio</status><financ_value>82.117,86 eur</financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Povijest umjetnosti, Povijest, Znanost o umjetnosti, </scie_field_hr><scie_field_en>Art history, History, Arts, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Filozofski fakultet u Rijeci]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Humanities and Social Sciences]]></institution_en><team_members_id>22693, 12968, 28176, 5555, </team_members_id><team_members_names><![CDATA[Saša Potočnjak, Petra Predoević Zadković, Kosana Jovanović, Matko Matija Marušić, ]]></team_members_names><keywords_hr><![CDATA[drvorezbarstvo, drvena skulptura, Kvarner, Istra, srednji vijek, renesansa]]></keywords_hr><keywords_en><![CDATA[woodcarving, wooden sculpture, Kvarner bay, Istria, Middle Ages, Renaissance]]></keywords_en><summary_hr><![CDATA[U razdoblju između 1300. i 1600. godine drvorezbari su imali važan udio u oblikovanju i razvoju umjetničke produkcije u Europi. no na prostoru sjevernog Jadrana njihova je uloga u povijesno-umjetničkim istraživanjima često bila zanemarena. Sačuvane umjetnine važan su dio sakralnih prostora i svjedoče nam o važnosti njihove uloge u crkvenim obredima. Promjene u liturgiji uvjetovali su nestanak značajnog dijela drvenih predmeta sakralne namjene, no dio baštine se ipak sačuvao. Zbog osjetljivog drvenog materijala sklonog propadanju, ali i zbog promjena estetike sačuvan je manji broj predmeta svjetovne namjene. Ipak, oni nam govore u prilog značaja drvorezbarstva u svakodnevnom životu, a mogu nam biti važan izvor podataka o brojnim drvorezbarskim radionicama koje su zadovoljavale potrebe stanovništva i u duhovnom i u svjetovnom životu. Osnovni cilj projekta je omogućiti nove spoznaje o drvorezbarstvu i drvorezbarima koji su djelovali na prostoru sjevernog Jadrana odnosno Kvarnera, kvarnerskih otoka i Istre u razdoblju od 1300. do 1600. godine. Većina građe gotovo je potpuno zanemarena te je istraživanje nužno kako bi se u cjelovitom katalogu objedinili svi podaci. Važan dio istraživanja bit će pozicioniranje djelatnosti kasnosrednjovjekovnih i renesansnih drvorezbara u širi kontekst europske umjetnosti, u prvom redu drvorezbarske djelatnosti ostvarene na prostoru Apeninskog poluotoka i Srednje Europe. Rezultat osnovnog cilja projektnog prijedloga je cjeloviti uvid, baziran na temeljnim istraživanjima, o drvorezbarstvu i drvorezbarima koji su djelovali na prostoru sjevernog Jadrana, kako bi se pridonijelo valorizaciji i boljem očuvanju i čuvanju drvene skulpture i namještaja obuhvaćenog u predloženom projektnom prijedlogu. Također, rezultat osnovnog cilja projektnog prijedloga je uspostavljena istraživačka grupa mladih istraživača koji će razvijati istraživačku metodologiju i promicati značaj drvorezbarske baštine radi njene zaštite i društvene valorizacije. ]]></summary_hr><summary_en><![CDATA[Between 1300 and 1600 woodcarvers played an important role in shaping and developing artistic production in Europe. However, in the area of the northern Adriatic their role in art historical research has often been neglected. The preserved works of art are an important part of the sacred spaces and testify the importance of their role in liturgy. However, changes in the liturgy caused the disappearance of a significant part of wooden objects, but part of the sacral heritage has been preserved. Due to the susceptibility of wooden material to decay, but also due to the aesthetics changes, not many secular objects have been preserved. Nevertheless, both sacral and secular works of art stress the significance of woodcarving in the everyday life. Also they are an important source of information on numerous woodcarving workshops that had produced works of art for sacral and secular life. The main objective of the project is to provide the new insights into woodcarvings and woodcarvers that have been working in the area of the northern Adriatic, i.e. Kvarner bay, Kvarner islands and Istria from 1300 to 1600. Most of the woodcarvings have been neglected and the research is necessary in order to include all data in one complete catalogue. An important part of the research will be to put the activities of late medieval and Renaissance woodcarvers in the context of European art, firstly of woodcarving activities carried out on the Apennine Peninsula and Central Europe. The result of the overall objective would be a complete insight on woodcarvings of the northern Adriatic in order to contribute to valorisation and better preservation of wooden sculptures and furniture. Also, the result would be the establishment of a research group of young researchers who will develop research methodology and promote the importance of woodcarving heritage in order to protect it and evaluate it.  ]]></summary_en></project><project>
<id>6810</id><title_hr><![CDATA[Otiskivanje, kvaliteta i uporabljivost podloga s ne-drvnim vlakancima]]></title_hr><title_en><![CDATA[Printability, quality and utilization of substrates with non-wood fibres]]></title_en><user_id>19535</user_id><user_firstLast_name>IRENA BATES</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2017-05</proposal_call><code>UIP-2017-05-2573</code><acronim><![CDATA[NWF prints quality]]></acronim><duration>08.01.2018 - 07.06.2023</duration><status>Završio</status><financ_value>119.529,88 eur</financ_value><scie_area_hr>Tehničke znanosti, Biotehničke znanosti, </scie_area_hr><scie_area_en>Technological sciences, Biotechnical sciences, </scie_area_en><scie_field_hr>Grafička tehnologija, Prehrambena tehnologija, </scie_field_hr><scie_field_en>Graphics technology, Food technology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Grafički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Graphic Arts]]></institution_en><team_members_id>22695, 22688, 19527, 19976, 25409, </team_members_id><team_members_names><![CDATA[Katja Petric Maretić, Maja  Rudolf, Ivana Plazonić, Mia Kurek, Valentina Radić Seleš, ]]></team_members_names><keywords_hr><![CDATA[tiskovnost, kvaliteta reprodukcije, boje, migracija, stabilnost, ne-drvna vlakanca, papir]]></keywords_hr><keywords_en><![CDATA[printability, quality of reproduction, inks, migation, resistance, non-wood fibres, paper]]></keywords_en><summary_hr><![CDATA[U papirnoj industriji najkorištenija sirovina su drvna celulozna vlakanca čija se dostupnost drastično smanjila zbog neracionalne eksploatacije šumskih površina. Istraživanja u ovom projektnom prijedlogu biti će usmjerena na procjenu mogućnosti korištenja vlakanaca slame žitarica u izradi inovativnih tiskovnih podloga te njihova uporabljivost za novi grafički proizvod. Slama žitarica kao alternativa drvnoj sirovini logično se nameće jer jeftin je i godišnje obnovljiv izvor vlakanaca. S obzirom na aktualnu problematiku nedostatka drvne sirovine i potrebe za novim izvorima vlakanaca načinit će se laboratorijski papiri s ne-drvnim vlakancima i otiskivati najzastupljenijim tehnikama tiska u cilju procjene njihove upotrebljivosti za određeni grafički proizvod. Fizikalno-kemijska svojstva boje ovisna su o različitim tehnikama tiska kako bi se postigla kvalitetna reprodukcija višebojne slike i teksta. Navedene tehnike tiska koriste drugačije boje prema viskoznosti, konzistenciji, ljepljivosti i koheziji stoga je potrebno ispitati i evaluirati prihvaćanje boje na načinjene laboratorijske papire kao i prihvaćanje boje na prethodno otisnutu boju. Mogućnost otiskivanja i uporabljivost papira s ne-drvnim vlakancima promatrat će se na laboratorijskim papirima nanošenjem najzastupljenijih konvencionalnih i modernih boja. Temeljem kvalitativnih parametara: penetracije i migracije boje u podlogu, zrnatosti i nejednoličnosti reprodukcije tonova, kvalitete reprodukcije tona cijan, magente, žute i crne boje, te prihvaćanja boje na prethodnu otisnutu boju i ukupne količine boje na tiskovnoj podlozi definirati će se mogućnost otiskivanja na laboratorijskim uzorcima papira. Dok će se upotrebljivost tih otiska definirati na temelju stabilnosti na kemijske agense, pritisak, temperaturu, vlagu i UV zračenje. Ostvarivanjem ovog projektnog prijedloga stvoriti će se novi grafički proizvod, koji će unaprijediti područje grafičke tehnologije pametnim iskorištenjem obnovljivih resursa.]]></summary_hr><summary_en><![CDATA[In the paper industry a cellulose fibres are the main raw material, which availability for utilization in the paper industry has been drastically reduced due to irrational exploitation of this natural resource. Assessing the possibility of using straw in form of the pulp for the production of innovative paper-based printing substrates and their usability for the new graphical product is the aim of this project proposal. The straw comparing to wood raw material is a logical alternative because it is a cheap and annually renewable source of fibres. Considering the lack of wood raw materials and the need for new fibre sources, laboratory produced papers will be made using different shares of straw pulp, which will be printed with the most widely used printing techniques in order to estimate their usability. Physical and chemical properties of inks depend on different printing techniques to achieve high quality reproduction. The aforementioned printing techniques use different inks in terms of their viscosity, consistency, adhesiveness and cohesion, therefore it is necessary to examine and assess the acceptance of inks on substrate as well as the ink trapping.The printability of papers containing non-wood fibres and the paper’s usability will be observed on laboratory produced papers by applying the most commonly used conventional and contemporary inks.Based on the qualitative parameters: the penetration and migration of printing ink into the substrate, graininess and mottling, the quality of the tone reproduction, trapping and the total amount of inks on the substrate will be defined as the possibility of printing on laboratory produced sheets. While the usability of these prints will be defined on the basis of stability in relation to chemical agents, pressure, temperature, humidity and UV radiation. By realizing this project proposal, a new graphical product will be created, which will advance the graphic technology with smart utilization of renewable resources. ]]></summary_en></project><project>
<id>6811</id><title_hr><![CDATA[HRVATSKI MONITOR NASILJA - Istraživanje pojavnih oblika, uzroka i procesuiranja delinkventnog nasilja s fokusom na zaštiti posebno ranjivih skupina žrtava]]></title_hr><title_en><![CDATA[CROATIAN VIOLENCE MONITOR - A Study of the Phenomenology, Etiology, and Prosecution of Delinquent Violence with Focus on Protecting Particularly Vulnerable Groups of Victims]]></title_en><user_id>21439</user_id><user_firstLast_name>Reana Bezic</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2017-05</proposal_call><code>UIP-2017-05-8876</code><acronim><![CDATA[CroViMo]]></acronim><duration>01.03.2018 - 31.12.2025</duration><status>Završio</status><financ_value>181.195,64 eur</financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Pravo, </scie_field_hr><scie_field_en>Law, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Pravni fakultet u Zagrebu]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Law]]></institution_en><team_members_id>21441, 6366, 22507, 22482, 6127, 22461, 21442, 25465, 23551, 17736, 4770, </team_members_id><team_members_names><![CDATA[Ruža Karlović, Goran Livazović, Pero Mihaljević, Marko Mrakovčić, Lucija Sokanović Sokanović, Petra Šprem, Igor Vuletić, Mirjana Kondor-Langer, Karlo Bojčić, Vedran Recher, Marija Baković, ]]></team_members_names><keywords_hr><![CDATA[kriminologija, nasilje, prevencija nasilja, ubojstvo, kibernetičko uznemiravanje, Hrvatska]]></keywords_hr><keywords_en><![CDATA[criminology, violence, violence prevention, homicide, cyber harassment, Croatia]]></keywords_en><summary_hr><![CDATA[Projekt CroViMo ima za cilj uspostavljanje multidisciplinarne grupe mladih znanstvenika koji će provoditi inovativna istraživanja nasilja u Hrvatskoj kroz svoj „Laboratorij za analizu nasilja“. Glavni cilj istraživanja je empirijsko i normativno snimiti te analizirati fenomenologiju, etiologiju i procesuiranje delinkventnog nasilja u Hrvatskoj, pri čemu će naglasak biti na posebno ranjivim skupinama žrtava sa svojim vrlo specifičnim i različitim potrebama zaštite od nasilja. Te posebno ranjive skupine uključuju: djecu; žene i djevojke; starije; manjine, strance, izbjeglice i migrante; osobe u institucionaliziranoj skrbi; osoblje rizičnih zanimanja; i LGBT. Za razliku od uobičajenog tzv. „mainstream“ istraživanja nasilja, koje se uglavnom fokusira na specifične (pod)vrste nasilja i/ili skupine žrtava izvan općeg konteksta delinkventnog nasilja, CroViMo će prvo provesti izvorno istraživanje ukupnog delinkventnog nasilja, prije no što se fokusira na njegove pojedine (pod)vrste. Ovaj holistički pristup temelji se na pretpostavci da proučavanje određene (pod)vrste nasilja, bez empirijskih podataka o općem nasilnom kontekstu dovodi do fragmentarnih, a potencijalno i iskrivljenih shvaćanja pojedinih promatranih (pod)vrsta nasilja. Glavni zadatak CroViMo biti će razviti i testirati novu inovativnu klasifikaciju delinkventnog nasilja, „autentični sustav klasifikacije nasilja”, koja neće podlijegati normativnim ograničenjima trenutnih klasifikacija, nego će biti usredotočena isključivo na sam fenomen nasilja. Takav sustav klasifikacije mogao bi označiti prekretnicu u području istraživanja nasilja. Ovaj ambiciozni plan rada, ukoliko bi bio uspješno proveden, trebao bi dugoročno osigurati razvoj projekta CroViMo u prepoznatljiv nacionalni, regionalni i europski „Laboratorij za analizu nasilja“, te privući daljnje nacionalne i međunarodne znanstvene suradnje i uspješne nove kolaborativne projektne prijave, s velikim potencijalom za prijenos znanstvenih spoznaja u praksu.]]></summary_hr><summary_en><![CDATA[The CroViMo project aims at setting up a multidisciplinary nationwide research group of young researchers for conducting innovative violence research in Croatia through its&#39; “Violence Research Lab”. The central research objective is to empirically and normatively capture and analyse the phenomenology, etiology, and prosecution of delinquent violence in Croatia, with special focus on particularly vulnerable groups of victims with their very specific and diverse needs for protection from violence. These particularly vulnerable groups include: children; women and girls; the elderly; minorities, foreigners, refugees and migrants; persons in institutional custody; risky professions’ personnel; and LGBT. In contrast to ‘mainstream’ violence research, which predominantly focuses on specific (sub)types of violence and/or victim groups outside the overall context of general delinquent violence, CroViMo will conduct genuine foundational research on the total of delinquent violence, before focusing on its’ certain (sub)types. This broad approach is based on the premise that the study of certain (sub)types of violence without empirical data on the overall violent context leads to fragmentary, and potentially distorted understandings of the (sub)types in question. The main task of CroViMo will be to develop and test an innovative new classification of delinquent violence, the “genuine violence classification system” that will blend out the normative constraints of current mainstream classifications and focus strictly on the violence itself. Such a classification system might be a breakthrough in violence research. This ambitious work plan, if implemented successfully, should in the long run facilitate CroViMo’s development into a recognisable national, regional, and European “Violence Research Lab”, attracting further national and international scientific cooperation and successful joint funding applications, with a huge potential for dissemination of findings into practice.]]></summary_en></project><project>
<id>6824</id><title_hr><![CDATA[Derivati harmina kao potencijalni antimalarici]]></title_hr><title_en><![CDATA[Harmine derivatives as potential antimalarial agents]]></title_en><user_id>6183</user_id><user_firstLast_name>Zrinka Rajić Džolić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2017-05</proposal_call><code>UIP-2017-05-5160</code><acronim><![CDATA[CLICKforMALARIA]]></acronim><duration>01.04.2018 - 30.06.2023</duration><status>Završio</status><financ_value>233.193,97 eur</financ_value><scie_area_hr>Prirodne znanosti, Biomedicina i zdravstvo, </scie_area_hr><scie_area_en>Natural sciences, Biomedicine and health sciences, </scie_area_en><scie_field_hr>Farmacija, Kemija, </scie_field_hr><scie_field_en>Pharmaceutical sciences, Chemistry, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Farmaceutsko-biokemijski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Pharmacy and Biochemistry]]></institution_en><team_members_id>6174, 6538, 22512, 4758, 22514, 25221, 25308, 21322, 865248, 866031, </team_members_id><team_members_names><![CDATA[Ivana Perković, Kristina Pavić, Tamirat Gebru Woldearegai, Hrvoje Rimac, Diana Fontinha, Marina Marinović, Goran Poje, Maja Beus, Ana Penava, Lucija Bilandžija, ]]></team_members_names><keywords_hr><![CDATA[malarija, harmin, sinteza, antimalarijsko djelovanje, citotoksičnost, studije metabolizma]]></keywords_hr><keywords_en><![CDATA[malaria, harmine, synthesis, antimalarial activity, citotoxicity, metabolic studies]]></keywords_en><summary_hr><![CDATA[Malarija je smrtonosna bolest tropskih i subtropskih krajeva koja se prenosi ubodom komarca, a uzrokovana je parazitima roda Plasmodium. Cjepivo protiv malarije ne postoji, kao ni učinkovito uništavanje prijenosnika malarije. Osim toga, pojava otpornosti vrsta Plasmodium na postojeće lijekove dovodi do neučinkovitosti sadašnje terapije i zahtijeva otkriće lijekova s novim mehanizmima djelovanja. Alkaloidi b-karbolinskog tipa prisutni su u biljkama Peganum harmala i Eurycoma longifolia, koje se više od 2 tisućljeća koriste u tradicionalnoj kineskoj medicini za liječenje malarije i karcinoma. Djelatne supstancije ekstrakta biljke su alkaloidi harmin, harmalin, harmalol i harman. In vitro i in vivo studije pokazale su da harmin posjeduje snažno antimalarijsko djelovanje. Njegov mogući mehanizam djelovanja je inhibicija proteina toplinskog šoka 90 iz P. falciparum, koji je nužan za normalni razvoj parazita i ima važnu ulogu u razvoju rezistencije na postojeće antimalarike. U ovom projektu predviđeno je dizajniranje i sinteza knjižnice spojeva, koji se sastoje od harmina i 1) derivata cimetne kiseline (harmicini), 2) poznatih antimalarika: klorokina i meflokina (harmikini) i 3) ferocena (harmoceni). U sva tri tipa predviđenih spojeva poveznica će biti 1H-1,2,3-triazol, koji se pokazao korisnim u pripravi različitih biološki aktivnih spojeva. Predviđeni spojevi pripravit će se uobičajenim metodama sintetske organske kemije, te korištenjem modernih pristupa, &#39;&#39;click&#39;&#39; kemije i sinteze uz pomoć mikrovalova.Sintetiziranim spojevima ispitat će se antimalarijsko djelovanje in vitro, na eritrocitnu i hepatocitnu fazu plazmodija, te citoksično djelovanje na humane stanične linije. Uz to, provest će se studije metabolizma biološki aktivnih spojeva.Konačni rezultat projekta biti će novi spojevi učinkoviti protiv rezistentnih sojeva roda Plasmodium. Najaktivniji spojevi biti će polazišna točka za budući razvoj inovativnih lijekova.]]></summary_hr><summary_en><![CDATA[Malaria is a deadly mosquito-borne tropical and subtropical disease, caused the parazite of the genus Plasmodium. There is neither available vaccine, nor reliable vector control. In addition, Plasmodium is developing resistance to the existing therapy, which urges the discovery of novel drugs with new mechanisms of action.Alkaloids of b-carboline type are present in the medicinal plants Peganum harmala and Eurycoma longifolia, which have been used in the traditional Oriental medicine for the treatment of cancer and malaria. The active ingredients were identified as harmine, harmaline, harmalol and harman. In vitro and in vivo studies have proven harmine&#39;s antimalarial activity. Its possible mechanism of action is selective inhibition of P. falciparum heat shock protein 90, which is crucial for the parazite development and may play a major role in drug resistance. In the proposed project we decided to focus on the design and synthesis of a compound library, comprising harmine and 1) cinnamic acid moiety (harmicines), 2) known antimalarial drugs: chloroquine or mefloquine (harmiquines) and 3) ferrocene scaffold (harmocenes). The final compounds will incorporate 1H-1,2,3-triazole scaffolds, which proved to be useful in the synthesis of various biologically active compounds. Standard methods of synthetic organic chemistry, as well as modern approaches, such as click chemistry and microwave assisted synthesis will be employed. Antimalarial activity of the prepared compounds will be evaluated in vitro on both erythrocytic and hepatic stage of the Plasmodium, as well as cytotoxycity against human cell lines. In addition, metabolism studies for the biologically active compounds will be performed. As a final result, we will provide new candidate therapeutics against drug-resistant malaria parasite. The most active compounds will offer a valuable starting point for future development of innovative medicines.]]></summary_en></project><project>
<id>6829</id><title_hr><![CDATA[Istraživanje procesa koji se odvijaju u vodoopskrbnim sustavima]]></title_hr><title_en><![CDATA[Examination of the processes occurring in the drinking water distribution systems ]]></title_en><user_id>4429</user_id><user_firstLast_name>Magdalena Ujević Bošnjak</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2017-05</proposal_call><code>UIP-2017-05-3088</code><acronim><![CDATA[ProVoda]]></acronim><duration>01.04.2018 - 31.03.2023</duration><status>Završio</status><financ_value>341.138,31 eur</financ_value><scie_area_hr>Prirodne znanosti, Biomedicina i zdravstvo, </scie_area_hr><scie_area_en>Natural sciences, Biomedicine and health sciences, </scie_area_en><scie_field_hr>Kemija, Biologija, Javno zdravstvo i zdravstvena zaštita, </scie_field_hr><scie_field_en>Chemistry, Biology, Public health and health services, </scie_field_en><institution_hr><![CDATA[Hrvatski zavod za javno zdravstvo, Zagreb]]></institution_hr><institution_en><![CDATA[Croatian National Institute of Public Health, Zagreb]]></institution_en><team_members_id>19803, 22532, 4674, 25227, </team_members_id><team_members_names><![CDATA[Krunoslav Capak, Jurica  Štiglić, Mirjana Novak, Livia Kurajica, ]]></team_members_names><keywords_hr><![CDATA[voda za piće, vodoopskrbni sustav, nusprodukti dezinfekcije, arsen, olovo, nikal, naslage u cijevima, otpuštanje, biofilm, voda i zdravlje]]></keywords_hr><keywords_en><![CDATA[drinking water, distribution systems, disinfection by-products, arsenic, lead, nickel, pipe scales, release, biofilms, water and health]]></keywords_en><summary_hr><![CDATA[Fizički, kemijski i biološki procesi koji se odvijaju u vodoopskrbnim sustavima znatno utječu na kvalitetu vode koja se isporučuje potrošačima. Gotovo svi vodoopskrbni sustavi sadrže naslage krutih tvari. Prethodna istraživanja pokazala su da naslage bogate željezom u distribucijskim sustavima mogu akumulirati elemente u tragovima, čak i kada su oni prisutni u vodi za piće u koncentracijama nižim od maksimalno dopuštenih koncentracija, s mogućnošću naknadnog otpuštanja i transporta prema potrošačima u razdobljima velikog protoka. Procesi koji se odvijaju u vodoopskrbnim sustavima vrlo su složeni, a na njih utječu biotički i abiotički čimbenici. Promjene u sustavu, na primjer početak korištenja dezinfekcijskog sredstva ili prelazak na drugu vrstu dezinfekcijskog sredstva, utječu na kemizam vode i mogu uzrokovati lošiju kvalitetu vode kod potrošača nego li je bila na izlazu iz postrojenja za obradu vode.  Osim toga, pokazalo se da nusprodukti dezinfekcije, kao što su halooctene kiseline (HAA), koji nisu regulirani u Europskoj uniji, ako su prisutni s trihalometanima (THM), potiču otpuštanje kontaminanata iz naslaga u vodenu fazu. Glavni je cilj ovog projekta istražiti fizikalno-kemijske i mikrobiološke procese koji se odvijaju u vodoopskrbnim sustavima u različitim uvjetima i utječu na otpuštanje kontaminanata iz materijala nakupljenog u vodoopskrbnoj mreži. Istraživanje će biti provedeno u tri vodoopskrbna sustava u Hrvatskoj s različitim sastavom voda. Uzorkovat će se te  kemijski i mikrobiološki analizirati uzorci vode i naslaga. Također će se provesti laboratorijski eksperimenti kako bi se dalje proučavali uočeni procesi. Rezultati će biti statistički obrađeni, a procesi koji se odvijaju u vodoopskrbnim sustavima bit će modelirani. Kako je opskrba zdravstveno ispravnom vodom za piće temelj javno-zdravstvene zaštite stanovništva, izvršit će se procjena rizika za ljudsko zdravlje vezana uz prisutnost nusprodukata dezinfekcije (THM i HAA) u vodi za piće.]]></summary_hr><summary_en><![CDATA[Physical, chemical, and biological processes that take place in the distribution system largely influence water quality reaching consumer’s tap. Almost all drinking water distribution systems (DWDS) contain solids. Previous research showed that iron-rich deposits in the distribution systems can accumulate trace elements, even present in the drinking water below maximum allowable limit, with potential for subsequent removal and transport to consumers at periods of high flow. The processes occurring in the drinking water distribution systems are very complex and influenced by biotic and abiotic factors. Switching from nondisinfection to disinfection, or changing the type of disinfectant used will influence water chemistry and can cause water quality deterioration at the consumer tap when compared to the original water produced at the treatment plant. Furthermore, it is shown that in the EU, nonregulated disinfection by-products such as haloacetic acids (HAA) if present with trihalomethane (THM) promote release of contaminants from scales  in finished water. The main goal of this project is to understand the physicochemical and microbiological processes that occur in the DWDS under various conditions and influence release of contaminants from the material retained in the network. Research will be conducted in the three DWDS in Croatia exhibiting different water compositions, from which water and solid samples will be taken and chemically and microbiologically analyzed. Laboratory experiments will be conducted to study observed processes in further depth. The results will be statistically processed, whereas the processes taking place in DWDS will be modelled. Since the provision of safe drinking water is essential from the public health point, the assessment of public health risks related to presence of the disinfection by products (THMs and HAAs) in the drinking water will be done.]]></summary_en></project><project>
<id>6833</id><title_hr><![CDATA[Kulturni krajolik – model valorizacije, zaštite, upravljanja i korištenja kulturne baštine]]></title_hr><title_en><![CDATA[The Cultural Landscape - A Model for Valorisation, Protection, Management and Use of Cultural Heritage]]></title_en><user_id>22523</user_id><user_firstLast_name>Igor Kulenović</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2017-05</proposal_call><code>UIP-2017-05-2152</code><acronim><![CDATA[ProHeritage]]></acronim><duration>01.01.2018 - 31.12.2022</duration><status>Završio</status><financ_value>115.353,57 eur</financ_value><scie_area_hr>Humanističke znanosti, Društvene znanosti, </scie_area_hr><scie_area_en>Humanities, Social sciences, </scie_area_en><scie_field_hr>Arheologija, Sociologija, Povijest, </scie_field_hr><scie_field_en>Archeology, Sociology, History, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zadru]]></institution_hr><institution_en><![CDATA[University of Zadar]]></institution_en><team_members_id>22524, 22536, 19329, 17616, 19351, 22581, 17610, 18940, 25014, 5733, 861527, </team_members_id><team_members_names><![CDATA[Neda Kulenović Ocelić, Filomena Sirovica, Vedrana Glavaš, Gabrijela Vidić, Martina Dubolnić Glavan, Šime Vrkić, Vinko BAKIJA, Miro Stošić, Denis Radoš, Uroš Stepišnik, Sara Iglić, ]]></team_members_names><keywords_hr><![CDATA[kulturna baština, kulturni krajolik, karakterizacija povijesnog krajolika, GIS, valorizacija, zaštita, upravljanje]]></keywords_hr><keywords_en><![CDATA[cultural heritage, cultural landscape, HLC, valorisation, protection, management]]></keywords_en><summary_hr><![CDATA[Arheologija je u posljednjih 20-ak godina doživjela nekoliko transformacija. Osim epistemoloških i teorijskih zaokreta arheologiju su oblikovale nove tehnologije i novi mediji koji su stvorili nove perspektive i područja rada. Jedna od najvećih transformacija koja se je dogodila u arheologiji je razvoj arheologije krajolika. Ovaj zaokret su popratile i različite legislative od kojih je najznačajnija Europska konvencija o krajoliku (Firenca 2000.). Sukladno tome su razvijene metode i procedure valorizacije, zaštite i upravljanja baštinom na temelju krajolika. Cilj ovog projekta je razviti hrvatski model valorizacije, zaštite, upravljanja I korištenja kulturne baštine, a temeljen na krajoliku. Uzor za razvijanje modela je upravo Engleski model valorizacije baštine kroz platformu Povijesne Karakterizacije Krajolika (Historic Landscape Characterisation - HLC). Metodologija za provođenje projekta je metodologija arheologija krajolika. Studija slučaja koja je izabrana za izradu modela je područje današnje Općine Jasenice i Grada Obrovca. Područje studije slučaja predstavlja dovoljno velik prostorni uzorak za primjenu temeljnih principa Povijesne Karakterizacije Krajolika. Ova platforma, jednako kao i procedure će biti dodatno razrađene uzevši u obzir specifičnosti baštine u kršu. Modeli koji će nastati kroz ovaj projekt će biti primjenjivi za ostale krške dijelove Hrvatske, a na metodološkoj razini i na cijelu zemlju. Osim valorizacije i zaštite baštine projekt za cilj ima i razvijanje primijenjene arheologije kao svojevrsne ekstenzije primarne struke, a kroz sinergiju sa društvenim znanostima. Interdisciplinarnost je sadržana u radu na području razvoja kulturnog i baštinskog turizma. Koraci u tom smjeru su izrada zajedničkog kategorijskog aparata, jedinstvene terminologije, akcijskih planova i strategija s ciljem uspostave procedura za upravljanje i korištenje baštine po principu održivosti, a ujedno usmjerene na očuvanje prostora, krajolika i baštine.]]></summary_hr><summary_en><![CDATA[Archaeology has experienced several transformations in the last 20 years. Apart from epistemological and theoretical turns, archaeology was shaped by new technologies and new media enabling new perspectives and areas of practice. One of the greatest transformations which happened in archaeology was the development of landscape archaeology. This turn was followed by various legislation, the most significant being European Landscape Convention (Florence 2000). Accordingly, new methods and procedures were developed including valorisation, protection and heritage management based on landscape.The aim of this project is to developed Croatian model of valorisation, protection, management and use of cultural heritage, based on the landscape. The role model is precisely the English model of heritage valorisation through Historic Landscape Characterisation (HLC) platform. Project methodology is in fact a methodology developed within landscape archaeology. The case study selected to develop the model is an area of Jasenice Municipality and Town of Obrovac. It presents a large enough spatial sample to apply basic HLC principles. This platform as well as the procedures will be additionally developed considering specificities of heritage in karst. Models that will be created through this project will be applicable on other karst areas in Croatia and at the methodological level on the whole country. Apart from valorisation and protection of heritage, the aim of the project is to develop applied archaeology as an extension of the primary discipline, through synergy with social sciences. Interdisciplinarity of the project is reflected in areas such as the development of cultural and heritage tourism. Steps in that direction include conceptualisation of joint categorical apparatus and terminology, action plans and strategies in order to establish procedures for management and use of heritage based on sustainability principles and preservation of space, landscape and heritage.]]></summary_en></project><project>
<id>6836</id><title_hr><![CDATA[Šteta, namjere i odgovornost]]></title_hr><title_en><![CDATA[Harm, Intentions and Responsibility]]></title_en><user_id>22529</user_id><user_firstLast_name>Matej Sušnik</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2017-05</proposal_call><code>UIP-2017-05-4308</code><acronim><![CDATA[HIRe]]></acronim><duration>01.01.2018 - 31.12.2022</duration><status>Završio</status><financ_value>92.945,78 eur</financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Filozofija, </scie_field_hr><scie_field_en>Philosophy, </scie_field_en><institution_hr><![CDATA[Institut za filozofiju]]></institution_hr><institution_en><![CDATA[Institute for Philosophy in Zagreb]]></institution_en><team_members_id>2690, 4172, 22551, 25046, 861686, 858392, </team_members_id><team_members_names><![CDATA[Tvrtko Jolić, Marko Jurjako, Marin Biondić, Karolina Kudlek, Viktor Ivankovic, Ana Grgić, ]]></team_members_names><keywords_hr><![CDATA[Šteta, namjere, odgovornost, smrt, psihopatija, dopustivost, rat]]></keywords_hr><keywords_en><![CDATA[Harm, intentions, responsibility, death, psychopathy, permissibility, war]]></keywords_en><summary_hr><![CDATA[Šteta, namjera i odgovornost središnji su pojmovi oko kojih se odvijaju suvremene rasprave na području etike, političke filozofije i filozofije djelovanja. Naše istraživanje uklapa se u recentne filozofske rasprave koje tematiziraju značenje tih pojmova kao i njihove normativne implikacije u raznim domenama našega svakodnevnoga života. Istraživanje ćemo podijeliti u tri dijela: (1) Priroda štete; (2) Šteta i moralni značaj namjera; te (3) Individualna i kolektivna odgovornost. U posljednjoj fazi istraživanja objedinit ćemo prethodno ostvarene rezultate s namjerom zadobivanja jedinstvene i koherentne slike o tome na koji su način navedeni pojmovi međusobno povezani.]]></summary_hr><summary_en><![CDATA[Harm, intention, and responsibility are the central concepts around which contemporary discussions on ethics, political philosophy and philosophy of action take place. Our research fits into recent philosophical discussions that discuss the meaning of these concepts as well as their normative implications in the various domains of our everyday life. The research will be divided into three parts: (1) The nature of harm; (2) Harm and the moral significance of intentions; and (3) Individual and collective responsibility. In the last phase of the research, we will combine previously achieved results with the aim of obtaining a unique and coherent image of how these notions are related to each other.]]></summary_en></project><project>
<id>6843</id><title_hr><![CDATA[MOLEKULARNI MEHANIZMI TOKSIČNOSTI PROTUOTROVA I POTENCIJALNIH LIJEKOVA]]></title_hr><title_en><![CDATA[MOLECULAR MECHANISMS UNDERLYING THE TOXICITY OF ANTIDOTES AND POTENTIAL DRUGS]]></title_en><user_id>982</user_id><user_firstLast_name>Maja Katalinić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2017-05</proposal_call><code>UIP-2017-05-7260</code><acronim><![CDATA[CellToxTargets]]></acronim><duration>01.03.2018 - 28.02.2023</duration><status>Završio</status><financ_value>224.739,53 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Biologija, Kemija, </scie_field_hr><scie_field_en>Biology, Chemistry, </scie_field_en><institution_hr><![CDATA[Institut za medicinska istraživanja i medicinu rada]]></institution_hr><institution_en><![CDATA[Institute for Medical Research and Occupational Health]]></institution_en><team_members_id>22563, 226, 22504, 657, 19605, 858373, </team_members_id><team_members_names><![CDATA[Sergej Pirkmajer, Ivana Vrhovac Madunić, Antonio Zandona, Nikola Maraković, Josip  Madunić, Ana-Marija Lulić, ]]></team_members_names><keywords_hr><![CDATA[antidoti, organofosforni spojevi, stanice, enzimi, nuspojave]]></keywords_hr><keywords_en><![CDATA[antidotes, organophosphorus compounds, cells, enzymes, side-effects]]></keywords_en><summary_hr><![CDATA[Predloženi projekt predstavlja nov i inovativan pristup u istraživanju protuotrova organofosfornim spojevima (OP), s potencijalom opće primjene u području dizajna novih lijekova. Glavni cilj predloženog projekta je odgovoriti na pitanje kako protuotrovi i potencijalni lijekovi djeluju na staničnoj razini te otkriti mehanizme okidače za neželjene učinke ili nuspojave in vivo. Kako bi se utvrdio mehanizam koji stoji iza takve toksičnosti spojeva i kako bi se potpomognula učinkovitija selekcija kandidata za razvoj lijeka, primijenit će se specifični pretklinički probir temeljen na staničnim testovima. Unutar predloženog projekta ispitat ćemo nekoliko strukturno povezanih setova spojeva. Po dobivanju rezultata istraživanja, moći ćemo primijeniti pristup analize strukture i aktivnosti kako bismo odredili moguće strukturne značajke ispitanih spojeva odgovorne za određene učinke. Tako se značajke poput tih mogu modificirati u ranoj fazi poboljšanja strukture vodećeg spoja bez provođenja ikakvih studija in vivo. To će omogućiti i učinkovitije povratne informacije istraživačima koji rade na oblikovanju npr. protuotrova i doprinijeti razvoju djelotvornije terapije za trovanje OP spojevima. Očekujemo i identifikaciju novih farmakoloških meta na staničnoj razini, kao i mogućnost istraživanja njihovog terapijskog potencijala. Jedna takva meta kod tretmana trovanja OP-ovima, koja je identificirana u našem istraživanju, je novi enzim NRE. Stoga ćemo ispitati ulogu i funkciju ovog enzima i odgovoriti bi li se isti mogao razmatrati kao ciljna molekula u liječenju otrovanja OP-ima ili bi mogao imati indikaciju u liječenju drugih stanja i bolesti. Ovi bi rezultati otvorili i novu perspektivu s utjecajem koji nadilazi prvotno polje primjene. Uz ovaj znanstveni dio, iskusni i kvalificirani istraživački tim nastavit će poticati prijenos tehnologije putem raznih suradnji, kontinuirane nadogradnje i unaprjeđenja metoda te osposobljavanjem u području specifičnih vještina.]]></summary_hr><summary_en><![CDATA[The project presents the new innovative approach in the field of antidote research for poisoning with organophosphates (OP), having the applications in overall drug discovery. The main goal of the project is to answer how the antidotes and drugs act on cell level and uncover the trigger mechanism leading to the side-effects or even severe effects that could occur in vivo. The specific cell-based screening will be applied to define the mechanism behind such unwanted toxicity of compounds and to aid a more efficient selection of a lead candidate for drug development. Within the proposed project, we will test several defined sets of structurally related antidotes/drugs. This will allow us to use, after obtaining sufficient cell-based data, a structure-activity approach to define the possible structural features of tested compounds triggering certain effects. Thus, features like these could be modified in the early lead compound structure refinement process without performing any in vivo studies. More efficient feedback will be given to studies designing drugs and aid the challenging development of an effective treatment primarily for OP poisoning. We also expect to identify new possible targets on the cell level and explore their therapeutic potential. One such target in treating exposure to OPs, NRE, was identified in our earlier research. Therefore, we will study the role and function of this unexplored enzyme and answer whether it could be considered as a potential target in OP treatment or even has an indication for being a target molecule in treatment of other diseases. Our findings should open up a new perspective with potential impact beyond the original scope. Beside the scientific part, the newly established experienced and skilled research team will stimulate a technology transfer through collaborations, continuous upgrading and improvement of methods and training in specific skills.]]></summary_en></project><project>
<id>6846</id><title_hr><![CDATA[Opasnosti i prednosti društvenih mreža: e-profesionalizam zdravstvenih djelatnika]]></title_hr><title_en><![CDATA[Dangers and benefits of social networks: e-professionalism of healthcare professionals ]]></title_en><user_id>22544</user_id><user_firstLast_name>Tea Vukušić Rukavina</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2017-05</proposal_call><code>UIP-2017-05-2140</code><acronim><![CDATA[SMePROF]]></acronim><duration>09.05.2018 - 01.11.2023</duration><status>Završio</status><financ_value>127.364,13 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Javno zdravstvo i zdravstvena zaštita, Dentalna medicina, </scie_field_hr><scie_field_en>Public health and health services, Dental medicine, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb School of Medicine]]></institution_en><team_members_id>22559, 22557, 22739, 25312, 861501, </team_members_id><team_members_names><![CDATA[Joško Viskić, Danko Relic Relic, Kristijan Sedak, Marko Marelić, Lovela Machala Poplašen, ]]></team_members_names><keywords_hr><![CDATA[e-profesionalizam, zdravstveni djelatnici, društvene mreže, zdravstvena edukacija, studenti, smjernice]]></keywords_hr><keywords_en><![CDATA[e-professionalism, health care professionals, social media, health education, students, guidelines]]></keywords_en><summary_hr><![CDATA[Predloženi projekt ima za cilj istraživanje utjecaja društvenih mreža na e-profesionalizam zdravstvenih djelatnika u Republici Hrvatskoj gdje je e-profesionalizam definiran kao predanost izvršavanju profesionalne zadaća, pridržavanju etičkih principa i osjetljivosti za pacijentovu dobrobit tijekom on-line aktivnosti na društvenim mrežama te na osnovu rezultata razviti i testirati smjernice za poticanje razvoja e-profesionalizma zdravstvenih djelatnika. Rezultati ovog projektnog prijedloga pridonijet će boljem razumijevanju kako se e-profesionalizam razvija tijekom obrazovanja i prakse u zdravstvenoj skrbi. Rezultati istraživanja omogućit će detaljan uvid o korištenju društvenih mreža među zdravstvenim djelatnicima u Republici Hrvatskoj (studentima i nastavnicima medicine i dentalne medicine te doktorima medicine i dentalne medicine) te će se utvrditi razlike ovisno o podgrupi ispitanika čime će se omogućiti usporedba s rezultatima prethodno provedenih međunarodnih istraživanja. Identificiranjem kriterija kojima korisnici društvenih mreža procjenjuju profesionalizam zdravstvenih djelatnika na društvenim mrežama te vjerodostojnost i kvalitetu pruženih informacija omogućit će se razvijanje teorijske postavke modela za kreiranje preporuka o profesionalno adekvatnom ponašanju na društvenim mrežama u skladu su potrebnim vještinama koje omogućuju odgovorno ponašanje i očuvanje kredibiliteta profesije. Rezultati istraživanja će se primijeniti kao temelj za razvoj novih znanstveno utemeljenih edukativnih sadržaja o e-profesionalizmu u kurikulumima MEF-a i SFZG-a te će pridonijeti unaprjeđenju cijelo-životnog učenja zdravstvenih djelatnika. Ovim istraživanjem će se utvrditi determinante koje u pozitivnom i negativnom aspektu utječu na e-profesionalizam zdravstvenih djelatnika, obuhvaćajući sve generacije zdravstvenih djelatnika, te na taj način pridonijeti boljem razumijevanju dinamike kompleksnog odnosa u dinamičnom okruženju društvenih mreža koje se neprestano razvija.]]></summary_hr><summary_en><![CDATA[Aim of the proposed project is to explore the impact of social networks on e-professionalism of healthcare professionals in the Republic of Croatia where e-professionalism is defined as a commitment to carry out a professional task, adhering to ethical principles and sensitivity to patient&#39;s well-being during on-line activities on social networks, and based on these results develop and test guidelines to encourage the development of e-professionalism of the professional staff. The result of the project proposal will contribute to a better understanding of how e-professionalism develops during education and practice in health care. The results of the research will provide a detailed insight into the use of social networks among healthcare professionals in the Republic of Croatia and will determine the differences in attitudes and behaviors depending on the subgroup of respondents, which will enable comparison with the results of previously conducted international research. By identifying the criteria based on which social network users evaluate the professionalism of health professionals on social networks and the credibility and quality of information provided, it will enable the development of the theoretical set of models for the development of recommendations on professionally adequate behavior on social networks in accordance with the necessary skills that enable responsible behavior and the preservation of the credibility of the profession. This research will identify all determinants that affect the e-professionalism of health professionals in a positive and negative aspect, including all generations of healthcare professionals, and thus contribute to a better understanding of the dynamics of this evolving interaction. Results will be used as a basis for the development of new, evidence-based educational content on e-professionalism in School of Medicine and School of Dental Medicine University of Zagreb curricula.]]></summary_en></project><project>
<id>6851</id><title_hr><![CDATA[Utjecaj polimera na radiolitičku sintezu magnetskih nanočestica]]></title_hr><title_en><![CDATA[The impact of polymers on the radiolytic synthesis of magnetic nanoparticles]]></title_en><user_id>350</user_id><user_firstLast_name>Tanja Jurkin</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2017-05</proposal_call><code>UIP-2017-05-7337</code><acronim><![CDATA[POLRADNANOP]]></acronim><duration>01.03.2018 - 31.08.2023</duration><status>Završio</status><financ_value>214.962,03 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, </scie_field_hr><scie_field_en>Chemistry, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>616, 25099, </team_members_id><team_members_names><![CDATA[Anđela Pustak, Ivan Marić, ]]></team_members_names><keywords_hr><![CDATA[polimeri, gama-zračenje, magnetske nanočestice,  Au, prevlaka, SERS]]></keywords_hr><keywords_en><![CDATA[polymers, gamma-irradiation, magnetic nanoparticles, gold layer, SERS]]></keywords_en><summary_hr><![CDATA[U ovom uspostavnom istraživačkom projektu istraživat će se utjecaj raznih polimera na gama-radiolitičku sintezu superparamagnetskih nanočestica željezovog oksida (SPION). SPION-i su odabrani kao modelni sustav radiolitički sintetiziranih nanočestica. SPION-i se mogu koristiti u raznim primjenama poput nosača za isporuku lijeka, kontrastnih sredstava, liječenja hipertermijom, razlaganja vode i kod magnetskog razdvajanja proteina. Radiolitička sinteza nanočestica (NČ) je novo područje istraživanja u Hrvatskoj koje do sada nikada nije bilo financirano. Treba istaknuti da predlagateljica projekta ima znanstvenu i eksperimentalnu podlogu u tom području. U ovom projektu sustavno će se istraživati utjecaj gama-zračenja kao i utjecaj odabranih polimera (poput PVP-a, dekstrana i PEO-a) na koloidnu stabilnost radiolitički sintetiziranih SPION-a, njihovu veličinu, oblik i fazni sastav. Pored toga, redukcijska svojstva ispitivanih polimera mjerit će se kvantitativnim određivanjem koncentracije nastalih Fe2+ iona u ozračenim suspenzijama. Konkretno, koncentracija Fe2+ iona bit će određena spektrofotometrijskom tehnikom upotrebom 1,10-fenantrolina i/ili redoks titracijom pomoću otopine kalijevog permanganata. U ovom projektu naći će se optimalni eksperimentalni uvjeti (najpogodniji polimer, doza i brzina doze gama-zračenja) za radiolitičku sintezu stabilne suspenzije nanočestica magnetita, odnosno SPION-a. Da bi se dobio nanomaterijal aktivan za površinski pojačanu Ramanovu spektroskopiju (SERS), površina SPION-a obložit će se zlatom (SPION@Au). Kakvoća i homogenost zlatne prevlake bitno ovisi o postupku oblaganja. U ovom projektu zlato će se nanijeti na SPION-e radiolitičkom tehnikom. Kakvoća zlatnih prevlaka ispitat će se UV-Vis spektroskopijom i visoko rezolucijskom elektronskom mikroskopijom. Uporaba SPION@Au NČ za određivanje mikromolarnih koncentracija organskih boja prisutnih u vodenoj otopini istraživat će se površinski pojačanom Ramanovom spektroskopijom.]]></summary_hr><summary_en><![CDATA[In this installation research project the impact of various polymers on the gamma radiolytic synthesis of superparamagnetic iron oxide nanoparticles (SPIONs) will be studied. The SPIONs are selected as model radiolytically synthesized nanoparticles (NPs). SPIONs can be used in various applications such as drug delivery, contrast agents, hyperthermia treatments, water splitting, magnetic separation, etc. The radiolytic synthesis of nanoparticles is new area of investigation in Croatia that has never been financially supported by Croatian authorities. It should be pointed out that project applicant has scientific and experimental background in the field. In this project we will systematically study the influence of irradiation conditions and the impact of certain polymers, such as PVP, dextran, PEO, etc., on colloidal stability of radiolitically synthesized SPIONs, their size and shape and phase composition. In addition, the reducing ability of investigated polymers will be quantitatively determined by measuring ferrous (Fe2+) ions concentration formed in irradiated suspensions. The spectrophotometric technique using 1,10-Phenanthroline or redox titration using potassium permanganate solution will be used for Fe2+ determination. The optimal experimental conditions (the most suitable polymer, irradiation dose and dose rate) for radiolytically synthesized magnetite suspension, i.e. SPIONs will be found. In order to obtain Surface Enhanced Raman Spectroscopy (SERS) active material, the surface of SPIONs will be coated with gold (SPIONs@Au core-shell NPs). The quality and homogeneity of gold coating depends significantly on the coating procedure. In this project gold will be coated onto SPIONs using radiolytic technique. The gold coatings will be examined using UV-Vis spectroscopy and high resolution electron microscopy. The capacity of SPIONs@Au NPs for determination of micromolar concentrations of organic dye dissolved in aqueous solution will be tested using SERS.]]></summary_en></project><project>
<id>6858</id><title_hr><![CDATA[Učinkovita stvarnovremenska obrada brzih geoprostornih podataka]]></title_hr><title_en><![CDATA[Efficient Real-Time Processing of Fast Geospatial Data]]></title_en><user_id>2706</user_id><user_firstLast_name>Krešimir Pripužić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2017-05</proposal_call><code>UIP-2017-05-9066</code><acronim><![CDATA[RETROFIT ]]></acronim><duration>01.03.2018 - 28.02.2023</duration><status>Završio</status><financ_value>167.720,92 eur</financ_value><scie_area_hr>Tehničke znanosti, Prirodne znanosti, </scie_area_hr><scie_area_en>Technological sciences, Natural sciences, </scie_area_en><scie_field_hr>Računarstvo, Geografija, </scie_field_hr><scie_field_en>Computer sciences, Geography, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id>6720, 17866, 3137, 22607, 22730, 22460, 5345, 858427, </team_members_id><team_members_names><![CDATA[Aleksandar Antonić, Martina Marjanović, Mladen Maradin, Ivan Livaja, Mirjana Pripužić, Siniša Sovilj, Damjan Katušić, Josip Marić Marić, ]]></team_members_names><keywords_hr><![CDATA[raspodijeljena obrada podataka, obrada velikih podataka, internet stvari, stvarnovremenska obrada podataka, primijenjeno strojno učenje]]></keywords_hr><keywords_en><![CDATA[distributed data processing, big data processing, internet of things, real-time data processing, applied machine learning]]></keywords_en><summary_hr><![CDATA[Svjedoci smo dramatične tranzicije našeg suvremenog informacijski usmjerenog svijeta kojom iz razdoblja samo jednog uređaja povezanog na Internet po osobi prelazimo u razdoblje Interneta stvari u kojem po osobi postoji mnoštvo povezanih uređaja. Mnogi od ovih uređaja generiraju specifičnu vrstu strujećih podataka koji su najčešće velike frekvencije, ali uglavnom male veličine, te se nazivaju se Brzi podaci. Projekt RETROFIT (Učinkovita stvarnovremenska obrada brzih geoprostornih podataka) rješavat će otvorena pitanja vezana uz filtriranje i obradu brzih podataka u stvarnom vremenu. Pritom će se uglavnom usredotočiti na brze geoprostorne podatke, kao posebnu vrstu brzih podataka koji uključuju geoprostorne informacije (npr. geografsku širinu i dužinu). Kroz svoje ciljeve istraživanja, projekt RETROFIT će istražiti učinkovitu usporedbu pristiglih brzih geoprostornih podataka s unaprijed definiranim interesima za njima te primjenu tehnika strojnog učenja u stvarnom vremenu nad njima kako bi ponudio rješenje za stvarnovremensku obradu brzih geoprostornih podataka. Kako bi se učinkovito nosio s problemom velike frekvencije takvih podataka, projekt RETROFIT će se usredotočiti na raspodijeljenu obradu podataka u računalnom grozdu. Identificirat će se nekoliko studijskih slučajeva u kojima je nužna stvarnovremenska obrada brzih geoprostornih podataka, kao što je npr. sustav ranog upozoravanja na poplave koji obrađuje podatke o vodostajima, protjecajima i padalinama u stvarnom vremenu. Ciljevi projekta će se postići sustavnim pristupom istraživanju i ostvarivim planom rada. Osim toga, uspostavit će se multidisciplinarna istraživačka skupina i postavit će se eksperimentalni računalni grozd u laboratoriju. Razvijeno rješenje, kao i stečeno znanje, poslužit će kao osnova za prijavu na druge izvore financiranja u završne dvije godine projekta, što će omogućiti održivost projekta RETROFIT.]]></summary_hr><summary_en><![CDATA[We are witnessing a dramatic transition in our modern information-oriented world from the age of a single Internet-connected device per person into the age of the Internet of Things (IoT) where there is a multitude of connected devices per person. Many of these devices generate a specific type of streaming data which is usually highly frequent, but mostly small in size, and is called the Fast data. The project RETROFIT (Efficient Real-Time Processing of Fast Geospatial Data) will address open questions regarding the real-time filtering and processing of the Fast data. In doing so, it will mostly focus on the fast geospatial data, as a special type of Fast data which includes geospatial information (e.g. latitude, longitude). Through its research objectives, the RETROFIT project will investigate efficient matching of generated fast geospatial data with predefined interests in such data and usage of machine learning techniques in real-time on such data to provide a solution for real-time processing of the fast geospatial data. To efficiently deal with the problem of a high frequency of such data, the RETROFIT project will focus on distributed data processing in the computer cluster. A several case studies, in which real-time processing of fast geospatial data is required, will be identified, such as an early warning system for floods which processes water level, discharge and precipitation data in real-time. The RETROFIT project objectives will be reached through the systematic approach to research and a realistic work plan. Additionally, a multidisciplinary research group will be established and an experimental computer cluster will be set up in the laboratory. The developed solution, as well as gained knowledge, will be used as the basis for applying to other funding sources in the last two project years, which will enable viability of the RETROFIT project.]]></summary_en></project><project>
<id>6859</id><title_hr><![CDATA[Diamantoidni sustavi s heteroatomima – priprava i primjena u razvoju naprednih materijala]]></title_hr><title_en><![CDATA[Diamondoid scaffolds containing heteroatoms – preparation and application in development of advanced materials]]></title_en><user_id>2988</user_id><user_firstLast_name>Marina Šekutor</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2017-05</proposal_call><code>UIP-2017-05-9653</code><acronim><![CDATA[DiamMat]]></acronim><duration>01.09.2018 - 31.08.2023</duration><status>Završio</status><financ_value>162.585,44 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, </scie_field_hr><scie_field_en>Chemistry, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>3215, 3336, 28147, </team_members_id><team_members_names><![CDATA[Marija Alešković, Margareta  Sohora, Nataša  Burić, ]]></team_members_names><keywords_hr><![CDATA[diamantoidi, napredni materijali, organska sinteza, kavezasti spojevi, policiklički ugljikovodici, polifunkcionalizacija, alkilni derivati]]></keywords_hr><keywords_en><![CDATA[diamondoids, advanced materials, organic synthesis, cage compounds, polycyclic hydrocarbons, polyfunctionalization, alkyl derivatives]]></keywords_en><summary_hr><![CDATA[Razvoj novih materijala je tema od iznimne važnosti u kemiji te su najnovija istraživanja posvećena otkriću, poboljšanju i primjeni materijala u tehnologijama budućnosti. Naročito su intenzivne studije materijala baziranih na ugljiku, pri čemu je dijamant jedan od primjera. Međutim primjena dijamanta, unatoč njegovim mnogobrojnim izvrsnim svojstvima, ostaje ograničena zbog problema u kontroli selektivnosti njegove funkcionalizacije te nedovoljne uniformnosti strukture. Pogodna alternativa dijamantu su diamantoidi, organski kavezasti spojevi koji posjeduju sličnu strukturu, no koji se mogu selektivno supstituirati. Diamantoidi su stoga na granici između fleksibilnih organskih molekula i anorganskog dijamanta.Kemija diamantoida se značajno razvila u protekla dva desetljeća, no još uvijek ima prilika za daljnji napredak. Naš cilj je pripraviti i okarakterizirati dosad neistražene diamantoidne derivate te ih primijeniti u dizajnu materijala. Ciljne molekule bit će diamantoidni sustavi s heteroatomima uvedenim izravno na kavezastu podjedinicu, a pripravit će se i derivati s poveznicama („spacer“). Planirani spojevi uključuju diamantoidne etere, tioetere, amine (sekundarni i viši), estere, itd. Kako bi se postigli zadani ciljevi, bit će razvijene nove strategije za selektivnu funkcionalizaciju i polifunkcionalizaciju ovakvih spojeva jer precizna supstitucija diamantoida omogućava kontrolu njihovih svojstava. Daljnji korak bit će dizajn svojstava uvođenjem sekundarnih funkcionalnih skupina, a sa ciljem buduće primjene ovakvih spojeva u premazima te kao površinski slojevi na metalima ili poluvodičima. Eksperimentalna istraživanja bit će nadopunjena računalnim metodama kako bi se dobio uvid u fizikalno-kemijska svojstva pojedinih molekula, ali i novonastalih materijala. Predložena temeljna istraživanja će stoga produbiti spoznaje o utjecaju strukture na svojstva naprednih materijala te omogućiti dizajn novih „lead“ spojeva temeljenih na ugljikovim organskim sustavima.]]></summary_hr><summary_en><![CDATA[Development of new materials is an important key topic in chemistry and cutting edge research is devoted to discover, improve and apply them in future technologies. Currently special focus is placed on carbon-based materials, with diamond being a highly attractive scaffold. Despite its numerous excellent properties, diamond is still difficult to control in terms of selective functionalization and material uniformity. An alternative to bulk diamond are diamondoids, organic cage compounds that have a diamond-like structure but can be selectively substituted, thereby bridging the gap between flexible organic molecules and bulk diamond.Chemistry of diamondoids saw a breakthrough in the last two decades but there are still opportunities for further development. Our goal is to prepare and characterize unexplored diamondoid derivatives and apply them in materials design. Target compounds will be diamondoid scaffolds selectively functionalized with heteroatoms bound on the cage itself as well as derivatives with spacers, including ethers, thioethers, amines (secondary and higher), esters, etc. To achieve this, we will go beyond the state-of-the-art and develop new strategies for their selective functionalization and polyfunctionalization, since precise diamondoid substitution enables properties control. The next step will be tailoring of properties by introduction of secondary motifs/functionalities on the prepared diamondoid scaffolds, with a goal to pave the way for future application in coatings and advanced surfaces. Experimental studies will be complemented by computational methods to gain more insight into the physico-chemical nature of both the molecules and the materials they will form. The proposed research will therefore deepen the fundamental knowledge of structure-properties relationship in the design of new candidates for advanced materials, with a focus on highly promising carbon-based organic scaffolds.]]></summary_en></project><project>
<id>6861</id><title_hr><![CDATA[Razvoj postupaka kosimulacija programskih alata za primjenu mekog računarstva u elektroenergetici]]></title_hr><title_en><![CDATA[Co-simulation procedures development for soft computing application in power engineering]]></title_en><user_id>2962</user_id><user_firstLast_name>Marinko Barukčić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2017-05</proposal_call><code>UIP-2017-05-8572</code><acronim><![CDATA[COPESOC]]></acronim><duration>25.05.2018 - 24.11.2023</duration><status>Završio</status><financ_value>211.913,29 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Elektrotehnika, </scie_field_hr><scie_field_en>Electrical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište Josipa Jurja Strossmayera Osijek, Fakultet elektrotehnike, računarstva i informacijskih tehnologija Osijek]]></institution_hr><institution_en><![CDATA[Josip Juraj Strossmayer University of Osijek, Faculty of Electrical Engineering, Computer Science and Information Technology Osijek]]></institution_en><team_members_id>22642, 3110, 25170, </team_members_id><team_members_names><![CDATA[Tin Benšić, Vedrana Jerković Štil, Toni Varga, ]]></team_members_names><keywords_hr><![CDATA[elektroenergetika, distributivne mreže, industrijske mreže, kosimulacija, metode mekog računarstva]]></keywords_hr><keywords_en><![CDATA[electrical power, distribution network, industrial network, co-simulation, soft computing methods]]></keywords_en><summary_hr><![CDATA[U novije vrijeme u području električnih mreža i elektromotornih pogona aktualna je problematika vezana uz obnovljive izvore, energetski samoodržive mreže (mikro mreže), napredne (pametne, inteligentne sustave) i poboljšanje energetske učinkovitosti. Pri rješavanju ovih problema potrebno je provesti brojne simulacije za planiranje i upravljanje sustava. Prilikom toga nužno je što realističnije modelirati fizikalne pojave i razviti procedure koje će u kraćem vremenu dati preciznije rezultate. Realistično modeliranje uzrokuje visoku složenosti matematičkih modela što ograničava primjenu klasičnih metoda. Prilagodba metoda mekog računarstva rješavanju problema u elektroenergetici otvara mogućnost povećavanja kvalitete simulacija uz smanjenje vremena proračuna. Primjena ovih metoda se brzo razvija usljed brzog razvoja računalnih znanosti (računalnih sklopova i programa). Recentna literatura ukazuje na robusnost u primjenjivosti navedenih metoda. Svrha projektnog prijedloga je razvojem procedura za sinergiju tj. kosimulaciju algoritama mekog računarstva i proračuna fizikalnih veličina sustava dati okvir za rješavanje složenih postojećih i budućih probleme u elektroenergetici. Prema pregledu literature navedeni pristup je tek u začetku primjene u promatranom području. Projektnim prijedlogom predlaže se istraživanje mogućnosti kosimulacije računalnih programa specijaliziranih posebno za simulacije distributivnih mreža i elektromotornih pogona i programa posebno specijaliziranih za metode mekog računarstva. Razvijene kosimulacijske procedure potrebno je uspješno primijeniti za rješavanje specifičnih problema u području distributivnih i industrijskih mreža opisanih u ciljevima projektnog prijedloga. Svrha znanstveno-istraživačkog projekta opisanog projektnim prijedlogom je osposobljavanje istraživačke grupe za primjenu robusnih metoda mekog računarstva u elektroenergetici.]]></summary_hr><summary_en><![CDATA[The most recent topics form the electrical grid and drives research field are focused on problems regarding renewable power sources, self-sustained power grids (micro grids), advanced (smart, intelligent) systems and energy efficiency improvement. To solve the problems that occur in practice and research many planning and system management simulation’s need to be completed. Accurate physical models and less time-consuming procedures are needed to further evolve the electrical system. In contrary, accurate modelling leads to high mathematical complexity of the model that limits the usability of the classical approach to solving problems. Adapting soft computing methods to problems in power engineering opens the possibility to increase the quality of the simulations while reducing time consumption. The application of these methods is developing fast with the rapid evolution of computer science, software and hardware. Recent literature reports high robustness of soft computing in practice.The proposed project main objective is development of synergy (co-simulation) algorithms for soft computing and system physical quantities calculation giving the framework for solving complex existing and future problems in power engineering.According to the literature, the mentioned approach to solving problems is still unexplored. Project proposal suggests research of the co-simulation possibilities of the specialized soft computing software with the electrical grid and drives simulation software. The developed co-simulation procedures need to be successfully implemented for solving specific problems in the field of distributive and industrial grids described in the project proposal.The scientific research project goal is to form a qualified research group for application of soft computing methods in power engineering.]]></summary_en></project><project>
<id>6865</id><title_hr><![CDATA[Emulacija analognih sustava u stvarnom vremenu]]></title_hr><title_en><![CDATA[Towards cost-effective real-time emulation of analog systems]]></title_en><user_id>13699</user_id><user_firstLast_name>Vladimir Čeperić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2017-05</proposal_call><code>UIP-2017-05-1900</code><acronim><![CDATA[EMUAN]]></acronim><duration>01.06.2018 - 31.05.2023</duration><status>Prekinut</status><financ_value>214.230,19 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Elektrotehnika, </scie_field_hr><scie_field_en>Electrical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id>26443, </team_members_id><team_members_names><![CDATA[Alma Traživuk, ]]></team_members_names><keywords_hr><![CDATA[Emulacija, simulacija, modeliranje, hardverska simulacijska petlja, FPGA]]></keywords_hr><keywords_en><![CDATA[Emulation, simulation, modeling, hardware-in-the-loop, FPGA]]></keywords_en><summary_hr><![CDATA[Glavni cilj projekta je razviti novi tip emulacije analognih nelinearnih sustava u stvarnom vremenu uvođenjem distribuiranog načina simulacije po događaju.Predloženi pristup omogućit će potpunu virtualizaciju analognog hardvera. Hardver koji treba opisati, modelirati i emulirati na brz način zamjenjuje se modelom koji se izvodi u realnom vremenu na cjenovno povoljnim FPGA ili mikrokontrolerskim platforama.Postoje brojne primjene predloženog rješenja npr. u automobilskoj industriji, industriji infrastrukturne opreme, radara, robotici, energetskih sustava, udaljenih sustava poput platformi, industriji poluvodiča i integriranih sklopova, javnim komunalnim uslugama i mnogim drugim.]]></summary_hr><summary_en><![CDATA[The main objective of this project is to revolutionize the hardware emulation by introducing a decentralized, event-driven way of simulating analog non-linear systems in the digital domain in real time on commodity hardware.The proposed approach will enable full virtual prototyping of analog non-linear hardware. Such hardware is replaced by the model which runs in real-time on a cost-effective FPGA platform or a micro-controller board.There are numerous applications of the proposed system in the automotive industry, infrastructure equipment industry, radar-related industry, robotics, power systems, off-shore systems, integrated-circuits related, public utility and many other. ]]></summary_en></project><project>
<id>6868</id><title_hr><![CDATA[Glikozilacija serumskog transferina kao faktor u mehanizmu prijenosa željeza]]></title_hr><title_en><![CDATA[Glycosylation as a factor in the iron transport mechanism of human serum transferrin]]></title_en><user_id>4009</user_id><user_firstLast_name>Tin Weitner</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2017-05</proposal_call><code>UIP-2017-05-9537</code><acronim><![CDATA[GlyMech]]></acronim><duration>01.02.2018 - 31.01.2023</duration><status>Prekinut</status><financ_value>284.955,87 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, Biologija, </scie_field_hr><scie_field_en>Chemistry, Biology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Farmaceutsko-biokemijski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Pharmacy and Biochemistry]]></institution_en><team_members_id>5548, 25197, 26503, </team_members_id><team_members_names><![CDATA[Ivan Biruš, Tomislav Friganović, Valentina Borko, ]]></team_members_names><keywords_hr><![CDATA[željezo, transferin, glikozilacija, ravnoteža, kinetika, mehanizam]]></keywords_hr><keywords_en><![CDATA[iron, transferrin, glycosylation, equilibrium, kinetics, mechanism]]></keywords_en><summary_hr><![CDATA[Projekt obuhvaća temeljno istraživanje utjecaja glikozilacije transferina, glavnog prenositelja željeza u ljudskom organizmu, na ravnotežu i kinetiku vezivanja željeza. Znanstveni ciljevi ovog projekta su: 1. određivanje konstanata ravnoteže vezivanja željeza za različite glikoforme transferina, 2. određivanje redukcijskog potencijala željeza vezanog u različitim glikoformama transferina te 3. određivanje kinetike i mehanizma vezanja i otpuštanja željeza iz različitih glikoformi transferina.Većina transferina su topljivi glikoproteini koji se sastoje od jednog lanca sa 700 aminokiselinskih ostataka i glikanskog dijela heretogene strukture i različitog sadržaja sijalinske kiseline. Tijekom fizioloških ili patofizioloških promjena u organizmu dolazi do post-translacijskih promjena u glikozilaciji transferina, pri čemu udio nesijaliniziranog transferina postaje značajno povišen. Promjene u razmjerno velikom glikanskom dijelu transferina mogu imati značajan utjecaj na konstantu vezivanja željeza te na vezivanje za transferinski receptor ciljnih stanica. Mehanizam vezivanja i otpuštanja željeza povezan je s njegovim redukcijskim potencijalom koji ovisi o različitim faktorima (npr. pH, sinergijski anion, itd.), a promjenom glikozilacije transferina također može doći i do značajne promjene redukcijskog potencijala te promjena u kinetici vezivanja ili otpuštanja željeza.Projekt osigurava preduvjete za znanstvenu izvrsnost i razvoj samostalnih istraživačkih karijera mladih znanstvenika poboljšanjem uvjeta rada u smislu opreme i drugih resursa te uklanjanja prepreka njihovoj mobilnosti. Provedbom projekta također će ojačati njihov kapacitet za povlačenje financijskih sredstava iz fondova EU i ostalih financijskih izvora te omogućiti održivost i proširenje znanstvene djelatnosti uspostavljene grupe.]]></summary_hr><summary_en><![CDATA[The proposed fundamental research of transferrin, the principal iron-transporting protein in the human body, and the impact of its glycosylation pattern on the equilibrium and kinetics of iron binding has the following scientific objectives: 1. determination of the iron-binding equilibrium constants for transferrin glycoforms, 2. determination of the reduction potential of iron bound to transferrin glycoforms, and 3. determination of the kinetics and mechanism of iron binding and release from transferrin glycoforms.Most transferrins are soluble glycoproteins consisting of a single chain of 700 amino acid residues and heterogeneous glycan structures. Physiological or pathophysiological changes in the organism lead to post-translational changes in the glycosylation of transferrin, resulting in the significantly increased levels of desialylated transferrin. Changes in relatively large glycan structures of transferrin may have a significant effect on the iron-binding constant and may also affect binding to the target cell receptors. The iron binding and release mechanism is associated with its reduction potential that depends on various factors (e.g. pH, synergic anion, etc.). Any alteration of the transferrin glycosylation pattern can result in changes in the reduction potential as well as the kinetics of iron binding or release.This project will facilitate scientific excellence and development of independent research careers of young scientists by increasing employment and improving their working conditions in terms of equipment and other resources or by removing obstacles to their mobility. Implementation of the project will also strengthen the capacity of young scientists to withdraw financial resources from EU funds and other sources and thus ensure the sustainability and expansion of the established research group’s scientific activity.]]></summary_en></project><project>
<id>6869</id><title_hr><![CDATA[Grupa za primijenjenu ultrabrzu spektroskopiju i fotokemijsku identifikaciju]]></title_hr><title_en><![CDATA[Group for Applied ultrafast Spectroscopy and Photochemical Identification]]></title_en><user_id>2622</user_id><user_firstLast_name>Silvije Vdović</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2017-05</proposal_call><code>UIP-2017-05-5831</code><acronim><![CDATA[GASPI]]></acronim><duration>01.03.2018 - 31.08.2023</duration><status>Završio</status><financ_value>178.591,81 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, Kemija, </scie_field_hr><scie_field_en>Physics, Chemistry, </scie_field_en><institution_hr><![CDATA[Institut za fiziku]]></institution_hr><institution_en><![CDATA[Institute of Physics in Zagreb]]></institution_en><team_members_id>4129, 12365, 22526, 25339, 865210, </team_members_id><team_members_names><![CDATA[Mario Rakić, Damir Dominko, Antonija Husak, Mateo Forjan, Vedran Brusar, ]]></team_members_names><keywords_hr><![CDATA[ultrabrza spektroskopija, fotofizika, fotokemija, tjerani fenomeni, nelinearna optika]]></keywords_hr><keywords_en><![CDATA[ultrafast spectroscopy, photophysics, photochemistry, driven phenomena, nonlinear optics]]></keywords_en><summary_hr><![CDATA[Cilj ovog projekta je uspostava nove istraživačke grupe koja će se fokusirati na proučavanje fotokemijskih procesa korištenjem metoda ultrabrze spektroskopije. Tranzijentna apsorpcija (TA) otkriva dinamiku promatranjem vremenskog razvoja sistema na potencijalnoj plohi pobuđenog stanja. Fotoinducirani procesi kao što su fotodisocijacija, fotoizomerizacija, prijenos energije i slični započinju apsorpcijom zračenja iz pumpne zrake. Pobuđena populacija prelazi na potencijalnu plohu pobuđenog stanja na kojoj se odvijaju fotoinducirani procesi. Probni puls zatim međudjeluje s pobuđenom molekulom te biva apsorbiran uzrokujući apsorpcijski spektar. Transfer populacije kroz međustanja može se pratiti uzimanjem TA spektara za niz vremenskih pomaka unutar vremenskog prozora od interesa. Kako bi se izvuklo što više korisnih informacija o tijeku fotoinduciranog procesa potrebna je pažljiva analiza TA spektara, što je često vrlo zahtijevan posao. Za otkrivanje procesa odgovornih za opažene spektralne promjene obično se koristi globalna analiza bazirana na određenom modelu. Rezultat prilagodbe su kinetički profili i pridruženi spektri zajedno sa konstantama rata. Ovim projektom unaprijeđeni eksperimentalni postav zasnovan na postojećem laserskom sustavu omogućiti će visoku vremensku rezoluciju te detekciju vrlo malih promjena tranzijentnih spektara. Eksperimentalni postav za tranzijentnu apsorpciju primijenti će se na istraživanje mehanizma fotokemijske reakcije nastajanja kinon-metida (QM) iz derivata fenola, naftola i antrola u fotokemijskoj reakciji dehidratacije. Važnost ovog istraživanja temelji se na činjenici da QM alkiliraju i križno spajaju lance DNA na temelju čega se zasniva antiproliferativno djelovanje nekih antitumorskih antibiotika. Također, dio projekta vezan je uz istraživanja tjeranih nelinearnih fenomena u sustavima s izraženim elektron-fonon vezanjem tehnikama ultrabrze spektroskopije koje su bazirane na detekciji signala pomoću Fourier transformacija.]]></summary_hr><summary_en><![CDATA[The aim of this project is to establish a new research group that will focus on investigation of photochemical processes using ultrafast spectroscopy methods. Monitoring of the ultrafast dynamics in complex molecular systems relies on pump – probe measurements with ultrashort pulses. Photo-induced processes like photodissociation, photoisomerisation, energy transfer and similar start with absorption of radiation from the pump beam. The population is then transferred to the upper potential energy surface where photo-induced process takes place. Probe pulse, following the pump pulse at some time delay, is absorbed by the molecule to form an absorption spectrum. The population transfer through intermediate states is then traced by taking the transient absorption (TA) spectrum at time delays within the time interval of interest. In order to extract as much information as possible, a careful analysis of TA spectra is needed, which can be quite tedious. To unravel processes underlying the observable spectroscopic changes, model-based global analysis is usually employed. As a result, kinetic profiles and associated spectra for the resolved components are obtained, together with rate constants. In this project, upgrade of a experimental equipment will enable high temporal resolution and detection of very small changes in transient spectra. The transient absorption setup will be used for investigation of mechanism of quinon methide (QM) generation from the phenol, naphthol and anthrol derivatives in photochemical reaction of dehydration. The importance of this research lies in the fact that QM alkylate and cross-link DNA chains which is the basis for antiproliferative activity of some antitumor antibiotics. In addition, one separate segment of the project is related to investigation of driven, nonlinear phenomena in systems with strong electron-phonon coupling using ultrafast Fourier transform spectroscopy techniques. ]]></summary_en></project><project>
<id>6880</id><title_hr><![CDATA[Rotavirusi u ekosustavu Republike Hrvatske: molekularna epidemiologija i zoonotski potencijal]]></title_hr><title_en><![CDATA[Rotaviruses in Croatian Ecosystem: molecular epidemiology and zoonotic potential]]></title_en><user_id>2597</user_id><user_firstLast_name>Dragan Brnić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2017-05</proposal_call><code>UIP-2017-05-8580</code><acronim><![CDATA[REco]]></acronim><duration>01.04.2018 - 31.03.2023</duration><status>Završio</status><financ_value>319.122,66 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo, Prirodne znanosti, </scie_area_hr><scie_area_en>Biomedicine and health sciences, Natural sciences, </scie_area_en><scie_field_hr>Veterinarska medicina, Biologija, Javno zdravstvo i zdravstvena zaštita, </scie_field_hr><scie_field_en>Veterinary medicine, Biology, Public health and health services, </scie_field_en><institution_hr><![CDATA[Hrvatski veterinarski institut]]></institution_hr><institution_en><![CDATA[Croatian Veterinary Institute]]></institution_en><team_members_id>22596, 2543, 25601, 862758, 865085, </team_members_id><team_members_names><![CDATA[Ines Škoko, Nina Krešić, Željko Pavlinec, Rok Kogoj, Valentina Kunić, ]]></team_members_names><keywords_hr><![CDATA[Rotavirus, ekosustav, Republika Hrvatska, NGS, virusna metagenomika, cijeli genom, genotip ]]></keywords_hr><keywords_en><![CDATA[Rotavirus, Ecosystem, Croatia, NGS, viral metagenomics, whole genome, genotype]]></keywords_en><summary_hr><![CDATA[Rotavirusi, a posebno vrsta Rotavirus A (RVA), su široko rasprostranjeni uzročnici crijevnih infekcija visoke prevalencije i patogenosti u ljudi i različitih vrsti životinja. Dokazi učestalog križanja evolucije humanih i životinjskih  rotavirusa su do sada puno puta opisani. Međutim istraživanja životinjskih RVA sojeva znatno zaostaju za humanim, a naročito istraživanja sojeva podrijetlom od divljih životinja. Stoga je glavni cilj ovog projekta provesti sinkroniziranu prostorno-vremensku molekularnu epidemiološku studiju kako bi se procijenio zoonotski potencijal autohtonih rotavirusa A u ekosustavu Republike Hrvatske, slijedeći pri tome pristup „Jedno zdravlje? (One Health). Naša multidisciplinarna ideja istraživanja donosi cjelovitost i sveobuhvatnost, a takav usklađeni pristup veterinarske i humane medicine se smatra nužnim. Odabrana metodologija će nam pružiti jedinstvenu prigodu bolje upoznati genomsku strukturu, genotipski sastav genoma, filogenetsku srodnost i zoonotski potencijal hrvatskih autohtonih sojeva RVA istovremeno utvrđenih u domaćih i divljih životinja, u ljudi te okolišu. Povrh toga, NGS tehnologija primijenjena u postupku sekvenciranja cijelog genoma RVA će pri tome razotkriti raznolikost virusnog metagenoma u ekosustavu Republike Hrvatske, ali i moguće nove virusne prijetnje od javno-zdravstvenog značaja. Ovo istraživanje će po prvi puta definirati strukturu cijelog genoma RVA podrijetlom od nekoliko vrsti divljih životinja te donijeti novi pogled na njihovu evoluciju i sposobnost za pojavljivanje u populacijama ljudi i domaćih životinja. Novoosnovana autohtona RVA virusna banka će  zajedno s genotipskim bazama podataka omogućiti ubrzano genetsko praćenje novih emergentnih zoonotskih RVA sojeva. Ovim projektnim prijedlogom ćemo osnovati REco istraživačku skupinu s ciljem jačanja znanja, umrežavanja i konkurentnosti svakog člana u Europskom istraživačkom prostoru što će u konačnici rezultirati novim suradničkim istraživačkim inicijativama.]]></summary_hr><summary_en><![CDATA[Rotaviruses, especially the species Rotavirus A (RVA), are worldwide distributed enteric pathogens with high prevalence and pathogenicity in humans and variety of animals. The evidence for frequent intersections between the evolution of human and animal RVAs has been well documented. However the research on animal RVA strains is significantly lagging, especially on strains originating in wildlife. Therefore, the main aim of this project is to conduct a synchronized spatiotemporal molecular epidemiology study in order to assess the zoonotic potential of autochthonous RVA in Croatian ecosystem, by following the One Health concept. Our multidisciplinary research idea brings integrity and comprehensiveness in its approach and such concerted effort at the interface of veterinary medicine and public health is considered as warranted. By means of selected methodology, we will have a unique opportunity to get a closer look into genomic structure, genotype constellation, phylogenetic relatedness and zoonotic potential of Croatian autochthonous RVA strains simultaneously detected in domestic and wild animals, humans and environment. Moreover, the NGS technology applied for RVA whole genome sequencing will additionally reveal the diversity of viral metagenomes present in Croatian ecosystem and potentially expose new viral threats of public health importance. This study will be the first one defining a genetic backbone of RVAs in several wildlife species and bring a novel perspective on RVA evolution and the capacity of wildlife RVAs for the emergence into human and domestic animal populations. An autochthonous RVA virus bank will be formed, along with genotype databases enabling future seamless genetic tracking of novel emerging zoonotic strains. This project proposal will install a REco research group with the aim to boost knowledge, networking and competitiveness of each team member in the European Research Area, resulting in future novel collaborative research initiatives.]]></summary_en></project><project>
<id>6881</id><title_hr><![CDATA[Zeleni modularni putnički brod za Mediteran]]></title_hr><title_en><![CDATA[Green Modular Passenger Vessel for Mediterranean]]></title_en><user_id>252</user_id><user_firstLast_name>Nikola Vladimir</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2017-05</proposal_call><code>UIP-2017-05-1253</code><acronim><![CDATA[ZEMP / GRiMM]]></acronim><duration>01.03.2018 - 31.07.2023</duration><status>Završio</status><financ_value>144.667,86 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Brodogradnja, Strojarstvo, </scie_field_hr><scie_field_en>Naval architecture, Mechnical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet strojarstva i brodogradnje]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Mechanical Engineering and Naval Architecture]]></institution_en><team_members_id>22527, 22651, 22745, 19119, 25261, 858374, </team_members_id><team_members_names><![CDATA[Ivica Ančić, Inno Gatin, Marina Tošić, Vuko Vukcevic, Maja Perčić, Ivana Jovanović, ]]></team_members_names><keywords_hr><![CDATA[putnički brod, modularni pristup, hidrodinamičke značajke, energetska učinkovitost, buka, vibracije ekološka prihvatljivost]]></keywords_hr><keywords_en><![CDATA[passenger vessel, modular approach, hydrodynamic characteristics, energy efficiency, noise, vibrations, environmental impact]]></keywords_en><summary_hr><![CDATA[Svrha projekta „Zeleni modularni putnički brod za Mediteran – ZEMP“ je razvoj nove metodologije projektiranja malih putničkih brodova namijenjenih za plovidbu Mediteranskim morem primjenom modularnog pristupa. Modularni pristup omogućava promjenu proizvodne paradigme od klasičnog pristupa u kojemu se sve komponente izrađuju u brodogradilištu prema paralelnoj proizvodnji različitih modula od strane kooperanata te završnoj montaži u brodogradilištima. Predviđeno je da se putnički broj sastoji od tri modula koji će činiti trup broda, brodski energetski sustav i nadgrađe. Kombinacijom tih modula mijenjat će se karakteristike broda, kao što su dimenzije, kapacitet, propulzijske značajke, pogonsko gorivo i razne inovativne energetski učinkovite tehnologije. Dakako, ovakav pristup povećava složenost procesa projektiranja jer je već u fazi projektiranja modula potrebno uzeti u obzir mnoštvo različitih značajki kojima koncepti trebaju udovoljavati, kao i pripadajući regulatorni okvir.U sklopu projekta najprije će biti provedena analiza tržišta za razna područja plovidbe unutar Mediterana kako bi se mogle odrediti potrebe kojima putnički brodovi trebaju udovoljiti. Na temelju toga će biti predloženo nekoliko preliminarnih koncepata, dok će finalni koncepti biti razvijeni uzimajući u obzir i sve druge aspekte projektiranja: hidrodinamičke i propulzijske značajke, jednostavnost procesa izrade, razinu ugode za putnike i posadu, kao i ekološki prihvatljiva rješenja energetskog sustava. Na temelju kriterija za pojedine namjene odabrat će se optimalni koncepti malog putničkog broda. Projekt će rezultirati predloženim konceptima koji će, ovisno o potrebama tržišta, imati niže troškove proizvodnje, povećanu razinu ugode za putnike i posadu, smanjenu potrošnju goriva i smanjeni utjecaj na okoliš.]]></summary_hr><summary_en><![CDATA[The objective of the project “Green Modular Passenger Vessel for Mediterranean – GRiMM” is the development of the new design methodology for small passenger ships aimed for the operation in the Mediterranean Sea, by applying the modular concept approach. The modular concept enables the change of the ship production paradigm from the classical all-in-one approach to a parallel manufacture of different components done by highly specialized producers and a final assembly done by the local shipyard. The target vessel is considered as made of independent modules which can be combined together to achieve different characteristics in terms of ship dimensions, carrying capacity, operating conditions, fuel options and innovative energy efficient solutions. Fundamentally, the ship is made of three modules forming the ship hull, power system and superstructure. Of course this approach makes the design process much more complex than that for a single specific ship, as it has to account for all the different needs and for the associated regulatory aspects.First, an analysis of the market needs and of the corresponding ship requirements will be performed for different navigation regions in the Mediterranean Sea. Preliminary concepts based on that analysis will be proposed, while the final concepts will be developed taking into account all the aspects of ship design: hydrodynamic and propulsion efficiency, simplified manufacturing processes, ship habitability (comfort level for crew and passengers) as well as environmentally friendly energy solutions. Through this project several optimized modular passenger vessels will be proposed depending on the selected design criteria sets. In this sense it is expected that the project will result in a number of concepts depending on the market needs with reduced production costs, higher level of comfort for crew and passengers, reduced fuel consumption as well as lower environmental impact.]]></summary_en></project><project>
<id>6882</id><title_hr><![CDATA[Internet stvari: istraživanja i primjene ]]></title_hr><title_en><![CDATA[Internet of Things: Research and Applications]]></title_en><user_id>7605</user_id><user_firstLast_name>Petar Šolić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2017-05</proposal_call><code>UIP-2017-05-4206</code><acronim><![CDATA[IoTRA]]></acronim><duration>19.03.2018 - 18.09.2023</duration><status>Završio</status><financ_value>277.060,09 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Elektrotehnika, Računarstvo, </scie_field_hr><scie_field_en>Electrical engineering, Computer sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Splitu, Fakultet elektrotehnike, strojarstva i brodogradnje]]></institution_hr><institution_en><![CDATA[University of Split, Faculty of Electrical Engineering, Mechanical Engineering and Naval Architecture]]></institution_en><team_members_id>22801, 2623, 7189, 25802, 28922, 865206, 866660, </team_members_id><team_members_names><![CDATA[Toni Perković, Duje Čoko, Maja Škiljo, Ana Čulić, Lea Dujić Rodić, Kristina Zovko, Ana Grubišić, ]]></team_members_names><keywords_hr><![CDATA[Internet stvari, RFID, uređaji niske potrošnje, pametna okruženja, prototipiranje uređaja]]></keywords_hr><keywords_en><![CDATA[Internet of Things (IoT), RFID, Low Power Devices, Smart Environemnt, Device Prototyping]]></keywords_en><summary_hr><![CDATA[Internet stvari je postala najistraživanija tema u području elektrotehnike i računarstva. Postojeće tehnološke infrastrukture se trenutno redizajniraju s ciljem organizacije mrežnih arhitektura potrebnih za komunikaciju milijardi uređaja u realnom vremenu, pohrane velike količine podataka i korištenja istih za izgradnju budućih pametnih okruženja. Posljedično, pojavit će se nove usluge i tehnologije koje će olakšati život.Cilj ovog projektnog prijedloga odgovara temi vizije Interneta stvari, a omogućava  smanjenje robusnosti i energetskih zahtjeva IoT uređaja, održivost i što je najvažnije primjenjivost u skoroj budućnosti. Temeljem zapaženih nedostataka postojeće tehnologije, cilj je dati nove prijedloge koje smanjuju ograničenja, te koriste stečena znanja s ciljem izrade prototipova poboljšanih uređaja. Kao posljedica, izraditi će se skupina novih poboljšanih prototipova testiranih u realnim uvjetima koje omogućuju takvu viziju.]]></summary_hr><summary_en><![CDATA[Internet of Things (IoT) became the hottest research topic in the field of electronics and computer science. New upcoming technological infrastructures are currently being redesigned in order to handle real time communication between billions of devices, storing their big data, analyzing and using the data to manipulate the future smart environments. Consequently, new services and technologies will emerge, and help in making life easier.The aim of this proposal goes in-line with the hottest research topics enabling IoT vision, while proposing new advances that make IoT technology less robust, less expensive, less power hungry, sustainable and the most important, applicable in the close future. In particular, the proposal is oriented toward gathering the state of the art IoT enabling technologies available on the market in order to provide in-depth analysis of their performances. Based on the noticed disadvantages of state of the art technologies, the goal is to provide new proposals that can enhance limitations, bring new related insights and use acquired knowledge to construct prototypes of these new enhanced devices. As a consequence, a set of new robust prototypes tested in real environments that can help in accomplishing such vision will be provided. ]]></summary_en></project><project>
<id>6883</id><title_hr><![CDATA[Razvoj novih membrana za ionsko-selektivne elektrode s dodatkom nanočestica metala i metalnih oksida]]></title_hr><title_en><![CDATA[Development of new membranes for ion-selective electrodes enriched with nanoparticles of metals and metal oxides]]></title_en><user_id>13403</user_id><user_firstLast_name>Ante Prkić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2017-05</proposal_call><code>UIP-2017-05-6282</code><acronim><![CDATA[NANOISEM]]></acronim><duration>01.03.2018 - 28.02.2023</duration><status>Završio</status><financ_value>150.954,94 eur</financ_value><scie_area_hr>Prirodne znanosti, Biotehničke znanosti, Biomedicina i zdravstvo, Tehničke znanosti, </scie_area_hr><scie_area_en>Natural sciences, Biotechnical sciences, Biomedicine and health sciences, Technological sciences, </scie_area_en><scie_field_hr>Kemija, Kemijsko inženjerstvo, Biotehnologija, Biotehnologija u biomedicini, </scie_field_hr><scie_field_en>Chemistry, Chemical engineering, Biotechnology, Biotechnology in Biomedicine, </scie_field_en><institution_hr><![CDATA[Sveučilište u Splitu, Kemijsko-tehnološki fakultet]]></institution_hr><institution_en><![CDATA[University of Split, Faculty of Chemistry and Technology]]></institution_en><team_members_id>13512, 5300, 1163, 22685, 22703, 22736, 25093, </team_members_id><team_members_names><![CDATA[Perica Bošković, Ivana Opačak, Miće Jakić, Anamarija Veljacic Veljacic, Tina Vukušić, Karmela  Zankli Kulazo, Andrea  Sedlar, ]]></team_members_names><keywords_hr><![CDATA[Ionsko-selektivne elektrode, membrane, nanočestice, potenciometrija, senzori]]></keywords_hr><keywords_en><![CDATA[Ion-selective electrodes, membranes, nanoparticles, potentiometry, sensors]]></keywords_en><summary_hr><![CDATA[Cilj projektnog prijedloga je razvoj višenamjenskih potenciometrijskih senzora u čvrstom stanju s membranama uz dodatak nanočestica metala, odnosno metalnih oksida te mikroemulzijskih gel membrana. Sekundarni cilj je razviti jednostavne potenciometrijske senzore za određivanje kemijskih vrsta od interesa (npr. kromovih specija u otpadnim vodama poslije kromiranja; kloridnih iona u prehrambenim proizvodima i sl.) koji će imati poboljšana svojstva. Poboljšana svojstva senzora očitovat će se u jednostavnijoj pripremi uzoraka za analizu (ne smeta obojenje i mutnoća uzorka), poboljšana kemijska, fizikalna i električna svojstva što će izravno poboljšati robustnost, povećati linearno dinamičko područje odziva, poboljšati vrijeme odziva, produžiti životni vijek senzora, omogućiti kontinuirano mjerenje u realnom vremenu, smanjiti troškove analize smanjenjem količine otopina čime se smanjuje i količina štetnih otpadnih kemikalija. Potom razvoj novih on-line i in-line analitičkih metoda za određivanje analita od interesa, što će poboljšati standardnu analitičku metodologiju za određivanje odabranih vrsta poboljšanjem selektivnosti, osjetljivosti, stabilnosti i trajnosti senzora. Razvoj ionsko-selektivnih elektroda izvest će se na dva plana: izrada novih membrana dodatkom nanočestica i mikroemulzijskih gel membrana te izradom novog tijela elektrode s čvrstim kontaktom, minijaturizacijom u cilju pojednostavljenja procesa proizvodnje ionsko selektivnih elektroda, odnosno povećane primjenjivosti senzora posebice kod kontinuiranog praćenja procesnih uvjeta proizvodnje, direktnim smanjenjem troškova proizvodnje što će u konačnici voditi smanjenju troškova analize.]]></summary_hr><summary_en><![CDATA[The aim of the project proposal is the development of multifunctional potentiometric sensors in solid state with membranes with the addition of nano particles, and microemulsion gel membrane. A secondary objective is to develop simple potentiometric sensors for the determination of chemical species of interest that would have improved properties. Improved sensor performance will be based on simpler preparation of samples for analysis (does not matter discoloration and turbidity of the sample), improved chemical, physical and electrical properties. Mentioned properties will directly improve the robustness, increase the linear dynamic range response, improved response time, extended life sensors, allow continuous measurement in real time, lower the costs of the analysis by reducing the amount of solution, which reduces the amount of harmful waste chemicals. Then the development of new on-line and in-line analytical method for the determination of an analyte of interest, which will improve the standard analytical methodology for the determination of selected species by improving the selectivity, sensitivity, stability and durability of the sensor. The development of ion-selective electrodes will be performed by the development of new membrane with addition of nano particles and microemulsion gel membrane. Following step will be creation of a new body of the electrode with solid contact, miniaturization in order to simplify the manufacturing process of ion selective electrodes or increased applicability of sensors especially for the continuous monitoring of process conditions of production, direct reduction in production costs, which will ultimately lead to reductions in the cost analysis. ]]></summary_en></project><project>
<id>6891</id><title_hr><![CDATA[Mikrobiom glavate želve (Caretta caretta): uvid u epizoičke i endozoičke zajednice]]></title_hr><title_en><![CDATA[Loggerhead sea turtle (Caretta caretta) microbiome: insight into endozoic and epizoic communities]]></title_en><user_id>4337</user_id><user_firstLast_name>Sunčica Bosak</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2017-05</proposal_call><code>UIP-2017-05-5635</code><acronim><![CDATA[TurtleBIOME]]></acronim><duration>01.03.2018 - 31.08.2023</duration><status>Završio</status><financ_value>306.011,02 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Biologija, </scie_field_hr><scie_field_en>Biology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>17842, 19415, 25309, 855403, 858354, </team_members_id><team_members_names><![CDATA[Maja Mejdandžić, Romana Gračan, Klara Filek, Marta Zizek, Lucija Kanjer, ]]></team_members_names><keywords_hr><![CDATA[Mikrobiom, dijatomeje, morske kornjače, morska mikrobna ekologija, epizojske zajednice]]></keywords_hr><keywords_en><![CDATA[Microbiome, diatoms, sea turtles, marine microbial ecology, epizoic community  ]]></keywords_en><summary_hr><![CDATA[Mikrobiom predstavlja vitalni sustav koji se počeo razmatrati kroz paradigmu holobionta i opisivati kao cjelokupan sustav biljke/životinje zajedno s mikroorganizmima koji žive unutar ili na površini organizma. Morske kornjače su karizmatični morski kralješnjaci, među najugroženijim vrstama na svijetu. Nedavno je otkriveno da oklop morskih kornjača naseljavaju jedinstvene i brojne zajednice fotosintetskih mikroorganizama od kojih su najznačajnije dijatomeje. Jedinstvene vrste epibiontskih dijatomeja koloniziraju vanjske površine morskih kornjača, kožu i oklop, a novootkrivene epizoičke svojte pronađene su na svim vrstama morskih kornjača diljem svijeta. Unatoč važnosti i fundamentalnoj ulozi mikroorganizama u fiziološkim procesima morskih kornjača, u potpunosti nedostaju podaci o epibiontskim bakterijama,dok je sastav bakterijskih zajednica u probavilu samo sporadično opisan. Znanstveni doprinos predloženog projekta je pružiti jasnu sliku mikrobiološkog sastava površinskog biofilma i mikrobioma probavila glavatih želvi koje su najbrojnija vrsta morskih kornjača u Jadranu i Mediteranu. Kako bi ispunili zadani cilj koristiti ćemo najsuvremeniji molekularni pristup, ali i uhodane tradicionalne metode. Ovaj uspostavni istraživački projekt okuplja mlade i kompetentne znanstvenike u jedinstvenu sinergističku skupinu koja je sposobna postaviti temelj novom interdisciplinarnom istraživačkom pristupu u ekologiji i zaštiti mora te biologiji mora. Predloženi projekt će pružiti temeljne podatke o sastavu zajednica mikrobioma glavatih želvi koje će nadograditi postojeće znanje o ponašanju morskih kornjača, njihovim migracijskim putevima i staništima ishrane te pridonijeti dugotrajnim planovima zaštite morskih kornjača. Znanja prikupljena ovim projektom mogu se u budućnosti primijeniti za praćenje i zaštitu i drugih ugroženih morskih kralješnjaka poput dupina ili kitova, posebice jer će omogućiti nove spoznaje u svjetlu globalnih klimatskih promjena.]]></summary_hr><summary_en><![CDATA[The microbiome has become increasingly regarded as a vital system, currently viewed through paradigm of holobiont, describing the plant/animal together with the organisms living within or on their surface. Sea turtles are charismatic marine vertebrates and among the most endangered animals in the world. Recent findings show that sea turtles harbour unique and abundant epizoic microbial communities on their carapaces. Sea turtle-associated diatoms show ability to colonize the surface of animal tissues, both skin and carapace and new species/genera have been described worldwide from all sea turtle species. In spite of their importance and essential role in the host animal physiological functions there are huge knowledge gaps on the sea turtle holobiont. Our proposal aims to describe sea turtle microbial biodiversity by studying surface biofilm community and the gut microbiome of loggerhead turtles occurring in the Adriatic Sea. We will achieve this goal by pairing state-of-the-art culture-independent molecular approach with classic research methods. This installation research project aims to combine efforts of young and competent scientists in a single cohesive group that will set out the foundation for an interdisciplinary research approach in fields of marine ecology, marine biology and conservation. The proposed study will provide baseline data on the composition of loggerhead microbiome that might be integrated with the existing information on sea turtle behaviour, their migration routes, and foraging habitats thus contributing to a long term plans for sea turtle protection. Provided set of tools and methods may be applied in the future to other endangered marine animal-microbe associations in the rapidly changing world we live in.]]></summary_en></project><project>
<id>6896</id><title_hr><![CDATA[Prema pouzdanoj raspodijeljenoj upravljačkoj ravnini za programirljive komunikacijske mreže]]></title_hr><title_en><![CDATA[Towards Reliable Distributed Control Plane for Programmable Communication Networks]]></title_en><user_id>2572</user_id><user_firstLast_name>Ognjen Dobrijević</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2017-05</proposal_call><code>UIP-2017-05-1569</code><acronim><![CDATA[reCREATE]]></acronim><duration>01.03.2018 - 28.02.2023</duration><status>Prekinut</status><financ_value>108.697,86 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Elektrotehnika, Računarstvo, </scie_field_hr><scie_field_en>Electrical engineering, Computer sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id>4569, 3189, 22572, </team_members_id><team_members_names><![CDATA[Marija Furdek, Matija  Džanko, Haris Hodzic, ]]></team_members_names><keywords_hr><![CDATA[Virtualizacija mreže, programski upravljano umrežavanje, raspodijeljena upravljačka ravnina, mrežni hipervizor, pouzdanost, otpornost na kvarove]]></keywords_hr><keywords_en><![CDATA[Network virtualization, software-defined networking, distributed control plane, network hypervisor, reliability, failure resiliency]]></keywords_en><summary_hr><![CDATA[Komunikacijske mreže razvijaju se prema svojoj petoj generaciji, koja mora zadovoljiti stroge zahtjeve vezane uz raspoloživost usluga i komunikacijsko kašnjenje. Iz tih razloga, buduće mreže će se oslanjati na paradigme programski upravljanog umrežavanja (SDN) i virtualizacije mreže, za koje se predviđa da će unaprijediti prilagodljivost mreža. SDN je specifičan zbog odvajanja funkcija upravljanja mrežom iz uređaja podatkovne ravnine te njihove implementacije u vidu SDN upravljačkog uređaja (SDNC). Sa SDN-om, aplikacije treće strane mogu programirati mreže, pri čemu koriste otvorena sučelja izložena od strane SDNC-ova. Mrežni hipervizori omogućuju virtualizaciju apstrahiranjem mrežnih resursa u izolirane logičke segmente, pri čemu obavljaju i ulogu posrednika između više SDNC instanci i uređaja podatkovne ravnine. U takvim mrežama, osiguravanje otpornosti upravljačke ravnine na kvarove neophodan je preduvjet za ispravan rad mreže i njezinih usluga.Glavni znanstveni cilj ovog projekta je predložiti pristupe u projektiranju pouzdane SDN upravljačke ravnine koja obuhvaća više instanci SDNC-a i mrežnog hipervizora. U prvom dijelu istraživanja ispitat ćemo kritičnost komponenti upravljačke ravnine s obzirom na različite vrste kvarova i predložiti novu mjeru dostupnosti upravljačke ravnine. Zatim ćemo formulirati problem raspoređivanja upravljačkih uređaja i hipervizora, koji podrazumijeva otpornost na kvarove, te razviti optimizacijske algoritme za njegovo rješavanje. Rješenja tog problema određuju broj i fizičke lokacije instanci SDNC-a i mrežnog hipervizora, a pritom dodjeljuju dovoljno rezervnih resursa za slučaj pojava kvarova. U drugom dijelu istraživanja definirat ćemo model sinkronizacije stanja mreže za raspodijeljenu SDN upravljačku ravninu, kao i generičke postupke za upravljanje kvarovima. Svi predloženi pristupi eksperimentalno će se vrednovati u sklopu istraživačkog prototipa s modernom mrežnom opremom koja ima podršku za SDN.]]></summary_hr><summary_en><![CDATA[Communication networks are evolving towards their fifth generation, which needs to meet the rigorous requirements on service availability and communication latency. For these reasons, future networks will rely on the software-defined networking (SDN) and network virtualization paradigms, which are anticipated to enhance network flexibility. SDN is specific for its separation of the network control functions from data plane devices and then implementing the functions in an SDN controller (SDNC). With SDN, the networks are becoming programmable by third party applications, which utilize open interfaces exposed by SDNCs. Network hypervisors enable virtualization by abstracting network resources into isolated logical segments and by acting as mediators between multiple SDNC instances and data plane devices. In such networks, ensuring the control plane resilience to failures is an essential precondition for the accurate operation of the network and its services.The main scientific objective of this project is to propose approaches for the design of a reliable SDN control plane that encompasses multiple SDNC and network hypervisor instances. In the first research track, we will examine the criticality of control plane components against different failure types and specify a novel control plane availability measure. Then, we will formulate the controller and hypervisor placement problem that considers resilience to failures and develop optimization algorithms to solve it. The problem solutions determine the number and physical locations of SDNC and network hypervisor instances, while also allocating adequate backup resources in case of failures. In the second research track, we will specify a network state synchronization model for the distributed SDN control plane, as well as generic control procedures for dealing with failures. All the proposed approaches will be experimentally evaluated on a research testbed with the modern SDN-supported networking equipment.]]></summary_en></project><project>
<id>6897</id><title_hr><![CDATA[Neonikotinoidi i bakar u mediteranskoj poljoprivredi – učinci na neciljanu faunu beskralješnjaka kroz trofičke interakcije]]></title_hr><title_en><![CDATA[Neonicotinoids and Copper in the Mediterranean Agriculture - their effects on non-target invertebrates through trophic interactions]]></title_en><user_id>12919</user_id><user_firstLast_name>Lucija Šerić Jelaska</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2017-05</proposal_call><code>UIP-2017-05-1046</code><acronim><![CDATA[MEDITERATRI]]></acronim><duration>01.03.2018 - 31.08.2023</duration><status>Završio</status><financ_value>264.803,90 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Biologija, Kemija, </scie_field_hr><scie_field_en>Biology, Chemistry, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>12409, 12892, 25091, 28927, </team_members_id><team_members_names><![CDATA[Tomislav Kos, Mišel Jelić, Barbara  Anđelić , Lara Ivanković, ]]></team_members_names><keywords_hr><![CDATA[korisna fauna beskralješnjaka, mediteranska ekosustavi, održivo upravljanje, trofičke mreža, trčci,pauci, štrige]]></keywords_hr><keywords_en><![CDATA[Beneficial invertebrate fauna, Mediterranean ecosystems, sustainable management, trophic network, carabids, spiders, centipedes]]></keywords_en><summary_hr><![CDATA[Neonikotinoidi su relativno novi i najčešće korišteni insekticidi u svijetu. Za razliku od njih, primjena bakra (Cu) ima dugu povijest u zaštiti bilja, osobito u mediteranskoj poljoprivredi (npr. u vinogradima). Novija istraživanja su pokazala brojne negativne učinke na vrste koje nisu cilj djelovanja pesticida (npr. gujavice, ptice) i ukazala na problem očuvanja vrsta korisnih u biološkoj kontroli kao što su predatori (npr. kornjaši trčci, pauci i štrige) koji su ujedno ključni za pravilno funkcioniranje ekosustava. Velika biološka raznolikost u tlu i složene trofičke interakcije nisu dovoljno istražene i stoga je teško predvidjeti sve moguće negativne učinke pesticida. Slabo poznavanje hranidbenih lanaca kod beskralješnjaka dijelom je posljedica ograničenih mogućnosti koje nude tradicionalne metode poput mikroskopskog pregleda. Detaljne trofičke analize danas su moguće pomoću najnovijih molekularnih tehnika kao što je nova generacija sekvenciranja (NGS). Cilj ovog istraživanja je utvrditi trofičke odnose na terenu analizom probavila predatora beskralješnjaka, utvrditi vektore za prijenos pesticida putem ishrane te izravan utjecaj primjene pesticida na preživljavanje i raznolikost predatora i plijena. Terensko istraživanje obavit će se u mediteranskim poljoprivrednim ekosustavima, vinogradima i maslinicima, gdje se koriste oba pesticida, te u prirodnom staništu bez gospodarenja. NGS-om će se utvrditi kompletna ishrana predatora i ujedno će se generirati podaci o DNA sljedovima za brojne vrste beskralježnjaka koji će biti pohranjeni u bazama projekta &#39;&#39;The International Barcode of Life&#39;&#39;. LC-MS / MS i ICP-MS tehnikom kvantificirat će se ostatci neonikotinoida i izmjeriti koncentracije Cu u tlu i životinjama na različitim trofičkim razinama. Rezultati će uvelike doprinijeti procjeni rizika primjene i širenja neonikotinida i Cu u ekosustavu te znanju o održivosti  beskralješnjaka predatora kao ključne skupine u integriranoj zaštiti bilja u poljoprivredi.]]></summary_hr><summary_en><![CDATA[Neonicotinoids are the most commonly used insecticides worldwide, and are relatively new, whereas application of Copper (Cu) has a long history, especially in the Mediterranean agriculture, (e.g. in vineyards). Recent studies have shown their negative effects on non-target species (e.g. earthworms, insects, birds) and raised great concerns about survival of beneficial predatory species (e.g. carabid beetles, spiders and centipedes), important for pest control and essential for healthy ecosystem functioning. High biodiversity in the soil and very complex food webs are far from being well explored and thus it is hard to predict all possible negative effects of pesticides. This knowledge gap reflects, in part, the fact that traditional methods such as microscopic inspection cannot detect many trophic interactions. Recently, complex food web analysis has become possible with the advent of molecular techniques as Next Generation Sequencing NGS. By analysing trophic interactions of soil invertebrates, the aim is to identify vectors that transfer toxicant to general predators and to connect application of pesticides with the predator and prey survival and diversity in the field. Field survey will take place within Mediterranean agriculture ecosystems, in vineyards and olive orchards, treated with both pesticides and in pristine habitat. NGS will be used to reveal the complete diet of predatory invertebrates in the field. Besides, it will generate valuable DNA sequence data for numerous invertebrate species that will be deposited in “The International Barcode of Life“ databases. LC-MS/MS and ICP-MS technique will quantify neonicotinoid residues and Cu concentrations in soil and in animals representing different trophic guilds. The results will greatly contribute to the risk assessment of neonicotionid and copper proliferation in the ecosystem and to the knowledge on the overall field sustainability of predatory invertebrates, a key group in integrated pest control.]]></summary_en></project><project>
<id>6899</id><title_hr><![CDATA[Višerazinski pristup govornom diskursu u jezičnom razvoju]]></title_hr><title_en><![CDATA[Multilevel approach to spoken discourse in language development]]></title_en><user_id>6147</user_id><user_firstLast_name>Gordana Hržica</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2017-05</proposal_call><code>UIP-2017-05-6603</code><acronim><![CDATA[MultiDis]]></acronim><duration>01.01.2018 - 31.12.2023</duration><status>Završio</status><financ_value>131.404,87 eur</financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Logopedija, </scie_field_hr><scie_field_en>Logopedics, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Edukacijsko-rehabilitacijski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Education and Rehabilitation Sciences]]></institution_en><team_members_id>22675, 22678, 3664, 17791, 22665, 25250, 20102, 25249, 23925, 27955, 5121, </team_members_id><team_members_names><![CDATA[Gordana Dobravac, Nada Poropat Jeletić, Tomislava Bošnjak Botica, Marina Olujić, Marina Camber, Sara Košutar, Ivana Trtanj, Eliana Moscarda Mirković, Ana Leko Krhen, Matea Kramarić, Katarina Aladrović Slovaček, ]]></team_members_names><keywords_hr><![CDATA[govorni diskurs, jezični razvoj, mjere za procjenu diskursa, višerazinski pristup, dvojezični govornici, narušen jezični razvoj, SES]]></keywords_hr><keywords_en><![CDATA[spoken discourse, language development, measures for discourse assessment, multi-level approach, bilingualspeakers, atypical language development, SES]]></keywords_en><summary_hr><![CDATA[U psiholingvistici i primijenjenoj lingvistici procjena proizvedenog diskursa smatra se pouzdanim sredstvom procjene jezičnog znanja (Schneider i sur., 2006; Botting, 2002). Prikupljanje diskursnih uzoraka ekološki je valjano sredstvo procjene jer odražava uporabu jezika u svakodnevnom okruženju. Među različitim pristupima diskursu ističe se višerazinski pristup. Ovaj je pristup teorijska smjernica projektnog prijedloga, iako do sada nije bio primijenjen na područje jezičnog razvoja. Većina se teorija i mjera analize diskursa temelje na engleskom jeziku zbog čega postoji potreba za validacijom podatcima iz tipološki različitih jezika. U ovom projektu za istraživanja će se koristiti postojeći resursi, ali i nadopuniti ili u potpunosti razviti novi (leksičke baze i korpusi). Spoznaje koje će biti rezultat analize tih resursa, poput onih o pojavnosti i čestotnosti različitih struktura u hrvatskom jeziku u određenom razvojnom periodu kod različitih populacija, kao i prilagodbom automatiziranih korpusnih mjera hrvatskome, stvorit će se preduvjeti za razvoj novog materijala za poticanje proizvodnje diskursa. Materijal će se temeljiti na slikovnim predlošcima te će se rabiti računalno uz automatizaciju snimanja, podršku pri transkripciji te izračun mjera za procjenu diskursa. Zbog temeljenosti na prethodnim istraživanjima te psihometrijskih karakteristika materijal će se moći rabiti za jezičnu procjenu, a validacijsko će ispitivanje pružiti pouzdane podatke o razvoju diskursa za različite skupine govornika (jednojezični, dvojezični, narušen jezični razvoj, različit SES) u višerazinskom pristupu.Očekuje se da će se ovim pristupom u projektu a. steći uvid u kognitivne i jezične aspekte ključne za oblikovanje diskursa, b. doprinijeti međunarodnim znanstvenim teorijama i pristupima, c. razviti ili nadopuniti te učiniti javno dostupnima jezične resurse pogodne za druga lingvistička istraživanja te d. doprinijeti spoznajama područjima jezičnog obrazovanja i jezične procjene.]]></summary_hr><summary_en><![CDATA[In the field of psycholinguistics and applied linguistics, discourse analyses have been considered a valuable tool for assessing language knowledge (Schneider et al., 2006; Botting, 2002). The elicitation of discourse samples is an ecologically valid assessment tool since it reflects conversation in everyday environment. A multi-level approach is the main framework of this project proposal. Most of the theories, approaches and discourse analyses measures are based on English language so there is a need for their validation in typologically different languages. In this project new resources will be developed and some existing updated (i.e., lexical database and different corpora). Their analyses will lead to new findings, such as frequency and types of language structures in Croatian in a particular period during language development and in different populations, as well as to development of new automatized corpus measures. These findings will be crucial for development of the new discourse assessment material. Material will be based on picture stimuli in a computer-based application. Application will allow for the automatization of the recording procedure, transcription support and automatic calculation of discourse measures. As the material is grounded in research findings and validated, it will be ready for use as language assessment tool. Validity studies will provide reliable data on discourse development for different groups of speakers (monolingual, bilingual, atypical language development, different SES).It is expected that the project will a. provide a reliable insight into the cognitive and linguistic aspects that underlie the formation of a discourse, b. contribute to the body of research concentrated mainly on English data, c. develop or update language resources in open access needed for diverse linguistic research and d. provide knowledge relevant for language education and language assessment.]]></summary_en></project><project>
<id>6901</id><title_hr><![CDATA[Primjena naprednog peer-to-peer koncepta za trgovanje električnom energijom]]></title_hr><title_en><![CDATA[Implementation of Peer-to-Peer Advanced Concept for Electricity Trading]]></title_en><user_id>22498</user_id><user_firstLast_name>Ivan Rajšl</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2017-05</proposal_call><code>UIP-2017-05-4068</code><acronim><![CDATA[IMPACT]]></acronim><duration>01.07.2018 - 30.06.2023</duration><status>Završio</status><financ_value>160.431,96 eur</financ_value><scie_area_hr>Tehničke znanosti, Društvene znanosti, </scie_area_hr><scie_area_en>Technological sciences, Social sciences, </scie_area_en><scie_field_hr>Elektrotehnika, Ekonomija, Informacijske znanosti, </scie_field_hr><scie_field_en>Electrical engineering, Economy, Information sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id>22643, 20495, 22654, 22583, 22566, 22502, 903, 20517, 25411, 25407, </team_members_id><team_members_names><![CDATA[Zlatko Zmijarević, Zoran  Kordić, Perica Ilak, Marin Cerjan, Andrea Brajko, Goran Grdenić, Stjepan Sučić, Lin Herencic, Hrvoje Keko, Matej Cvitanović, ]]></team_members_names><keywords_hr><![CDATA[blockchain tehnologija, energetska demokracija, građanska energija, mikromreža, protrošači električne energije, peer-to-peer trgovanje]]></keywords_hr><keywords_en><![CDATA[blockchain technology, community energy, electricity prosumers, energy democracy, microgrid, peer-to-peer trading]]></keywords_en><summary_hr><![CDATA[Današnje moderne distribucijske mreže djelomično su transformirane iz pasivnih u aktivne posebno pod utjecajem značajne integracije OIE. Decentralizacija distribucijskih mreža jedan je od preduvjeta za energetsku demokraciju i poticaj malim korisnicima mreže da sudjeluju u trgovanju električnom energijom uvođenjem koncepta u kojem će pojedini korisnici električne energije, kao što su krajnji potrošači, proizvođači ili protrošači, trgovati električnom energijom unutar mikromrežnih zajednica. Takvo tržišno okruženje može se postići blockchain tehnologijom primijenjenom za peer-to-peer (P2P) transakcijske platforme.Budući da u takvom načinu trgovanja treće strane nisu nužne (preprodavači, operator tržišta), troškovi transakcija mogu se smanjiti, a procesi ubrzati. Blockchain Pametni ugovori automatski mogu pokrenuti transakciju između tržišnih sudionika (peer-ova) na temelju unaprijed definiranih individualnih i mrežnih parametra.Osim što se koristi za izvršavanje novčanih transakcija i reguliranje tokova snaga, predloženi P2P koncept također pruža osnovu za napredna mjerenja i naplate.Projekt ima za cilj uspostavu potpuno decentraliziranog energetskog sustava u kojem se ugovori o izravnoj trgovini električnom energijom između krajnjih korisnika mreže provode automatski.U prvom dijelu projekta provest će se detaljna analiza postojećeg tržišnog okruženja kako bi se ustanovila najbolja praksa primjene P2P koncepta u distribucijskim sustavima te razvio teorijski okvir za koncept P2P trgovanja električnom energijom.Teorijski koncept bit će osnova za drugi dio koji će se usredotočiti na razvoj novih algoritama i simulacijskih modela P2P koncepta trgovanja električnom energijom.Treći dio projekta će se usredotočiti na laboratorijsku implementaciju razvijenih simulacijskih modela i provedbu ispitivanja u SGLab laboratoriju FER-a.Rezultati naprednog koncepta P2P trgovine električnom energijom će se u završnoj fazi primijeniti u mikromreži na otoku Krku, Hrvatska.]]></summary_hr><summary_en><![CDATA[Today modern distribution grids have transformed partly from passive to active network especially due to significant recent RES integration. Decentralisation of distribution networks, can boost energy democracy and stimulate small electricity users to participate in trading electricity with introduction of concept where individual electricity users, such as end consumers, producers or prosumers will trade electricity within community microgrids. Such community energy market environment can be achieved through the blockchain technology for peer-to-peer (P2P) transaction platforms. Since third-party intermediaries (electricity retailers, market operator) are no longer needed the transaction costs could be lowered and processes accelerated. Blockchain’s smart contracts would automatically initiate transaction between peers based on predefined individual rules concerning desired network parameters. Besides being used to execute energy supply transactions and regulate power flows, proposed P2P concept also provides the basis for advanced metering, billing and clearing processes.The project aims at establishing a fully decentralised energy system in which energy supply contracts are made directly between end user of electricity that are carried out automatically. In the first part of the project detailed analysis of the existing market environment will be conducted in order to detect best practices of P2P in distribution systems and to develop theoretical framework for P2P electricity trading concept. Theoretical concept will be basis for the second part that will focus on developing novel algorithms, and simulation models of P2P electricity trading concept. The third part of the project will focus on laboratory implementation of developed simulation models and execution of testing in the SGLab laboratory on FER. Third part will result with advanced concept of P2P electricity trading that will be implemented into the real life site on microgrid in Krk Island, Croatia.]]></summary_en></project><project>
<id>6902</id><title_hr><![CDATA[Eksperimentalna i numerička istraživanja mehanizama u nesaturiranim geomaterijalima]]></title_hr><title_en><![CDATA[Experimental and numerical investigations of mechanisms in unsaturated geomaterials]]></title_en><user_id>22682</user_id><user_firstLast_name>Nataša Štambuk Cvitanović</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2017-05</proposal_call><code>UIP-2017-05-3429</code><acronim><![CDATA[UNSAT1]]></acronim><duration>01.03.2018 - 31.08.2023</duration><status>Završio</status><financ_value>190.473,32 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Građevinarstvo, </scie_field_hr><scie_field_en>Civil engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Splitu Fakultet građevinarstva, arhitekture i geodezije]]></institution_hr><institution_en><![CDATA[University of Split, Faculty of Civil Engineering, Architecture and Geodesy]]></institution_en><team_members_id>13219, 22635, 25729, </team_members_id><team_members_names><![CDATA[Mijo Nikolić, Goran Vlastelica, Ana Raič, ]]></team_members_names><keywords_hr><![CDATA[Geomaterijali, Meke stijene, Nesaturirani uvjeti, Usis, SWCC krivulja, Rastrošba,  Eksperimentalna istraživanja, Numeričko modeliranje]]></keywords_hr><keywords_en><![CDATA[Geomaterials, Soft rock, Unsaturated conditions, Suction, SWCC curve, Weathering, Experimental investigations, Numerical modelling]]></keywords_en><summary_hr><![CDATA[Rastrošba, kao degradacija stijene pod izravnim djelovanjem uvjeta okoliša i ljudske aktivnosti u razdoblju inženjerske skale vremena, je ključan proces koji nadzire druge geomorfološke, ekološke i društvene procese i zbivanja. Meke stijene poput lapora, vrlo rasprostranjene u području Mediterana, posebno su podložne rastrošbi. Pod djelovanjem čimbenika rastrošbe meke stijene se degradiraju sve do sitnozrnog materijala, uz što su vezani problemi održivosti okoliša te stabilnosti, nosivosti i trajnosti. Prema novijim znanstvenim spoznajama, značajan doprinos razvoju rastrošbe daje proces diferencijalnog usisa i njime izazvanog diferencijalnog bubrenja, koji se javlja u nesaturiranim uvjetima. Posljedica diferencijalnog bubrenja je razvoj vlačnih i posmičnih naprezanja koja dovode do rastrošbe. Stoga je cilj ovog projekta istražiti i modelirati mehanizme rastrošbe s aspekta usisa, te povezati dobivene spoznaje s brojnim istraživanjima čimbenika rastrošbe prikupljenim sustavnim radom na Fakultetu u prethodnom razdoblju. Posmična čvrstoća i deformabilnost u nesaturiranim uvjetima za zadano stanje sukcije, kao i karakteristične krivulje sadržaja vode u tlu ovisno o naprezanju (SDSWCC-Stress Dependent Soil Water Characteristic Curve), odredit će se eksperimentalno sofisticiranom istraživačkom opremom na još neispitanim materijalima meke stijene iz obalnog područja RH. Istovremeno će se provesti i sva popratna ispitivanja te povezati nova i postojeća baza podataka. Dobiveni rezultati ugradit će se u postojeći numerički model (Plaxis), a dodatno će se razviti i novi numerički model temeljen na diskretnom pristupu koji može obuhvatiti mehanizam loma u geomaterijalima u nezasićenim uvjetima protoka. Time bi se unaprijedilo područje poznavanja mehanizama rastrošbe u geomaterijalima općenito i omogućila održiva projektna rješenja. Novu vrijednost predstavlja i formirana istraživačka grupa s potrebnim resursima.]]></summary_hr><summary_en><![CDATA[Weathering as rock degradation under the direct influence of environmental conditions and human activity in the engineering period of time, is a key process that affects geomorphologic, ecologic and societal processes and events. Soft rocks, such as marl, are very common in the Mediterranean and particularly susceptible to weathering. Under the influence of many different processes, weathering degrades soft rocks to fine-grained material, coupled with environmental sustainability, stability, bearing capacity and durability issues. According to recent scientific findings, a significant contributor to the development of weathering is the process of differential suction and induced differential swelling, which occurs in unsaturated conditions. The consequences of differential swelling are development of tensile and shear stresses that cause weathering. Therefore, the aim of this project is to investigate and model the mechanisms of weathering from the aspect of suction, and to link the acquired new findings with the significant previous research carried out at the Faculty. The shear strength and deformability in unsaturated conditions for the given degree of suction, and the characteristic SDSWCC curves (Stress Dependent Soil Water Characteristic Curve) will be determined by sophisticated testing equipment on still unexamined soft rock material from the Croatian coastal area. At the same time all “accompanying” tests will be carried out and new and existing databases will be linked. The results obtained will be incorporated into the existing numerical model (Plaxis) and into additionally developed new numerical model based on a discrete approach, which will include the fracture mechanism in geomaterials in unsaturated flow conditions. This will significantly improve the knowledge of weathering mechanisms in geomaterials and enable sustainable project solutions. A newly formed research group with the necessary resources provides additional value of the proposed project.]]></summary_en></project><project>
<id>6910</id><title_hr><![CDATA[Misterij subtalamusa - anatomska podjela subtalamičke jezgre]]></title_hr><title_en><![CDATA[Mystery of subthalamus - anatomical division of the subthalamic nucleus]]></title_en><user_id>4125</user_id><user_firstLast_name>Goran Sedmak</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2017-05</proposal_call><code>UIP-2017-05-7578</code><acronim><![CDATA[3STAN]]></acronim><duration>01.06.2018 - 31.05.2023</duration><status>Prekinut</status><financ_value>264.782,00 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb School of Medicine]]></institution_en><team_members_id>17841, 4972, 22795, 25257, </team_members_id><team_members_names><![CDATA[Andrija Štajduhar, Fadi Almahariq, Ivana Jurjević, Ema Bokulić, ]]></team_members_names><keywords_hr><![CDATA[subtalamus, Parkinsonova bolest, DBS, razvojna neurobiologija, MRI, neuroanatomija]]></keywords_hr><keywords_en><![CDATA[subthalamus, Parkinson&#39;s disease, DBS, developmental neurobiology, MRI, neuroanatomy]]></keywords_en><summary_hr><![CDATA[Subtalamus je trenutno jedna od klinički najzanimljivijih struktura bazalnih ganglija. Neurokirurško stimuliranje subtalamičke jezgre pomoglo je mnogim bolesnicima s Parkinsonovom bolesti otpornom na levodopu, no dovelo je i do neželjenih nuspojava. Nuspojave su posljedica stimuliranja neželjenih dijelova subtalamičke jezgre. Iako je u kliničkoj praksi uvriježena podjela subtalamičke jezgre u tri segmenta, postoje mnoga istraživanja koja osporavaju tu tvrdnju. Prva studija o podjeli subtalamičke jezgre objavljena je 1925. godine. Od tada pa do danas objavljene su 43 studije na čovjeku i primatima koje se bave ovom temom koristeći različite metode. Pregledom ovih studija pokazalo se da taj zaključak nije posve opravdan. Naime, samo manji broj studija (4) zagovara tri segmenta subtalamičke jezgre, a broj segmenata seže od 0 do 4. Zbog izrazite kliničke značajnosti subtalamičke jezgre i nedosljednosti u opisu broja segmenata subtalamičke jezgre, u predloženom istraživanju analizirati ćemo podjelu subtalamičke jezgre pomoću klasičnih histoloških metoda (npr. Nissl, Gallyas), modernim histološkim metodama (imunohistokemija i in-situ hibridizacija), metodama slikovnog prikaza mozga (strukturni MR, DTI MR) i modernim metodama molekularne biologije. Za kvantitativnu histološku analizu koristiti ćemo stereološku metodu. Također u sklopu ovog projekta nastaviti ćemo razvoj i testiranje programskog rješenja za automatsko prepoznavanje i kvantifikaciju neurona na histološkim preparatima. U prvoj fazi projekta analizirati ćemo post-mortem uzorke subtalamičke jezgre pomoću histoloških metoda i strukturnih MR metoda. U drugoj fazi projekta korelirati ćemo dobivene post-mortem histološke i MR rezultate s MR nalazima subtalamičke jezgre u zdravih dobrovoljaca u svrhu izrade prostorne mape subtalamičke jezgre in-vivo. U trećoj fazi korelirati ćemo podatke iz prve dvije faza s MR nalazima pacijenata oboljelih od Parkinsonove bolesti prije i nakon duboke mozgovne stimulacije.]]></summary_hr><summary_en><![CDATA[The subthalamus is clinically one of the most important parts of the basal ganglia. Neurosurgical stimulation of the subthalamic nucleus has significantly helped patients with resistant levodopa treatment. However, it also led to many side effects. Side effects are result of unwanted stimulation of other parts of subthalamic nucleus. Although, in clinical use the subthalamic nucleus is divided in three parts, there are many studies which do not support this conclusion. The first study about its subdivision was conducted in 1925. Since then, 43 studies have addressed this issue using human or primate samples and various different methods. A survey of these studies showed that three partite division of subthalamus is not supported by evidence. Only small number of studies have divided subthalamus into 3 segments (4 studies), and number of segments spans from 0 to 4. Due to the significant importance of subthalamus and inconsistencies in its division, in the proposed research we will conduct analysis of anatomical subdivision of subthalamic nucleus using classical histological methods (e.g. Nissl, Gallyas), modern histological methods (e.g. immunohistochemistry, in-situ hybridization); MR imaging methods (e.g. structural MR, DTI MR) and modern molecular biology methods. The quantification of neurons will be done using stereological approach. Furthermore, within this project we will continue to develop and test the program solution for automatic neuron recognition and counting on histological slides. In the first phase of the project we will analyse post-mortem samples of subthalamic nucleus using histological and MR techniques. In the second phase we will correlate data from the post-mortem part with the MR finding of subthalamic nucleus in healthy volunteers in order to develop spatial map of subthalamic nucleus. In the third phase we will correlate the data from first two phases with the MR findings of Parkinsonian patients prior and after the deep brain stimulation.]]></summary_en></project><project>
<id>6912</id><title_hr><![CDATA[Bilinogojstvom do sekundarnih biljnih metabolita: primjena mineralnih hraniva i elicitora za povećanje koncentracije fenola u listu masline]]></title_hr><title_en><![CDATA[Phytochemical Farming: Mineral Nutrients and Elicitors Application to Enhance Olive Leaf Phenolics]]></title_en><user_id>12403</user_id><user_firstLast_name>Igor Pasković</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2017-05</proposal_call><code>UIP-2017-05-8464</code><acronim><![CDATA[PhytoFarmOL]]></acronim><duration>01.12.2017 - 31.05.2023</duration><status>Završio</status><financ_value>265.438,93 eur</financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Poljoprivreda, Biotehnologija, </scie_field_hr><scie_field_en>Agriculture, Biotechnology, </scie_field_en><institution_hr><![CDATA[Institut za poljoprivredu i turizam]]></institution_hr><institution_en><![CDATA[Institute of Agriculture and Tourism in Poreč]]></institution_en><team_members_id>19496, 22584, 22579, 25397, 25433, 27540, 19478, 855521, 26869, 865042, </team_members_id><team_members_names><![CDATA[Sunčana Simonić-Kocijan, Joško Kaliterna, Paula Žurga, Valerija Majetić Germek, Kristina Grozić, Šime Marcelić, maja Kinkela Devčić, Marin Cukrov, Nikolina Vidović, Marija Polić Pasković, ]]></team_members_names><keywords_hr><![CDATA[ishrana bilja, list masline, oleuropein, paunovo oko, oralno zdravlje]]></keywords_hr><keywords_en><![CDATA[plant nutrition, olive leaf, oleuropein, olive leaf spot, oral health]]></keywords_en><summary_hr><![CDATA[Fenolni spojevi oleuropein i hidroksitirosol smatraju se glavnim aktivnim spojevima lista masline za koje je dokazano antikancerogeno, protuupalno i antimikrobno djelovanje. Oleuropein i hidroksitirosol, ali i ostali fenoli, imaju specifičnu ulogu u zaštiti bilja i povećanju otpornosti na fitopatogene gljive što može biti od presudne važnosti za održivi uzgoj maslina općenito. Fenoli i polifenoli su sveprisutni spojevi u biljkama koji igraju važnu ulogu u obrambenom mehanizmu biljke domaćina u odnosu na filamentozne gljive. Važnost fenola, pored povećanja otpornosti biljke na patogene, očituje se i u proizvodnji funkcionalne hrane i nutraceutika te lijekova na prirodnoj bazi za liječenje oralnih bolesti. Potreba za pronalaskom novih terapijskih postupaka u liječenju patoloških stanja usne šupljine dovela je do povećanog interesa za upotrebu prirodnih supstrata.Dokazano je da poljoprivredna praksa može povećati sadržaj fenola u listu masline. Samo je nekoliko istraživanja do sada bilo usmjereno na proučavanje utjecaja mineralne ishrane na sastav fenola u listu masline. U ovom projektu planira se provesti cijeli niz eksperimenata kako bi se utvrdio utjecaj određenih mineralnih hraniva (N, Ca, Mg, Mn, Zn, Cu i B) i elicitora (fosfit i kalijev silikat) na sastav fenola u listu masline kod različitih sorata. Također ocijenit će se i utjecaj prethodnog odabranog mineralnog hraniva ili elicitora, koji se pokaže kao najučinkovitiji u povećanju razine fenola, na razvoj bolesti paunovo oko koje uzrokuje fitopatogena gljiva Venturia oleaginea (sin. Spilocaea oleaginea). Razvoj bolesti pratit će se na tretiranim maslinama u polju ili kontroliranim uvjetima u plasteniku. Učinak najboljeg tretmana bit će ispitan kroz kvalitetu maslinovog ulja na sorti Leccino uzgajanoj na različitim terroirima. U okviru ovog projekta također se planiraju provesti predklinička i klinička istraživanja utjecaja ekstrakta lista masline na kandidijazu usne šupljine.]]></summary_hr><summary_en><![CDATA[Oleuropein and hydroxytyrosol are considered the main active olive compounds and their health benefits thought their anti-carcinogenic, anti-inflammatory, and antimicrobial proprieties has been proven. Nevertheless, oleuropein and hydroxytyrosol as well as total phenols, have specific role plant protection and resistance against fungal pathogens which may be of crucial importance for olive sustainable growing. It has been noticed that phenolic and polyphenolic compounds, as pre-formed antibiotic compounds, are ubiquitous in plants and play an important role in host plant’s pre-existing chemical defences against filamentous fungi. The phenolics in olive leaves, beside upgraded resistance to fungal pathogens, may have potential in the production of functional food and nutraceuticals. They could be easily used as oral remedies in the treatment of stomatognatic pathological conditions, where the need of finding new therapeutic procedures has led to increased interest in the use of natural substrates. There are evidence that agricultural practices can increase phenolics in olive leaves. Only a few studies have been focused on studying the effects of olive mineral nutrition on the olive leaves phenolic profile. In this project, series of experiments are planned to be conducted in order to determine the effect of selected mineral elements (N, Ca, Mg, Mn, Zn, Cu, and B) and elicitors (phosphite and potassium silicate) on leaf phenolic profile of olive cultivars. The effect of previously selected mineral/elicitor treatment as the best phenolic enhancer, on the development of olive leaf spot (Venturia oleaginea - syn. Spilocaea oleaginea), will be tested under greenhouse and field conditions. The impact of best phenolic enhancer will be tested thought quality of olive oil on Leccino cultivar grown at different terroirs. The preclinical and clinical studies investigating the effect of olive leaf extract on oral cavity candidiasis will be conducted during this project as well.]]></summary_en></project><project>
<id>6913</id><title_hr><![CDATA[Optimiranje depozicije raspršenih in situ gelirajućih i praškastih terapijskih sustava u nosnoj šupljini]]></title_hr><title_en><![CDATA[Optimisation of nasal deposition pattern of sprayable in situ gelling and powder drug delivery systems]]></title_en><user_id>5296</user_id><user_firstLast_name>Anita Hafner</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2017-05</proposal_call><code>UIP-2017-05-4592</code><acronim><![CDATA[OptiNasalSpray]]></acronim><duration>01.01.2018 - 31.03.2023</duration><status>Završio</status><financ_value>237.839,27 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Farmacija, </scie_field_hr><scie_field_en>Pharmaceutical sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Farmaceutsko-biokemijski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Pharmacy and Biochemistry]]></institution_en><team_members_id>6672, 22585, 24926, 855425, 858334, </team_members_id><team_members_names><![CDATA[Ivan Pepić, Ivo Ugrina, Laura Nižić, Cvijeta Jakobušić Brala, Mirna Perkušić, ]]></team_members_names><keywords_hr><![CDATA[Profil depozicije, profil raspršivanja, in situ geliranje, sušenje raspršivanjem, nazalna primjena, flutikazon, donepezil]]></keywords_hr><keywords_en><![CDATA[Deposition pattern, spray pattern, in situ gelling, spray drying, nasal delivery, fluticasone, donepezil]]></keywords_en><summary_hr><![CDATA[Nazalna primjena privlači značajnu pažnju svjetske znanstvene zajednice kao atraktivni put primjene lijekova sa lokalnim i sistemskim učinkom, te naročito neuroloških lijekova koji se mogu dostaviti direktno iz nosne šupljine u mozak. Anatomija i fiziologija nosne šupljine prepoznati su kao kritični faktori u razvoju terapijskih sustava, a posebice mukocilijarni mehanizam čišćenja koji ograničava vrijeme kontakta lijeka s nosnom sluznicom. Međutim, ključni parametar o kojem ovisi terapijski ishod nazalno primijenjenog lijeka je njegova depozicija unutar nosne šupljine.Cilj predloženog projekta je razviti terapijski sustav za nazalnu primjenu u obliku spreja, pažljivo dizajniranog profila depozicije i povoljnih biofarmaceutskih svojstava, a ovisno o ciljnom učinku lijeka. U istraživanju će se koristiti dva modelna lijeka, flutikazon – lijek s lokalnim učinkom koji treba doseći zonu polipa iza nosnih valvula, te donepezil- antidementik kojeg treba dostaviti u olfaktorno područje nosne šupljine kako bi se omogućila njegova direktna dostava u mozak. U izradi terapijskih sustava ispitat će se i usporediti primjenjivost dviju tehnologija s jednostavnim uvećanjem procesa: tehnologija in situ gelirajućih sustava i prašaka pripravljenih sušenjem raspršivanjem. Navedene tehnološke platforme omogućuju razvoj terapijskih sustava koji mogu produljiti vrijeme zadržavanja na mjestu depozicije te kontrolirati profil oslobađanja i apsorpcije lijeka.Nazalna depozicija ispitivat će se primjenom modela nosne šupljine uz simuliranje protoka zraka pri disanju. Fino ugađanje profila depozicije omogućit će se variranjem procesnih i formulacijskih parametara, uz primjenu različitih raspršivača i parametara primjene.Primjena statističkog dizajna eksperimenata omogućit će vrednovanje i razumijevanje utjecaja promatranih parametara na svojstva/profil depozicije in situ gelirajućih i praškastih sustava, te razvoj nazalnih pripravaka s ugrađenom kvalitetom uz uštedu uloženih sredstava i vremena.]]></summary_hr><summary_en><![CDATA[Nasal delivery receives much attention of the worldwide scientific community as an attractive route for drugs with local or systemic effect, and especially neurological drugs that can be delivered directly from the nasal cavity to the brain. The anatomy and physiology of the nasal cavity are recognized as the most critical factors in drug delivery system design, especially mucociliary clearance that limits the contact time between the drug and mucosa. However, the crucial parameter for the treatment outcome of nasally applied drug is its deposition within the nasal cavity. The purpose of the proposed project is to develop sprayable nasal delivery systems with carefully designed deposition pattern and favorable biopharmaceutical properties, in relation to targeted drug effect. Two model drugs will be used: fluticasone - a locally acting drug that needs to reach the polyp zone beyond the nasal valve, and donepezil - antidementic drug that needs to be deposited in the olfactory region within the nasal cavity to be directly transported to the brain.For the formulation development, applicability of two technologies that can be easily scaled up will be assessed and compared, namely, technology of in situ gelling systems and spray-dried powders. These technological platforms can be used to develop formulations able to prolong residence time at the deposition site and control drug release and absorption profiles.Nasal deposition will be studied using nasal cavity model simulating breath airflow. The deposition pattern will be fine-tuned by varying process and formulation parameters, in conjunction with different nasal devices and administration parameters.The usage of statistical Design of Experiments will enable the evaluation and elucidation of the influence of parameters employed on the characteristics/deposition pattern of developed drug delivery systems, potentiating the development of nasal formulations with built-in quality attributes in cost and time-saving manner.]]></summary_en></project><project>
<id>6917</id><title_hr><![CDATA[Razvoj, validacija i primjena analitičkih metoda za određivanje PBDE-a]]></title_hr><title_en><![CDATA[Development, validation and application of analytical methods for PBDE determination]]></title_en><user_id>1376</user_id><user_firstLast_name>Darija Klinčić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2017-05</proposal_call><code>UIP-2017-05-6713</code><acronim><![CDATA[DeValApp]]></acronim><duration>01.10.2018 - 30.09.2023</duration><status>Završio</status><financ_value>189.063,64 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, </scie_field_hr><scie_field_en>Chemistry, </scie_field_en><institution_hr><![CDATA[Institut za medicinska istraživanja i medicinu rada]]></institution_hr><institution_en><![CDATA[Institute for Medical Research and Occupational Health]]></institution_en><team_members_id>1490, 21444, 25491, </team_members_id><team_members_names><![CDATA[Marija Dvoršćak, Andreja Jurič, Karla Jagić, ]]></team_members_names><keywords_hr><![CDATA[polibromirani difenil eteri (PBDE), razvoj metode, mirkovalna ekstrakcija, GC-ECD, GC-MS, GC-MS/MS, kućna prašina, ljudsko mlijeko]]></keywords_hr><keywords_en><![CDATA[polybrominated diphenyl ethers (PBDEs), method development, microwave-assisted extraction (MAE), GC-ECD, GC-MS, GC-MS/MS, house dust, human milk]]></keywords_en><summary_hr><![CDATA[Svrha predloženog projekta je razvoj i validacija analitičkih metoda za određivanje specifičnih kongenera polibromiranih difenil etera (PBDE) u složenim uzorcima kućne prašine i ljudskog mlijeka. PBDE su široko rasprostranjeni u okolišu, akumuliraju se u hranidbenom lancu te dospijevaju u ljude na čije zdravlje mogu imati niz negativnih utjecaja. Kućna prašina prepoznata je kao važan izvor izloženosti ovim spojevima zbog njihove intenzivne uporabe kao usporivača gorenja u predmetima široko korištenim u svakom kućanstvu (namještaj, tekstil, električni i elektronski uređaji) dok je ljudsko mlijeko pouzdan bioindikator izloženosti ljudi ovim spojevima. Razvoj analitičkih metoda uključivat će ispitivanje i usporedbu različitih tehnika ekstrakcije analita iz uzorka pri čemu uz ekstrakciju na čvrstoj fazi i ultrazvučnu ekstrakciju posebno treba naglasiti primjenu dosad nekorištene metode, mikrovalne ekstrakcije. Ispitat će se načini i uvjeti pročišćavanja ekstrakta od interferirajućih spojeva i sastojaka matrice prije završne instrumentne analize. Odredit će se osjetljivost i selektivnost plinskokromatografskog određivanja PBDE-a uz detektore zahvata elektrona, spektrometar masa i spregnuti sustav tandemne spektrometrije masa. Validirane metode bit će provjerene analizom potvrđenih referencijskih uzoraka. Tijekom  projekta skupljat će se uzorci ljudskog mlijeka, a u domovima ispitanica paralelno će se uzorkovati i kućna prašina. Optimirane i validirane analitičke metode primijenit će se za analizu PBDE-a u skupljenim uzorcima. Dobiveni rezultati o razinama i raspodjeli PBDE-a bit će prvi takvi u Hrvatskoj i služit će za procjenu  važnosti unosa PBDE-a u organizam putem udisanja kućne prašine te izloženosti opće populacije PBDE-ima. Iz svega navedenog zaključit će se postoji li potencijalni rizik za zdravlje ljudi s posebnim naglaskom na osjetljive skupine dojilja, dojenčadi i male djece.]]></summary_hr><summary_en><![CDATA[The purpose of the proposed project is to develop and validate analytical methods for determining specific polybrominated diphenyl ether (PBDE) congeners in complex samples of house dust and human milk. PBDEs are widespread in the environment, they accumulate in the food chain and enter human organism where they can exert a number of negative impacts. House dust is recognized as an important source of exposure to PBDEs because of their intensive use as flame retardants in objects widely used in households (furniture, textiles, electrical and electronic devices). On the other hand, human milk is a reliable bioindicator of people&#39;s exposure to these compounds. The development of analytical methods will involve the examination and comparison of various types of extraction techniques, whereby along with the solid phase extraction and ultrasonic extraction, particular emphasis will be put on the application of an unused technique, microwave extraction. Techniques and conditions for the cleanup of the extract from the interfering compounds and matrix components before the final instrument analysis will be investigated. The sensitivity and selectivity of gas-chromatographic determination of PBDEs by electron capture detectors, mass spectrometer and coupled tandem mass spectrometry will be determined. Validated methods will be confirmed by analysis of certified reference samples. During the project, house dust will be sampled in the homes of milk donors. The optimized and validated analytical methods will be used for PBDE analysis in collected samples. Results on PBDE levels and distribution will be the first of a kind in Croatia and will be used to assess the importance of PBDE intake in the body by inhaling house dust and exposure of general population to PBDEs. From all of the above mentioned, it will be concluded whether there is a potential risk to human health with a special emphasis on sensitive population groups of nursing mothers, infants and young children.]]></summary_en></project><project>
<id>6925</id><title_hr><![CDATA[Razvoj naprednih analitičkih metoda za lijekove i biološki aktivne tvari u liječenju upalnih bolesti crijeva]]></title_hr><title_en><![CDATA[Development of sophisticated analytical methods for drugs and biologically active compounds in inflammatory bowel disease treatment]]></title_en><user_id>1301</user_id><user_firstLast_name>Ana Mornar Turk</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2017-05</proposal_call><code>UIP-2017-05-3949</code><acronim><![CDATA[IBDAnalytics]]></acronim><duration>01.01.2018 - 31.03.2023</duration><status>Završio</status><financ_value>171.610,33 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Farmacija, Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Pharmaceutical sciences, Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Farmaceutsko-biokemijski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Pharmacy and Biochemistry]]></institution_en><team_members_id>13100, 25223, 29172, 25304, 865187, </team_members_id><team_members_names><![CDATA[Miranda Sertić, Mario-Livio Jeličić, Maja Friščić, Edvin Brusač, Jelena Kovačić, ]]></team_members_names><keywords_hr><![CDATA[upalne bolesti crijeva, kromatografija, masena spektrometrija, tehnike pripreme uzoraka, kontrola kvalitete lijekova, dodaci prehrani, biološki lijeko]]></keywords_hr><keywords_en><![CDATA[inflammatory bowel disease, chromatography, mass spectrometry, sample preparation, ADME, quality control, dietary supplements, biopharmaceuticals]]></keywords_en><summary_hr><![CDATA[Upalne bolesti crijeva (UBC) spadaju u skupinu upalnih bolesti kod kojih upalni proces zahvaća područje tankog i debelog crijeva. Odabir farmakoterapije ovisno o proširenosti  i smještenosti bolesti,  neželjenim popratnim pojavama i cijeni. Budući da smanjuju potrebu za koritikosteroidima, imunomodulatori su najčešće propisivani lijekovi u liječenju UBC. Liječenje s monoklonskim protutijelima omogućava liječenje visoko specifičnim i neposrednim mehanizmom djelovanja, ali visoka cijena utječe na učestalost primjene ove skupine lijekova.Budući da upalni procesi u crijevima narušavaju resorpciju vitamina i minerala, pacijentima se preporuča njihova suplementacija tijekom farmakoterapije. Štoviše, nedostatak folne kiseline povećava rizik razvoja tumora kod pacijenata oboljelih od UBC.Velik broj pacijenata smatra dodatke prehrani koje sadrže biljne ekstrakte sigurnim i prirodnim načinom liječenja. Stoga, velik broj pacijenata oboljelih od UBC koriste dodatke prehrani koji sadrže indijski tamjanovac, justiciju i kurkumu.Glavni cilj predloženog istraživanja je razviti nove instrumentalne analitičke metode za kontrolu kvalitete lijekova i dodataka prehrani koji se koriste u liječenju UBC.Kako bi se poboljšala suradljivost pacijenata predložit će se nove fiksne kombinacije imunosupresiva i folne kiseline. Razvit će se metode za ispitivanje farmakokinetike, kontrole kvalitete i terapeutskog praćenja koncentracije lijekova. Razvit će se i analitičke metode za određivanje aktivnih i toksičnih tvari u biljnim dodacima prehrani te će se metode primijeniti za procjenu kvalitete dodataka prehrani na hrvatskom tržištu. Konačno, razvit će se 2D-SE-RP-DAD tehnika za određivanje monoklonskih protutijela i njihovih onečišćenja u biološkim i biosličnim lijekovima.]]></summary_hr><summary_en><![CDATA[Inflammatory bowel disease (IBD) is a group of inflammatory conditions of the colon and small intestine. In IBD, treatment decision is dependent on the stage of the disease, laboratory findings and endoscopic examination. Choice of pharmacotherapy depends largely on the severity of disease, location, side effects and adverse events, as well as cost. Immunosuppressants are the most prescribed drug class in IBD treatment as steroid-sparing therapy. The treatment of IBD with monoclonal antibodies presents high specificity and directed mechanism of action, but the high cost still represents a barrier to be overcome. As the inflammatory process along the digestive tract disrupts resorption of vitamins and minerals, their additional supplementation is recommended with pharmacotherapy therapy. Moreover, low folate intake has been associated with tumor growth in IBD. The majority of the patients consider herbal dietary supplements are safe and natural way of healing. Many patients with IBD take supplements such as Indian frankincense, Justicia and Turmeric. The main objective of the proposed research is to develop new instrumental analytical methods that could be applied in quality control of medicinal products and dietary supplements used in treatment of IBD. A new fix-dose combination of two drugs an immunosuppressant and folic acid to improve patient&#39;s adherence to their prescribed treatment will be proposed. Methods for investigation of pharmacokinetic behaviour, quality control and therapeutic drug monitoring will be developed. Analytical methods for determination of active and toxic compounds of herbal dietary supplements will be developed. The proposed methods will be applied for evaluation of quality assurance for dietary supplements in Croatian marketplace. Finally, an advanced 2D-SE-RP-HPLC/DAD technique will be proposed and applied for determination of monoclonal antibodies and their impurities in biologic drugs and biosimilars.]]></summary_en></project><project>
<id>6926</id><title_hr><![CDATA[Transormacija robota u edukacijsko sredstvo]]></title_hr><title_en><![CDATA[Transforming robots into educational tool ]]></title_en><user_id>6592</user_id><user_firstLast_name>Ana Sović Kržić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2017-05</proposal_call><code>UIP-2017-05-5917</code><acronim><![CDATA[TRES]]></acronim><duration>15.03.2018 - 14.03.2023</duration><status>Završio</status><financ_value>171.743,31 eur</financ_value><scie_area_hr>Tehničke znanosti, Društvene znanosti, </scie_area_hr><scie_area_en>Technological sciences, Social sciences, </scie_area_en><scie_field_hr>Temeljne tehničke znanosti, Elektrotehnika, Računarstvo, Obrazovne znanosti, </scie_field_hr><scie_field_en>Basic engineering sciences, Electrical engineering, Computer sciences, Educational sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id>22784, 25376, 25956, 28856, 857307, 865176, </team_members_id><team_members_names><![CDATA[Kristina Cergol Kovačević, Liljana Pushkar, Petra Karabin, Ivana Storjak, Ivan Kunović, Valentina Gučec Gučec, ]]></team_members_names><keywords_hr><![CDATA[edukacijski robot, analitika učenja, obrada video signala, otkrivanje znanja u skupovima podataka, edukacijsko sredstvo, nastavni materijali]]></keywords_hr><keywords_en><![CDATA[educational robot, learning analytics, video processing, data mining, educational tool, learning materials]]></keywords_en><summary_hr><![CDATA[Današnji trend je korištenje velikog broja elektroničkih uređaja u razredu: pametne ploče, prezentacije, Internet, edukacijski roboti. Iz mnoštva uređaja i informacija, teško je odrediti pomažu li oni uopće u poučavanju. Mnoge aktivnosti se upravo svode na njihovo korištenje, a ne na iskorištavanje njihovih prednosti s ciljem poučavanja. Predloženi projekt će razviti metodologiju evaluacije korištenja edukacijskih robota u poučavanju osnovnoškolskih predmeta. Pri tome će se uzeti u obzir postignuta razina znanja, ali i zadovoljstvo učenika za vrijeme i nakon održanog sata. Dodatno, roboti će se koristiti za identifikaciju individualne strategije učenja svakog učenika. Na temelju razvijene metodologije i eksperimentalnih rezultata, napravit će se usporedna analiza edukacijskih robota koji postoje na tržištu. Kako bi se postigli ciljevi projekta koristit će se analitički podaci koje je moguće prikupiti iz samih robota i njihovih programskih okruženja za vrijeme njihove upotrebe. Razvit će se algoritmi obrade prikupljenih informacija, njihova analiza, evaluacija i vizualizacija. Predložit će se prototip sustava koji uključuje unaprijeđene edukacijske robote, individualnu strategiju učenja učenika i nastavne materijale, a sa ciljem postizanja maksimuma znanja i uz maksimalno ugodan proces učenja. Istraživači okupljeni u istraživačku grupu su iskusni u dizajniranju, programiranju i korištenju edukacijskih robota, u razvoju metodologije istraživanja, u radi s učenicima osnovnih škola, te u otkrivanju znanja u skupovima podataka i u razvoju metoda znanosti o podacima.]]></summary_hr><summary_en><![CDATA[Today&#39;s trend is to use a number of electronic devices during the class: smart boards, presentations, the Internet, educational robots. From a plenty of devices and information, it is difficult to determine do they help or not in teaching pupils. Many activities are just about how to use the devices, and not to exploit their strengths in the teaching process. Proposed project will develop methodology for evaluation of the usage of educational robots in teaching primary school subjects. The methodology will consider the level of knowledge as well as learners’ satisfaction during and after the lessons. Additionally, the robots will be used for identification of individual learning strategies. Based on the developed methodology and experimental results, comparison of the state-of-the-art educational robots will be made. To achieve the project goals, analytic data will be collected from the logs of the educational robots and their programming environments. Algorithms for processing of the collected data, their analysis, evaluation and visualization will be developed. Finally, a prototype of a system, that includes the improved educational robots, the individual learning strategies and teaching materials will be proposed. The aim of the prototype is to achieve the maximum of the knowledge through a satisfying learning process. Researchers gathered in the research group have experience in designing, programming and using educational robots, in developing research methodologies, in field work with pupils, and in data mining and data science methods.]]></summary_en></project><project>
<id>6927</id><title_hr><![CDATA[Filogeografija i evolucija triju ekološki divergentnih grupa amfi-jadranskih biljaka]]></title_hr><title_en><![CDATA[Phylogeography and evolution of three ecologically divergent amphi-Adriatic plant groups]]></title_en><user_id>13550</user_id><user_firstLast_name>Ivana Rešetnik</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2017-05</proposal_call><code>UIP-2017-05-2882</code><acronim><![CDATA[AmphiAdriPlant]]></acronim><duration>01.03.2018 - 28.02.2024</duration><status>Završio</status><financ_value>231.465,26 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Biologija, </scie_field_hr><scie_field_en>Biology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>22700, 28771, 25313, 17842, 11179, </team_members_id><team_members_names><![CDATA[Ivica Ljubičić, Marko  Doboš, Ana Terlević, Maja Mucko, Martina Temunovic, ]]></team_members_names><keywords_hr><![CDATA[filogeografija, glacijalni refugiji, amfi-jadranske biljke, modeliranje ekoloških niša, RADseq]]></keywords_hr><keywords_en><![CDATA[phylogeography, glacial refugia, amphi-Adriatic plants, habitat suitability models, RADseq]]></keywords_en><summary_hr><![CDATA[Jugoistočna Europa predstavlja jedan od glavnih centara europske bioraznolikosti, prvenstveno zahvaljujući činjenici da su Apeninski i Balkanski poluotok djelovali kao glavni glacijalni refugiji biljnih i životinjskih vrsta tijekom glacijalno-interglacijskih ciklusa u Kvartaru. U sklopu ovog projekta predlažemo komparativnu filogeografsku studiju koja kombinira tradicionalne (morfolgija i plastidne DNK sekvence) i nove pristupe, kao što su sekvenciranje slijedeće generacije (RADseq) i modeli povoljnosti staništa kako bi se istražiti evolucijski putevi i diversifikacija triju ekološki divergentnih biljnih skupina rasprostranjenih na Apeninskom i Balkanskom poluotoku. Prvo ćemo rekonstruirati pojedinačne filogeografije vrsta Aurinia leucadea, A. sinuata, Festuca bosniaca i Dianthus sylvestris grupe na Balkanu i Apeninima kako bismo otkrili detaljne obrasce genetske raznolikosti divergentnih linija. Drugo, identificirat ćemo morfološke varijacije u istraživanim skupinama i ispitati da li morfološka divergencija odgovara genetskoj raznolikosti i/ili trenutnoj taksonomiji. Treće, procijenit ćemo njihove ekološke niše kako bismo otkrili potencijalnu sadašnju i prošlu rasprostranjenost te ćemo istražiti odnose između genetskih i ekoloških razlika. Četvrto, ispitat ćemo prostornu i vremensku podudarnost između rekonstruiranih filogeografija i usporediti dobivene lokacije glacijalnih refugija kao i putanje postglacijalnih širenja. Važnost predloženog projekta leži u tri točke: 1) dobiveni RADseq podaci visoke razlučivosti omogućit će sveobuhvatno ispitivanje prirodnih varijacija u širokom prirodnom okruženju, 2) dobiveni rezultati predstavljat će izravan doprinos očuvanju i upravljanju prirodom, i 3) sinteza komparativne filogeografije i modeliranja povoljnosti staništa pridonijet će rješavanju intrigantnih pitanja koja su daleko izvan ispitivane skupine: kako je bioraznolikost na Balkanu i Apeninima nastala te koji su procesi bili uključeni u njezino stvaranje. ]]></summary_hr><summary_en><![CDATA[South-eastern Europe is one of the major European biodiversity hotspots largely due to the fact that Apennine and Balkan Peninsulas have acted as major glacial refugia of temperate species during the Quaternary glacial–interglacial cycles. Here we propose a comparative phylogeographic study that combines traditional (morphology and plastid DNA sequences) and brand new approaches taking advantage of next-generation sequencing (RADseq) and habitat suitability modelling in order to explore the evolutionary trajectories and diversification of three ecologically divergent plant groups distributed on Apennine and Balkan Peninsulas. First, we will reconstruct the individual phylogeographic histories of Aurinia leucadea, A. sinuata, Dianthus sylvestris group and Festuca bosniaca on Balkan and Apennine Peninsulas to reveal range-wide patterns of genetic diversity. Second, we will identify morphological variation in the study groups and examine if morphological divergence corresponds to genetic diversity and/or current taxonomy. Third, we will evaluate their ecological niches to obtain potential present and past distributions and to examine the relationship between genetic and environmental divergence. Fourth, we will examine spatial and temporal congruence among the reconstructed phylogeographies and compare inferred locations of glacial refugia and postglacial expansion routes. The power of the proposed study lies in three points: 1) the implementation of high-resolution RADseq data will provide comprehensive examination of natural variation within range-wide native environment, 2) the obtained results will present direct contribution to nature conservation and management, and 3) the synthesis of comparative phylogeography and habitat suitability modelling will yield a much broader basis to address questions of interest going far beyond the group investigated: how the biodiversity on the Balkans and Apennines arose and which processes were involved in its formation. ]]></summary_en></project><project>
<id>6935</id><title_hr><![CDATA[Stohastička stabilnost i teorija potencijala Markovljevih procesa]]></title_hr><title_en><![CDATA[Stochastic stability and potential theory of Markov processes]]></title_en><user_id>987</user_id><user_firstLast_name>Nikola Sandrić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2017-05</proposal_call><code>UIP-2017-05-8958</code><acronim><![CDATA[SSPTMP]]></acronim><duration>01.05.2018 - 30.04.2023</duration><status>Završio</status><financ_value>44.827,13 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Matematika, </scie_field_hr><scie_field_en>Mathematics, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>635, 22576, 22575, </team_members_id><team_members_names><![CDATA[Vanja Wagner, Petra Lazić, Ivana Valentić, ]]></team_members_names><keywords_hr><![CDATA[cenzurirani Levyev proces, Harnackova nejednakost, homogenizacija, Markovljev proces, stohastička stabilnost, slučajna okolina, teorija potencijala]]></keywords_hr><keywords_en><![CDATA[censored Levy process, Harnack inequality, homogenization, Markov process, stochastic stability, random environment, potential theory ]]></keywords_en><summary_hr><![CDATA[Veliki broj fenomena koji se javljuju u prirodi i inženjerstvu uključuju određeni stupanj nedeterminističnosti u svojem ponašanju. Prikladan matematički alat u modeliranju takvih fenomena je teorija vjerojatnosti. Osnovna zadaća te teorije je razvoj različitih matematičkih koncepata koji omogućavaju predviđanje budućeg ponašanja fenomena kojeg proučavamo.Fokus istraživanja ovog projekta je klasa tzv. Markovljevih procesa. To su stohastički procesi karakterizirani odsustvom memorije. Zbog tog svojstva, primjenetih procesa su brojne, kako u teoriji tako i u praksi. Osim njihove primjene u drugim područjima znanosti i inženjerstva, oni su također usko povezani s nizom drugih grana matematike.U ovom projektu usredotočit ćemo se na dva osnovna problema u teoriji i primjenamaMarkovljevih procesa: (i) stohastičkoj stabilnosti te (ii) teoriji potencijala Markovljevih procesa. Obje predložene teme pripadaju klasičnom smjeru u analizi Markovljevih procesa i motivirane su trenutnim smjerom istraživanja u teoriji i primjenama stohastičkih procesa. Stohastički stabilni Markovljevi procesi prirodno se nameću kao matematički modeli niza fenomena koji se javljuju u prirodi i inženjerstvu, kao što su problemi vezani uz rast populacija i homogenizaciju heterogenih struktura. Teorija potencijala nastala je u sklopu matematičke fizike kao osnovni alat za proučavanje elektrostatičkih i gravitacijskih problema. Cilj ovog projekta je poboljšati i unaprijediti postojeće metode, modele i pristupe te razviti nove s ciljem boljeg razumijevanja prirode Markovljevih procesa kroz njihovu stohastičku stabilnost i potencijalna svojstva. U tu svrhu bit će kombinirani pristupi i alati iz različitih matematičkih disciplina, poput teorije vjerojatnosti i stohastičkih procesa, matematičke analize i teorije diferencijalnih jednadžbi.]]></summary_hr><summary_en><![CDATA[Many phenomena arising in nature and engineering are characterized by a certaindegree of randomness in their behaviour. A suitable mathematical tool in modelling such phenomena is probability theory. The main task of this theory is to develop various mathematical concepts which allow us to predict the future behaviour of the phenomenon we are studying.The focus of research of this project is the class of so-called Markov processes. These are stochastic processes characterized by the absence of memory. Due to this feature, applications of these processes are numerous, both in theory and applications. Besides their application in other areas of science and engineering, they are also closely related to a number of other branches of mathematics. In this project, we will focus on two fundamental problems in the theory and applications of Markov processes: (i) stochastic stability and (ii) potential theory of Markov processes. Both proposed topics belong to the classical direction in the analysis of Markov processes and are motivated by the current direction of research in the theory and applications of stochastic processes. Stochastically stable Markov processes naturally arise as mathematical models in a number of phenomena arising in nature and engineering, such as problems related to population dynamics and homogenization of heterogeneous structures. Potential theory originates from mathematical physics as a basic tool in studying electrostatic and gravitational problems. The goal of this project is to improve and advance existing methods, models and approaches and to develop new ones with aim of better understanding the nature of Markov processes through their stochastic stability and potential theoretical properties. For this purpose, approaches and tools from various mathematical disciplines, such as probability theory, theory of stochasticprocesses, mathematical analysis and theory of differential equations will becombined.]]></summary_en></project><project>
<id>6936</id><title_hr><![CDATA[Promjene sastava patogena i imunološkog odgovora tijekom širenja areala uspješnih invazivnih vrsta slatkovodnih rakova]]></title_hr><title_en><![CDATA[Changes in the pathogen composition and immune response during range expansion of successful crayfish invaders]]></title_en><user_id>19913</user_id><user_firstLast_name>Sandra Hudina</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2017-05</proposal_call><code>UIP-2017-05-1720</code><acronim><![CDATA[STRIVE]]></acronim><duration>01.04.2018 - 30.09.2023</duration><status>Završio</status><financ_value>194.640,65 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Biologija, </scie_field_hr><scie_field_en>Biology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>19735, 22737, 25151, </team_members_id><team_members_names><![CDATA[Maja Šrut, Silvija Černi, Paula Dragičević, ]]></team_members_names><keywords_hr><![CDATA[invazivne vrste, slatkovodni ekosustavi, širenje areala, imunološki odgovor, patogeni]]></keywords_hr><keywords_en><![CDATA[invasive species, freshwaters, range expansion, immune response, pathogens]]></keywords_en><summary_hr><![CDATA[Invazivne strane vrste (ISV) imaju negativan utjecaj na funkciju i usluge ekosustava diljem svijeta, te njihova predikcija i upravljanje predstavljaju globalni izazov. Brzo širenje je bitna odrednica invazivnog uspjeha dok patogeni mogu značajno mijenjati invazivni uspjeh jer utječu na ekologiju svojih domaćina. Tijekom širenja areala ulaganje u imunološki odgovor na frontama invazije vjerojatno će biti izmijenjeno zbog promijenjenog pritiska patogena i ekoloških procesa koji se javljaju tijekom širenja. Smanjena brojnost/raznolikost patogena i potencijalno manja stopa njihovog prijenosa pri niskim gustoćama domaćina mogla bi smanjiti potrebu za jakim imunološkim odgovorom. S druge strane, jedinke koje dolaze u novi okoliš potencijalno su izložene većem opsegu patogena što bi zahtijevalo pojačani imunološki odgovor. S obzirom da i smanjeni i pojačani imunološki odgovor može koristiti jedinkama na frontama invazije, nije očigledno koja od ovih tendencija će prevladati prilikom širenja areala. Predloženi projekt će ispitati ovu temu koristeći grupu uspješnih slatkovodnih ISV – deseteronožne rakove. Prvo ćemo usporediti raznolikost i zastupljenost mikrobnih zajednica i intenzitet imunološkog odgovora invazivne vrste signalnog raka (Pacifastacus leniusculus) iz središta i s fronti širenja u rijeci Korani. Zatim ćemo provesti opsežno laboratorijsko istraživanje koristeći partenogenetsku vrstu mramornog raka (Procambarus fallax f. virginalis) kako bismo identificirali učinke gustoće, imunološkog odgovora i prisutnosti patogena na rast i reprodukciju jedinki. Završno, temeljem prikupljenih podataka kvantificirati ćemo kompromise između energetskih ulaganja u imunološki odgovor naspram ulaganja u karakteristike životnog ciklusa bitnih za invazivni uspjeh koristeći dinamičko modeliranje energetskih budžeta. Ovakav sveobuhvatni okvir istraživanja omogućiti će procjenu uloge i posljedica promjena imunološkog odgovora u invazivnom uspjehu.]]></summary_hr><summary_en><![CDATA[Invasive species impair ecosystem function and services worldwide and prediction and management of successful invaders represents a global challenge. Rapid dispersal is an important determinant of invasion success. Pathogens may greatly impact invasion success since they influence host ecology/evolution. Due to altered pathogen pressures and ecological processes arising from dispersal, immune investment will likely be altered during range expansion. Lower pathogen prevalence and potentially lower transmission rates at low densities of available hosts at invasion fronts might reduce the need for strong immune response. On the other hand, in a novel environment individuals may experience a broader range of pathogens which would require increased immune investment. Since individuals at the invasion front could benefit from both elevated and decreased immune response, it is not immediately obvious which of these tendencies will prevail during range expansion. We will test these issues using a successful group of freshwater invaders – non-indigenous crayfish. Firstly, we will compare diversity and abundance of crayfish associated microbiota and the intensity of immune response in individuals of the invasive signal crayfish (Pacifastacus leniusculus) from the invasion core and invasion fronts in the Korana River, Croatia. Secondly, we will perform an extensive laboratory study using parthenogenetic marbled crayfish (Procambarus fallax f. virginalis) to identify the effects of population density, pathogen presence, and immune response on individual growth and reproduction. Based on this input, we aim to quantify potential energy allocation trade-offs between immune function and life-history traits promoting invasion success using dynamic energy budget modelling. This comprehensive framework will allow us to assess population-level consequences of immune response alterations and their role in invasion success of a species.]]></summary_en></project><project>
<id>6938</id><title_hr><![CDATA[Razvoj armiranobetonskih elemenata i sustava s otpadnim prahom automobilskih guma ]]></title_hr><title_en><![CDATA[Development of Reinforced Concrete Elements and Systems with Waste Tire Powder]]></title_en><user_id>4343</user_id><user_firstLast_name>Ivana Miličević</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2017-05</proposal_call><code>UIP-2017-05-7113</code><acronim><![CDATA[ReCoTiP]]></acronim><duration>01.01.2018 - 31.12.2022</duration><status>Završio</status><financ_value>240.516,96 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Građevinarstvo, Temeljne tehničke znanosti, </scie_field_hr><scie_field_en>Civil engineering, Basic engineering sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište Josipa Jurja Strossmayera u Osijeku, Građevinski i arhitektonski fakultet Osijek]]></institution_hr><institution_en><![CDATA[Josip Juraj Strossmayer University of Osijek, Faculty of Civil Engineering and Architecture Osijek]]></institution_en><team_members_id>3043, 3049, 3081, 4092, 22571, 13426, 22521, 24514, 24511, </team_members_id><team_members_names><![CDATA[Tanja Kalman Šipoš, Marin Grubišić, Ivana Šandrk Nukić, Marijana Hadzima-Nyarko, Hugo Rodrigues, Naida Ademovic, Tihomir Dokšanović, Robert Bušić, Kristina  Strukar, ]]></team_members_names><keywords_hr><![CDATA[prašina reciklirane gume, samozbijajući beton, konstrukcijski elementi, potresna otpornost, a-b okvir]]></keywords_hr><keywords_en><![CDATA[tire powder,  self-compacting concrete, structural elements, seismic resistance, r-c frame]]></keywords_en><summary_hr><![CDATA[Glavni cilj ReCoTiP projekta je razvoj novog materijala, samozbijajućeg betona s otpadnim prahom automobilskih guma, primijenjenog u nosivim armirano-betonskim konstrukcijama poboljšane potresne otpornosti. Definirani cilj postići će se osnivanjem nove međunarodne istraživačke grupe mladih znanstvenika u svrhu ubrzanog procesa razvoja neovisnih istraživačkih karijera nakon stjecanja titule doktora znanosti. Nova istraživačka grupa, uz snažnu potporu organizacije, provest će znanstvena istraživanja te eksperimentalnim i numeričkim metodama dokazati postavljene hipoteze. Provest će se demonstracija primjene otpadnog praha i sitnih zrna recikliranih automobilskih guma u samozbijajućem betonu, izrada i ispitivanja konstrukcijskih elemenata (greda i stupova) jednakih mehaničkih i trajnosnih svojstava u usporedbi s običnim samozbijajućim betonom te razvoj novog tipa/vrste armirano-betonskog okvira poboljšane potresne otpornosti. ReCoTip projekt dodatno će ojačati znanstvene i organizacijske kapacitete kroz dvije obranjene doktorske disertacije, tri diplomska rada i provedenog jednog poslijedoktorskog usavršavanja. Ovime se jamči osiguranje provedbe strateških ciljeva organizacije kao što je razvoj karijera mladih istraživača i sudjelovanja na međunarodnim kompetitivnim pozivima za prijave projekata tijekom trajanja RecoTiP projekta. Doprinos ReCoTiP projekta razvoju znanosti bit će vidljiv kroz obranjene dvije doktorske disertacije, tri diplomska rada i provedeno poslijedoktorsko usavršavanje. Nakon završetka predloženog istraživanja na projektu ReCoTiP bit će definirane konkretne preporuke za upotrebu i primjenu praha i sitnih zrna recikliranih otpadnih automobilskih guma i ključni smjer daljnjeg područja istraživanja s obzirom na rezultate dobivene projektom.]]></summary_hr><summary_en><![CDATA[Main goal of the ReCoTip project is development of new material, selfocompacting concrete with waste tire powder,  used in load-bearing reinforced-concrete structures of the improved seismic resistance. Defined goal will be achieved by establishing the new international research group of young scientists in order to accelerate establishment of independent research careers after obtaining the PhD award. New research group will conduct scientific research via experimental and numerical methods to prove defined hypothesis with strong Organisation support. The demonstration of the use of recycled tire powder and fine particles will be carried out in the self-compacting concrete, production and testing of structural elements (beams and columns) with equal mechanic and durability properties in relation to normal self-compacting concrete, including the development of the reinforced-concrete frame with  improved earthquake resistance. ReCoTip project will further strengthen scientific and organisational capacity through the two defended PhD thesis, three master thesis and one postdoctoral specialization carried out. This guarantees strategic interest of the organisation for the successful development of the applicants&#39; career and participation in international competitive calls during ReCoTiP project implementation. Following the completion of the planned research within the project ReCoTiP, specific recommendations relating to the use and the utilization of the recycled car tire rubber powder and fine grains will be made and key direction defined for the further field of researching with regards to the results achieved by the project. ]]></summary_en></project><project>
<id>6939</id><title_hr><![CDATA[Multilinearna i nelinearna harmonijska analiza i primjene]]></title_hr><title_en><![CDATA[Multilinear and Nonlinear Harmonic Analysis and Applications]]></title_en><user_id>740</user_id><user_firstLast_name>Vjekoslav Kovač</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2017-05</proposal_call><code>UIP-2017-05-4129</code><acronim><![CDATA[MUNHANAP]]></acronim><duration>01.03.2018 - 28.02.2023</duration><status>Završio</status><financ_value>65.790,70 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Matematika, </scie_field_hr><scie_field_en>Mathematics, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>22484, 999, 21452, 22516, 864932, 865261, </team_members_id><team_members_names><![CDATA[Jelena Rupčić, Kristina Ana Škreb, Mario Stipčić, Rudi Mrazović, Aleksandar Bulj, Bruno Predojević, ]]></team_members_names><keywords_hr><![CDATA[bilinearna Hilbertova transformacija, multilinearni množitelj, ergodičko usrednjenje, Szemerédijev teorem, nelinearna Fourierova analiza]]></keywords_hr><keywords_en><![CDATA[bilinear Hilbert transform, multilinear multiplier, ergodic average, Szemerédi theorem, nonlinear Fourier analysis]]></keywords_en><summary_hr><![CDATA[Predloženi znanstveni projekt pripada grani harmonijske analize, ali ga se može smatrati interdisciplinarnim unutar polja matematike, u smislu da naša grupa namjerava riješiti nekoliko otvorenih problema iz raznovrsnih matematičkih grana, poput ergodičke teorije, aditivne kombinatorike i same harmonijske/Fourierove analize. Naš pristup će svesti te probleme na odgovarajuće kvantitativne (multilinearne ili nelinearne) ocjene u harmonijskoj analizi, koje ćemo potom dokazati analitičkim tehnikama.Prvi dio našeg projekta proučava ocjene multilinearnih integralnih formi sa zapetljanom strukturom. Ovdje namjeravamo dokazati ocjene za singularne forme pridružene hipergrafovima i pojačati poznate ocjene za multilinearne i simpleks Hilbertove transformacije. U drugom dijelu projekta proučavamo kvantitativnu konvergenciju višestrukih ergodičkih usrednjenja. Glavni ciljevi su nam omeđivanje varijacije po normi tih usrednjenja obzirom na potencije jedne transformacije, odnosno obzirom na nekoliko komutirajućih transformacija te kontrola varijacije po normi/točkama kubičnih ergodičkih usrednjenja. Treći dio bavi se teoremima Szemerédijevog tipa za podskupove euklidskog prostora s pozitivnom gustoćom te jakom verzijom Littlewoodove slutnje, usputno dokazujući odgovarajući invezni teorem. Četvrti dio projekta proučava SU(1,1) model nelinearne Fourierove analize. Karakteriziramo konvergenciju lakunarnih SU(1,1) trigonometrijskih produkata po normi i g.s. te ispitujemo uniformnu ograničenost konstanti u nelinearnoj Hausdorff-Youngovoj nejednakosti.Dakle, cjelokupni smjer našeg istraživanja je jedinstveni spoj tema međusobno povezanih specifičnim tehnikama pristupa. Neka od pitanja na koja namjeravamo dati odgovor već su dosad opsežno popularizirana u postojećoj literaturi i dokazano su teška i zanimljiva.]]></summary_hr><summary_en><![CDATA[The proposed project falls into the realm of harmonic analysis, but it can be regarded as inter-disciplinary within the field of mathematics, in the sense that our group intends to solve several open problems from diverse branches of mathematics, such as ergodic theory, additive combinatorics, and the harmonic/Fourier analysis itself. Our approach will reduce those problems to the appropriate quantitative (multilinear or nonlinear) estimates in harmonic analysis, which will then be established using the analytical techniques.The first part of our project studies estimates for multilinear integral forms with entangled structure. Here we intend to prove estimates for singular forms associated with hypergraphs and improve the current estimates for the multilinear and simplex Hilbert transforms. In the second part of the project we investigate quantitative convergence of multiple ergodic averages. The main objectives are to bound the norm-variation of those averages with respect to powers of a single transformation or with respect to several commuting transformations, and to control the norm/pointwise-variation of cubic ergodic averages. The third part deals with the Szemerédi-type theorems for positive density subsets of the Euclidean space and with the strong version of Littlewood&#39;s conjecture, proving the corresponding inverse theorem along the way. The fourth part of the project studies the SU(1,1) model of the nonlinear Fourier analysis. We characterize the norm convergence and the a.e. convergence of the lacunary SU(1,1) trigonometric products and we investigate uniform boundedness of the constants in the nonlinear Hausdorff-Young inequality.Therefore, our research theme is a unique blend of the topics related by the specific techniques of approach. Some of the questions we intend to answer have already been popularized in the existing literature and they have proven to be difficult and interesting.]]></summary_en></project><project>
<id>6940</id><title_hr><![CDATA[Interakcije slatkovodnih patogenih oomiceta i okoliša]]></title_hr><title_en><![CDATA[Interactions of freshwater pathogenic oomycetes and their environment]]></title_en><user_id>18946</user_id><user_firstLast_name>Ana Bielen</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2017-05</proposal_call><code>UIP-2017-05-6267</code><acronim><![CDATA[InteractOomyc]]></acronim><duration>01.02.2018 - 31.01.2023</duration><status>Završio</status><financ_value>248.431,39 eur</financ_value><scie_area_hr>Prirodne znanosti, Biotehničke znanosti, </scie_area_hr><scie_area_en>Natural sciences, Biotechnical sciences, </scie_area_en><scie_field_hr>Biologija, Biotehnologija, </scie_field_hr><scie_field_en>Biology, Biotechnology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prehrambeno-biotehnološki fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Food Technology and Biotechnology]]></institution_en><team_members_id>1169, 11249, 25064, 25270, 11119, </team_members_id><team_members_names><![CDATA[Tomislav Vladušić, MAJA DENT, Dora Pavić, Anđela Miljanović, Marko Nuskol, ]]></team_members_names><keywords_hr><![CDATA[patogeni oomiceti, slatkovodni rakovi, slatkovodna akvakultura, mikrobne zajednice, ekološke interakcije]]></keywords_hr><keywords_en><![CDATA[pathogenic oomycetes, freshwater crayfish, freshwater aquaculture, microbial communities, ecological interactions]]></keywords_en><summary_hr><![CDATA[U posljednja dva desetljeća globalno širenje oomicetnih patogena u slatkovodnim ekosustavima uzrokuje smanjenje brojnosti mnogih populacija. Istovremeno, oomicetni patogeni uzrokuju značajne ekonomske gubitke u slatkovodnoj akvakulturi. Unatoč tome, većina postojećih istraživanja fokusirana je na odnos domaćina i uzročnika bolesti, dok se drugi tipovi ekoloških interakcija u koje su uključeni slatkovodni oomiceti uglavnom ne uzimaju u obzir. Stoga je osnovni cilj predloženog projekta poboljšati razumijevanje ekologije oomicetnih patogena u slatkovodnim ekosustavima. Kao modelni organizmi koristiti će se dva patogena oomiceta - Aphanomyces astaci i Saprolegnia sp. A. astaci je kao uzročnik račje kuge odgovoran za nestanak brojnih populacija zavičajnih deseteronožnih rakova u Europi i time je goruća tema u području konzervacije rakova. Oomiceti iz roda Saprolegnia uzročnici su saprolegnioze - bolesti pastrve i drugih salmonidnih riba značajnih za slatkovodnu akvakulturu u Hrvatskoj i svijetu. Primjenom interdisciplinarnog pristupa u kojem će se preklopiti moderne kemijske, molekularno-biološke, mikrobiološke i bioinformatičke metode, projekt će odgovoriti na nekoliko međunarodno relevantnih i do sada neistraženih pitanja. Istražit će se utjecaj abiotskih (sastav vode) i biotskih (sastav mikrobnih zajednica) čimbenika na različite faze životnog ciklusa oomiceta. Na taj će se način predvidjeti &#39;&#39;vruće točke&#39;&#39; koje imaju povećani rizik od širenja/izbijanja bolesti uzrokovanih oomicetima u slatkovodnim ekosustavima. Osim toga, istražiti će se potencijal komenzalnih bakterijskih zajednica domaćina za inhibiciju rasta oomiceta, kao i odabranih biljnih ekstrakata koji bi se mogli primijeniti kao mjera kontrole saprolegnioze u akvakulturi. Zaključno, rezultati predloženog projekta donijet će nova fundamentalna znanja o interakcijama oomicetnih patogena i njihovog okoliša te istražiti nove metode njihove kontrole.]]></summary_hr><summary_en><![CDATA[In the last two decades, global spreading of oomycete pathogens in freshwater ecosystems is causing decline of many populations. At the same time, oomycete pathogens are also causing significant economic losses in freshwater aquaculture. Despite of this, most of the existing research is focused on host/pathogen relationship, whereas other types of ecological interactions are largely overlooked. Therefore, the main objective of the proposed project is to improve understanding of the oomycete pathogens ecology in freshwater ecosystems. Two model oomycete pathogens will be used - Aphanomyces astaci and Saprolegnia sp. A. astaci is the causative agent of crayfish plague and is responsible for the disappearance of numerous indigenous decapod crayfish populations in Europe, which makes it a hot topic in the area of crayfish conservation. Oomycetes in the genus Saprolegnia are causing saprolegniosis – a disease of trouts and other salmonid fish important for freshwater aquaculture in Croatia and globally. Using an interdisciplinary approach with complementing methods in chemistry, molecular biology, microbiology and bioinformatics, the project will try to answer on several so far unexplored and internationaly relevant issues. The effect of abiotic (water composition) and biotic (microbial communities composition) factors on different oomycetal life cycle stages will be investigated. In that manner „hot spots“ in freshwater ecosystem will be predicted, having increased risk for outbreak/spreading of diseases caused by oomycete pathogens. In addition, the potential of hosts comensal bacterial communities and selected plant extracts to inhibit the growth of oomycetes will be investigated, as well as their potential application in controlling saprolegniosis in aquaculture. In summary, results of the proposed project will bring about new basic knowledge about oomycete pathogens interaction with their environment, and asses new methods for their control. ]]></summary_en></project><project>
<id>6948</id><title_hr><![CDATA[Fraktalna analiza diskretnih dinamičkih sustava]]></title_hr><title_en><![CDATA[Fractal analysis of discrete dynamical systems]]></title_en><user_id>2709</user_id><user_firstLast_name>Maja Resman</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2017-05</proposal_call><code>UIP-2017-05-1020</code><acronim><![CDATA[DSfracta]]></acronim><duration>15.10.2018 - 14.10.2023</duration><status>Završio</status><financ_value>149.869,27 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Matematika, </scie_field_hr><scie_field_en>Mathematics, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>2932, 26243, </team_members_id><team_members_names><![CDATA[Goran Radunović, Dino Peran, ]]></team_members_names><keywords_hr><![CDATA[diskretni dinamički sustavi, klasifikacije fiksnih točaka, Dulacove klice, fraktalne zeta funkcije, teorija kompleksnih dimenzija]]></keywords_hr><keywords_en><![CDATA[discrete dynamical systems, classifications of fixed points, Dulac germs, fractal zeta functions, theory of complex dimensions]]></keywords_en><summary_hr><![CDATA[Cilj projekta je uspostava nove istraživačke grupe s novim smjerom istraživanja. Naglasak je na povezivanju dosadašnjih područja istraživanja članova tima: namjera nam je povezati kvalitativnu teoriju dinamičkih sustava i teoriju kompleksnih dimenzija fraktalnih skupova, kroz fraktalnu analizu orbita sustava. Pod pojmom fraktalnih svojstava orbita podrazumijevamo njihovu box dimenziju i generalizacije. Motivirani smo tzv. ‘inverznim pitanjem’: možemo li dobiti informaciju o ponašanju sustava fraktalnom analizom jedne jedine trajektorije sustava? Kompleksne dimenzije fraktalnog skupa generalizacije su njegove box dimenzije i preciznije otkrivaju geometrijsku strukturu skupa.  Analiza kompleksnih dimenzija orbita čini se dobro prilagođenom mjerenju složenosti sustava. Teorija kompleksnih dimenzija temelji se na analizi singulariteta kompleksnih funkcija (fraktalnih zeta funkcija koje je uveo Lapidus). To je samo po sebi zanimljivo područje, povezano sa spektralnom teorijom, matematičkom fizikom i teorijom brojeva (poznata Riemannova hipoteza). Namjera nam je primijeniti tu teoriju na važna pitanja u diskretnim dinamičkim sustavima, kao što je npr. klasifikacija sustava. Ukratko, ključne točke istraživanja su: klasifikacija (formalna ili analitička) 1-dimenzionalnih diskretnih sustava preko kompleksnih dimenzija njihovih orbita, te opisivanje bifurkacija sustava preko skupa kompleksnih dimenzija orbita. Cilj nam je i promicanje područja dinamičkih sustava u Hrvatskoj organiziranjem radionice i mini-kurseva. Planiramo proširiti i ojačati našu malu grupu zapošljavanjem novog doktoranda i poslijedoktoranda. U Hrvatskoj postoji samo mala, nedovoljno povezana grupa istraživača u području dinamičkih sustava, koju namjeravamo jače povezati. Tijekom provedbe projekta, poseban naglasak stavit ćemo na znanstveni razvoj doktoranda. Namjeravamo mu pružiti mogućnost međunarodne suradnje od samog početka karijere.]]></summary_hr><summary_en><![CDATA[The goal of the project is the formation of a new research group around a new research direction. It is meant as an interplay of areas of the team members: we plan to relate the qualitative theory of dynamical systems with the theory of complex dimensions of fractal sets, through fractal analysis of orbits. By fractal properties of orbits, we mean their box dimension and generalizations. We are motivated by the ‘inverse question’: can we extract information on the behavior of a system by fractal analysis of a single trajectory? The complex dimensions of fractal sets generalize the notion of their box dimension and reveal  the geometrical structure more precisely. Analysing complex dimensions of orbits seems to be well-adaptedto measuring the complexity of the system. The theory of complex dimensionsis based on the analysis of singularities of complex functions (fractal zeta functions introduced by Lapidus). It is a very interesting field in itself, related to spectral theory, mathematical physics and number theory (the well-known Riemann hypothesis).We plan to apply this theory to important questions in discrete dynamical systems, such as their classifications. In short, key points of the research are: classifications (formal and analytic) of 1-dim discrete systems through complex dimension analysis of attached orbits, and understanding their bifurcations by the set of complex dimensions of attached orbits. Our aim is also to promote the field of dynamical systems in Croatia by organizing a workshop and mini-courses. We plan to expand our small group by engaging a new PhD student and a postdoc. In Croatia, there is only a small group of researchers in dynamical systems, scattered in different areas, which we intend to bring closer together.  In the course of the project, we will put a particular effort in scientific growth of the new PhD student. We plan to provide her/him with the opportunity of international collaborations from the beginning of her/his career.]]></summary_en></project><project>
<id>6950</id><title_hr><![CDATA[Bolničke zaštitne tekstilije]]></title_hr><title_en><![CDATA[Hospital Protective Textiles]]></title_en><user_id>5211</user_id><user_firstLast_name>Sandra Flinčec Grgac</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2017-05</proposal_call><code>UIP-2017-05-8780</code><acronim><![CDATA[HPROTEX]]></acronim><duration>15.03.2018 - 14.09.2023</duration><status>Završio</status><financ_value>231.344,35 eur</financ_value><scie_area_hr>Tehničke znanosti, Biomedicina i zdravstvo, Biotehničke znanosti, </scie_area_hr><scie_area_en>Technological sciences, Biomedicine and health sciences, Biotechnical sciences, </scie_area_en><scie_field_hr>Tekstilna tehnologija, Farmacija, Biotehnologija, </scie_field_hr><scie_field_en>Textile technology, Pharmaceutical sciences, Biotechnology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Tekstilno-tehnološki fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Textile Technology]]></institution_en><team_members_id>3088, 4810, 4643, 2830, 22753, 22751, 19372, 3057, 22774, 25049, 26302, 865428, </team_members_id><team_members_names><![CDATA[Anita Tarbuk, Tihana Dekanić, Snježana Brnada, Ivana Kmetič, Jasna Jablan, Katia Grgić, Franka Žuvela Bošnjak, Teuta Murati, Marina Miletić, Rajna Malinar, Ivana Čorak, Ana Vrbić Vrbić, ]]></team_members_names><keywords_hr><![CDATA[generiranje tekstilne prašine, bolničke tekstilije, celulozne tkanine, kationiziranje, međupovršinske pojave, praćenje umrežavanja, postojane obrade]]></keywords_hr><keywords_en><![CDATA[textile dust generating, hospital textiles, cellulosic fabrics, cationization, interface phenomena, crosslinking monitoring,  durable  treatments]]></keywords_en><summary_hr><![CDATA[Glavni ciljevi projekta su uspostava interdisciplinarne istraživačke skupine, uključujući i mladog istraživača doktoranda, i Laboratorija za kontrolirano praćenje procesa umrežavanja, čime će se omogućiti sustavno istraživanje i prijenos znanja usmjerenih rješavanju problema pojave tekstilne prašine, potencijalnog prijenosnika zaraza i uzročnika kvarova uređaja u bolničkom okruženju. Proizvest će se tkanine od pređa iz pamuka (CO) i pamuk/poliestera (CO/PES) u svrhu istraživanja utjecaja konstrukcije pređe, veza i tkanine na generiranje tekstilne prašine prije i nakon provedenih ciklusa pranja. Razvijat će se i definirati uvjeti kationiziranja i antimikrobne dorade s kvarternim amonijevim spojevima, ß-ciklodekstrinima s inkapsuliranim antimikrobnim sredstvom i kitozanom u svrhu postizanja postojanosti na višestruke cikluse održavanja, a s ciljem minimalnog kemijskog i mehaničkog oštećenja što doprinosi manjem otpuštanju tekstilne prašine. Uspostavom Laboratorija detaljno će se istražiti sorpcija kupelji sa sredstvima za antimkrobnu obradu na tkanine primarno uzevši u obzir međupovršinska svojstva (DSA30S) i in situ praćenju utjecaja topline na fizikalno-kemijske promjene (FTIR-ATR GG) s ciljem preciznog definiranja sastava kupelji i procesnih parametra za postizanje postojanog umrežavanja. Promjene u CO i CO/PES tkaninama tijekom i nakon obrade, te višestrukih ciklusa održavanja, istražit će se na kristaliničnoj, fizikalno-kemijskoj i morfološkoj razini te analizom međupovršina primjenom FE-SEM, TGA, FTIR, XRD, MCC, GS-MS, EKA, SFE, CA, MMT, WRV, UV-VIS spektrofotometrijom. Novorazvijenim tkaninama ispitat će se toksičnost, te će se u skladu s dobivenim rezultatima predložiti njihova ciljana primjena u bolničkom okruženju uz prijedlog formulacije deterdženata i postupaka za njihovo održavanje. Pronalaženje i implementacija novih ideja bit će usmjerena prema poduzetništvu u svrhu poticanja gospodarskog rasta te daljnjim istraživanjima u okviru nove projektne prijave]]></summary_hr><summary_en><![CDATA[The project main goals are establishing of interdisciplinary research group, with young doctoral researcher, and Laboratory for Controlled Monitoring of the Crosslinking Process, enabling systematic research and knowledge transfer to solve the problem of generating textile dust, a disease carrier and instrument stoppage causer, in the hospital environment. The textile fabrics of cotton fibers (CO) and their polyester blends (CO/PES) will be produced. The influence of yarn, weave and fabric construction to the generating of textile dust before and after washing cycles will be researched. The conditions of cationization and antimicrobial finishing with quaternary ammonium compounds, ß-cyclodextrins with encapsulated antimicrobial agents, and chitosan will be developed to achieve permanency to textile care with minimizing chemical and mechanical damage, thereby contributing to a lower release of textile dust. By setting up a Laboratory, the fabric sorption of the bath with antimicrobial agents will be investigated through interfacial properties (DSA30S), and in situ heat-monitoring (FTIR-ATR GG) of physical-chemical change in fabric will be performed, in order to precisely define the bath composition and process parameters to achieve durable crosslinking. The change in CO and CO/PES during and after treatment, and after the textile care cycles, will be analyzed on crystalline, physico-chemical, morphological and interfacial level using FE-SEM, TGA, FTIR, XRD, MCC, GS-MS, EKA, SFE, CA, MMT, WRV, UV-VIS spectrophotometry. For the purpose of health and environment protection, all newly developed fabrics will be tested on toxicity and, according to the obtained results, their usage in the hospital environment with the proposal of detergent formulations and procedures for their care will be suggested. The finding and implementation of new ideas will be directed towards entrepreneurship with the aim of economic growth, and further research within new project application.]]></summary_en></project><project>
<id>6958</id><title_hr><![CDATA[Zelene tehnologije u sintezi heterocikličkih spojeva]]></title_hr><title_en><![CDATA[Green Technologies in Synthesis of Heterocyclic Compounds]]></title_en><user_id>11301</user_id><user_firstLast_name>Maja Molnar</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2017-05</proposal_call><code>UIP-2017-05-6593</code><acronim><![CDATA[GREENNESS]]></acronim><duration>01.01.2018 - 31.12.2022</duration><status>Završio</status><financ_value>190.382,74 eur</financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Prehrambena tehnologija, </scie_field_hr><scie_field_en>Food technology, </scie_field_en><institution_hr><![CDATA[Sveučilište Josipa Jurja Strossmayera u Osijeku, Prehrambeno-tehnološki fakultet]]></institution_hr><institution_en><![CDATA[Josip Juraj Strossmayer University of Osijek, Faculty of Food Technology]]></institution_en><team_members_id>22632, 2735, 19387, 25728, 29593, </team_members_id><team_members_names><![CDATA[Mario Komar, Valentina Bušić, Melita Lončarić, Mirjana Prkačin, Martina Jakovljević, ]]></team_members_names><keywords_hr><![CDATA[eutektička otapala, zelena sinteza, kinazolinoni, Knoevenagelova kondenzacija, rodanin, piridin, 2,4-tiazolidindioni]]></keywords_hr><keywords_en><![CDATA[deep eutectic solvents, green synthesis, quinazolinone, Knoevenagel condensation, rhodanine, pyridine]]></keywords_en><summary_hr><![CDATA[Zelene metode sinteze u organskoj kemiji posljednjih godina postaju sve popularnije među znanstvenicima, koji ovim ekološki prihvatljivim načinom pokušavaju zamijeniti konvencionalne metode sinteze. Sinteza u eutektičkim otapalima, kao i sinteza uz pomoć mikrovalova su danas vrlo zastupljene u organskoj kemiji i mogu se okarakterizirati kao „zelene metode“ zbog malog utroška energije, kratkog reakcijskog vremena, upotrebi netoksičnih otapala, itd. Nadalje, eutektička otapala su netoksična i okolišno prihvatljiva otapala, lako se sintetiziraju iz biorazgradivih komponenti i pokazuju brojne prednosti u odnosu na konvencionalna organska otapala. Upravo zbog navedenih prednosti u odnosu na konvencionalne metode sinteze, osobito vezano za utjecaj na okoliš i ekološki aspekt, ove metode će se koristiti za sintezu nekih keterocikličkih spojeva na bazi kumarna, kinazolinona i piridina s potencijalnom biološkom aktivnošću.Glavni cilj ovog projekta je razviti ekološki prihvatljive metode sinteze važnih bioaktivnih heterocikličkih spojeva. Projekt će se uključivati 1) Sintezu derivata kinazolinona, 2) Knoevenagelovu kondenzaciju i 3) Sintezu derivata piridina, reakcije koje se svakodnevno provode u brojnim istraživačkim laboratorijima. Svakodnevno provođenje ovih reakcija konvencionalnim putem uzrok je povećanoj upotrebi, generiranju i odlaganju štetnih tvari, što ima golem negativan učinak na okoliš. Zelene metode u ovom slučaju su više nego dobrodošle. Stoga će se sve gore opisane reakcije optimirati i provesti u eutektičkim otapalima, uz miješanje i grijanje ili u kombinaciji s mikrovalovima i ultrazvukom. Na projektu će raditi dva doktoranda, u okviru svojih tema doktorskog rada, svaki na specifičnoj vrsti spojeva.]]></summary_hr><summary_en><![CDATA[Green methods in organic synthesis have been of interest for many chemists nowadays since there is a tendency of developing environmentally friendly and acceptable synthetic routes. Synthesis in deep eutectic solvents and microwave synthesis is often characterized as “green” due to their low energy consumption, short reaction times, use of non-toxic solvents, etc. Moreover, deep eutectic solvents are nontoxic and environmentally acceptable, easily synthesized from biodegradable components and show numerous advantages compared to conventional organic solvents. Therefore, due to their advantages compared to conventional synthesis, emphasising the environment safety and ecological issues, those methods will be employed in synthesis of some coumarin, quinazolinone and pyridine heterocyclic compounds with potential biological activity. The main goal of this project is to develop procedures for synthesis of various biologically active and important heterocycles using green technologies. This project will be performed considering three (3) aspects; 1) Synthesis of quinazolinone derivatives, 2) Knoevenagel condensation and 3) Synthesis of pyridine derivatives. All of these reactions are mostly performed conventionally and are very common in chemical laboratories, utilized in every day work of many researchers. Due to their daily performance, many toxic organic chemicals and solvents are spent, generated and disposed, causing an inormous impact on environment. Green technologies in this regard are more than welcomed. Therefore, all reactions described above will be optimized and performed in deep eutectic solvents, with stirring and heating, microwaves and ultrasound. Two doctoral students will be working on this project, each one of them dealing with specific type of compounds or reactions and it is expected that they gain their PhD diploma within this project. ]]></summary_en></project><project>
<id>6960</id><title_hr><![CDATA[Visokokvalitetna strojna tvorba govora za hrvatski jezik]]></title_hr><title_en><![CDATA[High-Quality Speech Synthesis for Croatian Language]]></title_en><user_id>4895</user_id><user_firstLast_name>Marin Vuković</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2017-05</proposal_call><code>UIP-2017-05-6917</code><acronim><![CDATA[HR-SYNTH]]></acronim><duration>01.05.2018 - 30.04.2023</duration><status>Završio</status><financ_value>125.033,61 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Elektrotehnika, Računarstvo, </scie_field_hr><scie_field_en>Electrical engineering, Computer sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id>5345, 25406, </team_members_id><team_members_names><![CDATA[Damjan Katušić, Renato Šoić, ]]></team_members_names><keywords_hr><![CDATA[strojna tvorba govora, sinteza govora, hrvatski jezik, primjena strojne tvorbe govora, generativni modeli]]></keywords_hr><keywords_en><![CDATA[speech synthesis, machine based speech synthesis, Croatian, speech synthesis applications, generative models]]></keywords_en><summary_hr><![CDATA[Strojna tvorba govora u informacijsko-komunikacijskoj tehnologiji prisutna je već dugi niz godina. Međutim, visokokvalitetna rješenja, koja su u mogućnosti savladati specifične i manje učestale jezične sintakse, su vrlo rijetka čak i za najzastupljenije svjetske jezike kao što su engleski i španjolski. Hrvatski je jezik, u kontekstu strojne tvorbe govora, vrlo složen i znatno složeniji od, primjerice, engleskog. Vjerojatno je i to jedan od razloga što za hrvatski jezik još ne postoji visokokvalitetna strojna tvorba govora. Promatrajući velike potencijale strojne tvorbe govora u mnogim područjima primjene, za koja postoje rješenja za najzastupljenije svjetske jezike, nameće se potreba za visokokvalitetnom strojnom tvorbom govora za hrvatski jezik. Kako bi se osigurala uspješna provedba predloženog projekta, osnovat će se istraživačka grupa sa zadaćama provedbe projekta, ostvarenja vidljivosti istraživačke grupe te diseminacijom znanja i rezultata projekta. Diseminacija rezultata je ključna za daljnje povezivanje s domenskim stručnjacima i istraživačima kako bi se osigurala održivost istraživanja te evolucija rješenja za strojnu tvorbu govora i nakon završetka predloženog projekta. Predloženi projekt ima više ciljeva, no prije svega je potrebno sustavno istražiti i evaluirati postojeće metode strojne tvorbe govora za sve jezike s naglaskom na jezicima sličnim hrvatskom jeziku. Na temelju istraživanja će se predložiti razvoj novih metoda koje bi mogle savladati specifičnosti hrvatskog jezika u kontekstu strojne tvorbe govora. Predložene metode će se implementirati u integrirano rješenje za strojnu tvorbu govora za hrvatski jezik u distribuiranoj i centraliziranoj okolini na odabranim područjima primjene. U konačnici, provest će se evaluacija razvijene strojne tvorbe govora kako bi se osiguralo visokokvalitetno rješenje koje će dugoročno moći zadovoljiti potrebe strojne tvorbe govora, evoluciju i primjenu na različitim područjima i nakon završetka predloženog projekta.]]></summary_hr><summary_en><![CDATA[Speech synthesis has been present in ICT domain for many years. However, high-quality solutions that can overcome specific and less common language syntax are rare, even for widespread languages such as English and Spanish. Croatian language is rather complex in the context of speech synthesis. Probably this is one of the reasons why there is still no high-quality speech synthesis for Croatian. When observing the great potential of speech synthesis in various application areas, which have several solutions for widespread languages, the need for Croatian speech synthesis becomes obvious. To ensure the successful implementation of the proposed project, a research group needs to be established with the tasks of project management, achieving visibility of the research group and dissemination of results of the project. Dissemination of project results is essential for further connecting with domain experts and researchers to ensure the sustainability of research and evolution of the proposed solution for speech synthesis, during and after the completion of the proposed project. The proposed project has several objectives, but above all it is first necessary to systematically analyse and evaluate existing methods of speech synthesis for all languages with an emphasis on languages like Croatian. The results of analysis and evaluation will help form a decision regarding implementation of new methods that could overcome the issues of Croatian language in the context of speech synthesis. The proposed methods will be implemented as an integrated solution for speech synthesis of the Croatian language in a distributed and centralised environment, on selected application areas. Finally, evaluation of the developed speech synthesis will be performed to ensure high-quality of the solution that will be able to meet the needs of speech synthesis in the long-term, as well as evolution and application in various fields during and after the completion of the proposed project.]]></summary_en></project><project>
<id>6962</id><title_hr><![CDATA[Modeli i inverzne metode za elektromagnetske senzore u bliskom polju]]></title_hr><title_en><![CDATA[Models and inverse methods for near field electromagnetic sensors]]></title_en><user_id>12596</user_id><user_firstLast_name>Darko Vasić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2017-05</proposal_call><code>UIP-2017-05-6948</code><acronim><![CDATA[MIMES]]></acronim><duration>05.02.2018 - 04.07.2023</duration><status>Završio</status><financ_value>136.834,18 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Elektrotehnika, Računarstvo, </scie_field_hr><scie_field_en>Electrical engineering, Computer sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id>19300, 22790, 22765, 24508, 28628, </team_members_id><team_members_names><![CDATA[Davorin Ambruš, Robert Tutić, Matija Nestić, Dorijan Špikić, Ivan Rep, ]]></team_members_names><keywords_hr><![CDATA[senzori, elektronički sustavi, ugrađeni računalni sustav, inverzni problemi, elektromagnetski modeli, EM polje, blisko polje, nerazorno ispitivanje]]></keywords_hr><keywords_en><![CDATA[sensors, electronic systems, embedded systems, inverse problems, electromagnetic modelling, EM field, near field, nondestructive testing]]></keywords_en><summary_hr><![CDATA[Elektromagnetski senzori s radnim područjem u bliskom polju (eng. near field electromagnetic sensors, NFEMS) se temelje na promjenama električnog i magnetskog polja uslijed promjena u svojstvima materijala ili geometrije bliskih objekata ili procesa. NFEMS koji rade na frekvencijama do 10 MHz se mogu razvrstati prema dominantnom mehanizmu sprege na kapactivne (električna sprega) i induktivne (magnetska sprega). Aplikacije NFEMS-a su brojne zahvaljujući njihovoj neinvazivnosti, osjetljivosti, jednostavnosti i robusnosti. Uslijed rada u bliskom polju njihov najveći nedostatak je kompliciran odnos između mjerenih veličina (jakost polja, inducirani napon, impedancija) i ispitivanih svojstava (materijal, dimenzije, inkluzije i sl.). U pravilu, napredne primjene NFEMS-a zahtijevaju nepraktične računalno intenzivne inverzne procedure kako bi se dobio podatak pogodan za ljudsku upotrebu. Posljedično, aplikacije se oslanjaju na simplificirane modele za inverziju ili na ljudsku interpretaciju.Glavni cilj projekta je uspostava istraživačke grupe u području NFEMS-a uključujući senzorske tehnologije i sučelja, ugrađene računalne senzorske sustave, modeliranje i inverzne metode. U okviru projekta, istraživačka grupa će proučavati računalno efikasne modele NFEMS-a u području nerazornog ispitivanja cijevi i ispitivanja tla. Ova područja pokrivaju dva vrlo različita skupa materijala (vrlo vodljivi, magnetski i homogeni s inkluzijama, odnosno slabo vodljivi, dielektrični i heterogeni), pa će se istražiti različiti pristupi modeliranju te ekstrahirati zajedničke spoznaje. Istraživačka grupa će također proučavati inverzne metode zasnovane na razvijenim modelima te će eksperimentalno demonstrirati istraživane koncepte u dvije industrijski relevantne primjene. Radi ostvarivanja ciljeva projekta, grupa će razvijati napredna senzorska sučelja i ugrađene računalne sustave velike osjetljivosti, točnosti, raspoloživih računalnih resursa i sposobnosti za rad u otežanim uvjetima.]]></summary_hr><summary_en><![CDATA[Near field electromagnetic sensing (NFEMS) modality is based on the changes of electric and magnetic fields due to changes in material properties and geometry of nearby objects or processes. NFEMS operating below 10 MHz can be classified according to the dominant coupling as capacitive (electric coupling) and inductive (magnetic coupling) and they find their use in a vast number of sensing applications thanks to their non-intrusiveness, sensitivity, simple construction and robustness. Because of near field operation their greatest shortcoming is complicated relationships between measured quantities (field strength, induced voltage or impedance) and inspected properties (material properties, dimensions, inclusion, etc.). As a rule, advanced applications of NFEMS require impractical computationally-intensive inversion procedures to obtain human-suited information. Consequently, they rely either on simplified models for the inversion or on human interpretation.The overall objective of the project is to establish a research group in NFEMS including sensor technologies and interfaces, embedded sensor systems, modelling and inverse methods. During the project the group will study computationally efficient models for NFEMS in the domains of non-destructive testing of tubes and proximal soil sensing. These applications include two very different set of material properties (high conductive, magnetic, homogenous with small inclusions vs. low conductive, dielectric and heterogeneous) so different modelling approaches can be tested and complementary knowledge gained. The team will also study inverse methods based on the implemented models and will experimentally demonstrate the researched concepts on two industry-relevant applications. In order to accomplish the project&#39;s objectives, the group will engineer novel electromagnetic sensor interfaces and embedded systems with high performance in terms of sensitivity, accuracy, processing power and harsh environment deployment.]]></summary_en></project><project>
<id>6964</id><title_hr><![CDATA[Laboratorij za geoprostorne analize]]></title_hr><title_en><![CDATA[Geospatial analysis laboratory]]></title_en><user_id>12395</user_id><user_firstLast_name>Ante Šiljeg</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2017-05</proposal_call><code>UIP-2017-05-2694</code><acronim><![CDATA[GAL / GAL]]></acronim><duration>06.03.2018 - 05.03.2023</duration><status>Završio</status><financ_value>181.228,88 eur</financ_value><scie_area_hr>Prirodne znanosti, Tehničke znanosti, Biotehničke znanosti, Humanističke znanosti, </scie_area_hr><scie_area_en>Natural sciences, Technological sciences, Biotechnical sciences, Humanities, </scie_area_en><scie_field_hr>Geografija, Geodezija, Poljoprivreda, Arheologija, </scie_field_hr><scie_field_en>Geography, Geodesy, Agriculture, Archeology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zadru]]></institution_hr><institution_en><![CDATA[University of Zadar]]></institution_en><team_members_id>22550, 22505, 19329, 22716, 21333, 3097, 25334, 865137, 22524, </team_members_id><team_members_names><![CDATA[Fran Domazetović, Ivan Marić, Vedrana Glavaš, Ivan Plaščak, Luka Babić, Nina Lončar, Mirko Barada, Lovre Panđa, Neda Kulenović, ]]></team_members_names><keywords_hr><![CDATA[daljinska istraživanja, GIS, LiDAR, morfometrijske analize, UAV, višekriterijske analize]]></keywords_hr><keywords_en><![CDATA[GIS, LiDAR, morphometric analysis, multi-criteria decision analysis, remote sensing, UAV]]></keywords_en><summary_hr><![CDATA[Osnovni  cilj projekta  je uspostava  Laboratorija  za geoprostorne analize  (GAL)  pri  Odjelu  za  geografiju  Sveučilišta  u  Zadru  te  okupljanje  interdisciplinarnog  tima  znanstvenika  iz  različitih  znanstvenih  polja (geografija,  arheologija, geodezija, agronomija). Osnovna  svrha GAL-a  je  provođenje  znanstvenih  istraživanja,  edukacija  mladih  istraživača, primjena novih znanja i tehnologija te razvoj  inovativnih metoda istraživanja. Prva faza uspostave usmjerena je na opremanje laboratorija s najsuvremenijim  uređajima  uz istovremeno usavršavanje istraživačkog  tima. Primjenom GIS-a u kombinaciji sa korištenjem tehnologije daljinskih istraživanja (bespilotna letjelica, 3D-skener, LiDAR, infracrvena kamera, termalna kamera itd.) omogućava se proučavanje određenog procesa  ili pojave u krupnom mjerilu, pri čemu su sve karakteristike promatranog objekta mjerljivo, odnosno kvantitativno opisane. Stoga je drugi cilj ovog projekta usmjeren na primjenu geoprostornih analiza u primijenjenim istraživanjima kroz  (a)  razvoj   višekriterijskog   modela  održivog  upravljanja   na  području  sedrotvornih vodotoka (b) razvijanje novog metodološkog pristupa u proučavanju  jaruga i (c)  pronalaženje  praktičnih  rješenja  kroz  primjenu  geoprostornih  analiza  u arheologiji i agronomiji. Ostvarenje navedenih ciljeva i izvedeni rezultati pokazali bi primjenjivost i opravdanost laboratorija u daljnjim znanstvenim istraživanjima. Jedinstveni doprinos ostvarenja ovog projekta očituje se u tome da bi GAL predstavljao prvi laboratorij za geoprostorne analize u RH koji će biti usmjeren na usavršavanje te promociju i edukaciju mladih znanstvenika kroz njihovo uključivanje u rad laboratorija. Znanstveni doprinos ovog istraživanja iskazati će se kroz pisanje dvije doktorske disertacije, čiji je osnovni cilj istraživanja izrada prvog plana održivog upravljanja sedrotvornim vodotocima te razvoj novog metodološkog koncepta za proučavanje jaruga. ]]></summary_hr><summary_en><![CDATA[The main aim of the project is to set up a Geospatial Analysis Laboratory (GAL) at the Department of Geography, University of Zadar, and to gather an interdisciplinary team of scientists from various fields (geography, archaeology, geodesy, agronomy). GAL&#39;s basic aim is to produce scientific research, educate young researchers, apply new knowledge and technology, and develop innovative research methods. The first phase of the application focuses on equipping the laboratory with the most up-to-date devices and accompanying software, while training the research team. The use of GIS in combination with RS technology (unmanned aerial vehicle, 3D scanner, LiDAR, infrared camera, thermal camera, etc.) facilitates the study of certain processes or phenomena at close range, while their characteristics are measurable, i.e. can be described quantitatively. Therefore, the second goal of the project focuses on the application of geospatial analyses in applied research through (a) the development of multicriteria models of sustainable management in the area of tufa-forming watercourses, (b) the development of a new methodical approach to studying gullies, and (c) discovering practical solutions through applying geospatial analyses in archaeology and agronomy. Achieving these goals and the results produced would demonstrate to applicability of and justification for GAL in further scientific research. The unique contribution of this project would be the creation of the first laboratory for geospatial analysis in Croatia, focusing on training, promoting and educating young scientists by engaging them in its work. The scientific contribution of this research will be seen in two doctoral dissertations, whose basic research topics are concerned with the production of the first plan for the sustainable management of tufa-forming watercourses, and the development of a new methodological concept for studying gullies. ]]></summary_en></project><project>
<id>6965</id><title_hr><![CDATA[Fotopobuđenja u 2D poluvodičima]]></title_hr><title_en><![CDATA[Photoexcitations in 2D semiconductors]]></title_en><user_id>6225</user_id><user_firstLast_name>Nataša  Vujičić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2017-05</proposal_call><code>UIP-2017-05-3869</code><acronim><![CDATA[PhotoExcite(2)D]]></acronim><duration>01.03.2018 - 28.02.2023</duration><status>Završio</status><financ_value>201.101,60 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, </scie_field_hr><scie_field_en>Physics, </scie_field_en><institution_hr><![CDATA[Institut za fiziku]]></institution_hr><institution_en><![CDATA[Institute of Physics in Zagreb]]></institution_en><team_members_id>19881, 22752, 22768, 28810, </team_members_id><team_members_names><![CDATA[Borna Pielić, Valentino Jadriško, Luca Moretti, Ana Senkić, ]]></team_members_names><keywords_hr><![CDATA[2D materijali, dihalkogenidi prijelaznih metala, ekscitoni, fotopobuda, vremenski razlučiva mjerenja, fotoluminiscencija, Raman spektroskopija]]></keywords_hr><keywords_en><![CDATA[2D materials, transition metal dichalcogenides, excitons, photoexcitations, time resolved measurements, photoluminescence, Raman spectroscopy]]></keywords_en><summary_hr><![CDATA[Glavni cilj ovog projektnog prijedloga je razvoj naprednih optičkih istraživanja dvodimenzionalnih (2D) poluvodičkih materijala poput dihalkogenida prijelaznih metala (TMDs) i njihovih iznimnih svojstava koja se ispoljavaju kao rezultat interakcije svjetlosti i materije. Ta interakcija, ne samo da otkriva elektronsku strukturu tih materijala, već može biti izniman način da se razumiju njihova strukturna svojstva. Iako je načinjen značajan pomak u istraživanju vlastitih ekscitonskih stanja monoslojeva (1L) TMDs, ta istraživanja se još uvijek intenzivno diskutiraju među teoretičarima, koji pak vape za eksperimentalnom potvrdom. Mjerenjem emisijskih spektara u različitim eksperimentalnim uvjetima, na sobnim i niskim temperaturama, izučavat ćemo elementarna pobuđenja u 2D poluvodičima koja su vrlo važna u fizici mnoštva čestica, koje je postalo vrlo atraktivno istraživačko područje upravo zbog toga što istražuje osnove kvantne mehanike.Još je jedan zaštitni znak 1L TMDs materijala, a to je tzv. vezanje spina i doline koje vodi do dolinski osjetljivih optičkih prijelaza između vrpci. Optičkom pobudom, uz pravilni odabir kiralnih pravila (uslijed narušavanja centralne simetrije), može se ostvariti obećavajuće svojstvo tih materijala za buduću primjenu u spintronici te valleytronici. Planiramo iskoristit našu mogućnost proizvodnje vertikalnih struktura iz 2D slojeva s ciljem utvrđivanja sistematične povezanosti između optičkog odziva i sastava slojeva u takvim materijalima te njihove međusobne orijentacije, primjenom čitavog niza inovativnih optičkih tehnika. Naš projekt će koristiti činjenicu da je na našem institutu razvijena tehnika sinteze uzoraka bazirana na depoziciji iz kemijskih para (CVD). Predloženi istraživački projekt i njegovi znanstveni ciljevi dobro se uklapaju u okvire međunarodno prepoznatljivog i relevantng znanstvenog rada, s odličnom perspektivom za uspjeh, ako imamo na umu njegovu uključenost u velike institutske projekte.]]></summary_hr><summary_en><![CDATA[The main goal of this proposal is advanced optical investigation of two-dimensional (2D) semiconductor materials such as transition metal dichalcogenides (TMDs) and their exceptional properties that emerge upon light-matter interaction. Not only that this interaction reveals electronic structure of such materials, but it can be an excellent tool for investigation of their structural properties. Though much progress has been made, intrinsic excitonic states of 1L TMDs are still highly debated in theory which craves for direct experimental determination. By measuring emission spectra in various experimental conditions in a controllable manner at both room and cryogenic temperatures we will explore elementary excitations in 2D semiconductors which are essential for many-body interactions study that become a very exciting research field for exploring fundamentals of quantum mechanics. Another trademark of monolayer (1L) TMDs is their valley-spin coupling which leads to a valley dependant helicity of interband optical transitions. Optical excitation using the chiral selection rules arising from 1L TMDs unique (a)symmetry is one route to obtain promising nanoscale systems for future spintronic and valleytronic applications. Our ability to vertically assemble 2D layers will be exploited with the aim to establish a systematic relationship between the optical response and heterostructure composition and stacking alignment between individual layers with innovative combination of various experimental techniques. Our project will benefit from the expertise in sample synthesis that has been established at the Institute based on controllable chemical vapor deposition (CVD) technique. Proposed research and its objectives fit well into the framework of internationally recognized and relevant scientific work, with the excellent perspective for success having in mind its involvement in major projects located at Institute of Physics.]]></summary_en></project><project>
<id>6968</id><title_hr><![CDATA[Klimatske promjene i varijabilnost u Hrvatskoj – od globalnih utjecaja do lokalnih zelenih rješenja]]></title_hr><title_en><![CDATA[Croatian climate variability and change – from global impacts to local green solutions]]></title_en><user_id>2650</user_id><user_firstLast_name>Ivana Herceg Bulić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2017-05</proposal_call><code>UIP-2017-05-6396</code><acronim><![CDATA[CroClimGoGreen]]></acronim><duration>15.02.2018 - 15.08.2023</duration><status>Završio</status><financ_value>196.111,22 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Geofizika, </scie_field_hr><scie_field_en>Geophysics, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>2635, 22511, 25094, 29394, 3137, 862800, </team_members_id><team_members_names><![CDATA[Melita Perčec Tadić, Irena Nimac, Sara Ivasić, Matej Žgela, Mladen Maradin, Marijana Boras, ]]></team_members_names><keywords_hr><![CDATA[urbani toplinski otok, klimatsko modeliranje, mjere ublažavanja, zelena i plava infrastruktura, Hrvatska]]></keywords_hr><keywords_en><![CDATA[urban heat island, climate modelling, mitigation measures, green and blue infrastructure, Croatia]]></keywords_en><summary_hr><![CDATA[Urbani razvoj bitno mijenja obilježja Zemljine površine i atmosfere te se pritom generiraju posebni klimatski uvjeti u urbanim sredinama - urbana klima. Nju karakterizira stvaranje urbanog toplinskog otoka (UHI, eng. Urban Heat Island), tj. bitno viša temperatura zraka u urbanom području u odnosu na okolno ruralno područje. UHI je značajan ekološki problem povezan s mnogim negativnim posljedicama (zagrijavanje podloge, nepovoljni klimatski uvjeti u gradu, povećan zdravstveni rizik, povećane potrebe za vodom, povećana potrošnja energije itd.). Projekt je usmjeren na proučavanje urbane klime, klimatske varijabilnosti i manifestacija klimatskih promjena u Hrvatskoj te njihovog utjecaja na urbani okoliš, a može se podijeliti na dvije povezane teme:   1) Klimatska obilježja urbanih sredina i klimatsko modeliranje: proučavanje obilježja urbanih sredina u Hrvatskoj i modeliranje potencijala za primjenu zelene i plave infrastrukture kao mjere ublažavanja učinaka UHI-a uz procjenu njihove učinkovitosti. Glavna namjera ovog dijela projekta je ispitati utjecaj različitih tipova vegetacije i otvorenih vodenih površina na urbani okoliš uzimajući u obzir njegov geografski položaj, lokalna klimatska obilježja i utjecaj okoline. Nadalje, istražit će se moguće buduće promjene karakteristika urbanog klimatskog otoka uz uvažavanje regionalnih klimatskih projekcija i pretpostavljenih promjena morfologije grada te učinkovitost mjera ublažavanja UHI-a u uvjetima toplije klime.2) Klimatska varijabilnost i klimatske promjene u Hrvatskoj će biti analizirane i u kontekstu utjecaja globalnih i regionalnih procesa. Ispitat će se mogući utjecaj globalnih modova klimatske varijabilnosti na klimatske ekstreme. Očekuje se da će ovaj dio projekta omogućiti istraživanje mogućeg sinergijskog međudjelovanja klimatske varijabilnosti velike skale i urbane mikro-klime.    ]]></summary_hr><summary_en><![CDATA[Urbanization brings many benefits for the society by improving the standards of living, but on the other hand, it is also associated with unwanted environmental, social and economic consequences. One such concern is Urban Heat Island (UHI), the phenomenon characterized by considerably higher air temperatures in urban areas as compared to the surrounding suburban and rural areas. UHI is a serious environmental problem associated with multiple negative consequences (overheating of the pavement surfaces, discomfort for citizens, increased health risk, increased water demand, increased consumption of energy etc.). Climate variability and manifestations of climate change in Croatia with potential impact on urban environment are in the focus of this project. The proposed project addresses to two main topics:1.) Urban climate in Croatia and climate modelling: examination of urban climate in different Croatian cities. Modelling approach is expected to enable analyses of the urban climate as well as to estimate the potential for integrating of green and blue infrastructure in urban environment as mitigation measures for reducing UHI effects. Impacts of different types of vegetation and open water surfaces on urban micro-climate will be considered. Also, possible future changes in UHI load will be examined taking into account regional climate projections and urban morphology.     2.) Croatian climate variability and change will be analysed in the context of influence of global and regional processes. The possible impact of climate variability and climate extremes related to, for example, global modes of climate variability and heat waves will be considered as well. It is expected that results obtained in this part of the project will provide analysis of possible synergistic interaction between large-scale climate variability and urban micro-climate.]]></summary_en></project><project>
<id>6969</id><title_hr><![CDATA[Formalno obrazovanje u funkciji održivog razvoja]]></title_hr><title_en><![CDATA[Formal Education In Service of Sustainable Development]]></title_en><user_id>2588</user_id><user_firstLast_name>Bojana Ćulum</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2017-05</proposal_call><code>UIP-2017-05-2031</code><acronim><![CDATA[forOR]]></acronim><duration>03.01.2018 - 02.01.2024</duration><status>Završio</status><financ_value>144.077,24 eur</financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Pedagogija, Sociologija, </scie_field_hr><scie_field_en>Pedagogy, Sociology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Filozofski fakultet u Rijeci]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Humanities and Social Sciences]]></institution_en><team_members_id>3032, 923, 22758, 13384, 22714, 6892, 18914, </team_members_id><team_members_names><![CDATA[Nena Rončević, Siniša Kušić, Anja Gvozdanović, Branko Ančić, Nadja Čekolj, Nena Vukelić, Marija Brajdić Vuković, ]]></team_members_names><keywords_hr><![CDATA[održivi razvoj, građani održivosti, obrazovanje za održivi razvoj, kompetencije građana održivosti, obrazovanje građana održivosti]]></keywords_hr><keywords_en><![CDATA[sustainable development, sustainable citizens, sustainable citizenship, education for sustainable development, sustainable citizenship competencies]]></keywords_en><summary_hr><![CDATA[Ideja „održivosti“ prolazi kroz evolucijski put važnosti u kontekstu obrazovnih politika i praksi, a u literaturi se u posljednje dvije godine raspravlja o “građanima održivosti” i postupno se zamjenjuju poznati konstrukti ekološkog te društveno odgovornog i aktivnog građanstva. Prema UNESCO-vim smjernicama (2015, 2017), građanin održivosti razmišlja o utjecaju vlastita ponašanja na ekološki, društveni, politički i ekonomski aspekt svijeta oko sebe. Kritičan je prema vlastitom načinu življenja, a mora posjedovati kompetencije koje mu omogućuju kreativno, prilagodljivo i samoorganizirano djelovanje, razumijevanje kompleksnosti svijeta, suradnju, civilno zalaganje i djelovanje u smjeru ostvarivanja pozitivnih promjena u zajednici i društvu. Iako je obrazovanje za održivi razvoj uključeno u formalno obrazovanje, istraživanja upućuju na njegova ograničenja - postiže se pozitivan utjecaj na znanja učenika, ali ne i na njihove stavove i pro-aktivno ponašanje. O tome koliko formalno obrazovanje u Hrvatskoj doprinosi razvoju građana održivosti nema podataka pa ovaj projekt ima za cilj (I) identificirati odrednice, dominantna obilježja i zastupljenost građanstva održivosti u formalnom obrazovanju, (II) istražiti spremnost (budućih) učitelja i nastavnika za integraciju održivog razvoja u nastavu te izraditi njihovu tipologiju prema faktoru spremnosti na promjene. Rezultati istraživanja omogućiti će razvoj scenarija Obrazovanje za održivi razvoj u RH 2030. Primijenit će se multimetodološki pristup i provesti više empirijskih istraživanja o zastupljenosti i odrednicama građanstva održivosti na četiri populacije - (I) učenicima osnovnih i srednjih škola, (II) učiteljima i nastavnicima u osnovnim i srednjim školama, (III) studentima-budućim učiteljima i nastavnicima te (IV) nastavnicima u formalnom obrazovanju odraslih. Istraživanjem se doprinosi akademskoj i stručnoj raspravi u kontekstu stvaranja poticajnog okruženja za obrazovanje građana održivosti.]]></summary_hr><summary_en><![CDATA[The idea of sustainability has been going through an evolutionary path of importance in the context of educational policies and practices, while the construct of sustainable citizenship has been gradually replacing the well-known constructs of ecological and socially responsible and active citizenship. According to the UNESCO Guidelines (2015, 2017), the citizens of sustainability ponder the influence of their own behaviour regarding the ecological, social, political and economic aspects of the world. They are critical about their own way of life, and ought to possess the competencies which enable creative, adaptive and cooperative action by understanding the complexity of the world and civic engagement needed to foster positive changes. Although education for sustainable development is a part of the formal education, studies point to its limitations–it wields positive influence on students&#39; knowledge, but not on their attitudes and behaviour. There is no data on the extent to which formal education in Croatia contributes to the development of citizens of sustainability, so this project aims to (I) identify the determinants and representation of citizenship of sustainability in formal education, (II) explore competencies of (future) teachers needed to integrate sustainable development in their classes, and (III) make their typology according to their willingness to introduce changes in their teaching. Based on research results, a scenario for the Education for Sustainable Development in Croatia 2030 will be developed. A multi methodological approach with several empirical studies on the representation and the determinants of citizenship of sustainability will be implemented, targeting four populations-primary and secondary school students and teachers, student teachers, and teachers in formal adult education. The research will contribute to academic discussions on creating a stimulating environment for educating the citizens of sustainability.]]></summary_en></project><project>
<id>6971</id><title_hr><![CDATA[Jednozidne ugljikove nanocjevčice u eksperimentalnoj traumatskoj ozljedi mozga]]></title_hr><title_en><![CDATA[Single walled carbon nanotubes in experimental traumatic brain injury]]></title_en><user_id>19186</user_id><user_firstLast_name>Kristina Pilipovic</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2017-05</proposal_call><code>UIP-2017-05-9517</code><acronim><![CDATA[CarNanoTBI]]></acronim><duration>01.09.2018 - 31.08.2023</duration><status>Završio</status><financ_value>228.946,84 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Medicine]]></institution_en><team_members_id>19848, 19752, 19750, 25435, 22656, </team_members_id><team_members_names><![CDATA[Tamara Janković, Petra Dolenec, Jelena Rajič, Nika Gržeta, Anja Harej, ]]></team_members_names><keywords_hr><![CDATA[astrociti, in vitro, in vivo, jednozidne ugljikove nanocjevčice, miš, traumatska ozljeda mozga]]></keywords_hr><keywords_en><![CDATA[astrocytes, in vitro, in vivo, mouse, single walled carbon nanotubes, traumatic brain injury]]></keywords_en><summary_hr><![CDATA[Traumatska ozljeda mozga (engl. traumatic brain injury, TBI) jedan je od vodećih uzroka invaliditeta i smrti u mladih osoba širom svijeta. Astrociti, najbrojnije i najraznolikije stanice u središnjem živčanom sustavu, snažni su regulatori održavanja homeostaze staničnog okoliša, a brojni dokazi upućuju na značajnu ulogu reaktivne astrocitoze u sinaptičkoj plastičnosti i reorganizaciji neuralnih krugova nakon TBI. Također, poznato je kako disfunkcija reaktivnih astrocita negativno utječe na ishode posljedično TBI-u. Iako su mnoge pretkliničke i kliničke studije doprinijele recentnim znanjima o patofoziologiji TBI, još uvijek postoje brojne nepoznanice zbog kojih ne postoji optimalno liječenje. Jedan od obećavajućih pristupa koji bi mogao omogućiti oporavak traumatski oštećenog mozga nakon TBI je tkivni inženjering, metoda koja je usmjerena na premoštenje strukturalnih defekata u moždanom tkivu. Ugljikove nanocjevčice (engl. carbon nanotubes, CNTs) imaju brojne izuzetne osobitosti poput veličine, čvrstoće, fleksibilnosti, vodljivosti i biokompatibilnosti koje ih čine obećavajućim materijalom za brojne biomedicinske aplikacije. S obzirom na gore navedeno, hipoteze ovog projekta jesu kako kemijski funkcionalizirane jednozidne CNTs potiču preživljenje i proliferaciju te utječu na funkcije astrocita podvrgnutih in vitro TBI, a kako nakon intracerebralne aplikacije u miša s traumom mozga potpomažu procese endogenog oporavka i regeneracije. Očekujemo kako će rezultati ovog projekta omogućiti bolje razumijevanje uloga astrocita u TBI te ukazati na moguću upotrebu gore spomenutog nanomaterijala u liječenju traume mozga.]]></summary_hr><summary_en><![CDATA[Traumatic brain injury (TBI) is one of the leading causes of disabilities and death in young adults worldwide. Astrocytes, the most abundant and diverse neuroglial cells in the central nervous system, are powerful regulators of the brain environment, and extensive evidence points to the significant role of reactive astrocytosis in post-TBI synaptic plasticity and the reorganization of neural circuits. However, it is also known that the dysfunction of the reactive astrocytes can contribute negatively to the TBI outcomes.  Even though many clinical and experimental studies have contributed to our knowledge regarding the pathophysiological basis of TBI, there are still many unknowns, and that is a major reason why there is still no optimal treatment. One of the promising approaches for the repair of the traumatically injured brain is the tissue engineering, a technique that focuses on the bridging of the structural gaps in the brain tissue. Carbon nanotubes (CNTs) possess many remarkable properties, such as the size, strength, flexibility, conductivity and biocompatibility, which make them a promising material for numerous biomedical applications. Based on the above mentioned, the hypotheses of this project are that chemically functionalized single walled CNTs improve the survival, the proliferation rate and affect the functions of astrocytes subjected to in vitro TBI and that their intracerebral application following brain trauma in mice provides support for the endogenous repair and regeneration processes. We expect that the results of this project will lead to better understanding of the roles of astrocytes in TBI and reveal the potential use of the aforementioned nanomaterial in the treatment of the brain trauma. ]]></summary_en></project><project>
<id>6972</id><title_hr><![CDATA[Epigenetički biomarkeri raka prostate]]></title_hr><title_en><![CDATA[Epigenetic Biomarkers in Prostate Cancer]]></title_en><user_id>3326</user_id><user_firstLast_name>Nino Sinčić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2017-05</proposal_call><code>UIP-2017-05-8138</code><acronim><![CDATA[epiPro]]></acronim><duration>01.04.2018 - 31.03.2023</duration><status>Završio</status><financ_value>278.717,90 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Kliničke medicinske znanosti, Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Clinical sciences, Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb School of Medicine]]></institution_en><team_members_id>19967, 22587, 4711, 22582, 25378, 25176, 855381, 25371, </team_members_id><team_members_names><![CDATA[Monika Ulamec, Tomislav Kuliš, Stela Bulimbašić, Goran Štimac, Lucija Škara, Irena  Abramović, Ivan Pezelj, Dora Raos, ]]></team_members_names><keywords_hr><![CDATA[epigenetika, biomarkeri, rak prostate, metilacija DNA, miRNA, nsDNA, tekuće biopsije]]></keywords_hr><keywords_en><![CDATA[epigenetics, biomarkers, prostate cancer, DNA methylation, miRNA, cfDNA, liquid biopsies]]></keywords_en><summary_hr><![CDATA[Epigenetički poremećaji mogu se identificirati iznimno rano tijekom razvoja bolesti čovjeka. Stoga epigenetika snažno prodire u istraživanja biomarkera. Ipak, svijest o konkurentnosti epigenetičkih istraživanja sporo se razvija u hrvatskoj znanosti, što RH pozicionira na začelje europske znanosti u području. Namjera je ovog projekta podizati svijest o prednostima uvođenja epigenetičke problematike u uspostavljene istraživačke grupe, te educirati buduće mlade istraživače kao zalog budućih. Cilj je institucionalizirati grupu mladih istraživača koja će istraživati potencijalne epigenetičke biomarkere (EB) bolesti čovjeka (epiMark), odnosno identificirati EB raka prostate (RP) u okviru ovog projekta (epiPro). RP drugi je po učestalosti i treći uzrok smrti muškaraca od raka u RH. Naspram razvijenih zemalja, incidencija i mortalitet u RH stabilno rastu. Ipak, hrvatska znanost bilježi pad istraživanja RP što nas je pozicioniralo na začelje europskih zemalja gdje istraživanje EB RP predstavlja iznimno dinamično područje. Upravo EB, smatra se,  omogućit će između ostalog ranije postavljanje dijagnoze, osiguravajući i višu stopu preživljenja. Niz EB RP već je identificirano, ali ovo istraživanje prihvaća izazov najnovijeg koncepta u razvoju EB u okviru muškog reproduktivnog zdravlja – istraživanje EB sjemene tekućine, pored krvi. Hipoteza je predloženog istraživanja da se u sjemenoj tekućini, pored krvi, mogu identificirati EB RP. U okviru kliničke obrade, bit će uzeti anamnestički podaci te uzorci ejakulata i krvi pacijenata s RP i benignom hiperplazijom prostate. U sjemenoj tekućini i krvi, pirosekvenciranjem će se odrediti profili metilacije gena  na ne-staničnoj DNA, dočim qPCR-om ekspresija  miRNA, odabranih sukladno najnovijim spoznajama u literaturi. Epigenetičko i ekspresijsko profiliranje bit će provedeno i na uzorcima tumora istih pacijenata. Sveobuhvatnom statističkom analizom rezultata očekujemo identifikaciju EB RP.]]></summary_hr><summary_en><![CDATA[Epigenetic disorders can identified early during disease development. Therefore, epigenetics strongly penetrates into biomarker field. However, awareness of the competitiveness of epigenetic biomarker (EB) research is slowly developing in Croatia, which positions it at the margins of European science in the field. Intention of this project is to raise awareness of the benefits from addressing epigenetic issues into established groups and educate future young researchers as a pledge for future. The goal is to establish a new cohesive group of young researchers (epiMark) focused on investigating EB of human disease, as EB of prostate cancer (PC) within this very project (epiPro).CP is second in incidence and third cause of cancer deaths in Croatia. Contrary to developed countries, incidence and mortality in Croatia steadily rise. Nevertheless, Croatia records a fall in PC research, which has positioned us at the margins of European science where investigation of PC EB is an extremely dynamic field. Just as EB are considered, they will allow an earlier diagnosis ensuring patients a strong benefit. A line of PC EB has already been identified, but this research accepts the challenge of the latest concept in EB research within male reproductive health – a study of epigenetic BM in seminal fluid, beside blood. The hypothesis of the proposed study is that in the seminal fluid and blood, PC EB can be identified. In the frame of clinical processing of patient with PC and benign prostate hyperplasia, anamnestic data, samples of blood and seminal fluid will be taken. In seminal fluid and blood, profiles of gens DNA methylation within cfDNA will be identified by pyroseguencing, while expression of miRNA by qPCR. Genes and miRNA are selected according to recent findings. Epigenetic investigation and analysis of gene expression will be performed on patient cancer tissues as well. By comprehensible statistical analysis, we expect to identify potential CP EB from liquid biopsies.]]></summary_en></project><project>
<id>6973</id><title_hr><![CDATA[Otpornost stupova nadvožnjaka na djelovanje eksplozije ]]></title_hr><title_en><![CDATA[Blast Load Capacity of Highway Bridge Columns]]></title_en><user_id>4908</user_id><user_firstLast_name>Hrvoje Draganić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2017-05</proposal_call><code>UIP-2017-05-7041</code><acronim><![CDATA[BLAST]]></acronim><duration>01.04.2018 - 30.09.2023</duration><status>Završio</status><financ_value>197.922,89 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Građevinarstvo, Temeljne tehničke znanosti, </scie_field_hr><scie_field_en>Civil engineering, Basic engineering sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište Josipa Jurja Strossmayera u Osijeku, Građevinski i arhitektonski fakultet Osijek]]></institution_hr><institution_en><![CDATA[Josip Juraj Strossmayer University of Osijek, Faculty of Civil Engineering and Architecture Osijek]]></institution_en><team_members_id>3733, 12972, 4092, 22578, 25042, 1408, 3699, 2971, </team_members_id><team_members_names><![CDATA[Mario Jeleč, Ivan Radić, Marijana Hadzima-Nyarko, Adriana Cerovečki, Sanja Lukić, Ivan Kraus, Goran Gazić, Mario Galić, ]]></team_members_names><keywords_hr><![CDATA[stupište, eksplozije, ojačanje, numerički model, ispitivanje u stvarnom mjerilu]]></keywords_hr><keywords_en><![CDATA[column bent, blast load, strengthening, numerical model, full-scale experiment]]></keywords_en><summary_hr><![CDATA[Prometna infrastruktura postaje zanimljiv cilj terorističkih napada s obzirom da uništavanje određenih prometnih dionica ili konstrukcija, kao što su mostovi, može prouzročiti poteškoće u prometu i odsijecanje strateških točaka. Glavni cilj istraživačkog projekta je odrediti kapacitete na eksplozivna djelovanja za izgrađene mostove hrvatskih autocesta kroz određivanje najčešće korištenog tipa stupa mosta te štetu prouzročenu određenom količinom eksploziva postavljenom u automobilu smještenom ispod mosta. Prethodno istraživanje provedeno na stupovima zgrada je pokazalo da postoji veza između kapaciteta nosivosti na potresne sile i otpornosti na eksploziju. Sukladno tome, stupovi mosta će biti podijeljeni u dvije grupe, ispitani zasebno te uspoređeni s obzirom na otpornost na djelovanje eksplozija. Bit će ispitani u stvarnom mjerilu i to će biti prvo eksperimentalno istraživanje takvog tipa u svijetu. Ovo je važno budući da, bez obzira na korištene zakone skaliranja, nije moguće skalirati sve parametre koji su važni za ocjenu ponašanja stupa pri djelovanju eksplozija. Eksperimentalna istraživanja će biti provedena u suradnji s policijom koja će osigurati eksploziv i stručno osoblje za rukovanje eksplozivom. Količina eksploziva za ispitiivanje bit će određena kroz preliminarne analize na sustavima s jednim stupnjem slobode, temeljeno na pretpostavljenom stupnju ponašanja. Ovo će činiti bazu podataka mjerenih parametara uslijed djelovanja eksplozija, koja će biti korištena za kalibracije numeričkih modela. Cilj projekta je i razviti pouzdan i točan numerički model kojim će biti moguće numerički istražiti stup mosta koji nije eksperimentalno ispitan. Glavni rezultati projekta će biti: uspostavljena nova istraživačka grupa, izvršeno eksperimentalno istraživanje stupova u stvarnom mjerilu, baza otvorenog pristupa s mjerenim parametrima, točan i pouzdan numerički model stupa mosta, katalog oštećenja te prijedlog za ojačavanje i dimenzioniranje stupova mosta.]]></summary_hr><summary_en><![CDATA[Transportation infrastructure is becoming interesting target because damage or destruction of certain transportation routes or structures, as bridges, can cause disruption of traffic and cutting of strategic points. Main goal of this research project is to assess the blast load capacities of constructed bridges on Croatian highways by determining the most common type of bridge columns used and damage induced by charge detonation of certain amount of explosives by means of car deployment under the bridge. Previous research of building columns show that there is a relation between column seismic load capacity and column blast resistance. Based on this assumption, bridge columns will be separated into two groups investigated separately, and then compared for their blast resistance. Columns will be investigated in full-scale and this will be the first experimental investigation of this kind in the world. This is important because, no matter which scaling law is used, it is impossible to scale all parameters which are important for blast load assessment. Experimental investigation will be performed in cooperation with police which will provide explosives and trained personnel for explosive handling. Quantity of explosives for blast tests will be determined in preliminary single degree of freedom analysis of bridge columns based on performance levels assumed. This will make database of measured blast parameters which will be then used for numerical model calibration. Project goal is to develop reliable and accurate numerical model which will enable to numerically investigate bridge columns which are not experimentally tested. Main results of proposed project will be: establishment of a new research group, conducted experimental testing of full-scale bridge columns, open-access online database of measured blast parameters, accurate and reliable numerical model of bridge column, catalogue of sustained column damages and proposal for bridge column strengthening and design.]]></summary_en></project><project>
<id>6974</id><title_hr><![CDATA[Uloga urinarnih biomarkera u prekomjerno aktivnom mokraćnom mjehuru u djece]]></title_hr><title_en><![CDATA[Urinary biomarkers in overactive bladder in children]]></title_en><user_id>19974</user_id><user_firstLast_name>Slaven Abdović</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2017-05</proposal_call><code>UIP-2017-05-5379</code><acronim><![CDATA[pOAB]]></acronim><duration>01.01.2018 - 31.12.2022</duration><status>Završio</status><financ_value>149.885,33 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Kliničke medicinske znanosti, Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Clinical sciences, Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Klinika za dječje bolesti Zagreb]]></institution_hr><institution_en><![CDATA[Children's Hospital Zagreb]]></institution_en><team_members_id>22777, 25061, </team_members_id><team_members_names><![CDATA[Lorna Stemberger Marić, Merima Čolić, ]]></team_members_names><keywords_hr><![CDATA[Prekomjerno aktivni mokraćni mjehur, djeca, neurotrofini, NGF, urinarni biomarkeri, urodinamika]]></keywords_hr><keywords_en><![CDATA[Overactive bladder, children, neurotrophins, NGF, urinary biomarkers, urodynamics]]></keywords_en><summary_hr><![CDATA[Prekomjerno aktivni mokraćni mjehur (OAB) je najčešći funkcijski poremećaj donjeg urotrakta u djece i vodeći je uzrok intermitentne dnevne inkontinencije urina. Obligatorni simptom je hitnost, a hiperaktivnost detruzora je patognomonični urodinamski nalaz. Međutim, zbog invazivnosti urodinamike, dijagnoza se često postavlja samo na temelju simptoma. Pouzdana i neinvazivna dijagnostička metoda, kao i učinkovito liječenje, nužni su obzirom na visoku prevalenciju, značajan negativni utjecaj na kvalitetu života i nezanemarivo financijsko opterećenje. Patofiziologija bolesti temelji se na nesuspregnutim razinama neurotrofina u mjehuru, primarno NGF-a, što je potvrđeno na animalnim modelima i u kliničkim studijama. Kao učinkovito liječenje koriste se antikolinergici. Studije na odraslima pokazale su značajno više razine NGF-a u pacijenata s OAB-om koje su korelirale s težinom kliničke slike. Učinkovito liječenje dovodi do pada visokih razina urinarnog NGF-a, koje u refraktornim slučajevima perzistiraju. Refrakternost OAB-a je podržana kroničnom upalom mjehura što je potvrđeno visokom razinom urinarnih upalnih citokina. Potrebna su daljnja istraživanja kako bi se objasnila uloga urinarnih biomarkera, ne samo u patofiziologiji, već i kao učinkovite i neinvazivne dijagnostičke metode, što je osobito bitno u djece gdje se urodinamika, kao zlatni standard, većinom zaobilazi zbog nelagodnosti i nesuradnje djeteta. Ova studija je zamišljena kao prospektivna i intervencijska s ciljem ispitivanja varijabli koje značajno klinički koreliraju s produljenom primjenom antikolinergika (>6 mjeseci) i neučinkovitosti liječenja djece s OAB-om. Ispitane varijable će uključivati razine urinarnih neurotrofina i citokina, ultrazvučne biomarkere, simptome i znakove bolesti, demografske podatke i urodinamski nalaz. Sekundarni cilj je analizirati osjetljivost i specifičnost urinarnih biomarkera u dijagnostici i liječenju OAB-a u usporedbi s nalazom urodinamike i kliničkim mjerama ishoda. ]]></summary_hr><summary_en><![CDATA[Overactive bladder (OAB) is the most common bladder storage dysfunction in children and the primary cause of functional urinary incontinence. Urgency is the mandatory symptom, while detrusor overactivity is the urodynamic hallmark. Most of the time, the diagnosis is clinically based because of the invasiveness of the urodynamics. Reliable and noninvasive diagnosis, as well as effective management, are of great importance because of the high prevalence, significant negative impact on health-related quality of life, and substantial economic burden. Pathophysiology of OAB is based on uncontrollable high levels of urinary neurotrophins, primarily nerve growth factor (NGF), which was reported in animal experimental models and clinical trials. Anticholinergic therapy blocks neurotrophins pathway and is used as an effective treatment. Studies on adults have shown significantly higher NGF levels in patients with OAB which correlated to the severity of symptoms. Successful treatment resulted in significant decrease of NGF levels, while in refractory cases high urinary NGF persisted. In these patients, chronic bladder inflammation was implicated and was supported by high urinary inflammatory cytokines levels. Further research is needed to investigate the role of urinary biomarkers as a means of effective and noninvasive diagnosis, especially in children where invasive, gold standard for diagnosis of OAB, is mostly avoided. This study is planned as a single-center, prospective, single-arm trial. The aim is to investigate which variables are significantly correlated with prolonged anticholinergic treatment (>6 months) and nonresponse in children with OAB. Investigated variables will include urinary neurotrophins and inflammatory cytokines, sonographic biomarkers, symptom score, demographics, and urodynamic findings.  A secondary aim is to analyze sensitivity and specificity of urinary biomarkers in diagnosis and management of OAB compared to urodynamics and treatment outcomes.]]></summary_en></project><project>
<id>6976</id><title_hr><![CDATA[Primjena kakaove ljuske u proizvodnji čokolade i srodnih proizvoda]]></title_hr><title_en><![CDATA[Application of cocoa husk in production od chocolate and chocolate-like products]]></title_en><user_id>4578</user_id><user_firstLast_name>Đurđica Ačkar</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2017-05</proposal_call><code>UIP-2017-05-8709</code><acronim><![CDATA[COCOCHOCO]]></acronim><duration>02.01.2018 - 01.01.2023</duration><status>Završio</status><financ_value>162.756,27 eur</financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Prehrambena tehnologija, </scie_field_hr><scie_field_en>Food technology, </scie_field_en><institution_hr><![CDATA[Sveučilište Josipa Jurja Strossmayera u Osijeku, Prehrambeno-tehnološki fakultet]]></institution_hr><institution_en><![CDATA[Josip Juraj Strossmayer University of Osijek, Faculty of Food Technology]]></institution_en><team_members_id>7262, 5709, 22708, 24554, </team_members_id><team_members_names><![CDATA[Ivana  Flanjak, Antun Jozinović, Kristina  Doko, Veronika Barišić, ]]></team_members_names><keywords_hr><![CDATA[kakaova ljuska, čokolada, kakao-proizvodi, polifenoli, vlakna, sigurnost hrane]]></keywords_hr><keywords_en><![CDATA[cocoa husk, chocolate, cocoa-products, polyphenols, fibre, food safety]]></keywords_en><summary_hr><![CDATA[Opći cilj projekta je uspostaviti istraživačku grupu za istraživanja u području tehnologije čokolade. Specifični cilj: primjena kakaove ljuske u obogaćivanju čokolade i srodnih proizvoda polifenolima i vlaknima te rješavanje problema njenog zbrinjavanja i utjecaja na okoliš. U tu svrhu pratit će se sastav i udio polifenola te udio prehrambenih vlakana u proizvodima. Kakaova ljuska teže se usitnjava od kotiledona pa će se primjenom hladne plazme pokušati riješiti taj problem.  Zbog velikog sadržaja vlakana u kakaovoj ljusci može doći do porasta viskoznosti proizvoda pa će se ispitati reološka svojstva i tekstura proizvoda i pokušati naći rješenje za njihovo optimiranje. Osim nutritivno vrijednih sastojaka, kakaova ljuska je i potencijalni izvor mikrobiološke kontaminacije, zbog visokog sadržaja proteina mogući je uzrok povećanog stvaranja akrilamida (AA) i hidroksimetilfurfurala (HMF), a masti u ljusci sadrže slobodne masne kiseline koje mogu smanjiti stabilnost proizvoda. Tijekom istraživanja i ovi će se aspekti uzeti u obzir. Očekivani rezultati su uspostavljena istraživačka grupa s kapacitetom za prijavljivanje novih projekata , izrađena 2 doktorska i 3 diplomska rada, 4 znanstvena rada pripremljena za objavu i čokoladna masa, krem-namaz i pripravak za instant napitak na bazi kakaa s definiranim udjelima polifenola, vlakana, svojstvima teksture i reološkim i senzorskim svojstvima. Nadalje, bit će definiran i utjecaj kakaove ljuske na sigurnost proizvoda – s utvrđenim udjelima AA i HMF-a te aerobnih mezofilnih i nekih patogenih bakterija, te plijesni i kvasaca. Rezultati istraživanja dat će izravan doprinos u širenju primjene hladne plazme sa dekontaminacije proizvoda na modifikaciju sirovina za proizvodnju hrane; omogućit će praktičnu primjenu kakaove ljuske u poboljšanju funkcionalnih svojstava čokolade i srodnih proizvoda, te dati uvid u nastanak nepoželjnih spojeva tijekom procesiranja (AA i HMF) i mikrobiološku ispravnost proizvoda s dodanom kakaovom ljuskom.]]></summary_hr><summary_en><![CDATA[The general objective of the proposed research is to establish research group for research on chocolate production. The specific goal is an application of cocoa husk in the enrichment of chocolate and similar products with polyphenols and fibre, solving its management since it has a large environmental impact. In that manner, polyphenol content and profile, and fibre content will be monitored in the products. Cocoa husk is coarser than nibs, so cold plasma will be used in an attempt to enhance its grinding. High fibre content in the husk can increase product viscosity, so its impact on rheological properties and texture of the products will be addressed and tried to be optimised.In addition to the high content of nutritionally valuable compounds, cocoa husk can be microbiological contamination source, its high protein content can cause an increase of acrylamide (AA) and hydroxymethylfurfural (HMF) formation, and fat in the husk contain free fatty acids that can decrease product stability. These problems will be considered in the research as well.Expected results are established research group with capacity to apply new projects in chocolate technology, showing it by application of the new project to a new funding source, 2 doctoral and 3 graduate theses, 4 scientific papers and chocolate mass, cream spread and instant cocoa-based beverage with defined contents of polyphenols, fibre, texture, rheology and sensory properties. Influence of the cocoa husk on food safety will be revealed as well – with revealed AA and HMF content, aerobic mesophyllic bacteria, several pathogenic bacteria and moulds and yeast content.The results will contribute to cold plasma application broadening to modification of food raw materials, it will aid practical application of cocoa husk to increase functional properties of chocolate and like products, and give insight into a synthesis of unwanted compounds during production and microbiological compliance of the products.]]></summary_en></project><project>
<id>6977</id><title_hr><![CDATA[Uloga Notch signalnog puta u patogenezi jetrene fibroze]]></title_hr><title_en><![CDATA[The Role of Notch Signalling Pathway in Pathogenesis of Hepatic Fibrosis]]></title_en><user_id>2631</user_id><user_firstLast_name>Tomislav Kelava</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2017-05</proposal_call><code>UIP-2017-05-1965</code><acronim><![CDATA[NOFIBRO]]></acronim><duration>16.07.2018 - 01.05.2024</duration><status>Završio</status><financ_value>185.811,93 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, Kliničke medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, Clinical sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb School of Medicine]]></institution_en><team_members_id>3133, 4149, </team_members_id><team_members_names><![CDATA[Petra Turčić, Anna Mrzljak, ]]></team_members_names><keywords_hr><![CDATA[fibroza jetre, Notch, alkoholna bolest jetre, praćenje sudbine stanica, transgenični model]]></keywords_hr><keywords_en><![CDATA[hepatic fibrosis, Notch, alcohol liver disease, fate mapping, transgenic mice]]></keywords_en><summary_hr><![CDATA[Osnovni cilj istraživanja je definirati ulogu Notch signalnog puta u patogenezi jetrene fibroze. U studiji ćemo koristiti animalni transgenični model u kojem se transgeničnim miševima Notch signalni put može selektivno potaknuti ili inhibirati u stanicama koje izražavaju alfaSMA primjenom tamoksifena .  Jetrena fibroza će biti inducirana primjenom CCL4 ili hranjenjem s DDC. U pojedinim pokusioma ćemo Notch inhibirati primjenom SAHM1 koji je specifičniji za NOtch od inhibitora korištenih u dosadašnjim studijama. Također, planiramo prikupljati I ljudske uzorke jetrenog tkiva cirotičnih I necirotičnih jetara I odrediti izražaj gena I proteina povezanih s Notch signalnim putovima, Iz uzoraka krvi, izdvojit će se DNA I određivati povezanost između odabranih Notch jednonukleotidnih genskih polimorfizama I jetrene fibroze tako što ćemo usporediti zastupljenoist polimorfizama u pacijenata sa cirozom jetre nastale zbog završnog stadija alkoholne bolesti  jetre koja zahtijeva liječenje transplantacijom sa zastupljenošću u kontrolnoj skupini.]]></summary_hr><summary_en><![CDATA[The main goal of project proposal is to define the role of Notch signaling in pathogenesis of hepatic fibrosis. To achieve this we will use animal transgenic mice model  in which Notch signalling can be activated or inhibited by tamoxifen injection selectively in alphaSMA expressing cells. To these mice hepatic fibrosis will be induced by CCL4 application and DDC feeding. In some experiments we will inhibit Notch pathway pharmaceutically by application of SAHM1 which is Notch specific in comparison with inhibitors used in previous studies.  We will also collect human samples from cirrhotic and noncirrhotic liver tissue and assess expression of Notch related genes and proteins. From blood samples DNA will be extracted to assess association between the selected Notch pathway single nucleotide polymorphisms and hepatic fibrosis by comparing their prevalence in general population with one in patients with end-stage liver disease due to alcoholic cirrhosis which require liver transplantation.]]></summary_en></project><project>
<id>6982</id><title_hr><![CDATA[Erozija i degradacija tala Hrvatske]]></title_hr><title_en><![CDATA[Soil erosion and degradation in Croatia]]></title_en><user_id>20011</user_id><user_firstLast_name>Igor Bogunović Bogunović</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2017-05</proposal_call><code>UIP-2017-05-7834</code><acronim><![CDATA[SEDCRO]]></acronim><duration>01.04.2018 - 31.03.2023</duration><status>Završio</status><financ_value>263.401,69 eur</financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Poljoprivreda, </scie_field_hr><scie_field_en>Agriculture, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Agronomski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Agriculture]]></institution_en><team_members_id>22749, 19017, 20377, 25053, 25711, 855969, </team_members_id><team_members_names><![CDATA[Paulo Pereira, Aleksandra Perčin, Ivana Šestak, Leon Josip Telak, Iva  Hrelja, Ivan Dugan, ]]></team_members_names><keywords_hr><![CDATA[erozija tla vodom, degradacija tala, vinogradi, klimatske promjene, voćnjaci]]></keywords_hr><keywords_en><![CDATA[soil water erosion, soil degradation, vineyards, climate changes, orchards]]></keywords_en><summary_hr><![CDATA[Degradacija tla je glavni okolišni problem u svijetu i ključno je da takvi procesi budu ublaženi. Potreba da se smanji utjecaj poljoprivrednih aktivnosti na okoliš i kontrolira degradacija strukture tala je jedan od glavnih ciljeva gospodarenja tlima. Različite strategije su razvijene radi smanjenja najvažnijeg degradacijskog problema – erozije tla. Međutim, poljoprivreda je još uvijek izvor najviše sedimenata u površinskim otjecajnim vodama. Danas, mnoštvo razloga pokreće neprihvatljivo gospodarenje tlima na poljoprivrednim tlima RH. Usprkos važnosti teme istraživanja o degradaciji tala na poljoprivrednim tlima u RH nedostaju. Mehanizmi, procesi, proporcije i kontrola erozije tla bili su istraživani u „Zapadnim“ državama više od stoljeća, ali je nadopuna potrebna radi prenošenja novih saznanja i rasprave o novim izazovima. U RH takva istraživanja nedostaju što otvara mnoga pitanja tijekom svakodnevnih klimatskih ekstrema. Klimatske promjene povećavaju broj olujnih kiša. Takve oluje su uzrok netolerantnih erozijskih nanosa s razarajućim posljedicama po okoliš. Istraživanje erozije i degradacije tla na tlima u RH mogu pružiti detaljan uvid za razumijevanje procesa degradacije tala. Trenutna tema istraživanja može otkriti najugroženija tla i najlošije načine korištenja istih. Glavni faktori koji određuju gubitak tla erozijom i površinskim otjecanjem biti će ocjenjeni.Ovaj projekt predlaže kompletni pregled tla, korištenja zemljišta u drugačijim klimatskim uvjetima u Hrvatskoj koji se bave problemom erozije tla vodom. Baza podataka iz 5-godišnjeg istraživanja (s više od 40 lokacija) biti će jedan od najkompletnijih aktualnih baza za proučavanje utjecaja uzročnih čimbenika na eroziju tla vodom. ]]></summary_hr><summary_en><![CDATA[Soil degradation is a major environmental problem worldwide and is crucial that such processes must be mitigated. The need to reduce the environmental impact of agricultural activities and to control soil structure degradation is one of the main aims of land management. Strategies have been developed to reduce the most important degradation problem- soil erosion. However, agriculture is still the source of most sediments in surface runoff waters. Nowadays, complex of reasons are driving forces for unsustainable soil management practices in Croatian agricultural land. Despite the relevance of the topic there is lack of research on soil degradation on Croatian agricultural soils. The mechanisms, processes, rates and control of soil erosion have been scientifically studied in Western countries, but an update was needed to convey new findings and discuss new challenges. In Croatia, such research is missing which especially open the new dilemma during every-day climatic extremes. Climate changes increase a numbers of high rainfall intensity events. Such events triggered intolerant soil erosion rates with devastating consequences to environment.Research of soil erosion and degradation on Croatian soils can provide deep insight for understanding the processes of soil degradation. Present subject can help to discover most endanger soils and unsustainable land use practices. This project will quantify water and soil losses in Croatian agricultural soils under high intensity rainfall simulation on the soils under several land use and management strategies. The main factors that determine soil losses and runoff will be assessed.This project proposed an overview of soils, land use, and climatic conditions in Croatia that deal with the problem of soil water erosion. Dataset derived from 5 years research (from more than 40 locations) will be one of the most complete and up to-date databases for studying the effect of triggering factors on soil water erosion. ]]></summary_en></project><project>
<id>6984</id><title_hr><![CDATA[ALTERNATIVNA VEZIVA ZA BETON: razumijevanje mikrostrukture za predviđanje trajnosti]]></title_hr><title_en><![CDATA[ALTERNATIVE BINDERS FOR CONCRETE: understanding microstructure to predict durability]]></title_en><user_id>3398</user_id><user_firstLast_name>Marijana Serdar</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2017-05</proposal_call><code>UIP-2017-05-4767</code><acronim><![CDATA[ABC]]></acronim><duration>01.04.2019 - 31.07.2024</duration><status>Završio</status><financ_value>285.020,83 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Građevinarstvo, Temeljne tehničke znanosti, </scie_field_hr><scie_field_en>Civil engineering, Basic engineering sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Građevinski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Civil Engineering]]></institution_en><team_members_id>1276, 17806, 855345, 856242, 856244, 856247, 863810, 863808, 863809, 866632, 17771, 867584, </team_members_id><team_members_names><![CDATA[Ivan Gabrijel, Martina Pezer, Ivana Vladić Kancir, Matea Flegar, Kiran Ram Porikam Poil Poil, Antonino Runci Runci, Alma-Dina Bašić, Josipa Skočibušić Pejić, Marko Rukavina, Olivera Bukvić, Vanja Gilja, Valentina Mustapić, ]]></team_members_names><keywords_hr><![CDATA[alternativna veziva, održivost, mikrostruktura, trajnost, napredni instrumenti]]></keywords_hr><keywords_en><![CDATA[alternative binders, sustainability, microstructure, durability, advance techniques]]></keywords_en><summary_hr><![CDATA[Ukupna proizvodnja cementa u 2015. godini iznosila je 4,6 milijarde tona, što iznosi oko 626 kg cementa po stanovniku, količina veća od ukupne potrošnje hrane po stanovniku. Ako građevinska industrija nastavi s &#39;&#39;poslovanjem kao i obično&#39;&#39;, s obzirom na očekivani brzi rast populacije i predviđenu povećanu proizvodnju, u 2050. godini samo proizvodnja cementa će doprinijeti oko 24% ukupne globalne emisije CO2. Kako bi se istovremeno zadovoljila potreba ljudi za urbanizacijom i europski ciljevi zaštite prirodnih resursa i smanjenja emisija, postoji snažna motivacija za razvoj održivih građevinskih rješenja s manjim utjecajem na okoliš, sukladnih sedmom osnovnom zahtjevu za građevinske radove - održivom korištenju prirodnih resursa.Alternativni veziva za beton (ABC) predstavljaju novu generaciju građevinskih materijala, temeljenih na industrijskom otpadu i dosada neiskorištenim materijalima, koji su održiva i ekonomska alternativa klasičnom Portland cementu. Da bi se postigla gotovo potpuna zamjena cementa, od najveće je važnosti koristiti temeljnije pristupe istraživanju alternativnih veziva, omogućujući razumijevanje materijala na više razina (nano-mikro-makro). Istodobno, kako bi se osigurala upotreba ovih alternativnih materijala u praksi, potrebno je koristiti napredne analitičke instrumentalne metode i pouzdane modele za procjenu životnog vijeka kao odgovor na pitanja koja se tiču dugoročne trajnosti ABC u agresivnom okolišu.Ciljevi projekta su: osnivanje istraživačke skupine kao centra izvrsnosti za istraživanja, razumijevanje i korelaciju mikrostrukture i trajnosti alternativnih veziva za beton; osposobljavanje za samostalno korištenje naprednih analitičkih instrumentalnih metoda, koje pruža regionalna mreža instrumentarija; te obučavanje od strane međunarodnih centara znanja i izvrsnosti u specifičnom istraživačkom području. Nakon projekta ABC istraživačka skupina će biti održiva kroz konkurentno sudjelovanje u europskom istraživačkom prostoru.]]></summary_hr><summary_en><![CDATA[In 2015, the total mass of cement produced was 4,6 billion tonnes, which is equivalent to about 626 kg of cement/per capita, a value higher than the amount of human food consumption. If construction industry continues with “business as usual”, considering the expected rapid population growth and predicted production increase, in 2050 cement industry alone will contribute to 24% of total global CO2 emission. To meet the people’s need for urbanisation and at the same time satisfy European goals for protection of natural resources and lowering emissions, there is a strong motivation to develop more sustainable construction solutions with a lower environmental impact and in line with 7th basic requirement for construction works - sustainable use of natural resources.Alternative binders for concrete (ABC) present a new generation of construction materials, based on industrial waste and abundant materials, that are sustainable and economic alternative to ordinary Portland cement. To be able to reach high or total cement replacement, it is of paramount importance to use more fundamental approaches to research of alternative binders, enabling understanding across several scales (nano-micro-macro). At the same time, to secure their use in practice, it is necessary to use advance analytical tools and reliable service life models to answer the questions concerning long term durability of ABC in aggressive environments.The aim of the project is to establish research group as a centre of expertise for multiscale research, understanding and correlation of microstructure and durability of alternative binders for concrete, capable to autonomously use advanced analytical techniques provided by regional instrumentation network and trained by international centres of knowledge and excellence in the specific research field. After the project ABC research group will continue to be sustainable through competitive participation in European Research Area.]]></summary_en></project><project>
<id>6985</id><title_hr><![CDATA[Hrvatske filozofkinje u europskom kontekstu]]></title_hr><title_en><![CDATA[Croatian women philosophers in the European context]]></title_en><user_id>3152</user_id><user_firstLast_name>Luka Boršić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2017-05</proposal_call><code>UIP-2017-05-1763</code><acronim><![CDATA[CroWomPhil]]></acronim><duration>01.01.2018 - 31.12.2022</duration><status>Završio</status><financ_value>102.200,52 eur</financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Filozofija, </scie_field_hr><scie_field_en>Philosophy, </scie_field_en><institution_hr><![CDATA[Institut za filozofiju]]></institution_hr><institution_en><![CDATA[Institute for Philosophy in Zagreb]]></institution_en><team_members_id>2634, 17758, 25011, 3877, </team_members_id><team_members_names><![CDATA[Ivana Skuhala Karasman, Ana Maskalan, Matko Gjurašin, Ankica Čakardić, ]]></team_members_names><keywords_hr><![CDATA[filozofkinje, Hrvatska, povijest, filozofija, feminizam]]></keywords_hr><keywords_en><![CDATA[women philosophers, Croatia, history, philosophy, feminism]]></keywords_en><summary_hr><![CDATA[U projektu Hrvatske filozofkinje u europskom kontekstu imamo dva cilja:1. Prvi je cilj analitički proučiti hrvatske filozofkinje od počeka do naših dana i potom napisati monografsku povijest filozofije koja bi bila posvećena isključivo hrvatskim ženama u filozofiji u Hrvatskoj ili vezano uz Hrvatsku. Ovim proučavanjem hrvatskih filozofkinja i publikacijama o njima želimo ispuniti prazninu u sustavnom proučavanju našeg intelektualnog i društvenog nasljeđa budući da dosad u Hrvatskoj nema ni jedne povijesti filozofije, udžbenika ili kompendija u kojem bi se analizirale i sustavno prezentirale filozofske misli filozofkinja u Hrvatskoj ili vezanim za Hrvatsku. Rezultati našeg projekta bili bi sustavno i cjelovito istražene sljedeće filozofkinje: Mare Gundulić Gučetić, Helene Druskowitz, Elza Kučera, Ivana Rossi, Elly Ebenspanger, Marija Brida, Heda Festini, Blaženka Despot, Jasenka Kodrnja i Gordana Bosanac.2. Drugi je cilj uspostaviti Centar za istraživanje žena u filozofiji (CIŽUF) koji bismo osnovali pri Institutu za filozofiju u Zagrebu po uzoru na slične takve centre u Europi što dopušta Statut i Strategija Instituta za filozofiju. Osim proučavanja života i djela hrvatskih filozofkinja, CIŽUF bi istraživao recepcije stranih filozofkinja u Hrvatskoj i hrvatskih filozofkinja izvan Hrvatske, povijest feminizma, feminističke metateorije te žene kao predmeta filozofskog bavljenja. CIŽUF bi poticao suradnju s pojedincima i institucijama iz svih znanstvenih područja koji bi iskazali interes za interdisciplinarno istraživanje vezano uz predmete bavljenja CIŽUF. Oblici aktivnosti CIŽUF bi bili sljedeći: sastavljanje knjižnice, recepcija svjetskih filozofkinja u Hrvatskoj i ostalih tema kojima se CIŽUF bavi; organiziranje znanstvenih skupova, okruglih stolova, radionica, ljetnih škola, javnih predavanja, izložaba i ostali rad na popularizaciji i diseminaciji i razmjeni znanja; održavanje i izrada mrežne stranice; različita tiskana izdanja, prijevodi, zbornici itd.]]></summary_hr><summary_en><![CDATA[Our project &#39;&#39;Croatian women philosophers&#39;&#39; contains two main goals:1. The first goal is an analytic examination of Croatian women philosophers from the beginning to our day and then to write the monographic history of philosophy that would be devoted exclusively to Croatian women in philosophy in Croatia or in relation to Croatia. The results of our project would offer a complete and systematic research of Croatian women philosophers especially with respect to their ties and mutual influences of the wider European context since a systematic reserach into Croatian women philosophers has not yet been done in Croatia.. The focus of our study will be put on the following women philosophers: Mare Gundulić Gučetić, Helene (von) Druskowitz, Elza Kučera, Ivana Rossi, Elly Ebenspanger, Marija Brida, Heda Festini, Blaženka Despot, Jasenka Kodrnja i Gordana Bosanac.The second goal is foundation of a “Research center for women in philosophy (RCWP)” modelled on similar centres in Europe. The host institution of RCWP would be Institute of Philosophy in Zagreb and RCWP would be dedicated to the historical-philosophical study of women philosophers in Croatia and the close parts of the European environment. Areas of research of RCWP would be: Croatian women philosophers, non-Croatian women philosophers who lived or live in Croatia and/or are otherwise connected with Croatia, reception of non-Croatian women philosophers in Croatia, reception of Croatian women philosophers outside Croatia, the history and development of feminism(s) in Croatia, feminist metatheory, and woman as an object of philosophical studies. Activities of RCWP would be: creating a library, organization of scientific conferences, roundtables, workshops, summer schools, public lectures, exhibitions and other activities aiming at popularization and dissemination and exchange of knowledge; creating and maintaining a bilingual Croatian-English web page (Women in philosophy). various publications, translations etc.]]></summary_en></project><project>
<id>6986</id><title_hr><![CDATA[Dobrobit, pripadnost i društvena pravednost]]></title_hr><title_en><![CDATA[Well-being, affiliation and social justice]]></title_en><user_id>3291</user_id><user_firstLast_name>Nebojša Zelič</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2017-05</proposal_call><code>UIP-2017-05-3462</code><acronim><![CDATA[Dobrobit/WellBeing]]></acronim><duration>01.01.2018 - 31.12.2022</duration><status>Završio</status><financ_value>75.205,52 eur</financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Filozofija, </scie_field_hr><scie_field_en>Philosophy, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Filozofski fakultet u Rijeci]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Humanities and Social Sciences]]></institution_en><team_members_id>22778, 896, 19830, 26568, </team_members_id><team_members_names><![CDATA[Ana Gavran Miloš, Ana Petek, Ivan Cerovac, Tamara Crnko, ]]></team_members_names><keywords_hr><![CDATA[Dobrobit, pravednost, pripadnost, jednakost, teorija sposobnosti]]></keywords_hr><keywords_en><![CDATA[Well-being, justice, affiliation, equality, capability approach]]></keywords_en><summary_hr><![CDATA[Projekt Dobrobit, pripadnost i društvena pravednost ima četiri specifična cilja istraživanja:(1) Prvo, cilj je istražiti dosadašnju raspravu o teorijama koje prihvaćaju vrijednosni pluralizam ali ujedno smatraju da modeli socijalne pravednosti mogu i trebaju biti usmjereni ka postizanju određenih funkcija koje čine život dobrim. Sukladno tome, cilj nam je pokazati da postoji jedna koncepcija dobrog života, a to je dobrobit određena kao zadovoljenje minimuma sposobnosti kako ih određuje Nussbaum, koja osigurava ljudsko dostojanstvo.(2) Drugo, istraživanje u sljedećem koraku ima za cilj ispitati važan aspekt određenja ljudskog dostojanstva, a to je pripadnost zajednici. S obzirom na to, cilj nam je pokazati da je za dobrobit ljudskog života važno promicati pripadnost zajednici.(3) Treći cilj istraživanja je pokazati na koji način naše razumijevanje TS i promicanje pripadnosti može pružiti puno bolji okvir socijalne pravednosti u čije središte ulaze pojmovi socijalne (a ne samo distributivne) nejednakosti, detektirajući na koje bi se funkcije više trebala usmjeriti pažnja u razvijanju javnih politika koje streme ka socijalnoj jednakosti.(4) Cilj empirijskog dijela istraživanja je opisati iskustva članova neprivilegiranih ciljanih skupina hrvatskih javnih politika s obzirom na relevatnost pojedinih sposobnosti, na specifične okolnosti razvoja pojedinih sposobnosti, utjecaj ekonomskog, društvenog i političkog konteksta na  ostvarivanje pojedinih sposobnosti, te efekte različitih državnih mjera na sposobnosti i dobrobit pojedine grupe.]]></summary_hr><summary_en><![CDATA[Project Well-being, affiliation and social justice has four specific research objectives:(1) First, the aim is to explore the current discussion on the theories that accept value pluralism, but also believe that social justice models may and should be directed towards achieving certain functions that make good life. Accordingly, our aim is to show that there is a concept of good life, and that it is determined by the capabilities which ensure human dignity.(2) The second aim is to examine an important aspect of human dignity. Here we want to show that human dignity and well-being as such are established upon the specific capability for affiliation. Unlike other capability theorist we want precisely to claim that it is particularly important to promote community affiliation in order to promote well-being specific for human life.(3) In the  next step of the study, the aim is to show how our understanding of the CA and promotion of affiliation can provide insights for the state and policy makers on the development of public policies that strive for social equality, by identifying those capabilities and functionings that should be focused on in order to promote well-being.(4) The aim of empirical part of the project is to describe the experiences of the underprivileged target groups of Croatian public policies about the relevance of certain capabilities; the specific circumstances of the development of different capabilites; the influence of the economic, social and political context on the achievement of different capabilities; and the effects of different state measures on the capabilities and well-being of the specific groups.]]></summary_en></project><project>
<id>6990</id><title_hr><![CDATA[Dinamika u sustavima u kojima postoji mikro-segregacija]]></title_hr><title_en><![CDATA[Dynamics in micro-segregated systems]]></title_en><user_id>5591</user_id><user_firstLast_name>Bernarda Lovrinčević</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2017-05</proposal_call><code>UIP-2017-05-1863</code><acronim><![CDATA[DINAMIS]]></acronim><duration>10.09.2018 - 09.09.2023</duration><status>Završio</status><financ_value>119.249,23 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, </scie_field_hr><scie_field_en>Physics, </scie_field_en><institution_hr><![CDATA[Sveučilište u Splitu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Split, Faculty of Science]]></institution_en><team_members_id>5569, 855333, </team_members_id><team_members_names><![CDATA[Martina Požar, Ivo Jukić, ]]></team_members_names><keywords_hr><![CDATA[dinamika, mikro-segregacija, simulacije, vodene otopine, dinamička teorija funkcionala gustoće]]></keywords_hr><keywords_en><![CDATA[dynamics, micro-segregation, simulation, aqueous mixtures, dynamical density functional theory]]></keywords_en><summary_hr><![CDATA[Kompleksne mješavine, kao što su vodene otopine, imaju vrlo specifičnu strukturu koja proizlazi iz specifičnog tipa interakcija, kao što su hidrofobne i hidrofilne interakcije. To rezultira mikro-segregacijom molekula koje u nekim sustavima dovode do stvaranja novih objekata, kao što su micele ili domene. Međutim, informacije o dinamici tih novoformiranih struktura prilično su rijetke, posebno u području simulacija molekularne dinamike, gdje rezultati snažno ovise o računalnim resursima. Ovaj projekt ima za cilj poboljšati razumijevanje životnog vijeka novoformiranih objekata i njihovu kinetiku, što je problem koji se nalazi u srži biofizike, gdje se objekti kao što su membrane konstruiraju od lipidnih molekula u vodenom okolišu. Teorijsko istraživanje dinamike tekućih tvari razvilo se od ranih dana fizike tekućina (1970). Dok je primjena na jednostavne tekućine potvrdila valjanost raznih teorijskih pristupa, primjena na vodene otopine, naročito ne-elektrolita, bila je vrlo rijetka. Smatra se da su simulacije molekularne dinamike bolji način istraživanja tih sustava. U tom kontekstu za teoretičara, poželjno je razviti i testirati alate statističke fizike tekućina za ove otopine. Posebno, poželjno je razumjeti zašto te metode nisu primjenjive na te otopine na isti način kao i na  jednostavne tekućine. Ovaj problem nas navodi da se zapitamo što čini ključnu razliku između jednostavnih i složenih tekućina. Proteklih godina smo proučavali ovaj problem upravo sa statičkog stajališta. Osnovna razlika je da su složene otopine mikro-segregirane, s domenama u rasponu veličina od 1 do 5 nm. To se događa zbog međusobnih konkurentskih interakcija vodikovih veza, koje omogućuju samo-udruživanje molekula putem malih domena.]]></summary_hr><summary_en><![CDATA[Complex mixtures, such as aqueous mixtures, have a very particular structure that stems from the specific type of interactions, namely the hydrophobic and the hydrophilic interaction. This results in micro-segregation of molecules which in some systems leads to the creation of new objects, such as micelles or domains. However, the information about the dynamics of these newly formed structures are rather scarce, especially in the field of molecular dynamics simulations, where the results strongly depend on the computational resources. This projects aims at understanding the lifetime of newly formed objects and their kinetics, which is a problem that lies at the heart of biophysics and material science, where objects such as membranes are being constructed from lipid molecules in water milieu. The theoretical investigation of the dynamics of liquid matter have been developed since the early days of the physics of the liquid state (1970). While the application to simple liquids has confirmed the validity of the various theoretical developments, the extension to aqueous mixtures, and in particular non-electrolytes, have been very scarce. Molecular Dynamics simulations are thought to be a better way to explore these systems. In this context, and for a theoretician, it is desirable to develop and test the tools of statistical physics of liquids for these mixtures. And more particularly, it is desirable to understand why these methods do not apply to these mixtures in the same manner they apply for simple liquids. This problem sends us to ask what makes the essential difference between simple and complex liquids. And it turns out that we have precisely studied this problem in the past years, from static point of view. The principal difference is that complex mixtures are micro-segregated, with species domains in the 1-5 nm range. This is due to competing hydrogen bond interactions, which tend to favour self-association of species over small domains.]]></summary_en></project><project>
<id>6991</id><title_hr><![CDATA[Primjena inovativnih tehnika ekstrakcije bioaktivnih komponenti iz nusproizvoda biljnoga podrijetla]]></title_hr><title_en><![CDATA[Application of innovative techniques of the extraction of bioactive components from by-products of plant origin]]></title_en><user_id>3836</user_id><user_firstLast_name>Stela Jokić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2017-05</proposal_call><code>UIP-2017-05-9909</code><acronim><![CDATA[ByProExtract]]></acronim><duration>01.01.2018 - 31.12.2022</duration><status>Završio</status><financ_value>213.379,62 eur</financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Prehrambena tehnologija, </scie_field_hr><scie_field_en>Food technology, </scie_field_en><institution_hr><![CDATA[Sveučilište Josipa Jurja Strossmayera u Osijeku, Prehrambeno-tehnološki fakultet]]></institution_hr><institution_en><![CDATA[Josip Juraj Strossmayer University of Osijek, Faculty of Food Technology]]></institution_en><team_members_id>7395, 19191, 19195, 22686, 24555, 25722, 862787, </team_members_id><team_members_names><![CDATA[Ines Banjari, KRUNOSLAV ALADIĆ, Nika Pavlović, Senka Vidovic, Marija Banožić, Silvija Šafranko, Jelena Vladic Vladic, ]]></team_members_names><keywords_hr><![CDATA[ekstrakcija, zelene tehnologije, bioaktivne komponente, nusproizvod, optimizacija]]></keywords_hr><keywords_en><![CDATA[extraction, green technologies, bioactive components, byproduct, optimization]]></keywords_en><summary_hr><![CDATA[Cilj svake proizvodnje (industrije) je dobivanje kvalitetnog proizvoda, uz što bolje iskorištenje sirovine. Tijekom prerade sirovine nastaje određena količina nusproizvoda koji nužno ne moraju biti otpad i “problem” nego visokovrijedna sirovina za razvoj novih proizvoda. Kakao ljuska, otpad iz proizvodnje duhana i kore citrusa su nusproizvodi koji nastaju u velikim količinama i  koji su još uvijek nedovoljno istraženi i iskorišteni unatoč sadržaju značajnih korisnih tvari. Cilj ovog projekta je proizvodnja ekstrakata iz navedenih nusprozvoda primjenom šest inovativnih zelenih ekstrakcijskih tehnika: superkritične fluidne ekstrakcije, ekstrakcije vodom u supkritičnom stanju, ekstrakcije potpomognute mikrovalovima, ekstrakcije potpomognute ultrazvukom, ekstrakcije potpomognute hladnom plazmom i ekstrakcije eutektičkim otapalima. U određivanju ciljanih bioaktivnih komponenti iz odabranih nusproizvoda primjenit će se visokosofisticirane kromatografske tehnike. Zbog velike raznolikosti bioaktivnih komponenti iz odabranih nusproizvoda, za svaku primijenjenu tehniku ekstrakcije definirat će se optimalni procesni parametri primjenom metode odzivnih površina. Ekstrakti s najvećim biološkim potencijalom će se postupkom sušenja raspršivanjem prevesti u praškasti oblik s potencijalnom komercijalnom primjenom.Rezultati istraživanja doprinjeti će rješenju problema velikih količina organskog otpada koji predstavlja ogroman ekološki i financijski teret u svim segmentima procesne industrije. Naglasak projekta je na potencijalnoj komercijalnoj valorizaciji rezultata istraživanja i transferu dobivenih rezultata u industriju, kao i na jačanju veze akademske zajednice s industrijom s ciljem ekonomskog razvoja i boljitka cijelog društva.]]></summary_hr><summary_en><![CDATA[All industries aim to obtain a quality product and to utilise raw materials as efficiently as possible in the production process. During the processing of raw materials, a certain amount of by-products is produced, which does not necessarily have to be “waste”, but a by-product or high value raw material for development of new products. Cocoa shells, tobacco waste, and citrus peels, are by-products produced in large quantities which are usually underutilized or considered as waste, in spite of the fact that they contain different classes of useful components. The aim of this project is to obtain extracts rich in bioactive components from selected by-products using six innovative green extraction techniques: supercritical fluid extraction (SFE), subcritical water extraction (SWE), microwave-assisted extraction (MAE), ultrasound-assisted extraction (UAE), cold atmospheric plasma assisted extraction (CAPAE), and extraction using deep eutectic solvents (DES). Determination and isolation of bioactive components from selected by-products will be performed using highly sophisticated chromatographic techniques. Due to great diversity of bioactive components from diverse material, optimal extraction conditions will be defined for each applied technique by using response surface methodology (RSM). Extracts with the highest biological potential will be dried by using spray drying technology in order to produce plant powders with potential commercial application. The results of the research will contribute to solving the problem of large quantities of organic waste, which represents an enormous ecological and financial burden for all aspects of the process industry. Special emphasis in the project will be put on the possible commercial valorisation of the research results and on the transfer of those results to the application level, as well as on strengthening the relationship between the academic community and the industry.]]></summary_en></project><project>
<id>6992</id><title_hr><![CDATA[Dinamičnost kategorija specijaliziranoga znanja]]></title_hr><title_en><![CDATA[Dynamicity of Specialized Knowledge Categories]]></title_en><user_id>2897</user_id><user_firstLast_name>Ana Ostroški Anić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2017-05</proposal_call><code>UIP-2017-05-7169</code><acronim><![CDATA[DIKA]]></acronim><duration>10.03.2018 - 09.03.2023</duration><status>Završio</status><financ_value>118.848,48 eur</financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Filologija, </scie_field_hr><scie_field_en>Philology, </scie_field_en><institution_hr><![CDATA[Institut za hrvatski jezik]]></institution_hr><institution_en><![CDATA[Institute of Croatian Language]]></institution_en><team_members_id>1143, 2892, 22580, 7422, 22698, 25084, </team_members_id><team_members_names><![CDATA[Maja Lončar, Ivana Brač, Ivanka Rajh, Martina Bajcic, Larisa Grčić Simeunović, Martina Pavić, ]]></team_members_names><keywords_hr><![CDATA[terminologija, semantički okviri, semantika okvira, specijalizirano znanje, specijalizirana komunikacija]]></keywords_hr><keywords_en><![CDATA[terminology, semantic frames, Frame Semantics, specialized knowledge, specialized communication]]></keywords_en><summary_hr><![CDATA[Glavni je cilj projekta Dinamičnost kategorija specijaliziranoga znanja uspostaviti istraživačku grupu koja će provoditi međunarodno relevantna istraživanja iz područja terminologije. U okviru provodit će se istraživanja pojmovne i jezične razine terminoloških jedinica i kategorija specijaliziranoga znanja, zatim sintaktičko – semantička istraživanja sintagmatskih sveza naziva te diskursna istraživanja komunikacijske uloge naziva u strukovnim područjima zrakoplovstva, prava, marketinga i krša. Istraživanja će se provoditi primjenjujući teorijske postavke i spoznaje semantike okvira i terminologije okvira te oslanjajući se na komunikacijsku terminološku teoriju i sociokognitivni terminološki pristup. Kontrastivnim analizama prijevodnih ekvivalenata u hrvatskom, engleskom, njemačkom i francuskom jeziku doprinijet će se teorijskim istraživanjima stručnoga prevođenja. Primijenjeni su rezultati projekta englesko – hrvatski paralelni korpus tekstova iz domene zračnog prometa te terminološka baza okvira AirFrame u kojoj će nazivlje iz područja zrakoplovstva biti definirano u semantičkim okvirima s odgovarajućim elementima okvira, pojmovnim odnosima, figurativnim i frazeološkim terminološkim jedinicama. Zrakoplovni nazivi, definicije i jezični kontekst na hrvatskom jeziku pratit će ekvivalenti naziva i konteksta na trima jezicima: engleskom, francuskom i njemačkom. Na taj će se način izgraditi deskriptivna terminološka baza usmjerena prevoditeljskim potrebama, ali i postaviti model za izgradnju slične višedomenske i višejezične baze znanja hrvatskoga jezika.]]></summary_hr><summary_en><![CDATA[The main objective of the project Dynamicity of Specialized Knowledge Categories is establishing a research group that will work on internationally competitive research topics in the field of terminology. Theoretical research of terminological units and specialized knowledge categories at conceptual and linguistic levels, syntactic and semantic analyses of the syntagmatic term relations, as well as theoretical research of the communicative functions of terms in discourse based on examples from the domains of aviation, law, marketing and karstology. The research follows the theoretical framework of Frame Semantics and Frame-based Terminology, taking into account relevant findings from the Communicative Theory of Terminology and the Sociocognitive terminology theory. Contrastive analyses of the translation equivalents in Croatian, English, German and French will contribute to the development of theoretical research in the field of specialized translation. The project’s applied results include an English – Croatian parallel corpus in the domain of air traffic, and the terminological database of semantic frames AirFrame, in which the aviation terminology is defined in semantic frames including semantic elements, conceptual relations, and figurative and phraseological terminological units. English, French and German equivalents of terms and linguistic contexts are added to the Croatian part of the aviation terminology. A translator-oriented descriptive terminological database created following this methodology will serve as a model for the creation of a similar multidomain and multilingual knowledge base of the Croatian language.]]></summary_en></project><project>
<id>6993</id><title_hr><![CDATA[Uloga bradikinina u ishemiji mozga i mrežnice u mišjim modelima dijabetesa]]></title_hr><title_en><![CDATA[The role of bradykinin in brain and retinal ischemia in diabetic murine models]]></title_en><user_id>6226</user_id><user_firstLast_name>Marina Radmilović (Dobrivojević)</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2017-05</proposal_call><code>UIP-2017-05-8082</code><acronim><![CDATA[BRADISCHEMIA]]></acronim><duration>01.09.2018 - 31.03.2024</duration><status>Završio</status><financ_value>261.463,93 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb School of Medicine]]></institution_en><team_members_id>19920, 22669, 22672, 22761, 5583, 22595, 25188, 25294, 865161, 25363, </team_members_id><team_members_names><![CDATA[Anton Glasnović, Grosche Antje, Dirk Wiedermann, Marin Radmilović, Zoran Vatavuk, Sandra Grgić, Helena Justić, Anja Barić, Marta Pongrac, Martina Ratko, ]]></team_members_names><keywords_hr><![CDATA[dijabetes, ishemija, bradikinin, moždani udar, dijabetička retinopatija]]></keywords_hr><keywords_en><![CDATA[diabetes, ischemia, bradykinin, stroke, diabetic retinopathy]]></keywords_en><summary_hr><![CDATA[Dijabetes je kronična bolest koja obuhvaća metaboličke poremećaje obilježene povišenom razinom glukoze u krvi kao posljedicom nedovoljne proizvodnje inzulina, rezistencije na djelovanje inzulina ili obaju mehanizama. Trenutno pola milijarde ljudi diljem svijeta ima dijabetes. Tijekom trajanja dijabetesa, trećina oboljelih razvije ishemijski moždani udar,  trećina razvije dijabetičku retinopatiju, a obje navedene komplikacije dovode do ozbiljnog invaliditeta s neizmjernim socioekonomskim utjecajem. S patofiziološkog gledišta, i dijabetička retinopatija i moždani udar karakterizirani su ishemijom. Bradikinin je među prvim upalnim čimbenicima koji se javljaju s nastupom ishemije. Bradikinin povećava permeabilnost krvno-moždane/-žilnične barijere, inducirajući nastanak edema. Budući da aktivacija njegovih receptora pridonosi nastanku edema i oštećenju tkiva modulacijom post-ishemijskog upalnog odgovora, potraga za inhibitorima koji bi mogli smanjiti te štetne učinke postala je važan cilj. Ipak, uloga bradikininskih receptora nije jednostrana, budući da su zabilježeni i razni povoljni učinci njihove aktivacije, poput prevencije odumiranja endotelnih stanica, redukcije glutamatne neurotoksičnosti, te preživljenja i migracije glija stanica. Ova dovojaka uloga bradikininskih receptora poticaj je za naše istraživanje, kojim ćemo istražiti ulogu bradikininskog receptora tipa 2 u dvama specifičnim komplikacijama koje se razvijaju u tijeku dijabetesa: dijabetičkoj retinopatiji i moždanom udaru. Korištenjem uspostavljenih modaliteta snimanja magnetskom rezonancijom, omogućit će nam longitudinalno praćenje razvoja ishemijske moždane ozljede. Također planiramo unutar već uspostavljenog laboratorija razviti s novu platformu za multimodalno pretkliničko istraživanje bolesti mrežnice, prvu platformu takve vrste u Republici Hrvatskoj, a koja bi otvorila mogućnosti novim i sveobuhvatnijim pretkliničkim istraživanjima ekperimentalnih terapija i učinkovitijoj translaciji prema klinici.]]></summary_hr><summary_en><![CDATA[Diabetes mellitus is a chronic disease that comprises metabolic conditions characterized by elevated blood glucose levels resulting from either inadequate insulin production, resistance to insulin action, or both. Currently, half a billion people are affected by diabetes worldwide. During the course of the disease, one-third of diabetic patients develop ischemic stroke, one third develop diabetic retinopathy, both leading to severe disabilities with immense socioeconomic impact. Pathophysiologicaly, both diabetic retinopathy and stroke are characterized by ischemia. Bradykinin is one of the first inflammatory factors released during the ischemia. Bradykinin increases the blood-brain/retinal barrier permeability, inducing edema formation. Since activation of bradykinin receptors contributes to brain edema and tissue damage modulating the post-ischemic inflammatory response, the search for inhibitors that could diminish these detrimental effects has become an important issue. However, the role of bradykinin receptors is not so unambiguous, since different beneficial effects of their activation were also shown in preventing endothelial cell death, lowering glutamate neurotoxicity, and enhancing glial cell survival and migration. This ambiguous role of the bradykinin receptors is what prompts our research, which will be achieved through the research of the role of bradykinin in two distinct complications that occur in the course of diabetes: diabetic retinopathy and ischemic stroke. By using magnetic resonance imaging modalities, we aim to perform a longitudinal study of the progression of cerebral ischemia. Within the established imaging facility, we plan to set up a completely new platform for multimodal preclinical research of retinal diseases, which would be the first platform of its kind in Croatia and would open up possibilities for novel more comprehensive preclinical evaluation of experimental therapies with a more efficient preclinical to clinical translation.]]></summary_en></project><project>
<id>6994</id><title_hr><![CDATA[Razvoj modela za povećanje efikasnosti izrade i funkcionalnosti grafičke ambalaže]]></title_hr><title_en><![CDATA[Development of the model for production efficiency increase and functionality of packaging]]></title_en><user_id>19215</user_id><user_firstLast_name>Tomislav Cigula</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2017-05</proposal_call><code>UIP-2017-05-4081</code><acronim><![CDATA[MEGA]]></acronim><duration>15.02.2018 - 14.02.2023</duration><status>Završio</status><financ_value>133.638,60 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Grafička tehnologija, </scie_field_hr><scie_field_en>Graphics technology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Grafički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Graphic Arts]]></institution_en><team_members_id>22684, 3559, 5900, 19216, 25166, 26526, 865526, </team_members_id><team_members_names><![CDATA[Ante Poljičak, Tamara Tomašegović, Marija Prša, Davor Donevski, Tomislav Hudika, Petar Branislav Jelušić, Marina Vukoje, ]]></team_members_names><keywords_hr><![CDATA[grafička ambalaža, GCR, digitalni vodeni žig, funkcionalni premaz, matematičko modeliranje]]></keywords_hr><keywords_en><![CDATA[packaging, GCR, digital watermark, functional coatings, mathematical modeling]]></keywords_en><summary_hr><![CDATA[Grafička tehnologija je polje iz grane tehničkih znanosti s visokim stupnjem primjenjivosti u sustavima koji se naslanjaju na tehnološke napretke u području računarskih znanosti i inženjerstva i znanosti o materijalima. Specifičnost ovog istraživačkog područja jest upravo dvosmjerna veza između digitalnog okruženja koje se odnosi na manipulaciju i obradu slikovnih informacija i „realnog“ okruženja u kojem se navedene informacije reproduciraju koristeći različite materijale. Ovo istraživanje se provodi s ciljem razvoja modela za povećanje efikasnosti izrade i funkcionalnosti grafičke ambalaže. Navedeni cilj postići će se kroz provođenje grupa aktivnosti koje bismo mogli podijeliti u četiri osnovne skupine:-	Razvoj i evaluacija metode za zamjenu kromatskih boja akromatskom komponentom(GCR)-	Razvoj metode za implementaciju digitalnog vodenog žiga kao sredstva zaštite grafičke reprodukcije-	Karakterizacije grafičkih materijala i razvoj funkcionalnih premaza te analizom njihovih utjecaja karakteristika na višebojnu reprodukciju-	Razvoj i ocjena matematičkog modela koji će povezati utjecaj elemenata modulacije slikovne informacije i karakteristika materijala te oplemenjivanja otisaka na mehanička svojstva i vizualnu percepciju reprodukcijeOčekuje se da će rezultati ovog istraživanja doprinijeti povećanju konkurentnosti proizvodnje ambalažnog proizvoda, uz istovremeno povećanje funkcionalnosti kroz implementaciju zaštitnih elemenata u slikovni zapis te oplemenjivanje materijala poboljšavajući mu mehanička svojstva te vizualnu percepciju.Dodatni aspekt projektnog prijedloga je razvoj istraživačkog kapaciteta kroz uvođenje mladih znanstvenika u istraživački proces te njihovo usavršavanje kroz doktorski studij, pripremu publikacija te prezentacijom rezultata i diskusiji sa stručnjacima iz područja na znanstvenim skupovima.]]></summary_hr><summary_en><![CDATA[Graphic technology is a part of technical sciences which implements research advances in the various fields including computer science ad material sciences. This fact leads to a specific approach to the research as one must always have in mind the two way communication between image data manipulation in the digital and materials interaction in the printing process and product finishing.  The aim of this research proposal is to develop the model for production efficiency increase and functionality of packaging. This goal will be achieved by conducting of activities which could be divided in four main groups:- development and evaluation of the grey colour replacement (GCR) method- development of the method for implementing digital watermark as a mean to enable graphic reproduction protection- characterization of graphic materials and development of functional coatings and their impact on the multicolour graphic reproduction- development and evaluation of the mathematical model which will make connection between influence of the digital image modulation and material&#39;s characteristics and prints refining on it&#39;s mechanical properties and visual perception.It is expected that results of this research will contribute to the increase of the packaging production competitiveness, but simultaneously increase packaging functionality by implementing protecting elements in the image and material refinement to increase it&#39;s mechanical properties and visual perception.In addition, conducting of this project proposal will enable development of the research capacity by introducing young researchers into the research processes and specialization through finishing the PhD study, preparing research papers and presenting them at scientific conferences where they will be involved in discussions with researchers in the field.]]></summary_en></project><project>
<id>7000</id><title_hr><![CDATA[Matematička analiza i numeričke metode za višefazne sustave vođene difuzijom]]></title_hr><title_en><![CDATA[Mathematical analysis and numerical methods for diffusion driven multiphase systems]]></title_en><user_id>5872</user_id><user_firstLast_name>Mario Bukal</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2017-05</proposal_call><code>UIP-2017-05-7249</code><acronim><![CDATA[MANDphy]]></acronim><duration>01.03.2018 - 31.08.2023</duration><status>Završio</status><financ_value>118.058,27 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Matematika, </scie_field_hr><scie_field_en>Mathematics, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id>3179, 72, 865249, </team_members_id><team_members_names><![CDATA[Anja Vrbaški, Marko Erceg, Matija Livaić, ]]></team_members_names><keywords_hr><![CDATA[višefazni sustavi, nelinearna difuzija, unakrsna difuzija, homogenizacije, numeričke metode koje čuvaju strukturu]]></keywords_hr><keywords_en><![CDATA[multiphase systems, nonlinear diffusion, cross-diffusion, homogenization, structure preserving numerical schemes]]></keywords_en><summary_hr><![CDATA[Projekt se bavi teorijskim aspektima i numeričkom analizom parcijalnih diferencijalnih jednadžbi koje opisuju sustave s više faza, a javljuju se u fizici, biologiji i geologiji. Točnije, bavit ćemo se parcijalnim diferencijalnim jednadžbama koje opisuju: (i) dinamiku granice između dviju odvojenih faza (npr. granica zrak / tekućina ili tekućina / tekućina u tankim viskoznim fluidima, granica u sustavima spinova itd.) i (ii ) dinamiku gustoće ili volumnih udjela faza (npr. nemješive tekućine u poroznom mediju, viševrsni modeli u biologiji, kemiji itd.). U svim tim jednadžbama &#39;&#39;pokretačka sila&#39;&#39; dinamike proizlazi iz difuzijske strukture jednadžbe: degenerirana difuzija u obliku prostornih derivacija četvrtog reda (i) i sustav nelinearnih difuzijskih i unakrsnih difuzijskih jednadžbi (ii). Motivacije za proučavanje takvih sustava proizlaze iz brojnih i raznovrsnih primjena, što mi ocrtavamo kroz četiri scenarija: (1) fluktuacija granice u  sustavima spinova, (2) dinamika tankog viskoznog fluida s toplinskim efektima, (3) sanacija nafte u spremnicima ugljikovodika i (4) viševrsni biološki naliči za obradu otpadnih voda. Naši glavni ciljevi su analiza postojanja fizikalno relevantnih slabih rješenja, analiza njihovih kvalitativnih svojstava (dugoročno ponašanje, sebi-sličnost rješenja, eksplozija ili prekid itd.), izvod homogeniziranih (makroskopskih) modela za modele s višeskalnom prirodom poput modela  bioloških naliča za obradu otpadnih voda, i konačno, konstrukcija pouzdanih numeričkih metoda, koje čuvaju strukturu jednadžbi i u stanju su dohvatiti kvalitativna opažanja. Uspješna provedba ovog projekta doprinijet će najnovijim saznanjima u području istraživanja i bit će dodana vrijednost zajednici primijenjene matematike u Hrvatskoj.]]></summary_hr><summary_en><![CDATA[The project deals with theoretical aspects and numerical analysis of partial differential equations, which describe systems with multiple phases arising in physics, biology and geology. More precisely, we are interested in partial differential equations describing: (i) dynamics of the interface between two separated phases (e.g. air/liquid or liquid/liquid interface in thin viscous films, interface in spin systems, etc.), and (ii) dynamics of densities or volume fractions of system phases (e.g. immiscible fluid flows in porous medium, multispecies models in biology, chemistry, etc.). In all these equations the &#39;&#39;driving force&#39;&#39; of the dynamics emanates from the diffusion structure of the equation: degenerate diffusion in terms of fourth-order spatial derivatives (i), and systems of nonlinear diffusion and cross-diffusion equations (ii). Motivations for studying such systems arise from numerous and versatile applications and we render it through four application scenarios: (1) interface fluctuations in spin systems, (2) dynamics of thin viscous fluids with thermal effects, (3) oil recovery in hydrocarbon reservoirs, and (4) multispecies biofilms for wastewater treatment. Our main goals are to undertake the existence analysis of physically relevant weak solutions, analysis of their qualitative properties (long-time behaviour, self-similarities, blow-up or rupture, etc.), derivation of homogenized (macroscopic) models for models of multiscale nature like the biofilm model for wastewater treatment, and finally, to construct reliable structure preserving numerical schemes, which are able to capture qualitative observations. Successful implementation of this project will contribute to the state of the art in the research field and will be an added value to the Croatian applied mathematics community.]]></summary_en></project><project>
<id>7002</id><title_hr><![CDATA[Konsocijacija drvenastih vrsta i poljoprivrednih kultura kao inovativni pristup u agroekosustavima]]></title_hr><title_en><![CDATA[Intercropping of wood species and agricultural crops as an innovative approach in agroecosystems]]></title_en><user_id>20421</user_id><user_firstLast_name>Vladimir Ivezić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2017-05</proposal_call><code>UIP-2017-05-7103</code><acronim><![CDATA[AGROINOVA]]></acronim><duration>01.02.2018 - 31.01.2023</duration><status>Završio</status><financ_value>198.279,41 eur</financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Poljoprivreda, </scie_field_hr><scie_field_en>Agriculture, </scie_field_en><institution_hr><![CDATA[Sveučilište Josipa Jurja Strossmayera u Osijeku, Fakultet agrobiotehničkih znanosti Osijek]]></institution_hr><institution_en><![CDATA[Josip Juraj Strossmayer University of Osijek, Faculty of Agrobiotechnical Sciences in Osijek]]></institution_en><team_members_id>20380, 19239, 18940, 22803, 20436, 22802, 28689, 858405, </team_members_id><team_members_names><![CDATA[Josipa Puškarić Puškarić, Brigita  Popović, Miro Stošić, Jurica Jović, Vladimir  Zebec, jelena ilić, Helena Žalac, Ante Bubalo, ]]></team_members_names><keywords_hr><![CDATA[konsocijacija, orah, poljoprivredni usjevi, mikroklima, biološka raznolikost, konzervacija tla]]></keywords_hr><keywords_en><![CDATA[Intercopping, walnut, agricultural crops, microclimate, biodiversity, soil conservation]]></keywords_en><summary_hr><![CDATA[Konsocijacija ili kombinacija kultura podrazumijeva uzgoj više kultura na istoj površini u isto vrijeme. Glavne prednosti konsocijacije su: bolja iskoristivost proizvodne površine, pozitivan utjecaj na plodnost tla, raznolikost proizvodnje u jednoj vegetaciji, zaštita od pojave bolesti, štetnika i korova, bolja iskoristivost hraniva i vode u tlu te povećana biološka raznolikost. U konsocijacijama koje podrazumijevaju uzgoj u nasadima oraha poželjno je odabrati nasade s cijepljenim orasima zbog činjenice da orah luči juglon koji može imati toksičan efekt na nicanje drugih biljaka. Naime, u nasadima oraha s cijepljenim stablima lučenje juglona nije tako intenzivno i djelovanje juglona u prvih 15 godina u takvim nasadima nema značajno toksičan učinak. Isto tako, preporučljivo je unošenje organske tvari jer se time potiče mikrobiološka aktivnost koja pospješuje razgradnju juglona. Drugi važan čimbenik u ovakvim konsocijacijama jest odabir poljoprivrednih kultura koje su otporne na nisku pH vrijednost jer orah eksudatima zakiseljuje tlo.Cilj projektnog prijedloga je istražiti utjecaj međuodnosa cijepljenih oraha i poljoprivrednih kultura na mikroklimu te time na bioraznolikost u tlu (mikrobiološku aktivnost u tlu te strukture zajednice nematoda), konzervaciju tla i štetne organizme poput uzročnika biljnih bolesti. Pokus će biti proveden kroz pet godina, na dva lokaliteta u dvije županije od kojih će se svaki sastojati od tri parcele – kontrolna parcela sa usijanim poljoprivrednim kulturama bez oraha, parcela s nasadom oraha gdje će između redova biti usijane poljoprivredne kulture te trajni nasad oraha bez ratarskih kultura. Na osnovu dobivenih rezultata biti će kreiran kompjuterski model za predviđanje utjecaja mikroklime na istraživane parametre u projektnom prijedlogu. Iako su takvi modeli dostupni u svijetu u Republici Hrvatskoj ovo će biti prvi model takvog tipa koji će biti primjenjiv za agroekološke uvijete u široj regiji, odnosno područje dunavskog sliva.  ]]></summary_hr><summary_en><![CDATA[Intercropping or a combination of plant species involves more species on the same parcel at the same time. The main benefits of the intercropping are: better use of the production area, positive influence on soil, diversity of production, protection against plant disease, pests and weeds, better use of nutrients and water in soil as well as increased biodiversity. In intercropping systems with walnut it is desirable to choose orchards with grafted plants since the walnut tree secretes juglone that may have a toxic effect on the germination of other plants. In the orchards of walnuts with grafted trees, the secretion of juglone is not so intense and the activity of the juglone in the first 15 years in such intercropping systems has no significant toxic effect. Also, it is advisable to introduce organic matter as it promotes microbiological activity that decompose juglone. Another important factor in such systems is the selection of plants resistant to low-pH, since the walnuts can acidify soil.The aim of the proposed project is to investigate the interaction between grafted walnuts and agricultural crops to microclimate and consequently to soil biodiversity (microbiological activity in soil and nematode community structure), soil conservation and occurrence of plant diseases.The field trial will be conducted during five years, at two locations in two Counties, each field trial will consist of three parcels - control plot of agricultural crops without walnuts, walnut orchards with intercropped agricultural crops and a permanent walnut orchard without intercropped agricultural crops. Based on the obtained results, a computer model will be created for predicting the influence of microclimate on the investigated parameters in the project proposal. Although such models are available worldwide in the Republic of Croatia, this will be the first model of such type that will be applicable for agroecological conditions in the wider region, mainly the Danube Basin area.]]></summary_en></project><project>
<id>7003</id><title_hr><![CDATA[Utjecaj specifične površine oplošja čestice na hidrogeološka svojstva prapora i na njima razvijenih tala istočne Hrvatske]]></title_hr><title_en><![CDATA[Impact of specific surface area on hydrogeological properties of loess deposits and loess-derived soils in eastern Croatia]]></title_en><user_id>5920</user_id><user_firstLast_name>Kosta Urumović</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2017-05</proposal_call><code>UIP-2017-05-9435</code><acronim><![CDATA[ISSAH]]></acronim><duration>01.02.2018 - 31.01.2023</duration><status>Prekinut</status><financ_value>183.366,89 eur</financ_value><scie_area_hr>Tehničke znanosti, Biotehničke znanosti, Prirodne znanosti, </scie_area_hr><scie_area_en>Technological sciences, Biotechnical sciences, Natural sciences, </scie_area_en><scie_field_hr>Rudarstvo, nafta i geološko inženjerstvo, Geologija, Građevinarstvo, Poljoprivreda, </scie_field_hr><scie_field_en>Mining, petroleum and geological engineering, Geology, Civil engineering, Agriculture, </scie_field_en><institution_hr><![CDATA[Hrvatski geološki institut]]></institution_hr><institution_en><![CDATA[Croatian Geological Survey]]></institution_en><team_members_id>22781, 19631, 22782, 3405, 19512, 22798, 22785, 25274, </team_members_id><team_members_names><![CDATA[Vedran Rubinić, Tamara Dadić, Staša Borović, Jasmina Lukač Reberski, Jasmina Martinčević Lazar, Ivica Pavičić Pavičić, Marina Bubalo Kovačić, Marco Pola, ]]></team_members_names><keywords_hr><![CDATA[prapor, specifična površina oplošja čestice, hidrogeološki parametri, pedološka svojstva , zaštita podzemnih voda]]></keywords_hr><keywords_en><![CDATA[loess, specific surface area, hydrogeological properties, pedological properties, groundwater protection]]></keywords_en><summary_hr><![CDATA[Znanstveni i praktični interes o praporima je izrazito polidisciplinaran. Pri tome su interesantne teme osnovni i akcesorni granulometrijski i petrografski sastav, geometrijska svojstva pora povezanih s veličinom šupljina i specifičnom površinom oplošja krutine), sadržaj organskih tvari i fosilnih ostataka, sadržaj vlage, protočnost i zadržavanje vode, fizikalna i kemijska interakcija sadržane vode i krutine, okolišna hidrografska obilježja, geotehnička svojstva, lokalni i regionalni morfološki položaj i obilježja podinskih naslaga. Strateški značaj prapornih naslaga se za Republiku Hrvatsku prvenstveno temelji na poljoprivrednom i građevinskom korištenju i na zaštiti podzemnih voda. Specifična površina oplošja čestica tla je osnovno fizikalno svojstvo nevezanih i slabo vezanih tvorevina. Veličina specifične površine i petrološka obilježja sadržanih čestica u tlu presudno upravljaju kemijskim i fizikalnim procesima u tlu, a posljedica su kemijskog i mineralnog sastava tla. Isto tako, specifična površina uvjetuje hidrogeološka, geomehanička i pedološka svojstva tala koja imaju ulogu zaštite podzemnih voda, prikladnost za građevinske radove i poljoprivredne podloge. Ovaj je projekt zamišljen kao interdisciplinarno istraživanje utjecaja toga osnovnog fizikalnog parametra tla na mjerilu uzorka na hidrogeološke, geomehaničke, pedološke i poljoprivredne uvjete. Ovim će se projektom oformiti istraživačku grupu mladih hrvatskih znanstvenika iz različitih polja znanosti i usmjeriti ju u istraživanje sitnozrnastih klastičnih naslaga te proizvesti podlogu budućih interdisciplinarnih istraživanja u svrhu zaštite podzemnih voda i efikasnog korištenja zemljišta.Istraživanja bi se provodila na prostoru Baranje, Srijema i Istočne Slavonije gdje prapori i praporu slične tvorevine prekrivaju velike površine. Znanstveno utemeljeno poznavanje njihovih svojstava na konkretnim lokacijama i njihova regionalizacija važna su podloga za aktualni napredak i dugoročni razvitak ovih krajeva.]]></summary_hr><summary_en><![CDATA[Scientific and practical interest in loess deposits is extremely polidisciplinary. Interesting topics are the basic granulometric and petrographic composition, geometric properties of pores associated with size of pores and specific surface area of the solid, organic matter, moisture, permeability and water retention, physical and chemical interaction of the contained water and the solids, environmental hydrographic characteristics, geomechanical properties, local and regional morphology and the characteristics of bedrock. The strategic importance of loess deposits for the Republic of Croatia is based on agricultural and construction use and on the protection of groundwater. Specific surface area of soil particles is the basic physical property of non-cohesive and poorly-cohesive materials. Specific surface area and petrological characteristics of the soil particles are crucial to the chemical and physical processes in the soil, being the result of the chemical and mineral composition of soil. Hydrogeological, geomechanical and pedological properties of soils that have crucial role in groundwater protection, soil suitability for construction works and agricultural substrates are conditioned by the specific surface area. This project is conceived as an interdisciplinary study of the influence of this fundamental physical parameter on hydrogeological, geomechanical, pedological and agricultural conditions. The project will form a research group of young Croatian scientists from different fields of science and focus it on studying fine-grained deposits. It will produce the basis for future interdisciplinary researches for the purpose of groundwater protection and efficient land use. Researches will be conducted in Baranja, Srijem and Eastern Slavonia where loess covers large areas. Scientifically based knowledge of loess properties at specific locations and their regionalization is an important basis for the current progress and long-term development of these regions.]]></summary_en></project><project>
<id>7007</id><title_hr><![CDATA[Ispitivanje i modeliranje mehaničkog ponašanja bioosušenog otpada kao preduvjet energetske oporabe]]></title_hr><title_en><![CDATA[Testing and modelling of mechanical behavior of biodryed waste as a Waste-to-Energy prerequisite]]></title_en><user_id>742</user_id><user_firstLast_name>Igor Petrović</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>UIP</proposal_type><proposal_call>2017-05</proposal_call><code>UIP-2017-05-5157</code><acronim><![CDATA[WtE]]></acronim><duration>01.01.2018 - 30.06.2023</duration><status>Završio</status><financ_value>123.293,85 eur</financ_value><scie_area_hr>Tehničke znanosti, Prirodne znanosti, </scie_area_hr><scie_area_en>Technological sciences, Natural sciences, </scie_area_en><scie_field_hr>Građevinarstvo, Kemijsko inženjerstvo, Temeljne tehničke znanosti, </scie_field_hr><scie_field_en>Civil engineering, Chemical engineering, Basic engineering sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Geotehnički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Geotechnical Engineering]]></institution_en><team_members_id>7418, 25255, 25881, 2527, 858370, </team_members_id><team_members_names><![CDATA[Linke Li, Nikola Kaniški, Nikola Hrnčić, Ivana Melnjak, Dino Bosilj, ]]></team_members_names><keywords_hr><![CDATA[bioosušeni MBO otpadni materijal, projektiranje bioreaktorskog odlagalita, otpad u energiju, mehaničko ponašanje otpada, konstitutivni modeli]]></keywords_hr><keywords_en><![CDATA[biodryed MBT waste material, bioractor landfill design, waste-to-energy, mechanical behavior of waste, constitutive modeling]]></keywords_en><summary_hr><![CDATA[Predloženi projekt orijentiran je na eksperimentalno ispitivanje i numeričko modeliranje mehaničkog ponašanja bioosušenog otpada. Biosušenje je varijacija aerobne razgradnje koja se primjenjuje za parcijalnu stabilizaciju komunalnog otpada. Nakon biosušenja otpad se upućuje u daljnju obradu gdje se izdvaja organski bogata sitnozrnata frakcija pogodna za odlaganje na bioreaktorsko odlagalište. Jednom odložena, ova se frakcija ponovno podvrgava postupku vlaženja, s ciljem energetske oporabe nastalog bioplina za proizvodnju toplinske i/ili električne energije. U RH postoje dva MBO postrojenja s izlaznim proizvodom pogodnim za odlaganje na bioreaktorsko odlagalište.U RH trenutno ne postoje bioreaktorska odlagališta iako Pravilnik o načinima i uvjetima odlaganja otpada (NN 114/15) prepoznaje bioreaktorska odlagališta. Kao jedan od razloga svakako se može istaknuti nedovoljan broj eksperimentalnih podataka o geotehničkim parametrima razmatranog otpada. Drugi razlog je nedostatak prikladnog numeričkog modela za ovu vrstu otpada. Uslijed ovih nedostataka projektiranje bioreaktorskih odlagališta nije moguće.Stoga je glavni cilj predloženog istraživanja razviti, na temelju utvrđenih eksperimentalnih podataka, prikladan konstitutivni model za opisivanje 3-D stanja naprezanja i deformacija sitnozrnate frakcije bioosušenog otpada. Razvijeni model mogao bi se koristiti za potrebe projektiranja bioreaktorskih odlagališta. Model bi svoju primjenu mogao naći ne samo u RH već i u drugim zemljama regije kod kojih MBO tehnologija tek treba biti implementirana.Rezultati ovog projekta omogućit će racionalniji pristup u projektiranju odlagališta otpada, kao i nadopunu Strategije gospodarenja otpadom Republike Hrvatske. Osim toga, rezultati pokusa će pružiti sveobuhvatan skup dobro kontroliranih, novih generičkih mjerila za računalnu validaciju različitih aspekata modeliranja MBO otpada te doprinijeti unaprjeđenju prediktivne snage modela za potrebe projektiranja odlagališta otpada.]]></summary_hr><summary_en><![CDATA[The proposed project is focused on the experimental investigation and numerical modelling of the biodryed waste. Biodrying is a variation of aerobic process which is used for partial stabilization of municipal waste. After biodrying process the waste is submitted for further processing to extract organically rich fine-grained fraction suitable for disposal on a bioreactor landfill. Once disposed, the waste is once again moisturized in order to energetically reuse produced biogas through generation of thermal and/or electrical energy. There are two operating MBT plants in Republic of Croatia whose final product is suitable for disposal on bioreactor landfill.There are no bioreactor landfills built on Croatian territory yet, although the Ordinance on the methods and conditions for the landfill of waste (OG 114/15; R Croatia) recognizes bioreactor landfills.The insufficient experimental data about geotechnical parameters of biodryed waste can be emphasized as one of the reasons. The second reason is the lack of the appropriate numerical model. Due to the mentioned obstacles, the proper design of bioreactor landfill is not feasible. The main goal of the proposal is to develop an appropriate constitutive model for general 3-D stress paths for the fine-grained fraction of biodryed waste. The proposed model can then be used as a design tool for bioreactor landfills. Since a lot of countries in the Danube area should implement waste treatment technologies, the usefulness of the proposed model is not strictly limited to Croatia.The obtained results will allow more rational landfill design and retrofit waste management strategies in Croatia.The experimental results will provide a comprehensive set of well controlled, novel generic benchmarks to computationally validate various modelling aspects of the biodryed MBT waste material and contribute towards its improved predictive power of proposed model for the landfill design purposes. ]]></summary_en></project><project>
<id>7090</id><title_hr><![CDATA[Istraživanje shizofrenije kroz ekspresiju netopivih proteina]]></title_hr><title_en><![CDATA[Characterization of Aggregated Proteins in Neuropsychiatric Disorders, including Drosophila Models]]></title_en><user_id>22771</user_id><user_firstLast_name>Nicholas Bradshaw</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2018-01</proposal_call><code>IP-2018-01-9424</code><acronim><![CDATA[CandidIskren]]></acronim><duration>08.11.2018 - 07.07.2023</duration><status>Završio</status><financ_value>132.722,81 eur</financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Biotehnologija, </scie_field_hr><scie_field_en>Biotechnology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Fakultet biotehnologije i razvoja lijekova]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Biotechnology and Drug Development]]></institution_en><team_members_id>23696, 23637, 69, 29297, 29295, 29346, 864878, 864880, 855734, 855733, 28659, </team_members_id><team_members_names><![CDATA[Gordana Rubeša, Aristea Pavešić Radonja, Rozi Andretić Waldowski, Bobana Samardžija Samardžija, Maja Odorčić, Giovanna Dashi, Mihaela Bergman, Simone Ruhije Bertoša, Tina Fartek, Anja Hart, Beti Zaharija, ]]></team_members_names><keywords_hr><![CDATA[Shizofrenija, Mentalna bolest, Agregiranje proteina, Drosophila, Neuroznanost]]></keywords_hr><keywords_en><![CDATA[Schizophrenia, Mental illness, Protein Aggregation, Drosophila, Neuroscience]]></keywords_en><summary_hr><![CDATA[Schizofrenija, bipolarni poremećaj i teška depresija su devastirajuće mentalne bolesti s jako kompliciranom genetskom pozadinom. U cilju izbjegavanja složenosti genetike, predlažemo istraživanje izravno na proteinima uključenim u staničnu patologiju. Inspiraciju smo dobili zahvaljujući spoznajama neurodegenerativnih bolesti, kao što su Alzheimerova i Parkinsonova bolest, u kojima specifični proteini formiraju netopive krivo smotane agregate u mozgu. Radna hipoteza je da poremećena proteostaza može također biti razlog kroničnim mentalnim bolestima. Rezultati istraživanja upućuju na pet proteina koji potencijalno formiraju netopive agregate u mozgu dijela pacijenata s teškim mentalnim bolestima. To su: CRMP1. DISC1, dysbindin-1, NPAS3 and TRIOBP-1. Do danas nije poznato da li ovi proteini agregiraju zajedno ili imaju kumulativni efekt u istom pacijentu.Predloženi projekt ima za cilj integrativni pristup istraživanju agregacije ovih pet proteina. Biti će određena regija neophodna za agregaciju i iskorištena za sintezu mutiranih formi koje imaju ili nemaju sposobnost stvaranja agregata. Potom će divlji tip i mutant protein biti analizirani u cilju određivanja posljedice agregacije, bilo zasebno ili u kombinaciji. Istraživat će se na neuronima sličnim staničnim kulturama da se odrede posljedice agregata na razvoj, i također na transgenoj vinskoj mušici - Drosophila u cilju testiranja utjecaja na ponašanje.Eksperimente koje predlažemo, u budućnosti mogu poslužiti za analizu proteinskih agregata mentalnih bolesti u kompleksnijim trensgenim modelima. Također će omogućiti važne spoznaje o mogućoj uporabi agregata kao dijagnostičkih biomarkera i meta budućim terapeutskim intervencijama.]]></summary_hr><summary_en><![CDATA[Schizophrenia, bipolar disorder and major depression are devastating mental illnesses with a highly complicated genetic background. In order to circumvent this, we have proposed studying directly proteins involved in their cellular pathology. Specifically, we have taken inspiration from neurodegenerative conditions, such as Alzheimer&#39;s disease or Parkinson&#39;s disease, in which specific proteins form insoluble misfolded aggregates in the brain. We therefore hypothesised that disrupted proteostasis may also be a component of chronic mental illness. Data now exists implicating five proteins as potentially forming insoluble aggregates in the brains of subsets of patients with major mental illness: CRMP1, DISC1, dysbindin-1, NPAS3 and TRIOBP-1. To date however, it is not clear whether these proteins aggregate together or have cumulative effects on the same patients.The project proposed here therefore aims to take an integrative approach to studying the aggregation of these five proteins. The regions of these proteins required for aggregation will be determined and used to design mutant forms of them which either have or lack the ability to form aggregates. These wild-type and mutant proteins will then be investigated, in order to determine the consequences of aggregation of the proteins, both individually and in combination. This will be performed both in neuronal-like cell culture systems, in order to determine the consequences of aggregation on development, and also in transgenic Drosophila fruit flies in order to test their effects on behaviour.The experiments proposed here will aid in the design of more complex transgenic models of proteins aggregation in mental illness. They will also provide important insight into the potential value of such aggregates both as diagnostic biomarkers and as targets for future therapeutic interventions.]]></summary_en></project><project>
<id>7091</id><title_hr><![CDATA[Istraživanje i razvoj novih mikro i nanostrukturnih bioaktivnih materijala u dentalnoj medicini]]></title_hr><title_en><![CDATA[Investigation and Development of New Micro and Nanostructural Bioactive Materials in Dental Medicine]]></title_en><user_id>12362</user_id><user_firstLast_name>Ivana Miletić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2018-01</proposal_call><code>IP-2018-01-1719</code><acronim><![CDATA[BIODENTMED]]></acronim><duration>08.11.2018 - 07.11.2022</duration><status>Završio</status><financ_value>132.722,81 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Dentalna medicina, Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Dental medicine, Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Stomatološki fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Dentistry]]></institution_en><team_members_id>23313, 23312, 23320, 6401, 23315, 23323, 23317, 23316, 23310, 7026, 23344, 23340, 23341, 23365, 23355, 23354, 23357, 858408, </team_members_id><team_members_names><![CDATA[Silvana Jukić Krmek, Senka Meštrović, Hrvoje  Jurić, Željko Verzak, Anja Baraba, Jurica Matijević, Samir Čimić, Ana Ivanišević, Valentina Rajić, Zdravko Schauperl, Tanja Jurčević Lulić, Gorana Baršić, Jasna Leder Horina, Maja Bilić Prcić, Petra Bučević Sojčić, Marko Rajda, Marina Šimunović Aničić, Ivan Šalinović, ]]></team_members_names><keywords_hr><![CDATA[bioaktivnost, staklenoionomeri, kalcij silikatni cementi, vlakna, nanočestice, mikro CT, metoda konačnih elemenata]]></keywords_hr><keywords_en><![CDATA[bioactivity, glass-ionomers, calcium silicate cements, fibers, nanofillers, micro CT, finite element method]]></keywords_en><summary_hr><![CDATA[Svrha projekta je interdisciplinarno ispitivanje i poboljšanje svojstava bioaktivnih materijala koji se primjenjuju u različitim granama dentalne medicine. Prvi dio istraživanja usmjeren je na bioaktivne staklenoionomerne cemente. Ti materijali ostvaruju kemijsku vezu s površinom zuba, imaju remineralizirajući i kariostatski učinak. Međutim, njihovi nedostatci su još uvijek slaba fizičko-mehanička svojstva. Prvi cilj ovog projekta je istražiti mogućnost njihova poboljšanja dodavanjem staklenih vlakana i nanočestica u različitim omjerima te ispitati njihovu čvrstoću, tvrdoću, modul elastičnosti, remineralizacijski potencijal i adhezivnost na površinu zuba. U drugom dijelu istraživanja provest će se analiza biokeramike kao predstavnika novog bioaktivnog materijala za punjenje korijenskih kanala. Biokeramika bi trebala djelovati stimulativno na vitalno tkivo parodonta i dobro brtviti korijenski kanal. Stoga je drugi cilj projekta procijeniti odnos biokeramičkih materijala i strukture zuba u endodontskom prostoru ispitivanjem kvalitete brtvljenja ispuna korijenskog kanala biokeramikom prije i nakon dinamičkog opterećenja te mogućnost uklanjanja biokeramičkih materijala nakon revizije mikro CT analizom. Dinamičkim opterećenjem  nastoje se postići uvjeti slični onima u stomatognatom sustavu što je potrebno za ispravnu procjenu ponašanja materijala u kliničkim uvjetima. Temeljem podataka dobivenih laboratorijski i metodom konačnih elemenata odredit će se biomehanička i biomimetička svojstva istraživanih materijala. Originalnost predloženog istraživanja očituje se u sveobuhvatnom ispitivanju bioaktivnih materijala i doprinijet će boljem razumijevanju njihove strukture i svojstava te omogućiti razvoj poboljšanih protokola njihove kliničke primjene. Također, rezultati analize različitih ojačanja biomaterijala usmjerit će istraživanja prema njihovom daljnjem razvoju.]]></summary_hr><summary_en><![CDATA[The aim of the project is an interdisciplinary investigation and the enhancement of properties of bioactive materials properties used in different fields of dental medicine. The first part of the research is focused on bioactive glassionomer cements.  These materials chemically bond to the tooth surface and have a remineralizing and cariostatic effect. However, their disadvantages are poor physico-mechanical properties. The first aim of this project is to investigate the possibility of enhancing glassionomers by adding fibers and nanoparticles in different ratios and to assess the strength, hardness, modulus of elasticity, remineralizing potential and adhesion to the tooth surface.  Subsequently, the project will be focused on investigation of bioceramics as a representative of a new bioactive material for root canal filling. Bioceramics should stimulate the vital periodontal tissue and provide a good seal. Therefore, the second aim of the project is to assess the relation of bioceramic materials and tooth structure in the endodontic system by investigating the sealing ability before and after dynamic loading and the possibilities of the removal of bioceramics using micro CT. With dynamic loading, we are attempting to recreate the conditions similar to those in oral cavity which is necessary to correctly assess the behaviour of the materials under clinical conditions. With the data obtained in the laboratory and by finite element method biomechanical and biomimetic properties of the investigated materials will be determined. The originality of the proposed research lies in the detailed assessment of bioactive materials which should result in the better understanding of its structure and properties. It should also enable the development of better protocols for clinical application of the materials. Furthermore, the results of the analysis of different reinforcements of biomaterials will direct research towards enabling the materials to evolve even further.]]></summary_en></project><project>
<id>7092</id><title_hr><![CDATA[Kvantificiranje neodređenosti u formalizmu nuklearnih energijskih funkcionala gustoće ]]></title_hr><title_en><![CDATA[Uncertainty quantification within the nuclear energy density functional framework]]></title_en><user_id>780</user_id><user_firstLast_name>Tamara Nikšić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2018-01</proposal_call><code>IP-2018-01-5987</code><acronim><![CDATA[NucEDF]]></acronim><duration>01.10.2018 - 30.09.2022</duration><status>Završio</status><financ_value>132.722,81 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, </scie_field_hr><scie_field_en>Physics, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>12567, 19023, 23616, 11296, 25816, </team_members_id><team_members_names><![CDATA[Tomislav Marketin, Kosuke Nomura, Luka Gulin, Nils Paar, Giacomo Accorto, ]]></team_members_names><keywords_hr><![CDATA[Nuklearni energijski funkcionali gustoće, strukutra atomske jezgre, kolektivni modeli, fisija, Bayesian analiza]]></keywords_hr><keywords_en><![CDATA[Nuclear energy density functionals, structure of atomic nucleus, collective models, fission, Bayesian analysis]]></keywords_en><summary_hr><![CDATA[Opći cilj projekta NucEDF je razvoj i primjena inovativnog nuklearnog energijskog funkcionala gustoće koji bi osigurao precizna i pouzdana predviđanja svojstava osnovnog stanja i kolektivnih pobuđenja pokrivajući pritom cijelu kartu nuklida.Tijekom projekta ćemo formulirati i implementirati teorijski formalizam ne-empirijskih funkcionala kroz sljedeće specifične ciljeve: i) razvoj sljedeće generacije nuklearnih energijskih funkcionala gustoće zasnovanih na relativističkim nukleon-nukleon interakcijama izvedenim pomoću kovarijantne kiralne efektivne teorije polja, ii) razvoj sveobuhvatne baze podataka sa svojstvima osnovnog stanja i kolektivnih pobuđenja atomskih jezgri, iii) procjena primjenjivosti tehnika funkcionalne renormalizacijske grupe u razvoju nuklearnih energijskih funkcionala gustoće, iv) primjena Bayes-ovih metoda u analizi teorijskih neodređenosti raznih opservabli, v) unapređenje opisa procesa inducirane fisije, vi) unapređenje opisa procesa spontane fisije. Koristeći statističke metode i tehnike naprednog računarstva procijenit ćemo stabilnost i međusobne korelacije parametara nuklearnog energijskog funkcionala gustoće, izračunati neodređenost parametara i posljedičnu neodređenost izračunatih opservabli te ih uključiti u bazu podataka nuklearnih svojstava. Istražit ćemo utjecaj različitih stupnjeva slobode na proces fisije i izračunati distribucije fisionih fragmenata. Očekujemo da će projekt NucEDF pozitivno utjecati ne samo na zajednicu teorijskih nuklearnih fizičara, nego i na eksperimentalne nuklearne fizičare pružajući podršku postojećim i planiranim eksperimentalnim programima. Planirane aktivnosti će također ojačati kapacitete NucEDF projektnog tima u području naprednog računarstva.]]></summary_hr><summary_en><![CDATA[The project NucEDF will develop and apply novel nuclear energy density functional (EDF) capable to provide accurate and reliable predictions for the nuclear ground state properties and collective excitations over the entire nuclear chart. We will formulate and implement a framework for the non-empirical nuclear EDFs  with specific objectives: i) to develop the next generation  nuclear EDF  based on relativistic nucleon-nucleon interactions derived using covariant chiral effective field theory, ii) to develop comprehensive database containing nuclear ground state properties and collective excitations over the entire nuclear chart, iii) to assess the applicability of the functional renormalization group techniques in constructing the nuclear EDF, iv) to apply the Bayesian inference methods in an analysis of theoretical statistical uncertainties for various observables calculated with the newly developed EDF, v) to improve the description of the induced fission process within the EDF framework, vi) to improve the description of the spontaneous fission process within the EDF framework. Using statistical methods and advanced computing techniques, the stability and interdependence of the EDF parameters, the inherent parameter uncertainties and their propagation, and the corresponding uncertainties of predicted observables will be calculated and included in the developed database. Influence of various degrees of freedom on the fission process will be studied and the resulting distributions for the fission fragment yields will be calculated. The expected impact of the NucEDF project will influence not only the theoretical, but also the experimental nuclear physics community by providing support for the existing and planned experimental programmes. The planned activities will also strengthen the capacities of the NucEDF project team in the area of high-performance computing.  ]]></summary_en></project><project>
<id>7098</id><title_hr><![CDATA[Moderne misleće žene: Intelektualni razvoj žena u Hrvatskoj 20. stoljeća]]></title_hr><title_en><![CDATA[Modern Women Thinkers: Intellectual Development of Women in the 20th century Croatia]]></title_en><user_id>23254</user_id><user_firstLast_name>Andrea Feldman</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2018-01</proposal_call><code>IP-2018-01-3732</code><acronim><![CDATA[MMŽ/MWT]]></acronim><duration>01.10.2018 - 30.09.2022</duration><status>Završio</status><financ_value>50.036,50 eur</financ_value><scie_area_hr>Interdiciplinarne znanosti, Humanističke znanosti, Društvene znanosti, </scie_area_hr><scie_area_en>Interdisciplinary scientific area, Humanities, Social sciences, </scie_area_en><scie_field_hr>Povijest, Politologija, Sociologija, Filologija, Etnologija i antropologija, Obrazovne znanosti, Rodni studiji, </scie_field_hr><scie_field_en>History, Political Science, Sociology, Philology, Ethnology and anthropology, Educational sciences, Gender Studies, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Učiteljski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Teacher Education]]></institution_en><team_members_id>23255, 19116, 23270, 17872, 23529, 23774, 23668, </team_members_id><team_members_names><![CDATA[Marijana Kardum, Ida Ograjšek Gorenjak, Peto Andrea, Ana Batinić, Marci Shore, Tiina Kinnunen, Alenka Jensterle Doležal, ]]></team_members_names><keywords_hr><![CDATA[žene, intelektualna povijest, Hrvatska, kultura, obrazovanje, XX stoljeće ]]></keywords_hr><keywords_en><![CDATA[women, intellectual history, Croatia, culture, education, XX century]]></keywords_en><summary_hr><![CDATA[Projekt će se baviti konstrukcijom ženske intelektualne historije u Hrvatskoj, i identificirati idejne promjene u shvaćanju koncepta žene u 20. stoljeću kako bi se objasnila intelektualna ishodišta shvaćanja moderne žene. Pratit će se razvoj ideja koje su oblikovale prvenstveno žene vlastitim intelektualnim djelovanjem, utjecajem i kritikom mijenjajući tako društveni položaj žene i definiranjem kategorije intelektualca/ke. Istraživački fokus projekta smješten je u hrvatski te širi jugoslavenski i srednjeeuropski prostor od kraja 19. stoljeća do kraja 20. stoljeća. Razdoblje je to od pojave većeg sudjelovanja žena u društvenome i javnome životu s nakanom stjecanja potpune zakonske ravnopravnosti. Interdisciplinarno istraživanje obuhvatit će teorijske i prakseološke uvide iz historiografije, obrazovanja, teorije književnosti, antropologije, filozofije korištenjem domaće i strane literature i arhivske građe u nekoliko zemalja. Projekt će se baviti mehanizmima konstrukcije (nacionalnih, vjerskih, rodnih, klasnih, kulturnih) kolektivnih i individualnih identiteta ženske polovice stanovništva svih političkih uređenja na hrvatskom prostoru u vremenskom razdoblju od više od stoljeća. Ponudit će se kompleksnije razumijevanje utjecaja strukturnih promjena usred velikih društvenih, gospodarskih, kulturnih i političkih događaja promatranoga razdoblja. Projekt će istražiti osobe i ideje koje su kreirale promjene u razumijevanju (položaja) žene proučavanjem oblika i načina njihova društvenoga organiziranja i javnoga djelovanja (ženske organizacije, intelektualke: književnice, novinarke, učiteljice, profesorice, liječnice, umjetnice, znanstvenice, pripadnice društvene elite). Izrazita pozornost projekta usmjerena je neobjavljenoj i neistraženoj arhivskoj građi te nekonvencionalnim povijesnim izvorima javne i privatne provenijencije. ]]></summary_hr><summary_en><![CDATA[Project’s purpose is to construct intellectual history of women in Croatia and to detect ideological change in understanding of concept of woman in the first half of the 20th century. It will explain intellectual origins of modern woman in the context of changing social circumstances. It will trace development of ideas formulated by women in their intellectual endeavors, with their influence and criticism, changing their social position and defining the categories of intellectuals. The research is focused on Croat, Yugoslav and Central European space from the last decades of the 19th century to the end of the WWII. That period saw more active involvement of women in social and public life with an aim of achieving political and legal equality of women. The interdisciplinary research will encompass theoretical and practical insights in fields as diverse as history, education, literary theory, anthropology, philosophy.  International and domestic literature will be consulted, as well as archival sources in several countries. Project will reveal the mechanisms of construction of complex women&#39;s identities (both individual and collective) with reference to their national, religious, gender, class and cultural components. The aim is to understand life of women, during different political systems that reigned in this area through more than 50 years. Research will offer a complex understanding of structural changes that took place amidst great economic, social, cultural and political commotion. It will encompass personalities and ideas that created change in understanding of the status of women by study of the ways and forms of their social organizations and public actions (women&#39;s organizations, intellectuals, journalists, schoolteachers, professors, medical doctors, artists, scientists and members of society&#39;s elites). Focused on hitherto unpublished archival sources, the research will consult unconventional historical sources of public and private origins.]]></summary_en></project><project>
<id>7106</id><title_hr><![CDATA[Hrvatski renesansni aristotelizam: nova era u mišljenju prošlosti]]></title_hr><title_en><![CDATA[Croatian Renaissance Aristotelianism: New Era in Thinking the Past ]]></title_en><user_id>1441</user_id><user_firstLast_name>Pavel Gregorić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2018-01</proposal_call><code>IP-2018-01-4966</code><acronim><![CDATA[CRANEtp]]></acronim><duration>01.12.2018 - 30.05.2023</duration><status>Završio</status><financ_value>66.812,40 eur</financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Filozofija, Filologija, </scie_field_hr><scie_field_en>Philosophy, Philology, </scie_field_en><institution_hr><![CDATA[Institut za filozofiju]]></institution_hr><institution_en><![CDATA[Institute for Philosophy in Zagreb]]></institution_en><team_members_id>3931, 4860, 23272, 2634, 7132, </team_members_id><team_members_names><![CDATA[Gorana Stepanić, Šime Demo, Martino Rossi Monti, Ivana Skuhala Karasman, Dora Ivanisevic, ]]></team_members_names><keywords_hr><![CDATA[Aristotel, renesansa, Dubrovnik, filozofija, znanost]]></keywords_hr><keywords_en><![CDATA[Aristotle, Renaissance, Dubrovnik, philosophy, science]]></keywords_en><summary_hr><![CDATA[Za istraživanje hrvatskog renesansnog aristotelizma odabran je reprezentativni uzorak koji čine tri autora: Antun Medo (Dubrovnik, 1530 - Dubrovnik, 1600?), Nikola Vitov Gučetić (Dubrovnik, 1549 - Dubrovnik, 1610) and Matija Frkić (Krk, 1583 - Padova, 1669). Istraživanje će se fokusirati na šest djela navedenih autora: dva komentara Antuna Mede, tri komentara Nikole Vitova Gučetića i jednu aristotelovsku raspravu Matije Frkića. Tih šest djela pokrivaju polja logike, prirodne filozofije, psihologije, retorike i metafizike.         Osnovni ciljevi predloženoga projekta su (i) utvrditi i procijeniti glavne značajke i novíne hrvatskog renesansnog aristotelizma; (ii) prosuditi filozofsku relevantnost hrvatskog renesansnog aristotelizma; (iii) istražiti jezične specifičnosti hrvatskog renesansnog aristotelizma; (iv) prosuditi povijesnu i kulturnu relevantnost hrvatskog renesansnog aristotelizma; (v) dati stručnoj i široj javnosti hrvatske prijevode integralnih djela hrvatskog renesansnog aristotelizma, ali i temeljna djela antičkih autora koja su hrvatski renesansni aristotelovci tumačili.	Ovo je multidisciplinarno i interdisciplinarno istraživanje na raskrižju filozofije, filologije, povijesti ideja i kulturne povijesti, što se jasno ogleda u ekspertizama okupljenih suradnika na projektu. U različitim etapama istraživanja, i za različite ciljeve, koristit će se standardne filozofske, filološke i lingvističke metode.	Očekivani rezultati uključuju 5 uredničkih knjiga, 8 izvornih ili preglednih znanstvenih članaka (od kojih barem 4 u uglednim inozemnim časopisima), jedna međunarodna konferencija, 3 međunarodne radionice, desetak izlaganja rezultata ovog istraživačkog projekta na domaćim i inozemnim skupovima, jedan skup s izložbom prigodom 350. obljetnice smrti Matije Frkića (2019.). ]]></summary_hr><summary_en><![CDATA[For the purpose of our research on Croatian Renaissance Aristotelianism, a representative sample of three authors has been selected: Antun Medo (Dubrovnik, 1530 - Dubrovnik, 1600?), Nikola Vitov Gučetić (Dubrovnik, 1549 - Dubrovnik, 1610) and Matija Frkić (Krk, 1583 - Padova, 1669). The research will focus on six works by these authors: two commentaries by Antun Medo, three commentaries by Nikola Vitov Gučetić and one Aristotelian treatise by Matija Frkić. These six works cover the fields of logic, natural philosophy, psychology, rhetoric and metaphysics.      The basic research objectives of the proposed project are: (i) to identify and evaluate the main features and possible novelties of Croatian Renaissance Aristotelianism; (ii) to evaluate the philosophical relevance of Croatian Renaissance Aristotelianism; (iii) to explore the linguistic specificities of Croatian Renaissance Aristotelianism; (iv) to evaluate the historical and cultural relevance of Croatian Renaissance Aristotelianism; (v) to provide academic and wider Croatian public with translations of integral works of Croatian Renaissance Aristotelianism, as well as the fundamental works of ancient philosophers interpreted by Croatian Renaissance Aristotelian authors.      This is a multidisciplinary and interdisciplinary research at the intersection of philosophy, philology, history of ideas and cultural history, as reflected in the expertise of the team&#39;s collaborators. At different stages of the research, and for different purposes, the standard methods of philosophy, philology and linguistics will be used.      The expected results include 5 books, 8 research or overview articles (of which at least 4 in reputed international journals), one international conference, three international workshops, presentations of the results of this research project at conferences in Croatia and abroad, and a symposium and exhibition on the occasion of the 350th anniversary of Matija Frkić&#39;s death (2019).]]></summary_en></project><project>
<id>7109</id><title_hr><![CDATA[Novi spojevi temeljeni na bioizosterima purina za ispitivanje njihovih antitumorskih i antipatogenih djelovanja]]></title_hr><title_en><![CDATA[Novel purine bioisostere-based compounds for their anticancer and antipathogenic activity evaluations]]></title_en><user_id>76</user_id><user_firstLast_name>Silvana Raić-Malić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2018-01</proposal_call><code>IP-2018-01-4682</code><acronim><![CDATA[PurBioCaPa]]></acronim><duration>01.12.2018 - 30.11.2022</duration><status>Završio</status><financ_value>132.483,91 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, </scie_field_hr><scie_field_en>Chemistry, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet kemijskog inženjerstva i tehnologije]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Chemical Engineering and Technology]]></institution_en><team_members_id>22656, 1135, 3913, 2767, 13235, 6203, 17839, 23311, 3924, 23649, 28746, 861758, 22852, 864999, </team_members_id><team_members_names><![CDATA[Anja Harej, Andrijana Meščić, Silvija Maračić, Krešimir Pavelić, Ivana Stolić, Domagoj Drenjančević, Andrea Bistrović, John Kelly, Tatjana Gazivoda Kraljević, Sanja Kostrun, Valentina Rep, Anja Rakas, Željka Peršurić, Ivana Sokol, ]]></team_members_names><keywords_hr><![CDATA[purinski bioizosteri, benzimidazol, benzotiazol, 1,2,3-triazol, antitumorska, antibakterijska, antitripanosomska aktivnost]]></keywords_hr><keywords_en><![CDATA[purine bioisosteres, benzimidazole, benzothiazole, 1,2,3-triazole, anticancer, antibacterial, antitrypanosomal activity]]></keywords_en><summary_hr><![CDATA[S ciljem razvoja novih kemijskih entiteta sa snažnim i selektivnim antitumorskim, antibakterijskim i antitripanosomskim učinkom, predlažemo dizajniranje i sintezu novih purinomimetika primjenom strategije dizajniranja lijekova, poput bioizosterije i izmjene skeleta kod kojih se atomi dušika u aromatskom prstenu zamjenjuju atomom ugljika ili drugim heteroatomom. Derivati strukturno srodni purinima povezat će se s drugom farmakofornom jedinicom preko različitih premosnica kako bi se odredio njihov utjecaj na interakciju s molekulskom metom, a time i na biološku aktivnost. Radi ispitivanja moguće prednosti održivih sintetskih metoda u odnosu na tradicionalni pristup, uz klasične će se sintetske metode izabranih reakcija provesti i nekonvencionalne, poput mehanokemijskih i protočnih reakcija provedenih u mikroreaktoru. Kako bi se ostvario cilj predloženog projekta, nužno je koordinirano provođenje sinteze i optimiranje struktura, zajedno s metodama dizajniranja spojeva i ispitivanja njihovih bioloških djelovanja. Potom će se provesti antipatogena i citostatska ispitivanja s posebnim naglaskom na dodatna ispitivanja novopripravljenih spojeva na izabrane kemorezistentne tumorske stanične linije i bakterijske kliničke sojeve koji su rezistentni na postojeće antibiotike. Nadalje, za najdjelotvornije spojeve provest će se istraživanja molekulskog mehanizma djelovanja usmjerena na polinukleotide (DNA/RNA), odnosno enzime odabrane analizom in silico. Na temelju rezultata bioloških ispitivanja, ciljanim će se strukturnim modifikacijama optimirati strukture odabranih spojeva kandidata u svrhu poboljšanja njihove biološke aktivnosti i ADMET svojstava. Očekujemo da će u konačnici projekt rezultirati novim predvodnim spojevima sa selektivnim i učinkovitim antipatogenim, odnosno citostatskim djelovanjem, koji neće biti toksični, i koji će zadovoljiti potrebne kriterije za sljedeću fazu optimiranja predvodnog spoja.]]></summary_hr><summary_en><![CDATA[With the aim to develop new chemical entities with marked and selective anticancer, antibacterial and antitrypanosomal activity, we propose the design and synthesis of novel purinomimetics using the bioisosterism and scaffold hop by swapping nitrogen atoms with carbon and other heteroatoms in an aromatic ring. Purine-related derivatives will be linked to another pharmacophoric unit through various linkers to assess their impact on molecular target interaction and thereby biological activity. To evaluate the benefit of sustainable synthetic method to traditional approach, batch-based syntheses of chosen reactions will be translated to non-conventional, such as mechanochemical and micro-flow processes. In order to accomplish the aim of the proposed project, the synthesis and structure optimization along with drug design tools and biological evaluations will be performed in a coordinated manner. Furthermore, antipathogenic and cytostatic evaluations of newly prepared compounds will be performed emphasizing the additional assays on selected chemoresistant cancer cell line and antibiotic-resistant bacteria clinical strains. The molecular mechanism studies of the most effective compounds targeting polynucleotides (DNA/RNA) or enzymes, indicated by in silico analysis, will be subsequently carried out. On the basis of results of biological evaluations, structure optimization by chemical modification of selected compound candidates will be performed to improve their biological potency and ADMET properties. Finally, we expect that new lead compounds with selective and pronounced antipathogenic and/or cytostatic activities with no toxicity will be identified and satisfy necessary criteria for further lead optimization phase. ]]></summary_en></project><project>
<id>7116</id><title_hr><![CDATA[EKONOMSKI SENTIMENT: STATISTIČKI, POLITIČKI, BIHEVIORALNI I MEDIJSKI ASPEKTI NJEGOVOG UTJECAJA NA EKONOMSKU AKTIVNOST]]></title_hr><title_en><![CDATA[ECONOMIC SENTIMENT: STATISTICAL, POLITICAL, BEHAVIORAL, AND MEDIA ASPECTS OF ITS INFLUENCE ON ECONOMIC ACTIVITY]]></title_en><user_id>4385</user_id><user_firstLast_name>Petar Sorić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2018-01</proposal_call><code>IP-2018-01-4189</code><acronim><![CDATA[EconSent]]></acronim><duration>01.11.2018 - 31.10.2022</duration><status>Završio</status><financ_value>50.524,92 eur</financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Ekonomija, Politologija, Psihologija, </scie_field_hr><scie_field_en>Economy, Political Science, Psychology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Ekonomski fakultet u Zagrebu]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Economics and Business]]></institution_en><team_members_id>21201, 4299, 23425, 3912, 6252, 6659, 26644, </team_members_id><team_members_names><![CDATA[Marina Matošec, Mirjana Čižmešija, Oscar Claveria, Blanka Škrabić Perić, Ivana Lolić, Andrija  Henjak, Marija  Logarušić, ]]></team_members_names><keywords_hr><![CDATA[ankete pouzdanja poduzeća i potrošača, bihevioralna ekonomija, indeks neizvjesnosti ekonomske politike, strojno učenje, analiza medijskih sadržaja]]></keywords_hr><keywords_en><![CDATA[Business and Consumer Surveys, Behavioral Economics, Economic Policy Uncertainty Index, Machine Learning, Media Content Analysis]]></keywords_en><summary_hr><![CDATA[Svjetska financijska kriza jasno je pokazala da ekonomski modeli ne mogu adekvatno objasniti ni prognozirati događaje poput gospodarskog pada 2008.g. Ekonomisti su na to odgovorili uvođenjem latentnih varijabli poput sentimenta u svoje analize. Ključnu ulogu u tim nastojanjima imale su ankete pouzdanja poduzeća i potrošača, bogate baze podataka o medijskim izvještajima te razna ispitivanja političkog sentimenta.Ciljevi ovog projekta (proizašli iz neophodne multidisciplinarnosti ekonomskog istraživanja) su:1) Identificirati uzročne veze između ekonomskog sentimenta, medijskih sadržaja, rezultata anketa o političkim preferencijama i ekonomske aktivnosti2) Testirati perzistentnost političkog i ekonomskog sentimenta među EU zemljama i po gospodarskim sektorima3) Analizirati stupanj sinkronizacije ciklusa ekonomskog sentimenta između perifernih zemalja i jezgre EU4) Testirati hipotezu „nove umjerenosti“ nakon krize 2008. na političkom i ekonomskom sentimentu u pojedinim članicama EU 5) Razviti indeks iznenađenja temeljenog na BCS podacima i primijeniti ga u kratkoročnom prognoziranju ekonomske aktivnosti u pojedinim članicama EU6) Generirati ekonomske indikatore temeljene na anketnim podacima o očekivanjima pomoću evolucijskog programiranja7) Modificirati metodologiju indeksa neizvjesnosti ekonomske politike korištenjem tehnika strojnog učenja u svrhu osnaživanja njegovih vodećih karakteristika (primjena na SAD i Hrvatsku)Ovaj projekt trebao bi doprinijeti podizanju svijesti ekonomista o nužnosti koherentnog multidisciplinarnog pristupa analizi makroekonomskih fenomena. Korištenje anketa o političkom mnijenju i podataka iz medijskih izvještaja može pripomoći našem razumijevanju kompleksnosti ekonomskih procesa, kao i njihove međupovezanosti s društvenim kretanjima (politikom i medijima). Također, očekuje se da će prodiranje metoda strojnog učenja u ekonomiju u cijelosti unaprijediti kvalitetu prognoziranja standardnih vodećih ekonomskih pokazatelja.]]></summary_hr><summary_en><![CDATA[The global financial crisis has vividly demonstrated that economic models are not able to adequately explain (or forecast) extreme events such as the economic downfall in 2008. Economists have responded by introducing latent variables (such as economic agents’ sentiment) in their analyses. The pivotal role in these efforts has been assigned to Business and Consumer Surveys (BCS), rich news media datasets, and various political opinion polls.The goals of this project (stemming from the much-needed multidisciplinarity of economic research) are to:1)	Identify causal links between economic sentiment, news media contents, political opinion poll results and economic activity2)	Test the persistence of political and economic sentiment across EU countries and economic sectors3)	Analyze the synchronization degree of economic sentiment cycles between peripheral and core EU countries 4)	Test the “new modesty” hypothesis after the 2008 crisis on political and economic sentiment in EU Member States 5)	Develop a BCS-based surprise index and apply it in short-term forecasting of economic activity in individual EU Member States6)	Generate data-driven economic indicators from survey expectations by means of evolutionary computation7)	Modify the methodology of Economic Policy Uncertainty (EPU) Index by utilizing machine learning techniques in order to strengthen its leading characteristics (applications to USA and Croatia)This project should contribute to raising economists’ awareness of the necessity of a coherent multidisciplinary approach to assessing macroeconomic phenomena. Utilizing political opinion polls and news reports datasets might add to our understanding of the complexity of economic processes, as well as of their interrelationships with other social developments (politics and the media). Likewise, the penetration of machine learning into economics is expected to raise the overall forecasting quality of standard economic leading indicators.]]></summary_en></project><project>
<id>7131</id><title_hr><![CDATA[Odgovori na antisocijalne osobnosti u demokratskom društvu ]]></title_hr><title_en><![CDATA[Responding to antisocial personalities in a democratic society]]></title_en><user_id>4121</user_id><user_firstLast_name>Luca Malatesti</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2018-01</proposal_call><code>IP-2018-01-3518</code><acronim><![CDATA[RAD]]></acronim><duration>15.10.2018 - 14.10.2022</duration><status>Završio</status><financ_value>75.311,02 eur</financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Filozofija, Interdisciplinarne humanističke znanosti, </scie_field_hr><scie_field_en>Philosophy, Interdisciplinary humanities, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Filozofski fakultet u Rijeci]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Humanities and Social Sciences]]></institution_en><team_members_id>4172, 23385, 4815, 1453, 25808, 19830, 865224, </team_members_id><team_members_names><![CDATA[Marko Jurjako, Inti Angelo Brazil, John McMillan, Elvio Baccarini, Mia Biturajac, Ivan Cerovac, Mladen Bošnjak, ]]></team_members_names><keywords_hr><![CDATA[Neuroetika, psihijatrijska etika, antisocijalni poremećaj ličnosti, psihopatija, neuropsihologija, pučka psihologija, liječenje, moralno poboljšanje,]]></keywords_hr><keywords_en><![CDATA[Neuroethics, psychiatric ethics, antisocial personality disorder, psychopathy, treatment, moral enhancement, neuropsychology, folk psychology, ]]></keywords_en><summary_hr><![CDATA[Predloženi istraživački projekt istražit će etička pitanja koja se javljaju pri prevođenju i prenošenju znanstvenih spoznaja o antisocijalnim osobnostima na društvene prakse unutar demokratskog društva. Cilj je povezati ili sučeliti najznačajnije rezultate trenutno dostupnih znanstvenih spoznaja o antisocijalnom ponašanju s normativnim okvirom koji bi trebao potkrijepiti etičke preporuke o liječenju, intervenciji, poboljšanju i prevenciji kriminalaca i drugih osoba s tim poremećajima. U fokusu istraživanja se nalaze dva općenita i hitna teorijska izazova. Jedan je problem povezivanja ili sučeljavanja normativnog pojma osobe i njezinih kognitivnih moći i sposobnosti za odlučivanje sa znanstvenim koncepcijama i spoznajama o tim sposobnostima. Normativni pojam osobe se elaborira u filozofskim i pravnim teorijama kriminalne i moralne odgovornosti koje podrazumijevaju postojanje sposobnosti za racionalno odlučivanje i autonomiju. Drugi je problem artikuliranje normativnog okvira za primjenu na dva međusobno povezana normativna zadatka. Prvo, ovaj okvir mora dati formu opravdanja za pojam normativne osobe koji sam ne smije biti obilježen spornim metafizičkim gledištima već mora biti definiran u terminima koji su prihvatljivi unutar pluralističkog i demokratskog društva. Drugo, normativni okvir mora nas voditi prema praktičnim rješenjima o tome kako reagirati na pojedince s antisocijalnim poremećajima osobnosti, koja mogu biti prihvatljiva svim racionalnim članovima pluralističkog i demokratskog društva. ]]></summary_hr><summary_en><![CDATA[The proposed research project will investigate the ethical issues raised by translating scientific advances in the study of antisocial personalities to the social practices of a democratic society. The aim is to interface the most remarkable results of current science of antisocial behaviour with a normative framework that should underpin ethical recommendations on the treatment, intervention, enhancement and prevention that target offenders and other individuals with these disorders.Two general and pressing theoretical challenges will be at the core of the proposed investigation. One is the problem of interfacing the normative notion of a person and her cognitive and decision-making faculties with scientific conceptions of those faculties. The normative notion of a person is spelled out in philosophical and legal accounts of criminal and moral responsibility that presuppose having capacities for rational decision-making and autonomy. The other is the problem of articulating a normative framework for applying it to two interrelated normative tasks. First, this framework must inform the justification of a notion of the normative person that, being not hostage to metaphysically contestable views, is acceptable within a pluralistic democratic society. Second, it would guide our practical resolutions about how to respond to individuals with antisocial personalities that is viable in a pluralistic democratic society.]]></summary_en></project><project>
<id>7134</id><title_hr><![CDATA[Influence of redox status on psychostimulant-induced neural plasticity]]></title_hr><title_en><![CDATA[Utjecaj redoks stanja na neuralnu plastičnost izazvanu psihostimulansima]]></title_en><user_id>69</user_id><user_firstLast_name>Rozi Andretić Waldowski</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2018-01</proposal_call><code>IP-2018-01-2794</code><acronim><![CDATA[DrugPlast]]></acronim><duration>01.01.2019 - 31.12.2022</duration><status>Završio</status><financ_value>132.722,81 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Biologija, </scie_field_hr><scie_field_en>Biology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci]]></institution_hr><institution_en><![CDATA[University of Rijeka]]></institution_en><team_members_id>20232, 23605, 5439, 8313, 4624, 28669, 855438, </team_members_id><team_members_names><![CDATA[Sanja Radman, Jorge Campusano, Ralph Greenspan, Rainer  Spanagel, Ana Filošević, Franka Rigo, Milan Petrović, ]]></team_members_names><keywords_hr><![CDATA[neuralna plastičnost, psihostimulansi, redoks, genetika, ponašanje, Drosophila]]></keywords_hr><keywords_en><![CDATA[neuronal plasticity, psychostimulants, redox, genetics, behavior, Drosophila]]></keywords_en><summary_hr><![CDATA[Opojne droge mijenjaju funkcije mozga i dovode do ovisnosti aktivirajući mehanizme neuralne plastičnosti. Drosophila melanogaster je do sada uspješno korištena kao model organizam za ispitivanje utjecaja opojnih droga na živčani sustav radi sličnosti na nivou gena, neurotransmitera i mehanizama kojima droge mijenjaju mozak.Naši preliminarni rezultati pokazuju da promjena redoks ravnoteže u Drosophile onemogućava razvoj lokomotorne senzitizacije na metamfetamin (METH) i kokain. Na osnovu tih otkrića predlažemo ispitati kako promijene u redoks ravnoteži utječu na neuralnu plastičnost izazvanu psihostimulansima. Naša hipoteza je da lokomotorna senzitizacija, kao oblik neuralne plastičnosti, ovisi o redoks stanju.Imamo tri glavna cilja:a) identificirati gene koji reguliraju redoks stanje i utječu na regulaciju lokomotorne senzitizacije na METH, b) identificirati u kojim dijelovima mozga je ekspresija gena koji reguliraju redoks stanje važna za regulaciju lokomotorne senzitizacije, i c) identificirati funkcionalne promijene na nivou otpuštanja biogenih amina, aktivacije antioksidativnih enzima i količine reaktivnih kisikovih vrsta koje su povezane s razvojem lokomotorne senzitizacije.Kako bi ostvarili te ciljeve koristiti ćemo niz komplementarnih pristupa koji će nam omogućiti da analiziramo neuralnu plastičnost na nivou ponašanja i genetike, transkriptomike, proteomike, elektrofiziologije i biokemije kako bi karakterizirali odgovorne gene i proteine.Ishodi ovoga projekta pridonijeti će razumijevanju osnovnih genetskih mehanizama koji su aktivirani opetovanom administracijom psihostimulansa. Očekujemo da će ishodi ovoga projekta pomoći u razumijevanju bazičnih principa neuralne plastičnosti općenito. Radi značajnog utjecaja redoks ravnoteže na stanične funkcije, naši rezultati mogu sugerirati jednostavne strategije za spriječavanje i tretman ovisnosti.]]></summary_hr><summary_en><![CDATA[Drugs of abuse change brain functioning and lead to addiction engaging mechanisms of neuronal plasticity. Drosophila melanogaster has successfully been used as a model organism to study action of addictive drugs on the nervous system because of the conservation at the levels of genes, neurotransmitters and mechanisms of change that drugs induce. Our preliminary data shows that in Drosophila the change in the redox balance interferes with the development of locomotor sensitization to methamphetamine (METH) and cocaine. Based on these findings we propose to investigate how do changes in the redox balance regulate drug-induced neuroplasticity. Our hypothesis is that locomotor sensitization, as one form of neuroplasticity, depends on redox status. We have three main objectives: a) to identify genes involved in redox regulation that affect development of locomotor sensitization to METH, b) to identify brain areas where expression of genes regulating redox balance is required for development of locomotor sensitization, and c) to identify functional changes at the level of the release of bigenic amines, activity of antioxidant enzymes and amount of reactive oxidative species that are correlated with development of locomotor sensitization. To achieve these objectives we will use number of different complementary approaches that will enable us to analyze neuronal plasticity at the level of behavior and genetics, transcriptomics, proteomics, electrophysiology and biochemistry to functionally characterize candidate genes and proteins.Outcomes of this study will contribute in the understanding of basic genetic mechanisms that are triggered with repeated administrations of psychostimulants. We expect that outcomes of this study will help in the understanding of basic principles of neuronal plasticity in general. Because of the wide influence of redox balance on cell functioning, our results may result in simple strategies for prevention and treatment of addiction.]]></summary_en></project><project>
<id>7147</id><title_hr><![CDATA[Razvoj održivog integriranog procesa proizvodnje biološki aktivnih izolata iz proizvodnih ostataka prehrambene industrije]]></title_hr><title_en><![CDATA[Development of a sustainable integrated process for the production of bioactive isolates from food industry residues]]></title_en><user_id>4070</user_id><user_firstLast_name>Ana  Bucić-Kojić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2018-01</proposal_call><code>IP-2018-01-1227</code><acronim><![CDATA[POPI-WinCEco]]></acronim><duration>31.10.2018 - 30.10.2022</duration><status>Završio</status><financ_value>132.237,04 eur</financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Prehrambena tehnologija, Interdisciplinarne biotehničke znanosti, </scie_field_hr><scie_field_en>Food technology, Interdisciplinary biotechnical sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište Josipa Jurja Strossmayera u Osijeku, Prehrambeno-tehnološki fakultet]]></institution_hr><institution_en><![CDATA[Josip Juraj Strossmayer University of Osijek, Faculty of Food Technology]]></institution_en><team_members_id>4717, 23326, 23393, 6811, 23651, 309, 1277, 25658, 856193, </team_members_id><team_members_names><![CDATA[Mirela Planinić, Gordana Šelo, Katarina Jukić, Daliborka Koceva Komlenić, Ana Šušak, Marina Tišma, Katarina Mišković Špoljarić, Josipa Grgić, Gabriela Perković, ]]></team_members_names><keywords_hr><![CDATA[proizvodni ostaci, biološki aktivni izolati, polifenoli, biološka obrada, ekstrakcija, sušenje, enkapsulacija, funkcionalni proizvod, bioraspoloživost]]></keywords_hr><keywords_en><![CDATA[food industry residues, bioactive isolates, polyphenols, biological treatment, extraction, drying, encapsulation, functional product, bioaccessibility]]></keywords_en><summary_hr><![CDATA[U prehrambenoj industriji zaostaju značajne količine proizvodnih ostataka (POPI) koji se uglavnom odbacuju iako po svom kemijskom sastavu imaju potencijal za daljnje korištenje u proizvodnji visokovrijednih produkata (npr. biološki aktivnih izolata bogatih polifenolnim spojevima, BAI). POPI biljnog porijekla su uglavnom teško razgradivi lignocelulozni materijali koji u svojoj strukturi sadrže inkorporirane polifenole, koji su zbog toga teško ekstraktibilni ili imaju nisku bioraspoloživost. Ekstrakcija teško topljivih polifenola zahtjeva dodatne postupke razgradnje (npr. kiselinama ili komercijalnim enzimima), koji povećavaju troškove proizvodnje i/ili nisu ekološki prihvatljivi. Fermentacija na čvrstim nosačima (solid-state fermentation, SSF) je bioproces koji ima veliki potencijal za pretvorbu otpada poljoprivredne i prehrambene proizvodnje u visokovrijedne produkte, među kojima su i BAI, na ekološki prihvatljiv način. Cilj ovog projekta je razviti održivi integrirani proces proizvodnje BAI-a iz POPI-a (trop grožđa; mekinje i pljevica žitarica) biljnog porijekla, pri čemu će se POPI prvo obraditi filamentoznim gljivama u SSF uvjetima, nakon čega će se koristiti za proizvodnju BAI a pomoću ekstrakcije otapalom. Razvit će se i protokoli stabilizacije BAI-a, primjenom suvremenih tehnologija (enkapsulacijom, sušenjem raspršivanjem, liofilizacijom), te će se odrediti antioksidacijska i antitumorska aktivnost BAI-a u in vitro uvjetima. Proizvedeni BAI koristiti će se kao dodaci u proizvodnji funkcionalnog keksa i srodnih proizvoda. Simuliranim procesom probave u in vitro uvjetima, ispitat će se bioraspoloživost polifenola iz BAI-a i funkcionalnog keksa. Rezultati predloženog projekta imat će pozitivne ekonomske i društvene utjecaje kroz razvoj ekološki prihvatljivog procesa proizvodnje BAI-a, minimiziranje količine otpada iz prehrambene industrije, povećanje dodane vrijednosti proizvoda, te indirektan utjecaj na ljudsko zdravlje kroz proizvodnju funkcionalnih proizvoda.]]></summary_hr><summary_en><![CDATA[There are significant amounts of residues from the food industry (POPI) which are usually discarded even though their chemical composition gives them the potential to be further used in the production of high-value products (e.g. biologically active polyphenol rich isolates, BAI). The POPI of plant origin are mostly lignocellulosic materials recalcitrant towards degradation, and incorporate polyphenolic compounds in its structure. Those polyphenolic compounds are difficult to be extracted, thus have low bioaccessibility. Extraction of low soluble polyphenols requires additional processes of degradation by e.g. acids or commercial enzymes, which increase the costs of production and/or are not environmentally friendly. Solid-state fermentation (SSF) has a great potential for conversion of agro-food industry residues into numerous high-value products, including BAI, in an environmentally friendly way. The goal of this project is to develop a sustainable integrated process for the production of BAI from POPI (grape pomace; bran and hull of cereals) where the POPI will be initially treated with filamentous fungi in SSF conditions. After the treatment it will be used for the production of BAI using solvent extraction. Protocols for the stabilization of BAI will be developed by using state-of-the-art technologies (spray drying, freeze-drying, encapsulation) and antioxidative and antitumor activity of BAI will be determined in in vitro conditions. Stable BAI will be used in the production of functional cookies and crackers. Through the simulated process of digestion in in vitro conditions, polyphenol bioaccessibility from the BAI and functional products will be tested. The results of the proposed project will have positive economic and social effects through development of environmentally friendly process for BAI production, minimization of food industry waste, increase of added product value, and indirect impact on human health through development of functional products.]]></summary_en></project><project>
<id>7156</id><title_hr><![CDATA[Kombinatorički objekti i kodovi]]></title_hr><title_en><![CDATA[Combinatorial objects and codes]]></title_en><user_id>885</user_id><user_firstLast_name>Dean Crnković</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2018-01</proposal_call><code>IP-2018-01-6732</code><acronim><![CDATA[COCo]]></acronim><duration>01.01.2019 - 31.12.2022</duration><status>Završio</status><financ_value>130.068,35 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Matematika, </scie_field_hr><scie_field_en>Mathematics, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Fakultet za matematiku]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Mathematics]]></institution_en><team_members_id>919, 5381, 5935, 907, 4515, 4484, 1089, 3161, 3468, 3226, 23476, 23496, 4992, 23495, 23513, 17780, 28994, </team_members_id><team_members_names><![CDATA[Sanja Rukavina, Mario Osvin Pavčević, Vedran Krčadinac, Vedrana Mikulić Crnković, Andrea Švob, Anamari Nakić, Doris Dumičić Danilović, Marija Maksimović, Nina Mostarac, Marina Šimac, Sara Ban, Ivona Novak, Kristijan Tabak, Tin Zrinski, Matteo Mravić, Renata Vlahović, Daniel Hawtin, ]]></team_members_names><keywords_hr><![CDATA[kombinatorički dizajn, graf, Hadamardova matrica, konačna grupa, kod]]></keywords_hr><keywords_en><![CDATA[combinatorial design, graph, Hadamard matrix, finite group, code]]></keywords_en><summary_hr><![CDATA[U sklopu ovog projekta konstruirat će se i analizirati različiti tipovi kombinatoričkih dizajna i grafova. Kombinatoričke strukture konstruirat će se kombiniranjem računalnih, geometrijskih i algebarskih metoda. Proučavat će se i drugi kombinatorički objekti, kao što su binarni komplementarni nizovi (npr. periodični Golayjevi parovi) i Hadamardove matrice (uključujući kompleksne Hadamardove matrice). Također će se proučavati veza s drugim strukturama, na primjer s konačnim geometrijama i asocijacijskim shemama. Konačne grupe imat će značajnu ulogu u konstrukciji i analizi kombinatoričkih struktura. Nadalje, u sklopu projekta konstruirat će se i analizirati kodovi, posebno linearni kodovi dobiveni iz kombinatoričkih dizajna, grafova, binarnih nizova i Hadamardovih matrica. Kao rezultate predloženog istraživanja očekujemo konstrukcije i klasifikacije različitih tipova kombinatoričkih dizajna i grafova (npr. novih blokovnih dizajna i jako regularnih, odnosno distance regularnih, grafova) i drugih kombinatoričkih objekata (komplementarnih nizova, Hadamardovih matrica, itd.), kao i konstrukciju kodova s dobrim svojstvima (npr. linearnih kodova s velikom minimalnom udaljenošću s obzirom na duljinu i dimenziju koda, samodualnih kodova, itd.). Očekujemo da će rezultati ovog projekta biti zanimljivi znanstvenicima koji rade u području teorije dizajna, teorije kodiranja i teorije grafova, kao i onima koji se bave istraživanjima u području teorije konačnih grupa.  ]]></summary_hr><summary_en><![CDATA[This project deals with construction and analysis of various types of combinatorial designs and graphs. For construction of combinatorial structures we will combine computational, geometric and algebraic approach. We will also take into consideration other combinatorial objects, such as binary complementary sequences (e.g. periodic Golay pairs) and Hadamard matrices (including complex Hadamard matrices). Relations to other structures (finite geometries, association schemes, etc.) will also be taken into account. Finite groups actions will have a significant role in constructing and analysing combinatorial structures. Further, we will work on construction and analysis of codes, mostly linear codes that can be obtained from combinatorial designs, graphs, binary sequences and Hadamard matrices.As a result of the proposed research, we expect a construction and classification of various types of combinatorial designs and graphs (e.g. new block designs and strongly/distance regular graphs) and other combinatorial objects (complementary sequences, Hadamard matrices, etc.), as well as a construction of codes with good properties (e.g. linear codes with large minimum distance comparing to the length and the dimension of the code, self-dual codes, etc.). We expect that the outcomes of this project will be of interest for researchers working in design theory, coding theory and graph theory, and for those working in theory of finite groups.  ]]></summary_en></project><project>
<id>7157</id><title_hr><![CDATA[Utjecaj gospodarenja i klimatskih promjena na dinamiku rasta stabala i sastojina jele Dinarskog područja Hrvatske]]></title_hr><title_en><![CDATA[Influence of management and climate on Silver fir trees and stand growth dynamics in Croatian Dinarides]]></title_en><user_id>13792</user_id><user_firstLast_name>Jura Čavlović</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2018-01</proposal_call><code>IP-2018-01-8820</code><acronim><![CDATA[FirGroDin]]></acronim><duration>01.11.2018 - 31.10.2022</duration><status>Završio</status><financ_value>127.821,36 eur</financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Šumarstvo, </scie_field_hr><scie_field_en>Forestry, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet šumarstva i drvne tehnologije]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Forestry and Wood Technology]]></institution_en><team_members_id>12737, 13518, 13572, 5728, 20509, 13381, 23555, 5743, 22673, </team_members_id><team_members_names><![CDATA[Mislav Vedriš, Tomislav Levanič, Ernest Goršić, Stjepan Posavec, Mario Božić, Krunoslav Teslak, Andrej Bončina, Karlo Beljan, Marijana Žunić, ]]></team_members_names><keywords_hr><![CDATA[razvoj sastojina, obična jela, režim gospodarenja, klimatske promjene, dendrokronologija, prirodne nepogode ]]></keywords_hr><keywords_en><![CDATA[Stand Development, Silver Fir, Management Regime, Climate Change, Dendrochronology, Natural Disasters]]></keywords_en><summary_hr><![CDATA[Uz jelove šume najčešće je vezan pristup prebornog gospodarenja koji je tip prirodi bliskog gospodarenja kao opći trend šumarstva Europe i svijeta, ali također uz jelu već je više godina povezan i pojam odumiranja šuma. Pokazatelji karakteristični za odumiranje stabala jele su gubitak vitalnosti, smanjeni rast i porast mortaliteta. Opće prihvaćena teorija o propadanju jele je povezanost između poremećaja u rastu i povećanog mortaliteta s onečišćenjem zraka (emisijama SO2) u kompleksnoj interakciji s klimatskim i biotskim faktorima, ali i postupcima gospodarenja. O potrebama za dugoročnim monitoringom šumskih ekosustava u uvjetima narušavanja njihove stabilnosti svjedoče brojni projekti i inicijative u Europi za sustavno praćenje ekološke stabilnosti, raznolikosti i prilagodbe šumskih ekosustava klimatskim promjenama. U Hrvatskoj nema primjera sveobuhvatnog i sustavnog istraživanja i praćenja šumskih ekosustava šireg prostora. Zbog navedenog značaja i promjena uslijed utjecaja gospodarenja i okolišnih čimbenika šuma jele Dinarskog područja na nacionalnoj i europskoj razini, ovaj projekt je predložen s ciljem uspostave i provedbe sveobuhvatnog sustava monitoringa i istraživanja šuma jele na cijelom području hrvatskih Dinarida. Na podlozi od 80 trajnih pokusnih ploha provelo bi se istraživanje i praćenje dugogodišnjeg i postojećeg utjecaja klimatskih i okolišnih čimbenika i režima gospodarenja na stanje i dinamiku stabala i sastojina jele. U sustav trajnih ploha koje pokrivaju gradijent klime, utjecaja onečišćenja i areala, te stanišne i gospodarske značajke na konzistentan način integriran je ograničeni uzorak ploha i stabala za detaljno praćenje i istraživanje. Razmjena rezultata i iskustava istraživane problematike te afirmacija istraživačke skupine i posljedično uključivanje u istraživačke projekte na međunacionalnoj razini krajnji je očekivani rezultat ovog projekta.]]></summary_hr><summary_en><![CDATA[Silver fir forests are nowadays mostly associated with selection forest management approach, being a type of close to nature forest management that is a general trend of European and world forestry. Other characteristic of fir forest is the forest decline. Impaired fir trees are typically characterized by loss of vitality, growth reduction and higher mortality. The most recent and widely accepted hypothesis of silver fir decline is that the growth decrease and higher mortality rate in the second half of twentieth century, along with its recovery afterwards, were linked to air pollution (SO2 emissions) in interaction with climatic and biotic factors, and also management approaches. Numerous projects and incentives in Europe on systematic monitoring of ecological stability, biodiversity and adaptation of forest ecosystems to climate changes indicate needs for long-term monitoring of forest ecosystems of disturbed stability. In Croatia, there are almost no examples of systematic monitoring and research of forest ecosystems on landscape level. Based on evidenced importance and caused changes of the silver fir-beech Dinaric forests on national and Europe level, this project is proposed in order to establish and conduct consistent monitoring and research silver fir forests within entire Dinaric region of Croatia. Research will be based on 80 permanent plots for monitoring of past and current influences of climatic and environmental factors and management regimes on current state and dynamics of silver fir trees and stands. The system of permanent plots covering gradient of climate, air emission and spread, site and management characteristics will include plots and trees for detailed and intensive measurements. The exchange of results and experience, and affirmation of the project research group with consequential integration in research projects on international level are expected results of this project.]]></summary_en></project><project>
<id>7159</id><title_hr><![CDATA[Oklapanje od elektromagnetskih polja električki vodljivim tekstilnim materijalima]]></title_hr><title_en><![CDATA[Shielding from electromagnetic fields with electrically conductive textile materials ]]></title_en><user_id>19352</user_id><user_firstLast_name>Krešimir Malarić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2018-01</proposal_call><code>IP-2018-01-7028</code><acronim><![CDATA[SEMECTEX]]></acronim><duration>01.12.2018 - 30.11.2022</duration><status>Završio</status><financ_value>128.626,45 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Elektrotehnika, Tekstilna tehnologija, </scie_field_hr><scie_field_en>Electrical engineering, Textile technology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id>5841, 328, 13106, 6949, </team_members_id><team_members_names><![CDATA[Tanja Pušić, Martin Dadić, Bosiljka Šaravanja, Damir Muha, ]]></team_members_names><keywords_hr><![CDATA[elektromagnetska polja, tekstilni materijali, učinkovitost oklopa, elektromagnetsko zračenje, zaštita od elektromagnetskih polja]]></keywords_hr><keywords_en><![CDATA[electromagnetic fields, textile materials, shielding effectiveness, electromagnetic radiation, electromagnetic field protection ]]></keywords_en><summary_hr><![CDATA[Elektromagnetsko polje na mikrovalnim frekvencijama nalazi se svuda oko nas: mobilni telefoni, Wi-Fi, tableti, mikrovalne pećnice, itd... Današnji način života zahtjeva od ljudi kontinuiranu uporabu sve više i više elektroničkih uređaja. Najveći broj odašiljača radi na frekvencijama između 900 MHz i 2,4 GHz. To uključuje GSM telefone i bazne postaje (900 MHz i 1800 MHz) te Wi-Fi (2,4 GHz). Dok s jedne strane većina ljudi ne želi u blizini imati bazne postaje GSM-a, gotovo nitko se ne želi lišiti mogućnosti koje pruža pokretni telefon ili tablet. Danas se sve više ljudi želi zaštiti od elektromagnetskog polja. Potpuna zaštita od elektromagnetskog polja na mikrovalnim frekvencijama je nemoguća. Ona bi uključivala neku vrstu Faradayevog kaveza, ali tada komunikacija ne bi bila moguća, tj. elektromagnetski signal ne bi mogao doprijeti od odašiljača do prijamnika. Elektromagnetsko oklapanje jedna je mogućnost zaštite od elektromagnetskog zračenja. Kod ljudi, ta zaštita može biti u vodljivim tekstilnim materijalima koji se ugrađuju u odijela ili kape. Vodljivi materijali mogu se ugrađivati i u tapete ili zavjese radi zaštite od vanjskih elektromagnetskih polja. Danas na tržištu postoje tekstilni materijali s metalnim nitima uglavnom od srebra ili bakra. Ti materijali su vrlo lagani ali dosta skupi. Cilj predloženog istraživanja je analiza postojećih tekstilnih materijala s vodljivim nitima od srebra i bakra za elektromagnetsko oklapanje. Tijekom istraživanja na projektu razvile bi se metode mjerenja učinkovitosti vodljivih tekstilnih oklopa na frekvencijama od 900 MHz do 2,4 GHz, te mogućnost njihove primjene kod zaštite ljudi. Ispitala bi se i trajnost, odnosno životni ciklus vodljivih tekstilnih materijala tijekom uporabe i njege.  ]]></summary_hr><summary_en><![CDATA[Electromagnetic fields on microwave frequencies are present everywhere around us: mobile phones, W-Fi, tablets, microwave owens, etc. Today way of living demands from people continuous use of many electronic devices. The large number of transmitters nowadays works on frequencies between 900 MHz and 2.4 GHz. This includes GSM phones and base stations (900 MHz and 1800 MHz) and Wi-Fi (2.4 GHz). While on one hand most people do not want to live in vicinity of GSM base station, almost nobody wants to deprive himself from the advantages offered by mobile phone or tablet. Today, more and more people want to protect themselves from the electromagnetic field radiation. Complete protection from the electromagnetic fields on microwave frequencies is impossible. It would include some sort of Faraday cage, but then the communication would not be possible, that is; electromagnetic signal could not travel from transmitter to the receiver. Electromagnetic shielding is one possibility of protection from electromagnetic radiation. For humans, this protection can be conductive textile materials inserted in suits or hats. Furthermore, conductive materials can be built in wallpaper or curtains for protection from environmental electromagnetic fields. Today, on the market there are textile materials with metal threads mostly from copper or silver. These materials are very light but quite expensive. The aim of proposed research is the analysis of existing textile materials with conductive copper or silver threads for electromagnetic shielding. Research would include development of measurement methods of shielding effectiveness of conductive textile shields on frequencies from 900 MHz to 2.4 GHz as well as their possible application on humans. Furthermore, the durability and life cycle of the mentioned textile materials during use and caring. ]]></summary_en></project><project>
<id>7174</id><title_hr><![CDATA[3D mreže kompleksnih Ge-baziranih nanostruktura u staklima: svojstva i primjene]]></title_hr><title_en><![CDATA[3D networks of complex Ge-based nanostructures in glasses: properties and applications]]></title_en><user_id>1362</user_id><user_firstLast_name>Maja Buljan</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2018-01</proposal_call><code>IP-2018-01-3633</code><acronim><![CDATA[NetNano]]></acronim><duration>01.09.2018 - 31.08.2022</duration><status>Završio</status><financ_value>158.506,20 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, Kemija, Biologija, Interdisciplinarne prirodne znanosti, </scie_field_hr><scie_field_en>Physics, Chemistry, Biology, Interdisciplinary natural sciences, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>2755, 17815, 21310, 20255, 5657, 3154, 5438, 23403, 3526, 23459, 24100, 329, 27507, 864982, 865363, 865362, 865408, </team_members_id><team_members_names><![CDATA[Ivančica Bogdanović Radović, Nikolina Nekić, Lovro Basioli, Iva Šarić, Krešimir Salamon, Igor Mekterović, Branko Šantić, Božidar Benko, Tihomir Car, Joško Erceg, Dario Mičetić, Nikola Biliškov, Marija Tkalčević, Ivana Periša, Gabrijela Svalina Svalina, Senad Isaković, Marija Šimat, ]]></team_members_names><keywords_hr><![CDATA[nanostrukture, samouređenje, Ge, konverzija energije, pohrana energije, zelena energija]]></keywords_hr><keywords_en><![CDATA[nanostructures, self-assembly, Ge, energy conversion, energy storage, green energy]]></keywords_en><summary_hr><![CDATA[Tijekom proteklih nekoliko godina razvili smo novu klasu materijala baziranih na pravilno uređenim Ge kvantnim točkama (KT) unutar staklene matrice. Ti materijali se pripremaju depozicijom magnetronskim rasprašenjem te naknadnim grijanjem i/ili zračenjem teškim ionima. Ovim projektom planiramo unaprijediti naše istraživanje na novu razinu istražujući kompleksne Ge-bazirane nanostrukture u staklima i njihovu primjenu u uređajima za visoko-učinkovitu konverziju energije  i njeno skladištenje.Naime, svojstva materijala baziranih na čistim, sferičnim Ge KT-ma mogu biti značajno poboljšana ili ciljano dizajnirana dodatkom drugog materijala na Ge KT-e obliku ljuske, pokrovnog sloja ili njihovom izradom u nekom kompleksnijem obliku. Ovi novi materijali, bazirani na kompleksnim Ge nanostrukturama, vrlo su zanimljivi za fundamentalnu znanost, dok njihova visoko prilagodljiva svojstva osiguravaju mogućnost primjene u modernim opto-elektroničkim uređajima.  Očekujemo uspješnu izradu nekoliko novih kompleksnih materijala, uključujući Ge/metal  jezgra/ ljuska KT-e, kontinuirane 3D mreže Ge nanožica i specifične nano-objekte nastale djelovanjem iona u različitim matricama. Razumjet ćemo kako njihova optička i električna svojstva ovise o njihovoj strukturi, te kako ih prilagoditi da bi dobili željena svojstva potrebna za primjene. Kao konačni cilj, iskoristit ćemo ih za proizvodnju energetski učinkovitih staklenika, visoko učinkovite elektrode za cijepanje vode i Li-ion baterije te za spremnike vodika.U konačnici očekujemo da će predloženi projekt donijeti važne rezultate za rješavanje aktualnih problema vezanih uz proizvodnju energije i zdrave hrane te čišćenje okoliša. Također očekujemo širenje znanstvene zajednice zainteresirane za ovu novu vrstu materijala. Ti materijali i uređaji imaju veliki potencijal da budu masovno proizvedeni i primijenjeni u suvremenoj nanotehnologiji budući da je magnetronsko rasprašenje standardna industrijska tehnika za oblaganje stakala.]]></summary_hr><summary_en><![CDATA[During the past several years we have developed a new material class based on regularly distributed Ge quantum dots (QDs) within the glass matrix. These materials are prepared by magnetron sputtering deposition followed by annealing and/or irradiation with heavy ions. We propose to advance our research to a new level by exploring complex Ge-based nanostructures in glasses and their applications in highly-efficient energy conversion and storage devices. Namely, the properties of materials based on pure, spherical Ge QDs can be significantly improved or designed specifically by addition of another material to Ge QDs in form of shell or capping layer, or by creating them to have some more complex shape. These new materials, based on complex Ge nanostructures, are very interesting from the fundamental point of view, while their highly-adjustable properties ensure their possible applications in modern opto-electronic devices.  We expect successful production of several novel complex material types including Ge/metal core/shell QDs, continuous 3D nanowire networks and ion-beam induced specific nano-objects in different matrices. We will understand how their optical and electrical properties depend on their structure and how to tailor them to get the desired properties needed for the applications. As the final goal, we will use them to produce energy-efficient greenhouses, highly-efficient electrodes for water splitting and Li-ion batteries, and hydrogen storage reservoirs.  In final, we expect that the proposed investigation will result in findings important for solving current energy-related problems, healthy food production and environment cleaning. We also expect a widening of scientific community interested for these novel material types. These materials and devices have great potential to be mass-produced and applied in modern nanotechnology since magnetron sputtering is the standard industrial technique for glass coating.]]></summary_en></project><project>
<id>7181</id><title_hr><![CDATA[Razumijevanje zračenja na niskim radio frekvencijama: Ususret novoj generaciji radio teleskopa]]></title_hr><title_en><![CDATA[Understanding foreground emission at low radio frequencies: towards the next generations of radio telescopes]]></title_en><user_id>19010</user_id><user_firstLast_name>Vibor Jelić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2018-01</proposal_call><code>IP-2018-01-2889</code><acronim><![CDATA[LowFreqCRO]]></acronim><duration>01.10.2018 - 31.03.2023</duration><status>Završio</status><financ_value>126.482,18 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, </scie_field_hr><scie_field_en>Physics, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>11144, 5738, 25785, 25825, 28978, 864859, </team_members_id><team_members_names><![CDATA[Vernesa Smolcic, Zeljka Marija  Bosnjak, Luka Turić, Bruno Slaus, Ana Erceg, Lana Ceraj Ceraj, ]]></team_members_names><keywords_hr><![CDATA[radioastronomija, polarimetrija, međuzvjezdana materija, magnetska polja, ekstragalaktički radio izvori]]></keywords_hr><keywords_en><![CDATA[radioastronomy, polarimetry, interstellar medium, magnetic fields, extragalactic radio sources]]></keywords_en><summary_hr><![CDATA[Razumijevanje zračenja na niskim radio frekvencijama ključna je za traženje odgovora na brojna temeljna pitanja u astrofizici. Pomoću novih radio teleskopa osjetljivih na radio zračenje niskih radio frekvencija, znanstvenici bi trebali po prvi put detektirati kozmološko zračenje iz perioda nastanka prvih zvijezda u svemiru, staro nekoliko milijardi godina. Ova vrlo duboka opažanja neće samo otkriti kada i gdje su prvi izvori formirani u ranom svemiru započeli ionizirati pretežno neutralnu sve prožimajuću materiju, već će pružiti visoko kvalitetne podatke za najsuvremeniju znanost zračenja iz prednjeg plana. Samo istraživanje fizike zračenja iz prednjeg plana, bilo galaktičkog ili ektragalaktičkog, je zanimljivo samo po sebi i igra ključnu ulogu u razvoju metoda za eliminaciju zračenja iz prednjeg plana u kozmološkim eksperimentima. Ovdje predlažemo najsuvremenije istraživanje zračenja iz prednjeg plana. Konkretnije, mi ćemo: (i) koristiti radio teleskopa LOFAR za detaljnu tomografiju (lokalne) međuzvjezdane materije (ISM) pomoću opažanja sinhrotronskog zračenja naše galaksije i njegove polarizacije; (ii) kombinirati radio-opažanja s drugim promatranjima (npr. HI, H?, prašina, GRB, zvijezde itd.) kako bi istražili povezanost Faradejevih struktura s ostalim fazama ISMa i njihove povezanost s međuzvjezdanim magnetskim poljima; (iii) izraditi novi model polariziranog zračenja naše Galaksije baziran na LOFARovim promatranjima, a koji će se koristiti za razvoj tehnika uklanjanja zračenja iz prednjeg plana; i (iv) simulacije ekstragalaktičkih radio izvora na temelju rezultata Cosmic Evolution Survey (COSMOS). Financiranje predloženog istraživanja bit će ključno za razvoj    hrvatske astrofizike na međunarodno kompetitivnoj razini, te će rezultati predloženog istraživanja otvoriti put prema ključnim znanstvenim projektima novih generacija radio teleskopa (npr. Square Kilometer Array). ]]></summary_hr><summary_en><![CDATA[Understanding foreground emission at low radio frequencies touches upon many fundamental questions in astrophysics. With the novel low-frequency radio telescopes researchers are expected to detect cosmological radiation emitted billions of years ago, from the time of the first “stars”. These very deep observations will not only set constraints on when and where the first sources formed in the early Universe and began (re)ionizing the predominantly neutral all-pervasive intergalactic medium, but they are also providing high-quality data for cutting edge auxiliary foreground science. Obviously studying the physical origin of the foregrounds, whether Galactic or extragalactic, is a very exciting field in its own right and is of fundamental importance for perfecting the foreground removal techniques in the cosmological experiments. Here, we propose the state-of-the-art study of the foreground emission. In particular, we will: (i) use the novel capabilities of the Low Frequency Array (LOFAR) radio telescope to conduct the detailed tomography of the local interstellar medium (ISM) by observing Galactic synchrotron emission and its polarization; (ii) combine these radio observations with other observational probes (e.g. HI, H?, dust, GRB afterglows, close-by stars, etc.) to investigate the association of Faraday structures with different ISM phases and association with the interstellar magnetic fields; (iii) built new data driven model of Galactic polarized emission that will be used for development of the foreground removal techniques; and (iv) simulations of extragalactic radio sources, based on the Cosmic Evolution Survey (COSMOS) results. Funding of the proposed research is essential to keep Croatian astrophysics at an internationally competitive level and go beyond this by providing results that will pave the way for the key science cases of the next generation of radio telescopes (e.g. Square Kilometer Array). ]]></summary_en></project><project>
<id>7184</id><title_hr><![CDATA[Molekularni aspekti patogenih procesa u AHCY deficijenciji]]></title_hr><title_en><![CDATA[Molecular aspects of disease pathogenesis in AHCY deficiency]]></title_en><user_id>54</user_id><user_firstLast_name>Oliver Vugrek</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2018-01</proposal_call><code>IP-2018-01-5632</code><acronim><![CDATA[MAPinAD]]></acronim><duration>30.04.2019 - 29.10.2023</duration><status>Završio</status><financ_value>130.777,16 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, Kliničke medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, Clinical sciences, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>2896, 19486, 5101, 19242, 23450, 3891, 629, 23732, 23885, 28663, 865294, 866649, </team_members_id><team_members_names><![CDATA[Robert Belužić, Jorge Boucas, Josipa Vlainić, Filip Rokić, Grant Morahan, Kristina Crkvenac Gornik, Marko Marjanović, Darija Mužinić, JONG HOON PARK, Ivana Pavičić, Katrin Nedeljko, Gokhan Dogukan Akarsu, ]]></team_members_names><keywords_hr><![CDATA[Odgovor na oštećenje DNA, adenozin, stanični ciklus, karcinogeneza, bolest jetre, metastaza, transkriptomika]]></keywords_hr><keywords_en><![CDATA[DNA damage response, adenosine, cell cycle, cancerogenesis, liver disease, metastasis, transcriptomics]]></keywords_en><summary_hr><![CDATA[S-adenozilhomocistein hidrolaza (AHCY) katalizira hidrolizu S-adenozilhomocisteina (SAH) na adenozin (Ado) i homocistein (Hcs). Novija istraživanja ukazuju na povezanost AHCY i raka na nekoliko razina: AHCY može regulirati fenotipska obilježja stanica raka; AHCY kao ciljna molekula u terapijskim pristupima te kao biomarker za određena maligna oboljenja. Veza između adenozina (jednog od produkata hidrolize SAH) i raka jednim dijelom je poznata te uključuje stimulaciju proliferacije i ulogu u regulaciji upalnih/imunoloških procesa. Također, aktivnost AHCY u vezi je s razvojem patoloških promjena jetre, što potvrđuje i nedavno objavljen slučaj hepatocelularnog karcinoma kod pacijenta s nedostatnom aktivnošću AHCY.  Naši preliminarni podaci na stanicama hepatocelularnog karcinoma (HepG2) pokazuju da smanjena aktivnost AHCY uzrokuje sniženje razine Ado, uslijed čega dolazi do oštećenja DNA i zastoja u staničnom ciklusu. Iako navedeni podaci pokazuju ulogu AHCY u mehanizmima nastanka malignih oboljenja, točna molekularna podloga te veze nije razjašnjena. Da bismo je razjasnili, koristit ćemo &#39;multi-omics&#39; pristup, uz klasične metode kao što su analiza staničnog ciklusa, proliferacije i oštećenja DNA, na uzorcima tkiva i serumu pacijenata s patološkim promjenama jetre, odabranim staničnim linijama s utišanom ekspresijom AHCY, te na novorazvijenom transgeničnom mišu kao in vivo modelu.  Ispitat će se utjecaj sniženja razina adenozina (kao rezultat smanjene aktivnosti AHCY) na stanični metabolizam te predložiti mehanizam koji povezuje aktivnost AHCY, nastanak oštećenja DNA i regulaciju staničnog ciklusa. Rezultati predloženog istraživanja mogli bi unaprijediti terapijske pristupe u liječenju malignih oboljenja povezanih s smanjenom aktivnošću AHCY, te potaknuti razvoj novih metoda liječenja baziranih na regulaciji pomoću adenozina.]]></summary_hr><summary_en><![CDATA[S-adenosylhomocysteine hydrolase (AHCY) catalyzes the hydrolysis of S-adenosylhomocysteine (SAH) to Adenosine (Ado) and Homocysteine (Hyc). Recently, several studies pointed out connections of AHCY with cancer from various standpoints: as a player that possibly regulates cancer phenotype, as a druggable candidate, or, as a promising biomarker. Metabolome-wise, connections between adenosine and cancer have been established, showing stimulative effects on cell proliferation, and other important roles in inflammation or immunity. Implications of AHCY in hepatic pathology are well documented, and culminated in the recently reported case of hepatocellular carcinoma in an adult with AHCY deficiency. Also, as we have preliminary data showing that low AHCY activity and depletion of adenosine induces DNA damage and cell cycle arrest in hepatocellular carcinoma cells. In summary, involvement of AHCY in molecular mechanisms of cancer is undisputable. However, the molecular basis for the connection between AHCY and cancer is not quite obvious. In order to answers these questions we will deploy a multi-omics approach, in combination with basic molecular and cellular biology procedures focus on the role of AHCY and its mechanism of action on cell cycle, cellular proliferation and DNA damage response in histological and serum samples of liver disease patients, in relevant cancerous and AHCY deficient cell lines, and a unique mouse animal model. In particular, we will investigate the implications of adenosine, besides homocysteine, the primary product of AHCY hydrolytic activity on the cellular metabolism.  By answering these questions we hope to establish the mechanism that connects AHCY activity, DNA damage and regulation of cell cycle through adenosine levels. The outcomes of underlying research may lead to a refinement of therapeutical procedures for cancer as a result of AHCY malfunction, and a potentially new approach for targeted cancer therapy based on adenosine depletion. ]]></summary_en></project><project>
<id>7185</id><title_hr><![CDATA[Sport, diskriminacija i integracija. Sport kao medij društvene inkluzije i participacije]]></title_hr><title_en><![CDATA[Sport, discrimination, and integration. Sport as a vehicle of social inclusion and participation]]></title_en><user_id>19056</user_id><user_firstLast_name>Goran-Pavel Šantek</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2018-01</proposal_call><code>IP-2018-01-2756</code><acronim><![CDATA[INTEGRA]]></acronim><duration>01.01.2019 - 31.12.2022</duration><status>Završio</status><financ_value>79.633,69 eur</financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Etnologija i antropologija, </scie_field_hr><scie_field_en>Ethnology and anthropology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Filozofski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Humanities and Social Sciences]]></institution_en><team_members_id>23670, 19922, 19822, 19921, 19942, 25511, </team_members_id><team_members_names><![CDATA[Rahela Jurković, Anton Vukelić, Tibor Komar, Marijeta Rajković Iveta, Andrew Hodges, Andrej Ivan  Nuredinović , ]]></team_members_names><keywords_hr><![CDATA[Sport, integracija, diskriminacija, inkluzija, participacija]]></keywords_hr><keywords_en><![CDATA[Sport, integration, discrimination, inclusion, participation]]></keywords_en><summary_hr><![CDATA[Pitanje društvene kohezije nerazdvojivo je povezano s problemima integracije i diskriminacije, osobito prema rasi, regionalnoj, etničkoj ili nacionalnoj pripadnosti, ali i svakoj drugoj kulturnoj različitosti.U ovom će se projektu istraživanja provoditi u dva glavna, no međusobno ispreplićuća, istraživačka smjera: a) kroz istraživanja integracije, inkluzije i diskriminacije, kako se u sportu očituju kroz navijače, članove klubova i same sportaše, te b) kroz istraživanja migranata, postmigracijskih procesa i njihova kontekstualiziranja uz sport.Istraživanje se načelno može smjestiti unutar socijalnih koncepata koji razmatraju različite modele povećanja društvene inkluzivnosti i integracije s ciljem promoviranja društveno prihvatljivih obrazaca ponašanja, a sukladno Kevin T. Leichtu (2016). Put ka društvenoj inkluziji koncipiran je stadijima Gorana Therborna (2013).Kroz istraživanje navijača i klupskih članova, ali i migranata u sportu, njihov aktivizam, proteste, peticije, kampanje, radionice, svu javnu verbalnu i vizualnu ekspresiju te druge oblike djelovanja proučit će se njihova samopercepcija i osjećaj,  kako na razini pojedinaca  tako i skupine, diskriminiranosti i marginaliziranosti te kao onih kojima su ugrožena građanska i ljudska prava te kako klubovi djeluju na inkluziju i ekskluziju građana, odnosno kao oruđa društvene kohezije.Očekivani učinak  projekta je doprinos modelima za povećanje inkluzije i umanjenje ekskluzije navijača i migranata putem sporta, odnosno sporta kao oruđa društvene kohezije.Istraživanje će biti zasnovano na različitim praksama kvalitativne i kvantitativne metodologije, posebno na diskurzivnoj analizi, sudioničkom promatranju, etnografskom bilježenju, slobodnim i strukturiranim intervjuima, analizama verbalne i vizualne ekspresije, ali i anketnom upitniku socijalne distance.]]></summary_hr><summary_en><![CDATA[Questions concerning social cohesion are inseparable from those connected with problems of integration and discrimination, especially as regards race, regional, ethnic, sexual or national difference, as well as other kinds of social, cultural and human diversity.Research will be conducted in two main, interrelated research streams: a) through researching integration, inclusion and discrimination as understood by fans, members of clubs and athletes themselves, and b) through researching refugees, migrants, post-migration processes and their contextualising within sport.Such research, according to Leichtu (2016), may be situated inside a framework using social concepts, which consider different models of increasing social inclusion and integration with the aim of promoting socially acceptable patterns of behaviour. The path to social inclusion has been conceived according to Goran Therborne (2013).Fans and/or members of sports’ clubs, but also migrants active in sport, and their self-perceptions and feelings will be studied through their activism, protests, petitions, campaigns, workshops, and through all of their forms of public verbal, visual expression and action. They will be studied both at the individual and group level, including their discrimination and marginalization, and the endangering of their civil and human rights. How clubs work to include and exclude citizens, playing a role as a tool for social cohesion, will also be considered.One of the expected effects from the project is the contribution to models of improvements of fans and migrants’ inclusion and reduction of their exclusion, that is the improvement of sport as a vehicle of social cohesion.Research will be based on various practices of qualitative and quantitative methodology, especially on discursive analysis, participant observation, ethnographic note-taking, free and structured interviews, analysis of verbal and visual expression, but also on poll questionnaire of social distance.]]></summary_en></project><project>
<id>7187</id><title_hr><![CDATA[Kolektivna dinamika u magnetoelektricima]]></title_hr><title_en><![CDATA[Colective Dynamics in Magnetoelectrics]]></title_en><user_id>3184</user_id><user_firstLast_name>Tomislav Ivek</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2018-01</proposal_call><code>IP-2018-01-2730</code><acronim><![CDATA[ColDynaMo]]></acronim><duration>01.10.2018 - 30.09.2023</duration><status>Završio</status><financ_value>132.722,81 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, </scie_field_hr><scie_field_en>Physics, </scie_field_en><institution_hr><![CDATA[Institut za fiziku]]></institution_hr><institution_en><![CDATA[Institute of Physics in Zagreb]]></institution_en><team_members_id>23242, 21233, 12365, 2842, 21185, 11197, 2873, 28904, </team_members_id><team_members_names><![CDATA[Željko Rapljenović, Martina Dragičević, Damir Dominko, Matija Čulo, David Rivas Góngora, Mirta Herak, Nikolina Novosel, Virna Kisiček, ]]></team_members_names><keywords_hr><![CDATA[multiferoik,magnetoelektrik,dielektrik,susceptibilnost,infracrveno,spektroskopija]]></keywords_hr><keywords_en><![CDATA[multiferroic,magnetoelectric,dielectric,susceptibility,infrared,spectroscopy]]></keywords_en><summary_hr><![CDATA[Multiferoični i magnetoelektrični sustavi su novi materijali u fizici čvrstog stanja s izravnom primjenom u industriji visoke tehnologije. Tome svjedoči rastući broj publikacija svake godine u časopisima s visokim faktorom utjecaja. Koristeći zajedno naše kompetitivne i komplementarne eksperimentalne tehnike na Institutu za fiziku u jedinstvenom smo položaju da istražimo ovu široku klasu uzbudljivih materijala. Naš predloženi projekt u skladu je s dva infrastrukturna projekta na Institutu za fiziku: Kriogeni centar Instituta za fiziku - KaCIF i Centar za napredne laserske tehnike - CALT. Sinergija ovog projektnog prijedloga s novim mogućnostima KaCIF-a i CALT-a će dati i nova fundamentalna saznanja o magnetoelektričnom vezanju odgovornom za egzotičnu multiferoičnost. Očekujemo visoki broj publikacija u vrhunskim časopisima iz područja. Ovaj prijedlog je također i platforma za doktorande i poslijedoktorande koji će nam se pridružiti u istraživanju da razviju svoju karijeru. Također planiramo proširiti naše istraživanje slanjem novih projektnih prijedloga na kompetitivne natječaje drugih izvora financiranja.Posebno, namjeravamo istražiti tri grupe multiferoičnih materijala: frustrirane nesumjerljive antiferomagnete, višedomenske magnete s električnom polarizacijom te heksaferite s kemijskom kontrolom svojstava. Cilj je sistematski opisati njihova kolektivna pobiuđenja u sektoru naboja i spina koristeći THz zračenje, magnetska, transportna i dielektrična mjerenja.]]></summary_hr><summary_en><![CDATA[Multiferroics and magnetoelectric systems are novel materials in solid state science with direct application in the high-tech industry. This is evidenced by the growing number of publications in high-impact-factor journals each year. Combining our competitive and complementary experimental techniques at Institute of Physics, we are uniquely positioned to research this broad and exciting class of materials. Our proposed project is in line with two infrastructural projects at our Institute: Cryogenic Centre at the Institute of Physics - KaCIF and Centre for Advanced Laser Techniques - CALT. The synergy of this project proposal with the new possibilities within KaCIF and CALT will result in new fundamental understanding about magnetoelectric coupling ruling a selection of exotic new multiferroics. We expect high publicability in top journals in the field. This proposal is also a platform for doctoral and postdoc students joining us in research to develop their careers. We also plan to extend our research by submitting new proposals to competitive funding calls of other funding agencies.Specifically, we plan to research three groups of multiferroic materials: frustrated incommensurate antiferromagnets, multi-domain magnets with electric polarization as well as chemically-controlled hexaferrites. The aim is to systematically describe their collective excitations in the spin and charge sector using THz radiation, magnetic, transport and dielectric bulk techniques.]]></summary_en></project><project>
<id>7188</id><title_hr><![CDATA[Utjecaj majčinog metaboličkog stanja na serotoninski sustav posteljice i neonatusa: od metilacije DNA do funkcije proteina]]></title_hr><title_en><![CDATA[Influence of maternal metabolic state on placental and neonatal serotonin system: from DNA methylation to protein function]]></title_en><user_id>519</user_id><user_firstLast_name>Jasminka Stefulj</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2018-01</proposal_call><code>IP-2018-01-6547</code><acronim><![CDATA[PLANS]]></acronim><duration>01.12.2018 - 01.06.2023</duration><status>Završio</status><financ_value>131.395,58 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Biologija, </scie_field_hr><scie_field_en>Biology, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>5668, 5996, 5314, 22574, 19949, 12342, 12701, 12354, 23562, 2514, 19126, 21427, 28681, 28959, 861748, 23790, </team_members_id><team_members_names><![CDATA[Lipa Čičin-Šain, Maja Kesic, Dubravka Hranilovic, Barbara Nikolić, Desoye Gernot, Marina Ivanisevic, Josip Juras, Marina Horvatiček, Mirta Starčević, Saša Kralik Oguić, Sandra Nakić Radoš, Maja Anđelinović, Maja Perić, Marina Kukolj, Maja Žutić, Ivona Bečeheli, ]]></team_members_names><keywords_hr><![CDATA[serotonin, posteljica, krv iz pupkovine, metilacija DNA, gestacijski dijabetes]]></keywords_hr><keywords_en><![CDATA[serotonin, placenta, cord blood, DNA methylation, gestational diabetes]]></keywords_en><summary_hr><![CDATA[Serotonin (5HT) je multifunkcionalna signalna molekula, najpoznatija kao neurotransmiter središnjeg živčanog sustava. Osim toga, 5HT igra važne ekstracerebralne uloge, kako u odrasloj dobi tako i tijekom razvoja. Poremećaji 5HT homeostaze povezuju se s mnogim mentalnim zdravstvenim problemima, a pojavljuju se i kao važan čimbenik u pretilosti i dijabetesu. Sve više dokaza sugerira da metilacija DNA modulira ekspresiju 5HT-regulirajućih gena i da može doprinositi  serotoninskoj disfunkciji. Metilacija DNA je dinamičan proces osjetljiv na okolinske utjecaje, posebno tijekom ranog razvoja. Naši nedavni rezultati upućuju da je posteljična metilacija DNA gena za 5HT prijenosnik (SLC6A4), glavni regulator 5HT signalizacije, osjetljiva na majčine metaboličke nepravilnosti povezane s gestacijskim dijabetes melitusom (GDM). Ovaj projekt usmjeren je na daljnje razumijevanje utjecaja majčinog metaboličkog stanja u trudnoći na 5HT sustav posteljice i novorođenčeta. Korištenjem tkiva posteljice i primarnih stanice posteljice dobivenih iz klinički dobro definiranih zdravih i GDM trudnoća, istražit ćemo odnos majčine gestacijske glikemije i predgestacijskog indeksa tjelesne mase (pITM) s posteljičnom metilacijom i ekspresijom gena SLC6A4 i gena za 5HT receptor tipa 2A (HTR2A). Nadalje, studijama in vitro na humanim primarnim trofoblastima istražit ćemo kako izloženost glukozi utječe na metilaciju DNA i ekspresiju gena SLC6A4 te na funkciju odgovarajućeg genskog produkta (aktivnost unosa serotonina). Konačno, istražit ćemo odnos majčine glikemije i pITM s 5HT sustavom novorođenčeta, mjerenjem serotoninskih biokemijskih parametara (razina 5HT, aktivnost 5HT prijenosnika, agregacija trombocita) i metilacije DNA 5HT-regulirajućih gena u krvi iz pupkovine.]]></summary_hr><summary_en><![CDATA[Serotonin (5HT) is a multifunctional signaling molecule, the best known as the central nervous system neurotransmitter. In addition, 5HT plays important extra-cerebral roles, both in adulthood and during development. Disturbances in 5HT homeostasis have been linked to many mental health conditions and are emerging as an important contributor also to obesity and diabetes. Rising evidence suggests that DNA methylation modulates expression of 5HT-regulating genes and may contribute to 5HT dysfunction. DNA methylation is a dynamic process sensitive to environmental influences, particularly during early development. Our recent results suggest that placental DNA methylation of the 5HT transporter gene (SLC6A4), a principal regulator of 5HT signaling, is sensitive to maternal metabolic derangements associated with gestational diabetes mellitus (GDM). This project is aimed to further understand impact of maternal metabolic state in pregnancy on placental and newborn&#39;s 5HT system. Using placental tissue and  primary placental cells obtained from clinically well-defined healthy and GDM pregnancies, we will investigate relationship of maternal gestational glycaemia and pregestational body mass index (pBMI) with placental DNA methylation and expression of SLC6A4 and 5HT receptor type 2A (HTR2A) genes. In addition, by in vitro studies in human primary trophoblasts, we will investigate how exposure to glucose affects SLC6A4 DNA methylation and expression as well as function of the corresponding gene product (serotonin uptake activity). Finally, we will investigate relathionship of meternal glycemia and pBMI with newborn&#39;s 5HT system, by measuring 5HT-related biochemical parameters (5HT levels, platelet 5HT uptake, platelet aggregation) and DNA methylation of 5HT-regulating genes in umbilical cord blood.]]></summary_en></project><project>
<id>7190</id><title_hr><![CDATA[HRVATSKI MONITOR NASILJA - Istraživanje pojavnih oblika, uzroka i procesuiranja delinkventnog nasilja s fokusom na zaštiti posebno ranjivih skupina žrtava]]></title_hr><title_en><![CDATA[]]></title_en><user_id>21439</user_id><user_firstLast_name>Reana Bezic</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-01</proposal_call><code>DOK-2018-01-6494</code><acronim><![CDATA[CroViMo]]></acronim><duration>01.11.2018 - 31.03.2023</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Pravo, </scie_field_hr><scie_field_en>Law, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Pravni fakultet u Zagrebu]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Law]]></institution_en><team_members_id>22461</team_members_id><team_members_names><![CDATA[ Doktorand: Petra Šprem ]]></team_members_names><keywords_hr><![CDATA[kriminologija, nasilje, prevencija nasilja, ubojstvo, kibernetičko uznemiravanje, Hrvatska]]></keywords_hr><keywords_en><![CDATA[criminology, violence, violence prevention, homicide, cyber harassment, Croatia]]></keywords_en><summary_hr><![CDATA[Projekt CroViMo ima za cilj uspostavljanje multidisciplinarne grupe mladih znanstvenika koji će provoditi inovativna istraživanja nasilja u Hrvatskoj kroz svoj „Laboratorij za analizu nasilja“. Glavni cilj istraživanja je empirijsko i normativno snimiti te analizirati fenomenologiju, etiologiju i procesuiranje delinkventnog nasilja u Hrvatskoj, pri čemu će naglasak biti na posebno ranjivim skupinama žrtava sa svojim vrlo specifičnim i različitim potrebama zaštite od nasilja. Te posebno ranjive skupine uključuju: djecu; žene i djevojke; starije; manjine, strance, izbjeglice i migrante; osobe u institucionaliziranoj skrbi; osoblje rizičnih zanimanja; i LGBT. Za razliku od uobičajenog tzv. „mainstream“ istraživanja nasilja, koje se uglavnom fokusira na specifične (pod)vrste nasilja i/ili skupine žrtava izvan općeg konteksta delinkventnog nasilja, CroViMo će prvo provesti izvorno istraživanje ukupnog delinkventnog nasilja, prije no što se fokusira na njegove pojedine (pod)vrste. Ovaj holistički pristup temelji se na pretpostavci da proučavanje određene (pod)vrste nasilja, bez empirijskih podataka o općem nasilnom kontekstu dovodi do fragmentarnih, a potencijalno i iskrivljenih shvaćanja pojedinih promatranih (pod)vrsta nasilja. Glavni zadatak CroViMo biti će razviti i testirati novu inovativnu klasifikaciju delinkventnog nasilja, „autentični sustav klasifikacije nasilja”, koja neće podlijegati normativnim ograničenjima trenutnih klasifikacija, nego će biti usredotočena isključivo na sam fenomen nasilja. Takav sustav klasifikacije mogao bi označiti prekretnicu u području istraživanja nasilja. Ovaj ambiciozni plan rada, ukoliko bi bio uspješno proveden, trebao bi dugoročno osigurati razvoj projekta CroViMo u prepoznatljiv nacionalni, regionalni i europski „Laboratorij za analizu nasilja“, te privući daljnje nacionalne i međunarodne znanstvene suradnje i uspješne nove kolaborativne projektne prijave, s velikim potencijalom za prijenos znanstvenih spoznaja u praksu.]]></summary_hr><summary_en><![CDATA[The CroViMo project aims at setting up a multidisciplinary nationwide research group of young researchers for conducting innovative violence research in Croatia through its&#39; “Violence Research Lab”. The central research objective is to empirically and normatively capture and analyse the phenomenology, etiology, and prosecution of delinquent violence in Croatia, with special focus on particularly vulnerable groups of victims with their very specific and diverse needs for protection from violence. These particularly vulnerable groups include: children; women and girls; the elderly; minorities, foreigners, refugees and migrants; persons in institutional custody; risky professions’ personnel; and LGBT. In contrast to ‘mainstream’ violence research, which predominantly focuses on specific (sub)types of violence and/or victim groups outside the overall context of general delinquent violence, CroViMo will conduct genuine foundational research on the total of delinquent violence, before focusing on its’ certain (sub)types. This broad approach is based on the premise that the study of certain (sub)types of violence without empirical data on the overall violent context leads to fragmentary, and potentially distorted understandings of the (sub)types in question. The main task of CroViMo will be to develop and test an innovative new classification of delinquent violence, the “genuine violence classification system” that will blend out the normative constraints of current mainstream classifications and focus strictly on the violence itself. Such a classification system might be a breakthrough in violence research. This ambitious work plan, if implemented successfully, should in the long run facilitate CroViMo’s development into a recognisable national, regional, and European “Violence Research Lab”, attracting further national and international scientific cooperation and successful joint funding applications, with a huge potential for dissemination of findings into practice.]]></summary_en></project><project>
<id>7192</id><title_hr><![CDATA[Nove primjene 14 MeV neutrona]]></title_hr><title_en><![CDATA[Addvanced applications of 14 MeV neutrons]]></title_en><user_id>1377</user_id><user_firstLast_name>Davorin Sudac</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2018-01</proposal_call><code>IP-2018-01-4060</code><acronim><![CDATA[NeA]]></acronim><duration>01.10.2018 - 31.03.2023</duration><status>Završio</status><financ_value>132.112,28 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, </scie_field_hr><scie_field_en>Physics, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>3983, 4190, 2505, 23275, 23358, 185, 23522, 25523, 28636, 861467, 866585, </team_members_id><team_members_names><![CDATA[Jasmina Obhođaš, Milorad Korolija, Vladivoj Valković, Karlo Nađ, Ilker Meric, Milivoj Uroić, Helge Egil Seime Pettersen, Dubravko Rendić, Martina Pavlovic Pavlovic, Josip Batur, Hadi Shahabinejad, ]]></team_members_names><keywords_hr><![CDATA[neutroni,istraživanje nafte, metan hidrat, rijetke zemlje, standardni materijali, metode detekcije, nove analitičke metode]]></keywords_hr><keywords_en><![CDATA[neutrons, oil logging, methane hydrate, rare earth elements, standard materials, method of detection, new analytical methods]]></keywords_en><summary_hr><![CDATA[Razvit će se metoda primjene brzih pulsiranih neutrona i/ili metode pridružene alfa čestice u istraživanju nalazišta metan hidrata (MH) i elemenata rijetkih zemalja (ERZ). Nalazišta metan hidrata mogu poslužiti kao izvor energije jednako značajan kao i postojeći fosilni izvori energije. Razvit će se metoda pasivnog određivanja koncentracija ERZa pomoću radioaktivnog izotopa 176Lu. Razviti će se kalibracijski postupak za neutronske senzore koji mjere C/O, N/C omjere kao i omjere drugih elemenata od interesa (Al, Si, P, S, Cl, Fe, …). Kako koncentracije elemenata mjerena neutronskim senzorom ovise o okruženju, kalibracijski postupak će se ponoviti za različita tipična okruženja (mineralna, metalna ili organska matrica). Specijalna pažnja posvetiti će se razvoju nove instrumentacije u istraživanju naftnih bušotina (Carbon-to Oxygen oil logging). Cilj istraživanja je razviti metodologiju mjerenja varijacija omjera koncentracija kemijskih elemenata, naročito C/O omjera na maloj skali, što može značajno povećati efikasnost eksploatacije već postojećih naftnih bušotina. Ciljevi istraživanja su:-	Razvoj metoda za ispitivanje podvodnih MH, ERZ i drugih mineralnih nalazišta od interesa-	Razvoj naprednih nuklearnih senzora, naročito za monitoriranje sirove nafte, precizno mjerenja C/O omjera u naftnim bušotinama, uz pomoć najnovijih tehnologija-	Razvoj ‘’ Quality Assurance/Quality Control QA/QC’’ procedure za neutronske sisteme-	Izobrazba mladih istraživača]]></summary_hr><summary_en><![CDATA[Applications of nuclear analytical methods in exploring and monitoring of methane hydrate (MH) and rare earth elements (REE) deposits will be developed by using the pulsed fast neutrons and/or associated alpha particle imaging (API) technique. Methane hydrate deposits can serve as an energy source favorably to the all of the world remaining conventional hydrocarbon sources. A method of passive determination of the REE concentration using a radioactive isotope 176Lu will be developed. The calibration procedures for neutron interrogation systems will be developed for measuring the C/O, N/C ratios and ratios of the other elements of interest (Al, Si, P, S, Cl, Fe, …). Since the concentration values measured by neutron interrogation systems depend on surrounding material too, the calibration procedure will be repeated for different types of surrounding (mineral, metal or organic matrix). Special interest shall be assigned to development of a new instrumentation in Carbon-to-Oxygen (C/O) oil logging. The aim of this research would be the development of a methodology for the measurement of small scale variations in chemical elements concentrations, in particular of C/O ratio, which could significantly increase the exploitation of the existing oil wells.  The specific research objectives are: -	Development of methods for investigation of underwater MH, REE and other mineral deposits of interest;-	Development of advanced nuclear sensors, in particular for crude oil monitoring and for precise C/O logging for very thin layers, coupled with cutting-edge developments in neutron generators, detector technologies, “smart” collimators and analysis techniques.-	Development of the Quality Assurance/Quality Control QA/QC procedures for neutron interrogation systems; -	Hands on training of young researchers.]]></summary_en></project><project>
<id>7197</id><title_hr><![CDATA[Tradicionalizam i inovacije u Dubrovniku  od srednjeg vijeka do devetnaestog stoljeća]]></title_hr><title_en><![CDATA[Traditionalism and Innovation in Dubrovnik  from the Middle Ages until the Nineteenth Century]]></title_en><user_id>739</user_id><user_firstLast_name>Zdenka Janeković Roemer</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2018-01</proposal_call><code>IP-2018-01-5527</code><acronim><![CDATA[INTRADA]]></acronim><duration>01.07.2019 - 30.06.2023</duration><status>Završio</status><financ_value>77.315,02 eur</financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Povijest, </scie_field_hr><scie_field_en>History, </scie_field_en><institution_hr><![CDATA[Hrvatska akademija znanosti i umjetnosti]]></institution_hr><institution_en><![CDATA[Croatian Academy of Sciences and Arts]]></institution_en><team_members_id>458, 386, 481, 398, 726, 389, 430, 1112, 1097, 330, 1078, 23252, 23278, 401, </team_members_id><team_members_names><![CDATA[Stanislava (Slavica) Stojan, Nella Lonza, Vesna Miović, Relja Seferović, Lovro  Kunčević, Rina Kralj-Brassard, Irena Ipšić, Marinko Marić, Kristina Puljizević, Zrinka Pešorda Vardić, Domagoj Madunić, Ariana Violić-Koprivec, Vedran Stojanović, Maja Katušić, ]]></team_members_names><keywords_hr><![CDATA[Dubrovnik, Dubrovačka Republika, tradicionalizam, inovacija, srednji vijek, rani novi vijek]]></keywords_hr><keywords_en><![CDATA[Dubrovnik, Dubrovnik Republic, traditionalism, innovation, Middle ages, Early modern period]]></keywords_en><summary_hr><![CDATA[Polazeći od recentne historiografije posvećene “konstrukcijama” prošlosti, projekt ispituje različite artikulacije tradicionalizma i posljedice tih artikulacija na politiku, društvo i stanovništvo predmodernog Dubrovnika. Tradicionalizam ovdje znači specifičan mentalitet koji prošlost doživljava kao normativnu, odnosno kao ideal za sadašnjost. Cilj projekta je istražiti tradicionalizam predmodernog Dubrovnika kroz koordinirano interdisciplinarno istraživanje sedamnaest povjesničara politike, društva i stanovništva. S obzirom da se tradicionalizam može razumjeti samo kroz međuodnos s inovacijom, projekt se također bavi raznim konceptualizacijama i promicateljima onoga što je smatrano novinom. Predmoderni Dubrovnik je odabran za predmet istraživanja iz dva glavna razloga: radilo se o izrazito tradicionalističkoj sredini koja je iznimno dobro dokumentirana. Sve u svemu, glavni cilj projekta jest: a) rekonstruirati tradicionalističku ideologiju i tradicionalističke povijesne mitove predmodernog Dubrovnika, vezane uz različite aspekte života, od prava preko politike do društvenih običaja; b) analizirati njihove autore (pojedince, skupine, institucije), svrhe i kontekste njihova pojavljivanja; c) rekonstruirati posljedice takvih tradicionalističkih konceptualizacija prošlosti na politiku, društvo i stanovništvo; d) istražiti konceptualizacije i promicatelje inovacije kao i načine na koje je interaktirala s tradicionalizmom.Projekt ima i dva dodatna cilja: prvo, unaprijediti vidljivost hrvatske historiografije kroz diseminaciju rezultata i drugo, unaprijediti istraživačke vještine doktorskih studenata uključenih u istraživački tim.Projekt će rezultirati s najmanje šesnaest izvornih znanstvenih radova, četiri znanstvene monografije, tri radionice i međunarodnom konferencijom.]]></summary_hr><summary_en><![CDATA[Building on the recent historiography on the “construction” of the past, the project investigates various articulations of traditionalism and their effect on the politics, society, and population of pre-modern Dubrovnik. Traditionalism designates a specific mentality which understood the past as being normative, i.e. as representing an ideal for the present. The goal of the project is to investigate Dubrovnik’s traditionalism in the Early modern period through a coordinated interdisciplinary research of seventeen historians of politics, society and population. However, since traditionalism can be understood only through its interplay with innovation, the project also focuses on various conceptualizations and propagators of what was considered to be new. The case-study of premodern Dubrovnik was chosen for two main reasons: it was a strongly traditionalist milieu and, moreover, an excellently documented one. In sum, the main research goal of the project is to: a.) reconstruct the traditionalist ideology and traditionalist historical myths of premodern Dubrovnik regarding the various aspects of life, from law and politics to social customs b.) analyse their creators (individuals, groups, institutions), their purposes, and contexts c.) reconstruct the effect of such traditionalist conceptualizations of the past on politics, society and population d.) investigate the conceptualizations and propagators of innovation as well as the means in which it interacted with traditionalism. The project also has two additional goals: first, improving the visibility of Croatian historiography through the dissemination of the project results; second, improving the research skills of PhD students engaged in the project.The project will result with minimally sixteen research articles, four monographs, three workshops and an international conference. ]]></summary_en></project><project>
<id>7200</id><title_hr><![CDATA[Istraživanje antroponimije na tlu Hrvatske u XV. stoljeću]]></title_hr><title_en><![CDATA[Research of the 15th century anthroponymy on the territory of Croatia]]></title_en><user_id>23405</user_id><user_firstLast_name>Ankica Čilaš Šimpraga</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2018-01</proposal_call><code>IP-2018-01-6053</code><acronim><![CDATA[CroNominaXV]]></acronim><duration>01.10.2018 - 30.09.2022</duration><status>Prekinut</status><financ_value>57.811,37 eur</financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Filologija, </scie_field_hr><scie_field_en>Philology, </scie_field_en><institution_hr><![CDATA[Institut za hrvatski jezik]]></institution_hr><institution_en><![CDATA[Institute of Croatian Language]]></institution_en><team_members_id>19104, 19099, 23406, 6131, 5332, 23460, 818, </team_members_id><team_members_names><![CDATA[Domagoj Vidović, Joža Horvat, Ivan Botica, Dubravka Ivšić Majić, Branimir Brgles, Marijana Belaj, Anđela Frančić, ]]></team_members_names><keywords_hr><![CDATA[antroponimija, antroponomastika, Hrvatska, XV. stoljeće, osobna imena, antroponimijska formula]]></keywords_hr><keywords_en><![CDATA[anthroponymy, anthroponomastics, Croatia, 15th century, personal names, name formula]]></keywords_en><summary_hr><![CDATA[Petnaesto je stoljeće granično razdoblje u hrvatskoj antroponimiji s obzirom na to da od XVI. st., zbog povijesnih prilika, nastaju velike promjene u osobnoimenskome repertoaru i strukturi antroponimijske formule. Temeljni je cilj ovoga projekta stvaranje prve hrvatske antroponomastičke javno dostupne baze podataka te onomastička interpretacija osobnih imena i antroponimijskih formula ekscerpiranih iz reprezentativnih vrela iz XV. stoljeća. S obzirom na to da je osobno ime sociolingvistički znak te da su motivi nastanka i izbora imena ovisni o povijesnim, kulturnim, gospodarskim i političkim prilikama te svjetonazoru i običajima puka, pristup je obradbi antroponimijske građe interdisciplinaran. Zbog toga će u projektnoj skupini uz jezikoslovce surađivati povjesničari te i jedan etnolog. U rad će se uključiti i doktorand kako bi se izgradio mladi znanstvenik specijaliziran za povijesnu antroponomastiku.Antroponimi će se obrađivati u računalnoj bazi u programu Tlex prema metodologiji razvijenoj u dosadašnjim projektima i radovima uključenih suradnika. Dobivena imenska građa omogućit će: (1) analizu strukture antroponimijskih formula u pojedinim hrvatskim krajevima, (2) usporedbu osobnoimenskih repertoara s obzirom na čestoću imena, odnos između imena narodnoga i svetačkoga podrijetla, razlike u nadijevanju imena između seoskih i gradskih sredina te između pripadnika nižih i viših društvenih slojeva te (3) analizu dominantnoga adstratnog jezičnog utjecaja u različitim dijelovima Hrvatske. Jedan je od ciljeva projekta s pomoću interaktivnih zemljovida prikazati: (1) prostiranje najčešćih osobnih imena i (2) distribuciju najčešćih tvorbenih osnova i sufiksa. Rezultati rada na projektu javnosti će biti predstavljeni i kroz znanstvene studije, sudjelovanje na znanstvenim konferencijama i organiziranje znanstvene konferencije posvećene povijesnoj antroponimiji.]]></summary_hr><summary_en><![CDATA[Significant historical changes during the 15th c. influenced significant fractures in Croatian historical anthroponymy. The most notable changes, encountered by the beginning of the 16th c., included considerable transformations in the repertoire of personal names, variations in naming patterns and in the structure of the name formula. Proposed research is focused on excerpting attestations of personal names from selected and highly representative 15th-century sources into a database, which will also include onomastic interpretations and historical context for each name record, and in turn will be publicly available. Keeping in mind that a name is a sociolinguistic sign, and that the motives for its creation are interdependent with historical and cultural circumstances, as well as religious and other popular customs, the research methodology implies an interdisciplinary approach. Therefore the research team includes linguists, historians and an ethnologist, as well as a doctoral student.The database, which will be used to excerpt, document and interpret the attestations of anthroponyms, will be built using Tlex software. The database will enable: 1) analysis of the structure of naming formulas in different regions in the 15th c.; 2) a comparative analysis of the repertoire of personal names with respect to the frequency, relations between “folk” names and the names of the Christian saints, differences in patterns of naming in rural and urban areas and in different social strata; and 3) an analysis of the most common constitutive roots and suffixes. Research goals include the development of digital tools, interactive maps which will visualise: 1) the frequency and extent of most common personal names; 2) the distribution of most common radices and suffixes. The results of the research will be presented to the public through research studies, participation in conferences, and organisation of a conference dedicated to historical anthroponymy.]]></summary_en></project><project>
<id>7204</id><title_hr><![CDATA[Uloga proteina Spartan u DNA replikaciji]]></title_hr><title_en><![CDATA[]]></title_en><user_id>7349</user_id><user_firstLast_name>Ivana Marinović Terzić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-01</proposal_call><code>DOK-2018-01-4568</code><acronim><![CDATA[SprtnRep]]></acronim><duration>01.07.2018 - 24.04.2023</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Splitu, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Split School of Medicine]]></institution_en><team_members_id>25210</team_members_id><team_members_names><![CDATA[ Doktorand: Anja Ančić ]]></team_members_names><keywords_hr><![CDATA[Spartan, DVC1, DNA replikacija, DNA popravak, metaloproteazna domena, hepatocelularni karcinom ]]></keywords_hr><keywords_en><![CDATA[Spartan, DVC1, DNA replication, DNA repair, metalloprotease domain, hepatocellular carcinoma]]></keywords_en><summary_hr><![CDATA[Stabilnost kromosoma tijekom replikacije i popravka DNA je presudna za sprečavanje patološke transformacije stanica. Nedostatnosti DNA popravka uzrokuju razvojne anomalije, preuranjeno starenje (progeriju) i rak. Većina DNA oštećenja blokira napredovanje replikacijske viljuške, jer DNA polimeraza ne može prepoznati oštećene nukleotide. Na takvim mjestima, ubikvitinacija replikacijskog proteina PCNA, koji kao stezaljka kliže po DNA molekuli, pokreće mehanizam  translezijske DNA sinteze (TLS). Nedavno smo identificirali nasljednu mutaciju gena SPRTN (Spartan) kod tri bolesnika, koji su razvili progeroidni sindrom karakteriziran genomskom nestabilnosti i razvojem hepatocelularnog karcinoma (HCC) u mladosti. Druge grupe su pokazale da ja Spartan važan za aktivaciju TLS (Ghosal et al, 2012; Kim i sur, 2013). Naši rezultati pokazuju da Spartan igra važnu ulogu u normalnoj replikaciji DNA, sprečavajući replikacijski stres i održavajući stabilnosti genoma (Marinović-Terzić et al, 2014). U ovom projektu predlažemo da je Spartan metaloproteaza važna za uklanjanje kovalentno vezanih proteina i DNA, čime se omogućava napredovanje replikacijske viljuške.	Cilj ovog projekta je:1. Definirati funkciju Spartan domena,2. Odredite interakcijska svojstva / partnere proteina Spartan3. Opisati dinamiku procesa popravka DNA oštećenja u stanicama bez proteina SpartanVećina tehnika koje ćemo koristiti u ovom radu su uvriježene u našim laboratorijima: Western blot, IP, GST-pulldown, Imunofluorescentna mikroskopija, RNAi, SILAC bazirana masena spektrometrije i protočna citometrija. Koristit ćemo i jednu novu tehniku - CRISPR / Cas9 ciljano preuređivanje gena. Svi pokusi će se raditi na kulturama stanica. Ovaj projekt ima potencijal za generiranje vrlo zanimljivih rezultata i visoku vjerojatnost publiciranja u vrhunskim znanstvenim časopisima. Rezultati ovog projekta će bolje razjasniti specifičnu ulogu proteina Spartan u DNA replikaciji i održavanju genomske stabilnosti.]]></summary_hr><summary_en><![CDATA[The maintenance of chromosomal stability during DNA replication and repair is crucial for preventing patogenic transformation of a cell. Defects in DNA repair cause developmental abnormalities, premature aging, and cancer. Most types of DNA damage block the progression of replication forks, because DNA polymerases cannot recognize damaged nucleotides. At sites of stalled DNA replication fork, replication sliding clamp protein PCNA becomes ubiquitinated and thus initiates translesion DNA synthesis (TLS). Recently, we have identified germline mutations in SPRTN gene (Spartan) in three patients, who developed progeroid syndrome characterized by genomic instability and early onset hepatocellular carcinoma (HCC). Previously it was proposed that Spartan is important for activation of TLS (Ghosal et al, 2012; Kim et al, 2013). Our results show that Spartan plays an essential role in normal DNA replication by preventing DNA replication-stress and maintaining genome stability (Marinovic-Terzic et al, 2014). Here we propose that Spartan is a metaloprotease important for removal of DNA-protein crosslinks, thus enabling the progression of replication forks. Our goal in this project is to:1. Define the functions of Spartan’s domains, 2. Determine Spartans interacting properties/partners, and 3. Describe the dynamics of a DNA damage repair process in Spartan depleted cells. Most of the techniques we will use in this work are established procedures in our laboratories: Western blot, IP, GST-pull down, immunofluorescent microscopy, RNAi, SILAC based mas spectrometry and flow cytometry. One novel technique will be used as well – CRISPR/Cas9 targeted gene editing. All experiments will be performed using cultured cells. This project proposal has a potential to generate very interesting results with high possibility for publications in top scientific journals. Results of this project will help to better understand the specific role of Spartan in DNA replication and genome stability.]]></summary_en></project><project>
<id>7205</id><title_hr><![CDATA[Formalno rasuđivanje i semantike]]></title_hr><title_en><![CDATA[]]></title_en><user_id>21409</user_id><user_firstLast_name>Tin Perkov</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-01</proposal_call><code>DOK-2018-01-6812</code><acronim><![CDATA[FORMALS]]></acronim><duration>12.10.2018 - 12.01.2020</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Matematika, </scie_field_hr><scie_field_en>Mathematics, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Učiteljski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Teacher Education]]></institution_en><team_members_id>23890</team_members_id><team_members_names><![CDATA[ Doktorand: Sebastijan Horvat ]]></team_members_names><keywords_hr><![CDATA[matematička logika, modalna logika, teorija modela, logika u računarstvu, formalno rasuđivanje]]></keywords_hr><keywords_en><![CDATA[mathematical logic, modal logic, model theory, logic in computer science, formal reasoning]]></keywords_en><summary_hr><![CDATA[Projekt će uspostaviti novu istraživačku grupu u području matematičke logike, s ciljem uspostave suradnje među istraživačima čiji dosadašnji rezultati su pretežno teorijski s istraživačima koji su se u dosadašnjem znanstvenom radu fokusirali na primjene. Stoga je naglasak projekta na međusobnoj komunikaciji i diseminaciji, kao i usavršavanju doktoranada koji će se od samog početka znanstvene karijere poticati da razviju ovaj interdisciplinarni pogled. Sadržajno, cilj projekta je međusobno obogaćivanje teorijske i primijenjene logike s naglaskom na primjene logike u računarstvu, ali i obratno, primjene računalnih alata u logičkom i matematičkom istraživanju. Drugi cilj je primjena logike u konkretnim problemima lingvistike ili, općenitije, kognitivnih i informacijskih znanosti, pa i interdisciplinarnih područja u kojima se preklapaju ekonomija i matematika (teorija igara, teorija društvenog izbora). Na prvi pogled vrlo formalna i teorijska disciplina, logika je izrazito primjenjiva, a iznenađuje primjena istih ili sličnih logičkih sistema, osobito modalne logike, u vrlo različitim područjima. Formalizacija donosi pojmovnu preciznost i jasnoću, što omogućuje sigurnost u dokazivanju novih spoznaja, ali i rasvjetljuje kompleksnost problema i otkriva nova pitanja koja u neformalnom rasuđivanju mogu ostati skrivena. Teorijski aspekti projekta obuhvaćaju: 1) istraživanje izražajne snage formalnih jezika metodama teorije modela, 2) adekvatnost i potpunost, odlučivost i složenost logičkih sistema, osobito modalne logike, 3) istraživanje mogućnosti razvoja apstraktne teorije formalnih semantika. Aspekti primjene su: 1) razvoj, istraživanje i formalizacija matematičkih modela za probleme drugih disciplina, 2) razvoj i implementacija algoritama, 3) otkrivanje veza među pitanjima iz prividno različitih područja preko srodnih formalizacija. Projekt predviđa interdisciplinarnu i međunarodnu suradnju.]]></summary_hr><summary_en><![CDATA[A new research group in mathematical logic will be established, with the aim of collaboration between researchers whose previous results were mainly in pure logic and those who previously focused on applications. The emphasis of the project is on mutual communication and dissemination, and training of doctoral students who will be encouraged to develop this interdisciplinary approach from the very beginning of their career. The goal of the project is mutual enrichment of pure and applied logic, with emphasis on applications of logic in computer science, and vice versa, the application of computational tools in logical and mathematical research. Another goal is to apply logic to specific problems of linguistics or, more generally, cognitive and information sciences, as well as interdisciplinary areas in which economics and mathematics overlap (game theory, social choice theory). Even though logic is at the first glance a formal and theoretical discipline, logic is also exceptionally applicable, and it is surprising to see applications of the same or similar formal systems, especially modal logics, in a variety of areas. Formalization brings conceptual precision, clarity and confidence. Formalization also provides new insights of the complexity of problems and allows for discovery of new issues that remain hidden in informal reasoning. The theoretical aspects of the project include: 1) exploring the expressive power of formal languages by methods of model theory, 2) soundness and completeness, decidability and complexity of formal systems, especially modal logics, 3) exploring the possibilities of developing an abstract theory of formal semantics. Application aspects are: 1) development, research and formalization of mathematical models for problems of other disciplines, 2) development and implementation of algorithms, 3) detection of links between seemingly unrelated domains through related formalizations. Interdisciplinary and international collaboration is planned.]]></summary_en></project><project>
<id>7216</id><title_hr><![CDATA[Timska adaptabilnost u razvoju inovativnih proizvoda]]></title_hr><title_en><![CDATA[Team Adaptability for Innovation-Oriented Product Development]]></title_en><user_id>4471</user_id><user_firstLast_name>Mario Štorga</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2018-01</proposal_call><code>IP-2018-01-7269</code><acronim><![CDATA[TAIDE]]></acronim><duration>01.11.2018 - 31.10.2022</duration><status>Završio</status><financ_value>121.441,37 eur</financ_value><scie_area_hr>Tehničke znanosti, Interdiciplinarne znanosti, Društvene znanosti, Prirodne znanosti, Humanističke znanosti, </scie_area_hr><scie_area_en>Technological sciences, Interdisciplinary scientific area, Social sciences, Natural sciences, Humanities, </scie_area_en><scie_field_hr>Interdisciplinarne tehničke znanosti, Matematika, Računarstvo, Strojarstvo, Informacijske znanosti, Kognitivna znanost, Projektni menadžemnt, Interdisciplinarne društvene znanosti, </scie_field_hr><scie_field_en>Interdisciplinary technological sciences, Mathematics, Computer sciences, Mechnical engineering, Information sciences, Cognitive science, Project management, Interdisciplinary social sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet strojarstva i brodogradnje]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Mechanical Engineering and Naval Architecture]]></institution_en><team_members_id>6397, 19022, 17795, 24043, 24142, 24150, 24138, 863804, 27167, </team_members_id><team_members_names><![CDATA[Stanko Škec, Tomislav Martinec, Marija Majda Perišić, Nikola Horvat, John Gero, Peter Törlind, Philip Cash Cash, Fanika Lukačević, Ivan Čeh, ]]></team_members_names><keywords_hr><![CDATA[timski rad, inovativni razvoj proizvoda, adaptabilnost, simulacije, eksprimentalno istraživanje u konstruiranju]]></keywords_hr><keywords_en><![CDATA[teamwork, innovative product development, adaptability, simulation, experimental design research]]></keywords_en><summary_hr><![CDATA[Inženjerski timovi se često koriste u dinamičnom okruženju koje zahtijevaa adaptaciju I promjenu zbog različitih utjecajnih faktora; timovi se moraju prilagoditi promjenama tržišnih trendova, tehnologije ili ograničenjima resursa. Kako se istraživačko područje koje se bavi inženjerskim timovima razvija, istraživanje u ovom području sve više zahtjeva interdisciplinarne pristupe za razumijevanje, modeliranje i unapređenje uloge koje timovi imaju u razvoju proizvoda. S obzirom na to da brojni faktori koji utječu na timski rad ovise o raspoloživom kontekstu aktivnosti, predviđanje performansi timova koji rade licem-u-lice ili u virtualnoj okolini je iznimno zahtjevno, te je očiti nedostatak istraživačkih studija u tom području.Cilj predloženog istraživanja je razvoj istraživačkog i konceptualnog okvira za eksperimentalno istraživanje inženjerskih timova (licem-u-lice kao i u virtualnoj okolini) koji rade na razvoju inovativnih proizvoda. Predloženi projekt će doprinijeti teoriji i praksi kroz interdisciplinarno istraživanje te će se nadograditi na rezultate trenutno aktivnog HRZZ projekta MINMED. Tijekom projekta kao istraživačka metodologija će se koristiti metodologija istraživanja u znanosti o konstruiranju, dok će metode eksperimentalnog istraživanje u konstruiranju biti glavna istraživačka paradigm.Od rezultata projekta se očekuje da ocrtaju kako empirijsko istraživanje i računalne simulacije timskog rada mogu dovesti do boljeg razumijevanja, modeliranja, I unapređenja timska adaptabilnosti kao jednog od glavnih svojstava timskog rada koje je važno za inovativnost. Računalni alati koji će nastati kao rezultat istraživanja trebali bi omogućiti istraživačima te ljudima iz industrije korištenje računalnih simulacija za razumijevanje uloge koju različiti uzroci poremećaja u radu imaju na timsku adaptabilnost.Istraživanje će se izvoditi u multidisciplinarnom okruženju koje uključuje istraživače, ali i istraživačku infrastrukturu u Hrvatskoj, Danskoj, Švedskoj i SAD.]]></summary_hr><summary_en><![CDATA[Engineering teams are often used in dynamic environments that require adaptation and constant change due to external and internal circumstances; they have to adjust to changes in market trends, and adapt to changing technologies or resources constraints. As the research field concerning engineering teams develops, it continues to require interdisciplinary approaches to understand, model and improve the role of the teamwork in product development. However, since there are numerous factors influencing teamwork depend on time and context, understanding and predicting face-to-face and virtual team performance is exceptionally challenging, and there are insufficient research studies.The goal of the proposed research project is the development of the research and conceptualisation framework for experimental studies of engineering teams (both face-to-face and virtual) within innovation-oriented product development projects. The proposed project will contribute to both the theory and practice by bringing together interdisciplinary research and it will build on the results of the ongoing CSF project MINMED. During the project, the Design Science Research framework will be applied as the research methodology, while experimental design research will be the primary research paradigm. The results are expected to delineate how empirical research and computational simulations can lead to better understanding, modelling, reflection on and improvement of team adaptability as one of the most important emergent properties of the engineering teams in relation to innovation. The resulting computational tools should enable researchers and practitioners from the industry to utilise simulations to understand the role that the different types of disruption triggers have on the resulting team adaptation.The research will be conducted by a multidisciplinary research group including the researchers and research infrastructure for experimentation from Croatia, USA, Denmark and Sweden.]]></summary_en></project><project>
<id>7228</id><title_hr><![CDATA[Efikasni algoritmi za robusnu diskretnu optimizaciju]]></title_hr><title_en><![CDATA[Efficient algorithms for robust discrete optimization]]></title_en><user_id>11204</user_id><user_firstLast_name>Robert Manger</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2018-01</proposal_call><code>IP-2018-01-5591</code><acronim><![CDATA[RoDiOpt]]></acronim><duration>22.10.2018 - 21.10.2022</duration><status>Završio</status><financ_value>27.871,79 eur</financ_value><scie_area_hr>Prirodne znanosti, Tehničke znanosti, </scie_area_hr><scie_area_en>Natural sciences, Technological sciences, </scie_area_en><scie_field_hr>Matematika, Računarstvo, </scie_field_hr><scie_field_en>Mathematics, Computer sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>12413, 12411, 23346, 28984, </team_members_id><team_members_names><![CDATA[Goranka Nogo, Krunoslav Puljić, Ana Klobučar, Marko Špoljarec, ]]></team_members_names><keywords_hr><![CDATA[robusna optimizacija, diskretna optimizacija, oblikovanje i analiza algoritama, heuristike, meta-heuristike]]></keywords_hr><keywords_en><![CDATA[robust optimization, discrete optimization, design and analysis of algorithms, heuristics, meta-heuristics]]></keywords_en><summary_hr><![CDATA[Primjerak problema diskretne optimizacije zadaje se točnim vrijednostima parametara unutar njegove funkcije cilja i u njegovim ograničenjima. Te vrijednosti u stvarnom životu obično je teško odrediti – tada govorimo o neizvjesnosti kod formulacije problema.Suvremeni pristup u izlaženju na kraj sa spomenutom neizvjesnošću naziva se robusna optimizacija. U skladu s tim pristupom definira se skup scenarija – svaki od njih zadaje jednu moguću kombinaciju vrijednosti parametara. Promatraju se samo ona rješenja koja su dopustiva za sve scenarije. Na neki se način mjeri ponašanje rješenja ovisno o scenariju. Kao optimalno rješenje u robusnom smislu bira se ono čije je najgore ponašanje, mjereno na cijelom skupu scenarija, najbolje među svim rješenjima.Makar se konvencionalne varijante nekih problema diskretne optimizacije mogu riješiti u polinomijalnom vremenu, robusne varijante istih problema obično su NP-teške. To znači da pronalaženje efikasnih algoritama za robusne varijante predstavlja zanimljivu istraživačku temu. U ovom trenutku nema baš puno algoritama takve vrste koji bi se mogli smatrati prikladnima za primjene u stvarnom životu.Cilj ovog projekta je razviti efikasne i u praktičnom smislu upotrebljive algoritme za robusne varijante sljedećih problema diskretne optimizacije: optimalni putovi u grafovima, optimalni tokovi u mrežama, maksimalni težinski nezavisni skupovi, trgovački putnik i slični problemi. Promatrat će se varijante gdje je skup scenarija konačan i eksplicitno zadan. Naglasak će biti na heurističkim ili meta-heurističkim rješenjima.Svaki od algoritama analizirat će se sa stanovišta korektnosti, preciznosti, odnosno vremenske složenosti. Algoritmi će se implementirati kao softver, vrednovati na velikim primjercima problema te učiniti dostupnima drugim istraživačima preko repozitorija na webu. Postignuti rezultati dokumentirat će se u znanstvenim člancima i objaviti u odgovarajućim časopisima.]]></summary_hr><summary_en><![CDATA[An instance of a discrete optimization problem is specified by exact values of parameters within its objective function and its constraints. In real-world situations parameter values are often hard to determine - then we speak about uncertainty in problem formulation.A state-of-the-art approach to address the mentioned uncertainty is called robust optimization. According to this approach, a set of scenarios is defined - each of them specifies a possible combination of parameter values. Only those solutions are considered that are feasible for all scenarios. The behaviour of any solution under any scenario is measured in some way. As the optimal solution in the robust sense, the one is chosen whose worst behaviour, measured over the whole set of scenarios, turns out to be the best among all solutions.Although conventional variants of some discrete optimization problems can be solved in polynomial time, robust variants of the same problems are usually NP-hard. Consequently, finding efficient algorithms for robust variants is a challenging research topic. At this moment, there are not many algorithms of that kind that can be regarded as suitable for real-world applications.The aim of this project is to develop efficient and practically relevant algorithms for robust variants of the following discrete optimization problems: optimal paths in graphs, optimal flows in networks, maximum weighted independent sets, traveling salesman and similar problems. Variants will be considered where the set of scenarios is finite and given explicitly. Emphasis will be put on heuristic or meta-heuristic solutions.Each algorithm will be analysed in terms of correctness, precision and time complexity. The algorithms will be implemented in software, evaluated on large benchmark problem instances and made available over a web repository to other researchers.  All obtained results will be documented in research papers and published in appropriate journals. ]]></summary_en></project><project>
<id>7229</id><title_hr><![CDATA[Uloga oksidativnog stresa i opiorfina u temporomandibularnim poremećajima]]></title_hr><title_en><![CDATA[]]></title_en><user_id>612</user_id><user_firstLast_name>Iva Alajbeg</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-01</proposal_call><code>DOK-2018-01-5137</code><acronim><![CDATA[ROStrO-TMD]]></acronim><duration>16.07.2018 - 15.10.2020</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Dentalna medicina, </scie_field_hr><scie_field_en>Dental medicine, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Stomatološki fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Dentistry]]></institution_en><team_members_id>21042</team_members_id><team_members_names><![CDATA[ Doktorand: Ema Vrbanović ]]></team_members_names><keywords_hr><![CDATA[temporomandibularni poremećaji, oksidativni stres, opiorfin, orofacijalna bol, ELISA, HPLC MS, slina]]></keywords_hr><keywords_en><![CDATA[temporomandibular disorders, oxidative stress,  opiorphin, orofacial pain, ELISA, HPLC MS, saliva]]></keywords_en><summary_hr><![CDATA[Temporomandibularni poremećaji (TMP) kronični su bolni poremećaji koji zahvaćaju čeljusni zglob, žvačne mišiće i okolna tkiva, s prevalencijom u populaciji od 3,6 do 7%. Patološki supstrat uglavnom izostaje, a uzrok je često nepoznat. Psihološki i mehanički stresni čimbenici mogu doprinijeti nastanku oksidativnog stresa (OS) i rezultirati TMP-om.Cilj je kvantificirati markere OS, totalni antioksidativni kapacitet (TAK) te nedavno izolirani endogeni peptid opiorfin (OP) u slini pacijenata s TMP-om i usporediti ih s kontrolnom skupinom. Kako kronična izloženost stresu može uzrokovati hiperalgeziju koja nastaje kao posljedica odgovora na stres u hipotalamičko-hipofizno-adrenalnoj (HHA) osi, cilj je istražiti ovaj mehanizam uspoređujući OP i markere OS s razinom salivarnog kortizola (SK).Hipoteze: OS ima ulogu u nastanku i održavanju TMP-a, stoga će markeri OS u slini rasti i/ili će se TAK smanjiti; opiorfin utječe na orofacijalne bolne sindrome kao što je TMP i njegove vrijednosti u slini će se razlikovati između bolesnika s TMP-om i kontrole. Poremećena HHA osovina je u podlozi povećanog OS i promjena razina OP u bolesnika s TMP-om.U 50 bolesnika s TMP-om (dijagnosticiranih pomoću kriterija i MRI nalaza) i 50 kontrolnih ispitanika sakupit će se slina. Za određivanje markera OS koristit će se ELISA sa spektrofotometrijom. Razine OP mjerit će se HPLC-MS/MS metodom koju smo sami razvili. Za određivanje SK koristit će se elektrokemiluminiscentna imunokemijska metoda s prethodnom ekstrakcijom.Pacijenti s TMP-om će biti randomizirani u 2 skupine (1:stabilizacijska udlaga + placebo tablete; 2:placebo udlaga + 1g vitamina C). Mjerenja će se ponoviti nakon 3 i 6 mjeseci. Praćenje OP, OS markera i SK tijekom tog razdoblja će, ovisno o promjenama simptoma TMP-a, dodatno rasvijetliti predloženi podliježeći mehanizam. Novi pristup u objašnjavanja neuroendokrinih mehanizama u TMP-u i uporaba sline kao neinvazivno pristupačne dijagnostičke tekućine predstavlja značajan napredak. ]]></summary_hr><summary_en><![CDATA[Temporomandibular disorders (TMD) are chronic painful conditions involving joints, masticatory muscles and associated tissues that affect 3.6-7% of the population. Observable pathology is mostly absent, and the cause is unknown. Psychological and mechanical stress factors could contribute to oxidative stress (OS) and lead to TMD. Aims are to quantify salivary OS markers and total antioxidant capacity (TAC) and to quantify recently isolated endogenous peptide opiorphin (OP) in saliva of TMD patients and compare them to controls. As chronic exposure to stress may cause hyperalgesia as a result of the stress response in the hypothalamic-pituitary-adrenal (HPA) axis, aim is to test this as an underlying mechanism by correlating OP and OS markers to salivary cortisol (SC) levels. Hypotheses: OS has a role in TMD onset and maintenance, thus salivary markers of OS will increase and/or TAC will decrease; OP influences orofacial pain syndromes, such as TMD, and its salivary level will differ between TMD patients and controls. Disbalanced HPA axis underlies the increase of OS and OP level changes in TMD patients.Saliva of 50 TMD patients (diagnosed by validated diagnostic criteria and MRI) and 50 controls will be collected. OS markers will be assessed by ELISA with spectrophotometric detection and by spectrophotometric reagent kits. OP levels will be measured by HPLC-MS/MS method, developed by team members. The electrochemiluminescence immunoassay ECLIA will be used for measuring SC.TMD patients will be randomized in 2 treatment groups (1:stabilization splint + placebo pills; 2:placebo splint + 1g of vitamin C). Measurements will be repeated after 3 and 6 months of treatment. Monitoring of OP, OS markers and SC during that period will, in relation to TMD symptoms changes, further elucidate underlying proposed mechanism.Novel approach to understanding neuroendocrine mechanisms in TMD and use of saliva as non-invasively available biofluid represent significant advances.]]></summary_en></project><project>
<id>7230</id><title_hr><![CDATA[Retrodigitalizacija i interpretacija hrvatskih gramatika do ilirizma]]></title_hr><title_en><![CDATA[Retro-digitization and Interpretation of Croatian Grammar Books before Illyrism]]></title_en><user_id>7861</user_id><user_firstLast_name>Marijana Horvat</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2018-01</proposal_call><code>IP-2018-01-3585</code><acronim><![CDATA[RETROGRAM]]></acronim><duration>25.11.2019 - 24.11.2023</duration><status>Završio</status><financ_value>39.687,57 eur</financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Filologija, Interdisciplinarne humanističke znanosti, </scie_field_hr><scie_field_en>Philology, Interdisciplinary humanities, </scie_field_en><institution_hr><![CDATA[Institut za hrvatski jezik]]></institution_hr><institution_en><![CDATA[Institute of Croatian Language]]></institution_en><team_members_id>12671, 22807, 12754, 23437, 23740, 8629, 12874, 4025, 23565, 23646, </team_members_id><team_members_names><![CDATA[Petra Bago, Ivana  Lovrić Jović, Ana Mihaljević, Sanja Perić Gavrančić, Diana Stolac, Ljiljana  Šarić, Barbara Štebih Golub, Tamara Tvrtković, Ivo Pranjković, Martina Kramarić, ]]></team_members_names><keywords_hr><![CDATA[retrodigitalizacija, digitalna humanistika, hrvatska jezična baština, dopreporodne gramatike, portal hrvatskih gramatika, gramatikografija]]></keywords_hr><keywords_en><![CDATA[retro-digitization, digital humanities network, Croatian linguistic heritage, Pre-standard Croatian Grammars, portal of Croatian grammar books, gramma]]></keywords_en><summary_hr><![CDATA[U Hrvatskoj se tek stvaraju retrodigitalizirani resursi. Ne postoji repozitorij koji bi sadržavao digitalizirane i pretražive stare hrvatske gramatike ni model koji bi se na njih mogao primijeniti, kao ni sustavno provedena istraživanja u tom području. Ovim se projektom namjerava promijeniti takvo stanje. Retrodigitalizacija se odnosi na prijenos tiskanoga medija u računalno čitljiv i pretraživ tekst. Ona u ovom projektu obuhvaća i višerazinsko označivanje transkribiranoga/prevedenoga teksta hrvatskih dopreporodnih gramatika i njihovo povezivanje s faksimilima. Projektom je obuhvaćeno 17 gramatika, štokavskih i kajkavskih, objavljenih do hrvatskoga narodnog preporoda. Priredit će se faksimili svih 17 gramatika. Tekstualnim digitalnim izdanjem bit će predstavljeno 13 gramatika, na kojima će se provoditi kodiranje segmenata gramatičkoga teksta i morfoloških paradigma TEI oznakama, dok će se iz četiriju gramatičkih priručnika samo ispisivati hrvatsko nazivlje. Cilj je izraditi portal hrvatskih gramatika do ilirizma s faksimilima izvornika, metapodatcima i tekstovima transkripcija/prijevoda odabranih gramatika, omogućiti pretraživost na morfološkoj razini, istražiti i opisati gramatike, izraditi indeks hrvatskoga dopreporodnog gramatičkog nazivlja. Planirano je održavanje znanstvenoga skupa o hrvatskoj dopreporodnoj gramatikografiji u europskom kontekstu i objava e-zbornika radova. Projektom se nastoje intenzivirati istraživanja dopreporodne gramatičke građe, upotpuniti spoznaje o morfološkom razvoju hrvatskoga jezika u dopreporodnom razdoblju i spoznaje o razvoju normativnoga opisa te ponuditi znanja primjenom modernih lingvističkih disciplina (kognitivni pristup). Zaključci o izgradnji hrvatskoga gramatičkog modela temeljit će se i na raščlambi strukture latinskih gramatika te će promatrani korpus gramatika predmet interesa usmjeriti i na latinistička istraživanja.Portal bi bio otvorenoga pristupa, zamišljen za trajni daljnji razvoj i rast nakon dovršetka projekta.]]></summary_hr><summary_en><![CDATA[Creation of retro-digitized resources in Croatia is still in beginnings. There is no repository that would contain digitized and searchable database of old Croatian grammars, no model that could be applied, no systematically conducted research in the field. The aim of the proposed project is to change this situation. The retro-digitization implies the transfer of printed media to computer readable and searchable text. It also includes multilevel mark-up of transcribed/translated grammar text and its connection with facsimiles. The project plan covers 17 grammar books published before the Illyrian movement. Grammars will be represented by facsimiles, 13 of them by digital text editions. Digitization process will include mark-up of grammar text segments and morphological paradigms by TEI tags and will be conducted on transcriptions/translations. Four grammars will serve for extraction of linguistic terminology. The main aim of the project is to create a web portal of Croatian grammar books before Illyrism, which would include facsimiles with basic information, transcription/translation, an index of linguistic terminology. The portal will be equipped by thematic searching possibilities on the morphology level. An international scholarly conference on pre-standard Croatian grammaticography in European context is envisaged and online publishing of a conference proceeding on the project web page. The objective is to intensify research activities and interpretation of the Croatian pre-standard grammars within the scope of modern linguistic disciplines (cognitive approach), to complete existing knowledge about the morphological development of the Croatian language, its normative descriptions and developement of linguistic terminology in the pre-standard period. Conclusions on the formation of the Croatian language grammar model will also be based on analysis of the Latin language grammar structure. The result will be an open access web portal available for further upgrade.]]></summary_en></project><project>
<id>7231</id><title_hr><![CDATA[Od površinskih svojstava stanica alga do pokazatelja stresa u vodenim ekosustavima]]></title_hr><title_en><![CDATA[From algal cell surface properties to stress markers for aquatic ecosystems]]></title_en><user_id>513</user_id><user_firstLast_name>Nadica Ivošević DeNardis</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2018-01</proposal_call><code>IP-2018-01-5840</code><acronim><![CDATA[CELLSTRESS]]></acronim><duration>01.12.2018 - 30.11.2022</duration><status>Završio</status><financ_value>116.172,27 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Interdisciplinarne prirodne znanosti, Fizika, Kemija, Biologija, </scie_field_hr><scie_field_en>Interdisciplinary natural sciences, Physics, Chemistry, Biology, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>6101, 19526, 5786, 23474, 23473, 23674, 25737, 17752, </team_members_id><team_members_names><![CDATA[Tea Mišić Radić, Petar Žutinić, Tomislav Vuletić, Joanna Zemła, Malgorzata Lekka, Kobiela Tomasz, Nives Novosel, Maja Levak Zorinc, ]]></team_members_names><keywords_hr><![CDATA[adhezija, AFM, alge, površinska svojstva, salinitet, stanična nanomehanika, stanični stres, temperatura, vodeni ekosustavi]]></keywords_hr><keywords_en><![CDATA[adhesion, AFM, algae, aquatic ecosystems, cell nanomechanics, cell stress, salinity, surface properties, temperature]]></keywords_en><summary_hr><![CDATA[Razumijevanje osjetljivosti različitih trofičkih razina ključno je za predviđanje utjecaja klimatskih promjena na zajednice u vodenom okolišu. CELLSTRESS projekt fokusiran je na morske mikroalge koje imaju ključnu ulogu u globalnoj primarnoj proizvodnji, glavnim biogeokemijskim ciklusima te predstavljaju temelj hranidbenoga lanca u vodenom okolišu. Odgovor stanica alga pouzdan je pokazatelj promjena u ekosustavu budući da zbog kratkoga životnog ciklusa brzo reagiraju na varijacije u okolišu. Cilj projekta je povezivanje staničnoga odgovora alga (u smislu površinskih svojstava i fiziološkoga odgovora) na glavne abiotičke stresore (temperaturu i salinitet) radi boljega razumijevanja preživljavanja i strategija prilagodbi alga u vodenim sustavima. Odabrani modelni organizmi jesu stanice alga različitih svojstava staničnih barijera, pokretljivosti i tolerancije na salinitet. Koristit ćemo komplementarne biofizičke površinske metode utemeljene na analizi pojedinačnih stanica (mikroskopija atomskih sila, kvarcna mikrovaga i elektrokemijska metoda). S obzirom na to da svaka metoda ispituje različite aspekte površinskih svojstava stanica, zajedno mogu pružiti jedinstveno razumijevanje te proširiti skalu karakterizacije stanične površine od mikro do nano razine, što je važno za razumijevanje ponašanja stanica u uvjetima stresa u morskom okolišu. Projekt CELLSTRESS mogao bi znatno doprinijeti sadašnjim spoznajama u biofizici stanica alga na temeljnoj razini. Razumijevanje površinskih svojstava stanica može pomoći u razjašnjavanju međudjelovanja mehanike i biokemije koja regulira funkcionalno ponašanje stanica. Rezultati projekta utjecat će potencijalno na buduće definiranje smjernica za zaštitu okoliša uključivanjem nanomehaničke studije staničnoga stresa u skup metoda za  ocjenu stanja ekosustava koji se proučava.]]></summary_hr><summary_en><![CDATA[A key to forecast the impact of climate change on aquatic communities is an understanding of fragility of different trophic levels in the ecosystem. The CELLSTRESS project focuses on marine microalgae as the globally important primary producers, drivers of essential biogeochemical cycles, as well as the basis of aquatic food web. Changes in algal cell responses can be an accurate marker of ecosystem perturbations, since microalgae quickly respond to subtle environmental variations due to short life cycles. The objective is to relate algal cell response (in terms of surface properties and physiological behaviour) to main abiotic environmental stressors (temperature and salinity) in order to better understand viability and adaptation strategies of algal populations in aquatic systems. Selected model organisms are algal species of varied cellular barrier properties, cell motility and salinity tolerance. We will use complementary biophysical surface methods capable of studying individual cells (atomic force microscopy, quartz crystal microbalance and electrochemical method). While each method probes a different aspect of cell surface properties, together they can provide a more unified understanding and extend the scale of cell surface characterization from micro to nano level, which is of importance to understand cell behaviour under environmental stress conditions. The CELLSTRESS project could substantially contribute to the present knowledge in the biophysics of algal cell on the fundamental level. Understanding of the cell surface properties may help to elucidate the interplay between mechanics and biochemistry that regulates functional cell behaviour. The project results may potentially impact the future environmental protection guidelines by inclusion of nanomechanical cell-stress study in the portfolio of methods to evaluate state of the ecosystem under consideration.]]></summary_en></project><project>
<id>7236</id><title_hr><![CDATA[Mikrolokalni defektni alati u parcijalnim diferencijalnim jednadžbama]]></title_hr><title_en><![CDATA[Microlocal defect tools in partial differential equations]]></title_en><user_id>58</user_id><user_firstLast_name>Nenad Antonić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2018-01</proposal_call><code>IP-2018-01-2449</code><acronim><![CDATA[MiTPDE]]></acronim><duration>01.11.2018 - 15.03.2023</duration><status>Završio</status><financ_value>130.333,80 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Matematika, </scie_field_hr><scie_field_en>Mathematics, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>72, 637, 1460, 17819, 23449, 25426, 864981, 865388, </team_members_id><team_members_names><![CDATA[Marko Erceg, Ivan Ivec, Darko Mitrovic, Andrej Novak, Ivana Vojnović, Matko Grbac, Sandeep Kumar Soni, Milosz Krupski, ]]></team_members_names><keywords_hr><![CDATA[mikrolokalne defektne mjere, H-mjere, H-distribucije, poluklasične mjere, kompaktnost kompenzacijom, zakoni sačuvanja, Friedrichsovi sustavi]]></keywords_hr><keywords_en><![CDATA[microlocal defect measures, H-measures, H-distributions, semiclassical measures, compactness by compensation, conservation laws, Friedrichs system]]></keywords_en><summary_hr><![CDATA[Parcijalne diferencijalne jednadžbe su nesumnjivo jedan od najuspješnijih matematičkih modela za razumijevanje različitih procesa, ne samo u fizici kontinuuma, nego i u drugim znanstvenim i inženjerskim disciplinama. Premda ne postoji opća temeljna teorija parcijalnih diferencijalnih jednadžbi, usvojena je klasa metoda temeljenih na različitim pojmovima slabe konvergencije, koja je primjenjiva na rješavanje širokih klasa parcijalnih diferencijalnih jednadžbi, kao i na proučavanje drugih relevantnih pitanja, bilo intrinsičnih samoj toj teoriji, bilo vezanih uz njezinu primjenu u drugim područjima znanosti i tehnologije. Kompaktnost kompenzacijom i Youngove mjere, razvijeni skoro prije pola stoljeća, su alati razvijeni za bolje razumijevanje što se događa pri prijelazu na limes. Mikrolokalni defektni alati, poput mikrolokalnih defektnih mjera (ili H-mjera), poluklasičnih mjera, jednoskalnih H-mjera, H-distribucija i njihovih inačica, su alati koji se u novije vrijeme razvijaju za istu svrhu. Njihov daljnji razvoj i primjene u području parcijalnih diferencijalnih jednadžbi je glavni cilj istraživanja na ovom projektu. Posebno ćemo proučavati širenje gustoće mikrolokalne energije za neke jednadžbe, kao i dobru postavljenost i numeričko rješavanje heterogenih zakona sačuvanja sa stohastičkom desnom stranom, ili bez nje, za što bi odgovarajuća inačica mikrolokalnog defektnog alata trebala biti konstruirana i primijenjena. Među jednadžbama koje nas zanimaju su i one koje mijenjaju tip (na primjer, zbog visoke heterogenosti permeabilnosti kod prijenosnih procesa), a koje uzrokuju posebne poteškoće. Drugi način proučavanja takvih jednadžbi je njihov zapis u obliku Friedrichsovog sustava, što je klasa sustava prvog reda koja obuhvaća većinu linearnih jednadžbi matematičke fizike, poput klasičnih eliptičkih, paraboličkih i hiperboličkih jednadžbi, ali također i jednadžbe koje mijenjaju tip. Istovremeno, ti sustavi su vrlo pogodni za numeričku analizu.]]></summary_hr><summary_en><![CDATA[Partial differential equations are certainly one of the most successful mathematical models for understanding various processes not only in continuum physics, but in other branches of sciences and engineering. While there is no general core theory of partial differential equations, a class of methods based on various notions of weak convergence has emerged, being applicable for solving large classes of partial differential equations as well as investigating other relevant questions, either intrinsic to this theory, or pertaining to its applications in other fields of science and technology. Compactness by compensation and Young measures were the tools for better understanding of what happens on the limit developed almost half a century ago. Microlocal defect tools, like microlocal defect measures (H-measures), semiclassical measures, one-scale H-measures, H-distributions, and their variants, are the tools being developed recently for the same purpose. Their further development, and applications in the field of partial differential equations is the primal goal of the research within this project. We shall study, in particular, the propagation of microlocal energy density of certain equations, as well as the well-posedness and numerical solutions of heterogeneous conservation laws with or without a stochastic forcing, for which certain variant of microlocal defect tools should be constructed and applied. Among all equations of our interest, there are also equations that change their type (e.g. due to a high heterogeneity of the permeability in transport processes), which cause particular difficulties. Another way to study such equations is by re-writingthem in the form of Friedrichs systems, a class of first order systems which encompasses most of the linear equations of mathematical physics, like classical elliptic, parabolic and hyperbolic equations, but also the equations that change their type. At the same time they are quite convenient for numerical analysis.]]></summary_en></project><project>
<id>7239</id><title_hr><![CDATA[Application of Nanobiotechnology for Nutritional Supplementation with Selenium]]></title_hr><title_en><![CDATA[Primjena nanobiotehnologije za suplementaciju hrane sa selenom]]></title_en><user_id>1258</user_id><user_firstLast_name>Tomislav Vinković</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2018-01</proposal_call><code>IP-2018-01-8119</code><acronim><![CDATA[NutriNTENSe]]></acronim><duration>01.01.2019 - 31.12.2022</duration><status>Završio</status><financ_value>132.576,81 eur</financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Poljoprivreda, Biotehnologija, Interdisciplinarne biotehničke znanosti, </scie_field_hr><scie_field_en>Agriculture, Biotechnology, Interdisciplinary biotechnical sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište Josipa Jurja Strossmayera u Osijeku, Fakultet agrobiotehničkih znanosti Osijek]]></institution_hr><institution_en><![CDATA[Josip Juraj Strossmayer University of Osijek, Faculty of Agrobiotechnical Sciences in Osijek]]></institution_en><team_members_id>3133, 2649, 1390, 21380, 22513, 22492, 23751, 24109, 7747, 26256, 28910, 855872, 858396, 3927, 865170, </team_members_id><team_members_names><![CDATA[Petra Turčić, Blanka Tariba Lovaković, Ana Marija Marjanović, Kristina Radić, Ivna Štolfa Čamagajevac, Ana Vuković, Monika Tkalec, Michalke Bernhard, Zdenko Lončarić, Emerik Galić, Boris Ravnjak, Dejan Bošnjak, Lucija Galić, Dubravka Vitali Čepo, Nikolina Golub, ]]></team_members_names><keywords_hr><![CDATA[selen, biofortifikacija, nanobiotehnologija, povrće, suplementacija hrane, prehrambeni otpad]]></keywords_hr><keywords_en><![CDATA[selenium, biofortification, nanobiotechnology, vegetables, nutritional supplementation, food waste]]></keywords_en><summary_hr><![CDATA[Selen (Se) je bitan mikroelement koji igra važnu ulogu u metabolizmu i mnogim drugim vitalnim funkcijama. Zbog svoje zaštitne aktivnosti tijekom imunološkog odgovora te kod karcinoma, Se se koristi kao dodatak prehrani. Budući da su biljke glavni izvor Se za ljude i životinje, različite strategije poput biofortifikacije i korištenja biljnih ekstrakata se koriste za razvoj prehrambenih dodataka na bazi Se. Biološka raspoloživost selena varira ovisno o nekoliko čimbenika, uključujući kemijski oblik Se, druge hranjive komponente u hrani, fiziološki status i status Se u organizmu. Glavne zapreke u postizanju optimalnog unosa Se su visoko varijabilni sadržaj u različitim vrstama hrane i uska sigurnosna granica unosa različitih Se oblika. Nanotehnologija omogućuje primjenu selenovih nanočestica (SeNPs), koje posjeduju jaču antioksidativnu aktivnost i nižu toksičnost u odnosu na druge oblike Se. NutriNTENSe projekt ima za cilj istražiti djelotvornost i sigurnost inovativnih nutraceutika i funkcionalne hrane na bazi SeNPs primjenom nanobiotehnoloških metoda. To će se postići razvojem dviju inovativnih klasa Se-nutraceutika: funkcionalnog biofortificiranog povrća sa SeNPs (FBVegs) i Se-nanoceutika (SeNCes) korištenjem ekstrakata prehrambenog otpada za biogenu sintezu SeNPs. Oba tipa Se-nutraceutika bit će podvrgnuta in vitro i/ili in vivo ispitivanjima kako bi se istražila njihova biokompatibilnost, sigurnost, farmakokinetička svojstva i farmakološka aktivnost u usporedbi sa selenatom i/ili kemijski sintetiziranim SeNPs. Osim toga, procijeniti će se moguće sinergističko djelovanje biogenih SeNPs i specifičnih bioaktivnih spojeva iz NutriNTENSe biljaka ili ekstrakata. Rezultati dobiveni NutriNTENse projektom biti će od velike koristi za potrošače, poljoprivredne proizvođače i prehrambenu industriju kao krajnje korisnike ishoda projekta. Treba istaknuti da NutriNTENse ima zeleni karakter s ciljem povećanja primjene zdravih i ekološki prihvatljivih proizvoda.]]></summary_hr><summary_en><![CDATA[Selenium (Se) is an essential trace element playing important role in metabolism and many other vital functions. Due to its protective activity in immune response and cancer, it is widely used as a diet supplement. As plants are the main dietary source of Se for humans and animals, different strategies such as biofortification and plant-based extracts are used to develop Se dietary supplements. Selenium bioavailability varies depending on several factors including chemical form of Se, other dietary components, physiological status and selenium status of the organism. The major obstacles in achieving optimal Se intake are highly variable Se content in different food types and narrow safety margin of supplemental Se forms. Nanotechnology enables application of selenium nanoparticles (SeNPs), due to their enhanced antioxidant activities and lower toxicity as compared to other Se forms. NutriNTENSe project aims to investigate the efficacy and safety of innovative SeNPs-based nutraceuticals and functional food using nanobiotechnological tools. This will be achived by following development of two innovative classes of Se-nutraceuticals: functional SeNPs biofortified vegetables (FBVegs) and Se-nanoceuticals (SeNCes) using food waste extracts for biogenic synthesis of SeNPs. Both types of Se-nutraceuticals will be subjected to in vitro and/or in vivo testings to investigate their biocompatibility, safety, pharmacokinetic properties and pharmacological activity compared to selenite and chemically synthesized SeNPs. In addition, possible synergistic action of biogenic SeNPs and specific bioactive compounds found in NutriNTENSe plants and extracts will be evaluated. Results obtained within NutriNTENse will be of great interest for consumers, agricultural producers and food industry as final beneficiaries of project outcomes. It should be highlighted that NutriNTENse is green project aimed to increase implementation of healthy and environment friendly products.]]></summary_en></project><project>
<id>7244</id><title_hr><![CDATA[Od terena do nasada: karakteristike i prilagodljivost na stres prirodnih populacija pitomoga kestena i maruna]]></title_hr><title_en><![CDATA[From field to orchard: wild sweet chestnut populations and marron characteristics and adaptability to stress]]></title_en><user_id>975</user_id><user_firstLast_name>Marilena Idžojtić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2018-01</proposal_call><code>IP-2018-01-1295</code><acronim><![CDATA[CHESTNUT AND MARRON]]></acronim><duration>16.10.2018 - 15.10.2022</duration><status>Završio</status><financ_value>132.722,81 eur</financ_value><scie_area_hr>Biotehničke znanosti, Prirodne znanosti, </scie_area_hr><scie_area_en>Biotechnical sciences, Natural sciences, </scie_area_en><scie_field_hr>Šumarstvo, Biologija, Prehrambena tehnologija, </scie_field_hr><scie_field_en>Forestry, Biology, Food technology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet šumarstva i drvne tehnologije]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Forestry and Wood Technology]]></institution_en><team_members_id>757, 12402, 12710, 12599, 770, 2506, 761, 4570, 27583, 28741, </team_members_id><team_members_names><![CDATA[Igor Poljak, Vibor Roje, Damir Drvodelić, Ivan Perković, Zlatko Liber, Marin Ježić, Mirna  Ćurković Perica, Ines Panjkota Krbavčić, Antonio  Vidaković, Katarina Tumpa, ]]></team_members_names><keywords_hr><![CDATA[pitomi kesten, Castanea sativa, marun, raznolikost, adaptabilnost, epigenetika, rak kestenove kore, Cryphonectria parasitica, otpornost, sjemenske zon]]></keywords_hr><keywords_en><![CDATA[sweet chestnut, Castanea sativa, marron, variability, adaptability, epigenetics, chestnut blight, Cryphonectria parasitica, resistance, seed zones, Cr]]></keywords_en><summary_hr><![CDATA[Pitomi kesten (Castanea sativa Mill.) važana je, široko rasprostranjena, višestruko korisna vrsta drveća u mediteranskom području, od koje se koriste drvo, plodovi, med i tanin. Rak kestenove kore, uzrokovan introducirnom gljivom Cryphonectria parasitica, ugrožava opstanak sastojina pitomog kestena. Glavni cilj ovoga projekta je utvrditi: (1) neutralnu i adaptivnu raznolikost u prirodnim populacijama pitomog kestena u Hrvatskoj iz okolišno različitih staništa; (2) povezanost genetičke strukture, morfološke raznolikosti, kemijske raznolikosti i okolišnih razlika (klimatskih i pedoloških) u prirodnim populacijama i kultivarima pitomog kestena; (3) kvalitetu sjemena i zahtjeve za klijanje sjemena pitomog kestena; (4) genetičku osnovu raznolikosti za adaptivna svojstva na sadnicama uzgojenima u stakleniku i u recipročno-transpantacijskim pokusima; (5) epigenetičke odgovore na sušni stres; (6) tolerantnost selekcioniranih genotipova na patogene; (7) otpornost na patogene sadnica uzgojenih u rasadniku; (8) povezanost između populacijsko-genetičkog pristupa i pokusa u stakleniku kao i recipročno-transplantacijskih pokusa; (9) nastavak dugoročnog praćenja populacija C. parasitica; (10) neutralnu i adaptivnu raznolikost hrvatskih kultivara pitomog kestena; (11) razlike između hrvatskih kultivara pitomog kestena u morfologiji listova i plodova te kemijskom sastavu plodova; (12) razgraničenje sjemenskih zona i izrada smjernica za prijenos sjemena za hrvatske populacije pitomog kestena. Osim doprinosa osnovnim znanstvenim spoznajama o biologiji i ekološkim odnosima pitomog kestena, rezultati ovoga projekta doprinijet će održivom gospodarenju sastojinama pitomog kestena u Hrvatskoj. Rezultati će direktno doprinijeti zaštiti geografskog porijekla maruna, autohtonih hrvatskih kultivara pitomog kestena. Također će biti selekcionirani genotipovi tolerantni na sušni stres kao i oni s većom tolerancijom na biotski stres, odnosno infekciju gljivom Cryphonectria parasitica.]]></summary_hr><summary_en><![CDATA[The sweet chestnut (Castanea sativa Mill.) is a widely spread and important multipurpose tree species in the Mediterranean area, used for its wood, fruit, honey, and tannin. The chestnut blight, caused by the introduced fungus Cryphonectria parasitica, endangers the survival of the sweet chestnut stands. The main goal of this research is to reveal: (1) neutral and adaptive variability in sweet chestnut natural populations from different environmental habitats in Croatia; (2) associations between genetic structure, morphological variation, chemical variation and environmental differences (climatic and soil) in natural populations and in cultivars; (3) sweet chestnut seed quality and germination requirements; (4) genetic basis of variation for adaptive traits on seedlings reared in greenhouse and in reciprocal transplant experiments; (5) epigenetic responses to drought stress; (6) tolerance of selected genotypes to pathogens; (7) resistance to pathogens on seedlings reared in nursery; (8) associations between population genetic approach and greenhouse and reciprocal transplant experiments; (9) continuation of long term monitoring of C. parasitica populations; (10) neutral and adaptive variability in Croatian sweet chestnut cultivars; (11) differences in fruit and leaf morphology and chemical composition of fruits between Croatian marron cultivars; (12) delineation of seed zones and definition of seed transfer guidelines for Croatian sweet chestnut populations. Aside from contribution to the basic scientific knowledge on biology and ecological demands of sweet chestnut, the results will contribute to the sustainable management of sweet chestnut stands in Croatia. Results will contribute directly to the protection of geographic origin of the autochthonous marron cultivars. Croatian sweet chestnut genotypes tolerant to water stress and those with higher tolerance to biotic stress i.e. infection with C. parasitica, will be selected.]]></summary_en></project><project>
<id>7245</id><title_hr><![CDATA[Optimizacijski i statistički modeli i metode prepoznavanja svojstava skupova podataka izmjerenih s pogreškama]]></title_hr><title_en><![CDATA[]]></title_en><user_id>921</user_id><user_firstLast_name>Mirta Benšić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-01</proposal_call><code>DOK-2018-01-6039</code><acronim><![CDATA[OSMoMeSIP]]></acronim><duration>01.07.2018 - 30.06.2022</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Matematika, </scie_field_hr><scie_field_en>Mathematics, </scie_field_en><institution_hr><![CDATA[Sveučilište Josipa Jurja Strossmayera u Osijeku, Fakultet primijenjene matematike i informatike]]></institution_hr><institution_en><![CDATA[Josip Juraj Strossmayer University of Osijek, School of Applied Mathematics and Informatics]]></institution_en><team_members_id>25217</team_members_id><team_members_names><![CDATA[ Doktorand: Una Radojičić ]]></team_members_names><keywords_hr><![CDATA[Optimizacija, Analiza velikih podataka, Grupiranje podataka, Dekonvolucija, Statistički modeli]]></keywords_hr><keywords_en><![CDATA[Optimization, Big data analysis, Data Clustering, Deconvolution, Statistical Models]]></keywords_en><summary_hr><![CDATA[U okviru projekta razmatraju se optimizacijski i statistički aspekti  prepoznavanja svojstava skupova podataka izmjerenih s pogreškama kao sastavni dio atraktivnog i aktivnog područja istraživanja poznatog kao analiza velikih podataka (engl. Big data analysis).  Istraživanja će biti usmjerena na  probleme grupiranja podataka te dekonvolucijske modele i primjene.  Polazi se od pretpostavke da  promatrani skupovi podataka  predstavljaju mjerene vrijednosti varijabli koje se analiziraju, ali u sebi sadrže grešku mjerenja. U velikim skupovima podataka vrlo često je prikladno podatke grupirati na temelju nekih karateristika te modelirati svaku grupu podataka posebnim modelima kojima se opisuju svojstva varijabli kao što su njihov  međusobni odnos, mogućnost separacije, rub skupa vrijednosti varijabli, oblik skupa vrijednosti varijabli, dimenzije (duljinu,  površinu ili volumen) skupa vrijednosti ili općenito vektor parametara kojim su te varijable određene. Problem se u mnogim konkretnim situacijama može formulirati u obliku optimizacijskog problema u kome kriterijska funkcija cilja općenito nije niti konveksna niti diferencijabilna.  U svrhu rješavanja takvih problema razvijat će se efikasne, brze i točne numeričke procedure. Također, zbog postojanja pogreške u podacima, u svrhu razumijevanja i pravilne interpretacije rezultata koristit će se statistički modeli te će se istražiti odgovarajuća statistička svojstva.  ]]></summary_hr><summary_en><![CDATA[As a part of an attractive and active area of research known as big data analysis, optimization and statistical aspects of recognizing data sets properties will be analyzed. Research will be focused on clustering problems, deconvolution models and applications. The assumption is that the observed data sets represent the measured values of the variables to be analyzed but also that they contain a measurement error. In large data sets it is often appropriate to cluster data sets on the basis of certain characteristics and then apply specific models for each group that can describe variable properties such as relationships among them, possibility of separation, edges, specific form of the set of values, dimensions (length, surface or volume) of the set of values or general parameter vector which determines them.  The problem in many practical situations can be formulated as an optimization problem for which the objective function is generally neither differentiable nor convex. In order to solve such problems effectively, rapid and accurate numerical procedures will be developed. Also, due to errors in the data, in order to understand and correctly interpret the results, statistical models will be used and important statistical properties will be characterized. ]]></summary_en></project><project>
<id>7251</id><title_hr><![CDATA[TransCultAA - Transfer of Cultural Objects in the Alpe Adria Region in the 20th century]]></title_hr><title_en><![CDATA[]]></title_en><user_id>402</user_id><user_firstLast_name>Ljerka Dulibić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-01</proposal_call><code>DOK-2018-01-9585</code><acronim><![CDATA[]]></acronim><duration>01.09.2018 - 31.08.2022</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Povijest umjetnosti, </scie_field_hr><scie_field_en>Art history, </scie_field_en><institution_hr><![CDATA[Hrvatska akademija znanosti i umjetnosti]]></institution_hr><institution_en><![CDATA[Croatian Academy of Sciences and Arts]]></institution_en><team_members_id>25208</team_members_id><team_members_names><![CDATA[ Doktorand: Bartol Fabijanić ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>7256</id><title_hr><![CDATA[Disobedient Democracy: A Comparative Analysis of Contentious Politics in European Semi-periphery]]></title_hr><title_en><![CDATA[]]></title_en><user_id>7215</user_id><user_firstLast_name>Danijela Dolenec</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-01</proposal_call><code>DOK-2018-01-4716</code><acronim><![CDATA[]]></acronim><duration>16.10.2018 - 31.12.2022</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Politologija, </scie_field_hr><scie_field_en>Political Science, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet političkih znanosti]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Political Science]]></institution_en><team_members_id>25394</team_members_id><team_members_names><![CDATA[ Doktorand: Maja Gergorić ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>7263</id><title_hr><![CDATA[ROBOCOM++  - Rethinking Robotics for the Robot Companion of the future]]></title_hr><title_en><![CDATA[]]></title_en><user_id>378</user_id><user_firstLast_name>Ivan Petrović</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-01</proposal_call><code>DOK-2018-01-9392</code><acronim><![CDATA[]]></acronim><duration>01.11.2018 - 30.08.2025</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Elektrotehnika, </scie_field_hr><scie_field_en>Electrical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id>22792</team_members_id><team_members_names><![CDATA[ Doktorand: Anđela Čirjak ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>7264</id><title_hr><![CDATA[Doprinos interne komunikacije uspješnosti organizacije: položaj, kanali,  mjerenje i odnos s povezanim konceptima]]></title_hr><title_en><![CDATA[The role of internal communication in an organization: position, channels, measurement and relationship with related concepts]]></title_en><user_id>23352</user_id><user_firstLast_name>Ana Tkalac Verčič</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2018-01</proposal_call><code>IP-2018-01-3323</code><acronim><![CDATA[IntComORG]]></acronim><duration>19.10.2018 - 18.10.2022</duration><status>Završio</status><financ_value>37.082,35 eur</financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Interdisciplinarne društvene znanosti, Ekonomija, Informacijske znanosti, Psihologija, </scie_field_hr><scie_field_en>Interdisciplinary social sciences, Economy, Information sciences, Psychology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Ekonomski fakultet u Zagrebu]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Economics and Business]]></institution_en><team_members_id>19833, 3974, 7317, 23842, 26347, </team_members_id><team_members_names><![CDATA[Dubravka Sinčić Ćorić, Zvonimir Galic, Nina Pološki Vokić, Dijana Najjar, Anja Špoljarić, ]]></team_members_names><keywords_hr><![CDATA[Interna komunikacija, Reputacija, Angažiranost, Marka poslodavca, Psihološki ugovor]]></keywords_hr><keywords_en><![CDATA[Internal communication, Reputation, Engagement, Employer brand, Psychological contract]]></keywords_en><summary_hr><![CDATA[Istraživanja pokazuju kako se svugdje u svijetu povjerenje zaposlenika u vodstvo organizacije smanjuje (Jiang i Probst, 2015; Coats, 2005; Tanner, 2011). Dodatne promjene koje pridonose većoj važnosti interne komunikacije uključuju smanjenja broja zaposlenika,  velike razlike u primanjima prosječnih zaposlenika i vodstva te masovne otkaze i njihov utjecaj na stupanj odanosti zaposlenika (Tkalac Verčič, 2016). Za internu komunikaciju u organizaciji to znači povećanu potrebu za iskrenom dvosmjernom komunikacijom. Globalizacija povećava usredotočenost na internu komunikaciju (Erkkila, 2010) kao i tehnologija koja je ubrzala povezivanje tržišta i organizacija (Mitić, Nikolić, Jankov, Vukonjanski i Terek, 2017). Osnovni cilj ovog projekta je proučavanje, definiranje i povezivanje pojedinih elemenata interne komunikacije s organizacijskom reputacijom putem medijatornih varijabli koje uključuju angažiranost zaposlenika, marku poslodavca, stupanj ispunjenosti psihološkog ugovora i percipiranu organizacijsku podršku. Povezivanje varijabli interne komunikacije s varijablama organizacijske uspješnosti najbolji je način mjerenja i time jasnijeg ustrojavanja funkcije interne komunikacije u organizaciji. Konačna svrha projekta je proširenje i prilagodba definicije interne komunikacije kako bi operacionalizacija precizno i realno odražavala stanje u organizacijskom okruženju; utvrđivanje položaja organizacijskog smještaja interne komunikacije te utvrđivanje mjera uspješnosti interne komunikacije koje se provode u hrvatskim organizacijama. Posebna pažnja biti će posvećena obilježjima internih javnosti, načinima segmentacije, društvenim medijima, angažiranosti zaposlenika, komunikaciji promjena, komunikaciji vodstva i načinima mjerenja i evaluacije. Istraživanje povezanosti zadovoljstva internom komunikacijom i razine angažiranosti zaposlenika značajno je za organizacijsku uspješnost baš kao i istraživanje potencijalne veze s markom poslodavca i reputacijom organizacije. ]]></summary_hr><summary_en><![CDATA[Research shows that all around the world employee trust in organizational leadership is declining (Jiang & Probst, 2015; Coats, 2005; Tanner, 2011). Additional changes that emphasize the significance of internal communication include huge differences in salaries between average employees and top management, mass employee reductions and the effect this has on the level of employee loyalty. For internal communication this means an increased need for open two-way communication. Globalization also increases focus on internal communication (Erkkila, 2010) as well as technology which brings markets and organizations even closer together (Mitić, Nikolić, Jankov, Vukonjanski & Terek, 2017). The main goal of this project is exploring, defining and connecting various elements of internal communication with organizational reputation through mediating variables which include employee engagement, employer brands, psychological contract fulfillment and perceived organizational support. Linking internal communication variables with indicators of organizational success is the best way to measure and establish internal communication as an organizational function. Connecting the level of internal communication satisfaction and the level of employee engagement is important for long term organizational success as is the potential connection with employer brands and organizational reputation.  The final goal of the project is to define internal communication in a way that will realistically and precisely reflect the situation in the organizational environment, to determine the typical position internal communication has in an organization and to define which measures of success are the best for internal communication in organizations. Special attention will be focused on characteristics of internal publics, typical segmentation techniques, social media choices, the level of employee engagement, change communication, leadership communication and measurement and evaluation techniques. ]]></summary_en></project><project>
<id>7268</id><title_hr><![CDATA[Elektroni, kaoni i neutroni u preciznim mjerenjima svojstava hadrona i jezgara]]></title_hr><title_en><![CDATA[Electrons, kaons and neutrons in high precision measurements of hadrons and nuclei properties]]></title_en><user_id>3809</user_id><user_firstLast_name>Damir Bosnar</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2018-01</proposal_call><code>IP-2018-01-8570</code><acronim><![CDATA[EKNpEXP]]></acronim><duration>16.10.2018 - 15.03.2023</duration><status>Završio</status><financ_value>132.391,00 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, </scie_field_hr><scie_field_en>Physics, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>1479, 4413, 24068, 4993, 4909, 4395, </team_members_id><team_members_names><![CDATA[Mihael Makek, Petar Žugec, Darko Mekterović, Catalina Oana Curceanu, Ulrich Müller, Ivica Friščić, ]]></team_members_names><keywords_hr><![CDATA[Elektroni, kaoni, neutroni, hadroni, jezgre,mjerenja]]></keywords_hr><keywords_en><![CDATA[Electrons, kaons,neutrons, hadrons, nuclei, measurements]]></keywords_en><summary_hr><![CDATA[U fokusu su precizna mjerenja u eksperimentima elektronskih raspršenja na nukleonima i jezgrama na MAMI, spektroskopija X-zraka iz prijelaza u kaonskim atomima na DAPHNE i neutronske reakcije na jezgrama na n_TOF postrojenju na CERN-u. Važna komponenta je i razvoj i istraživanje detektora u laboratoriju u Zagrebu za buduće eksperimente.U eksperimentima elektronskih raspršenja elektromagnetski form faktori protona na niskom Q2 će biti određeni uporabom radijacije u početnom stanju kao doprinos pojašnjenju „zagonetke radijusa protona“, neslaganja protonskog radijusa određenog elektronskim i mionskim probama. Precizno određivanje protonskog magnetskog form faktora na višim Q2uporabom Rosenbluthove separacije će osigurati podatke za objašnjenje doprinosa izmjene dva fotona. Električni form faktor će biti mjeren u reakcijama prijenosa polarizacije novim neutronskim detektorom da se smanje sistematske nepouzdanosti. Istraživanja prirode nukleon-nukleon korelacija u jezgri bit će provedeno u eksperimentima s trostrukim koincidencijama. Kaon jezgre interakcije su od velike važnosti za nisko-energijsku QCD. Mjerenja X-zraka iz prijelaza u plinskim kaonskim atomima bit će napravljeno SIDDHARTA-2 detektorom na DAPHNE. Prijelazi u deuteriju su važni, zajedno s rezultatima za vodik, za određivanje isospinski ovisnih antikaon-nukleon duljina raspršenja,  a u heliju za pojašnjenje predloženih duboko vezanih kaonskih nuklearnih stanja. Prijelazi u određenim krutim metama bit će upotrijebljeni za studiju izvodivosti mjerenja mase nabijenog kaona s HPGe detektorom. Analiza podataka sakupljenih u određenim neutronskim reakcijama na n_TOF postrojenju od interesa u astrofizičkim i tehnološkim aplikacijama bit će završena uz znatnu uporabu procedura koje su razvili neki od sudionika projekta.Prototip sustava za detekciju gama zraka baziran na kinematici comptonskog raspršenja za određivanje smjera ulaznih gama zraka bit će sastavljen.    ]]></summary_hr><summary_en><![CDATA[In the focus are high precision measurements in electron scattering experiments on nucleons and nuclei at MAMI, spectroscopy of X-ray transitions in kaonic atoms at DAPHNE and neutron reactions on nuclei at n_TOF facility at CERN. Important component is also detector R&D in laboratory in Zagreb for future experiments.In electron scattering experiments the electromagnetic form factors of the proton at low Q2 using initial state radiation will be determined to contribute to the clarification of the “proton radius puzzle”, disagreement of the proton radius obtained using electron and muon probes. Precise determination of the proton magnetic form factor at higher Q2 by using Rosenbluth separation will provide data for the clarification of two-photon exchange contributions. The neutron electric form factor will be measured in polarization transfer reactions with the new neutron detector to reduce systematic uncertainties. The investigations of the nature of nucleon-nucleon correlations in nuclei will be done in triple coincidence experiments.Kaon-nucleons interactions are of big importance for low-energy QCD. Measurements of X-ray transitions in gaseous kaonic atoms will be done with the SIDDHARTA-2 detector at DAPHNE. Transitions in deuterium are important, with the hydrogen results, for determination of isospin dependent antikaon-nucleon scattering lengths and in helium for the proposed deeply bound kaonic nuclear states. Transitions in selected solid targets will be used for the feasibility study of the measurement of the charged kaon mass with a HPGe detector.Analysis of the data collected in specific neutron reactions on nuclei at n_TOF facility of interest for astrophysics and technological applications will be completed with the strong usage of the procedures developed by some of the project participants.A prototype of gamma detection system based on the kinematics of Compton scattering for the determination of incoming directions of gamma rays will be assembled.]]></summary_en></project><project>
<id>7272</id><title_hr><![CDATA[Mehanizmi nastajanja kalcijevih fosfata na anorganskim nanomaterijalima. Biomimetski put priprave multifunkcionalnih kompozita za regeneraciju čvrstih tkiva]]></title_hr><title_en><![CDATA[Mechanisms of calcium phosphates formation on inorganic nanomaterials. A biomimetic synthetic route for multifunctional nanocomposites for hard tissue regeneration]]></title_en><user_id>224</user_id><user_firstLast_name>Maja Dutour Sikirić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2018-01</proposal_call><code>IP-2018-01-1493</code><acronim><![CDATA[CaPBiomimNanocomp]]></acronim><duration>15.11.2018 - 14.03.2023</duration><status>Završio</status><financ_value>131.966,29 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, Interdisciplinarne prirodne znanosti, </scie_field_hr><scie_field_en>Chemistry, Interdisciplinary natural sciences, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>1069, 339, 423, 4209, 404, 336, 19620, 19592, 28891, 865265, </team_members_id><team_members_names><![CDATA[Atiđa Selmani, Darija Domazet Jurašin, Suzana Šegota, Nadica Maltar Strmečki, Vida Čadež, Tea Mihelj Josipović, Barbara Vuković, Marija Milić, Ina Erceg, Suzana Inkret, ]]></team_members_names><keywords_hr><![CDATA[kalcijevi fosfati, anorganski nanomaterijali, bioaktivne molekule, kompoziti, biomimetski biomaterijali]]></keywords_hr><keywords_en><![CDATA[calcium phosphates, inorganic nanomaterials, bioactive molecules, composites, biomimetic biomaterials]]></keywords_en><summary_hr><![CDATA[Moderni način života i sve dulji životni vijek stanovništva rezultira sve većom učestalošću bolesti čvrstih tkiva (kostiju i zuba). Često je jedini način liječenja takvih oboljenja ugradnja implantata s ciljem regeneracije oboljelog ili oštećenog tkiva. Kako bi se izbjegli problemi vezani uz kvalitetu implantata, intenziviran je razvoj i istraživanje novih, inovativnih implant materijala. Pri tome se posebna pažnja pridaje kompozitnim multifunkcionalnim materijalima, koji osim poboljšanih osteoinduktivnih i mehaničkih svojstava, mogu djelovati i kao lokalni terapijski sustavi za isporuku lijekova. Kako bi takvi materijali bili što funkcinoalniji te kako bi se što više racionalizirao njihov dizajn potrebno je poznavati međudjelovanja komponenti kompozita. To vrlo često nije slučaj pa je pristup dizajnu i sintezi takvih materijala uglavnom empirijski.U posljednje vrijeme kompoziti kalcijevih fosfata (CaP) i anorganskih nanomaterijala (NM) privlače pažnju kao novi, široko primjenjivi materijali za regeneraciju čvrstih tkiva. Cilj predloženog projekta je sustavno istražiti međudjelovanja CaP i dvije vrste nanomaterijala NM, i) NM titanijevog dioksida različite morfologije (nanočestice, nanocjevčice, nanožice, nanopločice) i ii) srebrnih nanočestica različitih površinskih modifikacija, kako bi se utvrdio odnos između površinskih svojstava NM (površinske modifikacije, morfologije, gustoće površinskog naboja, kristalne strukture) i svojstava nastalih CaP u uvjetima bliskim fiziološkim. Također, istražit će se utjecaj albumina i hitosana na nastajanje CaP/NM kompozita, te odrediti potencijal njihove primjene kao materijala za regeneraciju čvrstih tkiva testovima imunokompatibilnosti i hemokompatibilnosti.Predloženi projekt doprinijeti će boljem razumijevanju procesa taloženja na nanopovršinama, što će omogućiti racionalniji pristup ne samo u biomimetskoj sintezi novih biokompozita za regeneraciju čvrstih tkiva, već i u sintezi kompozitnih materijala široke primjene.]]></summary_hr><summary_en><![CDATA[Population ageing and modern lifestyle leads to the increased frequency and consequently growing importance of hard tissues (bone and teeth) diseases. Often the only treatment of such diseases is implantation with the aim to regenerate affected tissue. To prevent failures of the hard tissue implants, new and innovative multifunctional implant materials are sought which, in addition to improved osteoinductive and mechanical properties, will act as local drug delivery system. In this sense, composite materials seems to be materials of choice. In order for these materials to be fully functional and to rationalize their design, the interactions between components should be fully understood. This very often is not the case and success stories are commonly result of empirical not systematic approach. New hard tissue regeneration biomaterials emerging in recent years are composite materials based on calcium phosphates (CaPs) and different inorganic nanomaterials (NMs). The aim of the proposed project is to systematically investigate the CaPs interactions with two types of inorganic NMs; i) titanium dioxide NMs of different morphology (nanoparticles, nanotubes, nanowires, nanoplates) and ii) silver nanoparticles of different surface modifications, in order to determine relationship between NMs interface properties (surface modification, morphology, surface charge density, crystal structure) and the properties of forming CaPs solid phase at conditions close to physiological. In addition, the influence of albumin and chitosan on the formation of CaP/NMs composites will be investigated and potential for their application will be determined using immunocompatibility and hemocompatibility tests. The proposed research will enable a deeper insight into precipitation processes on nanosurfaces, which will provide a rational approach not only in biomimetic synthesis of novel biocomposites for hard tissue regeneration but also in synthesis of materials for different applications.]]></summary_en></project><project>
<id>7274</id><title_hr><![CDATA[Nano-katalizatori aktivirani Sunčevim zračenjem u tehnologijama zaštite okoliša]]></title_hr><title_en><![CDATA[Nano-sized Solar-active Catalysts for Environmental Technologies]]></title_en><user_id>984</user_id><user_firstLast_name>Hrvoje Kušić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2018-01</proposal_call><code>IP-2018-01-1982</code><acronim><![CDATA[NaSCEnT]]></acronim><duration>22.10.2018 - 21.10.2022</duration><status>Završio</status><financ_value>136.392,84 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Kemijsko inženjerstvo, </scie_field_hr><scie_field_en>Chemical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet kemijskog inženjerstva i tehnologije]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Chemical Engineering and Technology]]></institution_en><team_members_id>1122, 3651, 17765, 3845, 3168, 3191, 23523, 25653, 856133, 25650, 25242, 28791, </team_members_id><team_members_names><![CDATA[Ana Lončarić Božić, Marijana Kraljić Roković, Marin Kovačić, Urska Lavrencic Stangar, Panaghiotis Karamanis, Dionysios Dionysiou, Fernando Fresno, Klara Perović, Gabrijela Radić, Josipa Papac, Antonija Tomić, Tayebeh Sharifi, ]]></team_members_names><keywords_hr><![CDATA[solarna fotokataliza, nanokompozitni katalizatori, prioritetna onečišćivala, pročišćavanje vode, proizvodnja vodika]]></keywords_hr><keywords_en><![CDATA[solar photocatalysis, nanocomposite catalysts, priority substances, water purification, hydrogen production]]></keywords_en><summary_hr><![CDATA[Pristup pitkoj vodi i izvorima čiste energije neophodni su za ekonomski razvitak i napredak društva. Međuzavisnost proizvodnje energije i čiste vode dobro je poznata, međutim tehnologije trenutno nisu adekvatno integrirane. Inovativna ideja na kojoj počiva NaSCEnT projekt je dobivanje energije tijekom pročišćavanja vode. Takva hipoteza je utemeljena na istovjetnosti mehanizama koji se odvijaju tijekom fotokatalitičkog pročišćavanja vode te fotoelektrokemijskog cijepanja vode u svrhu dobivanja energije, to jest proizvodnju vodika (H2). Naime, oba procesa se temelje na istom osnovnom mehanizmu koji uključuje generiranje parova elektron/šupljina (e-/h+) na površini poluvodiča uslijed ekscitacije svjetlom, odnosno fotonima odgovarajuće energije. Glavni cilj NaSCEnT projekta je razvoj novog katalitičkog materijala nano-dimenzija (NKM), specifično razvijenog za učinkovito iskorištavanje Sunčeve energije u svrhu pročišćavanja vode i proizvodnje vodika. Sukladno tome, NKM će se pripremiti povezivanjem nanokompozitnih materijala sa poluvodičkim svojstvima na bazi TiO2, uz uključivanje SnS2, BiVO4, i ?-Fe2O3, te grafen oksida različitog stupnja redukcije (GO/rGO). Ciljana onečišćivala na kojima će se primijeniti solar/NKM sustav su farmaceutici, čiji su nusprodukti fotokatalitičke razgradnje niskomolekulske organske tvari koje mogu zamijeniti niskomolekulske alkohole koji se trenutno koriste u procesima fotoelektrokemijskog cijepanja vode. Optimiranje i procjena učinkovitosti solar/NKM sustava, uključujući okolišne, energetske i ekonomske aspekte, biti će provedena integriranjem računalnog i eksperimentalnog pristupa. Učinkovitost NKM-a će biti specifično podešavana kroz planirani dizajn i procedure sinteza, dok će se ugađanje ciljanih svojstava provesti pomoću modeliranja na molekularnoj razini. Rezultati NaSCEnT projekta imat će utjecaj na područja obrade vode i proizvodnje energije, te će utrti put ka primjeni nove, čiste i održive tehnologije.]]></summary_hr><summary_en><![CDATA[Accessible energy resources and clean water are nowadays among the highest priorities sustaining economic growth and societal wellbeing. Although the interdependency of energy and water is well known, the related technologies are still not sufficiently integrated. The groundbreaking idea of NaSCEnT project is to produce the clean energy while cleaning the water thus creating the shift of water-energy nexus paradigm. The underlying mechanism of photocatalytic processes for water purification and photoelectrochemical processes for energy conversion is basically the same. Both H2 production by water splitting and photocatalytic degradation of organic pollutants in water rely on the formation of electron/hole (e-/h+) pairs at a semiconducting material upon its excitation by the light with sufficient photon energy. The main goal of NaSCEnT is to develop novel nano-sized catalyst material (NCM) tailored to effectively harvest solar irradiation for simultaneous solar driven water purification and H2 production. Accordingly, NCM will be prepared by coupling semiconducting composites, made of TiO2 and semiconducting materials (SnS2, BiVO4, and ?-Fe2O3), and graphene oxide and its reduced form (GO/RGO). The NaSCEnT targets treatment of water polluted by pharmaceuticals. Their byproducts, low C-atom species, may mimic the role of lower C-atom alcohols, commonly used in H2 production in sole water splitting. The optimization and evaluation of solar/NCM system effectiveness, comprehending ecological, energetic and economic aspects will be performed integrating modeling and experimental approaches. The performance of NCM will be tailored through the planed design and development procedures. Fine tuning of the particular properties will be assisted by modeling at the molecular scale, thus minimizing the risk of the failure. The NaSCEnT results will address both water and energy fields and pave the way toward the application of innovative, clean and sustainable technologies.]]></summary_en></project><project>
<id>7275</id><title_hr><![CDATA[Utjecaj otvorenih požara na kvalitetu tla i voda]]></title_hr><title_en><![CDATA[Influence of Summer Fire on Soil and Water Quality]]></title_en><user_id>7706</user_id><user_firstLast_name>Ivica Kisić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2018-01</proposal_call><code>IP-2018-01-1645</code><acronim><![CDATA[POP&KTV]]></acronim><duration>01.12.2018 - 30.11.2022</duration><status>Završio</status><financ_value>121.020,64 eur</financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Poljoprivreda, Interdisciplinarne biotehničke znanosti, </scie_field_hr><scie_field_en>Agriculture, Interdisciplinary biotechnical sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Agronomski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Agriculture]]></institution_en><team_members_id>20011, 23536, 19029, 23452, 19879, 19866, 5696, 19016, 19017, 4340, 26199, 28940, 865004, </team_members_id><team_members_names><![CDATA[Igor Bogunović, Marija Ćaćić, Darija Bilandžija, Goran Volf, Nevenka Ožanić, Barbara Karleuša, Željka Zgorelec, Ivana Vitasović Kosić, Aleksandra Perčin, Mak Kišević, Domina Delač, Bojana Horvat, Paulo Pereira, ]]></team_members_names><keywords_hr><![CDATA[erozija tla vodom, degradacija tla,erozija tla vodom, degradacija tla, bioraznolikost, s bioraznolikost, staklenički plinovi, mjere ublažavanja požara]]></keywords_hr><keywords_en><![CDATA[water erosion, soil degradation, water pollution, biodiversity, greenhouse gases, mitigation of summer fire]]></keywords_en><summary_hr><![CDATA[Požari otvorenoga prostora predstavljaju prirodnu katastrofu za cijeli prostor Republike Hrvatske, a osobito za Mediteranski dio RH. Dosadašnja iskustva pokazala su da je većina požara otvorenoga prostora inicirana paljenjem vatre na napuštenom poljoprivrednom zemljištu (Obad, 1990; Defilippis, 1997; Nodilo, 2003; Mamut, 2011; Matas, 2015). U posljednjih četrdesetak godina zabilježen je izraziti porast otvorenih požara. U razdoblju od 2006. do 2015. godine u prosjeku je u RH bilo godišnje 2541 otvoreni požar, a tijekom 2017. godine do kraja listopada zabilježen je najveći broj otvorenih požara – 4248. Jedna od najvećih posljedica otvorenih požara je povećanje erozijskih procesa što uzrokuje smanjenje kvalitete tla, onečišćenje voda, povećanje emisije stakleničkih plinova te smanjenje bioraznolikosti. Utjecaj požara na okoliš bi se u okviru ovoga projekta istraživao na nekoliko lokacija u Zadarskoj i Šibensko kninskoj županiji, ovisno o veličini i lokaciji požara. Požar bi morao biti u blizini otvorena vodotoka (rijeka Krka) ili jezera (Vransko jezero). Cilj istraživanja je kvantificirati posljedice po okoliš istraživanih požara; koliko požari uzrokuju degradaciju tla i onečišćenje voda, koliko povećavaju emisiju stakleničkih plinova, te kako utječu na obnovu vegetacije.Istraživanje bi uključivalo prikaz promjena meteoroloških pojava na prostoru Zadra i Šibenika tijekom zadnjih pedeset godina, te bi se temeljem podataka iz Statističkih ljetopisa i drugih raspoloživih baza, navele postotne promjene u načinu korištenja poljoprivrednih i šumskih površina. Bit će navedene postotne promjene u odnosu urbane i ruralne populacije. Izradila bi se karta erodibilnosti tla za istraživano područje. Opisale bi se posljedice požara na okoliš – utjecaj na izgled krajolika, tlo, vode, bioraznolikost i emisiju stakleničkih plinova. Mjerilo bi se površinsko otjecanje uzrokovano različitim intenzitetom kiše.]]></summary_hr><summary_en><![CDATA[Summer fire represent a natural disaster for the entire territory of the Republic of Croatia, and especially for the Mediterranean part of the Republic of Croatia. Previous experience has shown that most of the summer fire is initiated by burning fire on abandoned agricultural land (Obad, 1990; Defilippis, 1997; Nodilo, 2003; Mamut, 2011; Matas, 2015). Over the last forty years there has been a marked increase in summer fire. In the period from 2006 to 2015, there was an average of  2541 summer fire in Croatia, and during the year 2017, by the end of October, the largest number of summer fire was recorded - 4248. One of the greatest consequences of summer fire is increasing erosion processes thus reducing soil quality, water pollution, increasing greenhouse gas emissions  and biodiversity reduction. The impact of fire on the environment would be within the framework of this project explored at several locations in Zadar and Sibenik-Knin County, depending on the size and location of fire. The fire would have to be near an open watercourse (river Krka) or a lake (lake Vransko). The aim of the study is to quantify the environmental effects of the investigated fires; how  fires cause soil degradation and water pollution, how much they increase greenhouse gas emissions and how they affect the renewal of vegetation. The research would include an overview of the meteorological phenomena occurring in the Zadar and Šibenik areas over the past fifty years, and based on the data from the Statistical Yearbook and other available bases, the percentage changes in the use of agricultural and forest areas would be stated.  A percentage change in relation to the urban and rural population will be listed. A map of soil erodibility for the studied area will be created.  The effects of  fire on the environment will be described - its impact on landscape, soil, water, biodiversity and greenhouse gas emissions. The surface runoff would be measured by different rain intensity. ]]></summary_en></project><project>
<id>7276</id><title_hr><![CDATA[DNA kao dokaz o distribuciji i vitalnosti ugrožene balkanske divokoze]]></title_hr><title_en><![CDATA[]]></title_en><user_id>2954</user_id><user_firstLast_name>Nikica Šprem</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-01</proposal_call><code>DOK-2018-01-4193</code><acronim><![CDATA[BalkCham]]></acronim><duration>02.07.2018 - 01.10.2022</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Poljoprivreda, </scie_field_hr><scie_field_en>Agriculture, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Agronomski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Agriculture]]></institution_en><team_members_id>25111</team_members_id><team_members_names><![CDATA[ Doktorand: Sunčica Stipoljev ]]></team_members_names><keywords_hr><![CDATA[R. rupicapra balcanica, SNP, MHC, efektivna veličina populacije, inbreeding, populacijska struktura, Dinarske planine]]></keywords_hr><keywords_en><![CDATA[R. rupicapra balcanica, SNP, MHC, effective population size,  inbreeding, population structure,Dinaric mountains]]></keywords_en><summary_hr><![CDATA[Model vrsta projektnog prijedloga je balkanska divokoza (R. rupicapra balcanica), populacija sjeverozapadnih Dinarida u Hrvatskoj. Kao karizmatični papkar, balkanska divokoza, vodeća je vrsta kod očuvanja planinskog ekosustava Balkanskog poluotoka koji je jedan od 35 svjetski važnih lokaliteta biološke raznolikosti. Zbog mala veličina populacije i niska genetska varijabilnost populacija divokoza u Dinaridima podložna je mnogim čimbenicima. Sa svim dosadašnjim spoznajama, glavni cilj našeg projekta je analizirati genetsku strukturu balkanske divokoze, koristeći neutralni (SNP) biljeg i biljeg pod selekcijom (MHC kompleks) za procjenu statusa zaštite i proučiti mehanizme molekularne adaptaciji lokalne populacije. Nadalje, ekstrakcija DNA iz lubanja divokoza odstrjeljenih prije reintrodukcije i usporedba uspješnih sekvenci sa današnjim iz genske banke, te potencijalno rekonstruirati filogeografiju divokoza s Velebita. Okolišna i staništa analiza u GIS-u  provest će se analizom prisutnosti i godišnje migracije životinja. Sve to će se postići interdisciplinarnim istraživačkim timom sastavljenim od agronoma, biologa, šumara i veterinara. Rezultati našeg projekta će pružiti uvid u distribuciju i vitalnost, što je važno u uspostavljanju učinkovitog upravljanja buduće populacije divokoza u Dinaridima. Isto tako moramo biti svjesni da je biološka raznolikost kulturna baština stoga nam je dužnost zaštititi balkansku divokozu za buduće generacije.]]></summary_hr><summary_en><![CDATA[The model species of the project proposal is Balkan chamois (R. rupicapra balcanica), specifically population of the northwestern Dinaric Mountains in Croatia. As a charismatic ungulate, Balkan chamois, is an excellent flagship species for the conservation of the montane ecosystems of the Balkan Peninsula which is one of the world’s 35 biodiversity hotspots. The small population size and low genetic variability of the chamois populations in the Dinaric Mountains make them vulnerable to many factors. With all previous findings considered, main goal of our project is to analyse genetic structure of Balkan chamois, using neutral (SNP) and loci under selection (MHC complex) to estimate conservation status and to study mechanisms of molecular adaptation of local populations. Furthermore, DNA extraction from hunted chamois before reintroduction and comparison of successful sequences with contemporary ones from Gen bank, and potential reconstruction of phylogeography of chamois from Velebit Mountain. An environmental and habitat analyses in GIS will carry out to analysis of habitat occupation and annual migration of animals. This will be achieved by interdisciplinary research team composed of agronomist, biologists, forester and veterinarians. Results of our project will provide insights of distribution and vitality, what is important in establishment of the effective future management of chamois population in Dinaric Mountains. Also we must be aware that biodiversity is a cultural heritage and it is important to protect Balkan chamois for future generations.]]></summary_en></project><project>
<id>7278</id><title_hr><![CDATA[Istraživanje složenih multiferoičnih materijala pripravljenih metodama otopinske kemije ]]></title_hr><title_en><![CDATA[]]></title_en><user_id>11136</user_id><user_firstLast_name>Igor Đerđ</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-01</proposal_call><code>DOK-2018-01-1534</code><acronim><![CDATA[SOLFERROMAT]]></acronim><duration>17.07.2018 - 16.07.2022</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, </scie_field_hr><scie_field_en>Physics, </scie_field_en><institution_hr><![CDATA[Sveučilište Josipa Jurja Strossmayera u Osijeku, Odjel za kemiju]]></institution_hr><institution_en><![CDATA[Josip Juraj Strossmayer University of Osijek, Department of Chemistry]]></institution_en><team_members_id>25200</team_members_id><team_members_names><![CDATA[ Doktorand: Jelena Bijelić ]]></team_members_names><keywords_hr><![CDATA[Multiferoici, telurati, volframati, metaloorganske mreže, struktura]]></keywords_hr><keywords_en><![CDATA[Multiferroics, Tellurates, Tungstates, Metal-organic framework, Structure]]></keywords_en><summary_hr><![CDATA[Kako su i feromagnetizam i feroelektricitet ključni u mnogim aspektima moderne tehnologije, zahtjevi za materijalima koji pokazuju oba svojstva predstavljaju značajnu fundamentalnu i tehnološku važnost. Ipak, kad se u jednofaznom materijalu pojavljuje dva ili više fero-uređenja, njihovo međudjelovanje može proizvesti novi učinak koji se manifestira kao električna polarizacija uslijed primjene magnetskoga polja ili, obratno, magnetizacija uslijed primjene električnog polja.Glavni je cilj projekta SOLFERROMAT dizajniranje tri nova tipa funkcionalnih multiferoičnih spojeva: i) metaloorganskih spojeva perovskitne strukture ABX3 (A = amin-kation, B = prijelazni metal, X = organski ligand)ii) hibridne organsko-anorganske perovskitne strukture ABX4 (A = amin-kation, B = prijelazni metal, X = halogeni element) iiii) kompleksnih dvostrukih ili pojedinačnih perovskita tipa A2B(Te/W)O6 ili A3B2(Te/W)O9 (A = laki dvovalentni metal, B = prijelazni metal).Principi moderne koordinacijske kemije koji uključuju sol-gel postupak, mehanokemiju i mehanokemiju potpomognutu otapalom bit će korišteni za dizajniranje novih materijala za pohranu podataka, poglavito za  spintronske uređaje. Pažljivo organizirani slijed sinteza, karakterizacija i mjerenja magnetskih, električnih i magnetoelektričnih svojstava omogućit će postizanje ovoga cilja.Predložena metodologija za karakterizaciju struktura i svojstava novih materijala jest sinergija tehnika korištenih u trima disciplinama: koordinacijskoj kemiji, fizici kondenzirane tvari i znanosti o materijalima.  Glavni je cilj projekta poboljšati istraživanje povezivanjem kristalnog inženjeringa s fizikom i kemijom materijala kako bi se otkrili materijali novih funkcionalnih multiferoičnih svojstava. ]]></summary_hr><summary_en><![CDATA[Since indeed both ferromagnetism and ferroelectricity are essential to many forms of modern technology the demand for materials displaying both properties is of a great fundamental and technological importance, however, when coexistence of two or more ferroic orders in single-phase material is found, and furthermore, intimately coupled, the coupling interaction could produce new effect which manifests itself as an appearance of an electric polarization upon applying a magnetic field, and the appearance of magnetization upon applying an electric field. The main objective of SOLFERROMAT proposal is the design of three novel types of functional multiferroic compounds: i) perovskite structured metal-organic frameworks ABX3 (A = amine cation, B = transition metal, X = organic ligand) ii) perovskite-like hybrid organic-inorganic structures ABX4 (A = amine cation, B= transition metal, X = halogen) and iii) complex double or single perovskites A2B(Te/W)O6 or A3B2(Te/W)O9 (A = light divalent metal, B = transition metal). Building principles of modern coordination chemistry including sol-gel route, mechanochemistry and solvent assisted mechanochemistry will be actively used to explore the fundamental potential of designing new solids for data storage, particularly for spintronic devices. Carefully organized sequence of synthesis, characterization, and magnetic, electric and magnetoelectric properties measurements will allow achieving this goal.The proposed methodology to characterize structure and properties of new materials is the synergy of techniques used in three disciplines: coordination chemistry, condensed matter physics and materials science. The main aim of the project is to enlarge research by introducing crystal engineering into the physics and chemistry of solids, in order to reveal materials with new functional multiferroic properties.]]></summary_en></project><project>
<id>7280</id><title_hr><![CDATA[Kooperativna robotika u nadzoru i istraživanju mora]]></title_hr><title_en><![CDATA[]]></title_en><user_id>5962</user_id><user_firstLast_name>Nikola Mišković</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-01</proposal_call><code>DOK-2018-01-5239</code><acronim><![CDATA[CroMarX]]></acronim><duration>01.11.2018 - 30.06.2021</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Elektrotehnika, </scie_field_hr><scie_field_en>Electrical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id>19973</team_members_id><team_members_names><![CDATA[ Doktorand: Ivan Lončar ]]></team_members_names><keywords_hr><![CDATA[robotika, kooperativna robotika, pomorska robotika, autonomna površinska plovila, autonomna ronilica, višerobotski sustavi]]></keywords_hr><keywords_en><![CDATA[robotics, cooperative robotics, marine robotics, autonomous surface marine vehicles, autonomous underwater vehicle, multi-robot systems]]></keywords_en><summary_hr><![CDATA[Bespilotna plovila (površinska i podvodna) se uspješno koriste za nadzor i istraživanje mora. Ona igraju veliku ulogu u mnogim područjima primjena kao što su morska biologija, morska ekologija, podvodna arheologija, akvakultura, pomorska sigurnost, offshore industrija. Sve pomorske zemlje, kao i Hrvatska koja ima jurisdikciju nad skoro polovicom Jadranskog mora, imaju obavezu nadgledati, istraživati i štititi svoja morska dobra.CroMarX projekt unosi novu dimenziju u nadzor i istraživanje mora uvođenjem kooperativnih plovila koja povećavaju operativnu učinkovitost. Glavni cilj CroMarX projekta je istražiti i razviti kooperativne upravljačke algoritme  u području pomorske robotike, uzimajući u obzir bespilotna površinska plovila (USV, engl. Unmanned Surface marine Vehicles) i bespilotne ronilice (UUV, engl. Unmanned Underwater Vehicles) u svrhu nadzora i istraživanja mora. Prvo, razvit ćemo kooperativne strategije za upravljanje flotom USV-ova kako bi se povećale sposobnosti distribuiranog nadzora mora. Drugo, razvit ćemo upravljačke algoritme koji omogućuju kooperaciju između USV-a i UUV-a, što će značajno povećati istraživačke sposobnosti UUV-ova kroz unaprjeđenje navigacijskih mogućnosti. Treće, razvit ćemo sustav za upravljanje misijama koji će osigurati pregled stanja plovila i imati ulogu korisniku prihvatljivog centra za upravljanje i zadavanje misija pojedinačnom plovilu kao i floti plovila. Na kraju, razvijeni algoritmi će biti eksperimentalno potvrđeni u sklopu tri definirana scenarija: 1) kooperativno upravljanje flotom USV-ova, 2) upravljanje flotom USV-ova koje se adaptira utjecajima iz okoliša, i 3) kooperativno upravljanje između USV-a i UUV-a.]]></summary_hr><summary_en><![CDATA[Unmanned marine vehicles (surface and underwater) are successfully exploited for monitoring and exploring the marine environment. They play a large role in many application fields such as marine biology, marine ecology, underwater archaeology, aquaculture, marine security, offshore industry. All maritime countries, as well as Croatia with jurisdiction over almost half of the Adriatic Sea, have the obligation to monitor, explore and protect their marine environment.CroMarX project brings a new dimension to marine monitoring and exploration by introducing cooperative marine vehicles that increase operational efficiency. The main objective of the CroMarX project is to investigate and develop cooperative control algorithms in the area of marine robotics, taking into account both unmanned surface marine vehicles (USVs) and an unmanned underwater vehicle (UUV) for the purpose of marine monitoring and exploration. Firstly, we will develop cooperative control strategies for operating a fleet of USVs in order to increase capabilities of distributed marine monitoring operations. Secondly, we will develop control algorithms that allow cooperation between a USV and a UUV, which will significantly enhance exploratory abilities of UUVs by increasing their navigational capabilities. Thirdly, we will develop a mission controller that will ensure situational awareness and act as a user-friendly command and control centre for commanding missions to individual vehicles as well as fleets of vehicles. Finally, the developed algorithms will be experimentally validated within three defined scenarios: 1) cooperative control of a fleet of USVs, 2) environmentally adaptive control of a fleet of USVs, and 3) cooperative control between a USV and a UUV. ]]></summary_en></project><project>
<id>7283</id><title_hr><![CDATA[Cas3 kao kontrolna točka obrane CRISPR-Cas: razjašnjenje  njegove regulacije istraživanjem stabilnosti proteina i prepisivanja u bakteriji Escherichia coli]]></title_hr><title_en><![CDATA[]]></title_en><user_id>4503</user_id><user_firstLast_name>Ivana Ivančić Baće</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-01</proposal_call><code>DOK-2018-01-8484</code><acronim><![CDATA[Cas3 status]]></acronim><duration>10.10.2018 - 31.12.2022</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Biologija, </scie_field_hr><scie_field_en>Biology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>25303</team_members_id><team_members_names><![CDATA[ Doktorand: Damjan Mitić ]]></team_members_names><keywords_hr><![CDATA[CRISPR-Cas, Cas3, E. coli, RecBCD, HNS]]></keywords_hr><keywords_en><![CDATA[CRISPR-Cas, Cas3, E. coli, RecBCD, HNS]]></keywords_en><summary_hr><![CDATA[Clustered regularly interspaced short palindromic repeats (CRISPR) i CRISPR-associated (Cas) proteini sačinjavaju adaptivni imunološki sustav bakterija i arheja u borbi protiv virusa i plazmida. Ovaj sustav temelji se na ugradnji kratkih fragmenata strane DNA (razmaknice) u regiju CRISPR procesom koji se zove adaptacija. Ugrađene razmaknice služe za pamćenje prethodnih infekcija. U bakteriji Escherichia coli poznata su dva načina adaptacije: naivna i pripremljena. Tijekom naivne adaptacije razmaknice se direktno uzimaju iz strane DNA, dok je u pripremljenoj adaptaciji neophodna već postojeća razmaknica koja stimulira ugradnju novih razmaknica iz iste strane DNA. Za oba načina adaptacije neophodni su proteini Cas1 i Cas2, dok su za pripremljenu adaptaciju još potrebni interferencijski kompleks Cascade i protein Cas3. Unatoč značajnom napretku u otkriću molekularnih mehanizama obrane sustavom CRISPR-Cas, detalji nastanka dvolančanih fragmenata DNA potrebnih za oba načina adaptacije nisu dovoljno poznati, a također je nedovoljno istražena i regulacija CRISPR-Cas interferencije. Za RecBCD smo mi i drugi pokazali da je potreban za pripremu i ugradnju razmaknice u naivnoj adaptaciji, a nedavno smo pokazali da je protein Cas3 ograničavajući faktor CRISPR-Cas interferencije u ovisnosti o temperaturi inkubiranja. To upućuje na mogućnost da postoji još jedna razina regulacije sustava CRISPR-Cas u bakteriji E. coli koju bismo željeli istražiti. Da bismo doznali više o proteinu Cas3, razlozima njegove neobične aktivnosti i ulogama u CRISPR-Cas adaptivnoj imunosti, ciljevi ovog projekta su a) razjasniti je li protein Cas3 reguliran na razini transkripcije i post-translacijski. b) Istražiti uloge proteina Cas3 i komponenti enzima RecBCD u izgradnji CRISPR imunosti (adaptaciji). Također bismo željeli istražiti jesu li uloge ovih proteina međusobno usklađene i povezane s drugim staničnim procesima uključenim u održavanje stabilnosti genoma.]]></summary_hr><summary_en><![CDATA[Clustered regularly interspaced short palindromic repeats (CRISPR) and CRISPR-associated (Cas) proteins constitutes an adaptive immune system in bacteria and archaea against viruses and plasmids. It is based on integration of short fragments of foreign DNA (spacers) into the CRISPR array in a process called adaptation that serves as a memory of prior infections. Two modes of adaptation have been reported in Escherichia coli type IE system: naive and primed. During the naive adaptation, the spacers are directly obtained from a foreign DNA source while in primed adaptation the pre-existing spacer is required to enable enhanced uptake of new spacers from the same foreign DNA. Both modes require Cas1 and Cas2 proteins, and primed adaptation additionally requires interference complex Cascade and Cas3 protein. Despite the significant progress on the molecular mechanisms of defence by the CRISPR-Cas systems, details about generation of DNA fragments needed for both modes of adaptation are not sufficiently known, or mechanisms of the regulation of the CRISPR-Cas interference. We and others have recently shown that RecBCD enzyme is involved in spacer preparation and integration for naive adaptation, and we have very recently shown that Cas3 is the limiting factor for CRISPR-Cas interference depending on the temperature of incubation. This suggests a possibility that additional level of regulation of the CRISPR-Cas interference exists in E. coli. To learn more about the Cas3 protein, explain its unusual activity and find out about its roles in CRISPR-Cas adaptive immunity, the aims of this project are a) to understand if Cas3 is regulated in E. coli transcriptionally and post-translationally. (b) Delineate the roles of RecB and RecBC components of RecBCD and Cas3 protein in building CRISPR immunity (adaptation). We would also like to understand if their roles are coordinated and linked to other host cell genome maintenance processes.]]></summary_en></project><project>
<id>7286</id><title_hr><![CDATA[Utjecaj uključivanja istraživačkih učeničkih pokusa u srednjoškolsku nastavu fizike na razvoj znanstvenog zaključivanja i konceptualnog razumijevanja ]]></title_hr><title_en><![CDATA[Effect of inclusion of students&#39; investigative experiments in secondary school physics teaching on the development of scientific reasoning and conceptual understanding]]></title_en><user_id>23490</user_id><user_firstLast_name>Maja Planinić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2018-01</proposal_call><code>IP-2018-01-9085</code><acronim><![CDATA[INVESTIGATE]]></acronim><duration>22.10.2018 - 21.06.2023</duration><status>Završio</status><financ_value>61.716,11 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Interdisciplinarne prirodne znanosti, Fizika, </scie_field_hr><scie_field_en>Interdisciplinary natural sciences, Physics, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>23541, 23543, 23550, 23643, </team_members_id><team_members_names><![CDATA[Ana Sušac, Karolina Matejak, Lana Ivanjek, Katarina Jeličić, ]]></team_members_names><keywords_hr><![CDATA[nastava fizike, istraživanje, istraživački pokus, znanstveno zaključivanje, konceptualno razumijevanje, valna optika]]></keywords_hr><keywords_en><![CDATA[ physics teaching, inquiry, investigative experiment, scientific reasoning, conceptual understanding, wave optics]]></keywords_en><summary_hr><![CDATA[U Hrvatskoj se trenutno nastoji provesti reforma u nastavi fizike s ciljem promicanja istraživački usmjerene nastave fizike u srednjim školama. Novi bi pristup trebao uključiti mnogo više učeničkih istraživačkih pokusa nego li je sada slučaj. Stoga je važno istražiti učinak njihovog uključivanja, te procijeniti moguće dobrobiti, kao i probleme.  Istraživanje bi se fokusiralo na  valnu optiku, koja se poučava u četvrtom razredu srednje škole (u dobi od 18 – 19 godina).  Postojeća istraživanja već ukazuju na mnoge učeničke konceptualne poteškoće u ovom području i sugeriraju da je ovu temu teško dobro savladati bez pokusa. Nedostatak odgovarajuće eksperimentalne opreme u većini srednjih škola, kao i nedostatak nastavnika fizike s iskustvom u provođenju ovakve nastave,  predstavljaju dodatnu veliku prepreku za uvođenje istraživački usmjerene nastave u hrvatske srednje škole. Cilj bi ovoga projekta  stoga bio osigurati potrebnu opremu, trening i podršku za uključene nastavnike, te tada procijeniti učinak nastavne intervencije na znanstveno zaključivanje i konceptualno razumijevanje valne optike srednjoškolskih učenika. Učeničko znanstveno zaključivanje bilo bi procijenjeno Lawsonovim testom znanstvenog zaključivanja. Za procjenu učeničkog razumijevanja  valne optike bit će razvijen novi instrument (test).  Za razvijanje testa i mjerenje učeničkih sposobnosti i prirasta znanja koristit će se Raschovo modeliranje. Očekivani rezultati projekta uključuju novi dijagnostički test iz valne optike, srednjoškolske istraživački usmjerene nastavne materijale za valnu optiku,  pregled poteškoća hrvatskih učenika  vezanih uz tu temu, te ocjenu učinka istraživačkih pokusa iz valne optike na učeničko znanstveno zaključivanje i konceptualno razumijevanje. ]]></summary_hr><summary_en><![CDATA[The current reform efforts in Croatia in the field of physics teaching are aimed at promoting inquiry –based teaching in Croatian secondary schools. The new approach should include many more investigative students&#39; experiments than is currently the case. It is important to investigate the effects of their inclusion,  and to assess the possible benefits and problems.  The research would be focused on wave optics , which is taught in the fourth year of secondary school (age 18-19 years).  The existing research already points to many student conceptual difficulties, and suggests that this topic is hard to master without experiments. However, the lack of the adequate experimental equipment in most secondary schools,  as well as the lack of physics teachers experienced in this kind of teaching, presents a huge obstacle for the introduction of inquiry-based teaching in Croatian secondary schools.  The aim of this project would therefore be to provide the necessary equipment, training and support for participating teachers, and then to estimate the effect of the teaching intervention on the secondary school students&#39; scientific reasoning and conceptual understanding .  Students&#39; scientific reasoning would be estimated with Lawson&#39;s classroom test of scientific reasoning. For the estimation of students&#39; conceptual understanding of wave optics, a new instrument (test) will be developed.  Rasch modelling will be used for test development and measurement of student abilities and gains. The expected results of the project will include a new diagnostic test in wave optics, an overview of Croatian student difficulties regarding this topic, and an assessment of the effect of investigative experiments in wave optics on students&#39; scientific reasoning and conceptual understanding.  ]]></summary_en></project><project>
<id>7288</id><title_hr><![CDATA[Biološka važnost dipeptidil peptidaze III i njezin utjecaj na zdravlje čovjeka              ]]></title_hr><title_en><![CDATA[Biological relevance of dipeptidyl peptidase III and its impact on human health]]></title_en><user_id>2974</user_id><user_firstLast_name>Sanja Tomić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2018-01</proposal_call><code>IP-2018-01-2936</code><acronim><![CDATA[DPP3BioRe]]></acronim><duration>01.10.2018 - 30.09.2022</duration><status>Završio</status><financ_value>132.722,81 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, Fizika, Biologija, </scie_field_hr><scie_field_en>Chemistry, Physics, Biology, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>2975, 1522, 17312, 4619, 2700, 730, 23593, 11070, 22463, 5071, 1186, 27544, </team_members_id><team_members_names><![CDATA[Antonija Tomić, Zrinka Karačić, Karl  Gruber, Mihaela Matovina, Dejan Agić, Ana Tomašić Paić, Filip Šupljika, Hrvoje Brkić, Sara Matić, Marija Abramić, Ivana Kekez, Antonia Matić, ]]></team_members_names><keywords_hr><![CDATA[metaloenzim, peptidaza, proteinske interakcije, parametri za ion cinka, vezno mjesto, inhibicija, neuropeptidi, DPP III, Keap1-Nrf2 signalni put]]></keywords_hr><keywords_en><![CDATA[metalloenzyme, peptidase, protein interaction, zinc ion parameters, binding site, inhibition, neuropeptides, DPP III, Keap1-Nrf2 signalling pathway]]></keywords_en><summary_hr><![CDATA[Poznato je da ljudska dipeptidil peptidaza III (hDPP III) in vitro katalizira hidrolizu nekih neuropeptida, te da je uključena u stanični odgovor na oksidativni stres preko Keap1-Nrf2 signalnog puta.Cilj predloženog istraživanja je proširiti znanje o biološkom značaju te cink-ovisne egzopeptidaze i njezinom utjecaju na zdravlje čovjeka. Kako bismo postigli zadani cilj, planiramo: (1) razviti nove parametre za ion cinka u proteinima i optimizirati računalne metode u istraživanju strukture metaloenzima, (2) pobliže razjasniti ulogu hDPP III u oksidativnom stresu proučavanjem njenog sudjelovanja u Keap1-Nrf2 signalnom putu, (3) proučiti vezanje nekoliko metalnih dikationa (Zn2+, Cu2+, Mn2+ i Co2+ ) za hDPP III, rasvjetliti mehanizam njihove izmjene i identificirati potencijano inhibitorno vezno mjesto metala, (4) unaprijediti saznanja o prirodnim supstratima ljudske DPP III, te (5) nastojati pronaći nove, moćne inhibitore katalitičke funkcije hDPP III.Novorazvijeni parametri bit će primjenjivi ne samo na hDPP III, već i na druge o cinku ovisne proteine sa sličnim veznim mjestom za metal. Kombinacija računalnog i eksperimentalnog (kinetičkog, spektrometrijskog, strukturalnog i termodinamičkog) pristupa donijet će nova saznanja o protein-protein (hDPP III – Keap1) i protein-ligand (hDPP III – peptidi/inhibitori) interakcijama na molekularnoj razini i njihovoj povezanosti s prijenosom signala u stanici. Ovo istraživanje trebalo bi ponuditi nove smjerove u razvoju farmakoloških spojeva s mogućnošću kontroliranja mehanizama u koje je DPP III uključena.]]></summary_hr><summary_en><![CDATA[It is known that human dipeptidyl peptidase III (hDPP III) cleaves several neuropeptides in vitro, and participates in the cellular oxidative stress response through the involvement in Keap1-Nrf2 signalling pathway. The aim of the proposed research is to advance the knowledge on biological relevance of this zinc dependent exopeptidase and its influence on human health. In order to achieve this, we plan to: (1)  develop new parameters for Zn2+ ion in proteins and optimize the computational approaches in the study of metalloenzyme structure, (2) come closer in understanding the role hDPP III has in the oxidative stress by studying its involvement in the Nrf2-Keap1 signalling pathway, (3) study the binding of several metal dications (Zn2+, Cu2+, Mn2+, and Co2+ ) to hDPP III and mechanism of their exchange, as well as to find the potential inhibitory metal binding site, (4) improve the knowledge on DPP III natural substrates in human, and (5)  search for new, potent inhibitors of the hDPP III catalytic function.The newly developed parameters will be beneficial not only for hDPP III but also for the other zinc dependent proteins with similar metal binding site. The combined computational and experimental (kinetic, spectrometric, structural and thermodynamic) approach should advance the knowledge of the molecular basis of protein-protein (hDPP III – Keap1) and protein-ligand (hDPP III – peptides/inhibitors) interactions and their implications on cell signalling. The study should suggest directions  for the development of pharmacological molecules with potential to control processes in which human DPP III participates.]]></summary_en></project><project>
<id>7289</id><title_hr><![CDATA[Istraživanje granice između neurodegeneracije i neuroregeneracije: identifikacija ključnih molekula pomoću proteomike i funkcionalnih testova na leđnoj moždini sisavaca]]></title_hr><title_en><![CDATA[]]></title_en><user_id>5326</user_id><user_firstLast_name>Miranda Mladinić Pejatović</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-01</proposal_call><code>DOK-2018-01-3087</code><acronim><![CDATA[DefineREgenAgeMode]]></acronim><duration>23.07.2018 - 22.03.2022</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Biologija, </scie_field_hr><scie_field_en>Biology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Fakultet biotehnologije i razvoja lijekova]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Biotechnology and Drug Development]]></institution_en><team_members_id>19202</team_members_id><team_members_names><![CDATA[ Doktorand: Ivana Tomljanović ]]></team_members_names><keywords_hr><![CDATA[regeneracija sisavaca, Monodelphis domestica, oposum, embrionalni razvoj, središnji živčani sustav, leđna moždina, rast aksona, proteomika]]></keywords_hr><keywords_en><![CDATA[mammalian regeneration, Monodelphis domestica, opossum, embryonal development, central nervous system, spinal cord, axonal growth, proteomics]]></keywords_en><summary_hr><![CDATA[Jedan od glavnih izazova suvremene biologije je nemogućnost odraslog središnjeg živčanog sustava (SŽS) sisavaca da se regenerira i oporavi nakon ozljede. Za razliku od odraslih sisavaca, niži kralježnjaci, kao što su ribe i vodozemci, te viši kralježnjaci tijekom embrionalnog razvoja mogu obnoviti znatan dio svog SŽS. Vrlo je nejasno kako se i zašto regenerativni potencijal gubi tijekom evolucije i razvoja i zašto je vrlo ograničen u odraslih sisavaca. Povoljan model za istraživanje i otkrivanje osnove ovog gubitka je mladi oposum (Monodelphis domestica). Oposumi su tobolčari koji se rađaju vrlo nezreli i imaju jedinstvenu mogućnost uspješne regeneracije leđne moždine nakon ozljede u prva dva tjedna svog života, te stoga pružaju izuzetnu priliku za istraživanje neuronalne regeneracije. U svojim sam prethodnim istraživanima identificirala gene čiji se izražaj razlikuje u tkivu leđne moždine oposuma koji imaju ili nemaju sposobnost regeneracije. U ovom istraživanju želimo nadograditi prijašnji pristup analizom proteoma tkiva leđne moždine oposuma različite dobi, kako bi se otkrile molekule povezane s regenerativnim rastom aksona i proliferacijom matičnih stanica. Inhibicijom aktivnosti odabranih molekula ispitat će se njihova funkcionalna uloga u regeneraciji živčanog tkiva, koristeći in vitro preparate intaktne leđne moždine i napredno mikroskopiranje. Paralelno, pripremiti ćemo i analizirati primarne stanične kulture iz tkiva leđne moždine oposuma različite dobi, kako bi testirali odabrane molekule, s težištem na onima koje kontroliraju aktivnost matičnih stanica vezanu za regeneraciju. Ovo originalno interdisciplinarno temeljno istraživanje koristi jedinstveni životinjski model i ujedinjuje napredne tehnike biotehnologije te molekularne i stanične neurobiologije. Rezultati ovog projekta mogli bi dati značajan doprinos razumijevanju regeneracije živčanog tkiva sisavaca, ali i pružiti osnovu za buduće nove terapijske postupke vezane za neurodegenerativne poremećaje.]]></summary_hr><summary_en><![CDATA[One of the major challenges of modern biology concerns the inability of the adult mammalian central nervous system (CNS) to regenerate and repair itself after injury. Unlike the situation in adult mammals, lower vertebrates, such as fish and amphibians, and embryonal higher vertebrates can regenerate significant portions of their CNS. It is poorly understood why this potential is lost with evolution and development, and becomes very limited in adult mammals. An advantageous model to understand the basis of this loss is the neonatal opossum (Monodelphis domestica). Opossums are marsupials born immature, with the unique ability to successfully regenerate spinal cord after injury postnatally: this property, therefore, offers an exceptional tool to study neuro-regeneration. In my previous studies I have identified the genes differentially expressed in the regenerating and non-regenerating opossum spinal tissue. In the present application we wish to upgrade approach and to analyze the proteoms of the spinal tissue of the opossums at different ages, looking for molecules associated with regenerative axon growth and stem cell proliferation. The activity of candidate molecules will be inhibited to investigate their functional role in neuronal regeneration using the in vitro intact spinal cord preparation and advanced imaging. In parallel, we will prepare and analyze opossum primary spinal cell cultures made from the animals of different age, to test candidate proteins, with focus on those involved in stem/progenitor cell activity related to regeneration. This original interdisciplinary basic research project, unique in the choice of the animal model to be used, combines advanced techniques of biotechnology and molecular and cellular neurobiology. The results of the project would make substantial contribution to our understanding of neuronal regeneration in mammals, and also provide candidate targets for future novel therapeutic interventions for neurodegenerative disorders.]]></summary_en></project><project>
<id>7290</id><title_hr><![CDATA[Sustav vjetar-sunce za optimiziranu proizvodnju električne energije u rezidencijalnim objektima]]></title_hr><title_en><![CDATA[]]></title_en><user_id>11280</user_id><user_firstLast_name>Mateo Bašić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-01</proposal_call><code>DOK-2018-01-9865</code><acronim><![CDATA[WINDSOR]]></acronim><duration>17.10.2018 - 01.01.2023</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Elektrotehnika, </scie_field_hr><scie_field_en>Electrical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Splitu, Fakultet elektrotehnike, strojarstva i brodogradnje]]></institution_hr><institution_en><![CDATA[University of Split, Faculty of Electrical Engineering, Mechanical Engineering and Naval Architecture]]></institution_en><team_members_id>25306</team_members_id><team_members_names><![CDATA[ Doktorand: Matija Bubalo ]]></team_members_names><keywords_hr><![CDATA[Proizvodnja električne energije, Samouzbudni asinkroni generator, Fotonaponski sustav, Modeliranje, Umjetna inteligencija, Optimizacija]]></keywords_hr><keywords_en><![CDATA[Electric power generation, Self-excited induction generator, Photovoltaic system, Modelling, Artificial Intelligence, Optimization]]></keywords_en><summary_hr><![CDATA[Važna motivacija za izradu predloženog projekta je potreba gradskih područja za zelenom i povoljnom energijom. U okviru ovog istraživačkog projekta razvit će se sustav za optimiziranu proizvodnju električne energije koji kao izvore električne energije sadrži vjetroagregat sa samouzbudnim asinkronim generatorom (SEIG od engl. Self-Excited Induction Generator), fotonaponski sustav i baterije. Predloženi sustav će se istraživati u otočnom režimu rada kao i s priključkom na električnu mrežu.Specifični ciljevi projekta su sljedeći: (i) Razvoj naprednog modela SEIG-a i pripadajućeg sustava vektorske regulacije s vjetroturbinom i trofaznim PWM-upravljanim ispravljačem, koji će uključivati: optimizaciju korisnosti vjetroagregata primjenom neizrazite logike; detekciju brzine vrtnje SEIG-a bez upotrebe mjernog člana; regulaciju napona SEIG-a primjenom naprednog regulatora temeljenog na teoriji algebre granica i genetičkim algoritmima te optimizaciju PWM modulacije ispravljača. (ii) Razvoj izmjenjivača kvazi Z-tipa čiji ulaz čini istosmjerna sabirnica na koju su priključeni PWM-upravljani ispravljač, fotonaponski sustav i baterije, a izlaz se koristi za napajanje trofaznih izmjeničnih trošila ili za priključak na električnu mrežu. Za potrebe sinkronizacije ovog izmjenjivača s električnom mrežom razvit će se novi sustav fazno zatvorene petlje temeljen na teoriji algebre granica i genetičkim algoritmima.(iii) Razvoj simulacijskog modela fotonaponskog sustava koji će uključivati utjecaj osunčanosti fotonaponske ćelije na njenu temperaturu, kapacitet diode fotonaponske ćelije te korekciju uobičajenog izraza za struju zasićenja diode. Za potrebe optimizacije korisnosti fotonaponskog sustava razvit će se algoritam za praćenje točke maksimalne snage, spregnut s regulacijom ulaznog napona izmjenjivača kvazi Z-tipa.Planirano istraživanje će se provesti u suradnji sa znanstvenicima iz Instituta informatičke tehnologije u Hanoju i Fakulteta elektronike u Thai Nguyenu. ]]></summary_hr><summary_en><![CDATA[An important motivation for the proposed project is the need of urban areas for green and affordable energy.Under this research project, a wind-solar system for optimized electric generation will be developed, containing a wind energy conversion system (WECS) with a self-excited induction generator (SEIG), a photovoltaic (PV) system, and batteries as sources of electric power. The proposed system will be investigated in island mode and in grid-connected mode.The specific objectives of the project are as follows:(i) Development of an advanced SEIG model and a corresponding vector control system with a wind turbine and a three-phase PWM-controlled rectifier, which will include the following features: fuzzy-logic-based optimization of the WECS’s efficiency; sensorless detection of the SEIG’s speed; control of the SEIG’s voltage by means of an advanced controller based on the hedge algebra theory and genetic algorithms, and optimization of the rectifier PWM control.(ii) Development of a quasi-Z-source inverter (qZSI) whose input is connected to a DC bus to which the PWM-controlled rectifier, the PV system, and the batteries are also connected, whereas the output of the qZSI is used for supplying three-phase AC loads or for connection to the electric grid. For the purpose of synchronization of the qZSI with the electric grid, a new phase-locked loop will be developed based on the hedge algebra theory and genetic algorithms.(iii) Development of a simulation model of the PV system including the impact of the PV cell irradiance on its temperature, the capacitance of the PV cell diode, and correction of the common term for the diode saturation current. A maximum-power-point-tracking algorithm, coupled with the control of the qZSI’s input voltage, will be developed for optimization of the PV system’s efficiency.The planned research will be carried in collaboration with researchers from the Institute of Information Technology, Hanoi, and Faculty of Electronics, Thai Nguyen.]]></summary_en></project><project>
<id>7292</id><title_hr><![CDATA[Rogozničko morsko jezero kao model odziva ekosustava na promjene u okolišu]]></title_hr><title_en><![CDATA[MARine lake (Rogoznica) as a model for EcoSystem functioning in a changing environment]]></title_en><user_id>287</user_id><user_firstLast_name>Irena  Ciglenečki-Jušić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2018-01</proposal_call><code>IP-2018-01-1717</code><acronim><![CDATA[MARRES]]></acronim><duration>22.10.2018 - 21.10.2022</duration><status>Završio</status><financ_value>134.806,56 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Interdisciplinarne prirodne znanosti, Matematika, Fizika, Kemija, Biologija, </scie_field_hr><scie_field_en>Interdisciplinary natural sciences, Mathematics, Physics, Chemistry, Biology, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>454, 3702, 1020, 3035, 290, 19245, 19525, 2977, 278, 17873, 1155, 19321, 4486, 23749, 25748, 856281, </team_members_id><team_members_names><![CDATA[Palma  Orlović-Leko, Tatjana Bakran-Petricioli, Mathieu Dutour Sikirić, Katja Magdić Košiček, Marija Marguš, Željko Grahek, Ivana  Tucaković, Iris Dupčić Radić, Milan Čanković, Ana  Cvitešić Kušan, Jelena Dautović, Ivana Coha, Donat Petricioli, Kristijan Vidovic, Sarah Mateša, Niki Simonović, ]]></team_members_names><keywords_hr><![CDATA[Rogozničko jezero,  specijacija i dinamika S spojeva,biogeokemijski procesi, unos iz atmosfere,  radionuklidi ]]></keywords_hr><keywords_en><![CDATA[Rogoznica lake, S speciation and dynamics, biogeochemical processes, atmospheric input, radionuclides]]></keywords_en><summary_hr><![CDATA[MARRES, nastavak SPHERE projekta, ima za cilj koristiti jedinstveni okoliš Rogozničkog jezera kao primjer  ugroženog morskog sustava koji odražava sve hidrografske i atmosferske uvjete Jadranskog mora. U okviru MARRES-a  Rogozničko jezero biti će model za praćenje i karakterizaciju biogeokemijskih procesa kruženja sumpora i ugljika na različitim redoks granicama faza, odnosno pri različitim okolišnim uvjetima. Znanstvenu misiju MARRES će postići suvremenim laboratorijskim tehnikama i radom na terenu, objedinjenim u jedinstveno biogeokemijsko istraživanje. Važan dio projekta biti će usmjeren na transport i izmjenu između atmosfere, vodenog stupca i sedimenta jezera, mjerenjem unosa sumpornih spojeva, organske tvari, radionuklida, nutrijenata i tragova metala mokrim taloženjem iz kiše. Ovisno o specifičnim fizičko-kemijskim uvjetima  pratiti će se i diskutirati ekologija mikroorganizama, fito- i zoo-planktona, te bentosa. Analiza i rasprava novih i dugoročnih podataka ekološkog  statusa jezera, osnovni je preduvjet za razvoj biogeokemijskog modela. Osim Rogozničkog jezera, drugi sustav za praćenje promjena u okolišu povezanih s eutrofikacijom, biti će sjeverni Jadran kao primjer poluzatvorenog, plitkog i potencijalno eutrofnog morskog bazena s povremenim pojavama pridnene anoksije. Istraživanja MARRESa planirana su na vremenskoj skali  od 4 godine, a dobiveni rezultati će značajno pridonijeti općem znanju o stanju i odgovorima istraživanih ekosustava na promjene fizikalnih, kemijskih i bioloških uvjeta uslijed prirodnih i antropogenih, odnosno globalnih promjena u okolišu. Gore navedeni istraživački ciljevi, posebice oni vezani za mobilizaciju ljudskih, tehničkih i infrastrukturnih kapaciteta IRB-a, kao i uključenih partnerskih institucija, usko su usklađeni sa strateškim prioritetima i promicanjem hrvatske znanosti, znanja i iskustva na svjetskom znanstvenom tržištu.]]></summary_hr><summary_en><![CDATA[MARRES, the continuation of the SPHERE project, aims to put in focus Rogoznica lake as an unique example of the threatened marine ecosystems, which feels hydrographic and atmospheric conditions of the Adriatic Sea. Rogoznica lake will be a model for monitoring and characterization of biogeochemical processes related to sulfur and carbon cycling at different redox boundaries under different environmental conditions. The project will achieve scientific mission by state-of-the art laboratory studies and field monitoring integrated in an unique biogeochemical research. Discussion and synthesis of new and long term data of the Lake’s ecological status is fundamental for development of biogeochemical model. An important part of the project will be focused on the exchange and transport between atmosphere, water column and sediment by measuring the atmospheric input (wet deposition) of sulfur compounds (organic and inorganic), organic carbon, radionuclides (Be-7, Pb-210), nutrients and trace metals. Additionally, the ecology of the microorganisms, phyto-  and zoo-plankton, bentos will be correlated with specific lake water physico-chemical conditions. The northern Adriatic as a semi closed, shallow and potentially eutrophic marine basin with occasional appearance of bottom anoxia will be used as another system for tracking environmental changes related to eutrophication. The MARRES is planned for the period of 4 years, and its result will contribute substantially to the improvement of the knowledge on the studied ecosystems responses to likely changes of physical, chemical and biological conditions affected by natural and anthropogenic i.e. global environmental change. Research objectives listed above, especially those related to mobilization of human, technical, and infrastructural capacities of the RBI and involved partner Institutions  are closely in line with strategic priorities and promotion of Croatian science, knowledge and experience on the world science market.]]></summary_en></project><project>
<id>7294</id><title_hr><![CDATA[Vitalitet obične bukve (Fagus sylvatica L.) u izmijenjenim klimatskim uvjetima]]></title_hr><title_en><![CDATA[Vitality of common beech (Fagus sylvatica L.) in changing climate conditions]]></title_en><user_id>848</user_id><user_firstLast_name>Nenad Potočić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2018-01</proposal_call><code>IP-2018-01-5222</code><acronim><![CDATA[VitaClim]]></acronim><duration>01.11.2018 - 31.10.2022</duration><status>Završio</status><financ_value>131.881,72 eur</financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Šumarstvo, Interdisciplinarne biotehničke znanosti, </scie_field_hr><scie_field_en>Forestry, Interdisciplinary biotechnical sciences, </scie_field_en><institution_hr><![CDATA[Hrvatski šumarski institut]]></institution_hr><institution_en><![CDATA[Croatian Forest Research Institute]]></institution_en><team_members_id>849, 23575, 13518, 19450, 19502, 19459, 19870, 19035, 23784, 1121, 861738, </team_members_id><team_members_names><![CDATA[Ivan Seletković, Mladen Ognjenović, Tomislav Levanič, Jonard Mathieu, Pasi Rautio, Volkmar Timmermann, Nicole Wellbrock, Miran Lanšćak, Karin Rebel, Renata Sokol Jurković, Mia Marušić, ]]></team_members_names><keywords_hr><![CDATA[defolijacija, prirast, ishrana bilja, fotosinteza, modeliranje, rasadnički pokus]]></keywords_hr><keywords_en><![CDATA[defoliation, increment, foliar nutrition, photosynthesis, modelling, nursery trial]]></keywords_en><summary_hr><![CDATA[Vitalitet ili stanje stabla možemo definirati kao sposobnost stabla da asimilira, preživi stres i reagira na promjenu okolišnih uvjeta. Promijenjeni klimatski uvjeti smatraju se kritičnim za stanje stabala, jer određuju dostupnost vode u smislu njezine apsorpcije i transporta u drveću, a nedostatak vode uzrokuje nedostatnu ishranu biljaka i posljedični gubitak vitaliteta. Osnovni cilj ovog projekta je istražiti utjecaj promijenjenih klimatskih uvjeta na različite indikatore vitaliteta drveća, kao i njihove moguće međuovisnosti.Koristit ćemo nacionalne i europske podatke o osutosti obične bukve iz baze podataka ICP Forests programa i upotpuniti ih uzorkovanjem lišća, tla i izvrtaka stabala bukve na ICP Forests plohama razine I u Hrvatskoj. Povijesni klimatski podaci i projekcije klime biti će korišteni za daljnje analize. Modelirati ćemo promjene osutosti kroz vrijeme i prostor i odrediti utjecaj klimatskih uvjeta na osutost bukve ujedno ispitujući prikladnost pojedinih statističkih metoda. Istražit ćemo utjecaj klimatskih uvjeta na ishranu bukve biogenim makroelementima i odrediti da li se njihove koncentracije razlikuju u odnosu na osutost stabala. Naš je cilj također utvrditi postoje li povezanosti osutosti i debljinskog prirasta, uključujući mogući efekt kašnjenja. Konačno, fiziologija stresa obične bukve biti će istražena u kontroliranim uvjetima analizirajući fotosintezu, rast i ishranu sadnica u uvjetima sušnog stresa i za vrijeme oporavka od suše, upotpunjujući naša planirana istraživanja u bukovim sastojinama.Rezultati ovog projekta osigurati će podlogu za različite procese odlučivanja vezane uz gospodarenje šumama, usluge šumskih ekosustava, izvješćivanje o stanju šuma kao i planiranje u svrhu smanjenja posljedica klimatskih promjena. ]]></summary_hr><summary_en><![CDATA[Tree vitality or condition can be defined as the ability of a tree to assimilate, to survive stress and to react to changing conditions. Changing climate properties can be critical for the condition of trees, as they can bring about the disturbed water absorption and transport, and water deficits may cause inadequate nutrition of trees with a subsequent loss of tree vitality. The main goal of this project is to explore the impact of changing climate conditions on various indicators of tree vitality, as well as their possible interrelations.We will use national and Europe-wide data of common beech defoliation from ICP Forests program and complete this data by sampling foliage, soil and increment cores of common beech trees on Croatian ICP Forests Level I plots. Past climate data and climate projections will be used in the subsequent analysis.We aim to model temporal and spatial change of defoliation and determine the influence of climate conditions on common beech defoliation, thereby also testing the suitability of various statistical methods. Furthermore, our objectives are to investigate the influence of climate conditions on foliar mineral nutrition of common beech and determine whether foliar element concentrations differ according to defoliation. We will also establish the relationships between defoliation and radial growth as well as investigate whether defoliation has a lagged effect on radial growth. Finally, the stress physiology of beech will be investigated in a controlled environment by analyzing photosynthesis, growth and nutrition of potted plants under drought stress and during post-drought recovery, complementing the results of the mentioned exploratory research.We expect the results of this project to provide basis for various decision-making processes related to forest management, forest ecosystem services, forest status reporting and climate mitigation planning. ]]></summary_en></project><project>
<id>7295</id><title_hr><![CDATA[Koncept nepomičnog pola u numeričkom modeliranju Cosseratovog kontinuuma]]></title_hr><title_en><![CDATA[Fixed-pole concept in numerical modelling of Cosserats’ continuum]]></title_en><user_id>527</user_id><user_firstLast_name>Gordan Jelenić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2018-01</proposal_call><code>IP-2018-01-1732</code><acronim><![CDATA[FIMCOS]]></acronim><duration>01.01.2019 - 30.06.2023</duration><status>Završio</status><financ_value>131.395,58 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Temeljne tehničke znanosti, Brodogradnja, Građevinarstvo, Metalurgija, Strojarstvo, Zrakoplovstvo, raketna i svemirska tehnika, </scie_field_hr><scie_field_en>Basic engineering sciences, Naval architecture, Civil engineering, Metallurgy, Mechnical engineering, Aerospace, missile and space engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Građevinski fakultet u Rijeci]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Civil Engineering]]></institution_en><team_members_id>1014, 3167, 27510, 17756, 28914, 864842, 866591, 25238, </team_members_id><team_members_names><![CDATA[Dragan Ribarić, Edita Papa Dukić, Laura Žiković, Sara Grbčić Erdelj, Maedeh Ranjbar Zefreh, Magdy Ismail, Damjan Jurković, Marin Grbac, ]]></team_members_names><keywords_hr><![CDATA[Cosseratov kontinuum, opis metodom nepomičnoga pola, metoda konačnih elemenata, objektivnost, konzervativna integracija, identifikacija parametara]]></keywords_hr><keywords_en><![CDATA[Cosserats&#39; continuum, fixed-pole description, finite-element method, objectivity, conservative integration, parameter identification]]></keywords_en><summary_hr><![CDATA[U ovome projektnom prijedlogu razmatra se alternativna teorija kontinuuma poznata pod nazivom Cosseratova ili mikropolarna teorija. Predlaže se provedba detaljnije analize u okviru  takozvane metode nepomičnog pola s ciljem razvoja točnih i djelotvornih konačnih elemenata za linearnu i nelinearnu statičku i dinamičku analizu.Elementi će biti razvijeni slijedom niza istraživačkih ciljeva koji se sastoje od (O1) linearne statičke analize, (O2) nelinearne statičke analize, (O3) dinamičke analize i (O4) identifikacije parametara. Na taj način, putem ciljeva O1-O3 razvijeni elementi će tvoriti simulacijski alat sami za sebe, dok će putem cilja O4 stvoriti neophodni preduvjet za robusnu i pouzdanu proceduru potrebnu za identifikaciju materijalnih parametara iz eksperimentalnih mjerenja. Konačni elementi će biti provjereni putem niza standardnih testnih primjera, a par eksperimentalnih postava bit će projektiran da zaključi cilj O4. Ciljevi će biti dosegnuti kroz niz istraživačkih, edukacijskih i upravljačkih aktivnosti koje će voditi članovi projektne grupe i koji će se bazirati na ranijim dostignućima grupe u razvoju konačnih elemenata uključujući vezanu interpolaciju, objektivnu interpolaciju ovisnu o konfiguraciji, algoritme za vremensku integraciju, Cosseratovu elastičnost, metodu nepomičnog pola u nelinearnim gredama i iskustvo u provedbi beskontanog mjerenja. Konačni elementi će biti razvijeni unutar programa za analizu metodom konačnih elemenata FEAP.S projektnim rezultatima upoznat ćemo eksperte i širu javnost putem raznih diseminacijskih kanala, uključujući objave u znanstvenim časopisima najviše kategorije u području računske mehanike, predstavljanja na uglednim specijaliziranim konferencijama, kao i predavanja s ciljem populariziranja projektnoga istraživanja i znanosti općenito.]]></summary_hr><summary_en><![CDATA[An alternative continuum theory called Cosserats’ or micropolar theory is considered within this proposal and a case is made for its more thorough analysis within the framework of the so-called fixed-pole description with the aim of providing accurate and efficient finite elements for linear and non-linear static and dynamic analysis. The elements will be developed by pursuing a set of research objectives consisting of (O1) linear static analysis, (O2) non-linear static analysis, (O3) dynamic analysis and (O4) parameter identification. In this way, through objectives O1-O3 the elements developed will be usable as a simulation tool in their own right while in O4 they will make a vital pre-requisite for a robust and reliable procedure needed for identification of material parameters from experimental measurements. The finite elements will be tested against a number of bench-mark problems, while a couple of experimental setups will be designed to complete O4.The objectives will be reached through a series of research, training and management activities led by the members of the project team and built on previous achievements of the team in finite-element design involving linked interpolation, objective configuration-dependent interpolation, time-stepping algorithms, conventional Cosserats&#39; elasticity, fixed-pole approach in geometrically exact beams as well as experience in performing contactless measurements. The finite elements will be developed within the finite-element-analysis programme FEAP.The project results will be communicated to the professionals and general public through a variety of dissemination channels involving publications in the scientific journals of the highest rank within the area of computational mechanics, presentations at highly reputable thematic conferences, and lectures aimed at popularising the project research and science in general.]]></summary_en></project><project>
<id>7304</id><title_hr><![CDATA[Preuređivanje memorije: Manipuliranje T-staničnom memorijom u svrhu unapređenja učinkovitosti cjepiva]]></title_hr><title_en><![CDATA[]]></title_en><user_id>19051</user_id><user_firstLast_name>Felix Wensveen</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-01</proposal_call><code>DOK-2018-01-2835</code><acronim><![CDATA[T-MEMORY]]></acronim><duration>02.07.2018 - 01.07.2020</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Medicine]]></institution_en><team_members_id>19748</team_members_id><team_members_names><![CDATA[ Doktorand: Inga Kavazović ]]></team_members_names><keywords_hr><![CDATA[T Stanična memorija, infekcija, rak, Eomes, T stanični receptor]]></keywords_hr><keywords_en><![CDATA[T cell memory, infection, cancer, Eomes, T cell receptor]]></keywords_en><summary_hr><![CDATA[Imunost posredovana CD8 T-limfocitima pruža nam zaštitu od brojnih patogena i tumora. Naivni repertoar limfocita T se sastoji od milijuna različitih klonova koji se međusobno razlikuju po specifičnosti svojih T-staničnih receptora. Prilikom infekcije, samo neki od klonova postaju dugovjeke memorijske stanice. Selekcijski proces odabira memorijskih klonova reguliran je ravnotežom između specifičnosti i raznolikosti kako bi se osigurao učinkovit sekundarni odgovor te mogućnost prepoznavanja istih, mutiranih antigena. Mehanizmi koji kontroliraju raznolikost memorije još uvijek nisu razjašnjeni. Naša grupa je prepoznala Eomes kao ključni transkripcijski čimbenik za formiranje memorije, no kako pojačana ekspresija Eomesa rezultira stvaranjem imunološke memorije je idalje nepoznato.	U ovom projektu, istražit ćemo utjecaj intenziteta signala i aktivacije T-staničnog receptora na formiranje memorije putem Eomes-a. Prvo ćemo ispitati kako razlike u jačini stimulacije utječu na kvantitativnu i kvalitativnu aktivaciju glavnih nizvodnih komponenti te način na koji se taj signal prevodi u određenu razinu ekspresije Eomes-a. Paralelno, proučavat ćemo i način na koji Eomes pretvara taj aktivirajući signal određene jačine u molekularni proces koji rezultira stvaranjem imunološke memorije. U trećoj fazi projekta utvrditi ćemo ključne čimbenike koji posreduju tim procesima. Još bitnije, usredotočit ćemo se na čimbenike koji mogu imati terapeutsku primjenu kako bi testirali učinkovitost specifičnog ciljanja tih molekula na unaprjeđenje antitumorskih i antivirusnih cjepiva.	Ovdje predstavljeni projektni prijedlog, osim iznimne inovativnosti, ima velike izglede za uspjeh budući da se temelji na velikoj količini preliminarnih rezultata. Uz to, jedna od ključnih prednosti je i naše dugogodišnje iskustvo i rad u području imunologije i istraživanja na životinjama. Stoga držimo da je ovaj projekt izvrsna investicija u hrvatsku akademsku zajednicu koja pomaže razvoju nove istraživačke grupe.]]></summary_hr><summary_en><![CDATA[CD8 T cell mediated immunity protects us against pathogens and cancer. The naive T cell pool consists of millions of clones, each one unique based on its T cell receptor (TCR). Upon infection, only a few of these clones are recruited to generate antigen-specific memory. Selection of memory clones is a trade-off between specificity and diversity to ensure both an efficient recall response and recognition of a sufficient number of targets. Mechanisms controlling memory diversity are largely unclear. Recently, we have identified the transcription factor Eomes as a key mediator of memory formation. How Eomes induction results in shaping of the memory cell pool is currently unknown.  	In this project, we will study the impact of activating T cell receptor signal intensity on memory formation via the transcription factor Eomes. First, we will investigate how TCR signal strength impacts the quality and quantity of activation of its main downstream components and how this translates into the activation of Eomes. In parallel, we will investigate how Eomes translates TCR-activating stimuli of a given strength in a molecular process that promotes memory formation. Using the combined information of these two lines of inquiry, we will identify and validate key factors that mediate these processes in the third phase of the project. Importantly, we will select for molecules that can be targeted by pharmacological means. Finally, we will test the potency of therapeutic intervention for the improvement of antiviral and anti-cancer vaccines. 	The proposal described here is both innovative, and has a high chance of success, since it is based on a large amount of preliminary data. This project builds on the strengths that our department has developed in the fields of immunology and animal research, while adding a fresh impulse of innovation. We therefore believe that this project is a solid investment in Croatian academia and aids in the development of a strong new research group. ]]></summary_en></project><project>
<id>7309</id><title_hr><![CDATA[Izračun antropometrijskih mjera pametnim telefonom i tabletom]]></title_hr><title_en><![CDATA[Smartphone and Tablet Extraction of Anthropometric Measurements]]></title_en><user_id>6456</user_id><user_firstLast_name>Tomislav Pribanić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2018-01</proposal_call><code>IP-2018-01-8118</code><acronim><![CDATA[STEAM]]></acronim><duration>01.02.2019 - 31.01.2023</duration><status>Završio</status><financ_value>127.281,17 eur</financ_value><scie_area_hr>Tehničke znanosti, Biomedicina i zdravstvo, Društvene znanosti, </scie_area_hr><scie_area_en>Technological sciences, Biomedicine and health sciences, Social sciences, </scie_area_en><scie_field_hr>Računarstvo, Elektrotehnika, Tekstilna tehnologija, Kliničke medicinske znanosti, Kineziologija, </scie_field_hr><scie_field_en>Computer sciences, Electrical engineering, Textile technology, Clinical sciences, Kinesiology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id>4325, 6749, 23587, 23795, 23675, 23773, 23805, 6641, 23726, 7674, 7677, 27996, 861754, </team_members_id><team_members_names><![CDATA[Slavenka Petrak, Stanislav Peharec, Simone Gasparini, Stefan Gumhold, Anita Busic, Yago Diez Donoso, Zhan Song, Tomislav Petković, Davor Šentija, Nicola D&amp;#39;Apuzzo, Joaquim Salvi, Kristijan Bartol, David Bojanić, ]]></team_members_names><keywords_hr><![CDATA[3D skeniranja tijela, antropometrija, 3D antropometrijski podaci, ljudska postura, karakteristične točke tijela, tablet,pametni telefon, računalni vid]]></keywords_hr><keywords_en><![CDATA[3D body scan measurement, anthropometry, 3D anthropometric data, human posture, body landmark detection, tablet, smartphone, computer vision]]></keywords_en><summary_hr><![CDATA[Izrada 3D modela iz fotografija je jedna od glavnih zadaća računalnog vida, grane umjetne inteligencije u području računalne znanosti koja istražuje metodologiju izdvajanja informacija iz digitalnih slika. Dobivanje kvalitetnih 3D modela više nije ograničeno na obradu i istraživanje korištenjem stolnih računala i/ili prijenosnih računala visokih performansi. Moderni i moćni pametni telefoni te tableti (mobilne platforme) također otvaraju mogućnosti definiranja novih metoda za 3D rekonstrukciju. Dotično istraživanje ima dva glavna dijela. Prvi dio odnosi se na razvoj i implementaciju učinkovitih 3D algoritama rekonstrukcije optimiranih za posebnosti mobilnih platformi. Proširivanje funkcionalnosti pametnog telefona ili tableta prema 3D uređaju za skeniranje je značajno ne samo s gledišta znanstvenog istraživanja već i za potencijalnu industrijsku primjenu (ekonomsko iskorištavanje). Stoga je drugi dio ovog rada usmjeren na procjenu antropometrijskih veličina uporabom 2D i 3D podataka s mobilnih platformi. Antropometrijska mjerenja su od velikog značaja širokoj skupini korisnika jer antropometrija danas igra važnu ulogu u industrijskom dizajnu, dizajnu odjeće, ergonomiji, medicini i arhitekturi gdje se statistički podaci o raspodjeli dimenzija tijela u populaciji koriste za optimizaciju različitih proizvoda i usluga.]]></summary_hr><summary_en><![CDATA[The generation of 3D models from still images has been a long term goal in computer vision, a branch of artificial intelligence in the field of computer science which explores the state machines and models for extracting information from the digital images. Acquiring high quality 3D models is no longer restricted to processing on desktop computers and high end laptops. Modern and powerful smartphones and tablets (mobile platforms) open up the possibilities designing new methods for 3D reconstruction. The scope of this work is twofold. First part concerns the development and implementation of the efficient 3D reconstruction algorithms optimized for the mobile platforms features. Extending smartphone or tablet functionality towards 3D scanning device is interesting both for the scientific research and for the industrial (economic) exploitation as well. Therefore, the second part of this work is aimed at estimation of anthropometric measurements combining 2D and 3D data from mobile platforms. Anthropometric measurements are of particular interest to a large group of beneficiaries since nowadays anthropometry plays an important role in industrial design, clothing design, ergonomics, medicine and architecture where statistical data about the distribution of body dimensions in the population are used to optimize various products and services.]]></summary_en></project><project>
<id>7310</id><title_hr><![CDATA[Pojavnost, patogenetska obilježja i klinički značaj donor-specifičnih HLA i ne-HLA protutijela u bolesnika s presađenim bubregom]]></title_hr><title_en><![CDATA[Frequency, pathogenic characteristics and clinical significance of donor-specific HLA and non-HLA antibodies in kidney transplant recipients]]></title_en><user_id>3838</user_id><user_firstLast_name>Mladen Knotek</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2018-01</proposal_call><code>IP-2018-01-4737</code><acronim><![CDATA[PoPAtPB]]></acronim><duration>02.11.2018 - 01.11.2022</duration><status>Prekinut</status><financ_value>132.722,81 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Kliničke medicinske znanosti, Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Clinical sciences, Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb School of Medicine]]></institution_en><team_members_id>3058, 24127, 24145, 24143, 24140, 24152, 5638, 4404, 13626, 4204, 4175, 3902, 23494, 24158, 5934, 4118, 24147, 24154, 5341, 6247, 24228, </team_members_id><team_members_names><![CDATA[Renata Žunec, Bojana Šimunov, Snježana Šulc, Ivan Margeta, Branislav Čingel, NATALIJA MARTINEZ, Zorana Grubić, Bojana Maksimović, Željka Jureković, Lada Zibar, Ivan Neretljak, Danica Galešić Ljubanović, Ksenija Vučur, Mario Sučić, Dinko Škegro, Mihaela Gunjača, Marija Maskalan, Biserka Palfi, Katarina Štingl Janković, MARIJA BUREK KAMENARIĆ, Goran Radulović, ]]></team_members_names><keywords_hr><![CDATA[transplantacija bubrega, HLA sustav, ne-HLA protutijela, HLA protutijela, odbacivanje, imunosupresija]]></keywords_hr><keywords_en><![CDATA[kidney transplantation, HLA system, non-HLA antibodies, HLA antibodies, rejection, immunosuppression]]></keywords_en><summary_hr><![CDATA[Humoralna aloimunost je glavni patogeni imunološki mehanizam u transplantaciji bubrega. Anti-HLA i ne-HLA protutijela posreduju odbacivanje bubrega protutijelima. Zasebni doprinos pojedine od tih kategorija protutijela, kao i njihov mogući sinergističkin učinak nisu dovoljno istraženi. Također, novi pristupi tipizaciji tkiva, odn. tkivnoj nepodudarnosti temeljeni na analizi epleta trebao bi doprinijeti smanjenju učestalosti odbacivanja posredovanog protutijelima. Ovaj projekt bi trebao istražiti ishod transplantacije u ovisnosti o odbacivanju posredovanom protutijelima i ulozi HLA i ne-HLA protutijela. Trebao bi istražiti i povezanost nepodudarnosti u epletima s ishodom transplantacije. Projekt će rezultirati novim spoznajama o patogenezi odbacivanja, i informirat će stručnu zajednicu za buduće donošenje hrvatskih smjernica o HLA tipizaciji i imunološkom nadzoru prije i nakon transplantacije bubrega.]]></summary_hr><summary_en><![CDATA[Humoral alloimmunity is the major pathogenic mechanism in kidney transplantation. Anti-HLA antibodies, as well as non-HLA antibodies participate in kidney graft rejection and loss. However, contribution of a particular type of antibodies in graft rejection and their possible synergistic effect has not been suficiently expolred. Better HLA matching should decrease rate of antibody-mediated rejection. In this project we plan to explore eplet-based HLA matching and the role of complement-binding HLA and non-HLA antibodies in kidney graft outcome. This project will result in more knowledge on pathogenesis of antibody-mediated rejection and its role on long-term graft outcomes. It will also form basis for Croatian guidelines on HLA typing and immune pre- and post-transplant surveillance in kidney transplantation]]></summary_en></project><project>
<id>7312</id><title_hr><![CDATA[Molekularno prepoznavanje DNA:RNA hibridnih i višelančanih struktura u bioanalitičkim i in vitro sustavima]]></title_hr><title_en><![CDATA[Molecular recognition of DNA:RNA hybrid and multistranded structures in bioanalytical and in vitro systems]]></title_en><user_id>1214</user_id><user_firstLast_name>Marijana Radić Stojković</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2018-01</proposal_call><code>IP-2018-01-4694</code><acronim><![CDATA[DNARNAHyB-MolBio]]></acronim><duration>01.10.2018 - 30.09.2022</duration><status>Završio</status><financ_value>127.015,73 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Interdisciplinarne prirodne znanosti, Kemija, Biologija, </scie_field_hr><scie_field_en>Interdisciplinary natural sciences, Chemistry, Biology, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>2953, 2522, 23593, 5964, 1232, 23560, 3527, 2974, 3713, 26556, 865135, </team_members_id><team_members_names><![CDATA[Lidija-Marija Tumir, Renata Kobetić, Filip Šupljika, Ljubica Glavaš-Obrovac, Ivo Crnolatac, Corrado Tringali, Ranko Stojković, Sanja Tomić, Anamaria Brozović, Iva Zonjić, SURESH SHANMUGAM, ]]></team_members_names><keywords_hr><![CDATA[DNA:RNA hibridne i višelančane strukture, molekularno prepoznavanje, metode visoke propusnosti, potencijal vezanja, antproliferativna aktivnost]]></keywords_hr><keywords_en><![CDATA[DNA:RNA hybrid and multistranded structures, molecular recognition, high-throughput methods, binding potential, antiproliferative activity]]></keywords_en><summary_hr><![CDATA[DNA:RNA hibridne i višelančane strukture stvaraju se kao prijelazne strukture tijekom mnogih biološki važnih procesa ako što su replikacija DNA, transkripcija, replikacija telomera i virusa HIV. Stoga predstavljaju atraktivne mete za male molekule osobito zato što nema puno literaturnih izvora koji navode ligande sa selektivnim vezanjem na te mete. Za ispunjavanje glavnog cilja projekta, potraga za novim strukturnim motivima/spojevima sa preferencijalnim vezanjem na DNA:RNA hibridne i višelančane strukture u odnosu na regularne DNA i RNA dvolančane i jednolančane strukture, prvo moraju biti ispunjeni drugi ciljevi: formiranje biblioteke spojeva sa strukturnim motivom potrebnim za prepoznavanje ovih meta, uvođenje i primjena novih DNA i RNA meta (DNA:RNA hibridne i višelančane strukture) i metoda visoke propusnosti  (kompeticijska dijaliza, temperaturno mekšanje smjesa, RNaseH test) u područje istraživanja projektnog tima, koje bi omogućile brzi probir spojeva sa sposobnošću prepoznavanja tih meta. Slijedeći cilj je detaljno istražiti način vezanja izabranih kompleksa ligand-DNA/RNA u bioanalitičkim sustavima (vodene puferirane otopine) pomoću spektroskopskih, kalorimetrijskih i komputacijskih metoda. Istražiti ćemo također moguću korelaciju između visokog veznog potencijala izabranih spojeva i antiproliferativne aktivnosti u kulturi stanica (MTT, protočna citometrija, konfokalna mikroskopija). Očekivani rezultati, ispunjavanje gore navedenih ciljeva, mogu se iskoristiti za: proširivanje osnovnog znanja u ovom području istraživanja, optimizaciju strukture spojeva s ciljem poboljšavanja njihove selektivnosti vezanja prema željenim DNA i RNA metama, moguću medicinsku primjenu, jačanje međuinstitucijske suradnje u Hrvatskoj i razvoj novih znanstvenih ekspertiza što će nama i našim suradnicima omogućiti publiciranje u časopisima visoke kvalitete.]]></summary_hr><summary_en><![CDATA[DNA:RNA hybrid and multistranded structures are formed as intermediate structures during many biologically important processes such as DNA replication, transcription, telomere replication and replication of HIV virus. Therefore, they represent attractive targets for small molecules, especially since the literature citations of the ligands with selective binding to these targets are scarce. To fulfill the main project goal, the search for new structural motives/compounds with preferential binding to DNA:RNA hybrid and multistranded structures vs. regular DNA and RNA duplexes and single-stranded structures, other aims have to be fulfilled first: forming a library of compounds, with structural motif necessary for interaction with these targets, introduction and implementation of new DNA and RNA targets (DNA:RNA hybrid and multistranded structures) and high-throughput methods (competition dialysis, thermal denaturation of mixtures, RNaseH assay) in the research study of our project team, which would enable fast screening of compounds for recognition of these targets. Another aim is to investigate in detail the mode of binding of selected ligand-DNA/RNA complexes in bioanalytical systems (aqueous buffered solutions) by spectroscopic, calorimetric and computational methods. Further, we will investigate the possible correlation between the strong binding potential of selected compounds and their antiproliferative activity in cell culture (MTT, flow cytometry, confocal microscopy).Expected results, fulfillment of the above-mentioned aims can be utilized for: broadening of the basic knowledge in the research area, optimisation of the ligands structure with the goal of improving the binding selectivity to desired DNA and RNA targets, possible medicinal use, strengthening of the inter-organizational collaboration in Croatia and development of novel research expertise that would enable publishing in quality scientific journals.]]></summary_en></project><project>
<id>7315</id><title_hr><![CDATA[Audio tehnologije u sustavima virtualne stvarnosti za primjenu u auralizaciji]]></title_hr><title_en><![CDATA[Audio Technologies in Virtual Reality Systems for Auralization Applications]]></title_en><user_id>3404</user_id><user_firstLast_name>Kristian Jambrošić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2018-01</proposal_call><code>IP-2018-01-6308</code><acronim><![CDATA[AUTAURA]]></acronim><duration>01.01.2019 - 31.03.2023</duration><status>Završio</status><financ_value>132.337,91 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Elektrotehnika, Interdisciplinarne tehničke znanosti, </scie_field_hr><scie_field_en>Electrical engineering, Interdisciplinary technological sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id>19019, 1194, 12899, 962, 3612, 23979, 146, 856245, 21320, </team_members_id><team_members_names><![CDATA[Marko Horvat, Tin Oberman, Miljenko Krhen, Ivan Đurek, Tomislav Jagušt, Monika Rychtarikova, Antonio Petošić, Vedran Planinec, Petar Franček, ]]></team_members_names><keywords_hr><![CDATA[auralizacija, audio, virtualna akustika, virtualna stvarnost, binauralna sinteza, praćenje položaja glave]]></keywords_hr><keywords_en><![CDATA[auralisation, audio, virtual acoustics, virtual reality, binaural synthesis, head tracking]]></keywords_en><summary_hr><![CDATA[Auralizacija pronalazi sve više važnih primjena u svakodnevnom životu razvojem i lakom dostupnošću tehnologija i sustava virtualne stvarnosti. Projekt je fokusiran na istraživanje implementacije auralizacije na različitim sustavima, poglavito korištenjem binauralne tehnologije s dodanim sustavom za praćenje položaja glave. Uz dostupne komercijalne VR sustave, ispitati će se mogućnost uporabe povoljnih inercijskih senzora koji se dodaju jednostavnim ugradbenih sustavima kao alternativna inačica sučelja za auralizaciju radi dodavanja slušnog doživljaja u VR primjenama. Dodatno će se ispitati mogućnost korištenja široko rasprostranjenih pametnih telefona sa svojim već integriranim senzorima pokreta i smjera za potrebe auralizacije koristeći binauralnu tehnologiju. Navedeni sustavi izmjeriti će se i usporediti s obzirom na preciznost, latenciju i stabilnost, a ocijeniti će se i kvaliteta doživljaja prirodnosti virtualnog zvučnog polja na praktičnim primjerima auralizacije u laboratorijskom okruženju i u realnoj situaciji na terenu.]]></summary_hr><summary_en><![CDATA[Auralisation finds more and more important applications in everyday life by the development and broad availability of virtual reality technologies and systems. The project is focused on research of auralisation implementation in different systems, mainly by using binaural technology with an added head tracking system. Beside commercially available VR systems, the possibility of using inexpensive inertial measurement sensors added to simple embedded systems will be investigated as an alternative auralisation system for adding aural experience to VR applications. Additionally, the potential of using widely available smartphones with already integrated movement and direction sensors for auralisation purposes using binaural technology will be examined. The precision, stability and latency of the listed hardware platforms will be measured and compared, and the quality of immersion and naturalness of the virtual sound field in practical auralisation examples will be evaluated, both in laboratory and in-situ conditions.]]></summary_en></project><project>
<id>7318</id><title_hr><![CDATA[Hrvatski mrežni rječnik]]></title_hr><title_en><![CDATA[]]></title_en><user_id>5199</user_id><user_firstLast_name>Lana Hudeček</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-01</proposal_call><code>DOK-2018-01-6111</code><acronim><![CDATA[MREŽNIK]]></acronim><duration>01.09.2018 - 31.08.2021</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Filologija, </scie_field_hr><scie_field_en>Philology, </scie_field_en><institution_hr><![CDATA[Institut za hrvatski jezik]]></institution_hr><institution_en><![CDATA[Institute of Croatian Language]]></institution_en><team_members_id>25202</team_members_id><team_members_names><![CDATA[ Doktorand: Josip Mihaljević ]]></team_members_names><keywords_hr><![CDATA[mrežni rječnik, hrvatski rječnik, jednojezični rječnik,  hipertekstni rječnik, e-leksikografija, e- rječnik, rječnik utemeljen na korpusu]]></keywords_hr><keywords_en><![CDATA[web dictionary, Croatian dictionary, monolingual dictionary,  hipertext dictionary; e-leksicography, e- dictionary, corpus based dictionary]]></keywords_en><summary_hr><![CDATA[U okviru projekta Hrvatski mrežni rječnik (MREŽNIK) izradit će se slobodno dostupan, jednojezični, hipertekstni, jednostavno pretraživ mrežni rječnik hrvatskoga standardnoga jezika od 10 000 natuknica koji će omogućivati interakciju s korisnicima. Natuknice i pojedine riječi i izrazi u rječničkim člancima povezivat će se unakrižno i s natuknicama u bazama podataka koje će nastati u okviru ovoga projekta (baza jezičnih savjeta, baza veznika s opisom vezničkih skupina i njihove modifikacije, baza objašnjenja podrijetla frazema, baza etnika i ktetika). Uz osnovne, rječnik će uključivati i školske definicije (3000) i definicije za strance (1000). Rječnik će biti utemeljen na kopusu (Hrvatska mrežna riznica i Hrvatski mrežni korpus). Uz te će se izvore uzimati u obzir pri uspostavi definicija, donošenju primjera i značenja i svi drugi dostupni tiskani i mrežni izvori. Rječnik će se pisati u programu TLex, prilagođenu za potrebe projekta, a za uvid u korpus upotrijebit će se mrežni alat za pretragu korpusa SketchEngine. Nakon završetka leksikografske obradbe, podatci će biti izvezeni iz TLexa te izrađena mrežna aplikacija rječnika. U okviru projekta predviđena je: 1. izradba temeljnoga rječnika od 10 000 natuknica; 2. izradba popratnih baza i njihovo povezivanje s temeljnim rječnikom; 3. povezivanje temeljnoga rječnika s drugim mrežnim izvorima koji se trenutačno izrađuju u Institutu za hrvatski jezik i jezikoslovlje (bazom glagolskih  valencija, kolokacija, hrvatskoga strukovnog nazivlja, Repozitorijem hratskih metafora, mrežnim stranicama Bolje je hrvatski (bolje.hr)); 4. izradba odostražnoga rječnika.MREŽNIK je zamišljen kao dinamični rječnik koji nakon završetka projektnoga razdoblja otvara mogućnost daljnjega dopunjivanja.]]></summary_hr><summary_en><![CDATA[As a part of the MREŽNIK (Croatian Online Dictionary) project, the online monolingual dictionary of Standard Croatian language with ten thousand dictionary entries will be compiled. The dictionary will be free, easy to search, it will allow interaction with users and will contain hypertext links. The dictionary entries will contain links to certain other words, expressions and repositories (Linguistic Advice Repository, Conjunction Repository, etc.). The dictionary will be corpus based (Croatian Language Repository and Croatian Web Corpus), but other sources, online and printed, will be taken into account when looking for example sentences and writing entry definitions.The dictionary will be compiled using TLex, a professional software application for compiling dictionaries. SketchEngine will be used to search the corpus. After the completion of the dictionary entries, the data will be exported from TLex, and the Web application will be developed.   The project will:1. compile the basic dictionary consisting of ten thousand entries;2. develope additional repositories and connect them with the basic dictionary; 3. connect the basic dictionary with other online resources which are currently being developed at the Institute of Croatian Language and Linguistics: (The Verb Valence Repository, The Collocation Repository, The Croatian Special Field Terminology of Croatian repository (Struna), The Etymological Dictionary of Croatian, The Croatian Metaphor Repository, website bolje.hr;4. compile a reverse dictionary.MREŽNIK is conceived as a dynamic dictionary, the development of which will not end at the end of the project.]]></summary_en></project><project>
<id>7319</id><title_hr><![CDATA[Izolacija i enkapsulacija bioaktivnih molekula samonikle i kultivirane koprive i komorača i učinci na fiziologiju organizma]]></title_hr><title_en><![CDATA[Isolation and encapsulation of bioactive molecules of wild and cultivated nettle and fennel and effects on organism physiology]]></title_en><user_id>1243</user_id><user_firstLast_name>Verica Dragović-Uzelac</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2018-01</proposal_call><code>IP-2018-01-4924</code><acronim><![CDATA[PlantBioPower]]></acronim><duration>01.11.2018 - 31.10.2022</duration><status>Završio</status><financ_value>199.084,21 eur</financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Prehrambena tehnologija, Poljoprivreda, Nutricionizam, </scie_field_hr><scie_field_en>Food technology, Agriculture, Nutrition, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prehrambeno-biotehnološki fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Food Technology and Biotechnology]]></institution_en><team_members_id>2644, 223, 2615, 1002, 1056, 1062, 1330, 3314, 23410, 3037, 23516, 5708, 25849, 855442, 13470, 3319, </team_members_id><team_members_names><![CDATA[Branka Levaj, IRENA LANDEKA JURČEVIĆ, Danijela Bursać Kovačević, Ivona Elez Garofulić, Zoran Zorić, Sandra Pedisić, Maja Repajić, Domagoj Đikić, Dyana Odeh, Igor Palčić, Sanja Radman, Ivanka Žutić, Valentina Kruk, Ena Cegledi, Marko Obranović, Nada Oršolić, ]]></team_members_names><keywords_hr><![CDATA[kopriva, komorač, bioaktivne molekule, biljni ekstrakti, eterična ulja, enkapsulacija, mikrobiom, mikotoksini]]></keywords_hr><keywords_en><![CDATA[nettle, fennel, bioactive molecules, plant extracts, essential oils, encapsulation, microbiome, mycotoxins]]></keywords_en><summary_hr><![CDATA[Kopriva (Urtica dioica L) i komorač (Foeniculum vulgare Mill) izvor su bioaktivnih molekula (BAM) (fitosteroli, karotenoidi, klorofili, terpenoidi, fenoli) smještenih u različitim dijelovima biljaka (nadzemni i podzemni). Rastu u prirodi kao samonikle ali se zbog postojanja brojnih kemotipova i varijabilnosti u kemijskom sastavu kultiviraju uz provođenje agrotehničkih mjera s ciljem dobivanja biljnog materijala ujednačene kvalitete.Zbog velikog broja BAM različitih molekulskih svojstava i farmakoloških učinaka (npr. antioksidacijsko, hipoglikemijsko, antivirusno, imunomodulacijsko djelovanje) mogu se koristiti u proizvodnji biljnih ekstrakata (BE) i eteričnih ulja (ETU) konvencionalnim te naprednim tehnikama ekstrakcije (npr. ASE; PHWE; MAE; SCO2 itd.). Dodatna stabilizacija BAM prisutnih u BE i ETU postiže se primjenom različitih postupaka enkapsulacije kojima se BAM inkorporiraju u zaštitni omotač nosača.Enkapsulacija omogućuje njihovu lakšu inkorporaciju u funkcionalne proizvode, naročito hidrofobnih i netopljivih molekula poput fitosterola, karotenoida, klorofila i sl. Također, BAM imaju značajan utjecaj na sastav mikrobioma crijeva te predstavljaju važan parametar u fiziološkoj modulaciji homeostaze organizma i osjetljivosti na bolesti.Stoga su ciljevi istraživanja:(i)definirati biološki potencijal samonikle koprive i komorača s različitih prirodna staništa te utvrditi utjecaj ishrane i agrotehničkih mjera na biosintezu BAM tijekom vegetacije; (ii)optimirati postupake proizvodnje BE i ETU te postupake enkapsulacije BE i ETU; (iii)odrediti djelovanje BAM koprive i komorača u prisutnosti mikotoksina na endogene probiotičke bakterije kolona, enzimsku aktivnost mikrobioma te posljedični tkivni i sistemski antioksidativni, antigenotoksični, metabolički, transkripcijski, upalni i imunosni odgovor domaćina; (iv)iznaći funkcionalne sastojake kao alternativni, ne-farmaceutski pristup u održavanju zdravlja i dobrobiti crijeva kroz promicanje crijevne mikrobne homeostaze.]]></summary_hr><summary_en><![CDATA[Nettle (Urtica dioica L.) and fennel (Foeniculum vulgare Mill) are rich source of bioactive molecules (BAM) (phytosterols, carotenoids, chlorophylls, terpenoids, phenols) located in different plant parts (over- and underground). They can be found as wild-grown, but because of a numerous chemotypes and variabilities, are being cultivated through various agrotechnical measures in order to obtain a uniform material. Due to the large number of BAMs of different properties and pharmacological effects (i.e. antioxidative, hypoglycemic, antiviral, immunomodulatory), they can be used for production of plant extracts (PE) and essential oils (EO) by conventional and novel extraction techniques (i.e. ASE; PHWE; MAE; SCO2 etc.). Their stabilization can be achieved by encapsulation where BAMs are incorporated into a protective wall material coating. Encapsulation provides easier incorporation of BAMs into functional products, especially for the hydrophobic ones (phytosterols, carotenoids, chlorophylls, etc.). Nevertheless, BAM have significant influence on the composition of intestinal microbiota and represent an important parameter in the physiological modulation of organism homeostasis and its susceptibility to diseases. Therefore, the aims of this research are to: (i) define the biological potential of wildf-grown nettle and fennel from different locations and to determine the influence of nutrition and agrotechnical measures on biosynthesis of BAM during vegetation; (ii) optimize PE and EO production and encapsulation procedures; (iii) determine the effect of nettle and fennel BAMs on endogenous probiotic colon bacteria in the presence of mycotoxins, microbial enzymatic activity and the consequent tissue and systemic antioxidative, antigenic, metabolic, transcriptional, inflammatory and immune response of the host; (iv) establish functional ingredients as an alternative, non-pharmaceutical approach to health care through promoting intestinal microbial homeostasis.]]></summary_en></project><project>
<id>7326</id><title_hr><![CDATA[Notch signaling in osteoclast progenitors induced by rheumatoid arthritis]]></title_hr><title_en><![CDATA[Notch signalni put u osteoklastnim progenitorima potaknutim reumatoidnim artritisom]]></title_en><user_id>3075</user_id><user_firstLast_name>Danka Grčević</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2018-01</proposal_call><code>IP-2018-01-2414</code><acronim><![CDATA[NORA]]></acronim><duration>01.12.2018 - 30.11.2022</duration><status>Završio</status><financ_value>132.722,81 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, Kliničke medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, Clinical sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb School of Medicine]]></institution_en><team_members_id>3895, 2978, 3882, 20922, 3604, 5107, 5110, 13283, 26491, 865162, 865435, </team_members_id><team_members_names><![CDATA[Alan Šućur, Vedran Katavić, Nataša Kovačić, Katarina Barbarić Starčević, Marina Ikić Matijašević, Zrinka Jajić, Ivo Kalajzić, Katerina Zrinski Petrovic, Masa Filipovic, Luka Minarik, Sara Aničić, ]]></team_members_names><keywords_hr><![CDATA[osteoclasts, arthritis, Notch, inflammation, progenitors, differentiation, cytokines, chemokines]]></keywords_hr><keywords_en><![CDATA[osteoklasti, artritis, Notch, upala, progenitori, diferencijacija, citokini, kemokini]]></keywords_en><summary_hr><![CDATA[Reumatoidni artritis karakteriziran je kroničnim upalnim odgovorom uz periartikularni i sustavni gubitak kosti uzrokovan pojačanom koštanom razgradnjom osteoklastima. S incidencijom od oko 1%, predstavlja značajan javnozdravstveni problem i pridonosi smanjenju kvalitete života. Osteokasti su velike multinuklearne stanice koje razgrađuju kost , a nastaju iz hematopoetskih stanica monocitno/makrofagne loze. Novije studije upućuju na moguću ulogu Notch signalnog puta u proliferaciji, diferencijaciji i migraciji stanica osteolastne loze. Međutim, točan mehanizam kako Notch signalni put djeluje u kontekstu artritisa nije poznat. Glavni cilj predloženog projekta je definirati ulogu Noch signalnog puta u proliferaciji, migraciji i diferencijaciji osteoklastnih progenitora u artritisu te testirati ima li manipulacija Notch signalnog puta učinak na aktivnost osteoklastnih progenitora i osteoresortivni potencijal.Korištenjem modela mišjeg artritisa izazvanog kolagenom (CIA) i uzoraka bolesnika s artritisom, cilj nam je razumjeti izražaj komponenti Notch sustava u pojedinim fazama tijekom diferencijacije osteoklasta i promjene izazvane artritisom, te učinke Notch-liganda na aktivnost osteoklastnih progenitora. Nadalje, planiramo testirati učinak inhibicije Notcha na proliferaciju, migraciju i diferencijaciju osteoklastnih progenitora in vitro. Kao in vivo model, primijenit ćemo neutralizacijska protutijela protiv Notcha i CreERT2 transgenične miševe u kojim će Notch signal biti inhibiran selektivno u osteoklastnim progenitorima koji izražavaju CX3CR1.Mišji CIA-model omogućit će praćenje i modulaciju razvoja bolesti uzrokovane pojačanom koštanom resorpcijom in vivo, dok će analiza ljudskih uzoraka omogućiti translaciju u kliničke uvjete. Karakterizacija Noch-signalnog puta u osteoklastnim progenitorima potaknutim artritisom pruža mogućnost razvoja terapijskih pristupa kojima će se kontrolirati njihova aktivnost, smanjujući time koštanu destrukciju uzorkovanu artritisom. ]]></summary_hr><summary_en><![CDATA[Rheumatoid arthritis (RA) is characterized by chronic inflammatory response as well as periarticular and generalized bone loss due to enhanced bone resorption by osteoclasts. With a prevalence of around 1%, it is an important contributor to public health burden and lower quality of life. Osteoclasts are large multinucleated bone-resorbing cells arising from monocyte/macrophage hematopoietic lineage. Recent evidences suggest the possible role of Notch signaling pathway in proliferation, differentiation and migration of osteoclast lineage cells. However, exact mechanism of how the Notch signaling works in the context of arthritis is largely unclear.The main goal of project proposal is to define the role of Notch signaling in osteoclast progenitor (OCP) proliferation, migration and differentiation in arthritis and to test if manipulation of Notch signaling has the effect on OCP activity and bone resorbing potential. Using the approach of mouse model of collagen-induced arthritis (CIA) and samples from arthritic patients, we aim to understand the stage specific expression of Notch system components during osteoclast differentiation and changes associated with arthritis, as well as the effects of Notch ligands on OCP activity. Furthermore, we plan to test the effect of Notch inhibition on OCP proliferation, migration and differentiation in vitro. As the in vivo model, we will utilize Notch inhibition by neutralizing antibodies and CreERT2 transgenic mouse model in which Notch signal is inhibited by tamoxifen injection selectively in CX3CR1-expressing OCPs.The mouse CIA model will enable us to monitor and modulate disease progression in the context of increased osteoresortion in vivo whereas the analysis of human samples will allow for the translation to the clinical settings. Characterization of Notch signaling in OCPs induced by arthritis could offer the potential to design therapeutic approaches to control their activity thus limiting bone destruction in arthritis.]]></summary_en></project><project>
<id>7328</id><title_hr><![CDATA[Zbrinjavanje mulja kroz proizvodnju energetskih kultura]]></title_hr><title_en><![CDATA[Sludge management via energy crops’ production]]></title_en><user_id>5606</user_id><user_firstLast_name>Neven Voća</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2018-01</proposal_call><code>IP-2018-01-7472</code><acronim><![CDATA[Mud4BioEnergy]]></acronim><duration>01.11.2018 - 31.10.2022</duration><status>Završio</status><financ_value>126.915,00 eur</financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Poljoprivreda, Biotehnologija, </scie_field_hr><scie_field_en>Agriculture, Biotechnology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Agronomski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Agriculture]]></institution_en><team_members_id>20300, 4927, 19006, 23630, 5608, 5589, 5600, 5604, 19643, 858338, 25226, 865134, </team_members_id><team_members_names><![CDATA[Milan Poljak, Tomislav  Karažija, Josip Leto, Hrvoje Kutnjak, Nikola Bilandžija, Tajana Krička, Vanja Jurišić, Ana Matin, Mateja Grubor, Jona Šurić, Anamarija Peter, Ivan Brandić, ]]></team_members_names><keywords_hr><![CDATA[Primjena mulja, energetske kulture, prinos, žetva, biogoriva]]></keywords_hr><keywords_en><![CDATA[Sludge application, energy crops,  yield,  harvest, biofuels]]></keywords_en><summary_hr><![CDATA[Prioritetna politika Europske unije jest da se mulj dobiven nakon pročistača otpadnih voda koristi na ekonomski optimalan način u poljoprivrednom sektoru te da se ukoliko je to moguće izbjegne njegovo spaljivanje. Zbrinjavanje mulja u poljoprivredi je definirano strogim propisima i direktivama koje nisu razdvojile njegovo korištenje u prehrambenoj ili neprehrambenoj proizvodnji. Postoje velike mogućnosti za napredak u isplativosti efikasne primjene mulja na tlo i to u količinama koje su veće od definiranih, bez ikakve opasnosti i mogućeg prodora štetnih tvari u okoliš. Naime, Pravilnikom o primjeni mulja u poljoprivrednoj proizvodnji u RH propisana je količina od najviše 1,66 tona suhe tvari mulja godišnje po hektaru poljoprivrednog zemljišta, bez obzira na vrstu poljoprivredne proizvodnje. Međutim, unatoč tim ograničenjima, kroz korištenje energetskih kultura postoji mogućnost obilnijeg korištenja mulja kao gnojiva. Procjene govore da bi se na taj način poljoprivredne površine višestruko reducirale u smislu intenzivnijeg zbrinjavanja mulja u poljoprivredi. Isto tako, idealno bi se korištenje mulja uklopilo upravo u proizvodnju energetskih kultura, koje bi bile oslobođene problema sa zdravstvenom reputacijom proizvoda. Ovom metodom mogla bi se iskoristiti tla lošije kvalitete i nepovoljnih agroklimatskih uvjeta koja ne mogu konkurirati u konvencionalnoj proizvodnji hrane. Zbog svega navedenog, kao idealne energetske kulture se nameću sterilna rizomatska trava Miscanthus x giganteus i biljka iz porodice sljezova Sida hermaphrodita. Cilj ovoga istraživanja analiza je biomase navedenih energetskih kultura, gnojenih različitim količinama mulja iz pročistača otpadnih voda, jednako u energetskom i ekološkom smislu. Isto tako, veliki izazov u uzgoju energetskih kultura leži u pravilnom odabiru datuma žetve, a samim time i smjeru korištenja biomase za potrebe proizvodnje različitih biogoriva.]]></summary_hr><summary_en><![CDATA[EU priority policy is a feasible utilization of sludge from wastewater treatment plant in the agricultural sector while avoiding its incineration. Sludge disposal in the agricultural sector is defined by strict regulations and directives which do not distinguish its utilization in food or non-food production. There is a great potential for improvement in terms of efficient sludge application to the soil, in larger quantities, without any danger or possible breaking of harmful substances into the environment. Regulations on the sludge application in agricultural production in Croatia is regulated by the amount of up to 1.66 t of sludge DM/year per ha of arable land, regardless of the type of agricultural production. However, despite these limitations, through the use of energy crops, there is a possibility of plentiful sludge use as a fertilizer. According to estimations, arable land will be greatly reduced in terms of intensive sludge management in agriculture in this way. Ideally, the use of sludge would fit right in the production of energy crops, which would be exempt from the problems with the healthy reputation of the product. Furthermore, this method could be used in lower quality soils and unfavorable climatic conditions that cannot compete with conventional food production. Consequently, sterile grass Miscanthus x giganteus and Mallow family plant Sida hermaphrodita are imposed as deal energy crops. The aim of this research is the analysis of those energy crops, fertilized with various quantities of sludge from the wastewater treatment plant. Also, a major challenge in energy crops growing lies in the proper selection of the harvesting date, as well as in choosing the optimal biofuel production pathway. ]]></summary_en></project><project>
<id>7329</id><title_hr><![CDATA[Klinički biomarkeri atopijskog dermatitisa]]></title_hr><title_en><![CDATA[Clinical biomarkers of atopic dermatitis]]></title_en><user_id>7190</user_id><user_firstLast_name>Branka Marinovic</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2018-01</proposal_call><code>IP-2018-01-5978</code><acronim><![CDATA[ADBIOMARK]]></acronim><duration>01.03.2019 - 28.02.2023</duration><status>Prekinut</status><financ_value>136.040,88 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo, Prirodne znanosti, </scie_area_hr><scie_area_en>Biomedicine and health sciences, Natural sciences, </scie_area_en><scie_field_hr>Kliničke medicinske znanosti, Kemija, </scie_field_hr><scie_field_en>Clinical sciences, Chemistry, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb School of Medicine]]></institution_en><team_members_id>1261, 23634, 23524, </team_members_id><team_members_names><![CDATA[Ivone Jakaša, Suzana  Ljubojevic Hadzavdić, Ružica Jurakić Tončić, ]]></team_members_names><keywords_hr><![CDATA[atopijski dermatitis, imunološki biomarkeri, biomarkeri kožne barijere, filagrinske mutacije, molekularno profiliranje, prediktivni modeli]]></keywords_hr><keywords_en><![CDATA[atopic dermatitis, immunological biomarkers, biomarkers of skin barrier, filaggrin mutations, molecular profiling, predictive models]]></keywords_en><summary_hr><![CDATA[Atopijski dermatitis (AD) vrlo je česta kožna bolest s prevalencijom u djece od 15-30%, a u odraslih od 2-10%. Etiologija AD-a samo je dijelom razjašnjena, smatra se da bolest nastaje interakcijom okolišnih i genetskih čimbenika što dovodi do imunoloških poremećaja i oštećenja funkcije kožne barijere. Još uvijek ne možemo izliječiti bolesnike s AD, već bolest možemo držati pod kontolom ublažavanjem simptoma i produljavanjem razdoblja remisije. Trenutno ne postoji klasifikacija bolesti temeljem koje se može odrediti koji oblik terapije primijeniti, već se nakon provedene procjene težine bolesti u liječenju koristi višestepeni pristup što dodatno opterećuje kvalitetu života bolesnika ali i resurse našeg zdravstva. Glavni je cilj ove prospektivne kliničke studije identificirati biomarkere koji bi mogli biti od koristi za objektivnu procjenu težine bolesti i predviđanje odgovora na terapiju. Studija ce uključiti široki spektar genetskih i molekularnih čimbenika koji doprinose promjenama u kožnoj barijeri i imunološkom odgovoru kod AD-a. Istraživanje će biti usmjereno na neinvanzivne biomarkere koji se određuju u stratum corneumu (SC) koji će biti prikupljen pomoću adhezivnih traka. Biomarkeri iz SC omogućuju dobivanje informacija o kožnoj barijeri i imunološkim promjenama u koži, a, predstavljaju ciljne točke u liječenju primjenom lokalne i sistemske terapije. Značaj predložene studije je u tome što će uključiti široki raspon biomarkera relevantnih za patofiziologiju  AD-a određivanih u velikoj kohorti klinički dobro definiranih pacijenata s AD-om koje će se  prospektivno pratiti tijekom terapije. Biomarkeri bazirani na kliničkim, genetskim ili biokemijskim obilježjima doprinijeli bi objektivnosti i točnijoj procjeni aktivnosti bolesti, a time i podjelu u homogenije podgrupe s ciljem boljeg, individualnog pristupa u liječenju pacijenata sa AD-om što bi rezultiralo optimalnim omjerom koristi i rizika za bolesnika, ali i za zdravstveni sustav.]]></summary_hr><summary_en><![CDATA[Atopic dermatitis (AD), is the most prevalent skin disease with the life-time prevalence ranging between 15-30 % in children and 2-10 % in adults. Etiology of AD remains only partly understood but is believed to be multifactorial, most likely rooted in a complex interaction between environmental and genetic factors leading to immune deviation and impaired barrier function. At present AD cannot be cured and disease management is focused on improvement of symptoms and achievement of long-term disease control. With exception of disease severity which itself is challenging to quantify, at present there is no classifications which might be used to support decision on the type of therapy, and a multistep approach is followed imposing additional burden for patient’s quality of life and health care resources. The main objective of this prospective clinical study is to identify genetic, immunological and skin barrier biomarkers that can predict disease severity and treatment response in patients with AD. The focus will be on non-invasive biomarkers determined in the uppermost layer of the skin, stratum corneum (SC) collected by adhesive tapes. SC biomarkers also provide information on local immune milieu and skin barrier, both known as key components in AD pathophysiology as well as treatment targets for topical and systemic therapies. The strength of the proposed study is that it will include a wide range of biomarkers relevant for AD pathophysiology, which will be determined in a large cohort of clinically well-defined AD patients who will prospectively be followed during the therapy. Biomarkers based on clinical, genetic or biochemical features would enable more objective and accurate assessment of disease activity and furthermore stratification into more homogeneous subgroups aiming at personalized approach in treatment of AD with an optimal benefit/risk ratio for the patient and health care system.]]></summary_en></project><project>
<id>7330</id><title_hr><![CDATA[Temeljna elektronska svojstva novih kvantnih materijala: bezmaseni i korelirani fermion]]></title_hr><title_en><![CDATA[Fundamental electronic properties of new quantum materials: massless and correlated fermions]]></title_en><user_id>5009</user_id><user_firstLast_name>Ivan Kokanović</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2018-01</proposal_call><code>IP-2018-01-8912</code><acronim><![CDATA[FEPNQMMCF]]></acronim><duration>01.10.2018 - 28.02.2023</duration><status>Završio</status><financ_value>132.722,81 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, </scie_field_hr><scie_field_en>Physics, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>1173, 3227, 17743, 23130, 6713, 4814, </team_members_id><team_members_names><![CDATA[Mario Novak, Mirko Baćani, Filip Orbanić, Bruno Gudac, Cooper John Robert, Zvonko Glumac, ]]></team_members_names><keywords_hr><![CDATA[Supravodljivost, bezmaseni i korelirani fermioni, topološki izolatori, Diracovi polumetali, Weyl polumetali]]></keywords_hr><keywords_en><![CDATA[Superconductivity, massless and correlated fermions, Topological insulators, Dirac semimetal, Weyl semimetal]]></keywords_en><summary_hr><![CDATA[U ovom projektu želimo primijeniti našu stručnost trendovima u fizici kondenzirane materije koji povezuju temeljna istraživanja s suvremenim tehnološkim razvojem. Stoga smo odabrali teme koje se bave električnim transportom, magnetskim, termoelektričnim kao i strukturnim i termodinamičkim svojstvima topoloških izolata, TI, Dirac i Weyl semimetal, DSM i WSM,  i supravodiči (visokotemperaturni kupratni supravodiči, VTS, i konvencionalni poremećeni supravodiči). Predloženi projekt nudi sveobuhvatna istraživanja od sinteze uzorka do interpretacije eksperimentalnih rezultata istraživanja. Cilj je proučiti kako se različiti parametri sinteze tih materijala odnose na njihove nanostrukturalne detalje i elektronske korelacije.   U području TI, DSM, WSM   će se sintetizirati novi materijali koje možemo koristiti za daljnje istraživanje i za suradnju s drugim znanstvenim grupama.  Rezultati u visokom magnetskom polju upućuju na snažne korelacijske efekte u ZrSiS-u, stoga pažljivom manipulacijom ove familije materijala kroz istraživanja učinka dopiranja, očekujemo da će se otkriti novi kvantni fazni prijelazi povezani s topološkom čvorom petljom, korelirani efekti  i  uređena stanja fermiona. U području tipa II Weylovih polumetala očekujemo uspješne sinteze visoko kvalitetnih monokristala nekoliko članova obitelji TaIrTe4, ugađanjem kompozicije, Fermijeva energija će se pomaknuti i omogućiti nam da promatramo svojstva ovih materijala. U polju VTS, primarni problem koji se želi riješiti u ovom projektu je postojanje elektronskih džepova u niskim magnetskim poljima uzrokovanih valovima gustoće naboja (CDW), u čistim YBa2Cu3O6+x monokristalima. Želimo istražiti termodinamičke dokaze CDW i magnetskih faznih prijelaza.  Konačno, poseban naglasak istraživanja će biti posvećen daljnjem razvoju novih metoda mjerenja specifične topline i magnetizacije na malim monokristalima koji su često najviše kvalitete. ]]></summary_hr><summary_en><![CDATA[In this project, we want to apply our expertise to the trends in condensed matter physics which link fundamental research with contemporary technological development. We have therefore selected topics that address electrical transport, magnetic, thermoelectric as well as structural, and thermodynamic properties, of topological insulators, TI,  Dirac and Weyl semimetals, DSM, WSM and superconductors (high-temperature cuprate superconductors, HTSC, and conventional disordered superconductors).  The proposed Project offers comprehensive research from sample synthesis to the interpretation of the experimental research results. The aim is to study how various parameters of synthesis of these materials relate to their nanostructural details and electronic correlations.In field of TI, DSM, WSM a useful new material will be synthesized which we can use for further study and for collaboration with other groups. The results in high magnetic field suggest that strong correlation effects are indeed present in ZrSiS, and with careful manipulation of this system through doping studies, novel transitions associated with the topological nodal loop may be realized as well as correlated fermion effects and ordered states will be revealed. In the field of type-II Weyl semimetals we expect to get high-quality single crystals of several members of TaIrTe4 family, by tuning the composition, the Fermi energy will be shifted and allow us to observe the material properties. In the field of HTSC, the primary issue addressed in this project is the existence of electron pockets in low magnetic fields caused by charge density waves (CDW) in pure YBa2Cu3O6+x single crystals. At the same time we will look for thermodynamic signatures of the CDW and magnetic phase transitions. Finally, a particular emphasis of the research will be the further development of novel apparatus to measure the specific heat and magnetisation of small single crystals which are often of the highest quality.   ]]></summary_en></project><project>
<id>7337</id><title_hr><![CDATA[Diofantska geometrija i primjene]]></title_hr><title_en><![CDATA[Diophantine geometry and applications]]></title_en><user_id>3767</user_id><user_firstLast_name>Matija Kazalicki</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2018-01</proposal_call><code>IP-2018-01-1313</code><acronim><![CDATA[DIOPHANT]]></acronim><duration>12.10.2018 - 11.10.2022</duration><status>Završio</status><financ_value>123.468,71 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Matematika, </scie_field_hr><scie_field_en>Mathematics, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>95, 1262, 1264, 23916, 23830, 1312, 1267, 1348, 2990, 4086, 1251, 23950, 23281, 23964, 23962, 23763, 2910, 17746, 865211, </team_members_id><team_members_names><![CDATA[Andrej Dujella, Alan Filipin, Ana Jurasić, Goran  Drazic, Daniel Kohen, Sanda Bujačić Babić, Ivica Gusić, Ivan Soldo, Tomislav Pejković, Nikola Adžaga, Petra Tadić, Ivan Krijan, Vinko Petričević, Antonela Trbović, Tomislav Gužvić, Bartosz Naskrecki, Filip Najman, Marija Bliznac Trebješanin, Petar Orlić, ]]></team_members_names><keywords_hr><![CDATA[Diofantove m-torke, eliptičke krivulje, modularne forme, Diofantske aproksimacije, kriptografija]]></keywords_hr><keywords_en><![CDATA[Diophantine m-tuples, elliptic curves, modular forms, Diophantine approximations, cryptography]]></keywords_en><summary_hr><![CDATA[Predloženi projekt će koordinirati i podržati istraživačke aktivnosti hrvatske grupe iz teorije brojeva. Teme istraživanja su: Diofantove m-torke i primjene, diofantske aproksimacije (separacija korijena, p-adski verižni razlomci), eliptičke krivulje i modularne forme. Nedavno su Dujella, Kazalicki, Mikić i Sziksai pokazali da postoje beskonačno mnogo racionalnih Diofantovih šestorki, te riješili problem koji je bio otvoren još od vremena Eulera. Planiramo proučiti geometriju tih šestorki kako bi utvrdili postojanje racionalnih Diofantovih sedmorki. Ti će rezultati biti korišteni za konstrukciju familija eliptičkih krivulja visokog ranga i fiksne torzije. Važan alat za proučavanje Mordell-Weil grupa je algoritam za injektivnost preslikavanja specijalizacije koju su razvili Gusić i Tadić koje namjeravamo generalizirati. Planiramo dokazati neke posebne slučajeve slutnje o regularnosti Diofantovih četvorki i proučavati taj fenomen u parametarskim familijama. Također ćemo razmotriti generalizacije na prstenove cijelih brojeva u poljima kao i općenitije D (n) -m-torke. Freitas, Le Hung i Siksek su nedavno dokazali da su sve eliptičke krivulje nad realnih kvadratnim poljima modularne. Planiramo proučavati modularnost na potpuno realnim kubnim poljima. Kazalicki i Kohen nedavno su otkrili vezu između ranga eliptičnih krivulja i nultočki pridruženih modularnih formi (mod p). Planiramo ovo dalje proučiti i povezati s rezultatima Mazur i Swinnerton-Dyer o analitičkom rangu eliptičkih krivulja. Najpopularniji kriptosustav s javnim ključem danas u upotrebi je RSA. Proučavajući diofantske aproksimacije planiramo razviti neke učinkovite napade na ovaj kriptosustav. Rezultati istraživanja bit će objavljeni u uglednim časopisima i predstavljeni na međunarodnim konferencijama. Ovim će se projektom produbiti naše znanstvene veze s međunarodnim grupama iz teorije brojeva te uvesti mlade znanstvenike u istraživanje.]]></summary_hr><summary_en><![CDATA[The proposed project will coordinate and support research activities of Croatian number theory group. The topics of research are: Diophantine m-tuples and applications, Diophantine approximations (root separation, p-adic continued fractions), elliptic curves and modular forms. Recently, Dujella, Kazalicki, Mikić and Sziksai showed that there are infinitely many rational Diophantine sextuples, and solved the problem that was open from the time of Euler. We plan to study the geometry of these sextuples to determine the existence of rational Diophantine septuplets. These results will be used for the construction of families of elliptic curves of high rank and fixed torsion. An important tool for studying Mordell-Weil groups is the algorithm for the injectivity of the specialization map developed by Gusić and Tadić which we plan to generalize. We plan to prove some special cases of regularity conjecture for Diophantine quadruples, and to study it in parametric families. Also, we will consider generalisations to the rings of integers of number fields, and to more general D(n)-m-tuples. Freitas, Le Hung and Siksek recently proved that all elliptic curves over real quadratic fields are modular. We plan to study the modularity over totally real cubic fields. Kazalicki and Kohen recently discovered the connection between the ranks of elliptic curves and zeros of associated modular forms (mod p). We plan to study this further, and connect it to the results of Mazur and Swinnerton-Dyer on the analytic rank of elliptic curves. The most popular public key cryptosystem in use today is the RSA. Studying Diophantine approximations, we plan to develop some efficient attacks on this cryptosystem. The results of the research will be published in respectable journals and presented on international conferences. Through this project we will intensify our scientific connections with international number theory groups and introduce young researchers to the research in number theory.]]></summary_en></project><project>
<id>7341</id><title_hr><![CDATA[Metabolomski pristupi u otkrivanju novih biomarkera i dubinska fenotipizacija u bolestima bubrega i srca pasa]]></title_hr><title_en><![CDATA[Metabolomic approaches to novel biomarker discovery and deep phenotyping in kidney and cardiac diseases of dogs]]></title_en><user_id>801</user_id><user_firstLast_name>Vladimir Mrljak</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2018-01</proposal_call><code>IP-2018-01-8324</code><acronim><![CDATA[MetaDog]]></acronim><duration>12.11.2018 - 11.11.2022</duration><status>Završio</status><financ_value>126.020,31 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Veterinarska medicina, </scie_field_hr><scie_field_en>Veterinary medicine, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Veterinarski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Veterinary Medicine]]></institution_en><team_members_id>23757, 2779, 19047, 2720, 23647, 6734, 6678, 24078, 19049, 5882, 6338, 6240, 6965, 25377, </team_members_id><team_members_names><![CDATA[Andrea Tumpa, Anita  Horvatić, Guillemin Nicolas, Blanka  Beer Ljubić, David Eckersall, Josipa Kuleš, Martina Crnogaj, Burchmore Richard, Asier Galan, Alan Kovacevic, Jose Ceron, Jelena Gotić, Renata Barić Rafaj, Ivana Rubić, ]]></team_members_names><keywords_hr><![CDATA[ Metabolomika, Biomarkeri, Bubreg, Srce, Pas   ]]></keywords_hr><keywords_en><![CDATA[ Metabolomics, Biomarkers, Kidney, Heart, Dog]]></keywords_en><summary_hr><![CDATA[Metaboliti u serumu ili urinu mogu predstavljati biomarkere u otkrivanju bolesti, često i prije razvoja bolesti. Metabolomikom se identificiraju promijenjeni metaboliti u krvi i urinu. Vrlo malo istraživanja provedeno je na psima u cilju procjene potencijala metabolomike u dijagnostici. Metabolomskim pristupom će se istražiti metaboliti kao biomarkeri, u dvije česte i teške bolesti pasa: (a) protozoarnu bolest - babezioza s komplikacijom akutne ozljede bubrega (AKI) i (b) idiopatsku dilatacijsku kardiomiopatiju (iDCM).Ciljevi projekta su: otkrivanje novih biomarkera poremećaja funkcije bubrega i srca primijenom metabolomskih tehnika u analizi seruma i urina pasa s (a) nekompliciranim i kompliciranim oblikom babezioze,  (b) dijagnozom iDCM; određivanje učinka terapije Imizol u na metabolite u babeziozi; bolje razumijevanje  signalizacijski puteva u patogenezi ovih bolesti;  korištenje individualiziranih metaboličkih otisaka u terapiji prilagođenoj pacijentu.Napredne &#39;&#39;omika&#39;&#39; metode, tekućinska kromatografija, masena spektrometrija (LC-MS / MS) i plinska kromatografija (GC) -MS kombinirat će se s inovativnim metodama bioinformatike i biostatistike u dubinskoj analizi (dubinska fenotipizacija), obradom mnogobrojnih metabolomskih podataka.  Očekuje se da će rezultati pridonijeti    (a) identifikaciji promjena metabolita u infekciji  B. canis kao i novih biomarkera AKI i (b) ranoj dijagnostici  iDCM kod pasa, pri čemu će identificirani biomarkeri pridonijeti individualiziranom liječenju pacijenata. Metabolomika će pridonijeti razvoju veterinarske kliničke medicine prepoznavanjem novih biomarkera i terapijskih ciljeva lijekova, te doprinijeti širenju upotrebe ove metode u veterinarskoj medicini u Hrvatskoj. Znanstveni rezultati poboljšat će dijagnozu, prognozu i terapiju babezioze i iDCM-a. Dugoročno, uvođenje metabolomike u kliničku medicinu Veterinarski fakultet će se profilirati kao vodeća ustanova u &#39;&#39;omika&#39;&#39; područjima istraživanja na prostorima jugoistočne Europe.]]></summary_hr><summary_en><![CDATA[Metabolites in serum or urine are can act as biomarkers, detecting disease often before the development of illness. Metabolomics, identifies altered metabolites in blood and urine. In the dog there have been few investigations to assess the potential of metabolomics in diagnosis. Here a metabolomic approach will investigate metabolite biomarkers in two common and serious diseases of dogs; (a) the infectious disease of Babesiosis and acute kidney injury (AKI) and (b) non-infectious idiopathic dilated cardiomyopathy (iDCM). The goals of the project are to discover novel biomarkers of kidney and cardiac malfunction by metabolomics analysis of the sera and urine of dogs with (a) uncomplicated and complicated form of babesiosis, as well (b) dogs with diagnosed iDCM; to determine the effect of therapy for Babesiosis with the ImizolR, on metabolites; to understand pathway signalling in pathogenesis of these diseases; to use individual metabolomics fingerprints in tailored therapy. Advanced omics methods of liquid chromatography and mass spectrometry (LC-MS/MS) and gas chromatography (GC)-MS will be combined with innovative bioinformatics and biostatistics methods for in depth analysis (deep phenotyping) of the the rich metabolomics data from MS platforms.The results are expected to identify (a) metabolite change from B. canis infection and novel biomarkers of AKI and (b) early diagnosis of iDCM in dogs. Identified biomarkers will yield personalization of individual patient’s treatment. The impact of metabolomics will enhance veterinary clinical medicine by identification of biomarkers and therapeutic drug targets, spearheading the use of metabolomics in veterinary medicine in Croatia. The scientific results will improve the diagnosis, prognosis and therapy of babesiosis and iDCM.  For the long-term, introduction of metabolomics into clinical veterinary medicine will consolidate the Faculty of Veterinary Medicine as the leader in veterinary -omics research in SE Europe]]></summary_en></project><project>
<id>7342</id><title_hr><![CDATA[Monitoring rezistentnosti štetnika: nove metode detekcije i učinkovite strategije upravljanja rezistentnošću]]></title_hr><title_en><![CDATA[]]></title_en><user_id>12674</user_id><user_firstLast_name>Renata Bažok</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-01</proposal_call><code>DOK-2018-01-2824</code><acronim><![CDATA[MONPERES]]></acronim><duration>02.07.2018 - 31.12.2022</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Poljoprivreda, </scie_field_hr><scie_field_en>Agriculture, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Agronomski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Agriculture]]></institution_en><team_members_id>24311</team_members_id><team_members_names><![CDATA[ Doktorand: Martina Kadoić Balaško ]]></team_members_names><keywords_hr><![CDATA[biotest, metode detekcije, genetski monitoring, geometrijsko morfometrijska analiza, rezistentnost štetnika, upravljanje rezistentnošću]]></keywords_hr><keywords_en><![CDATA[ bioassay, detection methods, genetic monitoring, geometric morphometric analyse, pest resistance, restitance management strategies                   ]]></keywords_en><summary_hr><![CDATA[Proizvodnju važnih kultura u Hrvatskoj (kukuruz, krumpir i jabuka) ugrožavaju brojni štetnici, od kojih su najvažniji kukuruzna zlatica (Diabrotica virgifera virgifera LeConte) (WCR), krumpirova zlatica (Leptinotarsa decemlineata Say) (CPB) i jabukov savijač (Cydia pomonella L.) (CM). Navedene vrste razvile su rezistentnost na insekticide ili na strategije suzbijanja. Sustavno praćenje rezistentnosti štetnika u Hrvatskoj ne postoji. Za dokazivanje rezistentnosti uobičajeno se koriste biotestovi, biokemijski i molekularni testovi koji imaju određene prednosti, ali i nedostatke.Opći cilj predloženog projekta je otkriti i pratiti rezistentne populacije štetnika u Hrvatskoj, optimizirati genetske metode i istražiti pouzdanost geometrijsko-morfometrijskih metoda u otkrivanju rezistentnosti, te održati učinkovito suzbijanje uporabom odgovarajućih antirezistentnih strategija usmjerenih na najvažnije štetnike ratarskih (WCR, CPB) i voćarskih (CM) kultura.Specifični ciljevi projekta su:O1) u poljskim uvjetima Hrvatske organizirati sustavni monitoring rezistentnosti CPB i CM; O2) optimizirati genetske metode za otkrivanje varijabilnosti povezanih s razvojem rezistentnosti WCR, CPB i CM;O3) istražiti mogućnost korištenja geometrijsko-morfometrijskih metoda za otkrivanje razvoja rezistentnosti istraživanih štetnika;O4) utvrditi mogućnost korištenja alternativnih metoda suzbijanja; O5) osigurati prijenos znanja i spoznaja do ključnih interesnih skupina. Očekivani rezultati: R1) osigurani pouzdani podaci o pojavi i distribuciji rezistentnih populacija CPB i CM u Hrvatskoj; R2) istražene, razvijene i optimizirane genetske i R3) geometrijsko-morfometrijske metode za otkrivanje i praćenje nerezistentnih i rezistentnih populacija CPB, WCR i CM; R4) osigurani podaci o alternativnim (uključujući nekemijske) metodama i strategijama suzbijanja i R5) stečena znanja i spoznaje predočene interesnim skupinama. Osigurana potpora provedbi novo razvijenih strategija u poljoprivrednu praksu.]]></summary_hr><summary_en><![CDATA[The production of the important crops, maize, potato and apples in Croatia is endangered by many of insect pests out of which very important are Western corn rootworm (Diabrotica virgifera virgifera LeConte) (WCR), Colorado potato beetle (Leptinotarsa decemlineata Say) (CPB) and Codling moth (Cydia pomonella L.) (CM). These pests have shown resistance to insecticides or to management strategies. No systematic monitoring of pest resistance is carried out in Croatia. Methods available for resistance detection  (bioassays, biochemical or molecular) have positive and negative points. The main objective is to detect and monitor the resistant variants in Croatia, optimize genetic and explore reliability of morphometric based survey techniques for the detection of resistance, and to maintain effective control using appropriate resistance manageemnt strategies of WCR, CPB and CM. Specific objectives are: O1) to conduct systematic field monitoring of resistance in CPB  and CM in Croatia; O2) to optimize techniques to detect genetic differentiation correlated with resistance development in WCR, CPB and CM; O3) to explore the potential of geometric morphometric techniques in order to detect resistance development in investigated pests;O4) to establish the potential for use of alternative control options for investigated pests.O5) to disseminate gained knowledge to key stakeholders The expected results are: R1 provided reliable data on the presence and distribution of resistant variants of CPB and CM in Croatia; R2) The genetic and R3) morphometric based survey techniques to detect and monitor the movement of non-resistant and resistant variants of CPB, WCR and CM explored, developed and optimized; R4) the summarized information on alternative (including non-chemical) control options and strategies provided and R5) The gained knowledge disseminated to key stakeholders. Provided support to implementation of newly developed strategies into the agricultural practice.]]></summary_en></project><project>
<id>7343</id><title_hr><![CDATA[Metodološki okvir za učinkovito upravljanje energijom s pomoću inteligentne podatkovne analitike]]></title_hr><title_en><![CDATA[]]></title_en><user_id>6717</user_id><user_firstLast_name>Dario Šebalj</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-01</proposal_call><code>DOK-2018-01-5414</code><acronim><![CDATA[MERIDA]]></acronim><duration>24.09.2018 - 31.01.2025</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Ekonomija, </scie_field_hr><scie_field_en>Economy, </scie_field_en><institution_hr><![CDATA[Sveučilište Josipa Jurja Strossmayera u Osijeku, Ekonomski fakultet u Osijeku]]></institution_hr><institution_en><![CDATA[Josip Juraj Strossmayer University of Osijek, Faculty of Economics]]></institution_en><team_members_id>25355</team_members_id><team_members_names><![CDATA[ Doktorand: Marinela Knežević ]]></team_members_names><keywords_hr><![CDATA[podatkovna analitka, strojno učenje, energetska učinkovitost, troškovi energije, lanac opskrbe, simulacije, metodološki okvir]]></keywords_hr><keywords_en><![CDATA[data analytics, machine learning, energy efficiency, energy cost, energy supply chain, simulation, methodological framework]]></keywords_en><summary_hr><![CDATA[Iako u Hrvatskoj i u drugim zemljama EU postoje strategije i nacionalni planovi energetske učinkovitosti kojima se određuju i prate ciljevi smanjenja potrošnje energije,  podaci se nedovoljno znanstveno analiziraju u svrhu učinkovitijeg upravljanja energijom, a posebice nedostaje uporaba metoda strojnog učenja. Upravo je svrha projekta provesti inteligentnu analizu podataka o energetskoj učinkovitosti zgrada u javnom sektoru, ponuditi metode i modele koji bi omogućili bolje planiranje nacionalne energetske politike te upravljanje troškovima. Ciljevi projekta su: (1) identificirati karakteristične skupine (klastere) javnih zgrada za koje se prate energetske karakteristike, mjere za poboljšanje tih karakteristika i potrošnja energije, (2) uporabom podatkovne analitike razviti metodološki okvir za  predviđanja i analizu utjecaja pojedinih varijabli na uštede u potrošnji energije, emisiji CO2 i troškovima, (3) naprednim analitičkim metodama procijeniti financijsku isplativost i dugoročne financijske učinke mjera za povećanje energetske učinkovitosti i (4) simulacijskim modeliranjem predložiti prilagodbe modela lanca opskrbe prirodnog plina kao jednog od važnijih energenata u javnom sektoru. Za dobivanje modela testirat će se metode strojnog učenja, kao što su klaster analize, neuronske mreže, stabla odlučivanja, metoda potpornih vektora i druge, zatim financijske metode, mapiranje lanca opskrbe i simulacijsko modeliranje. Statističkim testovima izabrat će se metode koje generiraju preciznije modele i predložiti njihova integracija u nov metodološki okvir kao znanstveni doprinos projekta.  Osim toga, otkrit će se utjecaj pojedinih ulaznih varijabli na potrošnju energije i trošak te stvoriti jedinstvena baza podataka energetske učinkovitosti koja će služiti i za buduće analize. Osim istraživača, korisnici ovog projekta mogu biti državne institucije davatelji subvencija, donositelji i provoditelji energetske politike, korisnici zgrada i pružatelji energetskih usluga.]]></summary_hr><summary_en><![CDATA[Although there are strategies and national plans of energy efficiency in Croatia and other EU countries, which determine and monitor the objectives of reducing energy consumption, the data have not been scientifically analyzed enough for the purpose of efficient energy management, and there is a lack of machine learning methods usage.  The purpose of the project is to conduct an intelligent data analysis on public buildings energy efficiency, and to suggest methods and models that will enable better planning of national energy policy. The aims of the project are: (1) to identify characteristic clusters of public buildings for which data on energetic characteristics, measures for improving those characteristics, and energy consumption are captured, (2) to develop a methodological framework for predictions and analyses of variable influence on energy consumption, CO2 emission and cost, by using intelligent data analytics,  (3) to estimate financial compensation and long-term financial effects of measures for increasing energy efficiency by advanced analytical methods, and (4) to suggest improvements in supply chain of natural gas as one of the important energy sources in building sector. In order to obtain models, methods of machine learning will be tested such as cluster analysis, neural networks, decision trees, support vector machines, and others, as well as financial methods, supply chain mapping, and simulation modelling.  By using statistical tests, the more successful methods will be suggested for integration in the methodological framework that will be the major scientific contribution. In addition, the influence of specific input variables on energy consumption and cost will be revealed, and a unique database of energy efficiency will be established that could be used for future data analyses. Besides researchers, the users of this project could be state institutions providers of subventions, policy makers, managers in public sector, and energy providers.]]></summary_en></project><project>
<id>7345</id><title_hr><![CDATA[Napredni nositelji energije u oporabi plastičnog otpada]]></title_hr><title_en><![CDATA[Smart energy carriers in recovery of plastic waste]]></title_en><user_id>2536</user_id><user_firstLast_name>Daniel Rolph Schneider</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2018-01</proposal_call><code>IP-2018-01-3200</code><acronim><![CDATA[NEOPLAST]]></acronim><duration>01.01.2019 - 31.12.2022</duration><status>Završio</status><financ_value>132.617,64 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Interdisciplinarne tehničke znanosti, Kemijsko inženjerstvo, Strojarstvo, </scie_field_hr><scie_field_en>Interdisciplinary technological sciences, Chemical engineering, Mechnical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet strojarstva i brodogradnje]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Mechanical Engineering and Naval Architecture]]></institution_en><team_members_id>17796, 23650, 12978, 23756, 23752, 12861, 24013, 864831, 864830, 913, 25819, </team_members_id><team_members_names><![CDATA[Tihomir Tomić, Mladen Šercer, Boris Ćosić, Petar  Gvero, Saša Papuga, Davor Ljubas, Robert Mikulandric, Maja Fabulić Ruszkowski, Iva Sanja Beer Romac, Zlata Hrnjak-Murgić, Irma  Kremer, ]]></team_members_names><keywords_hr><![CDATA[plastični otpad, iskorištavanje energije, gorivo iz otpada, piroliza, isplinjavanje, utjelovljena primarna energija]]></keywords_hr><keywords_en><![CDATA[plastic waste, energy recovery, waste-to-fuel, pyrolysis, gasification, embedded primary energy]]></keywords_en><summary_hr><![CDATA[Zbrinjavanje plastičnog otpada postaje sve veći problem u svijetu pa tako i u Hrvatskoj, pri čemu veliki dio tog materijala završi na odlagalištima ili se akumulira u prirodnom okolišu. Iako su prednosti materijske oporabe (recikliranja) veće, ne mogu se sve količine plastičnog otpada zbrinuti na taj način zbog različitih tehničkih, ekonomskih ili ekoloških razloga.U ovom se projektu, između ostalih, razmatraju i inovativne tehnologije za valorizaciju otpadne plastike kao alternativnog izvora energije i goriva, poput postupaka pirolize, isplinjavanja ili katalitičkih procesa depolimerizacije. Svi relevantni postupci sagledavaju se s tehničkih, okolišnih i socio-ekonomskih aspekata. Istraživanje se provodi kombinacijom različitih modelskih alata u svrhu simulacije različitih lanaca plastičnog otpada od njegovog nastanka do konverzije u energiju, goriva i druge produkte kao i njihove optimizacije u cilju lakše integracije u postojeće sustave gospodarenja otpadom i sustave proizvodnje energije. Pri tome se koristi višekriterijski pristup, od analize materijskih tokova, analize utjelovljene primarne energije i indeksa kumulativne potrošnje energije, do procjene cjeloživotnog vijeka.U okviru projekta provodi se mapiranje dostupnih količina i vrsta otpadne nereciklabilne plastike na prostoru RH. Formirat će se i klaster zainteresiranih tvrtki iz industrije koje mogu imati koristi od provedenih istraživanja. Unutar klastera definirat će se potencijalni pilot-projekti zasnovani na nekoj od naprednih tehnologija energetske konverzije. Za razmatrane procese kod odabranih studija slučaja provest će se numeričko modeliranje, s eksperimentalnom validacijom. Vezano uz to biti će napravljene laboratorijske analize uzoraka ulaznog otpada kao i izlaznog produkta, a za same procese biti će urađena energetska, eksergo-ekonomska i detaljna LCA analiza procesa. Naposljetku će se napraviti tehno-ekonomska analiza s procjenom isplativosti predloženih rješenja za odabrane realne slučajeve.]]></summary_hr><summary_en><![CDATA[Disposal of plastic waste is becoming increasingly problematic in the world as well as in Croatia, where a large part of this material ends up in landfills or accumulates in a natural environment. Although the benefits of material recovery (recycling) are higher, not all the quantities of plastic waste can be disposed on that way because of different technical, economic or ecological reasons.In this project, among others, innovative technologies for the valorisation of waste plastics as alternative energy and fuel, such as pyrolysis, gasification or catalytic depolymerization processes, are also considered. All relevant methods are reviewed from the technical, environmental and socio-economic aspects. The research is carried out by a combination of different model tools for the simulation of various plastic waste chains from its emergence to conversion into energy, fuels and other products as well as their optimization in order to facilitate integration into existing waste management and energy production systems. This involves a multi-criteria approach, from material flow analysis, embedded primary energy analysis, and cumulative energy consumption index to life cycle analysis.Within the project, the mapping of the available quantities and types of unrecyclable waste plastic in the Republic of Croatia is being carried out. A cluster of interested companies from industry that could benefit from the research will be formed. Within the cluster, potential pilot projects will be defined based on one of the advanced energy conversion technologies. Numerical modeling, with experimental validation, will be performed for the selected processes in the case studies. Furthermore, laboratory analyses of samples of input plastic waste and output products-fuel, and for the processes will be carried out the energetic, exergo-economic, and detailed LCA analysis. Finally, a techno-economic analysis will be carried out with the estimation of the feasibility for selected real cases.]]></summary_en></project><project>
<id>7346</id><title_hr><![CDATA[Derivati harmina kao potencijalni antimalarici]]></title_hr><title_en><![CDATA[]]></title_en><user_id>6183</user_id><user_firstLast_name>Zrinka Rajić Džolić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-01</proposal_call><code>DOK-2018-01-4042</code><acronim><![CDATA[CLICKforMALARIA]]></acronim><duration>01.09.2018 - 31.12.2022</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, </scie_field_hr><scie_field_en>Chemistry, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Farmaceutsko-biokemijski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Pharmacy and Biochemistry]]></institution_en><team_members_id>25221</team_members_id><team_members_names><![CDATA[ Doktorand: Marina Marinović ]]></team_members_names><keywords_hr><![CDATA[malarija, harmin, sinteza, antimalarijsko djelovanje, citotoksičnost, studije metabolizma]]></keywords_hr><keywords_en><![CDATA[malaria, harmine, synthesis, antimalarial activity, citotoxicity, metabolic studies]]></keywords_en><summary_hr><![CDATA[Malarija je smrtonosna bolest tropskih i subtropskih krajeva koja se prenosi ubodom komarca, a uzrokovana je parazitima roda Plasmodium. Cjepivo protiv malarije ne postoji, kao ni učinkovito uništavanje prijenosnika malarije. Osim toga, pojava otpornosti vrsta Plasmodium na postojeće lijekove dovodi do neučinkovitosti sadašnje terapije i zahtijeva otkriće lijekova s novim mehanizmima djelovanja. Alkaloidi b-karbolinskog tipa prisutni su u biljkama Peganum harmala i Eurycoma longifolia, koje se više od 2 tisućljeća koriste u tradicionalnoj kineskoj medicini za liječenje malarije i karcinoma. Djelatne supstancije ekstrakta biljke su alkaloidi harmin, harmalin, harmalol i harman. In vitro i in vivo studije pokazale su da harmin posjeduje snažno antimalarijsko djelovanje. Njegov mogući mehanizam djelovanja je inhibicija proteina toplinskog šoka 90 iz P. falciparum, koji je nužan za normalni razvoj parazita i ima važnu ulogu u razvoju rezistencije na postojeće antimalarike. U ovom projektu predviđeno je dizajniranje i sinteza knjižnice spojeva, koji se sastoje od harmina i 1) derivata cimetne kiseline (harmicini), 2) poznatih antimalarika: klorokina i meflokina (harmikini) i 3) ferocena (harmoceni). U sva tri tipa predviđenih spojeva poveznica će biti 1H-1,2,3-triazol, koji se pokazao korisnim u pripravi različitih biološki aktivnih spojeva. Predviđeni spojevi pripravit će se uobičajenim metodama sintetske organske kemije, te korištenjem modernih pristupa, &#39;&#39;click&#39;&#39; kemije i sinteze uz pomoć mikrovalova.Sintetiziranim spojevima ispitat će se antimalarijsko djelovanje in vitro, na eritrocitnu i hepatocitnu fazu plazmodija, te citoksično djelovanje na humane stanične linije. Uz to, provest će se studije metabolizma biološki aktivnih spojeva.Konačni rezultat projekta biti će novi spojevi učinkoviti protiv rezistentnih sojeva roda Plasmodium. Najaktivniji spojevi biti će polazišna točka za budući razvoj inovativnih lijekova.]]></summary_hr><summary_en><![CDATA[Malaria is a deadly mosquito-borne tropical and subtropical disease, caused the parazite of the genus Plasmodium. There is neither available vaccine, nor reliable vector control. In addition, Plasmodium is developing resistance to the existing therapy, which urges the discovery of novel drugs with new mechanisms of action.Alkaloids of b-carboline type are present in the medicinal plants Peganum harmala and Eurycoma longifolia, which have been used in the traditional Oriental medicine for the treatment of cancer and malaria. The active ingredients were identified as harmine, harmaline, harmalol and harman. In vitro and in vivo studies have proven harmine&#39;s antimalarial activity. Its possible mechanism of action is selective inhibition of P. falciparum heat shock protein 90, which is crucial for the parazite development and may play a major role in drug resistance. In the proposed project we decided to focus on the design and synthesis of a compound library, comprising harmine and 1) cinnamic acid moiety (harmicines), 2) known antimalarial drugs: chloroquine or mefloquine (harmiquines) and 3) ferrocene scaffold (harmocenes). The final compounds will incorporate 1H-1,2,3-triazole scaffolds, which proved to be useful in the synthesis of various biologically active compounds. Standard methods of synthetic organic chemistry, as well as modern approaches, such as click chemistry and microwave assisted synthesis will be employed. Antimalarial activity of the prepared compounds will be evaluated in vitro on both erythrocytic and hepatic stage of the Plasmodium, as well as cytotoxycity against human cell lines. In addition, metabolism studies for the biologically active compounds will be performed. As a final result, we will provide new candidate therapeutics against drug-resistant malaria parasite. The most active compounds will offer a valuable starting point for future development of innovative medicines.]]></summary_en></project><project>
<id>7352</id><title_hr><![CDATA[Modeliranje mentalne gramatike hrvatskoga: ograničenja informacijske strukture]]></title_hr><title_en><![CDATA[]]></title_en><user_id>12893</user_id><user_firstLast_name>Anita Peti-Stantić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-01</proposal_call><code>DOK-2018-01-5567</code><acronim><![CDATA[MEGAHR/MEGACRO]]></acronim><duration>01.10.2018 - 30.09.2022</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Filologija, </scie_field_hr><scie_field_en>Philology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Filozofski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Humanities and Social Sciences]]></institution_en><team_members_id>25299</team_members_id><team_members_names><![CDATA[ Doktorand: Vedrana Gnjidić ]]></team_members_names><keywords_hr><![CDATA[mentalna gramatika, informacijska struktura, računalno modeliranje, psiholingvistika, paralelna arhitektura, jezična kompetencija]]></keywords_hr><keywords_en><![CDATA[mental grammar, information structure, computational modeling, psycholinguistics, parallel architecture, language competence]]></keywords_en><summary_hr><![CDATA[Osnovni je cilj projekta Modeliranje mentalne gramatike hrvatskoga: ograničenja informacijske strukture odrediti gradivne sastavnice informacijske strukture mentalne gramatike hrvatskoga. Na temelju korpusnog i psiholingvističkog pristupa istražit ćemo načine procesiranja morfosintaktičkoga i semantičkoga slaganja konkretnih i/ili apstraktnih leksičkih jedinica u koordiniranim i eliptičnim strukturama, kao i načine procesiranja informacijske strukture rečenice s obzirom na smještaj klitika. Na temelju toga ćemo odrediti skup nužnih, univerzalnih kao i jezičnospecifičnih obrazaca koji određuju informacijsku strukturu hrvatskoga, na morfosintaktničkoj i na semantičkoj razini. Usredotočit ćemo se na lokalna (linearna) i globalna (hijerarhijska) ograničenja procesiranja u mentalnoj gramatici hrvatskoga. Teorijske posljedice takvoga pristupa vidjet će se u mogućnosti razvijanja modela jezičnoga procesiranja, kao i za određivanje i uspostavljanje veza između globalnih i lokalnih gradivnih elemenata mentalne gramatike hrvatskoga. Na praktičnoj će razini projekt kroz kurikularnu obnovu pridonijeti poboljšanju produktivne jezične kompetencije u okvirima obrazovnog sustava. Kako bismo ostvarili ove ciljeve, provest ćemo tri vrste aktivnosti: 1) na temelju korpusa hrWaC uspostavit ćemo korelaciju između kategorija konkretnosti i predočivosti za 3000 leksičkih jedinica kao i za skup gramatičkih jedinica (zamjeničkih i glagolskih klitika); 2) uspostavit ćemo odnos između konretnosti i slaganja (s obzirom na rod, elipsu i smještaj klitika); 3) odredit ćemo specifične obrascie potrebne za izgradnju komunikacijski učinkovitih mreža riječi i gramatičkih struktura u hrvatskom obrazovnom sustavu.Metodološka inovativnost istraživanja ogleda se u povezivanju teorijski informiranog kvalitativnog i kvantitativnog psiholingvistički relevantnog istraživanja koje će omogućiti uspostavu prediktivne leksičke analize na razini korpusa, kao i na razini gramatičkih obrazaca mentalne gramatike.]]></summary_hr><summary_en><![CDATA[The goal of the project The Building Blocks of Croatian Mental Grammar: Constraints of Information Structure is to determine the building blocks of the information structure of Croatian mental grammar. Specifically, based on corpus and psycholinguistic research, we will look into how speakers process morphosyntactic and semantic agreement of concrete and/or abstract lexical items in coordinated constructions and elliptical conditions, as well as how they process sentence information structure with regard to complex clitic cluster positioning. Thus, we will determine a set of necessary, universal and language-specific patterns that represent the requirements determining the information structure in Croatian, both on the morphosyntactic and the semantic level. We are predominantly interested in local (linear) and global (hierarchical) processing constraints within the mental grammar of Croatian. Our approach will have theoretical consequences for developing a model of language processing, as well as identifying and correlating global and local building blocks of mental grammar of Croatian. On the practical level, we seek to improve the productive linguistic competence of pupils in the education system. This will be operationalized through three main activities: (1) psycholinguistically establishing a correlation between concreteness and imageability for a set of high and low frequency lexical and grammatical items (clitics) based on corpus data; (2) psycholinguistically establishing the relationship between concreteness and agreement (in gender, ellipsis and clitic cluster positioning); (3) establishing language-specific patterns for building effective word and grammar webs within the educational system. Methodological novelty is reflected in connecting a theoretically-based qualitative and quantitative psycholinguistic research with a corpus study, which will enable the establishment of a predictive lexical analysis, as well as grammatical patterns in mental grammar.]]></summary_en></project><project>
<id>7359</id><title_hr><![CDATA[Nanokompoziti s perovskitima za fotovoltaike, fotokatalizu i senzoriku]]></title_hr><title_en><![CDATA[Nanocomposites comprising perovskites for photovoltaics, photo-catalysis and sensing]]></title_en><user_id>3922</user_id><user_firstLast_name>Andreja Gajović</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2018-01</proposal_call><code>IP-2018-01-5246</code><acronim><![CDATA[NanoPeroPhotoSens]]></acronim><duration>01.11.2018 - 31.10.2022</duration><status>Završio</status><financ_value>196.500,76 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, Kemija, </scie_field_hr><scie_field_en>Physics, Chemistry, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>12522, 3932, 12524, 3012, 1271, 12832, 1338, 2580, 13228, 22501, 23623, 1529, 22804, 742, 2527, 18922, 28192, 861726, 864912, 26021, 865293, </team_members_id><team_members_names><![CDATA[Krunoslav Juraić, Milivoj Plodinec, Daniel Meljanac, Davor Gracin, Nikša Krstulović, Jelena Macan, Vilko Mandić, Igor Lukačević, Maja Varga Pajtler, Matko Mužević, Denis Stanić, Ivana Grčić, Marko Petric, Igor Petrović, Ivana Melnjak, Lucija Radetić, Tihana Čižmar, Vedran Kojić, Andreja Žužić, Mario Bohač, Ivan Kovač, ]]></team_members_names><keywords_hr><![CDATA[perovskitni oksidi, BaTiO3, oksidni perovskiti na bazi Mn, nanostructure, nanokompoziti, fotovoltaici, fotokataliza, senzorika]]></keywords_hr><keywords_en><![CDATA[perovskite oxides, BaTiO3, Mn-based oxide perovskites, nanostrucures, nanocomposites, photovoltaics, photo-catalysis, sensing]]></keywords_en><summary_hr><![CDATA[Projekt će biti nastavak istraživanja provedenih u prethodnom razdoblju, posvećenih mogućnosti podešavanja svojstava tankih filmova za uporabu u fotoosjetljivim uređajima, modificiranjem njihove strukture i sastava. Istraživati će se nano-strukture i nanokompoziti koji imaju poseban oblik, kao što su nanocjevčice, nano-štapići i vrlo tanki slojevi. Za dodatnu prilagodbu svojstava, modificirat će se kemijski sastav i struktura površine filmova elektrokemijskim jetkanjem, prekrivanjem nanočesticama i tretmanom u reaktivnim plinovima. Podrška eksperimentalnom radu u postizanju ciljanih svojstava za fotonaponsku, senzorsku i fotokatalitičku primjenu, bit će teorijska predviđanja temeljena na DFT računu elektronske strukture pojedinih materijala i nanokompozita. Eksperimenti na ZnO i TiO2, provedeni u prethodnom projektu, bit će prošireni na oksidne materijale koji imaju perovskitnu strukturu, počevši od BaTiO2 i perovskita na bazi Mn. U daljnjim koracima, funkcionalnost istraživanih tankih filmova će biti istražena njihovom integracijom u dvoslojne i višeslojne strukture relevantne za pojedinu vrstu fotoosjetljivih uređaja.Za pripravu i modifikaciju tankih filmova će se koristiti razne fizikalne i kemijske metode. Strukturna i funkcionalna svojstva će se određivati standardnim tehnikama i korelirati s parametrima formiranja, što će omogućiti bolji uvid u procese relevantne za rast tankog filma. Dobiveni eksperimentalni podaci, u kombinaciji s teorijskim predviđanjima temeljenim na DFT izračunima, rezultirati će boljim razumijevanjem utjecaja sastava i nanostrukture na makroskopska svojstva. Ovo će omogućiti procjenu u kojoj mjeri je moguće, postupcima korištenim u projektu, poboljšati svojstava fotovoltaika, fotokatalizatora i senzora. Dobiveni rezultati će biti objavljeni u časopisima s visokim faktorom odjeka iz područja znanosti o materijalima.Projekt će biti djelomično posvećen obrazovanju diplomskih i doktorskih studenata što podrazumijeva i razvoj novih karijera.]]></summary_hr><summary_en><![CDATA[Project will be continuation of research conducted in the previous period, devoted to exploring possibility of tailoring thin film properties by structural and compositional modification, for use in photosensitive devices. The nano-sized structures and nanocomposites with specific shape as nanotubes, nanorods and thin layers will be investigated. For additional adjustment of properties, the surface chemistry and structure will be modified by electrochemical etching, decoration with nanoparticles and treatment in reactive gases. The achievement of preferred properties targeting for the photovoltaic, sensing and photo-catalytic application will be supported by prediction of theoretical study, based on DFT calculation of electronic structure of individual materials and nanocomposites. The experiments on ZnO and TiO2, done in previous project, will be extended on oxide materials having perovskite structures, starting with BaTiO2 and Mn based perovskites. In further steps, the functionality of studied thin films will be tested by integration in bi-layer and multilayer structures as a part of photosensitive device.For preparation and modification of thin films, various physical and chemical methods will be used. Their structural and functional properties will be determined by using standard techniques and correlated with parameters of formation, enabling better insight into the processes relevant for the thin film growth. The obtained experimental data, combined with theoretical predictions based on DFT calculations, will lead to better understanding of the influence of composition and nanostructure on macroscopic properties. It will enable the evaluation of possibilities of using applied approaches for improving properties of photovoltaics, photo-catalysts and sensors. The results will be published in the high ranking journals in the field of material science.Project will be partially devoted to education of the graduate and PhD students implying new careers development.]]></summary_en></project><project>
<id>7360</id><title_hr><![CDATA[Nove geometrije za gravitaciju i prostor-vrijeme]]></title_hr><title_en><![CDATA[New Geometries for Gravity and Spacetime]]></title_en><user_id>5035</user_id><user_firstLast_name>Athanasios Chatzistavrakidis</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2018-01</proposal_call><code>IP-2018-01-7615</code><acronim><![CDATA[GRASP]]></acronim><duration>01.10.2018 - 28.02.2023</duration><status>Završio</status><financ_value>111.354,44 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, </scie_field_hr><scie_field_en>Physics, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>52, 1356, 23690, 23722, 25315, 25067, 29368, 865431, 865552, </team_members_id><team_members_names><![CDATA[Larisa Jonke, Zoran Škoda, Richard Szabo, Bergshoeff Eric, Georgios Karagiannis, Grgur Šimunić, Kökényesi Zoltan, Pantelis Panopoulos, Jan Rosseel, ]]></team_members_names><keywords_hr><![CDATA[Teorija struna, dualnosti u teoriji struna, ne-geometrijske jakosti polja, sigma modeli, Newton-Cartanova gravitacija]]></keywords_hr><keywords_en><![CDATA[String theory, string dualities, non-geometric fluxes, generalized geometry, sigma models, Newton-Cartan gravity]]></keywords_en><summary_hr><![CDATA[Kako pomiriti opću teoriju relativnosti i kvantnu mehaniku te opisati kvantnu strukturu prostor-vremena je jedan od glavnih izazova za teorijsku fiziku danas. Dva istaknuta okvira unutar kojih se taj problem rješava su teorija struna i nekomutativna geometrija. Nedavno ostvareni napredak u području ukazuje da zatvorene strune &#39;&#39;vide&#39;&#39; nekomutativnu i moguće neasocijativnu geometriju prostor-vremena. U okviru ovog projekta želimo produbiti naše razumijevanje same geometrije i gravitacijskog sektora teorije struna. Preciznije, istraživat ćemo propagaciju struna na pozadini koja uključuje ne-geometrijske jakosti polja koristeći matematičke metode nekomutativne i neasocijativne geometrije, Courantovih algebroida te generalizirane i više geometrije. Glavni cilj istraživanje je osigurati solidnu geometrijsku osnovu za teorije koje su invarijantne s obzirom na T- i U- dualnost, poput dvostruke teorije polje i izuzetne teorije polje, konstruirati gravitacijske modele koje uključuju poopćene jakosti polja te brane kao izvore i zatim istražiti fizikalne implikacije tih modela. Drugi cilj je usmjeran na istraživanje geometrijske strukture nerelativističkih teorija gravitacije koje u zadnje vrijeme privlače puno pažnje zbog primjena u raznim područjima fizike, od holografije, teorije kondenzirane tvari do teorije struna. Rezultati projekta će imati bitan utjecaj na naše razumijevanje gravitacijskih interakcija te će u višegodišnjoj perspektivi doprinjeti rasvjetljavnju pitanja začetka i strukture svemira.]]></summary_hr><summary_en><![CDATA[Reconciling general relativity and quantum mechanics and understanding the quantum structure of spacetime is one of the major challenges for present day theoretical physics. Two prominent frameworks addressing this conundrum are string theory and noncommutative geometry. Recent advances provide evidence that the generic spacetime geometries experienced by closed strings are noncommutative and even nonassociative. Within this project we aim at a deeper understanding of the geometry and the gravitational sector of string theory. In particular, we are going to study strings propagating in backgrounds with non-geometric fluxes, using mathematical tools such as noncommutative and nonassociative differential geometry, Courant algebroids, generalized and higher geometry. Our main goal is to provide a solid geometric basis for T- and U-duality-invariant theories, such as double field theory and exceptional field theories, elucidate the structure of string and membrane sigma models, construct models of gravity in the presence of general fluxes and brane sources and study their physical implications. A second goal is to investigate the geometric structure of non-relativistic gravity theories, which attract a lot of interest in recent years due to applications in diverse physical settings, ranging from holography and condensed matter physics to string theory. We expect that the results of this project will have an impact in our understanding of the gravitational interaction, and will contribute to the long-term goal of elucidating the origin and the structure of the universe. ]]></summary_en></project><project>
<id>7367</id><title_hr><![CDATA[Određivanje ključnih molekula epitelno-mezenhimalne tranzicije kao mogućih ciljeva za terapiju raka jajnika ]]></title_hr><title_en><![CDATA[]]></title_en><user_id>3713</user_id><user_firstLast_name>Anamaria Brozović</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-01</proposal_call><code>DOK-2018-01-8086</code><acronim><![CDATA[DEvOuT]]></acronim><duration>17.10.2018 - 29.01.2024</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Biologija, </scie_field_hr><scie_field_en>Biology, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>25301</team_members_id><team_members_names><![CDATA[ Doktorand: Margareta Pernar ]]></team_members_names><keywords_hr><![CDATA[Epitelno-mezenhimalna tranzicija, otpornost na lijekove, rak jajnika, miRNA-200, karboplatina]]></keywords_hr><keywords_en><![CDATA[epithelial-mesenchymal transition, drug resistance, ovarian cancer, miRNA-200, carboplatin]]></keywords_en><summary_hr><![CDATA[U najvećem broju slučajeva rak jajnika dijagnosticira se u uznapredovalom stadiju zbog čega je kemoterapija neuspješna. Kod bolesnica koje odgovore uspješno na terapiju čak u 70-80% bolest se ponovo javlja unutar godine dana. Prema tome, razvoj otpornosti na terapiju glavna je prepreka njene uspješnosti. Karboplatina (CBP) je jedan od lijekova prve linije terapije. Proces epitelno-mezenhimalna tranzicija (EMT) korelira s napredovanjem bolesti i metastaziranjem te otpornosti na terapiju. Literaturni podaci opisuju promjene različitih proteina i miRNA u tim procesima. Međutim, još uvijek nije poznato koje od tih molekula su uključene u oba procesa. U okviru naših preliminarnih istraživanja razvili smo nekoliko staničnih linija raka jajnika otpornih na CBP koje su prošle proces EMT, te u jednoj od njih identificirali smanjenu ekspresiju svih članova miRNA-200 obitelji za koje se iz literature zna da reguliraju ekspresiju mnogih proteina u stanici. Budući da se proces EMT i razvoj otpornosti događaju istovremeno naša je hipoteza da postoje ključne molekule koje se uključene u oba procesa te da bi se one mogle koristiti kao ciljne molekule za terapiju. Prvi cilj ovog projekta je u in vitro modelima kulture stanica pronaći ključne molekule (proteine na transkripcijskom i translacijskom nivou i miRNA) odgovorne za EMT i razvoj otpornosti na CBP i njihovu međusobnu povezanost. Uključenost svake od pronađenih molekula utvrdit će se odgovarajućim funkcionalnim testovima. Drugi cilj je utvrditi ekspresijski status pronađenih molekula u uzorcima tkiva bolesnica (normalno vs tumorsko) te korelirati pronađene promjene s odgovorom bolesnica na terapiju. Treći cilj je potvrditi važnost otkrivenih molekula u regulaciji EMT i razvoju otpornosti na CBP u modelu organoida. Ukupni cilj projekta je pronaći ključne molekule odgovorne za EMT i otpornost na CBP, te moguće korištenje tih molekula u  liječenju bolesnica oboljelih od raka jajnika.]]></summary_hr><summary_en><![CDATA[Most epithelial ovarian cancer patients are diagnosed with advanced-stage disease and do not respond to chemotherapy. About 70-80% of patients, who respond to the chemotherapy, experience a recurrence of cancer within months to years. Therefore the development of tumor drug resistance is the major problem for a successful therapy. Carboplatin (CBP) is one of the drugs in the first-line therapy. Epithelial-mesenchymal transition (EMT) correlates with cancer progression, metastasis and drug resistance. Literature data have shown changes in expression of different proteins and miRNA in these processes. However, it is still not known which molecules are involved in both of these processes. Our preliminary research resulted in establishment of several CBP resistant ovarian cancer cell lines that underwent EMT. In one of these cell lines we found decreased expression of miRNA-200 members, for which it has been known to regulate many different proteins in the cells. Since EMT and development of drug resistance have been shown to occur in the cell simultaneously, our hypothesis proposes the existence of key molecules involved in both of these processes making them valuable therapy targets. The first goal of this project is to determine key molecules (proteins at transcriptional and translation levels and miRNA) involved in EMT and development of drug resistance and to confirm their role by using functional tests. The second goal is to establish the expression pattern of these molecules in tissue samples from patients with ovarian cancer (normal vs tumor) and to correlate these changes with the patient response to the therapy. The third goal is to confirm the importance of identified molecules in EMT and drug resistance development by using organoids culture. The overall goal of this project is to find key molecules involved in EMT and development of drug resistance and to investigate the possibility of using them as targets for ovarian cancer therapy.]]></summary_en></project><project>
<id>7368</id><title_hr><![CDATA[BlueMed]]></title_hr><title_en><![CDATA[]]></title_en><user_id>667</user_id><user_firstLast_name>Melita Peharda Uljević</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-01</proposal_call><code>DOK-2018-01-9373</code><acronim><![CDATA[]]></acronim><duration>01.08.2018 - 31.10.2022</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Biologija, </scie_field_hr><scie_field_en>Biology, </scie_field_en><institution_hr><![CDATA[Institut za oceanografiju i ribarstvo]]></institution_hr><institution_en><![CDATA[Institute of Oceanography and Fisheries]]></institution_en><team_members_id>25078</team_members_id><team_members_names><![CDATA[ Doktorand: Hana Uvanović ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>7370</id><title_hr><![CDATA[Primjena inovativnih metoda u praćenju proteolitičkih, lipolitičkih i oksidativnih procesa tijekom proizvodnje pršuta]]></title_hr><title_en><![CDATA[]]></title_en><user_id>19625</user_id><user_firstLast_name>Helga Medić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-01</proposal_call><code>DOK-2018-01-3240</code><acronim><![CDATA[IM-HQHAM ]]></acronim><duration>10.09.2018 - 09.09.2022</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Prehrambena tehnologija, </scie_field_hr><scie_field_en>Food technology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prehrambeno-biotehnološki fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Food Technology and Biotechnology]]></institution_en><team_members_id>25241</team_members_id><team_members_names><![CDATA[ Doktorand: Ivna Poljanec ]]></team_members_names><keywords_hr><![CDATA[pršut, proteoliza, oksidacija proteina, masena spektrometrija, lipoliza, aroma, senzorska analiza]]></keywords_hr><keywords_en><![CDATA[dry-cured ham, proteolysis, protein oxidation, mass spectrometry, aroma, sensory analysis]]></keywords_en><summary_hr><![CDATA[Primjena novih metoda masene spektrometrije u prehrambenoj tehnologiji omogućuje bolji uvid u biokemijske procese koji se odvijaju tijekom prerade hrane, a njihovi produkti utječu na kvalitetu i nutritivnu vrijednost prehrambenih proizvoda.  S obzirom da su proteini i masti osnovne komponente pršuta, imaju značajan utjecaj na nutritivnu vrijednost, a njihovom razgradnjom tijekom proizvodnog procesa nastaju spojevi odgovorni za teksturu, boju i aromu proizvoda. Znanstveno je utvrđeno da su glavne biokemijske reakcije koje se odvijaju tijekom proizvodnje pršuta proteoliza i lipoliza te su najnovija znanstvena istraživanja u svijetu intenzivno usmjerena na proteolizu i oksidaciju proteina zbog njihovog utjecaja na kvalitetu gotovog proizvoda. Brojni čimbenici koji proizlaze iz tehnološkog procesa proizvodnje utječu na intenzitet proteolitičkih, lipolitičkih i oksidativnih procesa. Stoga je cilj ovog projekta istražiti utjecaj brzine i opsega proteolitičkih, lipolitičkih i oksidativnih procesa na teksturu, boju i aromu finalnog proizvoda, prateći promjene na proteinima i lipidima kroz cijeli proizvodni proces, korištenjem inovativnih analitičkih metoda. Odredit će se  i identificirati proteini, peptidi i amino kiseline kao i proteolitički indeks te oksidacija proteina određivanjem ukupnih proteinskih karbonila. Paralelno s navedenim, odredit će se i oksidacija masti te sastav masnih kiselina, boja, osnovni kemijski sastav, koncentracija NaCl, proteinski i neproteinski dušik te tekstura pršuta. Rezultati ovog projekta pokazat će kako se primjenom novih metoda masene spektrometrije može utvrditi odnos između uvjeta prerade, biokemijskih procesa i teksture pršuta kako bi se osigurala visoka kvaliteta proizvoda. ]]></summary_hr><summary_en><![CDATA[The application of novel mass spectrometry-based methods in food technology provides better insight into the biochemical processes that occur during the processing and their products affect the quality and nutritional value of food. Proteins and fats are major components of dry-cured ham with significant impact on the nutritional value of the product. Through their degradation during the processing arise compounds responsible for the product texture, color and flavor. It has been scientifically established that the main biochemical reactions during the production of dry-cured ham are proteolysis and lipolysis and current scientific research studies are focused intensely on proteolysis and oxidation of proteins because of their impact on the quality of the final product. Numerous factors arising from the technological process influence the intensity of proteolytic, lipolytic and oxidative processes. Therefore, the aim of this project is to investigate the influence of proteolytic, lipolytic and oxidative changes on the texture, color and flavor of the final product by monitoring changes of the proteins and lipids throughout the dry-cured ham process using innovative analytical methods. Proteins will be identified, peptides and amino acids, proteolysis index, the oxidation of proteins and protein carbonyls will be analyzed. In parallel, the oxidation of fat and fatty acid composition, color, basic chemical composition, concentration of NaCl, protein and non-protein nitrogen and texture of the ham will be determined. The results of this project will show that the application of novel mass spectrometry-based methods can help in defining the relationship among processing conditions, the biochemical processes and the texture of dry-cured ham to ensure high quality product.]]></summary_en></project><project>
<id>7371</id><title_hr><![CDATA[Klimatske promjene i invazivne vrste – utvrđivanje utjecaja na bioraznoliost nativnih slatkovodnih rakova i pastrva i njihova konzervacija]]></title_hr><title_en><![CDATA[]]></title_en><user_id>12634</user_id><user_firstLast_name>Ivana Maguire</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-01</proposal_call><code>DOK-2018-01-9589</code><acronim><![CDATA[CLINEinBIOta]]></acronim><duration>10.10.2018 - 09.10.2022</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Biologija, </scie_field_hr><scie_field_en>Biology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>25329</team_members_id><team_members_names><![CDATA[ Doktorand: Leona Lovrenčić ]]></team_members_names><keywords_hr><![CDATA[genetska varijabilnost, evolucijska povijest, Astacus astacus, Austropotamobius torrentium, Salmo trutta, modeli pogodnosti staništa]]></keywords_hr><keywords_en><![CDATA[genetic variability, evolutionary history, Astacus astacus, Austropotamobius torrentium, Salmo trutta, habitat suitability models]]></keywords_en><summary_hr><![CDATA[Slatkovodni su ekosustavi pod sve većim antropogenim pritiskom što negativno utječe na njihovu bioraznolikost, a time i na njihovo funkcioniranje te usluge koje pružaju. Bioraznolikost posebice ugrožavaju globalne klimatske promjene i unos stranih vrsta. Stoga je cilj ovog projekta istražiti njihov utjecaj na slatkovodne organizme. U fokusu predloženog projekta su tri slatkovodne zavičajne vrste (potočni i plemeniti rak, potočna pastrva) koje imaju ključnu ulogu u ekosustavima, osiguravaju njihovo normalno funkcioniranje (rakovi) i ekonomski su značajne (pastrve). Njihov nestanak iz staništa značajno mijenja slatkovodne ekosustave, dovodi do promjena u dinamici transporta sedimenta te uzrokuje promjene u sastavu zajednica. Ove su vrste osjetljivi na promjene u staništu, a zbog negativnog antropogenog utjecaja i sve izraženijih klimatskih promjena, ugrožene su i zaštićene međunarodnim i nacionalnim zakonima.Cilj predloženog projekta je istražiti genetsku varijabilnost odabranih populacija ove tri vrste upotrebom mitohondrijskih, nuklearnih i mikrosatelitnih DNA biljega i doprinijeti novim spoznajama o njihovoj evolucijskoj povijesti i nasljeđu te identificirati njihove evolucijski bitne jedinice i jedinice upravljanja. Isto tako cilj je razviti modele potencijalno pogodnih područja za invazivne vrste rakova i strane linije pastrva kako bismo mogli predvidjeti područja i zavičajne populacije koja će biti pod njihovim najvećim pritiskom u budućnosti. Nadalje, cilj je izraditi modele pogodnosti staništa za proučavane zavičajne vrste, te njihova projekcija u budućnost prema različitim scenarijima klimatskih promjena što će omogućit identifikaciju područja koja će biti izrazito nepogodna za njihovo preživljavanje, kao i područja koja će osigurati njihov dugotrajni opstanak. Očekujemo da će dobiveni rezultati poslužiti kao kvalitetna osnova za izradu adekvatnih konzervacijskih strategija i planova upravljanja s ove tri osjetljive i ključne vrste slatkovodnih ekosustava. ]]></summary_hr><summary_en><![CDATA[Freshwater ecosystems are under growing anthropogenic pressure that negatively influence onto their biodiversity, and consequently onto alteration of ecosystem processes and impairment of ecosystem services. Nowadays, climate change and introduction of non-native species are recognised as one of the main factors of freshwater biodiversity loss. Therefore, objective of this project is to study their influence onto freshwater organisms. In the focus of the proposed project are three freshwater native species (stone and noble crayfish, brown trout) that have key role in the ecosystems; crayfish ensuring their normal functioning and trout being economically important.  Their disappearance from a habitat significantly alters freshwater ecosystem processes, species abundance and diversity. These three species are highly sensitive to habitat alteration, and due to negative human impacts onto their habitats and pronounced climate changes, they are vulnerable and protected by international and national legislation. The purpose of proposed project is to study genetic variability of different populations of these three species using mitochondrial, nuclear and microsatellite DNA markers, aiming to bring new insight into their evolutionary history and to identify their evolutionary significant and management units. Further, the aim is to develop habitat suitability models for non-native invasive crayfish species and allochthones trout lineages that would enable us to foresee areas that will be under biggest pressure in the future. Also, the aim is to develop habitat suitability models for native species future distribution under climate change scenarios that will enable us to identify areas, which will be unsuitable for their survival as well as areas that will ensure their long-term survival. We expect that obtained results will serve as a sound base for development of conservation strategies and management plans for these three vulnerable freshwater species.]]></summary_en></project><project>
<id>7372</id><title_hr><![CDATA[Višestruki stresori u vodenom okolišu: razumijevanje svojstava stresora i receptora]]></title_hr><title_en><![CDATA[Understanding stressor and receptor properties in multi-stressed aquatic environments]]></title_en><user_id>12890</user_id><user_firstLast_name>Marko Rožman</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2018-01</proposal_call><code>IP-2018-01-2298</code><acronim><![CDATA[UNDERSTANDOR]]></acronim><duration>07.01.2019 - 06.01.2023</duration><status>Završio</status><financ_value>132.718,83 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Interdisciplinarne prirodne znanosti, Kemija, Biologija, </scie_field_hr><scie_field_en>Interdisciplinary natural sciences, Chemistry, Biology, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>1414, 3926, 19938, 23444, 20412, 23729, 1522, 29033, 27426, </team_members_id><team_members_names><![CDATA[Sandra Babić, Mirta Čizmić, Igor Novak, Ivančica Ternjej, Ana Previšić, Vicenç Acuna, Zrinka Karačić, Katarina Cetinić, Ivana Grgić, ]]></team_members_names><keywords_hr><![CDATA[stresori, vodeni okoliš, onečišćivač, spektrometrija masa, nanomaterijali, metabolomika, proteomika]]></keywords_hr><keywords_en><![CDATA[multiple stressors, aquatic environment, emerging contaminants, mass spectrometry, nanomaterials, metabolomics, proteomics]]></keywords_en><summary_hr><![CDATA[Posljednja znanstvena dostignuća prepoznaju sve veći utjecaj kombinacije različitih stresora na vodna tijela u Europi. Razumijevanje međudjelovanja stresora i njihovog utjecaja na biološki te kemijski status vodenih ekosustava jedan je od glavnih izazova u oblikovanju budućih politika za zaštitu okoliša. Kako bi odgovorili na navedeni izazov, utjecaje stresora treba sagledati jednako iz perspektive stresora i receptora. Sukladno tome, svrha ovog projekta je doprinijeti razumijevanju svojstava stresora i receptora. Iz „perspektive stresora“, primjenjujući metode računalne kemije kao i multifaktorska fotodegradacijska istraživanja, projekt će unaprijediti razumijevanje međuodnosa onečišćivača u smjesi stavljajući poseban naglasak na nanomaterijale i njihovu interakciju s drugim onečišćivačima tijekom procesa adsorpcije i fotodegradacije. Iz „perspektive receptora“ projekt je usmjeren na pružanje zbirnog pogleda na molekularne procese tijekom općeg odgovora na višestruki stres. UNDERSTANDOR predlaže korištenje Postrojenja umjetnih rijeka (jedinstvenog sustava u Europi) i mesokosmos pokusa koji će omogućiti vremensko &#39;&#39;omics&#39;&#39; profiliranje biofilma kao i vodenih beskralješnjaka tijekom izlaganja ekološki značajnim (dugoročna izloženost niskim dozama) stresnim događajima. Dobiveni profili omogućit će vremensku rekonstrukciju dinamike gena, proteina i metabolita u zajednici biofilma i vodenih beskralješnjaka u uvjetima višestrukog stresa (npr. onečišćivači, temperatura, suša). Okupljanjem interdisciplinarnog tima s četiri europske i jedne ne-europske znanstvene institucije s jedinstvenom kombinacijom znanja i vještina, stvoriti će se razina znanja i iskustva neophodna za provođenje projektnih aktivnosti. Očekujemo da će rezultati istraživanja u okviru ovog projekta imati znatan utjecaj na područje istraživanja slatkih voda.]]></summary_hr><summary_en><![CDATA[Current state-of-the-art research identifies Europe’s water bodies and resources influenced by a complex mixture of stressors. Understanding how stressors interfere and impact biological and chemical status of aquatic system is identified as main challenge for shaping future environmental policies. To meet the challenge multiple stressors effects should be understood equally from stressor and receptor side. Accordingly, UNDERSTANDOR aims at advancing our knowledge on stressor and receptor properties in multi-stressed aquatic environments. In particular, on “stressor’s side” the project will further develop and apply some of the cutting edge computational chemistry methods and multifactorial photodegradation studies to improve our understanding of ensemble interactions of emerging contaminants (ECs). Special emphasis will be put on carbon based nanomaterials and their interactions with other xenobiotics during adsorption and photodegradation. From a “receptor’s side” the project will provide a multidisciplinary perspective of molecular responses and mechanisms resulting from multiple stress events (e.g. ECs, temperature, drought). The project proposes use of Experimental Stream Facility (a unique European facility) and mesocosm experiments that will permit temporal “omics” profiling of biofilm community and aquatic macroinvertebrates at environmentally relevant (long-term low-dose) multiple stress events. Obtained profiles will enable reconstruction of time points in gene-protein-metabolite dynamics of biofilm and macroinvertebrates under stress conditions. By assembling a multidisciplinary team of four European and one non-European scientific institution with unique combination of skills and expertise, a critical mass of experience and knowledge will be mobilized to carry out the project activities. Accordingly, we expect that the results produced by this innovative research plan will have substantial impact on the field of inland water research.]]></summary_en></project><project>
<id>7374</id><title_hr><![CDATA[Karakterizacija kandidat gena za kongenitalne anomalije bubrega i urotrakta (CAKUT) tijekom razvoja u miša i čovjeka]]></title_hr><title_en><![CDATA[]]></title_en><user_id>12479</user_id><user_firstLast_name>Katarina Vukojević</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-01</proposal_call><code>DOK-2018-01-3987</code><acronim><![CDATA[CAKUT]]></acronim><duration>10.01.2019 - 09.10.2024</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Splitu, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Split School of Medicine]]></institution_en><team_members_id>25216</team_members_id><team_members_names><![CDATA[ Doktorand: Anita Muić ]]></team_members_names><keywords_hr><![CDATA[kongenitalne anomalije bubrega i urotrakta, genetika, imunohistokemija, imunofluorescencija, knock-out miš]]></keywords_hr><keywords_en><![CDATA[congenital anomalies of the kidney and urinary tract, genetics, immunohistochemistry, immunofluorescence, knock-out mice]]></keywords_en><summary_hr><![CDATA[Kongenitalne anomalije bubrega i mokraćnog sustava (CAKUT) u 40-50% pedijatrijskih bolesnika dovode do krajnjeg stadija zatajenja bubrega. Među kategorijama CAKUTa, kongenitalna opstruktivna uropatija predstavlja zajednički i teški oblik malformacija. Zbog nedostatka temeljnog uvida o njegovoj primarnoj patogenezi, dijagnostičke i terapijske mogućnosti su ograničene.Nedavno smo identificirali dominantne štetne mutacije u DSTYK genu koji kodira dvostruku serin-treonin i tirozin protein-kinazu, kod osoba s malformacijama mokraćnog sustava koristeći sekvenciranje exoma u kombinaciji s funkcionalnim modelom u zebraste ribice (New Engl J Med 2013). Protein kodiran DSTYK genom djeluje kao pozitivan regulator u signalizaciji faktora rasta fibroblasta (FGF), tijekom nefrogeneze. Osim toga, identificirali smo pet novih gena kandidata za CAKUT koji su pokazali ekspresiju u miša i čovjeka tijekom razvoja urinarnog trakta. Među tim genima, DLG1 i KIF12 su vjerojatno susceptibilni geni za razvoj CAKUTa kod ljudi (Kidney Int 2015).Ovdje predlažemo početnu karakterizaciju funkcije novih gena kandidata za CAKUT tijekom embrionalnog razvoja, nefrogeneze i razvoja uretera. Prvo ćemo istraživati profil vremenskog-prostornog izražaja i ko-lokaliziranje kandidat gena za CAKUT u različitim fazama embriogeneze u tkivima normalnih miševa i ljudskog zametka te bubrega i mokraćnog sustava u razvoju i usporediti markere nefrogeneze i razvoja uretera. Zatim ćemo odabrati jedan visoko prioritetni novi kandidat gen te generirati i okarakterizirati miša koji nosi mutaciju u ovom genu od interesa (knockout miš), zatim ćemo identificirati mehanizme kojima mutacije u ovom genu dovode do malformacija urinarnog trakta kod ljudi.Ova studija je osmišljena kako bi se okarakterizirali funkcionalni učinci kandidat gena za CAKUT u razvoju mokraćnih puteva, identificirati disregulacijske putove i na kraju osmisliti nove dijagnostičke alate i terapijske strategije za taj učestali oblik zatajenja bubrega.]]></summary_hr><summary_en><![CDATA[Congenital Anomalies of the Kidney and the Urinary Tract (CAKUT) account for 40-50% of pediatric end-stage kidney failure. Among CAKUT categories, congenital obstructive uropathy represents a common and severe form. Due to paucity of fundamental insight about its primary pathogenesis, diagnostic and therapeutic options are severely limited.  We recently identified dominant deleterious mutations in DSTYK, encoding a dual serine-threonine and tyrosine protein-kinase, in individuals with urinary tract malformations using exome sequencing combined to functional modeling in zebrafish (New Engl J Med 2013). The protein encoded by DSTYK acts as a positive regulator of fibroblast growth factor (FGF) signaling during nephrogenesis. Additionally, we identified five novel candidate genes for CAKUT that showed specific expression in the human and mouse developing urinary tract. Among these genes, DLG1 and KIF12 are likely novel susceptibility genes for CAKUT in humans (Kidney Int 2015).Here we propose to initially characterize the function of novel CAKUT candidate genes during embryonic development, nephrogenesis and ureteric development. We will first study the candidate genes temporal-spatial expression and colocalization profile during different stages of embryogenesis in normal mouse and human embryonic tissue and in developing kidneys and urinary tract and compare to markers of nephrogenesis and ureteric development. We will next choose one high-priority novel candidate gene and generate and characterize mouse harboring mutation in a gene of interest (knockout mice) to identify the mechanisms by which mutations in this gene lead to urinary tract malformations in humans. This study is designed to characterize the functional effect of CAKUT candidate genes in urinary tract development, to identify dysregulated pathways, and, ultimately, to devise novel diagnostic tool and therapeutic strategies for this common form of renal failure.]]></summary_en></project><project>
<id>7387</id><title_hr><![CDATA[Unitarne reprezentacije, automorfne i modularne forme]]></title_hr><title_en><![CDATA[Unitary representations, automorphic and modular forms]]></title_en><user_id>1079</user_id><user_firstLast_name>Marcela Hanzer</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2018-01</proposal_call><code>IP-2018-01-3628</code><acronim><![CDATA[UNAM]]></acronim><duration>09.10.2018 - 08.10.2022</duration><status>Završio</status><financ_value>120.047,78 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Matematika, </scie_field_hr><scie_field_en>Mathematics, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>23430, 23409, 863, 1000, 890, 850, 820, 1154, 17779, </team_members_id><team_members_names><![CDATA[Petar Bakić, Barbara Bošnjak, Darija Brajković, Igor Ciganović, Neven Grbac, Ivan Matić, Goran Muić, Marko Tadić, Sonja Žunar, ]]></team_members_names><keywords_hr><![CDATA[unitarne reprezentacije, automorfne forme, modularne forme, klasične grupe, metaplektička grupa]]></keywords_hr><keywords_en><![CDATA[unitary representations, automorphic forms, modular forms, classical groups, metaplectic group]]></keywords_en><summary_hr><![CDATA[U projektu Unitarne reprezentacije, automorfne i modularne forme uključujemo se u novi val istraživanja u okviru Langlandsovog programa, omogućen, prije svega, novim rezultatima Arthura i suradnika. Istražujemo dvije teme koje se međusobno isprepliću: unitarne reprezentacije reduktivnih (i srodnih) p-adskih grupa, te klasične modularne i automorfne forme. U istraživanju unitarnog duala klasičnih grupa, među ostalim i koristeći rezultate Moeglin o konstrukciji A-paketa, namjeravamo konstruirati široke familije reprezentacija analiziranjem parabolički induciranih reprezentacija specijalnog tipa i odrediti kompozicione nizove. Time ćemo generalizirati mnoge rezultate Speh, Tadića, Muića, Matića i Hanzer. Automorfne reprezentacije globalnih klasičnih grupa namjeravamo analizirati prije svega koristeći Eisensteinove redove, proučavane u radovima Hanzer i Muića, te nedavne Arthurove rezultate o endoskopiji. Iz tih rezultata namjeravamo dobiti rezultate o L-funkcijama, a u dobivanju informacija o slikama Eisensteinovih redova namjeravamo koristiti rezultate dobivene iz lokalne teorije. S druge strane, ti se rezultati mogu primijeniti i na proučavanje klasičnih modularnih formi, uz pažljivo konstruiranje restrikcija. Modularne forme namjeravamo i direktno istražiti koristeći Poincareove redove, istražujući uvjete neponištavanja generalizirajući Muićeve rezultate i nalazeći baze pojedinih prostora modularnih formi. U analiziranju reprezentacija metaplektičke grupe namjeravamo proučavati generičke reprezentacije, i to koristeći nedavne rezultate Savina, Takede, Lapida, Atobe i Gana o konstrukciji lokalnih faktora i o theta korespondenciji.]]></summary_hr><summary_en><![CDATA[In project Unitary representations, automorphic and modular forms we are joining a new wave of research in the framework of Langlands program which stems from the recent results of Arthur and collaborators. We explore two intertwining themes: unitary representations of reductive p-adic (and related) groups and classical modular and automorphic forms. In the research of the unitary dual of classical groups, using, among other things, Moeglin’s results about construction of A-packets, we intend to construct large families of unitary representations. We plan to do that by analyzing parabolically induced representations of a special type and determine the composition series. By doing this, we generalize many results of Speh, Tadić, Muić, Matić and Hanzer. We intend to analyze automorphic representations of global classical groups primarily using Eisenstein series, in a way that was previously used in the works of Muić and Hanzer, and some recent results of Arthur about endoscopy. From these results, we intend to get information about L-functions, and in getting those knowledge, we intend to use results obtained in our research in local theory. On the other hand, the results on the Eisenstein series can be applied on the classical modular forms. We also intend to obtain new modular forms and analyze them using Poincare series, examining non-vanishing conditions and thus generalizing previous work of Muić. Also we want to find explicit bases for the spaces of modular forms. In the research of the representations of metaplectic group, we mostly intend to focus on generic representations, and we intend to use recent results of Savin, Takeda, Lapid, Atobe and Gan about construction of local factors and  theta correspondence.]]></summary_en></project><project>
<id>7405</id><title_hr><![CDATA[Enzimska sinteza fluoriranih kiralnih građevnih blokova]]></title_hr><title_en><![CDATA[Enzymatic Synthesis of Fluorinated Chiral Building Blocks]]></title_en><user_id>19060</user_id><user_firstLast_name>Maja Majerić Elenkov</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2018-01</proposal_call><code>IP-2018-01-4493</code><acronim><![CDATA[EnzyFluor]]></acronim><duration>01.10.2018 - 30.09.2022</duration><status>Završio</status><financ_value>112.814,39 eur</financ_value><scie_area_hr>Prirodne znanosti, Biotehničke znanosti, Biomedicina i zdravstvo, </scie_area_hr><scie_area_en>Natural sciences, Biotechnical sciences, Biomedicine and health sciences, </scie_area_en><scie_field_hr>Kemija, Biologija, Biotehnologija, </scie_field_hr><scie_field_en>Chemistry, Biology, Biotechnology, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>352, 2835, 3232, 363, 28627, 858379, </team_members_id><team_members_names><![CDATA[Zvjezdana Findrik Blažević, Višnja Stepanić, Irena Dokli, Martina Sudar, Nevena Milčić, Petra Marin, ]]></team_members_names><keywords_hr><![CDATA[biokataliza, halogenhidrin-dehalogenaze, fluorirani kiralni građevni blokovi, kinetički model, molekulsko modeliranje]]></keywords_hr><keywords_en><![CDATA[biocatalysis, halohydrin dehalogenases, fluorinated building blocks, kinetical model, in sillico]]></keywords_en><summary_hr><![CDATA[Predloženi projekt usmjeren je na dizajn enzimskih transformacija kojima se polazeći iz epoksida, mogu pripraviti sintetski korisni fluorirani građevni blokovi. Halogenhidrin-dehalogenaze (HHDH), relativno nova i još uvijek nedovoljno istražena grupa enzima, koristit će se kao biokatalizatori. Fokus istraživanja će biti na procjeni utjecaja organskih otapala kao medija za provođenje ovih biotransformacija. Upotreba organskih otapala može imati prednosti u slučaju HHDH-kataliziranih reakcija. Prvenstveno se to odnosi na povećanje topljivosti i stabilnosti supstrata, što rezultira većim prinosom produkata. Ciljane transformacije su reakcije otvaranja fluoriranih derivata aril epoksida u prisutnosti natrij azida i natrij cijanida kao nukleofila. U reakcijama će se ispitati niz divljih tipova te genetski optimiziranih enzima radi odabira biokatalizatora s najboljim katalitičkim svojstvima. Korištenjem molekulskog uklapanja i metoda QM/MM odredit će se važni sterički i elektronski faktori koji utječu na katalitičku aktivnost, enantio- i/ili regioselektivnost reakcija.  Metode molekulske dinamike koristit će se i za ispitivanje utjecaja organskog otapala na strukturu, dinamiku i katalitičku aktivnost enzima. Nadalje, ispitat će se različita organska otapala u smjesi s vodom (monofazni i dvofazni sustavi) ili čista kao medij za provođenje enzimskih reakcija. Na odabranim sustavima odredit će se kinetike enzimskih reakcija, te utvrditi operacijska stabilnost enzima. Razvijeni kinetički modeli procesa će se koristiti za njihovu optimizaciju, tj. pronalaženje optimalnih radnih uvjeta kako bi se postigla maksimalna konverzija supstrata, enantiomerna čistoća produkta i/ili volumna produktivnost procesa, kao i za odabir najpovoljnijeg tipa reaktora za provedbu procesa te za uvećanje procesa. ]]></summary_hr><summary_en><![CDATA[The proposed project aims at the design of enzymatic conversions for the production of synthetically useful fluorinated chiral building blocks from epoxides. Halohydrin dehalogenases (HHDH), relatively new and still not sufficiently explored group of enzymes, will be used as biocatalysts. The strong focus will be on the evaluation of aqueous-organic solvent mixtures and pure organic solvents as reaction media. The use of organic media can offer significant advantages in the case of HHDH-catalysed transformations. In particular, it could lead to higher productivity, due to better solubility and stability of substrates. The target conversions are incorporation of cyano and azido groups through the HHDH-catalysed ring-opening reaction of fluorine-substituted aryl epoxides. The approach will be to select enzymes by screening a number of known wild-type and mutant enzymes. After the appropriate enzyme(s) and substrate(s) are selected, different organic solvents will be tested as media for the reaction, either as water-organic solvent mixtures or pure organic solvents. The important steric and electronic factors governing the catalytic activity, enantio- and / or regio-selectivity will be determined by using the molecular docking and QM/MM calculations in combination with the in silico mutagenesis study. The MD simulation in non-aqueous medium will be used for investigating the solvent effects on the structural and dynamic properties of HHDHs as well as their catalytic activity.  Furthermore, enzyme(s) will be kinetically characterized in the selected reaction media and its operational stability will be evaluated. Kinetical model of the process will be developed in order to facilitate the reaction optimization. With the use of the kinetic model it is possible to determine the best reactor type for the investigated reaction, and to find initial conditions to achieve high productivity, substrate conversion and product yield without extensive experimental work.]]></summary_en></project><project>
<id>7406</id><title_hr><![CDATA[Eksperimentalna i klinička istraživanja hipoksijsko-ishemijskog oštećenja mozga u perinatalnoj i odrasloj dobi, ZCI – Neuro, KK.01.1.1.01.0007]]></title_hr><title_en><![CDATA[]]></title_en><user_id>6256</user_id><user_firstLast_name>Nataša Jovanov Milošević</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-01</proposal_call><code>DOK-2018-01-3771</code><acronim><![CDATA[]]></acronim><duration>03.10.2018 - 30.11.2022</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb School of Medicine]]></institution_en><team_members_id>25418</team_members_id><team_members_names><![CDATA[ Doktorand: Sara Trnski ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>7408</id><title_hr><![CDATA[Cikloadicijske strategije prema policikličkim gvanidinima]]></title_hr><title_en><![CDATA[Cycloaddition strategies towards polycyclic guanidines]]></title_en><user_id>243</user_id><user_firstLast_name>Davor Margetić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2018-01</proposal_call><code>IP-2018-01-3298</code><acronim><![CDATA[CycloGu]]></acronim><duration>01.11.2018 - 31.10.2022</duration><status>Završio</status><financ_value>128.741,12 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, </scie_field_hr><scie_field_en>Chemistry, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>368, 566, 4851, 3939, 25478, 28639, 856211, </team_members_id><team_members_names><![CDATA[Zoran Glasovac, Ivana Antol, Anamarija Briš, Vjekoslav Štrukil, Akmaral Kussayeva, Luka Barešić, Petar Štrbac, ]]></team_members_names><keywords_hr><![CDATA[organska sinteza, cikloadicije, gvanidini, bazičnost, kvantno-kemijski računi]]></keywords_hr><keywords_en><![CDATA[organic synthesis, cycloadditions, guanidines, basicity, quantum-chemical calculations]]></keywords_en><summary_hr><![CDATA[Znanstveni pristup projekta temelji se na kombinaciji eksperimentalnih i teorijskih istraživanja. Projekt obuhvaća organsku kemijsku sintezu, fizikalno-kemijsku karakterizaciju novih organskih molekula, kao i kvantno-kemijske proračune i molekularno modeliranje.Cilj projekta je istražiti inherentna fizikalno-kemijska svojstva (poli)cikličnih gvanidina u kojima je barem jedan atom dušika ugrađen u heterociklički prsten ili vezan za policikličke strukture. Ciljevi su: a) Sinteza (poli)cikličkih molekularnih sustava koji posjeduju gvanidinske funkcionalnosti primjenom ekološki prihvatljivih sintetskih metoda (s naglaskom na cikloadicijske rakcije) i njihovu spektroskopsku i strukturnu karakterizaciju; b) Mehanističke studije primijenjenih reakcija; c) Detaljni uvid u temeljne molekularne mehanizme kako inkorporiranje gvanidinske funkcionalnosti u cikličke strukture posreduje svojstvu superbazičnosti; d) Razvoj modelnih cikličkih gvanidinskih sustava za anionsko prepoznavanje; e) Uporaba cikličkih gvanidinskih sustava u razvoju bazne katalize.Rezultati temeljnih studija provedenih u okviru ovog projekta poboljšat će razumijevanje fizikalno-kemijskih čimbenika koji upravljaju superbazičnosti u cikličkim sustavima i unaprijediti njihov dizajn. Očekivani rezultati omogućuju dizajn i pripravu novih cikličkih gvanidinskih sustava koji bi se mogli primijeniti u različitim istraživačkim područjima, uključujući anionsko prepoznavanje i homogenu katalizu, sintezu prirodnih produkata i bioaktivnih molekula.]]></summary_hr><summary_en><![CDATA[The scientific approach of the project is based on a combination of experimental and theoretical investigations. Project encompasses organic chemical synthesis, physico-chemical characterization of novel organic molecules, as well as quantum-chemical calculations and molecular modelling.The goal of the project is to investigate inherent physico-chemical properties of (poly)cyclic guanidines in which at least one nitrogen atom is embedded in heterocycle or attached to polycyclic structures. The objectives are: a) Synthesis of (poly)cyclic molecular systems possessing guanidine functionalities by employment of environmentally friendly synthetic methods (with the emphasize on cycloaddition reactions) and their spectroscopic and structural characterization; b) Mechanistic studies of reactions employed; c) Detailed insight into the fundamental molecular mechanisms how incorporation of guanidine moiety in cyclic structures mediates superbasicity properties; d) Development of model cyclic guanidine systems for anion sensing; e) Utilization of cyclic guanidine systems in development of base catalysis.The results of fundamental studies carried out within this project will enhance the understanding of physico-chemical factors governing superbasicity in cyclic systems and advance their design. Expected results will enable design and preparation of novel cyclic guanidine systems which could be applied in different research areas including anion sensing and homogeneous catalysis, synthesis of natural products and bioactive molecules.]]></summary_en></project><project>
<id>7419</id><title_hr><![CDATA[EVOLUCIJSKA SINTEZA OBLIKA S INTEGRALNIM I PARTICIONIRANIM 3D FENOTIPOVIMA, DINAMIČKOM PARAMETRIZACIJOM I BEZMREŽNIM MODELIRANJEM]]></title_hr><title_en><![CDATA[EVOLUTIONARY SHAPE SYNTHESIS WITH INTEGRAL AND PARTITINED 3D PHENOTYPES, DYNAMIC PARAMETERIZATIONS AND MESHLESS MODELING ]]></title_en><user_id>3851</user_id><user_firstLast_name>Damir Vučina</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2018-01</proposal_call><code>IP-2018-01-6774</code><acronim><![CDATA[Synth3D]]></acronim><duration>01.12.2018 - 30.11.2022</duration><status>Završio</status><financ_value>108.845,98 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Temeljne tehničke znanosti, Računarstvo, Strojarstvo, Interdisciplinarne tehničke znanosti, </scie_field_hr><scie_field_en>Basic engineering sciences, Computer sciences, Mechnical engineering, Interdisciplinary technological sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Splitu, Fakultet elektrotehnike, strojarstva i brodogradnje]]></institution_hr><institution_en><![CDATA[University of Split, Faculty of Electrical Engineering, Mechanical Engineering and Naval Architecture]]></institution_en><team_members_id>23786, 13265, 13396, 4873, 4969, 4871, 5150, 4983, 21278, </team_members_id><team_members_names><![CDATA[Miro Bugarin, Ivo Marinić-Kragić, Milan Ćurković, Damir Sedlar, Igor Pehnec, Ivan Tomac, Željan Lozina, Zoran Milas, Anđela Bartulović, ]]></team_members_names><keywords_hr><![CDATA[Sinteza oblika, Evolucijska optimizacija, Učinkovita parametrizacija, Heterogeni fenotipovi, Particioniranje, Izogeometrijsko modeliranje]]></keywords_hr><keywords_en><![CDATA[Shape synthesis, Evolutionary optimization, Efficient parameterization, Heterogeneous phenotypes, Partitioning, Isogeometric modelling]]></keywords_en><summary_hr><![CDATA[Projekt nastavlja prethodni dvogodišnji HRZZ projekt koji je rezultirao u šest publikacija u prestižnim časopisima te planira razvoj generičke platforme za optimizacijski baziranu sintezu 3D oblika temeljenu isključivo na danim kriterijima izvrsnosti i ograničenjima, uključujući:- fazu apstraktne inicijalizacije (geneza 3D oblika) s uklanjanjem pristranosti prema bilo kojem obliku ili pojedinim sastavima geometrijskih primitiva- nasljeđivanje i uključivanje oblika postojećih objekata temeljenih na 3D skeniranju u oblake 3D točaka- evolucijsku optimizaciju oblika populacija heterogenih fenotipova pretvorenih u zajedničke genotipove na temelju parametarskog fitanja- dinamičku parametrizaciju koja obuhvaća čak i dramatično promjenjive 3D oblike temeljenu na inteligentnoj prilagodbi postojećim geometrijskim značajkama- 3D oblike konceptualno modelirane i kao integralne entitete i kao skupove particija s kodiranim međusobnim relacijama- razvoj opcija za detekciju značajki (npr. rubovi, vrhovi) u integralnim geometrijama za dekompoziciju optimiranog oblika,- konceptualni razvoj procesa post-optimizacije oblika integralnih oblika u smislu potencijalnog predstavljanja kao skupa djelomičnih particija oblika,- implementaciju izogeometrijske analize (IGA) u fazama analize polja za ograničenja i ciljne funkcije (izogeometrijske i bezmrežne metode bi mogle učinkovito podržati optimizaciju oblika uz istu infrastrukturu za analizu polja sa ograničenjima i za promjene oblika)- primjenu IGA u strategijama optimizacije uz iste baze uključene u parametrizaciju oblika i tražene izračune polja, što smanjuje utrošak vremena u prijenosu podataka.Projekt će razviti računalne radne tokove koji efikasno implementiraju gornje elemente te ih sustavno testirati. Proučit će se nekoliko teorijskih i stvarnih testnih slučajeva, a ad-hoc aerodinamički tunel će biti nadograđen za komparativnu eksperimentalnu verifikaciju optimiziranih oblika vjetroturbina s vertikalnom osi.]]></summary_hr><summary_en><![CDATA[The project continues the former two-year CSF project which resulted in six publications in prestigious journals and aims at developing a generic platform for optimization-based synthesis of 3D shape based solely on given excellence criteria and constraints, involving: - an abstract initiation phase (3D shape genesis) with elimination of bias towards any candidate shapes or particular compositions of geometric primitives- inheriting and import of shapes of existing objects based on 3D scanning into point clouds,- evolutionary shape optimization of populations of heterogeneous phenotypes converted into common genotypes based on parametric fitting- dynamic parameterization to encapsulate even dramatically changing 3D shapes based on intelligent adaptation to current shape features- 3D shapes conceptually modelled both as integral entities and sets of partitions with coding of mutual relationships- options for feature-detection approaches (e.g. edges, peaks) in integral geometries towards shape decomposition of optimized shape- conceptual development of post-shape-optimization processing of integral shapes in terms of potential representation as sets of partial shape entities,- implementation of isogeometric analysis (IGA) in the field analysis stages towards constraints and objective functions (isogeometric and meshless procedures could efficiently support shape optimisation using the same infrastructure in constraint dependent field analysis and reshaping)- application of IGA in optimisation strategies with the same basis involved in shape parameterization and field calculations, thereby reducing time consumption in data transfers.The project will develop computational workflows which efficiently implement above elements and systematically test them. Several theoretical and actual test-cases will be studied, and the ad-hoc aerodynamic tunnel will be upgraded for comparative experimental verification of optimized shapes of vertical-axis wind turbines.]]></summary_en></project><project>
<id>7422</id><title_hr><![CDATA[Rasvijetljavanje mehanizama rezistencije na terapiju raka debelog crijeva sa mutacijom BRAF pomoću integriranog -omics pristupa]]></title_hr><title_en><![CDATA[Dissecting the mechanisms of therapy resistance in BRAF-mutant colon cancer using an integrated –omics approach]]></title_en><user_id>3261</user_id><user_firstLast_name>Mirela Sedić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2018-01</proposal_call><code>IP-2018-01-3900</code><acronim><![CDATA[BRAFCON]]></acronim><duration>15.01.2019 - 14.01.2023</duration><status>Završio</status><financ_value>131.568,12 eur</financ_value><scie_area_hr>Prirodne znanosti, Biomedicina i zdravstvo, Interdiciplinarne znanosti, </scie_area_hr><scie_area_en>Natural sciences, Biomedicine and health sciences, Interdisciplinary scientific area, </scie_area_en><scie_field_hr>Interdisciplinarne prirodne znanosti, Biologija, Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Interdisciplinary natural sciences, Biology, Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Institut za antropologiju]]></institution_hr><institution_en><![CDATA[Institute for Anthropological Research]]></institution_en><team_members_id>19745, 23360, 7807, 12407, 19203, 28696, </team_members_id><team_members_names><![CDATA[Thomas Eichmann, Olga Vasieva, Djuro  Josic, Elitza Petkova Markova-Car, Petra Grbčić, Iris Car, ]]></team_members_names><keywords_hr><![CDATA[BRAF, rak debelog crijeva, kemorezistencija, proteomika, sfingolipidomika, sektretom stanica raka]]></keywords_hr><keywords_en><![CDATA[BRAF, colon cancer, chemoresistance, proteomics, sphingolipidomics, cancer secretome]]></keywords_en><summary_hr><![CDATA[Kolorektalni karcinom (CRC) je treće po redu najčešće dijagnosticirano maligno oboljenje i četvrti vodeći uzrok smrtnosti povezane s rakom na globalnoj razini. Zahvaljujući naprecima u sistemskoj kemoterapiji, ciljanim terapijama i kirurškim tehnikama, preživljenje pacijenata s metastatskim CRC se poboljšalo u posljednja dva desetljeća. Unatoč tome, napreci u terapiji nisu unaprijedili liječenje svih molekularnih podtipova CRC. Ovo se naročito odnosi na populaciju CRC pacijenata sa BRAFV600E mutacijom (7–10%) koji slabo odgovaraju na većinu sistemske terapije i imaju vrlo lošu prognozu. Vemurafenib, protein kinazni inhibitor BRAFV600E kojeg je FDA odobrila za liječenje metastatskog melanoma sa BRAFV600E mutacijom, unio je nadu u liječenje BRAF-mutiranog CRC. Međutim, suprotno rezultatima dobivenim kod melanoma sa BRAFV600E mutacijom, monoterapija vemurafenibom je pokazala limitiranu kliničku učinkovitost u CRC pacijenata sa BRAFV600E mutacijom. Kako bi se poboljšali ishodi liječenja CRC pacijenata sa BRAFV600E mutacijom, potrebno je bolje razumjeti mehanizme rezistencije na BRAF inhibitore. Projekt BRAFCON će rasvijetliti procese koji vode ka razvoju rezistencije na BRAF inhibiciju vemurafenibom u stanicama raka debelog crijeva sa BRAFV600E mutacijom tako što će omogućiti integraciju različitih slojeva molekularne informacije (proteom, glikoproteom, sekretom i sfingolipidom) uzevši u obzir složenu interakciju između molekularnih signala unutar i izvan stanica raka debelog crijeva koji utječu na brojne aspekte staničnog ponašanja. Bioinformatička analiza i integracija –omics podataka će otkriti nove markere i mete rezistencije omogućujući tako dizajniranje nove kombinirane strategije za prevladavanje terapijske rezistencije na vemurafenib koja će potom biti validirana in vitro. Na taj će način BRAFCON doprinjeti razvoju novih modaliteta liječenja oboljelih od raka debelog crijeva sa BRAF mutacijom. ]]></summary_hr><summary_en><![CDATA[Colorectal cancer (CRC) is the third most commonly diagnosed malignancy and the fourth leading cause of cancer-related deaths in the world. Owing to the improvements in systemic chemotherapy, targeted therapies and surgical techniques, the survival of patients with metastatic CRC (mCRC) has improved over the past two decades. Still, these therapeutic advances have not brought benefit to all molecular subtypes of CRC. This particularly holds true for the population of mCRC patients with BRAFV600E mutation (7–10%) which have poor response to most systemic therapies and a very poor prognosis. Vemurafenib, a protein kinase inhibitor of BRAFV600E approved by the FDA for the treatment of metastatic melanoma with BRAFV600E mutation, has raised hopes of treatment for BRAF-mutant CRC. However, opposite to the results seen in patients with BRAFV600E mutant melanoma, single-agent vemurafenib exerted limited clinical efficacy in patients with BRAFV600E mutant CRC. In order to improve outcomes in CRC patients with BRAF mutation, there is a critical need to better understand the mechanisms of resistance to BRAF inhibitors. The BRAFCON project strives to give a new perspective on the processes governing acquired resistance to BRAF inhibition by vemurafenib in BRAFV600E mutant colon cancer cells by integrating different layers of molecular information (proteome, glycoproteome, secretome and sphingolipidome) while taking into account an intricate interplay of molecular signals both, inside and outside of colon cancer cells that influence multiple aspects of cell behaviour.  Bioinformatics analysis and integration of –omics data would reveal novel resistance markers and targets guiding the design of new combinatorial strategy to counter therapeutic resistance to vemurafenib in BRAF-mutant colon cancer cells, which will be validated in vitro. In this way, BRAFCON will contribute to the development of new treatment modalities for BRAF-mutant colon cancer patients.  ]]></summary_en></project><project>
<id>7428</id><title_hr><![CDATA[Genotipska specifičnost pšenične trave (Triticum aestivum L.) visokonutritivnog prirodnog dodatka prehrani]]></title_hr><title_en><![CDATA[]]></title_en><user_id>22586</user_id><user_firstLast_name>Miroslav Lisjak</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-01</proposal_call><code>DOK-2018-01-1672</code><acronim><![CDATA[WHEAT4GRASS]]></acronim><duration>24.10.2018 - 31.12.2022</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Poljoprivreda, </scie_field_hr><scie_field_en>Agriculture, </scie_field_en><institution_hr><![CDATA[Sveučilište Josipa Jurja Strossmayera u Osijeku, Fakultet agrobiotehničkih znanosti Osijek]]></institution_hr><institution_en><![CDATA[Josip Juraj Strossmayer University of Osijek, Faculty of Agrobiotechnical Sciences in Osijek]]></institution_en><team_members_id>25321</team_members_id><team_members_names><![CDATA[ Doktorand: Marija Kristić ]]></team_members_names><keywords_hr><![CDATA[pšenična trava, in vitro bioraspoloživost, antioksidacijska aktivnost, obogaćeni proizvod, biofortifikacija, nutraceutik]]></keywords_hr><keywords_en><![CDATA[wheatgrass, in vitro bioavailability, antioxidative activity, enriched food, biofortification]]></keywords_en><summary_hr><![CDATA[Podizanjem svijesti o važnosti zdrave prehrane sve je veća potražnja za funkcionalnom hranom. Najjednostavniji oblik funkcionalne hrane su namirnice koje prirodno imaju visok sadržaj tvari s pozitivim utjecajem na zdravlje ljudi. Takva namirnica je pšenična trava (Triticum aestivum L.) koja se u obliku svježeg soka ili praha koristi kao dodatak prehrani. Pšenična trava predstavlja mlade izdanke vrsta roda Triticum koji u velikim količinama sadrže klorofil, bioflavonoide, esencijalne aminokiseline, vitamine, minerale i antioksidante. Zbog svog sastava pšenična trava ima značajan pozitivna utjecaj na detoksikaciju organizma, jačanje imuniteta i cijeli niz akutnih oboljenja. Ciljevi predloženog istraživanja su (1) ispitati genotipsku specifičnost pšenične trave s obzirom na in vitro bioraspoloživost Zn, Fe, Se, Mn, Mg, Ca, K i Na, antioksidacijsku aktivnost te sadržaj kloroplastnih pigmenata, (2) ispitati utjecaj biofortifikacije cinkom i selenom na mineralni sastav, antioksidacijsku aktivnost i sadržaj kloroplasta, (3) izdvojiti genotipove pšenice za uzgoj pšenične trave koji će se moći preporučiti za direktnu uporabu kao dodatak prehrani, (4) ispitati antiproliferativni učinak ekstrakata pšenične trave na humanim tumorskim staničnim linijama. Ispitivanje genotipske specifičnosti provest će sa na 100 genotipova pšenice različitog podrijetla te će se izabrati genotipovi na kojima će se ispitivati utjecaj biofortifikacije selenom i cinkom na ispitivana svojstva pšenične trave. Antiproliferativni učinak ekstrakata pšenične trave ispitat će se na 5 humanih tumorskih staničnih linija. Predloženo istraživanje rezultirat će saznanjima značajnima hrvatskoj i međunarodnoj znanstvenoj zajednici, jer istraživanje pšenične trave ovakvog tipa i ovakvog obima još nije provedeno. Prema našim saznanjima, prva smo istraživačka skupina u Republici Hrvatskoj koje će se baviti istraživanjima na pšeničnoj travi.]]></summary_hr><summary_en><![CDATA[Raising awareness on the importance of healthy diet has increase demand for functional food. In their simplest form, functional food is a food that naturally possess substances that positively affect people&#39;s health. Wheatgrass (Triticum aestivum L.) is such food. Wheatgrass can be utilized as a dietary supplement in the form of fresh juice or powder made from young shoots of species of the genus Triticum. It contains chlorophyll, bioflavonoids, essential amino acids, vitamins, minerals and antioxidants in high quantities. Because of its composition, wheatgrass has a significant positive effect on detoxification of the body, strengthening of immunity and on a full range of acute illnesses. In the proposed study we will investigate (1) the genotype specificity of wheatgrass regarding the in vitro bioavailability of Zn, Fe, Se, Mn, Mg, Ca, K and Na, antioxidant activity and chloroplast pigment content, 2) the influence of zinc and selenium biofortification on mineral composition, antioxidant activity and content of chloroplast pigments; (3) select wheatgrass genotypes for cultivation and for recommendation for usage in the form of powder or fresh juice, (4) the antiproliferative effect of wheatgrass extracts on human tumor cell lines. A genotype specificity will be tested on a set of 100 wheat genotypes of different origin. Based on the results of genotype specificity testing, 10 genotypes will be selected for investigation of the effect of zinc and selenium biofortification on examined traits in wheatgrass. Investigation of the antiproliferative effect of wheat grass extracts will be performed on 5 human tumor cell lines. The proposed research will result in findings that are significant to the Croatian and international scientific community. Research of this type and this scope on wheatgrass has not been carried out yet. According to our knowledge, we are the first research group in the Republic of Croatia that will research nutraceutical properties of wheatgrass.]]></summary_en></project><project>
<id>7429</id><title_hr><![CDATA[Pouzdani kompozitni primjenski sustavi zasnovani na web uslugama]]></title_hr><title_en><![CDATA[Reliable Composite Applications Based on Web Services]]></title_en><user_id>7793</user_id><user_firstLast_name>Siniša Srbljić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2018-01</proposal_call><code>IP-2018-01-6423</code><acronim><![CDATA[RELS]]></acronim><duration>01.12.2018 - 30.11.2022</duration><status>Završio</status><financ_value>119.408,59 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Računarstvo, </scie_field_hr><scie_field_en>Computer sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id>12997, 12993, 11194, 22589, 27127, </team_members_id><team_members_names><![CDATA[Marin Šilić, Klemo Vladimir, Goran Delač, Adrian Satja Kurdija, Lucija Šikić, ]]></team_members_names><keywords_hr><![CDATA[kvaliteta usluge, predviđanje, web usluge, odabir usluga, kompozicija usluga]]></keywords_hr><keywords_en><![CDATA[QoS, Prediction, Web Services, Services Selection, Services Composition]]></keywords_en><summary_hr><![CDATA[U posljednjih nekoliko godina sveprisutne su postale različite platforme zasnovane na računarstvu u oblaku. Korištenje udaljenih usluga omogućava računalno rasterećenje te dobiva sve veći značaj s popularizacijom različitih komercijalnih sustava zasnovanih na konceptu Interneta stvari. Jedan od glavnih istraživačkih izazova u računarstvu zasnovanom na uslugama jest pouzdanost web usluga. Web usluge su primjenski sustavi postavljeni na Internetu koji svoje funkcionalnosti pružaju putem javno dostupnih i poznatih sučelja. Posljedica je da se kvalitetom usluge (QoS) ne može upravljati s aspekta korisnika obzirom da korisnik nema izravnu kontrolu nad trenutnim stanjem okoline unutar koje se usluga izvršava i nema uvid u različita nefunkcijska svojstva komunikacijskog kanala. Ovaj projekt fokusiran je na dvije osnovne teme u području pouzdanosti računarstva zasnovanog na uslugama. Prva tema pokriva područje predviđanja QoS parametara atomarnih web usluga. Predviđanje je popularna metoda procjene QoS parametara web usluga jer tradicionalni koncept mjerenja nije primjenjiv zbog degradacije radnih svojstava web usluge. Konkretno, aktivnosti u okviru prve teme fokusirane su na predviđanje QoS parametara uz poznavanje konteksta unutar kojeg se poziv odvija. Bolje poznavanje konteksta poziva web usluge omogućuje bolju procjenu QoS parametara. Druga tema istraživanja bavi se problemom odabira usluga prilikom izgradnje kompozitnih primjenskih sustava. Kompozitni primjenski sustavi izgrađeni su od atomarnih usluga gdje svaka usluga pruža određenu funkcionalnost. Međutim, u praksi često postoji više različitih instanci usluga koje pružaju željenu funkcionalnost. Tada se odabir pojedine instance u kompoziciji zasniva na analizi ostalih nefunkcijskih svojstava. U okviru projekta fokus će biti na oblikovanju učinkovitih i preciznih algoritama za odabir prikladnih instanci atomarnih usluga u trenutku izvršavanja kompozitnog primjenskog sustava.]]></summary_hr><summary_en><![CDATA[Recent years have brought a rapid adoption of platforms based on computing in the cloud. Consumption of remote services that enable computational offloading has gained traction as various systems based on the Internet of Things (IoT) concept are becoming increasingly popular. One of the main research concerns in service-oriented computing is the question of maintaining a reliable execution environment. Services are self-contained applications deployed on remote servers which can be consumed using well-established interfaces. Thus, the Quality of Service (QoS) cannot be maintained by the service consumer as it does not have the direct control over the execution environment nor does it have control over the parameters influencing the non-functional properties of the communication channel.This project focuses on two major problems in the area of dependable service computing. The first topic covers the issues of predicting the QoS parameters of atomic web services. Prediction is one of the popular methods to estimate the QoS parameters as active measurements can lead to degradation of service quality. More specifically, the project activates are focused on context-aware QoS prediction that gives estimation of QoS properties as seen by the service consumer. The other portion of research efforts of this project is focused at service selection. It is often the case that atomic services are used as building blocks to create more complex composite applications. In such cases, each atomic service has the purpose of handling a specific functional requirement of the application. However, multiple different web services that meet specific functional properties can be available. In such an environment it is possible to select a service with more favorable QoS properties during runtime. This project focuses on developing efficient and accurate algorithms that can perform atomic service selection at the time of service composition invocation.]]></summary_en></project><project>
<id>7434</id><title_hr><![CDATA[H2020-MSCA-RISE-2015: Advanced physical-acoustic and psycho-acoustic diagnostic methods for innovation in building acoustics (papabuild)]]></title_hr><title_en><![CDATA[]]></title_en><user_id>19019</user_id><user_firstLast_name>Marko Horvat</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-01</proposal_call><code>DOK-2018-01-4147</code><acronim><![CDATA[]]></acronim><duration>22.10.2018 - 21.10.2022</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Elektrotehnika, </scie_field_hr><scie_field_en>Electrical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id>25352</team_members_id><team_members_names><![CDATA[ Doktorand: Dominik Kisić ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>7435</id><title_hr><![CDATA[TFF3 protein na raskrižju metabolizma i neurodegeneracije]]></title_hr><title_en><![CDATA[]]></title_en><user_id>1263</user_id><user_firstLast_name>Mirela Baus Loncar</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-01</proposal_call><code>DOK-2018-01-2572</code><acronim><![CDATA[Inter MeNe-3]]></acronim><duration>10.10.2018 - 09.12.2022</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>25290</team_members_id><team_members_names><![CDATA[ Doktorand: Iva Bazina ]]></team_members_names><keywords_hr><![CDATA[Tff3 protein, jetra, mozak, diabetes, neurodegeneracija, Alzheimerova bolest homeostaza  glukoze, stres endoplazmatskog retikuluma  ]]></keywords_hr><keywords_en><![CDATA[Tff3 protein, liver, brain, diabesity, neurodegeneracija, Alzheimer disasese, glucose homeostasis, endoplasmatic reticulum (ER) stress  ]]></keywords_en><summary_hr><![CDATA[Većina bolesti koje prate užurbani životni ritam su povezane sa poremećenim metabolizmom glukoze i lipida. Diabetes i Alzheimerova bolest (AB) su među najvećim prijetnjama današnjice. Obje bolesti  u podlozi imaju neosjetljivost na inzulin i zajedničke upalne signalne putove. Kliničke i pred kliničke studije pokazale su  da je AB degenerativna metabolička bolest, posredovana narušenim inzulinskim signaliziranjem u mozgu, poremećenim iskorištenjem glukoze i energetskog metabolizma koji dovode do oksidativnog stresa, upale i pogoršanja inzulinske  neosjetljivosti. Veza između diabetes/debljine i AB, može razjasniti mehanizam nastanka sporadične AB koja se javlja kod 90% AB pacijenata. Potraga za biomarkerima u likvoru  AB pacijenata otkrila  je  TFF3 protein (Trefoil factor family protein 3) kao mogućeg povezujućeg kandidata. Nova istraživanja pokazala su da bolest nealkoholna masna jetra izazvana masnom hranom u mišjem modelu može uzrokovati sve simptome AB uključujući i smrt neurona. Dramatično smanjenje razine Tff3 glasničke RNA u jetri uočena je u ranoj fazi diabetesa kod mišjeg modela diabetes Tipa 2 (Tally Ho). Tff3 protein je prisutan u neuronima a Tff3 iz jetre može djelovati neuroprotektivno i nakupljati se u mozgu nakon ozljede. Cilj ovog projekta je utvrditi ulogu Tff3 proteina u Jetri/mozgu koristeći Tff3 -/- mišji soj i modelirajući diabetesa tipa 1 i tipa 2. Korelirati ćemo učinak nedostatka Tff3 na jetru kao glavni metabolički organ i mozak (hippocampus/cortex),te pratiti specifične pokazatelje neurodegeneracije i stresa endoplazmatskog retikuluma. Koristeći novu tehnologiju (XFe96 Extracellular Flux Analyzer) utvrdit ćemo učinak Tff3 na mitohondrijsku respiraciju i glikolizu u živućim primarnim hepatocitima. Ovakav sistemski pristup pridonijeti će razumijevanju zajedničkih procesa koji se odvijaju u osnovi obje bolesti (diabetesa i neurodegeneracije), te potencijalno ukazati na nove terapijske mete. ]]></summary_hr><summary_en><![CDATA[Most of the diseases accompanying fast  life rhythm in developed countries are connected with  deregulated  lipid and glucose metabolism. Diabetes and Alzheimer’s disease (AD) are considered among top threats to human health and they both have in common insulin resistance and common inflammatory signaling pathways. Human and preclinical studies have provided convincing evidence that AD is a degenerative metabolic disease, mediated by impaired insulin responsiveness in the brain, glucose utilization and energy metabolism leading to increased oxidative stress, inflammation and worsening of insulin resistance. The connection between diabetes/obesity and AD, may shed light how sporadic AD develops. Biomarker search in cerebrospinal fluid of  AD  patients  identified  TFF3 protein as a new  possible candidate for this crosstalk. Novel research showed that non-alcoholic fatty liver disease provoked by High fat diet is able to induce hallmarks of AD and even neuronal death in wild type mice. Diminishment of liver Tff3 gene expression was noticed in early stage of diabetes in Tally Ho mouse model of Type 2 diabetes. Tff3 protein is present in neurons and liver produced Tff3 can act neuroprotective and concentrate in brain upon injury. In this project  proposal we will investigate impact of Tff3 protein in liver/brain axis using  Tff3 -/- mouse strain and modeling Type 1 and Type 2 diabesity conditions. We will correlate  the effect  of Tff3 deficiency on liver as major metabolic organ,  and hippocampus/cortex as affected brain regions is AD, monitoring neurodegenerative hallmarks and endoplasmatic reticulum stress markers. Using novel technology (XFe96 Extracellular Flux Analyzer) we will estimate impact of Tff3 on mitochondrial respiration and glycolysis in living primary hepatocytes. This systemic approach will help us understand common pathways in diabesity and neurodegeneration and possibly reveal novel therapeutic targets. ]]></summary_en></project><project>
<id>7438</id><title_hr><![CDATA[Višegodišnje i dekadne oscilacije Jadranskog mora: opažanja, modeliranje  i posljedice]]></title_hr><title_en><![CDATA[]]></title_en><user_id>195</user_id><user_firstLast_name>Ivica Vilibić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-01</proposal_call><code>DOK-2018-01-7511</code><acronim><![CDATA[ADIOS]]></acronim><duration>11.07.2018 - 30.11.2022</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Geofizika, </scie_field_hr><scie_field_en>Geophysics, </scie_field_en><institution_hr><![CDATA[Institut za oceanografiju i ribarstvo]]></institution_hr><institution_en><![CDATA[Institute of Oceanography and Fisheries]]></institution_en><team_members_id>25204</team_members_id><team_members_names><![CDATA[ Doktorand: Petra Zemunik ]]></team_members_names><keywords_hr><![CDATA[Jadransko more, višegodišnje i dekadske oscilacije, stvaranje guste vode, BIOS, združeno klimatsko modeliranje atmosfere i mora]]></keywords_hr><keywords_en><![CDATA[Adriatic Sea, interannual and decadal oscillations, dense water formation, BIOS regimes, coupled atmosphere/ocean climate modelling]]></keywords_en><summary_hr><![CDATA[Glavni cilj projekta Adios je istražiti i kvantificirati procese koji pogone međugodišnje i desetljetne termohaline varijacije u jadransko-jonskom bazenu. Cilj će se postići (i) dokumentiranjem međugodišnje i desetljetne varijabilnosti analizom dugoročnih oceanografskih mjerenja i postojećih klimatskih modela, (ii) istraživanjem kratkoročnih i dugogodišnjih procesa koji pokreću jadransko-jonsku termohalinu cirkulaciju, u prvom redu stvaranje guste vode u Jadranu i BIOS-a (Bimodalna jadransko-jonska oscilacija), i (iii) procjenom prošle i buduće jadranske klime i varijabilnosti primjenom jadranskog združenog (atmosfera-more) klimatskog modela visoke razlučivosti. Iako se odavno zna da je međugodišnja i desetljetna termohalina promjenjivost dominantna u Jadranu, odgovarajuća teorija (BIOS) razvijena je tek nedavno, te još uvijek nije ispravno reproducirana od strane oceanskih numeričkih modela. Stoga će se u okviru ADIOS projekta postaviti i pokrenuti ugniježđeni združeni klimatski model visoke rezolucije u području Jadrana. Nakon verifikacije nad mjerenjima, model će se primijeniti na buduću klimu koristeći nekoliko IPCC scenarija. Takav pristup omogućit će preciznu procjenu budućih klimatskih promjena na Jadranu, uključujući i višegodišnju i desetljetnu varijabilnost i regulirajuće procese, što će biti temelj za procjenu klimatskih rizika na nacionalnoj i regionalnoj razini. Značajan projektni napor će se posvetiti nastavku mjerenja na Palagruškom oceanografskom profilu, najdužem sezonski uzorkovanom oceanografskom transektu na Sredozemlju u trajanju od oko 60 godina, ali vrlo rijetko uzorkovanom nakon 2013. godine. ADIOS projekt će imati snažnu međunarodnu komponentu koja uključuje priznate oceanografske institute (OGS, CNRS-GAME), te njihove istraživače aktivno uključene na predviđena projektna istraživanja, što će rezultirati povećanjem kapaciteta, umreženosti i učinkovitosti hrvatske oceanografske i klimatske zajednice.]]></summary_hr><summary_en><![CDATA[The major objective of the ADIOS project is to investigate and to quantify processes driving interannual to decadal thermohaline variations in the Adriatic-Ionian basin. This objective will be achieved by (i) documenting interannual to decadal variability from long-term oceanographic series and existing climate models, (ii) investigating short- and long-time processes that drive the Adriatic-Ionian thermohaline circulation, primarily the Adriatic dense water formation and the BiOS (Adriatic-Ionian Bimodal Oscillating System), and (iii) assessing past and future Adriatic climate and variability from the Adriatic-adopted high-resolution atmosphere/ocean climate model runs. Although interannual to decadal thermohaline variability is known to be dominant in the Adriatic, the respective theory (cf. BIOS) has been developed very recently and is still not properly reproduced and verified by ocean numerical models. To tackle this, the Adriatic climate run will be setup and executed through nesting of state-of-the-art high-resolution atmospheric/ocean models into the Mediterranean runs. Once validated for a 30 year hindcast time period, the Adriatic model will be used in forecast mode for several IPCC scenarios. Such an approach will allow for better assessment of future climate changes in the Adriatic, including interannual to decadal variability and governing processes. These simulations will be a base for an upgrade in climate hazard assessment on national and basin levels. A significant project effort will be dedicated to continuation of the Palagruža Sill oceanographic transect, the longest seasonally-sampled transect in the Mediterranean, lasting over 60 years but very sparsely sampled since 2013. The project will have a strong international component, incorporating recognized institutes (OGS, CNRS-GAME) and their researchers to the ADIOS research and therefore increasing capacities, networks and efficiency of the Croatian oceanographic and climate communities.]]></summary_en></project><project>
<id>7441</id><title_hr><![CDATA[Molekularni mehanizam neurodegeneracije u Niemann-Pickovoj bolesti tip C]]></title_hr><title_en><![CDATA[]]></title_en><user_id>4828</user_id><user_firstLast_name>Silva Katušić Hećimović</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-01</proposal_call><code>DOK-2018-01-7587</code><acronim><![CDATA[neuroNiPiC]]></acronim><duration>09.10.2018 - 09.12.2022</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>25281</team_members_id><team_members_names><![CDATA[ Doktorand: Ana Rastija ]]></team_members_names><keywords_hr><![CDATA[Alzheimerova bolest, Aß, APP, BACE1, kolesterol, neurodegeneracija, neuroinflamacija, Niemann-Pickova bolest tip C, NPC1, tau]]></keywords_hr><keywords_en><![CDATA[Alzheimer’s disease, Aß, APP, BACE1, cholesterol, neurodegeneration, neuroinflammation, Niemann-Pick type C disease, NPC1, tau]]></keywords_en><summary_hr><![CDATA[Niemann-Pickova bolest tip C (NPC) je rijetka dječja progresivna neurodegenerativna bolest koju karakterizira nakupljanje kolesterola, gubitak Purkinjeovih neurona u cerebelumu, hiperfosforilacija proteina tau i značajna neuroinflamacija. Intrigantno je da ova rijetka nasljedna bolest (uzrokovana mutacijama u genu NPC1 ili NPC2) pokazuje niz značajki kompleksne Alzheimerove bolesti (AB). Međutim, ove neurodegenerativne bolesti pokazuju različitu „ranjivost“ regija mozga; hipokampus je primarno oštećen u AB, dok je pošteđen u bolesti NPC, a cerebelum je pošteđen u AB, dok je primarno zahvaćen u bolesti NPC. U ovom projektu ćemo primijeniti saznanja opsežnih istraživanja proteolitičke razgradnje proteina prekursora peptida amiloid-ß (APP) u najčešćoj neurodegenerativnoj bolesti AB s ciljem razumijevanja molekularnog mehanizam neurodegeneracije u rijetkoj bolesti NPC. Potaknuti našim nedavnim otkrićem da jedan od glavnih enzima AB ß-sekretaza (BACE1) povećano cijepa protein APP u bolesti NPC, ispitat ćemo ulogu proteolize enzimom BACE1 u patogenezi bolesti NPC i može li BACE1 predstavljati novu ciljnu molekulu za tretiranje/ublažavanje bolesti NPC. U hipokampusu i cerebelumu NPC1- i wt-miševa ispitat ćemo proteolizu i distribuciju APP kao i dva nedavno otkrivena isključiva supstrata za BACE1. Primarne kulture neurona hipokampusa i Purkinjeovih neurona cerebeluma ćemo upotrijebiti za otkrivanje mehanizma učinka BACE1 na patološke značajke NPC bolesti. Također, razvit ćemo ex vivo model bolesti NPC korištenjem organotipskih kultura moždanih rezova hipokampusa i cerebeluma te ćemo pratiti utjecaj inhibicije BACE1 na prevenciju/ublažavanje patoloških značajki bolesti NPC. Konačno, generirat ćemo mišji model NPC1 u kojem ćemo ukloniti gen BACE1 za potvrdu dobivenih rezultata in vivo. Ova istraživanja će ukazati na ulogu BACE1 u patogenezi NPC bolesti i na potencijalno ciljanje enzima BACE1 kao alternativnog pristupa liječenja ove još uvijek neizlječive bolesti.]]></summary_hr><summary_en><![CDATA[Niemann-Pick type C disease (NPC) is a rare childhood progressive neurodegenerative disorder characterized by cholesterol accumulation, the loss of Purkinje neurons in the cerebellum, hyperphosphorylation of tau and profound neuroinflammation. It is intriguing that this rare inherited disease (caused by mutations in NPC1 or NPC2 genes) shows several key features of a complex Alzheimer&#39;s disease (AD). However, these two neurodegenerative disorders show different regional vulnerabilities; hippocampus is the most affected region in AD and is spared in NPC disease, and the cerebellum is spared in AD but is primarily affected in NPC. In this project we will use the knowledge gained through extensive research on the processing of the ß-amyloid precursor protein (APP) in the most common neurodegenerative disease AD to elucidate molecular mechanism(s) of neurodegeneration in a rare disorder NPC. Based on our recent finding that proteolysis of APP by one of the key AD enzymes ß-secretase (BACE1) is enhanced in NPC, in this project we will elucidate the role of BACE1 in the pathogenesis of NPC and whether BACE1 may represent a novel target for treating/ameliorating NPC disease. We will analyze BACE1-proteolysis and distribution of APP and the two recently identified exclusive BACE1 substrates in hippocampus and cerebellum of NPC1- and wt-mice. Primary hippocampal and cerebellar Purkinje neuronal cultures will be used to dissect the mechanism(s) of the BACE1-mediated effect on pathological features of NPC. Also, we will develop an ex vivo model of NPC disease using hippocampal and cerebellar organotypic brain slices and will monitor whether BACE1-inhibition may prevent/ameliorate any of the NPC pathological features. Lastly, we will genetically deplete BACE1 in NPC1-mice to validate our findings in vivo. These studies may indicate a role of BACE1 in NPC pathogenesis and the potential of targeting BACE1 as an alternative approach for treating this devastating disease.]]></summary_en></project><project>
<id>7442</id><title_hr><![CDATA[Mikotoksini u hrvatskim tradicionalnim mesnim proizvodima: molekularna identifikacija plijesni producenata i procjena izloženosti potrošača]]></title_hr><title_en><![CDATA[Mycotoxins in traditional Croatian meat products: molecular identification of mycotoxin-producing moulds and consumer exposure assessment ]]></title_en><user_id>135</user_id><user_firstLast_name>Jelka Pleadin</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2018-01</proposal_call><code>IP-2018-01-9017</code><acronim><![CDATA[TMPmouldRISK]]></acronim><duration>01.11.2018 - 31.10.2022</duration><status>Završio</status><financ_value>132.712,19 eur</financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Prehrambena tehnologija, Interdisciplinarne biotehničke znanosti, </scie_field_hr><scie_field_en>Food technology, Interdisciplinary biotechnical sciences, </scie_field_en><institution_hr><![CDATA[Hrvatski veterinarski institut]]></institution_hr><institution_en><![CDATA[Croatian Veterinary Institute]]></institution_en><team_members_id>7761, 19402, 23422, 23487, 2782, 4243, 3740, 23478, 3689, 23472, 23475, 23470, </team_members_id><team_members_names><![CDATA[Nada Vahčić, Željko  Jakopović, Tomaz Polak, Brigita Hengl, Mario Mitak, Manuela Zadravec, Nina Kudumija, Tina Lešić, Ana Vulić, Mario Škrivanko, Irena Perković, Maja Kiš, ]]></team_members_names><keywords_hr><![CDATA[mikotoksini, hrvatski tradicionalni mesni proizvodi, molekularna identifikacija, plijesni, procjena izloženosti potrošača]]></keywords_hr><keywords_en><![CDATA[mycotoxins, traditional Croatian meat products, molecular identification, moulds, consumer exposure assessment ]]></keywords_en><summary_hr><![CDATA[Dosadašnja istraživanja o mikotoksinima u tradicionalnim mesnim proizvodima (TMP) uglavnom su usmjerena na okratoksin A (OTA) te aflatoksin B1 (AFB1), dok su spoznaje o pojavnosti citrinina (CIT), sterigmatocistina (STC) i ciklopiazonične kiseline (CPA) općenito nedostatne. Isto tako, nedostaje podataka o vrstama plijesni koje obrastaju površinu TMP i produciraju ove mikotoksine kao sekundarne metabolite u ovisnosti o brojnim čimbenicima utjecaja. U okviru predloženog projekta, u najznačajnijih predstavnika hrvatskih TMP, molekularnim metodama (lančana reakcija polimerazom, PCR) identificirati će se vrste površinskih plijesni i dokazati geni odgovorni za produkciju mikotoksina. Identificirane plijesni dovesti će se u vezu s utvrđenim senzorskim i fizikalno-kemijskim svojstvima TMP te pojavnošću mikotoksina. Koncentracije AFB1, OTA i CIT odrediti će se primjenom tekućinske kromatografije (ultra) visoke djelotvornosti u kombinaciji s fluorescentnom detekcijom (uHPLC-FLD), dok će se za određivanje STC i CPA razviti metode tekućinske kromatografije s tandemskom spektrometrijom masa (LC-MS/MS). Razvoj ovih metoda dati će značajan analitički doprinos u daljnjim istraživanjima pojavnosti STC i CPA u mesnim proizvodima diljem svijeta. Prema našim saznanjima, provedena istraživanja po prvi puta će dati uvid u koncentracije svih mikotoksina značajnih za mesne proizvode, ujedno uzimajući u obzir utjecaj vrste TMP te regionalnih klimatskih uvjeta tijekom dvije proizvodne godine. Temeljem prehrambenih navika stanovništva u Hrvatskoj, provesti će se procjena izloženosti potrošača mikotoksinima kroz konzumaciju ove vrste proizvoda, a rezultati istraživanja služiti će za izradu znanstvenog mišljenja, kao vrijedne podloge nadležnim tijelima u području sigurnosti hrane za uspostavu najvećih dopuštenih količina (NDK) mikotoksina u mesnim proizvodima, te proizvođačima u cilju prevencije kontaminacije TMP.]]></summary_hr><summary_en><![CDATA[Research on mycotoxins in traditional meat products (TMPs) conducted insofar has mostly been focused on ochratoxin A (OTA) and aflatoxin B1 (AFB1), while the knowledge on citrinin (CIT), sterigmatocystin (STC) and cyclopiazonic acid (CPA) prevalence is still insufficient. Data on mould species overgrowing TMP surfaces and producing these mycotoxins as secondary metabolites depending on a number of factors are also scarce. Within the frame of the proposed project, mould species overgrowing the surface of the most prominent Croatian TMPs shall be identified using molecular techniques (Polymerase Chain Reaction, PCR); on top of that, genes responsible for mycotoxin production shall be pinpointed. The identified moulds shall be linked to the established sensory and physicochemical features of TMPs and mycotoxins occurrence. Concentrations of AFB1, OTA and CIT shall be determined using (ultra) high performance liquid chromatography combined with fluorescence detection (uHPLC-FLD). As for the STC & CPA determination, liquid chromatography tandem mass spectrometry (LC-MS/MS) techniques shall be developed, contributing thereby to the potential of analytical tools to be used in further research devoted to the prevalence of these mycotoxins worldwide. To the best of our knowledge, this research shall give the very first insight into the concentrations of each and every mycotoxin of relevance for meat products, taking thereby into account the type of TMPs and the impact of regional climate witnessed during the two production years. Based on the data on dietary habits of Croatian population, TMPs consumption-mediated consumer exposure to these mycotoxins shall be assessed. The results of this research shall serve as the cornerstone for Scientific Opinion drafting and a valuable rationale to be used by food safety authorities in stipulating the Maximum Levels (MLs) of mycotoxins in meat products, as well for producers striving to prevent TMPs contamination.]]></summary_en></project><project>
<id>7443</id><title_hr><![CDATA[Uloga fosfoinozitida u nastanku trombocita]]></title_hr><title_en><![CDATA[]]></title_en><user_id>35</user_id><user_firstLast_name>Antonija Jurak Begonja</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-01</proposal_call><code>DOK-2018-01-7426</code><acronim><![CDATA[MkPI]]></acronim><duration>19.09.2018 - 29.12.2022</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Fakultet biotehnologije i razvoja lijekova]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Biotechnology and Drug Development]]></institution_en><team_members_id>24298</team_members_id><team_members_names><![CDATA[ Doktorand: Ana Bura ]]></team_members_names><keywords_hr><![CDATA[megakariociti, trombociti, trombopoeza, endocitoza, fosfoinozitidi]]></keywords_hr><keywords_en><![CDATA[megakaryocytes, platelets, thrombopoiesis, endocytosis, phosphoinositides]]></keywords_en><summary_hr><![CDATA[Trombociti su neophodni za hemostazu te također posreduju u procesima različitih bolesti uključujući upale, metastaze, aterosklerozu. Liječenje leukemija i drugih malignih oboljenja ili transplantacije organa često dovode do smanjenja broja trombocita, te predstavljaju rizik od krvarenja. Trombociti nastaju iz citoplazme megakariocita (MK) u koštanoj srži u procesu trombopoeze. MK prolaze složen proces sazrijevanja koji vodi ka stvaranju dugih, razgranatih citoplazmatskih struktura – protrombocita. Molekularni mehanizmi koji reguliraju ove citoplazmatske promjene MK-a u velikoj mjeri su nepoznati. Naša preliminarna istraživanja pokazuju da određena vrsta fosfoinozitida (PI), fosfatidilinozitol 3-monofosfat (PI3P) ima glavnu ulogu u formiranju protrombocita u primarnim kulturama MK-a. U stanicama PI3P se nalazi u ranim endosomima i sudjeluje u endosomskom prometu. Naša je hipoteza da membranski promet reguliran PI3P-om u endocitnom putu znatno pridonosi biogenezi trombocita. Predloženi projekt istražit će točnu ulogu PI3P u stvaranju protrombocita. Koristit ćemo genetski napravljene  fluorescentne probe, tehniku koja se temelji na proteinskim domenama fuzioniranim s fluorescentnim proteinom eksprimiranim s retrovirusa, kako bi odredili lokalizaciju u stvarnom vremenu različitih PI u MK-ima i protrombocitima. Istražit ćemo kako interferencija PI3P funkcije utječe na sazrijevanje MK te utvrditi je li defekt ograničen na endosomski odjeljak. U svrhu utvrđivanja mehanizma djelovanja PI3P-a koristit ćemo genetski i farmakološki pristup kako bi ispitali je li progresija ranih u kasne endosome nužna za stvaranje trombocita. Osim toga, identificirat ćemo proteine koji vežu PI3P regulirajući endosomsku dinamiku važnu za stvaranje protrombocita. Ovo će istraživanje doprinijeti našem razumijevanju osnovnih molekularnih procesa trombopoeze koji bi mogli doprinijeti novim terapijskim strategijama u liječenju trombocitopenije.]]></summary_hr><summary_en><![CDATA[Platelets are essential for hemostasis and they also mediate diverse disease processes including inflammation, metastasis, atherosclerosis. Cancer and leukemia treatments or organ transplants often lead to reduced platelet numbers, putting patients at risk of bleedings. Platelets derive from cytoplasm of megakaryocytes (MKs) in the bone marrow in a process called thrombopoiesis. MKs undergo complex maturation process that leads towards extension of long, branched cytoplasmic structures called proplatelets that eventually release platelets. Molecular mechanisms that govern these elaborate cytoplasmic changes of MKs remain largely unknown. Based on primary MKs our preliminary studies show that one type of phosphoinositides (PIs), phosphatidylinositol 3-monophosphate (PI3P) has a major role in proplatelet formation. PI3P is concentrated in early endosomes and is involved in endosomal trafficking. Our hypothesis is that PI3P regulation of membrane traffic in the endocytic pathway contributes significantly to platelet biogenesis. This proposed project will reveal the exact role of PI3P in proplatelet formation. We will use genetically engineered fluorescent probes, a technique based on protein domains fused with fluorescent protein expressed from retroviruses, to define spatial and temporal localization of different PIs in MKs and proplatelets. We will investigate if interference of PI3P function affects MK maturation and examine if defect is confined to endosomal compartment. To determine mechanism of PI3P action we will use genetic and pharmacologic approaches to examine if progression of early to late endosomes is needed for platelet genesis. In addition, we will identify proteins  that act in concert with PI3P to regulate endosomal dynamics important for proplatelet formation. These studies will contribute to our understanding of basic molecular processes underlying thrombopoieses and might lead towards novel therapeutic strategies in treatment of thrombocytopenia.]]></summary_en></project><project>
<id>7444</id><title_hr><![CDATA[Ekologija i karakterizacija dva nova virusa vinove loze]]></title_hr><title_en><![CDATA[Ecology and characterization of two novel viruses infecting grapevine]]></title_en><user_id>21451</user_id><user_firstLast_name>Darko Voncina</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2018-01</proposal_call><code>IP-2018-01-1305</code><acronim><![CDATA[ENVISaGE]]></acronim><duration>01.12.2018 - 30.11.2022</duration><status>Završio</status><financ_value>153.945,19 eur</financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Poljoprivreda, Interdisciplinarne biotehničke znanosti, </scie_field_hr><scie_field_en>Agriculture, Interdisciplinary biotechnical sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Agronomski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Agriculture]]></institution_en><team_members_id>4954, 13509, 24128, 23863, 24209, 11198, 26015, 855437, </team_members_id><team_members_names><![CDATA[Boris Lazarević, Zvjezdana Marković, Maher Al Rwahnih, Pierfederico La Notte, Angelo De Stradis, Darko  Preiner, Martin  Jagunić, Mladen Poletti Kopešić, ]]></team_members_names><keywords_hr><![CDATA[detekcija, distribucija, prijenos, zeljasti domaćini, biološke karakteristike, ozdravljivanje, utjecaj, elektronska mikroskopija]]></keywords_hr><keywords_en><![CDATA[detection,distribution, transmission, herbaceous hosts, biological properties, sanitation, impact, electron microscopy]]></keywords_en><summary_hr><![CDATA[Vinova loza je jedna od najstarijih kultura koja se uzgaja u svim dijelovima svijeta gdje za to  vladaju povoljni klimatski uvjeti. Osim povoljnih uvjeta za uzgoj, Hrvatsku karakterizira značajan broj autohtonih sorata vinove loze, a vinogradarstvo predstavlja važan dio nacionalnog gospodarstva. Do danas je kod loze utvrđeno više od 75 različitih virusa.  Virusne bolesti predstavljaju veliki ekonomski problem u poljoprivrednoj proizvodnji širom svijeta, posebno kod kultura s vegetativnim razmnožavanjem. Njihova kontrola se  uglavnom temelji na suzbijanju poznatih vektora (insekti, grinje, nematode), korištenju bezvirusnog sadnog materijala i konstantnom radu na klonskoj i zdravstvenoj selekciji. Uvođenjem tehnike sekvenciranja nove generacije (NGS) u dijagnostiku biljnih patogena, nekoliko novih virusa potvrđeno je u vinovoj lozi. Dva nova virusa, uvjetno nazvana G-virus vinove loze i badnavirus vinove loze 1, nedavno su primjenom NGS metode pronađeni kod hrvatskih autohtonih sorata. Međutim, biološki podaci o nedavno otkrivenim virusima vrlo su ograničeni ili ne postoje, a sposobnost otkrivanja velikog broja mogućih patogena ograničene je primjenjivosti ako ne postoje istraživanja koja opisuju njihove uloge i kako smanjiti njihov negativan utjecaj na ekonomski značajne kulture. Uzimajući u obzir  dogmu da se svi virusi smatraju patogenima dok se ne dokaže drugačije, cilj projekta je detaljnije istražiti dva nova virusa vinove loze. Projekt će rezultirati robusnim i pouzdanim testovima za detekciju dva virusa, podacima o njihovoj morfologiji i rasprostranjenosti u Hrvatskoj, načinu prijenosa (mehanički, vektori, sjeme, cijepljenje), alternativnim domaćinima, mogućnosti uklanjanja iz zaraženih biljaka i utjecaja na fiziološke procese kod različitih sorata u normalnim i sušnim uvjetima. Projekt će dati korisne podatke o ekonomskoj važnosti novih virusa, potrebi za regulacijom (karantena ili uvoz/ izvoz) zajedno s mogućnostima njihove odgovarajuće kontrole.]]></summary_hr><summary_en><![CDATA[Grapevine is one of the oldest crop cultivated in all parts of the word with appropriate climatic conditions. Beside favorable conditions for grapevine production, Croatia is characterized by significant number of autochthonous cultivars and viticulture is representing important branch of national economy. Up to date over 75 different viruses have been identified from grapevine. Viral diseases are currently a major economic problem in agriculture throughout the world, especially in crops with vegetative propagation. Their management is mainly based on control of known vectors (insects, mites, nematodes), use of virus-free planting material and constant work on clonal and sanitary selection. With implementation of next generation sequencing (NGS) in diagnostic of plant pathogens several novel viruses from grapevine were reported. Two novel viruses, tentatively named grapevine virus G and grapevine badnavirus-1, were recently reported from Croatian autochthonous grapevine varieties using NGS. However, biological information about recently reported viruses is very limited or non-existent, and the ability to detect large number of putative pathogens is of limited applied value if there are no studies describing their respective roles or how to reduce their impact to a crop of economic importance. Challenging the dogma that all viruses are considered pathogens till proved otherwise, aim of the project is detailed investigation or two novel viruses reported from Croatia. Project will resulted in robust detection assays for novel viruses, data about their morphology and distribution in Croatia, modes of spread (mechanical, vectors, seed, grafting), alternative hosts, sanitation and impact on physiological process of different grapevine varieties under normal and dry conditions. Project will generate beneficial data about economic importance of novel viruses, need for regulation (quarantine or import/export) together with options for appropriate management.]]></summary_en></project><project>
<id>7446</id><title_hr><![CDATA[Održiva proizvodnja biokemikalija iz sekundarnih lignoceluloznih sirovina ]]></title_hr><title_en><![CDATA[Sustainable production of biochemicals from waste lignocellulose containing feedstocks]]></title_en><user_id>4332</user_id><user_firstLast_name>Božidar Šantek</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2018-01</proposal_call><code>IP-2018-01-9717</code><acronim><![CDATA[OPB-SLS/SPB-LCF ]]></acronim><duration>01.11.2018 - 31.10.2022</duration><status>Završio</status><financ_value>199.084,21 eur</financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Biotehnologija, </scie_field_hr><scie_field_en>Biotechnology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prehrambeno-biotehnološki fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Food Technology and Biotechnology]]></institution_en><team_members_id>5039, 4544, 4321, 450, 3709, 4912, 6032, 1307, 453, 4324, 5414, 4098, 4102, 4100, 4438, 23620, 23617, 23329, 864820, 4430, 26476, </team_members_id><team_members_names><![CDATA[Vesna  Zechner-Krpan, Draženka Komes, Ivan-Krešimir Svetec, Tonči Rezić, Vlatka Petravić Tominac, Sunčica Beluhan, Mirela Ivančić Šantek, Damir Stanzer, Jasna Mrvčić, Anamarija Štafa, Marina Svetec Miklenić, Antonija Trontel, Mladen Pavlečić, Mario Novak, Aleksandra  Vojvodić Cebin, Nenad Marđetko, Karla Hanousek Čiča, Ana Huđek, Angela Matanović, Arijana Martinić, Danijela Šeremet, ]]></team_members_names><keywords_hr><![CDATA[proizvodnja biokemikalija, lignocelulozne sirovine, integralni bioprocesi, procjena održivosti, procedura za povećanje mjerila]]></keywords_hr><keywords_en><![CDATA[biochemicals production, lignocellulose containing feedstocks, integral bioprocesses, sustainbility evaluation, scale-up procedure]]></keywords_en><summary_hr><![CDATA[Ovaj projekt bavi se razvojem održivih bioprocesa za proizvodnju biokemikalija [mikrobnih lipida (posebno poli-nezasićenih masnih kiselina), L-laktata, 2,3-butandiola i polifenola] iz sekundarnih lignoceluloznih sirovina (npr. ostataka šumarstva i prerade drva, pšenične slame, kukuruzovine i kukuruznih oklasaka, otpadne trave, kore banane i cikle, mahune graška, ljuske luka, ljuske kakaovog zrna i oraha). Predobrade tih sirovina provodit će se u visokotlačnom reaktoru uz primjenu metode koja koristi razrijeđenu kiselinu ili lužinu. U drugom stupnju predobrade, čvrsti ostatak (iz visokotlačnog reaktora) bit će podvrgnut procesu hidrolize pomoću komercijalnih enzimskih preparata ili mikroorganizama s relativno velikom celulitičkom aktivnošću. U ovom istraživanju dobiveni hidrolizati lignoceluloznih sirovina biti će analizirani, korigirat će im se sastav, te će se primijeniti za proizvodnju biokemikalija. Istraživanje proizvodnje biokemikalija bit će fokusirano na provođenje bioprocesa na polučvrstim ili čvrstim supstratima u horizontalnom rotirajućem cijevnom bioreaktoru. Odabrat će se najadekvatniji mikroorganizmi za proizvodnju proučavanih biokemikalija čije će osobine biti poboljšane primjenom metoda genetičkog inženjerstva. Za izdvajanje i pročišćavanje tih biokemikalija bit će razvijeni postupci koji će biti integrirani s procesom njihove proizvodnje da bi se poboljšali ekološki i ekonomski aspekti tih bioprocesa. Održivost proizvodnje proučavanih biokemikalija bit će procjenjena na osnovi LCA. Najefikasnija i održiva konfiguracija proučavanih bioprocesa će se definirati na osnovi LCA rezultata, te će se razviti procedura za povećanje mjerila. Procedura za povećanje mjerila će se bazirati na razvijenom integralnom matematičkom modelu bioprocesa i ostalim kriterijima za povećanje mjerila. Novi integrirani bioprocesi za proizvodnju biokemikalija iz sekundarnih lignoceluloznih sirovina glavni su rezultat ovog projekta.]]></summary_hr><summary_en><![CDATA[This project proposal is dealing with development of sustainable bioprocesses for the biochemicals [microbial lipids (especially polyunsaturated fatty acids), L-lactate, 2,3-butanediol and polyphenols] production from the waste lignocellulose containing feedstocks (e.g. forestry residues, wheat straw, corn stover and cobs, waste grass, banana and beetroot peels, pea pods, onion peels, cocoa bean husks and walnut shells). Pretreatment of these feedstocks will be performed in high pressure reactor combined with the use of dilute acid or alkaline methods. In second stage of pretreatment, the solid residues (from high pressure reactor) will be hydrolyzed be using commercial enzymes mixtures or microorganism with relatively high cellulolytic activity. In this research, obtained hydrolyzates of lignocellulose containing feedstocks will be analyzed, corrected their content and used for biochemicals production. The study of biochemicals production will be focused on the semi-solid or solid state fermentations in the horizontal rotating tubular bioreactor (HRTB). The most suitable microorganisms for these biochemicals production will be identified and improved by genetic methods. Separation and purification procedure for studied biochemicals have to be developed and integrated with their production in order to improve ecological and economical aspects of these bioprocesses. The sustainability of these biochemicals production will be evaluated through the Life Cycle Assessment (LCA). The most efficient and sustainable bioprocess configuration will be defined on the basis of LCA results and consequently scale-up procedure will be developed. The scale-up procedure will be based on the developed integral bioprocess mathematical model and other scale-up criteria. Project outcomes will be new integrated bioprocesses for biochemicals production from waste lignocellulose containing feedstocks.]]></summary_en></project><project>
<id>7448</id><title_hr><![CDATA[Sulfasoli: nova generacija kompleksnih funkcionalnih materijala]]></title_hr><title_en><![CDATA[Sulfosalts: new generation of complex functional materials]]></title_en><user_id>4897</user_id><user_firstLast_name>Denis Sunko</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2018-01</proposal_call><code>IP-2018-01-7828</code><acronim><![CDATA[SulfNewFunMat]]></acronim><duration>01.11.2018 - 31.10.2022</duration><status>Završio</status><financ_value>128.542,04 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, Kemija, </scie_field_hr><scie_field_en>Physics, Chemistry, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>4289, 2708, 3420, 97, 3567, 3247, 23868, </team_members_id><team_members_names><![CDATA[Neven Barišić, Mario Basletić, Ivo Batistić, Ante Bilušić, Predrag Lazić, Petar Popčević, Marko  Kuveždić, ]]></team_members_names><keywords_hr><![CDATA[metalizacija, polarna veza, DFT, sulfidi, kuprati, sinteza, transport]]></keywords_hr><keywords_en><![CDATA[metallization, polar bond, DFT, sulphides, cuprates, synthesis, transport]]></keywords_en><summary_hr><![CDATA[Sulfasoli se uvode kao nova klasa elektronskih materijala koji premoštavaju raspon između dvije poznate klase visokotemperaturnih supravodiča, kuprata i pniktida, te su idealni kandidati za pojavu nove „prijelazne“ fizike. Glavna ideja projekta je eksperimentalno i teorijsko istraživanje veze između orbitalnog sastava aktivnih elektrona i osobina materijala. Ključni novi moment su p orbitale sumpora, koje su analogne kisikovim orbitalama u kupratima ili arsenovim u pniktidima. Budući da su sulfasoli manje ionske od oksida, pokazuju iznenađujuću kristalokemijsku fleksibilnosti i bolju podesivost valencije iona prijelaznih metala. Tako se pojavljuje širok raspon zanimljivih elektronskih, magnetičnih i mehaničkih svojstava. Visoka kompresibilnost sumporovih spojeva olakšava proučavanje utjecaja tlaka na strukturna i elektronska svojstva, u čemu podnositelji imaju posebnog iskustva.Predlažemo proučavanje faznog dijagrama K2(Cu,Fe)4S4 (murunskita), kao posebno izgledne sulfasoli, koji bi prema preliminarnim teorijskim računima moga pokazati niz zanimljivih fizičkih svojstava, uključujući supravodljivost i termoelektriciteta. Paralelno će se proučavati srodni sustavi (npr. BaVS3, anataza, kuprati). Zbog energetskih skala nižih nego u oksidima, čime se pojačava kovalentnost na štetu ioniciteta, te zbogi više mogućih oksidacijskih stanja sumpora, očekujemo da će naši odabrani sulfidi imati i širi raspon i finiju gradaciju ponašanja od oksida prilikom dopiranja, interkalacije, ili pod utjecajem uniaksijalnog ili hidrostatskog tlaka.Osim što je strukturalno analogan kupratima i pniktidima, murunskit nudi priliku dopiranja duž dvije elektronski aktivne osi. Nadamo se da će iskorištavanjem ovih mogućnosti murunskit sam za sebe postati nova paradigmatska klasa funkcionalnih materijala.]]></summary_hr><summary_en><![CDATA[Sulfosalts are introduced as a new class of electronic materials which bridge the gap between the two known classes of high-temperature superconductors, cuprates and pnictides, thus being an ideal candidate for novel “crossover” physics. The main idea is to investigate, experimentally and theoretically, the connection between the orbital content of the active electrons and the material properties. The key player are the sulphur p orbitals, directly analogous to those of oxygen in the cuprates or arsenic in the pnictides. Because sulphides are less ionic than oxides, they show considerable crystallochemical flexibility and superior tunability of the transition metal valences. This gives rise to a variety of interesting electronic, magnetic and mechanical properties. The large compressibility of sulphur compounds facilitates studies of structural and electronic properties of those systems under pressure, which is one domain of the applicants’ expertise.We propose to study the phase diagram of K2(Cu,Fe)4S4 (murunskite) as a particularly promising sulfosalt that could, according to preliminary theoretical calculations, exhibit a variety of exciting physical properties, superconductivity and thermoelectricity included. Related systems will be tackled in parallel (e.g., BaVS3, anatase, cuprates). Because the relevant energy scales are lower than in oxides, promoting covalency at the expense of ionicity, and allowing for several possible oxidation states of sulphur, we expect our sulphides to have a wider range and finer graining of behavior than oxides under doping, intercalation, and uniaxial or hydrostatic pressure.Besides being structurally analogous both to cuprates and to pnictides, murunskite offers the attractive opportunity of two electronically active doping axes. By exploring these opportunities, we hope for murunskite to become a paradigmatic class of modern functional materials by itself.]]></summary_en></project><project>
<id>7451</id><title_hr><![CDATA[Mikrobiom glavate želve (Carreta carreta): uvid u epizoičke i endozoičke zajednice (TurtleBIOME) UIP-05-2017-5635]]></title_hr><title_en><![CDATA[]]></title_en><user_id>4337</user_id><user_firstLast_name>Sunčica Bosak</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-01</proposal_call><code>DOK-2018-01-5777</code><acronim><![CDATA[]]></acronim><duration>23.10.2018 - 23.12.2022</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Biologija, </scie_field_hr><scie_field_en>Biology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>25309</team_members_id><team_members_names><![CDATA[ Doktorand: Klara Filek ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>7455</id><title_hr><![CDATA[Višekromoforne probe za prepoznavanje pojedinih struktura DNA, RNA i proteina]]></title_hr><title_en><![CDATA[Multichromophore probes for recognition of particular DNA, RNA and protein structures]]></title_en><user_id>480</user_id><user_firstLast_name>Ivo Piantanida</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2018-01</proposal_call><code>IP-2018-01-5475</code><acronim><![CDATA[BioMultiChromoProbes]]></acronim><duration>16.11.2018 - 15.11.2022</duration><status>Završio</status><financ_value>131.528,30 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, </scie_field_hr><scie_field_en>Chemistry, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>1232, 2953, 444, 3684, 23618, 26666, 865429, </team_members_id><team_members_names><![CDATA[Ivo Crnolatac, Lidija-Marija Tumir, Vilko Smrečki, Dijana Saftić, Marija Matković, Ivona Krošl, Marta Košćak Košćak, ]]></team_members_names><keywords_hr><![CDATA[DNA, RNA, protein, fluorescencija, supramolekulsko prepoznavanje, bioaktivnost]]></keywords_hr><keywords_en><![CDATA[DNA, RNA, protein, fluorescence, supramolecular recognition, bioactivity]]></keywords_en><summary_hr><![CDATA[Molekularno prepoznavanje nukleinskih kiselina i proteina je od temeljne važnosti za život. Male molekule koje selektivno vežu specifične biomakromolekule stoga su vrlo zanimljive ne samo za razumijevanje takvih procesa već i za potencijalne medicinske primjene, kao lijekovi ili obilježavači za biooslikavanje i analitičke svrhe. U posljednjih 5 godina razvili smo u suradnji s našim partnerima niz novih fluorescentnih aminokiselina i oligopeptida koji su prepoznavali različite DNA ili RNA strukture. Također smo pokazali da se ne-kovalentna agregacija kromofora može koristiti za prepoznavanje DNA / RNA. Nedavno smo razvili inhibitore fluorescentnih enzima i nove mitohondrijske specifične fluorescentne markere. U ovom prijedlogu želimo koristiti veliku biblioteku fluorescentnih aminokiselina razvijenih u prethodnom HrZZ projektu (i pripremiti nove poboljšane), kao i naša znanja o agregaciji boja, te dizajnirati i pripremiti multikromoforne peptide s različito kombiniranim kromoforima (npr. FRET parovi) i DNA / RNA / proteinski ciljanim supstituentima. Takvi peptidni sustavi bi poslužili kao višenamjenski obilježavači za simultano obilježavanje (različitim spektrometrijskim odgovorima) nekoliko različitih sekundarnih struktura (npr. raznih ds- ili ss-DNA / RNA sekvenci, proteina). Alternativno, peptidi će biti dizajnirani za visoko selektivnu interakciju s određenim biološkim ciljem (npr. određeni ds- ili ss-DNA/RNA slijed, DPP III enzim ili amiloid-fibrilacijski peptidni slijed). Interakcija s DNA / RNA / proteinima proučavat će se UV / Vis, fluorescencijom, CD / LD spektroskopijom i DSC / ITC mikrokalorimetrijom, MS, NMR, CLSM.Prijedlog je u skladu s ciljevima HrZZ-a: a) suradnja s međunarodno dobro prepoznatim inozemnim znanstvenicima, b) osposobljavanje mladih istraživača u međunarodnom istraživačkom okruženju i c) očekivani rezultati imaju potencijal komercijalizacije kao nove biokemijski obilježavači / ili lijekovi. Troškovi projekta su 994.000,00 kn za 4 godine.]]></summary_hr><summary_en><![CDATA[Molecular recognition of nucleic acids and proteins is of fundamental importance for life. Small molecules selectively targeting specific biomacromolecules are therefore highly interesting not only for understanding of such processes but also for potential medicinal applications, as drugs or probes for bioimaging and analytical purposes. In the last 5 years we developed in collaboration with our partners a series of novel fluorescent amino acids and oligopeptides, which recognised various types of DNA or RNA structures. Also, we showed that non-covalent aggregation of chromophores could be used for DNA/RNA recognition. Very recently we developed fluorescent enzyme inhibitors and novel mitochondria-specific fluorescent markers. In this proposal we want to use large library of fluorophore-amino acids developed in previous CSF project (and prepare new improved ones), as well as our knowledge on dye aggregation, to design and build multichromophore peptides, with variously combined chromophores (e.g. in FRET pairs) and DNA/RNA/protein targeting substituents. Such peptides would serve as multi-purpose probes for the simultaneous sensing (by different spectrometric responses) of several different biomacromolecule secondary structures (e.g. various ds- or ss- DNA/RNA sequences, proteins). Alternatively, peptides will be designed for highly selective interaction with particular bio-target (e.g. particular ds- or ss- DNA, RNA, DPP III enzyme or amyloid-fibrillation peptide sequence). The interaction with DNA/RNA/proteins will be studied by UV/Vis, fluorescence, CD/LD spectroscopy and DSC/ITC microcalorimetry, MS, NMR, CLSM. Proposal addresses the most important CSF goals: a) collaboration with well-established international scientists, b) training of young researchers within the international research environment and c) the expected results have commercialisation potential as novel biochemical probes and/or drugs. Project costs are 994,000.00 HRK for 4 years.]]></summary_en></project><project>
<id>7457</id><title_hr><![CDATA[Izračunljive strukture, odlučivost i složenost]]></title_hr><title_en><![CDATA[Computable structures, decidability and complexity]]></title_en><user_id>19935</user_id><user_firstLast_name>Zvonko Iljazović</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2018-01</proposal_call><code>IP-2018-01-7459</code><acronim><![CDATA[CompStruct]]></acronim><duration>01.10.2018 - 30.09.2022</duration><status>Završio</status><financ_value>88.127,94 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Matematika, </scie_field_hr><scie_field_en>Mathematics, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>23802, 21430, 23804, 21409, 23807, 19927, 23844, 23890, 19210, 24114, 25399, </team_members_id><team_members_names><![CDATA[Vedran Čačić, Luka Mikec, Mladen Vuković, Tin Perkov, Konrad Burnik, Lucija Validžić, Marko Horvat, Sebastijan Horvat, Bojan Pažek, Domagoj Vrgoč, Matea Kalinić, ]]></team_members_names><keywords_hr><![CDATA[izračunljiva analiza, izračunljiva topologija, izračunljivost skupa, odlučivost logika, složenost logika, ]]></keywords_hr><keywords_en><![CDATA[computable analysis, computable topology, computability of a set, decidability of logics, complexity of logics]]></keywords_en><summary_hr><![CDATA[Predloženi projekt trebao bi koordinirati i podržavati aktivnosti hrvatske grupe koja se bavi istraživanjima u matematičkoj logici i teorijskom računarstvu. Očekivane teme istraživanja su izračunljivost u analizi i topologiji te odlučivost i složenost raznih logika.Jedan od glavnih ciljeva ovog projekta je istraživanje nekoliko aspekata izračunljive analize. Posebno, planira se istraživanje uvjeta pod kojima je poluizračunljiv skup u izračunljivom metričkom ili topološkom prostoru izračunljiv. Poznato je da topologija ima važnu ulogu u opisu takvih uvjeta. Istraživanja planirana ovim projektom trebala bi doprinijeti daljnjem razumijevanju odnosa izračunljivosti i topologije. Nadalje, u ovom projektu će biti istražena razna svojstva struktura izračunljivosti na metričkim prostorima kao i odnos između separabilnih i maksimalnih struktura izračunljivosti. Također je u planu istražiti, s gledišta izračunljivosti, neka svojstva metričkih prostora na kojima je zadana određena geometrijska struktura. Logike interpetabilnosti su proširenja logike dokazivosti GL (Gödel-Löb). Glavno otvoreno pitanje u području je odrediti aksiomatizaciju logike IL(All), tj. logike interpretabilnosti koja je u presjeku svih sistema. Kao pokušaj odgovora na to glavno pitanje definirane su razna proširenja osnovnog sistema IL. U predloženom projektu trebala bi se istražiti potpunost nekih proširenja u odnosnu na generaliziranu Veltmanovu semantiku. Zatim, namjera nam je proučiti odlučivost i složenost, te implementirati algoritme. Posebno će se razmatrati složenost nekih deskriptivnih logika koje su povezane s nadogradnjama propozicijske dinamičke logike, a imaju primjenu u bazama podataka.]]></summary_hr><summary_en><![CDATA[The proposed project is intended to help coordinate and support the activities of the Croatian group which carries out research in mathematical logic and theoretical computer science. The envisioned topics of research are computability in analysis and topology and the decidability and complexity of various logics.One of the main objectives of this project is the investigation of several aspects of computable analysis. In particular, it is planned to examine conditions under which a semicomputable set in a computable metric or topological space is computable. It is known that topology plays an important role in the description of such conditions. The investigations planned in this project should contribute to the further understanding of the relationship between computability and topology. Furthermore, in this project will be investigated various properties of computability structures on metric spaces as well as the relationship between separable and maximal computability structures. It is also planned to examine, from the computability viewpoint, some properties of metric spaces on which certain geometric structure is given.Interpretability logics are extensions of provability logic GL (Gödel-Löb). The main open question in the area is to determine the axiomatization of the logic IL(All), i.e. the interpretability logic that is in the intersection of all the systems. In an attempt to answer this famous question, various extensions of the basic system IL were defined. The completeness of some extensions w.r.t. generalized Veltman semantics should be studied in this project. Further, we purpose to study decidability and complexity, and then we would like to consider implementation of algorithms for deciding provability. Particular consideration will be given to the complexity of some descriptive logics that are associated with the upgrades of the propositional dynamic logic and have application in databases.]]></summary_en></project><project>
<id>7458</id><title_hr><![CDATA[Fizika mnogočestičnih sustava - iskorištavanje svijeta kompleksnosti]]></title_hr><title_en><![CDATA[]]></title_en><user_id>4336</user_id><user_firstLast_name>Osor  Slaven Barišić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-01</proposal_call><code>DOK-2018-01-9860</code><acronim><![CDATA[COMPLEX_ORBIS]]></acronim><duration>20.09.2018 - 19.09.2022</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, </scie_field_hr><scie_field_en>Physics, </scie_field_en><institution_hr><![CDATA[Institut za fiziku]]></institution_hr><institution_en><![CDATA[Institute of Physics in Zagreb]]></institution_en><team_members_id>25108</team_members_id><team_members_names><![CDATA[ Doktorand: Juraj Krsnik ]]></team_members_names><keywords_hr><![CDATA[jaka međudjelovanja, nered, neravnotežna dinamika, kompleksni sustavi, izranjajuće pojave]]></keywords_hr><keywords_en><![CDATA[strong interactions, disorder, nonequlibrium dynamics, complex systems, emerging phenomena]]></keywords_en><summary_hr><![CDATA[Kompleksni sustavi karakterizirani su izranjajućim pojavama koje se u hijerarhiji skala pojavljuju vrlo daleko od onih skala koje karakteriziraju međuodnose između pojedinačnih sastavnica tih sustava. Zato takve pojave, vrlo različitih uzroka, konstantno privlače pažnju znanstvene zajednice. Bez obzira na inherentnu raznolikost, različite teme vezane za fiziku kompleksnih sustava dijele neke zajedničke koncepte i principe. Razumijevanje takvog fizikalnog bogatstva zahtijeva razvoj integrativnog teorijskog pristupa, sposobnog  tretirati probleme istovremeno preko različitih polja istraživanja. Osnovna ideja ovoga projekta je ostvarivanje široke strategije istraživanja, birajući probleme koji su izrazito aktualni unutar međunarodnih istraživanja, uz istovremeno održavanje bliske veze s eksperimentalnim rezultatima.Projekt se bavi izranjajućim pojavama u mnogočestičnim sustavima karakteriziranim jakim međudjelovanjem, neredom i/ili izvanravnotežnim stanjem. Predmeti predloženog istraživanja kreću se od specifičnih materijala od posebnog interesa u polju kondenzirane materije, do bioloških sustava, čije se funkcije u prirodnom okruženju u pravilu ostvaruju u izvanravnotežnim stanjima. Projekt je organiziran u tri radna paketa (WP), pri čemu se svaki od njih usredotočuje na jednu od klasa mnogočestičnih sustava u kojima se opažaju izranjajuće pojave. To su sustavi s jakim međudjelovanja, sustavi s neredom i sustavi izvan ravnoteže. Svaki WP je organiziran je u različite zadaće, koje iako su specifične za određeni WP dijele ujedno i značajan stupanj komplementarnosti, osiguravajući koherentnost i međupovezanost između WP-ova.Osim specifičnih znanstvenih doprinosa, namjera projekta je omogućiti i značajnu konsolidaciju teorijskih istraživanja na Institutu za fiziku, uključujući poboljšano okruženje za mlade istraživače. Podrška HrZZ-a projektu je stoga od ključne važnosti za održanje međunarodne kompetitivnosti članova tima, kao i za otvaranje novih perspektiva. ]]></summary_hr><summary_en><![CDATA[Complex systems are characterized by phenomena emerging in the hierarchy of scales far from those describing the numerous individual components. Such phenomena, which have a variety of origins, have repeatedly attracted the attention of the scientific community. Irrespective of the inherent diversity, some common concepts and principles are shared across different topics. Uncovering and understanding this richness requires the development of an integrative theoretical approach, capable of dealing with many-body problems across different fields. In this light, the main purpose of the present project is to enforce such a broad strategy by choosing problems that are highly relevant in current international research endeavors, while simultaneously maintaining a close connection with experimental results.The project addresses phenomena that emerge in systems characterized by strong interactions, disorder and/or the absence of equilibrium. The objects of the proposed research range from specific materials, the investigation of which is on the forefront of condensed matter research, to biological systems, functioning in their natural environment as physical systems far from equilibrium. The project is organized into work packages (WPs), each of which focuses on one important aspect of many-body systems exhibiting emergent phenomena. These are strong interactions, disorder and out-of-equilibrium dynamics. Each WP is organized around a series of different tasks, which, while WP-specific, share a significant degree of complementarity, ensuring coherence and interconnectedness across the WPs. Besides specific scientific contributions, the project aims to provide a significant consolidation of theoretical investigations at the Institute of Physics, including an improved environment for young researchers. The HrZZ’s support of the project is therefore of crucial importance for maintaining the international competitiveness of team members and for future perspectives.]]></summary_en></project><project>
<id>7459</id><title_hr><![CDATA[Platforma za satelitsko mjerenje elektromagnetskog zračenja]]></title_hr><title_en><![CDATA[Satellite-based measurement of electromagnetic radiation]]></title_en><user_id>7148</user_id><user_firstLast_name>Dubravko Babic</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2018-01</proposal_call><code>IP-2018-01-2504</code><acronim><![CDATA[CROSPERITY]]></acronim><duration>22.10.2018 - 21.10.2022</duration><status>Prekinut</status><financ_value>193.158,40 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Elektrotehnika, Računarstvo, Strojarstvo, Zrakoplovstvo, raketna i svemirska tehnika, Temeljne tehničke znanosti, Interdisciplinarne tehničke znanosti, </scie_field_hr><scie_field_en>Electrical engineering, Computer sciences, Mechnical engineering, Aerospace, missile and space engineering, Basic engineering sciences, Interdisciplinary technological sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id>23858, 6686, 6955, 20069, 6893, 3652, 24438, 17790, 26560, 858311, </team_members_id><team_members_names><![CDATA[Josip Vuković, Zvonimir Šipuš, Tomislav Suligoj, Josip Lončar, Marko Bosiljevac, Ana Babic, Stefan Cikota, Jurica Jurec, Sonja Grgić, Tomislav Kos, ]]></team_members_names><keywords_hr><![CDATA[piko-sateliti, cubesat, geomagnetsko polje, svjetlosno zagađenje, promatranje Zemlje]]></keywords_hr><keywords_en><![CDATA[pico-satellite, cubesat, geomagnetic field, light pollution, Earth observation]]></keywords_en><summary_hr><![CDATA[Plan ovog projektnog prijedloga je razvoj platforme za satelitsko mjerenje elektromagnetskih emisija sa zemlje i iz svemira. Razvijena platforma će biti demonstrirana implementacijom (i) novog ultraljubičastog fotodetektora na temelju elementarnog bora (engl. pure B) u svrhu demonstracije robusnosti i primjenjivosti ovog tipa detektora na svemirske uvjete, (ii) sustava za spektralno razlučenje svjetla u svrhu identifikacije svjetlosnih izvora u svrhu praćenja razvoja svjetlosnog zagađenja sa Zemlje, tj. zamjene električnih žarulja i fluorescentnog osvjetljenja svjetlećim diodama, i (iii)  sustavom za mjerenje geomagnetskog polja u svrhu identifikacije fenomena koji utječu na navigaciju i praćenje satelita. Visina sa koje će se opservacije voditi je oko 600 km, a područje mjerenja bit će globalno.  U sklopu ovog projekta, razvit će se piko-satelit volumena 1 litre i težine 1 kg (CubeSat) koji će biti prilagođen za navedenu mjernu platformu.]]></summary_hr><summary_en><![CDATA[The purpose of this project is the development of a characterization platform for the measurement of electromagnetic emissions from Earth and space. The developed platform shall be demonstrated using (i) a novel ultraviolet photodetector based on pure Boron with the aim to demonstrate the robustness the technology and its suitability for space applications, (ii) a system for spectral resolving of light emitted from the earth to monitor light pollution and the global installation of light-emitting diodes in public places, and (iii)  a system  for monitoring of geomagnetic field which influences the navigation and tracking of satellites. The elevation from which these observations will be made is around 600 km above earth and the measurements will be global (entire earth).  This project plans to develop a pico-satellite with volume 1 liter and 1 kg weight, also known as the CubeSat, that will be customized to perform these functions. ]]></summary_en></project><project>
<id>7461</id><title_hr><![CDATA[Fizika teraskale na LHC-u i u svemiru]]></title_hr><title_en><![CDATA[]]></title_en><user_id>19131</user_id><user_firstLast_name>Oleg Antipin</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-01</proposal_call><code>DOK-2018-01-6503</code><acronim><![CDATA[TsPhLC]]></acronim><duration>01.11.2018 - 30.10.2022</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, </scie_field_hr><scie_field_en>Physics, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>25341</team_members_id><team_members_names><![CDATA[ Doktorand: Jahmall Matteo Bersini ]]></team_members_names><keywords_hr><![CDATA[neutrinske mase, asimptotskih sigurnih teorija, LHC, Standardnog modela,kosmologija]]></keywords_hr><keywords_en><![CDATA[neutrino mass, asymptotically safe theories, LHC, Standard Model, cosmology]]></keywords_en><summary_hr><![CDATA[Europska zajednica je uložila mnogo u razvoj LHC (Velikog hadronskog sudarača čestica) da bi se rješili neki osnovni problemi u fizici visokih energija. LHC Run-2 period koji upravo počinje bi se mogao pokazati kao najuzbudljivije vrijeme u fizicičestica u 21. stoljeću jer postoje naznake za postojanje novih čestica iz ranijih podataka s LHC-a. Ovaj prijedlog projekta će doprinjeti rješavanju fundamentalnih problema unutar fizike visokih energija u svjetlu novih LHC podataka. Cilj ovog projektnog prijedloga je da se dotaknu problemi proširenjem Standardnog modela (SM) jakih, slabih i elektromagnetskih interakcija koje su trenutno prihvačeni teorijski okvir za opisivanje fundamentalnih interakcija elementarnih čestica.Glavni kriterij za uspjeh je dovoljno poznavanje novih eksperimentalnih podataka od strane jakog teorijskoj tima vodećih svjetskih znanstvenika koji rade na povezivanjuizmeđu računa na superračunalnim rešetkama, teorijskih metoda teorije polja, fizike izvan SM i kozmologije. Zajedno sa svojim timom, doprinjet ću različitim relevantnim tehnikama isposobnošću da generiram svoja vlastita istraživanja što je dokazano mojim trenutnim postignutim znanstvenim rezultatima u postojećim suradnjama širom svijeta. Projekt ima četiri faze: 1. Prvo ćemo istražiti novu paradigmu asimptotske sigurnosti proširenja SM s glavnim ciljem formuliranja novih predviđanja za LHC Run-2. 2. S tim novim predviđanjima, cilj nam je proučavati temeljni problem masaneutrina. 3. U ovoj fazi, planiramo obaviti fenomenološke analize tih novih teorija koje vode do točnih predviđanja na ubrzivačima čestica. 4. Konačno, cilj nam je istraživati kozmološke posljedice tih novih modela s težištem naproučavanje tamne materije i bariogeneze.]]></summary_hr><summary_en><![CDATA[The European Community has invested heavily in the Large Hadron Collider (LHC) to solve fundamental problems within high energy physics. The LHC Run-2 period that begins now may prove to be the most exciting time for particle physics in 21th century as there are indications for existence of the new particles from the earlier LHC data. This proposal will contribute to solutions of fundamental problems within high energy physics in light of the new LHC data. The aim of this proposal is to address these problems by extending the Standard Model (SM) of strong, weak and electromagnetic interactions which is the currently accepted theoretical framework to describe interactions of fundamental particles. This is interesting because existing unsolved fundamental problems require new, beyond SM physics.The main criteria for success is a thorough understanding of the new experimental data by the strong theoretical team of the world’s leading researchers working at the interface between lattice supercomputing, field theoretical methods, beyond SM physics and cosmology.Together with my team, I will contribute with a variety of relevant techniques and ability to generate my own research proven by scientific results I currently achieved with existing collaborations worldwide.The project has four phases:1. First I will explore the new paradigm of the asymptotically safe extensions of the SM with the main goal to formulate new predictions for the LHC Run-2.2. With these new predictions, I aim to study the fundamental problem of neutrino mass.3. In this phase, I plan to perform phenomenological analysis of these new theories leading to accurate predictions for colliders.4. Finally, I aim to investigate cosmological implications of these new models with main focus on dark matter and baryogenesis.]]></summary_en></project><project>
<id>7464</id><title_hr><![CDATA[Razumijevanje, praćenje i analiziranje transparentnosti proračuna lokalnih jedinica: Primjer Hrvatske i Slovenije - Indeks otvorenosti lokalnih proračuna]]></title_hr><title_en><![CDATA[]]></title_en><user_id>13372</user_id><user_firstLast_name>Katarina Ott</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-01</proposal_call><code>DOK-2018-01-8937</code><acronim><![CDATA[OLBI]]></acronim><duration>01.11.2018 - 15.12.2023</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Ekonomija, </scie_field_hr><scie_field_en>Economy, </scie_field_en><institution_hr><![CDATA[Institut za javne financije]]></institution_hr><institution_en><![CDATA[Institute of Public Finance]]></institution_en><team_members_id>25362</team_members_id><team_members_names><![CDATA[ Doktorand: Simona Prijaković ]]></team_members_names><keywords_hr><![CDATA[Local government, budget transparency, Open local budget index, Croatia, Slovenia]]></keywords_hr><keywords_en><![CDATA[lokalne jedinice, transparetnost proračuna, Indeks otvorenosti lokalnih proračuna, Hrvatska, Slovenija]]></keywords_en><summary_hr><![CDATA[Transparentnost proračuna lokalnih jedinica (TPLJ) od iznimne je važnosti budući da odluke lokalnih vlasti o trošenju javnih sredstava utječu na svakog građanina.  TPLJ označava u kojoj mjeri i koliko jednostavno građani mogu pristupati informacijama o prihodima i rashodima lokalnih proračuna. Transparentnost proračuna prvi je korak prema demokratizaciji proračunskog procesa i uključivanju građana u oblikovanje politika  i raspodjelu sredstava. Netransparentan proračun ne može se valjano analizirati, njegova se provedba ne može u potpunosti pratiti, niti se mogu vrednovati njegovi ishodi. Unatoč važnosti TPLJ-a, rijetka su istraživanja o njenim mjerenjima, uzrocima i posljedicama. Naš cilj je popuniti tu prazninu u literaturi istražujući: TPLJ u Hrvatskoj i Sloveniji, način na koji se ona mijenja tijekom vremena i razloge zbog kojih su neki lokalni proračuni transparentniji od drugih. Također ćemo nastojati odgovoriti na pitanja utječe li TPLJ na proračunske ishode u izbornim godinama, djeluje li na izborne rezultate i utječu li promjene TPLJ-a tijekom vremena na preferencije političara na vlasti i glasača u vezi s proračunskim ishodima. Oslanjajući se na postojeću literaturu i naše prijašnje radove, cilj nam je postaviti temelj za buduće istraživanje TPLJ-a, čiji će rezultat biti Indeks otvorenosti lokalnih proračuna (IOLP). Najprije ćemo uskladiti i prilagoditi već postojeću hrvatsku metodologiju (Ott, Bronić i Petrušić, 2013.; 2014.), kako bi se  mogla kontinuirano i na isti način primjenjivati na godišnjoj razini u Hrvatskoj i Sloveniji. Budući da će ovo  biti prvi put da se empirijski mjeri i prati TPLJ za prilično dugo razdoblje u dvije zemlje i budući da osim našeg rada (Ott, Bronić i Petrušić, 2013, 2014) nismo uspjeli naći niti jedan drugi rad o uzrocima i posljedicama TPLJ, naš kontinuirani projekt  će predstavljati jedinstven doprinos literaturi. Omogućit ćemo i donošenje boljih politika te veće sudjelovanje građana u odlučivanju o lokalnim proračunima. ]]></summary_hr><summary_en><![CDATA[Local government budget transparency (LBT) is of extreme importance as local authorities’ decisions upon spending public money have an impact on each and every citizen. LBT refers to how easily and to what extent citizens can access information on local government revenues and expenditures. Transparent budgets are a first step toward democratizing the budget process and giving citizens a say in policy formulation and resource allocation. A non-transparent budget cannot be properly analysed, its implementation cannot be thoroughly monitored nor can its outcomes be evaluated. Despite the importance of LBT, research into its measures, causes and consequences is thin. Our aim is to fill this literature gap and investigate: LBT in Croatia and Slovenia, how it changes over time and why some local budgets are more transparent than others. We will also try to answer: whether LBT affects budget outcomes in election years; whether it affects election outcomes and whether its changes over time influence incumbents&#39; and voters’ preferences regarding budget outcomes. Building upon the existing literature and our previous works, the aim is to construct the basis for future research into LBT, resulting in an open local budget index (OLBI). We will first harmonize and adapt the already existing Croatian methodology (Ott, Bronić and Petrušić, 2013; 2014) so that it can be further continually, annually applied in the same way in Croatia and Slovenia. Since this will be the first time that LBT will be empirically measured and monitored for a fairly long period of time in two countries, and since except for our own work (Ott, Bronić and Petrušić, 2013; 2014) we could find no other papers dealing with the causes and consequences of LBT, our continuous research will represent a unique contribution to the existing literature. Our results will also enable better policy-making and greater citizens’ participation in local budget deliberations.  ]]></summary_en></project><project>
<id>7468</id><title_hr><![CDATA[Predplanirana i reaktivna agilnost; razvoj i validacija specifičnih metoda mjerenja, utvrđivanje faktora utjecaja i učinkovitost transformacijskih postupaka]]></title_hr><title_en><![CDATA[Change of direction speed and reactive agility; development of the specific measurement tools, identification of predictors, and evaluation of training effects]]></title_en><user_id>147</user_id><user_firstLast_name>Damir Sekulić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2018-01</proposal_call><code>IP-2018-01-8330</code><acronim><![CDATA[RAGCODS]]></acronim><duration>01.10.2018 - 30.09.2022</duration><status>Završio</status><financ_value>74.338,36 eur</financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Kineziologija, </scie_field_hr><scie_field_en>Kinesiology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Splitu, Kineziološki fakultet]]></institution_hr><institution_en><![CDATA[University of Split, Faculty of Kinesiology]]></institution_en><team_members_id>261, 175, 433, 149, 23813, 3198, 23926, 23986, 27180, 856001, </team_members_id><team_members_names><![CDATA[Mia Perić, Miodrag Spasić, Ognjen Uljević, Nataša  Zenić Sekulić, Ante Krolo, Dinko  Pivalica, Dean Kontić, Aleksandar Selmanović, Barbara Gilić, Toni Modrić, ]]></team_members_names><keywords_hr><![CDATA[testovi, prediktori, povezanost, utjecaj, agilnost otvorene vještine, agilnost zatvorene vještine]]></keywords_hr><keywords_en><![CDATA[tests, predictors, associations, influence, open skill agility, closed skill agility]]></keywords_en><summary_hr><![CDATA[Poznata je važnost agilnosti u sportu, ali je u skorije vrijeme prepoznata njena važnost i izvan natjecateljskog sporta. Utvrđeno je postojanje dva manifestacijska oblika agilnosti: pred-planirane agilnosti (CODS) i reaktivne agilnosti (RAG). Ciljevi projekta su: (i) razviti testove za mjerenje RAG i CODS, (ii) utvrditi faktore utjecaja na RAG i CODS, (iii) provjeriti učinkovitost transformacijskih programa (treninga) u razvoju RAG i CODS; za sportaše i kliničku populaciju. Uzorak ispitanika činiti će sportaši i klinička populacija (svi stariji od 18 godina). Skupinu sportaša činiti će podskupine: rukometaši (n = 60; 50% žena), košarkaši (n = 60; 50% žena), vaterpolisti (n = 60; 50% žena) i igrači fustala (n = 60; 50% žena). Kliničku populaciju činiti će osobe starije od 50 godina koje će se nalaziti na postoperativnom tretmanu nakon operativnog zahvata zamjena zgloba ili artroskopske operacije koljena (n=100; 50% žena). Zavisne varijable biti će novokonstruirani testovi RAG i CODS. Nezavisne varijable biti će antropometrijske mjere i mjere sastava tijela (za sve skupine), mjere brzine, sile, eksplozivne snage i reaktivne snage (za sportaše). Najprije će se razviti i validirati testovi RAG i CODS temeljeni na bežičnim tehnologijama. Potom će se utvrditi povezanost nezavisnih i zavisnih varijabli. Konačno, provjeriti će se efikasnost specifičnih treninga u razvoju RAG i CODS. Metode obrade rezultata uključivati će procjenu metrijskih karakteristika testova, univarijatne i multivarijatne analize povezanosti nezavisnih i zavisnih varijabli, te analize za procjenu učinkovitosti treninga. Radit će se o jednom od prvih istraživanja u svijetu u kojem će se razviti testovi za mjerenje RAG i CODS u različitim sportovima, koje će sistematski istražiti problem RAG i CODS kod analizirane kliničke populacije, te koje će istražiti učinkovitost treninga RAG i CODS. Projekt će imati izravnu primjenu u sportskom treningu i postoperativnoj rehabilitacijskoj praksi.]]></summary_hr><summary_en><![CDATA[The importance of agility in sport is well known, and since recently the significance of this quality is recognized in non-athletic population. Two facets of agility are recognized, differentiating reactive agility (RAG), and change of direction speed (CODS). The aims of this project are: (i) to develop RAG and CODS tests, (ii) to identify predictors of RAG and CODS, (iii) to define efficacy of training aimed at development of RAG and CODS; in athletic- and non-athletic (clinical) participants. The sample will comprise athletes, and clinical sample. The athletes will be involved in handball (n = 60; 50% females), basketball (n = 60; 50% females), water polo (n = 60; 50% females), and futsal (n = 60; 50% females), Clinical sample will comprise 100 participants (50% females, > 50 years) patients at postoperative treatment after joint replacement or arthroscopic knee surgery. The developed tests of RAG and CODS will be observed as dependent variables (DV). The independent (IV) variables will comprise anthropometric/body composition indices (for all participants), sprinting-, power-, force-, and reactive-strength-capacites (for athletes). First, tests of RAG and CODS will be evaluated for reliability and validity. Next, relationships between IV and DV will be established. Finally, the efficacy of the training aimed at improvement of RAG and CODS will be evaluated. Statistics will include analyses aimed at evaluation of (i) reliability and validity of tests, (ii) relationships among variables, and (iii) evaluation of training effects. This investigation will be one of the first which will systematically develop and validate RAG and CODS tests in different sports and clinical population, and probably the first one where the problem of development of RAG and CODS will be systematically investigated. The findings will have direct implications in sports training, as well as in postoperative rehabilitation of an investigated clinical sample.  ]]></summary_en></project><project>
<id>7469</id><title_hr><![CDATA[Prevencija hipoglikemije u trudnica s dijabetesom tipa 1]]></title_hr><title_en><![CDATA[Prevention of hypoglycemia in pregnant women with diabetes type 1]]></title_en><user_id>12342</user_id><user_firstLast_name>Marina Ivanisevic</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2018-01</proposal_call><code>IP-2018-01-1284</code><acronim><![CDATA[PRE-HYPO]]></acronim><duration>01.02.2019 - 31.01.2023</duration><status>Završio</status><financ_value>124.626,72 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Kliničke medicinske znanosti, </scie_field_hr><scie_field_en>Clinical sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb School of Medicine]]></institution_en><team_members_id>12464, 12695, 12701, 12704, 23407, 23562, 23700, 7272, 12770, 12799, 6359, 12803, 26625, </team_members_id><team_members_names><![CDATA[Josip Đelmiš, Slavko Orešković, Josip Juras, Mislav Herman, Ksenija Tuškan, Mirta Starčević, Nada Sindičić Dessardo, Darko Marčinko, Lea Smirčić Duvnjak, Sandra Vučković-Rebrina, Ivana Pavlić-Renar, Vito Starčević, Matea Vukušić Mijačika, ]]></team_members_names><keywords_hr><![CDATA[dijabetes tipa 1, hipoglikemija, trudnoća, kardiovaskularna autonomna neuropatija, kognitivna funkcija, telomere]]></keywords_hr><keywords_en><![CDATA[diabetes type 1, hypoglycemia, pregnancy, cardiovascular autonomic neuropathy, cognitive function, telomere]]></keywords_en><summary_hr><![CDATA[Dijabetes tipa 1 (T1DM) u trudnoći donosi brojne probleme i za majku i za dijete. Ako se želi postići dobar ishod trudnoće, odnosno rađanje zdravoga djeteta, potreban je intenzivni pristup u postizanju normoglikemije prije začeća i tijekom trudnoće. Sa željom za što bolju kontrolu glikemije povisuje se rizik od hipoglikemije, s mogućim nepovoljnim komplikacijama trudnice/babinjače, uključujući komu, konvulzije i smrt. Cilj je prijedloga istraživanja prevencija, odnosno smanjenje pojavnosti hipoglikemije kod trudnice/babinjače s T1DM-om. Specifični ciljevi uključuju: a Izrada smjernica za sprječavanje nastanka hipoglikemije u trudnica s T1DM om na temelju testiranja potencijala biomarkera kao što je C-peptid, pouzdanog pretkazatelja teške hipoglikemije; b) Utvrđivanje utjecaja hipoglikemije na kardiovaskularnu neuropatiju; c) Utvrđivanje utjecaja hipoglikemije na kognitivnu funkciju i kvalitetu života trudnica kod uključenja u projekt, nakon porođaja i godinu dana nakon porođaja i njihove novorođenčadi i dojenčadi; d) Utvrđivanje utjecaja hipoglikemije na duljinu telomera u žena nakon porođaja i kod novorođenčeta. Istraživanjem će se utvrditi pojavnost i težina hipoglikemije u trudnica/rodilja/babinjača s T1DM-om u odnosu prema metaboličkoj kontroli uključujući maternalni i perinatalni ishod. Određivanjem C-peptida natašte i nakon jela te za vrijeme hipoglikemije uz ostale čimbenike kao što su kontinuirano mjerenje glukoze (CGM), trajanje dijabetesa, vrijednost HbA1c dobit će se siguran pretkazatelj nastanka hipoglikemije. Dobiven program edukacije i smjernice o pravodobnom prepoznavanju hipoglikemije koristit će se za prevenciju hipoglikemije u trudnica/babinjača. ]]></summary_hr><summary_en><![CDATA[Type 1 diabetes (T1DM) in pregnancy represents a burden for both a mother and a fetus. In order to accomplish a successful pregnancy outcome which includes delivery of healthy newborn, it is utmost importance to conduct the pre-pregnancy planning and achieve optimal glycemia in patient before conception, throughout pregnancy and in postpartum period. Nevertheless, the effort to reach the ideal glycemic control is often linked with increased risk of hypoglycemia which may lead to further maternal complications during pregnancy including coma, convulsions and death. The aim of this study is prevention and reduction of hypoglycemia prevalence in pregnant women with T1DM. Specific objectives include: a) establishing guidelines for prevention of hypoglycemia in pregnant women with T1DM based on biomarker potentials such as C-peptide, a reliable predictor of hypoglycemia; b) outlining the influence of hypoglycemia on cardiovascular neuropathy; c) identifying the influence of hypoglycemia on cognitive function and quality of life in pregnant women at booking, after delivery and one year after delivery, and in their newborns; d) determining the effect of hypoglycemia on telomere lengths in women after delivery, and their newborns an infants. PRE-HYPO consortium intends to provide a robust and evidence based data on incidence and clinical consequences of hypoglycemia in women with established T1DM during pregnancy/delivery/postpartum taking into an account metabolic control, maternal and perinatal outcome. The ambition of the proposal is to combine the results of the C peptide levels during fasting, post prandial and hypoglycemia events along with data from continuous glucose monitoring (CGM), duration of diabetes, HbA1c values in order to obtain reliable and realistic predictor of hypoglycemia. We will use specific training program and guidance for the timely recognition of hypoglycemia in order to prevent hypoglycemia in pregnant women. ]]></summary_en></project><project>
<id>7474</id><title_hr><![CDATA[Mikroskopska istraživanja induciranih faza u jako koreliranim elektronskim sustavima]]></title_hr><title_en><![CDATA[Microscopic study of induced phases in Strongly correlated electron systems]]></title_en><user_id>50</user_id><user_firstLast_name>Miroslav Požek</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2018-01</proposal_call><code>IP-2018-01-2970</code><acronim><![CDATA[MicroS]]></acronim><duration>01.10.2018 - 30.09.2023</duration><status>Završio</status><financ_value>153.958,46 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, </scie_field_hr><scie_field_en>Physics, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>3159, 3109, 3145, 3116, 17735, 23833, 25857, </team_members_id><team_members_names><![CDATA[Mihael Srđan Grbić, Damjan Pelc, Antonije Dulčić, Tonči  Cvitanić, Marija Vučković, Ana Najev, Ivan Jakovac, ]]></team_members_names><keywords_hr><![CDATA[jako korelirani elektronski sustavi, nuklearna magnetska rezonancija, tlak, kuprati, titanati, spinski lanci]]></keywords_hr><keywords_en><![CDATA[strongly correlated electron systems, nuclear magnetic resonance, pressure, cuprates, titanates, spin chains]]></keywords_en><summary_hr><![CDATA[Nove tehnologije počivaju na stalnom razvoju novih materijala, ali paradigmatični tehnološki skokovi se događaju kad se otkrivaju novi koncepti i/ili stanja tvari. Veliki teren za otkrivanje novih faza materije nalazimo među jako koreliranim elektronskim sustavima (SCES), natjecanje međudjelovanja i kvantne kritične pojave omogućuju bogatstvo uređenih stanja. Stoga je proučavanje koreliranih elektronskih sustava na samoj fronti istraživanja kondenzirane tvari.	SCES imaju vrlo složene fazne dijagrame s raznim kontrolnim parametrima kao što su temperatura, magnetsko polje, tlak ili dopiranje. Na faznim prijelazima fluktuacije mogu modificirati osnovna elektronska svojstva i stvoriti novu vrstu “kvantne kritične” materije, te time promijeniti svojstva materijala. Naša istraživanja usredotočit će se na nekoliko odabranih SCES tražeći odgovore na važna otvorena pitanja.	Proučavat ćemo okside trovalentnog titana, u kojima istaknuta pitanja obuhvaćaju magnetsku/orbitalnu kritičnu točku, ugađanje magnetizma i vodljivosti naprezanjem, te induciranu nisku spinsku dimenzionalnost. Naša istraživanja lantanovih kuprata trebala bi odrediti prirodu prijelaza između magnetskog izolatora i (supra)vodiča, te pokazati kako nabojno uređenje međudjeluje sa supravodljivošću pod tlakom u spoju dopiranom barijem. Istraživat ćemo i kvazi-1D Haldaneov spinski lanac s ciljem razumijevanja Bose-Einsteinove uređene faze i njezine evolucije u fazu s procjepom.	Popisu kontrolnih parametara koje već primijenjujemo u našem laboratoriju (temperatura, magnetsko polje, dopiranje) dodat ćemo izotropan i uniaksijalni tlak kako bismo istražili faze u nastajanju i fazne prijelaze. Upotrebljavat ćemo lokalne (NMR/NQR) i mezoskopske eksperimentalne metode (linearna i nelinearna vodljivost te toplinski kapacitet).	Projekt će rezultirati s nekoliko članaka u časopisima visoke kvalitete t dvjema doktorskim disertacijama. Usto, projekt će podići istraživačke kapacitete Fakulteta nabavom novog NMR spektrometra.]]></summary_hr><summary_en><![CDATA[New technologies rely on the continuing development of new materials, but technological paradigm shifts occur only when new concepts and/or states of matter are revealed. A large playground for discovering novel phases of matter is found in strongly correlated electron systems (SCES), where competing interactions and quantum criticality ensure an enormous wealth of ordering phenomena. The study of correlated electronic systems is thus on the forefront of condensed matter research.SCES display complex phase diagrams, with control parameters such as temperature, magnetic field, pressure or doping. At phase transitions, fluctuations can modify the basic properties of electrons and form new types of “quantum critical” matter, changing the overall properties of the material. Our research will focus on several prominent SCES, and will address important open questions.We will study trivalent titanium oxides, where the outstanding issues include a magnetic/orbital critical point, strain tuning of magnetism and conductivity, and induced low spin dimensionality. Our investigations of lanthanum copper oxides should determine the nature of the crossover between magnetic insulator and (super)conductor, and show how charge order and superconductivity interact in barium-doped compounds under pressure. We will also investigate a quasi-1D Haldane spin chain compound, aiming to understand the Bose-Einstein ordered phase and its evolution into the gapped phase.We will add isotropic and uniaxial pressure to the list of control parameters already used in our group (temperature, magnetic field, doping) to explore emergent phases and phase transitions. Experimental methods will include both local probes (NMR/NQR) and mesoscopic probes (linear and nonlinear conductivity, heat capacity).The project will result in several papers in high-quality research journals and two PhD theses. It will also increase the research capacities of the Faculty through the acquisition of a new NMR spectrometer.]]></summary_en></project><project>
<id>7477</id><title_hr><![CDATA[Imunosne i regenerativne implikacije korozije dentalnih materijala u djece i adolescenata]]></title_hr><title_en><![CDATA[]]></title_en><user_id>77</user_id><user_firstLast_name>Stjepan Špalj</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-01</proposal_call><code>DOK-2018-01-2531</code><acronim><![CDATA[IMUNODENT]]></acronim><duration>01.08.2018 - 31.07.2022</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Dentalna medicina, </scie_field_hr><scie_field_en>Dental medicine, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Medicine]]></institution_en><team_members_id>25209</team_members_id><team_members_names><![CDATA[ Doktorand: Martina Žigante ]]></team_members_names><keywords_hr><![CDATA[allergy, antibiotic resistance, nickel exposure, titan exposure, corrosion]]></keywords_hr><keywords_en><![CDATA[allergy, antibiotic resistance, nickel exposure, titan exposure, corrosion]]></keywords_en><summary_hr><![CDATA[Pomicanje zubi napravama baziranim na niklu i titanu ima veliki osteogeni potencijal i može regenerirati deficijentne dijelove alveolarne kosti i gingive te rehabilitirati narušene okluzijske odnose i žvačnu funkciju pacijenta. Zbog dugotrajnosti takve terapije paralelno se primjenjuju postupci i materijali za prevenciju te regeneraciju oštećene cakline i oralnih sluznica. Usna šupljina može se smatrati galvanskim člankom gdje su dentalne slitine elektrode, a elektrolit čine slina te oralni preventivni i regeneracijski agensi. Interakcija uzrokuje koroziju, smanjenje elastičnosti naprava, produkciju prevelikih sila, poremećaj regeneracije tikiva i nepopravljive štete na korijenu zuba, parodontu i kosti. Tijekom dugotrajne eksponiranosti otpušteni korozivni produkti u okolnim tkivima te transportirani slinom i krvlju mogu izazvati cijeli niz nusefekata. Alergije su danas sve češće i javljaju se sve ranije, a posebna skupina su djeca i mladi adolescenti u periodu pubertetskog rasta kada se razvija i imunološki sustav. Nikal je dugo poznati alergen i prisutan je u brojnim dentalnim legurama. Alergija na nikal događaje su u do 28.5% populacije i ne može se više smatrati niskim potencijalnim rizikom. U posljednje vrijeme reportira se i alergija na titan, za koji se smatralno da je biokompatibilan, a izloženi su mu brojni pacijenti s endoprotezama kuka, stentovima, dentalnim implantatima i ortodontskim napravama. Alergija na titan može biti odgovorna za neobjašnjene slučajeve neuspjeha i odbacivanja dentalnih implantata. Nikal i titan mogu uzrokovati rezistenciju bakterija na antibiotike što može stvarati probleme u terapiji niza infekcija koje su češće u djece i adolesceanta. Cilj je ovog projekta ispitati u kojoj mjeri i kojim mehanizmima korozija dentalnih materijala baziranih na niklu i titanu izaziva prethodno navedene biološke učinke.]]></summary_hr><summary_en><![CDATA[Tooth movement, based on nickel-titanium appliance, has great osteogenic potential, it can regenerate deficient alveolar bone sites and gingiva, rehabilitate deficient occlusal relationships and masticatory function. Due to prolonged therapy materials and techniques for prevention and regeneration of damaged enamel and oral tissues are concurrently used. Oral cavity can be considered as a galvanic cell, where saliva is electrolyte and dental alloys and oral agents are galvanic coupling components. Decreasing elasticity of orthodontic wires due to intraoral corrosion can produce excessive forces and therefore can disturb regeneration of tissues and irreparable damage to root and surrounding periodontium and bone. Due to long-term exposure corrosive products are released into adjacent tissues, saliva and blood. There from a number of undesired side effects can develop. Nowadays, the allergies occur more often and onset earlier during a lifetime. Children and young adolescents are undergoing pubertal growth, changes and maturation of immune system and particular attention should be paid to their exposure. Nickel has been well known allergen, present in many dental alloys. Nickel allergic hypersensitivity occurs in up to 28.5% of the population and it cannot be considered a low potential risk. Lately, allergic reactions to titanium were reported in patients with endoprosthesis and dental implants, contrary to the previously established biocompatibility. The occurrence of an allergy to titanium could be responsible for successive unexplained cases of failure of dental implants. Nickel and titan can enhance resistance of some bacteria to antibiotics which can produce problems in treatment of several infections that are more common in children and adolescents. The aim of this project is to explore to what extent and by which mechanisms does corrosion of dental materials based on nickel and titan produce above mentioned biological effects.]]></summary_en></project><project>
<id>7479</id><title_hr><![CDATA[Oscilatorna dinamika citoskeleta]]></title_hr><title_en><![CDATA[]]></title_en><user_id>7715</user_id><user_firstLast_name>Igor Weber</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-01</proposal_call><code>DOK-2018-01-6409</code><acronim><![CDATA[OSCITON]]></acronim><duration>01.10.2018 - 31.12.2022</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Biologija, </scie_field_hr><scie_field_en>Biology, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>25284</team_members_id><team_members_names><![CDATA[ Doktorand: Lucija Mijanović ]]></team_members_names><keywords_hr><![CDATA[citoskelet, mikrotubuli, motorni proteini, diobeno vreteno, stanično kretanje, Rho GTPaze, mikroskopija, teorijsko modeliranje]]></keywords_hr><keywords_en><![CDATA[cytoskeleton, microtubules, motor proteins, mitotic spindle, cell migration, Rho GTPases, microscopy, theoretical modeling]]></keywords_en><summary_hr><![CDATA[Oscilacije u citoskeletu važne su za biologiju stanice kao sredstvo prostorne i vremenske regulacije stanične organizacije, diobe stanica i njihove pokretljivosti. U projektu OSCITON istraživat ćemo dva oscilatorna procesa. Kao prvo, proučavat ćemo mehanizam oscilacija kinetohora koje pokreću mikrotubuli tijekom mitoze, te utjecaj kinezina-8 na taj proces. Te oscilacije stvaraju sile napetosti između sestrinskih kinetohora, bez kojih stanica ne može proći kontrolnu točku u metafazi. Oscilacije ćemo proučavati uz pomoć naprednih tehnika svjetlosne mikroskopije u HeLa stanicama u kojima ćemo eksprimirati tubulin-GFP i kinetohorni protein mRFP-Cenp-B, te smanjiti ili pojačati ekspresiju kinezina-8. Da bismo proučavali sile koje djeluju na kinetohore, promijenit ćemo ravnotežu sila laserskom mikrodisekcijom mikrotubula vezanih na kinetohore. Paralelno s eksperimentima razvit ćemo teorijski model, koji će omogućiti interpretaciju utjecaja kinezina-8 na oscilacije. Kao drugo, proučavat ćemo oscilatornu repolarizaciju stanica Dictyostelium tijekom njihovog nasumičnog gibanja. Pretpostavljamo da kompeticija efektorskih kompleksa DGAP1/korteksilin i Scar/Wave za zajednički aktivator Rac1 igra središnju ulogu u repolarizaciji. Kako bismo testirali ovu hipotezu, koristit ćemo novu fluorescentnu sondu za aktivni Rac1, stanice s poremećenom ravnotežom efektorskih kompleksa, te stanice sa reduciranom funkcionalnošću proteina Rac1. Eksperimentalno i teorijski ćemo proučavati dinamiku Rac1, njegovih efektora, te F-aktina u stanicama divljeg tipa i mutiranih sojeva. Ovaj će interdisciplinarni projekt omogućiti optimalno korištenje resursa i okupiti znanstvenike s iskustvom u širokom rasponu disciplina od molekularne i stanične biologije, biokemije, mikroskopije do teorijske biofizike. Udruživanjem svih istraživača iz područja dinamike citoskeleta u Hrvatskoj okupit ćemo tim koji će igrati važnu ulogu u tom području istraživanja na međunarodnoj razini.]]></summary_hr><summary_en><![CDATA[Oscillations in the cytoskeleton are of general importance in cell biology as a means of spatial and temporal regulation of the cellular organization, cell division and motility. The project OSCITON focuses on two oscillatory processes. First, we will investigate the mechanism of microtubule-driven kinetochore oscillations during mitosis, and the role of kinesin-8 motors in this process. These oscillations generate tension between sister kinetochores, which is required to pass the spindle checkpoint. We will use HeLa cells expressing tubulin-GFP and mRFP-CENP-B, a kinetochore protein, in combination with advanced light microscopy and depletion or overexpression of kinesin-8 motors. To study the forces acting on kinetochores, we will perturb the force balance by performing laser microsurgery of the microtubules attached to kinetochores. The experiments will be accompanied by the development of a theoretical model, which will allow us to explore the role of kinesin-8 in the oscillations. Second, we will study the oscillatory repolarization of Dictyostelium cells during random migration. We propose that the competition of DGAP1/cortexillin and SCAR/Wave complexes for the common activator Rac1 plays a central role in this process. To test this hypothesis, we will use a novel fluorescent probe for active Rac1 GTPases, generate cells with disturbed balance of Rac1 effectors, and cells deficient in functional Rac1. Dynamics of the probes for Rac1, its effectors, and F-actin will be studied experimentally in live cells and theoretically. This interdisciplinary project is designed to optimize the use of resources and bring together researchers with the expertise in a range of disciplines, including molecular and cellular biology, biochemistry, microscopy, and theoretical biophysics. Through joining forces of all investigators of the cytoskeletal dynamics in Croatia, we intend to assemble a team that will play a prominent role in this field of research internationally.]]></summary_en></project><project>
<id>7483</id><title_hr><![CDATA[Određivanje fizikalno-kemijskih svojstava i toksičnosti nanočestica srebra, bakra i plastike kao potencijalno štetnih novih materijala u obalnim vodama]]></title_hr><title_en><![CDATA[Understanding the physico-chemical behaviour and toxicity of silver, copper and plastic NANOparticles as Emerging Materials of Concern in coastal waters]]></title_en><user_id>4961</user_id><user_firstLast_name>Daniel Lyons</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2018-01</proposal_call><code>IP-2018-01-5351</code><acronim><![CDATA[NANO-EMC2]]></acronim><duration>01.10.2018 - 31.12.2022</duration><status>Završio</status><financ_value>120.656,31 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Interdisciplinarne prirodne znanosti, Fizika, Kemija, Biologija, </scie_field_hr><scie_field_en>Interdisciplinary natural sciences, Physics, Chemistry, Biology, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>556, 439, 119, 528, 546, 11303, 12729, 4614, 17878, 28141, 858380, 865123, </team_members_id><team_members_names><![CDATA[Bojan Hamer, Dijana Pavičić-Hamer, Lorena Perić, Petra Burić, Ines Kovačić, Biljana Balen, Petra Peharec Štefanić, Petra Cvjetko, Lara Jurković, Ivana Hazdovac, Bruno Komazec, Matea Marelja, ]]></team_members_names><keywords_hr><![CDATA[istraživanja mora i ušće rijeke, nanočestica, nanoplastika, kinetika, toksičnost, bioakumulacija, klimatske promjene ]]></keywords_hr><keywords_en><![CDATA[marine and estuarine research, nanoparticle, nanoplastic, kinetics, toxicity, bioaccumulation, climate change]]></keywords_en><summary_hr><![CDATA[Usporedno s rastućom uporabom proizvoda koji sadrže nanočestice, očekuje se značajno povećanje njihovog oslobađanja u okolinu. Mnoga istraživanja vezana za ponašanje i sudbinu umjetno proizvedenih nanočestica (engl. engineered nanoparticles, ENPs) usmjerena su na kopnene vodene sustave (jezera, rijeke i podzemne vode) zbog očekivanja da će se nanočestice oslobođene u okolinu s vremenom razgraditi u tim istim sustavima bez značajnog prijenosa na ostale dijelove okoliša. Međutim, uzimajući u obzir mnoga nastanjena mjesta u obalnim područjima, potencijalno opterećenje velikom količinom nanočestica u ušćima rijeka kao i priobalnim vodama u nadolazećim godinama sve je značajnije. Budući da postoje dokazi da različite nanočestice mogu biti toksične za brojne organizme, posebno osjetljivi bi mogli biti organizmi u ušćima rijeka i u priobalnim područjima. Međutim, dostupne informacije vezane za ponašanje nanočestica u elektrolitima velike ionske jakosti, posebice učinak koji mogu imati njihovi omotači na koloidnu stabilnost, specijaciju i kinetiku, malobrojne su i nedorečene. Nadalje, trenutno postoji veoma malo raspoloživih podataka o međusobnom djelovanju nanočestica s širokim rasponom raznih organizama u bočatoj i obalnoj vodi. Ovaj će projekt istražiti fizikalno-kemijsko ponašanje nanočestica srebra, bakra i polimera/plastike različitih veličina i površinskih omotača, kao potencijalno opasnih materijala u vodenom stupcu bočatih i obalnih voda, uzevši u obzir abiotičke čimbenike kao što su salinitet, pH, koncentracija kisika i otopljena organsku tvar. Standardizirani biokemijski testovi, prilagođeni specifičnim svojstvima i učinku interferencije ENP, koristiti će se za mjerenje širokog raspona indikatora toksičnosti na izabrane organizme od algi i makroalgi do ježinaca, školjkaša i rakova. Ovim projektom omogućit će se po prvi puta cjelokupni pregled ponašanja nanočestica srebra, bakra i plastike u bočatoj vodi kao kompleksnoj zoni prijelaza iz slatkovodne u morsku vodu.]]></summary_hr><summary_en><![CDATA[In parallel with the growing use of nanoparticle-containing products, their release into the environment over the coming years is expected to increase significantly. Much of the research on the behaviour and fate of engineered nanoparticles (ENPs) in the environment has focused on terrestrial aquatic systems (lakes, rivers and groundwater) due to the expectation that ENPs would eventually be degraded in these systems without significant transport to other environmental compartments. However, with many large population centres located in near-coastal areas, the potential environmental load of nanoparticles in estuarine and coastal waters over the coming years is enormous. As there is increasing evidence that various nanoparticles may be toxic to a range of organisms, biota in estuarine and coastal waters may thus be particularly vulnerable. However, available data on how nanoparticles behave in high strength electrolytes, in particular the effect of their coating on colloidal stability, speciation or ion release kinetics are scarce. Further, there is little data on how such aged nanoparticles interact with the wide range of diverse organisms in brackish and coastal waters.This project will investigate the physico-chemical behaviour of silver, copper and polymer/plastic nanoparticles with a range of different sizes and surface coatings, as materials of concern, in brackish and marine waters based on a range of abiotic factors including salinity, pH, oxygen concentration and dissolved organic matter. Standardised biochemical tests, adapted to take into account the specific properties and interference effects of ENPs, will be used to measure a range of toxicity endpoints in selected organisms ranging from algae and macroalgae to urchins, mussels and crabs. The results from this project will provide for the first time a systematic overview of the behaviour of silver, copper and plastic nanoparticles in brackish water as a complex transition zone from fresh to salt water.]]></summary_en></project><project>
<id>7484</id><title_hr><![CDATA[Sinteza naprednih anorganskih katalizatora s povećanim brojem kiselih mjesta]]></title_hr><title_en><![CDATA[]]></title_en><user_id>609</user_id><user_firstLast_name>Josip Bronić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-01</proposal_call><code>DOK-2018-01-1739</code><acronim><![CDATA[SAdInCat]]></acronim><duration>05.09.2018 - 31.12.2022</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, </scie_field_hr><scie_field_en>Chemistry, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>25291</team_members_id><team_members_names><![CDATA[ Doktorand: Glorija Medak ]]></team_members_names><keywords_hr><![CDATA[zeolitni katalizatori, hijerarhijski zeoliti, hibridni materijal, nano-zeoliti, mokra impregnacija, converzija metanola u olefine, ]]></keywords_hr><keywords_en><![CDATA[zeolite catalyst, hierarchical zeolites, hybrid materijal,  nano-zeolites, wet impregnation, methanol to olefin conversion, ]]></keywords_en><summary_hr><![CDATA[Zeoliti su mikroporozni alumino-silikatni materijali vrlo dobro definirane kristalne strukture i termičke stabilnosti. Zahvaljujući svojoj strukturi, kanali i otvori pora mogu biti raznih veličina (0.2-1.3 nm) i oblika. Broj dostupnih Lewis-ovih (kadkad i Bronsted-ovih) kiselih mjesta na čvrstim katalzatorima, kao što su zeoliti, je od najveće važnosti za efikasnost katalizirane organske reakcije. U cilju razjašnjenja utjecaja različitih zeolitnih struktura (MFI, MOR, BEA, FAU) na katalitička svojstva za pretvorbu metanola u olefin, sintetizirat će se kristali različitih zeolita (ZSM-5, mordentie, beta, ZY) mikrometarske veličine. Poboljšanje njihovih katalitičkih mogućnosti će se realizirati sustavnim studiranjem preko dva pristupa: - povećanjem dostupne površine na kristalima i - povećanjem broja kiselih mjesta.Površina kristala može se povećati kroz redukciju njihove veličine (kroz sintezu nanometarskih kristala) ili pravljenjem većih pora na kristalima mikrometarske veličine. Mezoporoznost kristala će se postići sintezom hierarhijskih zeolita koristeći dva (ili više) templata za sintezu, kao i tehnikom dealuminacije/desilikacije. Drugi način povećanja broja kiselih mjesta u pripravljenim zeolitima je uvođenje određenih kationa metala (Ti, Zr, Fe, Sn) koristeći ionsku zamjenu u čvrstom stanju metodom mljvenja i/ili mokrom impregnacijom. Broj katalitičkih kiselih mjesta će se određivati uporabom vacuum FTIR spektroskopije adsorbiranog piridina ili sličnih organskih molekula.Dodatni post-sintetski tretman pripravljenih hierarhijskih zeolita, provodit će se ugradnjom nanometarskih čestica metalnih-oksida (priređenih sol-gel postupkom) u njih da čine hibridne (kompozitne) katalizatore. Mnoge tehnike/metode će se koristiti za karakterizaciju strukturnih, čestičnih i katalitičkih svojstava uzoraka: PXRD, AAS, OM, SEM, TEM, LLS, FTIR, DR-UV/Vis, NMR, TG-DTG, N2 adsorption/desorption, PALS.]]></summary_hr><summary_en><![CDATA[Zeolites are microporous alumino-silicate materials of very well defined crystal structure and thermal stability. Due to their structure, a crystal channels and pore openings can be of various size (0.2-1.3 nm) and shape.The number of available Lewis&#39; (sometimes Bronsted) acid sites at solid state catalysts, such as zeolites, is crucial for efficiency of catalysed organic reactions. In order to elucidate the role of different zeolite structures (MFI, MOR, BEA, FAU) on catalytic properties for methanol to olefin conversion, various micrometer sized zeolite crystals (ZSM-5, mordentie, beta, ZY) will be synthesized. Improvement of their catalytic abilities will be realized by systematic study via two approaches: - increase of available surface at crystals, and - increase of the number of acid sites.The crystals surface can be enlarged through reduction of its size (by synthesis of nanometer sized crystals) or by creation of larger pores on micrometer sized crystals. Mesoporosity of the crystals will be obtained by synthesis of hierarchical zeolites using dual (or multi) template synthesis and by dealumination/desilication technique. Another way to increase the number of acid sits in prepared zeolites is introduction of certain metal cations (Ti, Zr, Fe, Sn) exploiting solid state ion exchange via grinding or/and via wet impregnation. The number of catalytic acid sites will be determined using vacuum FTIR spectroscopy of adsorbed pyridine or similar probe molecules.Additional post-synthesis treatment of obtained hierarchical zeolites will be done through incorporation of the nanometer sized metal-oxides (obtained by sol-gel method) to form hybrid (composite) catalyst. Many techniques/methods will be used for characterization of samples structural, particulate and catalytic properties, such as: PXRD, AAS, OM, SEM, TEM, LLS, FTIR, NMR, DR-UV/Vis, TG-DTG, N2 adsorption/desorption, PALS.]]></summary_en></project><project>
<id>7488</id><title_hr><![CDATA[Semantičke domene deiktičkih riječi: Istraživanje brzih semantičkih procesa u jeziku ]]></title_hr><title_en><![CDATA[Semantic domains of deictic terms: Investigating the nature of fast meaning processes in language]]></title_en><user_id>7114</user_id><user_firstLast_name>Marija Brala-Vukanović</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2018-01</proposal_call><code>IP-2018-01-2243</code><acronim><![CDATA[DeicTeS]]></acronim><duration>01.11.2018 - 31.10.2022</duration><status>Završio</status><financ_value>39.575,29 eur</financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Interdisciplinarne humanističke znanosti, Filozofija, Filologija, </scie_field_hr><scie_field_en>Interdisciplinary humanities, Philosophy, Philology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Filozofski fakultet u Rijeci]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Humanities and Social Sciences]]></institution_en><team_members_id>23887, 5309, 23898, 28939, 4040, </team_members_id><team_members_names><![CDATA[Peter Gärdenfors, Mihaela Matešić, Danijela  Trenkic, Biljana Stojanovska, Ana Meštrović, ]]></team_members_names><keywords_hr><![CDATA[deikse, kognitivna semantika, brzosemantičko procesiranje, demonstrativi, odnos jezika i geste]]></keywords_hr><keywords_en><![CDATA[deixis, cognitive semantics, fast semantic processing, demonstratives, language - gesture ralation]]></keywords_en><summary_hr><![CDATA[Deikse u jeziku i njihova semantika sržna su tema ovoga projekta. Polazeći od teorije prema kojoj se deiktičkim riječima pridjeljuje značenje tzv. brzim semantičkim procesom, analiziraju se deiktičke riječi u odabranim jezicima: engleskome, talijanskome, hrvatskome, makedonskome, bugarskome i njemačkome. Analiza se provodi korpusnim metodama te zatim introspektivno, s ciljem konstruiranja značenjske radijalne mreže svake proučavane deiktičke kategorije i deiktičke riječi. Na temelju teorijskoga i introspektivnoga pristupa provodi se zatim i empirijsko istraživanje koje ima za cilj proučiti psiholingvističke aspekte brzoga semantičkog procesiranja.Istraživanjem provedenim na opisani način donose se novi uvidi u: a) značenjske domene koje se izražavaju deiktičkim riječima, b) kognitivne i jezične mehanizme koji su uključeni u brze semantičke procese, c) razliku između brzih i sporih semantičkih jezičnih procesa, d) razlike između semantičkih i pragmatičkih funkcija deiktičkih riječi.Sve u svemu, cilj je projekta pružiti nove spoznaje o strukturi deiktičkih riječi, njihovim funkcionalnim (gramatičkim), semantičkim i pragmatičkim obilježjima. Poseban je cilj pritom pridonijeti daljnjemu razumijevanju strukture deiktičkoga sustava upravo hrvatskoga jezika. Projektom se stoga omogućuje i veća vidljivost te dostupnost hrvatskoga jezičnog materijala u (kognitivno)lingvističkome istraživačkom prostoru u međunarodnoj zajednici. Naposljetku, ovakav sustavan lingvistički opis strukturnih (funkcionalnih, semantičkih i pragmatičkih) aspekata deiksa primjenjiv je i u drugim znanstvenim područjima i poljima, ponajprije u psihologiji i neurolingvistici. Povezivanjem sa suvremenim istraživanjima neurolingvističkih procesa koji upravljaju proizvodnjom i recepcijom deiktičkih riječi,  rezultati ovoga projekta iskoristivi su također na područjima jezičnoga poučavanja te rehabilitacije govora.]]></summary_hr><summary_en><![CDATA[The focus of this project is on deixis in language. Following the position that deictic terms are given meanings by the fast semantic process, we will analyse deictic words in a set of languages (English, Italian, Croatian, Macedonian, Bulgarian, and German). Methodologically, an initial literature review will be followed by corpus analysis, subsequently followed by introspective data analysis. The aim is to construct a motivated radial network for each deictic term and, subsequently, each deictic category, under examination. The theoretical and introspective segment of project activities will be followed by work on an empirical study, aimed at investigating the psycholinguistic aspects of fast semantic processing.The investigation is aimed at providing new insights into: a) the semantic domains expressed by deictic words; b) the cognitive and linguistic mechanisms involved in fast semantic processes; c) the difference between fast and slow linguistic processes d) the differences between semantic and pragmatic functions of deictic terms.Ultimately, the objective of the project is to provide new insights into the structure of deictic terms; their functional (grammatical), semantic and pragmatic features, but also, more specifically, to contribute to the understanding of the structure of the deictic system in the Croatian language, thus providing visibility and availability of the Croatian data. Finally, by providing a detailed account of the structural (functional, semantic and pragmatic) elements of deictic elements in language, we also hope to offer useful insights for psychologists and neurolinguistics. In fact, one of air aims is to link our findings to the current knowledge regarding the neurolinguistic processes underlying the production and reception of deictic terms, hopefully providing useful information for fields outside linguistics, e.g. language teaching methodology or speech therapy.]]></summary_en></project><project>
<id>7489</id><title_hr><![CDATA[Biokemijski odgovori površinskog sloja oligotrofnog područja Jadranskog mora na atmosfersko taloženje]]></title_hr><title_en><![CDATA[Biochemical responses of oligotrophic Adriatic surface ecosystems to atmospheric deposition inputs]]></title_en><user_id>84</user_id><user_firstLast_name>Sanja Frka Milosavljević</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2018-01</proposal_call><code>IP-2018-01-3105</code><acronim><![CDATA[BiREADI]]></acronim><duration>29.10.2018 - 28.10.2022</duration><status>Završio</status><financ_value>132.722,81 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Interdisciplinarne prirodne znanosti, Kemija, Biologija, Geofizika, </scie_field_hr><scie_field_en>Interdisciplinary natural sciences, Chemistry, Biology, Geophysics, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>17873, 5789, 986, 23793, 23794, 17849, 23380, 23367, 85, 81, 106, 4294, 23848, 25777, 25845, </team_members_id><team_members_names><![CDATA[Ana  Cvitešić Kušan, Sanda Skejić, Tvrtko Smital, Sonja Vidič, Vedrana Džaja Grgičin, Tihana Novak, Ranka Godec, Silva Žužul, Abra Penezić, Blaženka Gašparović, Slađana Strmečki Kos, Ivan Bešlić, Stjepana Brzaj, Andrea Milinković, Saranda Bakija Alempijević, ]]></team_members_names><keywords_hr><![CDATA[atmosfersko taloženje, površinski (mikro)sloj mora, Jadransko more, fitoplankton, hranjive soli, organska zagađivala, tragovi metala, površinski film]]></keywords_hr><keywords_en><![CDATA[atmospheric deposition, sea surface (micro)layer, Adriatic Sea, phytoplankton, macronutrients, organic pollutants, trace metals, surface films]]></keywords_en><summary_hr><![CDATA[Najizazovnija područja istraživanja globalnih klimatskih promjena danas uključuju kompleksna međudjelovanja biologije i kemije površinskih voda, atmosferske kemije te klime koja bi mogla imati još veći značaj u budućim klimatskim scenarijima. Koristeći multidisciplinarni, cjeloviti pristup, BiREADI ima za cilj ispitati utjecaje atmosferskog taloženja (AT) na složene biokemijske odgovore oligotrofnih vodenih sustava; primarno fitoplanktonskih zajednica te, posljedično, i na kemijske promjene u površinskim slojevima, uključujući mikrosloj na granici faza zrak-voda. Predložen je fazni pristup i specifični ciljevi: (I) procijeniti koncentracije, izvore i taložne tokove atmosferskih sastavnica te prirodu obogaćenja površinskih slojeva mora hranjivim solima, tragovima metala i organskim zagađivalima, (II) procijeniti utjecaje okolišnog AT na fiziologiju i biomasu prirodne planktonske populacije, a time i na kemiju površinskih slojeva mora, (III) dobiti uvid u mehanizme kojima AT utječe na morski fitoplankton, ali i procijeniti toksične učinke sinergijskog djelovanja atmosferskih zagađivala na različite razine biološke organizacije vodenih sustava, (IV) bolje razumijevanje prirode varijabilnosti biogene organske tvari  vodenih površinskih slojeva pod utjecajem AT te mehanizama stvaranja površinskih filmova i njihovih svojstava. BiREADI će značajno doprinijeti temeljnom razumijevanju povezanosti procesa AT i biokemijskih odgovora morskih površinskih sustava primjenom najsuvremenijih laboratorijskih ispitivanja, modeliranja, složenog terenskog rada, uključujući i mezokozmos na području srednjeg Jadrana–oligotrofnoj zoni i ključnom području proučavanja biokemijskih učinaka AT na Jadransko more.]]></summary_hr><summary_en><![CDATA[Complex interactions between surface water chemistry, phytoplankton, atmospheric chemistry, and climate are among the most challenging global climate issues today, and should become even more pronounced in future climate scenarios. With a holistic, multidisciplinary approach, the BiREADI is designed to assess the impact of atmospheric deposition (AD) on complex biochemical responses of oligotrophic systems, considering the importance of promotion and inhibition effects on phytoplankton, and the consequent altering of the surface water chemistry, including the sea surface microlayer at the air-water interface. To achieve the main project goals, a phased approach is proposed: Phase I - to evaluate concentrations, sources and deposition fluxes of atmospheric constituents, and to get insight into the nature of enrichments of macro-nutrients, trace metals and organic pollutants within the sea surface layers; Phase II - to assess the impact of ambient AD from diverse sources on the physiology and biomass of the natural plankton population, and consequently on the chemistry of the sea surface layers; Phase III - to get insight into the mechanisms by which AD affects marine phytoplankton, but also to assess the toxic effects of atmospheric pollutants that can interact synergistically on various levels of biological organisation in aquatic systems; Phase IV - to better understand the nature of biogenic OM variabilities within the aqueous surface layers affected by AD inputs with the consequences on the surface film formation and properties. The BiREADI will make a significant progress in the fundamental understanding of the linkage between AD inputs and complex surface ocean biochemical responses by a state-of-the-art laboratory and modelling studies, and by comprehensive field work including the mesocosm experiment at the Middle Adriatic - an extremely oligotrophic water zone and the «hotspot» area to study the biochemical effects of AD to the Adriatic Sea.]]></summary_en></project><project>
<id>7496</id><title_hr><![CDATA[Ciljano liječenje, stanični mikrookoliš i tumorska distribucija u kroničnoj limfocitnoj leukemiji (B-KLL) ]]></title_hr><title_en><![CDATA[Targeted therapy, cell microenvironment and tumor distribution in B-cell chronic lymphocytic leukemia (B-CLL)]]></title_en><user_id>1222</user_id><user_firstLast_name>Ozren Jakšić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2018-01</proposal_call><code>IP-2018-01-3453</code><acronim><![CDATA[TTMTDCLL]]></acronim><duration>01.10.2018 - 31.03.2024</duration><status>Završio</status><financ_value>108.832,70 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Kliničke medicinske znanosti, Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Clinical sciences, Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Klinička bolnica "Dubrava", Zagreb]]></institution_hr><institution_en><![CDATA[Dubrava Clinical Hospital, Zagreb]]></institution_en><team_members_id>6760, 6139, 4556, 19193, 4697, 7198, 5917, 6578, 6577, 19259, 23847, 23838, 6997, </team_members_id><team_members_names><![CDATA[Vlatko Pejša, Silvia Deaglio, Branimir Jakšić, Renata Huzjan Korunić, Branimir Gizdić, Vlatka Pandžić Jakšić, Zdravko Mitrovic, Mario Piršić, Zorana Miletić, Anteja Krištić, Marija Ivić, David Čičić, Željko Prka, ]]></team_members_names><keywords_hr><![CDATA[KLL, mikrookoliš, ciljano liječenje, tumorska distribucija, B-receptor, bcl-2]]></keywords_hr><keywords_en><![CDATA[CLL, microenvironment, targeted therapy, tumor distribution, B receptor, bcl-2]]></keywords_en><summary_hr><![CDATA[Fenomen  tumorske distribucije (TD) u B-kroničnoj limfocitnoj leukemiji (B-KLL) usko je povezan s interakcijom između neoplastičnih B-KLL stanica i odgovarajućeg mikrookoliša (ME) što je sada u središtu translacijskog istraživanja zbog intrigantnih implikacija na novu terapijsku paradigmu. Predloženo istraživanje predstavlja inovativni pristup istraživanju uloge TD i ME u B-KLL. Ciljevi su ispitati neovisni doprinose i učinke (1) kvantificirane TD primjene na aktualne standardne kriterije praćenje kao i na identifikaciju ranih prediktora odgovora na nove terapije; (2) ekspresijskog profila površinskih receptora / liganda te unutarstaničnih molekula B-KLL limfocita na objašnjenje razlika koje proizlaze iz uzorkovanja iz različitih mikrookoliša (intraklonalna raznolikost) i (3) dinamike ekspresijskog profila molekula na objašnjavanje promjena koje proizlaze iz nove terapijske intervencije. Praćenjem kohorte B-KLL bolesnika klinički i radiološki vrednovat ćemo kriterije za praćenje i prognostičke prediktore. Imunofenotipizacijom  protočnom citometrijom i imunocitno- i histokemijom odredit će se profil adhezijskih molekula, kemokinskih receptora, bcl-2 molekula i drugih relevantnih površinskih i unutarstaničnih molekula. Analizom i povezivanjem podataka na kliničkoj i staničnoj razini prikladnim univarijatnim, multivarijatnim te istraživačkim tehnikama upotrijebit će se za karakterizaciju biološke pozadine raspodjele tumora i odgovora na nove terapije. Očekivani doprinos istraživanja je u poboljšanju kriterija dijagnostike i praćenja te ranih prediktora odgovora na nove lijekove. Ovi rezultati mogu se lako provesti u kliničkoj praksi. Na staničnoj razini očekujemo doprinos boljem razumijevanju molekularnih mehanizama kruženja i nastanjivanja B-KLL limfocita te odgovora na ciljanu terapiju. Ovi rezultati mogu pomoći u prepoznavanju, karakterizaciji, modeliranju i ciljanju važnih B-KLL signalnih putova.]]></summary_hr><summary_en><![CDATA[The phenomenon of Tumor Distribution (TD) in B-chronic lymphocytic leukemia (B-CLL) is closely related to interaction between neoplastic B-CLL cells and respective microenvironment (ME) and is now in the focus of translational research because of the intriguing implications on new therapeutic paradigm. The proposed research presents an innovative approach to study the role of TD and ME in B-CLL. Objectives are to investigate independent contribution and effects of (1) quantified TD application on current standard monitoring criteria improvement and to identification of early response predictors for novel therapies; (2) the B-CLL lymphocytes surface receptor/ligands and intracellular molecules expression profile on explanation of differences resulting from different sampling microenvironment (intraclonal diversity) and (3) molecule expression profile dynamics on explanation of changes resulting from new treatment intervention. We will evaluate clinically and radiologically cohort of patients to study monitoring criteria and prognostic predictors. Immunophenotyping by flow cytometry and immunocyto- and histochemistry will be used to determine profiles of adhesion molecules, chemokine receptors, bcl-2 molecules and other relevant surface and intracellular molecules. Appropriate univariate and multivariate analysis, exploratory techniques relating data at clinical and cellular level will be used for characterization of biological background of tumor distribution and response to novel treatments. We expect contribution in improving of diagnostic and follow-up criteria and early response predictors for novel treatments. These results can be readily implemented in clinical practice. At a cellular level we expect the contribution to better understanding of molecular mechanisms of B-CLL trafficking and homing and response to the targeted therapy. These results may help identification, characterization, modeling and targeting important B-CLL signaling pathways.]]></summary_en></project><project>
<id>7502</id><title_hr><![CDATA[Frakcionalni analogni i mješoviti sustavi obrade signala]]></title_hr><title_en><![CDATA[]]></title_en><user_id>6508</user_id><user_firstLast_name>Dražen Jurišić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-01</proposal_call><code>DOK-2018-01-4665</code><acronim><![CDATA[FractalAnalogFilters]]></acronim><duration>01.09.2018 - 01.09.2021</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Elektrotehnika, </scie_field_hr><scie_field_en>Electrical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id>21276</team_members_id><team_members_names><![CDATA[ Doktorand: Edi Emanović ]]></team_members_names><keywords_hr><![CDATA[Analogni i mješoviti krugovi, Aktivni električni filtri, Analogno sučelje, Cadence, PSpice]]></keywords_hr><keywords_en><![CDATA[Analog and mixed circuits, Active electrical filters, Analog front end,  Cadence, PSpice]]></keywords_en><summary_hr><![CDATA[U predloženom projektu će se istraživati nove metode projektiranja vremenski kontinuiranih aktivnih analognih filtara necjelobrojnog (frakcionalnog) reda za analogno sučelje u komunikacijskim sustavima. Do sada su takvi sustavi bili cjelobrojnog reda, a u ovom projektu će se izvršiti poopćavanje na necjelobrojni red. U najnovijim publikacijama dokazano je da su takve metode poželjne, ali u mnogim primjenama postoje ograničenja zbog izvedivosti frakcionalnih komponenata koji nisu još u komercijalnoj uporabi. Osim problema u proizvodnji frakcionalnih komponenata postoje i neriješeni matematički problemi kao što su analiza osjetljivosti, šuma, te stabilnosti necjelobrojnih sustava. U integriranoj realizaciji se ti problemi posebno uočavaju (visoke osjetljivosti na tolerancije komponenata, nestabilnost zbog parazita) i pozivaju na nove, nekonvencionalne i kreativne tehnike realizacije. Posebno ćemo se u istraživanju usredotočiti na analogni dio mješovitih elektroničkih sklopova, kao dio &#39;analognog sučelja&#39; prema vanjskom analognom svijetu. Pokazati ćemo da se primjenom teorije električnih krugova i linija mogu postići razna predložena poboljšanja. Istraživanja u početku će biti cjelobrojna, a zatim ćemo se koristiti frakcionalnim računom kako bi dobili što veću fleksibilnost i dodatni stupanj slobode u projektiranju. Pomoću teorije fraktala predložiti ćemo novu Besselovu filtarsku aproksimaciju. Kao rezultat projekta, uz navedena nova teoretska dostignuća, dva integrirana kruga koja služe za verifikaciju teorije, realizirat će se u tipičnoj CMOS 0,18um ili 0,35um tehnologiji za koju imamo podršku na FER-u. Ovaj projekt je važan jer unaprjeđuje analogne električne filtre, koji su kasnili u razvoju. Projekt također nudi mogućnost znanstvenog usavršavanja mladih znanstvenika u Hrvatskoj, jer su doktorski studenti i postdoktorski istraživači predviđeni kao suradnici na projektu.  Također je primjenjiv u industriji.]]></summary_hr><summary_en><![CDATA[The proposed project will explore new methods for design of continuous time analog filters of non-integer (fractional) order for analog interface in communication systems. Until now, such systems were of integer order, and in this project the generalization to the non-integer order will be done. In recent publications it has been proven that such methods are desirable, but in many applications, there are limitations due to the feasibility of fractional components that are not yet in commercial use. In addition to the problems in the production of fractional components there are unsolved mathematical problems such as sensitivity analysis, noise and stability of non-integer systems. In the integrated implementation these problems are especially observed (high sensitivity to components tolerances, instability due to parasitic components) and are calling for new, unconventional and creative techniques of realization. In particular we will focus our research on analog part of mixed electronic circuits, which is a part of the &#39;analog interface&#39; to the outside analog world. We will show that the application of the theory of electrical circuits and lines can achieve a variety of proposed improvements. Research in the beginning will be of integer order, and afterwards fractional for high flexibility and additional degree of design freedom. Using the theory of fractals we propose a new Bessel filter approximation. As a result of the project, with new theoretical achievements, two integrated circuits that are used for verification of the theory will be realized in a typical CMOS 0,18um or 0,35um technology for which we have the support of the FER. This project is important because it improves the analog electrical filters that were late in development. The project also offers the possibility of training young scientists in Croatia, because they are predicted as collaborators on this project as doctoral students and postdoctoral researchers. It is applicable for industry, too.]]></summary_en></project><project>
<id>7503</id><title_hr><![CDATA[Geokemija i zapis redoks indikatora u različitim uvjetima okoliša: prema boljem razumijevanju redoks uvjeta u prošlosti]]></title_hr><title_en><![CDATA[Geochemistry and redox proxie’s signature under the diverse environmental conditions: towards better understanding of the past redox]]></title_en><user_id>561</user_id><user_firstLast_name>Elvira Bura-Nakić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2018-01</proposal_call><code>IP-2018-01-7813</code><acronim><![CDATA[REDOX]]></acronim><duration>01.11.2018 - 31.10.2022</duration><status>Završio</status><financ_value>131.395,58 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Geologija, Kemija, </scie_field_hr><scie_field_en>Geology, Chemistry, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>23754, 12557, 989, 595, 28632, 864978, </team_members_id><team_members_names><![CDATA[Morten Andersen, Dario Omanović, Nevenka Mikac, Dijana Jadreško, Lucija Knežević, Igor Živković, ]]></team_members_names><keywords_hr><![CDATA[redoks prošlost, pokazatelj, izotopi, koncentracija, redoks vrste]]></keywords_hr><keywords_en><![CDATA[redox history, proxie&#39;s, isotopes, abundance, redox species]]></keywords_en><summary_hr><![CDATA[Rekonstrukcija kemijskog sastava atmosfere i oceana tijekom duge Zemljine geološke povijesti, kao i karakterizacija redoks uvjeta atmosfere i oceana, odnedavna privlači veliku pozornost. Oceanski sedimenti sadržavaju geokemijske zapise kroz veći dio Zemljine povijesti. Istraživanja su pokazala da faktor obogaćenja metala osjetljivih na redoks uvjete, kao i njihov izotopni sastav u (anoksičnim) sedimentima, nose važne informacije o redoks uvjetima u vremenu taloženja sedimenta. Ipak kako bi se u potpunosti iskoristile mogućnosti koje pružaju različiti pokazatelji za rekonstrukciju Zemljine redoks prošlosti obligatorno je temeljito razumijevanje ponašanja istih u suvremenim okolišima.Cilj REDOX-a je daljnja karakterizacija ponašanja prethodno istraživanih pokazatelja (Mo i U), te detaljno istraživanje relativno novih redoks pokazatelja kao što su V i Re. Kombinacija tih pokazatelja pružiti će poboljšani radni okvir nužan za što bolje tumačenje prošlih redoks uvjeta kao i za razdvajanje općih zapisa od zapisa uslijed procesa ograničenih unutar sedimenta.Istraživanja unutar projekta REDOX usmjerena su na:i.) unapređenje primjene skupne Mo-U koncentracije i izotopnih sastava kao redoks pokazatelja;ii.) razvijanje/implementacija specifičnih analitičkih postupaka za određivanje V redoks vrsta i Re izdvajanje i koncentriranje;iii.) definiranje procesa koji kontroliraju Re i V koncentraciju i mobilnost u sedimentu i vodenoj fazi u oksičnim, hipoksičnim i anoksičnim sredinama.Istraživanje unutar REDOX-a ima za cilj kombinirati specifične analitičke pristupe (kromatografsko određivanje V redoks vrsta, izolacija i koncentriranje Re), klasične analitičke tehnike (spektrofotometrija, MC-ICP-MS i elektrokemija) kao i specifičnosti jedinstvenih anoksičinih okoliša uz istočnu obalu Jadrana. Očekuje se da će istraživanja u okviru REDOX-a imati veliki utjecaj u području geokemije i izotopne geokemije metala osjetljivih na redoks (Mo, U, V i Re) unutar modernih i drevnih okruženja.]]></summary_hr><summary_en><![CDATA[Reconstructing the chemistry of past Earth’s atmosphere and ocean, and their redox states, has gained enormous attention recently. Ocean sediments provide geochemical records through much of Earth’s history. The enrichment of several redox-sensitive trace elements, as well as their isotopic composition in (anoxic) sediments have previously shown to carry important information about the prevailing redox conditions at the time of sediment deposition. Yet, to fully capitalize potential of these emerging redox proxies in reconstructing Earths’ past oxygenation state, a thorough understanding proxies geochemistry in modern environments is mandatory.   We aim to further characterise the redox chemistry on proxies which already have some maturity (Mo and U) as well targeting the newly emerging proxies such are V and Re. Combining these proxies will provide an improved framework for interpreting the specific past redox conditions and separate global ocean signatures from localised effects in the sediments. The research within project REDOX will target following subjects:i.) improve the usage of coupled Mo-U abundance and isotopic composition as redox proxy;ii.) development/implementation of specific analytical procedures for determining V redox speciation and Re concentration;iii.) determine the processes controlling Re and V abundance and mobility in sediments and overlying waters spanning oxic, hypoxic and anoxic conditions.The research within REDOX aims to combine particular analytical procedures (chromatographic redox V speciation, Re pre-concentration) with the several others classical analytical techniques (spectrophotometry, MC-ICP-MS and electrochemistry) and the unique study sites along the eastern Adriatic Coast. The research within REDOX is expected to have high impact in the field of environmental and isotope geochemistry, and will significantly contribute to our fundamental understanding of Mo, U, V and Re geochemistry within modern and ancient environments.]]></summary_en></project><project>
<id>7506</id><title_hr><![CDATA[Zaštitni mehanizmi i učinci flavonoida ugrađenih u nanonosače u modelnim membranama i neuronima]]></title_hr><title_en><![CDATA[]]></title_en><user_id>423</user_id><user_firstLast_name>Suzana Šegota</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-01</proposal_call><code>DOK-2018-01-8752</code><acronim><![CDATA[NanoFlavNeuroProtect]]></acronim><duration>01.09.2018 - 31.12.2022</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, </scie_field_hr><scie_field_en>Chemistry, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>25279</team_members_id><team_members_names><![CDATA[ Doktorand: Anja Sadžak ]]></team_members_names><keywords_hr><![CDATA[mikroskopija atomskih sila, modelne membrane, flavonoidi, nanočestice, neuroni, oksidativni stres, neurozaštita]]></keywords_hr><keywords_en><![CDATA[atomic force microscopy, model membranes, flavonoids, nanoparticles, neurons,  oxidative stress, neuroprotection]]></keywords_en><summary_hr><![CDATA[Flavonoidi, polifenolne biomolekule s antioksidativnom aktivnošću prepoznate su kao potencijalno novi terapeutici neurodegenerativnih bolesti. Osim što mehanizam antioksidativnog učinka flavonoida do danas nije u potpunosti razjašnjen, mogućnosti njihove terapeutske primjene smanjuje i slaba topljivost u vodi te kemijska nestabilnost pri fiziološkim uvjetima, koja se javlja prilikom primjene farmaceutskih proizvoda. Moguće rješenje je ugradnja flavonoida u nanočestice (NČ) kao nosače. Cilj predloženog projekta je riješiti problem slabe topljivosti u vodi i kemijske nestabilnosti dostavom flavonoida ugrađenih u NČ do modelnih membrana i neurona, čime bi se trebali poboljšati njihovi zaštitni učinci. Kako bi potvrdili primjenjivost ovog pristupa, u sklopu predloženog projekta istražit će se i interakcije između NČ i stanica, posebice membrana i NČ, jer su one od iznimne važnosti za unos u stanice i nanotoksičnost.Kao nano-nosači flavonoida koristit će se dvije vrste biorazgradivih mezoporoznih NČ, silike i getita. Mezoporozne magnetske Fe3O4 NČ su odabrane kao kontrolne NČ zbog dokazanih superiornih svojstava ugradnje i otpuštanja lijekova. Kombinacijom komplementarnih eksperimentalnih tehnika, koja do sada nije u potpunosti iskorištena u području nanobiotehnologije (mikroskopija atomskih sila, spektroskopija sila, infracrvena spektroskopija s oslabljenom totalnom refleksijom, dinamičko raspršenje svijetlosti, mikrokalorimetrija), predloženi projekt će u konačnici omogućiti detaljne informacije o utjecaju veličine, oblika, naboja i hidrofobnosti NČ s ugrađenim flavonoidima na modelne membrane i neurone, posebice u uvjetima oksidativnog stresa. Također, informacije o naboju te promjeni strukturnih i nanomehaničkih svojstava modelnih odnosno neuronskih membrana će omogućiti razvoj novih, poboljšanih terapeutika za neurološke poremećaje izazvane oksidativnim stresom.]]></summary_hr><summary_en><![CDATA[Flavonoids, polyphenolic biomolecules with antioxidative activity, have recently emerged as potential novel therapeutics for neurodegenerative diseases. In addition to the fact that the mechanisms of their antioxidant effects have not yet been fully elucidated, their applicability is rendered by poor water solubility and chemical instability under physiological conditions encountered during pharmaceutical product consumption. Flavonoid incorporation in nanoparticles (NPs) as carriers has been proposed as possible solution to surpass these obstacles. Therefore, the aim of the proposed project is to overcome the problem of poor water solubility and chemical instability of flavonoids by delivering them loaded in NPs to model membranes and neurons whereby their protective effects should be enhanced. In order to confirm usefulness of this approach, interactions between NPs and cells, in particular, membrane-NP interactions, will be determined since they are of crucial importance both for cell uptake and nanotoxicity.Two kinds of biodegradable mesoporous NPs, silica and goethite, will be investigated as flavonoid nanocarriers. Fe3O4 NPs were chosen as control due to their superior drug-loading and controlled release properties. By applying combination of complementary experimental techniques not yet fully exploited in the field of nanobiotechnology (atomic force microscopy, force spectroscopy, infrared spectroscopy with attenuated total reflection, dynamic light scattering, microcalorimetry), this project will ultimately generate detailed knowledge about the effects of the size, shape, charge and hydrophobicity of NPs loaded with flavonoids on model membranes and neurons, especially under oxidative stress conditions. In addition, information about the changes in structural and nanomechanical properties of model and neuronal membranes will pave the way towards development of novel and improved therapeutic solutions for oxidative stress-associated neurological disorders.]]></summary_en></project><project>
<id>7514</id><title_hr><![CDATA[Zdravstvene, kulturne i biološke odrednice dugovječnosti: antropološka studija preživljenja u dubokoj starosti]]></title_hr><title_en><![CDATA[Health, Cultural, and Biological Determinants of Longevity: Anthropological Perspective on Survival in Very Old Age]]></title_en><user_id>12597</user_id><user_firstLast_name>Tatjana Škarić-Jurić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2018-01</proposal_call><code>IP-2018-01-2497</code><acronim><![CDATA[HECUBA]]></acronim><duration>15.10.2018 - 01.03.2023</duration><status>Završio</status><financ_value>132.623,27 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo, Humanističke znanosti, Društvene znanosti, Prirodne znanosti, Biotehničke znanosti, </scie_area_hr><scie_area_en>Biomedicine and health sciences, Humanities, Social sciences, Natural sciences, Biotechnical sciences, </scie_area_en><scie_field_hr>Javno zdravstvo i zdravstvena zaštita, Biologija, Psihologija, Demografija, Etnologija i antropologija, </scie_field_hr><scie_field_en>Public health and health services, Biology, Psychology, Demography, Ethnology and anthropology, </scie_field_en><institution_hr><![CDATA[Institut za antropologiju]]></institution_hr><institution_en><![CDATA[Institute for Anthropological Research]]></institution_en><team_members_id>12594, 828, 23190, 13712, 23990, 23483, 23466, 4093, 29632, 28871, </team_members_id><team_members_names><![CDATA[Nina Smolej Narančić, Ana Perinić Lewis, Luka Bočkor, Jasminka Despot Lučanin, Spomenka Tomek-Roksandić, Tanja Ćorić, Hrvojka Marija Zeljko, Šime Smolić, Maja Šetinc, Željka Celinšćak, ]]></team_members_names><keywords_hr><![CDATA[starenje, dugovječnost, funkcionalna sposobnost, zdravlje, kultura, biologija]]></keywords_hr><keywords_en><![CDATA[ageing, longevity, functional ability, health, culture, biology]]></keywords_en><summary_hr><![CDATA[Osobe duboke starosti ogledan su primjer uspješnog starenja. Stoga je 2007. - 2009. provedeno antropološko istraživanje u zagrebačkim domovima za starije i nemoćne osobe u sklopu kojeg je za 300 osoba starih 85 i više godina prikupljen širok spektar podataka (anketni, biometrijski, DNA uzorci) koji čine polazište predloženog istraživanja. Protok vremena od 10 godina od inicijalnog istraživanja daje prvorazrednu mogućnost utvrđivanja dvaju ključnih ishoda: duljine života ispitanika (te izdvajanje poduzorka uistinu dugovječnih osoba) i duljine razdoblja njihove funkcionalne sposobnosti. Obje vrste ishoda predstavljaju krajnje točke prema kojima se mogu ocjenjivati sve mjerene značajke ispitanika te detektirati one koje obilježavaju uspješno starenje. Cilj je predloženog istraživanja da sveobuhvatno istraži utjecaj ne samo pojedinih bioloških odrednica i zdravstvenog stanja, već i socioekonomskih i psiholoških odlika kao i utjecaja osobne povijesti te čimbenika kulture (stavova, ponašanja, navika) na dinamiku procesa starenja. U sklopu projekta dodatno će se izvršiti genotipizacija „gena dugovječnosti“ i duljine telomera te regrutirati uzorak mladih odraslih osoba za komparativne genetičke analize. Utvrdit će se i učestalost rizičnih varijanti farmakogenetički relevantnih ADME gena koje mogu dovesti do štetnih djelovanja pri uzimanju pojedinih lijekova, što s obzirom na polipragmaziju prisutnu u ovoj dobnoj skupini predstavlja specifičan praktični doprinos projekta. Istraživanje povezanosti dvaju ključnih ishoda s biološkim, zdravstvenim i sociokulturnim obilježjima provest će multidisciplinarni tim stručnjaka iz različitih znanstvenih područja (medicina, biologija, antropologija, psihologija, ekonomija). Očekuje se da predloženo istraživanje fenomena dugovječnosti doprinese suvremenim teorijama starenja, ali i da ono urodi rezultatima koji bi mogli imati implikacije za gerontološku i gerijatrijsku praksu te za planiranje javnozdravstvenih i socijalnih politika u RH.]]></summary_hr><summary_en><![CDATA[Persons of very old age may be a particularly useful model for successful ageing. Within the extensive anthropological survey of 300 oldest old persons (85+ yrs) conducted in 2007/09 in retirement homes in Zagreb, a wide spectrum of data from face-to-face interviews, biometry and blood samples was collected that forms the basis for proposed research. The period of 10 years that elapsed since this initial study offers now a first class possibility to detect the two key outcomes: the examinees&#39; survival time (and selection of exceptionally long-lived subsample) and the duration of their preserved functional ability. Both outcomes represent the endpoints according to which all studied traits will be assessed in order to elucidate those that have a crucial role in successful ageing. While most studies have focused on particular aspects of human longevity, the proposed project aims at investigating comprehensively the impact of numerous biological and health-related features along with different socioeconomic and psychological traits as well as life history and cultural factors (attitudes, behavior, habits). Additional data will be generated through genotyping of „longevity genes“ and telomeres’ length in long-lived and in newly recruited comparative sample of young persons. Also, genotyping of the pharmacogenetically relevant ADME genes will be performed in order to determine the frequency of their risk variants for adverse reactions to drugs which is of high practical importance due to the existing polypragmasy in advanced age. To achieve the aims of the project, a multidisciplinary team of investigators from the fields of anthropology, medicine, biology, psychology and economy has been set up. The proposed investigation of successful ageing and longevity is expected to contribute to the current theories of ageing and to bring results relevant for gerontological and geriatric practice and for planning the public health and social policies in the Republic of Croatia.]]></summary_en></project><project>
<id>7515</id><title_hr><![CDATA[Analiza interakcija butirilkolinesteraze s novim inhibitorima i reaktivatorima ]]></title_hr><title_en><![CDATA[Analysis of Butyrylcholinesterase Interactions with Novel Inhibitors and Reactivators]]></title_en><user_id>872</user_id><user_firstLast_name>Zrinka Kovarik</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2018-01</proposal_call><code>IP-2018-01-7683</code><acronim><![CDATA[AnalyseBChE]]></acronim><duration>01.10.2018 - 30.09.2022</duration><status>Završio</status><financ_value>132.722,81 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, </scie_field_hr><scie_field_en>Chemistry, </scie_field_en><institution_hr><![CDATA[Institut za medicinska istraživanja i medicinu rada]]></institution_hr><institution_en><![CDATA[Institute for Medical Research and Occupational Health]]></institution_en><team_members_id>991, 411, 489, 3241, 982, 3033, 5926, 24011, 28637, 28972, 17747, </team_members_id><team_members_names><![CDATA[Anita Bosak, Nikolina  Maček Hrvat, Goran Šinko, Anamarija Knežević, Maja Katalinić, Suzana Žunec, ZORAN RADIC RADIC, Vesna Gabelica Marković, Tena Cadez Cadez, Ana Matošević, Tamara Zorbaz, ]]></team_members_names><keywords_hr><![CDATA[acetilkolinesteraza, butirilkolinesteraza, bojni otrovi, inačice, kinetika]]></keywords_hr><keywords_en><![CDATA[acetylcholinesterase, butyrylcholinesterase, bioscavengers, variants, nerve agents, kinetics]]></keywords_en><summary_hr><![CDATA[Inhibicija ljudske butirilkolinesteraze (BChE) vezanjem spojeva na katalitički serin ima iznimnu ulogu u detoksikaciji i zaštiti organizma od ksenobiotika kao što su organofosfati (OP) te u metabolizmu lijekova kao što su karbamat bambuterol i fenotiazin etopropazin. Međutim, unatoč ovoj važnoj ulozi BChE, proučavanje kinetike tog enzima uglavnom je vezano uz istraživanje srodnog enzima acetilkolinesteraze (AChE) ključne za prijenos živčanih impulsa. Štoviše, reaktivatori inhibirane BChE, kao i lijekovi koji se koriste za liječenje neurodegenerativnih bolesti, sintetizirani su empirijski prije razriješenja kristalne strukture enzima. Zbog specifičnosti aktivnog mjesta BChE afinitet enzima te inhibicija i brzina reaktivacije nisu do sada detaljno istražene. Isto tako naša istraživanja ukazuju da na brzinu reakcije reaktivacije značajno utječe dizajn eksperimenta te reakcije poput oksimolize i reverzibilne inhibicije, kao i adekvatna razrjeđenja u Ellmanovoj metodi potrebna za zaustavljanje ovih reakcija. Stoga je cilj ovog projekta detaljno istražiti mehanizme interakcija BChE i moguća ograničenja, koristeći cjelovitu analizu dosadašnjih spoznaja te istraživanjem interakcija BChE s poznatim i novim spojevima. Biokemijski mehanizam enzimskih interakcija proučavat će se na molekulskom nivou pomoću in silico, in vitro i ex vivo metoda. Kinetičke konstante ispitivanih reakcija odredit će se na temelju poznatih kinetičkih modela, dok će u slučaju ne standardne regresijse biti razvijeni novi kinetički modeli. Ove složene analize dat će uvid u strukturna svojstva koje neki spoj mora zadovoljiti kako bi ostvario produktivne interakcije s BChE čime će se stvoriti osnove za dizajn i sintezu reaktivatora fosfilirane BChE kao i potencijalnih lijekova za bolesti koje uključuju inhibiciju BChE. Stoga, rezultati ovog projekta će otvoriti nove perspektive, a njihov će utjecaj izaći iz okvira istraživanja kolinesteraza.]]></summary_hr><summary_en><![CDATA[The inhibition of butyrylcholinesterase (BChE) in human tissues by binding of compounds to its active site serine is important for the detoxification and scavenging of xenobiotics such as organophosphates (OP) as well as for the metabolism of pro-drugs and drugs such as the carbamate bambuterol and the phenothiazine ethopropazine. Despite of the importance of BChE, its kinetic reactions were investigated mostly as comparative studies on the related enzyme acetylcholinesterase (AChE), which has a vital function in cholinergic neurotransmission. Moreover, reactivators of inhibited BChE, as well as drugs for the treatment of neurodegenerative diseases were empirically synthesized before the BChE crystal structure was resolved. Due to specific structural requirements, its binding affinity, inhibition and reactivation rates have not been rigorously investigated. It is known from our recent analyses that reactivation rates are influenced by experimental design and assays need to account for side reactions – oximolysis, reversible inhibition, and adequate dilution of reactants. Therefore, this project utilizes known and new compounds to gain a better understanding of the mechanistic basis of cholinesterase family interactions and their limitations. The biochemical mechanism of enzyme interactions will be comprehensively studied on a molecular level with in silico, in vitro, and ex vivo methods. Kinetic constants of the studied interactions will be determined based on known kinetic models, while in need of unusual regression analysis new kinetic models will be developed. These comprehensive analyses will explain structural requirements for compounds interacting with BChE and gain a platform for synthesis of reactivators of inhibited BChE and potentially active drugs in disorders that involve BChE inhibition. Many of the findings that should arise from this project will impact the mechanisms of hydrolytic catalysis, extending beyond the field of cholinesterases.]]></summary_en></project><project>
<id>7516</id><title_hr><![CDATA[Makroekonomski učinci turizma]]></title_hr><title_en><![CDATA[Macroeconomic impact of tourism]]></title_en><user_id>2832</user_id><user_firstLast_name>Ivan Kožić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2018-01</proposal_call><code>IP-2018-01-2961</code><acronim><![CDATA[MACROTOUR]]></acronim><duration>01.12.2018 - 30.11.2022</duration><status>Završio</status><financ_value>7.536,27 eur</financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Ekonomija, </scie_field_hr><scie_field_en>Economy, </scie_field_en><institution_hr><![CDATA[Institut za turizam]]></institution_hr><institution_en><![CDATA[Institute for Tourism in Zagreb]]></institution_en><team_members_id>5218, 4385, 5245, 23294, </team_members_id><team_members_names><![CDATA[Ivan Sever, Petar Sorić, NEVEN IVANDIĆ, Velimir Šonje, ]]></team_members_names><keywords_hr><![CDATA[Makroekonomija, Turizam, BDP, Zaposlenost, Inflacija]]></keywords_hr><keywords_en><![CDATA[Macroeconomics, Tourism, GDP, Employment, Inflation]]></keywords_en><summary_hr><![CDATA[Turizam kao amalgam različitih industrija koje udružene služe zadovoljenju ljudske potrebe za razonodom i rekreacijom ima velik i raznolik i utjecaj na društva u suvremenom svijetu.Stoga je sveobuhvatni cilj ovog projekta sustavno istražiti makroekonomske učinke turizma, odnosno one njihove aspekte koji su još uvijek neadekvatno i nedovoljno istraženi. To podrazumijeva analizu triju makroekonomskih kanala putem kojih turizam utječe na gospodarstvo neke zemlje: (1) veza turizma i BDP-a, zatim (2) veza turizma i zaposlenosti te (3) veza turizma i inflacije.Iako je istraživanje veze turizma i BDP-a u postojećoj literaturi razmjerno izdašno dokumentirano, većina objavljenih radova isključivo je usmjerena na izračun turizmom generiranog BDP-a te ispitivanje veze između turizma i gospodarskog rasta. Prvi glavni cilj projekta je proširiti postojeće spoznaje istraživanjem utjecaja turizma na fluktuacije BDP-a te uz to istražiti u kojoj mjeri je veza turizma i gospodarskog rasta ovisna o društveno-političkom kontekstu.S druge strane mjerenje turizmom generirane zaposlenosti nije ni izdaleka tako opsežno istraženo kao mjerenje turizmom generiranog BDP-a. Stoga je drugi glavni cilj projekta ispitati kritične aspekte turizmom generirane zaposlenosti u slučaju malog, otvorenog gospodarstva poput hrvatskog, koje je u velikoj mjeri ovisno o turizmu te uz to istražiti i utjecaj turističke aktivnosti na cikličku (ne)zaposlenost.Treći glavni cilj projekta je istražiti turizmom inducirane inflatorne pritiske. Temeljna pitanja vezana uz dinamiku i trajanje turizmom inducirane inflacije u postojećoj literaturi još uvijek ostaju neodgovorena. Relevantnost projekta je dvostruka. Rezultati istraživanja bi s jedne strane trebali poslužiti kao sveobuhvatni okvir za daljnji razvoj područja makroekonomike turizma. Dok bi s druge strane mogli poslužiti kao empirijski doprinos budućim pokušajima modeliranja računalnog makroekonomskog modela hrvatskog gospodarstva.]]></summary_hr><summary_en><![CDATA[Tourism is an amalgam of different industries that together serve the human needs for leisure and recreation. As such, tourism is a socially important phenomenon that plays a significant transformative role in modern societies.The scope of this project is to explore the macroeconomic impact of tourism. It involves analysis of three channels through which tourism affects the economy: (1) the tourism-GDP nexus, (2) the tourism-employment nexus, and (3) the tourism-prices nexus.Although the issue of the tourism-GDP nexus is relatively well documented in the literature, most of the publications are focused on the calculation of the tourism-generated GDP and testing the tourism-led growth hypothesis. The first main objective of this project is to explore the impact of the activity of tourism on GDP fluctuation. Also to be explored is how tourism development impacts economic growth according to the political and social contexts.The measurement of employment generated by tourism has by no means been analyzed as plentifully as the measurement of tourism-generated GDP. Another main objective is to investigate the practical issues emerging from the measurement of tourism-generated employment in the case of a small tourism-driven economy. Also to be explored is how the activity of tourism impacts cyclical (un-)employment.The last main objective is to explore the inflationary pressure induced by tourism. The open questions regarding the tourism-prices nexus are related to the nature and dynamics of tourism-induced inflation. Is it a transitory or permanent phenomenon in a country like Croatia whose small open economy is heavily dependent on tourism?The relevance of the project is twofold. The written deliverables could serve as a comprehensive framework for further development of tourism macroeconomics. On the other hand, the research results could serve as empirical inputs in any future attempt at modelling a computable macroeconomic model of the Croatian economy.]]></summary_en></project><project>
<id>7519</id><title_hr><![CDATA[Studija važnosti spinskih međudjelovanja  kao osnova za nove pristupe u istraživanju materijala]]></title_hr><title_en><![CDATA[Elucidating the importance of spin-spin interactions as a tool for new approaches in ESR studies of materials]]></title_en><user_id>510</user_id><user_firstLast_name>Marina Ilakovac Kveder</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2018-01</proposal_call><code>IP-2018-01-3168</code><acronim><![CDATA[SPES]]></acronim><duration>01.11.2018 - 31.03.2023</duration><status>Završio</status><financ_value>137.932,68 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, Kemija, </scie_field_hr><scie_field_en>Physics, Chemistry, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>1213, 2647, 3280, 23120, 3545, 8238, 28786, 864926, </team_members_id><team_members_names><![CDATA[Dalibor Merunka, Dijana Žilić, Boris Rakvin, Senada Muratović, Srećko Valić, Miroslav Peric, Jakov Slade, Lucija Vujević, ]]></team_members_names><keywords_hr><![CDATA[dekoherencija spina elektrona, molekulski magneti,rotacijska i translacijska dinamika u tekućinama, ESR, HF-ESR]]></keywords_hr><keywords_en><![CDATA[electron spin decoherence, molecular magnets, rotational and translational dynamics in liquids, ESR, HF-ESR]]></keywords_en><summary_hr><![CDATA[Spin elektrona predstavlja osjetljivu lokalnu probu okoline u kojoj se nalazi te sudjeluje u jakim/slabim magnetskim spregama. Te se sprege mogu detaljno proučavati spektroskopijom elektronske spinske rezonancije (ESR). U okviru ovog projektnog prijedloga primijenit će se tehnička postignuća impulsne ESR instrumentacije te ESR spektrometara koji koriste visoke frekvencije/magnetska polja u svrhu dobivanja novih spoznaja o svojstvima promatranih materijala. Otvorena pitanja, koja su izabrana kao ciljevi istraživanja u ovom projektnom prijedlogu, su: a) kako kontrolirati dekoherenciju elektronskih spinova u krutini gdje odlučujući utjecaj ima dinamika mnoštva nuklearnih spinova. U središtu interesa ovog pitanja je hiperfina interakcija kao uzrok nuklearne spektralne difuzije. Sustavi u kojima dominira ovaj mehanizam raspada fazne memorije elektronskih spinova bit će izabrani kao prikladni eksperimentalni modelni sustavi. Primijenit će se različite tehnike dinamičkog razsprezanja u svrhu spoznaje kako se na fizičko stanje krute matrice (staklasto ili kristalinično) može zaključiti iz mjerenja vremena fazne memorije;b) kako opisati magnetska međudjelovanja i uređenje u kristalnoj strukturi molekulskog magneta (metalo-organske mreže, koordinacijski polimeri, kompleksi prijelaznih metala);c) kako dobiti informaciju o rotacijskoj i translacijskoj dinamici paramagnetskih molekula u tekućinama uzimajući u obzir sve efekte hiperfinog i dipolarnog međudjelovanja te međudjelovanja izmjene na pripadajuće ESR spektre.Te tri netrivijalne teme, koje uključuju proučavanje spinskih međudjelovanja elektrona u amorfnim i kristaliničnim materijalima te tekućinama, imaju za cilj proširenje granica koje imaju postojeći teorijski modeli. Također, očekivani cilj je i da se pravilnom manipulacijom i kontrolom spinskih stanja elektrona u ESR eksperimentu omogući dobivanje što više informacija iz spektralne analize, te, ako je moguće, utječe i na svojstva/dizajn materijala.]]></summary_hr><summary_en><![CDATA[Electron spin represents sensitive local probe of its environment and, thus, experiences strong/weak magnetic couplings. These can be thoroughly studied by electron spin resonance spectroscopy (ESR). In this context technical developments regarding pulsed/high magnetic field ESR spectrometers will be exploited in order to achieve new insight into the properties of the material under investigation. Therefore, within this project proposal several open questions are to be addressed: a) how to control the electron spin decoherence in a solid material when nuclear spin bath dynamics is a determining factor. Here, the hyperfine interaction in terms of nuclear spectral diffusion is in the focus of interest. Experimental model systems in which this channel of electron spin phase memory time decay is dominant will be purposely tailored; b) how to describe magnetic interactions in the crystal structure containing transition metal centres (metal-organic frameworks, coordination polymers);c) how to get information about rotational and translational dynamics of paramagnetic molecules in liquid systems by taking fully into account the effects of hyperfine, exchange, and dipolar interactions on their ESR spectra. These three non-trivial experimental tasks to be performed in amorphous, liquid and crystalline materials aim to extend the current limits of the existing theoretical models of electron spin-spin interactions. The expected goal is to extract as much as possible information from the ESR spectral analyses by proper manipulation of the electron spin states in an ESR experiment and possibly paw the way to influence the properties/design of materials. ]]></summary_en></project><project>
<id>7520</id><title_hr><![CDATA[Hiperfosforilacija, agregacija i transsinaptički prijenos tau proteina u Alzheimerovoj bolesti: analiza likvora i ispitivanje potencijalnih neuroprotektivnih spojeva]]></title_hr><title_en><![CDATA[]]></title_en><user_id>20884</user_id><user_firstLast_name>Mirta Boban</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-01</proposal_call><code>DOK-2018-01-9299</code><acronim><![CDATA[ALZTAUPROTECT]]></acronim><duration>01.10.2018 - 31.12.2022</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb School of Medicine]]></institution_en><team_members_id>25387</team_members_id><team_members_names><![CDATA[ Doktorand: Klara Zubčić ]]></team_members_names><keywords_hr><![CDATA[Alzheimerova bolest, cerebrospinalna tekućina (likvor), ELISA, neurofibrilarna degeneracija, neuroprotektivni spojevi, tau protein, tioflavin S ]]></keywords_hr><keywords_en><![CDATA[Alzheimer&#39;s disease, cerebrospinal fluid, ELISA, neurofibrillary degeneration, neuroprotective compounds, tau protein, thioflavine S]]></keywords_en><summary_hr><![CDATA[Za Alzheimerovu bolest (AB) ne postoji uzročno liječenje jer su brojni dosadašnji pokušaji intervencije temeljeni na amiloidnoj kaskadnoj hipotezi bili neuspješni. Usporedno s napretkom razumijevanja uloge tau proteina u patogenezi AB, metabolizam tau proteina je postao i važan terapijski cilj. Naime, smatra se da je u AB ravnoteža između kinaza i fosfataza tau proteina narušena, što dovodi do njegove hiperfosforilacije. Posljedično se povećava i frakcija tau proteina nevezanih za mikrotubule, pa se hiperfosforilirani tau monomeri vežu jedan za drugoga proizvodeći oligomere. Spajanje tau oligomera dovodi do oblikovanja sparenih uzvojitih filamenata, od kojih se sastoje sve neurofibrilarne promjene za koje je dokumentirano da predstavljaju najraniji neuropatološki događaj (tzv. &#39;&#39;pre-tangle&#39;&#39; stadij) od ključnog značaja za patogenezu AB. Ciljevi našeg projekta su: 1) bolje definirati odnos između bioloških biljega ranih stadija AB: ukupnih i fosforiliranih tau proteina, kao i amiloida ß u cerebrospinalnoj tekućini (likvoru) bolesnika s AD, MCI (blagi spoznajni poremećaj) i kontrolnih ispitanika. Uporabom inovativnog ELISA postupka i modificiranog eseja pomoću tioflavina S, u uzorcima likvora odrediti ćemo omjer između monomera i oligomera (agregata) tau proteina. Ti će novi podatci biti uspoređeni s kliničkim, neuropsihološkim i MRI nalazima; 2) testirati ćemo neke poznate i potencijalno neuroprotektivne spojeve (donepezil, klorgilin, nekoliko različitih flavonoida, te PF9601N i ASS234) na fosforilaciju tau proteina izazvanu okadaičnom kiselinom i nokodazolom u kulturama SH-SY5Y i P19 stanica. Epitope tau proteina fosforilirane na Thr181, Ser199 i Thr231 analizirati ćemo ELISA postupkom, a one na epitopima Thr202, Thr205, Ser396 i Ser404 pomoću westernske razložbe; i 3) istražiti ćemo biokemijski i imunocitokemijski transsinaptičko širenje neurofibrilarne degeneracije i razinu izraženosti tau mRNA nakon injekcije tau oligomera u entorinalnu moždanu koru miša.]]></summary_hr><summary_en><![CDATA[There is no effective treatment for Alzheimer’s disease (AD). As many drugs discovery attempts based on the amyloid cascade hypothesis have not been successful, tau protein has become an increasingly important therapeutic target owing to advances in understanding of its role in AD pathogenesis. In AD, the balance of tau kinase and phosphatase activity is shifted, creating a highly phosphorylated species of tau. This raises the fraction of unbound tau, which is no longer attached to microtubules, allowing for monomeric hyperphosphorylated tau to bind to one another to produce oligomers. Fusion of these oligomeric species leads to the formation of paired helical filaments, the primary constituent of neurofibrillary changes, which have been documented to be an early and pivotal event (so-called „pre-tangle“ stage) in the pathogenesis of AD. Our aims are: 1) to define better the relationship between the early AD biomarkers total and phospho-tau proteins, as well as amyloid ß in cerebrospinal fluid (CSF) of AD, MCI (mild cognitive impairment), and control subjects. By using innovative ELISA and modified thioflavin S binding assay on CSF samples, we will also assess the ratio between monomer and oligomer (aggregated) tau species. These new data will be correlated to clinical, neuropsychological, and MRI findings; 2) to test the effect of several known and potentially neuroprotective compounds (donepezil, clorgyline, several flavonoids, PF9601N and ASS234, among others) on tau phosphorylation induced by okadaic acid and nocodazole in SH-SY5Y and P19 cell cultures. Tau epitopes phosphorylated at Thr181, Ser199 and Thr231 residues will be analyzed by ELISA, while p-tau epitopes at Thr202, Thr205, Ser396 and Ser404 will be analyzed by Western blot; and 3) to investigate biochemically and immunocytochemically the trans-synaptic spreading of neurofibrillary degeneration and tau mRNA expression after the injection of tau oligomers in the mouse entorhinal cortex.]]></summary_en></project><project>
<id>7521</id><title_hr><![CDATA[Ekstrakcije bioaktivnih spojeva iz mediteranskog bilja sa “zelenim otapalima” primjenom visokonaponskog pražnjenja]]></title_hr><title_en><![CDATA[]]></title_en><user_id>469</user_id><user_firstLast_name>Anet Režek Jambrak</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-01</proposal_call><code>DOK-2018-01-8194</code><acronim><![CDATA[GREENVOLTEX]]></acronim><duration>01.10.2018 - 29.06.2024</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Prehrambena tehnologija, </scie_field_hr><scie_field_en>Food technology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prehrambeno-biotehnološki fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Food Technology and Biotechnology]]></institution_en><team_members_id>25273</team_members_id><team_members_names><![CDATA[ Doktorand: Marinela Nutrizio ]]></team_members_names><keywords_hr><![CDATA[visokonaponsko pražnjenje, plazma, ekstrakcije, zelena otapala, mediteransko bilje]]></keywords_hr><keywords_en><![CDATA[high voltage discharges, plasma, extraction, green solvents, mediteranean herbs]]></keywords_en><summary_hr><![CDATA[Prehrambena industrija intenzivno razvija ne-toplinske tehnike obrade hrane kao što su netoplinske plazme, pulsirajuće električno polje, visoki hidrostatski tlak te ultrazvuk visokog intenziteta. Nove netoplinske tehnike omogućavaju provedbu ekstrakcije bioaktivnih tvari bez primjene organskih otapala pri čemu se kao otapalo može koristiti voda ili neka tzv. “zelena otapala” npr. voda, D-limonen, dimetilkarbonat (DMC), etanol, etil-acetat i dr. Jedna od takvih obećavajućih tehnika je i visokonaponsko električno pražnjenje-plazma. Projektom će se nastojati ostvariti sljedeći ciljevi:C1 Razviti uređaj za generiranje plazme koji se sastoji od generatora plazme i reaktora s različitim konfiguracijama elektroda pri čemu će se koristiti inovativan pristup generiranja visokog napona DC napajanja pomoću moderne solid state tehnologije. C2 Utvrditi će se učinkovitost ekstrakcije bioaktivnih komponenti i eteričnih ulja iz autohtonog mediteranskog bilja (list masline, ružmarin, kadulja, mravinac, timijan, majčina dušica) plazmom uz upotrebu vode i „zelenih„ otapala. C3 Optimizirati će se djelovanje inovativnog uređaja za generiranje plazme tijekom ekstrakcija kako bi dobili što veće iskorištenje postupka.C4 Utvrditi će se biološka aktivnost dobivenih ekstrakata putem analitičkih metoda, te ispitati mogućnost nastajanja eventualnih oksidativnih promjena tijekom postupaka ekstrakcija. C5  Dobiveni ekstrakti će se na odgovarajući način izolirati te stabilizirati primjenom postupaka liofilizacije i/ili inkapsulacije.Predloženo istraživanje doprinijeti će području istraživanja, na način da će biti konstruiran inovativni uređaj za produkciju plazme direktno u tekućinama kojim će se moći provesti brza i učinkovita ekstrakcija bioaktivnih komponenata i eteričnog ulja iz autohtonog mediteranskog bilja. Novom netoplinskom tehnikom ekstrakcije nastojat će se smanjiti vrijeme ekstrakcije, upotreba otapala, onečišćenje okoliša i ukupan energetski utrošak uz istovjetno iskorištenje.]]></summary_hr><summary_en><![CDATA[The food industry is rapidly developing new non-thermal food processing techniques like non-thermal plasma, pulsed electric field, high hydrostatic pressure and high intensity ultrasound. New non-thermal techniques are considered “green” extraction methods for isolation of bioactive compounds, because conventionally used organic solvents for extraction can be replaced by water or other green solvents like D-limonen, dimethylcarbonate (DMC), ethanol, ethyl-acetate etc. High voltage electrical discharge-plasma (HVED) is one of new promising green techniques. The aims of this project will be accomplished and they include:O1 Design and development an equipment for generating plasma which consists of: plasma generator and reactor with different configuration of electrodes. During designing of plasma generator, new innovative approach for generating high voltage DC supply by usage of modern solid state technology will be applied.O2 To established effectiveness of extraction of bioactive compounds and volatile oils from autochthonous Mediterranean herbs (olive leaf, rosemary, sage, oregano, thyme, wild thyme), with plasma by usage of water and green solvents O3 To increase yield of process by optimisation of the operation mode of innovative equipment for generating plasma.O4 Biological activity of obtained extracts will be determined by analytical methods, and investigated the possibility of oxidative changes during extraction processO5 Obtained extracts will be isolated and stabilized by lyophilization and/or encapsulation. This Project proposal will contribute to the research area by constructing a new innovative equipment for liquid plasma which will be useful for quick and efficient extraction of bioactive compounds and volatile oils from leaves of autochthonous Mediterranean herbs. By new, non-thermal extraction technique, the attempt is to reduce duration of extraction, solvent usage, environment pollution and total energy consumption.]]></summary_en></project><project>
<id>7523</id><title_hr><![CDATA[Nove Strategije Za Pripravu Tetrasupstituiranih Kiralnih Centara: Asimetrične Katalitičke Reakcije Usmjerene Protuanionom]]></title_hr><title_en><![CDATA[New Strategies for the Synthesis of Tetrasubstituted Chiral Centers: Asymmetric Counteranion-Directed Catalysis]]></title_en><user_id>558</user_id><user_firstLast_name>Matija Gredičak</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2018-01</proposal_call><code>IP-2018-01-4053</code><acronim><![CDATA[NSYNC-ACDC]]></acronim><duration>01.10.2018 - 31.12.2022</duration><status>Završio</status><financ_value>132.284,82 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, </scie_field_hr><scie_field_en>Chemistry, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>22528, 23628, 23654, 27441, 855382, 25282, </team_members_id><team_members_names><![CDATA[Danijel Glavač, Shu-Li You, Chao Zheng, Arben Beriša, Nikola Topolovcan, Mateja Matišić, ]]></team_members_names><keywords_hr><![CDATA[ACDC, organska sinteza, asimetrična organokataliza, kiralne Bronstedove kiseline, tetrasupstituirani kiralni centri]]></keywords_hr><keywords_en><![CDATA[ACDC, organic synthesis, asymmetric organocatalysis, chiral Bronsted acids, tetrasubstituted chiral centers]]></keywords_en><summary_hr><![CDATA[Jedan od primarnih zadataka sintetske organske kemije je razvoj kemijskih reakcija koje na kontrolirani način selektivno omogućuju molekulsku raznolikost. Stoga je od velikog značaja razvoj novih metoda za visoko selektivne i specifične priprave složenih spojeva. Prilikom razvoja takvih metoda, jedan od najvećih izazova kemičarima predstavlja priprava kiralnih tetrasupstituiranih stereogenih centara. Iako je moderna sintetska kemija opremila kemičare nizom metoda za savladavanje najsloženijih sintetskih problema, takvi su protokoli često skupi i vremenski zahtjevni. S druge strane, Priroda takve procese obavlja s lakoćom upotrebom enzima – složenih strojeva usavršavanih milijunima godina evolucije. Cilj ovog projekta je razvoj istraživačkog programa za oponašanje Prirode i enzima korištenjem asimetričnih organokatalitičkih reakcija, s ciljem kontroliranja selektivnog i specifičnog nastajanja složenih struktura koji u sebi sadrže tetrasupstituirane stereogene centre kao aktivne strukturne podjedinice.Nastajanje novih kemijskih veza temeljit će se na strategiji ionskih parova, konceptu koji je već primjenjen u seriji asimetričnih transformacija, no koji je ograničen relativno niskom aktivacijom početnih spojeva. Kako bi se omogućila aktivacija takvih sustava, projektom se predlaže proširenje koncepta ionskih parova na asimetrične katalitičke reakcije usmjerene protuanionom (eng. asymmetric counteranion-directed catalysis, ACDC). Na taj bi se način omogućila priprava složenih strukturnih kostura koji se trenutno mogu dobiti isključivo primjenom zahtjevnih, skupih i nepraktičnih protokola. Projektom se predviđa razvoj asimetričnih metoda za pripravu tetrasupstituiranih stereogenih centara korištenjem ACDC strategije, s posljedičnim ciljem razvoja učinkovitije katalize nekovalentnim interakcijama. Projekt pruža mogućnost za istraživanje i primjenu čitavog niza katalitičkih asimetričnih organskih reakcija za koje trenutno ne postoji presedan.     ]]></summary_hr><summary_en><![CDATA[One of the primary goals of synthetic organic chemistry is the development of chemical reactions that selectively introduce molecular diversity in a controlled manner. In this regard, the development of novel methods for highly selective and specific syntheses of complex materials is of great importance. In the development of these novel methods, one of the biggest challenges presented to chemists is the construction of tetrasubstituted stereogenic centers. Although modern chemistry offers access to a plethora of tools to tackle the most complex total syntheses, these processes are expensive and time consuming. On the other hand, Nature effortlessly performs these tasks by employing enzymes – complex machines perfected through millions of years of evolution.In this proposal, we aim to emulate Nature through asymmetric catalysis in order to develop selective and specific protocols for the construction of complex materials comprising tetrasubstituted stereogenic centres as active structural subunits. We plan to base our new strategic bond forming reactions on ion pairing strategy. This principle has already been exploited in the range of elegant selective asymmetric transformations, but can be limited by relatively low levels of activation offered by these materials. In order to achieve activation of such systems, we plan to extend the principle of ion–binding in catalysis by employing asymmetric counteranion–directed catalysis (ACDC). This is an important task as it will allow formation of demandingstructural motifs that are currently difficult to produce. This proposal aims to develop transformations for the generation of complex materials with chiral tetrasubstituted centers by employing ACDC strategies, and lead to the development of more efficient catalyst systems that operate through non–covalent interactions. The project offers a rare opportunity to investigate and exploit an entire manifold of unprecedented catalytic asymmetric organic reactions.]]></summary_en></project><project>
<id>7531</id><title_hr><![CDATA[Reprogramiranje homeostaze i regeneracije kože uporabom nove tehnike mikro-transplantacije stanica]]></title_hr><title_en><![CDATA[Reprogramming of skin homeostasis and regeneration using a novel cell micro-transplantation technology]]></title_en><user_id>1396</user_id><user_firstLast_name>Ivica Rubelj</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2018-01</proposal_call><code>IP-2018-01-8654</code><acronim><![CDATA[REPROSKIN]]></acronim><duration>17.12.2018 - 23.04.2023</duration><status>Završio</status><financ_value>132.059,19 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>19039, 3333, 570, 6719, 23714, 23744, 27530, 1137, </team_members_id><team_members_names><![CDATA[Lucia Nanić, Marija Mary Sopta, Miljenko Huzak, Sanja Davidović-Mrsić, Michael Bader, Florian Gruber, Andrea Cedilak, Vladimir Farkaš, ]]></team_members_names><keywords_hr><![CDATA[starenje, regeneracija, starenje kože, mikro-transplantacija, tkivna homeostaza, SASP]]></keywords_hr><keywords_en><![CDATA[aging, regeneration, skin aging, micro-transplantation, tissue homeostasis, SASP]]></keywords_en><summary_hr><![CDATA[Nakupljanje starih stanica u tkivima je glavni katalizator starenja kod ljudi. Stare stanice imaju promijenjenu ekspresiju gena, karakteriziranu porastom sekrecije citokina, kemokina i ekstracelularnih proteinaza, poznatih kao senescence-associated secretory phenotype (SASP). SASP negativno utječe na homeostazu kože i epidermalne matične stanice (ESC). Ekspresija enzima telomeraze sprječava starenje stanica i održava njihov mladi fenotip. U ovom projektu ćemo istražiti mogučnost za regeneraciju i pomlađivanje kože pomoću tehnike mikrotransplantacije stanica. Analizirat ćemo promjene u koži nakon povečanja udjela mladih ili pomlađenih zdravih stanica na modelu štakora te na modelu ljudskih organotipskih epidermalnih kultura. To će se postići značajnim povečanjem postotka (> 35%, do 55%) mladih stanica ili telomerazom revitaliziranih stanica u koži. Očekujemo da će doći do povećanja regenerativne sposobnosti dermisa i epidermisa, kao i povećanja aktivnosti epidermalnih matičnih stanica. Osim starenja, različiti genetski poremećaji mogu poremetiti zaštitnu funkciju kože. Među najtežim takvim poremećajima je Epidermoliza bullosa (EB). EB je heterogena skupina nasljednih poremećaja kože uzrokovanih mutacijama u 18 različitih gena važnih za dermalno-epidermalne veze, među kojima je i kolagen VII (C7) koji učvršćuje bazalnu membranu. Štakori koji nose takve mutacije imaju krhku kožu sklonu guljenju koja ujedno pokazuje sve glavne karakteristike EB kod ljudi. Stoga ćemo također analizirati promjene u koži EB štakora nakon povećanja udjela stanica koje nose divlji tip C7. Do sada smo uspostavili protokol za mikrotransplantaciju stanica u tkivo kože koji nam omogućuje manipulaciju raznim staničnim tipovima. Glavni cilj ovog projekta je izravno pokazati da je moguće mijenjati stanični sastav kože i time utjecati na metabolički profil lokalnog tkiva, poboljšati aktivnost matičnih stanica in vivo te time povećati regeneraciju kože.]]></summary_hr><summary_en><![CDATA[Accumulation of senescent cells in tissues is the main catalyst of aging in humans. Old cells have altered gene expression, highlighted by a strong increase in secreted cytokines, chemokines and extracellular proteinases known as the senescence-associated secretory phenotype (SASP) which has a negative impact on skin and epidermal stem cells (ESC). Expression of the enzyme telomerase prevents cell aging and maintains their young phenotype. In this project we will explore the potential for skin regeneration and rejuvenation by using a cell micro-seeding technique. We will analyse changes in the skin following an increase in proportion of young or rejuvenated healthy cells in a rat skin model and in human organotypic epidermal equivalent model. This will be achieved by introducing a large proportion (>35%, up to 55%) of young cells or telomerase revitalized cells into skin. We expect to observe increase in regenerative capacity of dermis and epidermis as well as increase in ESC viability. Besides aging, various genetic disorders can disrupt protective function of the skin. Among most severe of such disorders is Epidermolysis bullosa (EB). EB is a heterogeneous group of hereditary skin fragility disorders caused by mutations in 18 different genes important for dermal-epidermal connections, among which is Collagen VII (C7) that anchor the basal membrane. Affected animals have fragile and blister-prone skin showing all major signs of EB in humans. Therefore we will also analyse changes in the EB rat skin following an increase in proportion of cells carrying wild type C7. So far we have established a protocol for micro-transplantation of cells into skin tissue which allows for manipulation of various cell populations. The main objective of this project is to directly show that it is possible to alter the cellular composition of tissues and with that alter the local tissue metabolic profile, improve viability of ESC in vivo and increase skin healing and regeneration.]]></summary_en></project><project>
<id>7538</id><title_hr><![CDATA[Hlađenje atoma frekventnim češljem]]></title_hr><title_en><![CDATA[Frequency comb cooling of atoms]]></title_en><user_id>5029</user_id><user_firstLast_name>Damir Aumiler</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2018-01</proposal_call><code>IP-2018-01-9047</code><acronim><![CDATA[CoolComb]]></acronim><duration>01.11.2018 - 31.07.2023</duration><status>Završio</status><financ_value>132.722,81 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, </scie_field_hr><scie_field_en>Physics, </scie_field_en><institution_hr><![CDATA[Institut za fiziku]]></institution_hr><institution_en><![CDATA[Institute of Physics in Zagreb]]></institution_en><team_members_id>23782, 23999, 23973, 22599, 28963, </team_members_id><team_members_names><![CDATA[Bojan Resan, Danijel Buhin, Wesley Campbell, Neven Šantić, Vjekoslav Vulić, ]]></team_members_names><keywords_hr><![CDATA[lasersko hlađenje, hladni atomi, optički frekventni češalj, rubidij, magneto-optička stupica]]></keywords_hr><keywords_en><![CDATA[laser cooling, cold atoms, optical frequency comb, rubidium, magneto-optical trap]]></keywords_en><summary_hr><![CDATA[Uvođenje laserskog hlađenja u atomsku i molekulsku fiziku prije tri desetljeća započelo je revoluciju koja nastavlja redefinirati krajolik eksperimenata koji nam pomažu bolje razumijeti kvantni svijet. Korištenje uskopojasnih kontinuiranih lasera za kontrolu temperature atoma evoluiralo je tijekom godina te postiglo puno šire područje primjene nego što je prvobitno bilo predviđeno, brzo pomičući granice znanstvenog razvoja kroz impresivne pothvate u području ultrahladnih atoma. Ipak, unatoč značajnim napretcima, preostaju važne praznine unutar područja, a jedna od najizraženijih je naša nemogućnost da laserski hladimo i zarobljavamo vodik, (gotovo sve) molekule te najrasprostranjenije atome organske kemije: ugljik, kisik i dušik.Cilj ovog projekta je stvoriti alate koji će nam omogućiti širenje primjene laserskog hlađenja na raznolike vrste atoma i molekula. Konkretno, koristit ćemo optički frekventni češalj za izravno lasersko hlađenje i zarobljavanje atoma rubidija (Rb) te demonstrirati istodobno hlađenje dva Rb izotopa. Kako bi postigli taj cilj, okupili smo iskusan tim istraživača - stručnjake za lasersku fiziku, hladne atome, spektroskopiju frekventnim češljem te teorijsko modeliranje međudjelovanja lasera i atoma - koji će (i) teorijski modelirati radijativnu silu na atome uzrokovanu frekventnim češljem i odrediti optimalne parametre češlja za hlađenje, (ii) dizajnirati i izgraditi novi pikosekundni Ti:safir laser sa spregnutim modovima pumpan plavim diodama, (iii) stabilizirati i postići kontrolu nad spektrom frekventnog češlja lasera te (iv) primijeniti frekventni češalj za izravno hlađenje i zarobljavanje Rb atoma i istodobno hlađenje dvije vrste atoma.Naša uspješna demonstracija potvrdit će frekventni češalj kao novi alat za lasersko hlađenje šireg raspona molekula i atoma koje do sada nije bilo moguće hladiti, omogučujući tako napredak u područjima kao što su kontrolirana kemija, astrofizika, precizna mjerenja te kvantne informacije i simulacije.]]></summary_hr><summary_en><![CDATA[The introduction of laser cooling to atomic and molecular physics three decades ago started a revolution that continues to redefine the landscape of feasible experiments which help us better understand the quantum world. The use of narrow-band continuous-wave lasers to control the motional temperature of atoms has evolved over the years to have much broader applications than originally anticipated, rapidly pushing forward the frontiers of scientific development through impressive efforts in the field of ultracold atoms. Yet despite these substantial advances, there remain important gaps in the field, one of the most conspicuous being our inability to laser cool and trap hydrogen, (almost any) molecules, or the most prevalent atoms in organic chemistry: carbon, oxygen, and nitrogen.The aim of this project is to create the tools that will allow us to extend laser cooling to more diverse species of atoms and molecules. Specifically, we will use an optical frequency comb for direct laser cooling and trapping of rubidium (Rb) atoms, and demonstrate simultaneous comb cooling of two Rb isotopes. To achieve this goal, we have gathered an experienced team of researchers – experts in laser physics, cold atoms, frequency comb spectroscopy, and theoretical modeling of laser-atom interactions – who will (i) theoretically model the comb-induced radiative force on atoms and define optimal comb parameters for cooling, (ii) design and build a novel blue-diode-pumped Ti:sapphire picosecond mode-locked laser, (iii) stabilize and gain control over its frequency comb spectrum, and (iv) apply the comb for direct cooling and trapping of Rb atoms and simultaneous dual-species cooling.Our successful demonstration will validate the frequency comb as a new tool for laser cooling a broader range of molecules and so far un-coolable species thus allowing breakthroughs in fields as diverse as controlled chemistry, astrophysics, precision measurements, and quantum information and simulation.]]></summary_en></project><project>
<id>7539</id><title_hr><![CDATA[Novi biomarkeri kronične bolesti presatka protiv primatelja]]></title_hr><title_en><![CDATA[]]></title_en><user_id>19447</user_id><user_firstLast_name>Dražen Pulanić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-01</proposal_call><code>DOK-2018-01-5291</code><acronim><![CDATA[Bio-cGVHD]]></acronim><duration>01.10.2018 - 16.02.2020</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Kliničke medicinske znanosti, </scie_field_hr><scie_field_en>Clinical sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb School of Medicine]]></institution_en><team_members_id>25382</team_members_id><team_members_names><![CDATA[ Doktorand: Antonela Samardžić ]]></team_members_names><keywords_hr><![CDATA[kronična bolest presatka protiv primatelja, biomarkeri, alogena transplantacija krvotvornih matičnih stanica, vWF, faktor VIII, glikani, imunologija]]></keywords_hr><keywords_en><![CDATA[chronic Graft-versus-Host disease, biomarkers, allogeneic hematopoietic stem cell transplantation, vWF, factor VIII, glycans, immunology]]></keywords_en><summary_hr><![CDATA[Kronična bolest presatka protiv primatelja (eng. chronic Graft-versus-Host disease, cGVHD) je multiorganska aloimuna i autoimuna bolest koja je najvažnija kasna komplikacija nakon alogenične presadbe krvotvornih matičnih stanica (aloPKMS) i vodeći uzrok ne-relapsnog morbiditeta i smrtnosti nakon aloPKMS. Zapažena incidencija bolesti kreće se između 30-70% nakon aloPKMS i povećava se zbog sve manjeg peritransplantacijskog mortaliteta, starije dobi transplantiranih bolesnika, češće upotrebe perifernih krvotvornih matičnih stanica i sve većeg broja transplantacija od nesrodnog davatelja. Bolest je kompleksna i obično zahvaća više različitih organskih sustava (kožu, oči, usta, jetru, gastrointestinalni sustav, pluća, muskuloskeletni sustav i genitourinarni sistem), a često se prezentira manifestacijama koje nalikuju na promjene u autoimunosnih bolesti. Nužno je pronalaženje prediktivnih i dijagnostičkih biomarkera koji bi koristili u procjeni rizika nastanka, dijagnoze i praćenja, procjene ativnosti i ishoda kroničnog GVHD. U Kliničkom bolničkom centru Zagreb 2013. godine osnovan je multidisciplinarni tim stručnjaka za cGVHD po uzoru na onaj formiran na National Institutes of Health (NIH, Bethesda, SAD). Osim što doprinosi poboljšanju skrbi za cGVHD pacijente, ovaj tim omogućuje preciznu interdisciplinarnu kliničku i laboratorijsku evaluaciju bolesti, prikupljanje bioloških uzoraka te nudi veliki potencijal za ispitivanje biomarkera ove teške i potencijalno smrtonosne kasne komplikacije nakon aloPKMS.Cilj ovog novog četverogodišnjeg projekta je prospektivnim longitudinalnim istraživanjem ispitati moguće nove biomarkere kroničnog GVHD (analizu glikana, faktora koagulacije, laboratorijskih parametara upale, B limfocita i monocita) uz detaljno kliničko multidisciplinarno evaluiranje bolesnika korištenjem suvremenih NIH standarda za cGVHD. ]]></summary_hr><summary_en><![CDATA[Chronic graft-versus-host disease (cGVHD) is a multi-organ alloimmune and autoimmune disorder and the most important late complication after allogeneic hematopoietic stem cell transplantation (alloHSCT). It is the major cause of non-relapse morbidity and mortality after alloHSCT. Reported incidence rates of cGVHD range from 30-70% of patients after alloHSCT, and are increasing due to lower peritransplant mortality, older recipients, the more frequent use of peripheral blood graft, and more unrelated donors. It is a complex and multisystem disease, affecting skin, eyes, mouth, liver, gastrointestinal tract, lungs,  muscular-skeletal system, and genital tract, often resembling manifestations of various autoimmune diseases. Predictive and diagnostic biomarkers of cGVHD are much needed to predict its onset, diagnose and monitor the disease, prognoses its course and outcome, and characterize its activity. At the University Hospital Center Zagreb a multidisciplinary team for cGVHD was formed in 2013 according to the team from the National Institutes of Health (NIH, Bethesda, USA).  This approach improved care of patients with cGVHD, but also provides interdisciplinary clinical and laboratory evaluation of this disease, collection of biologic samples with great potential for investigation of biomarkers of this complex and potentially lethal late complication after alloHSTC. The goal of this 4-year project is to study possible new biomarkers of cGVHD (glycan analysis, coagulation factors, laboratory markers of inflammation, B lymphocytes and monocytes) in a prospective longitudinal assessment of cGVHD patients, with their detail multidisciplinary evaluations using modern NIH standards for cGVHD.]]></summary_en></project><project>
<id>7543</id><title_hr><![CDATA[Kronične upalne bolesti crijeva u djece: incidencija, tijek bolesti te uloga prehrane i crijevne mikroflore u etiopatogenezi]]></title_hr><title_en><![CDATA[]]></title_en><user_id>5694</user_id><user_firstLast_name>Sanja Kolaček</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-01</proposal_call><code>DOK-2018-01-1181</code><acronim><![CDATA[PED-IBD]]></acronim><duration>23.07.2018 - 22.07.2022</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Kliničke medicinske znanosti, </scie_field_hr><scie_field_en>Clinical sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb School of Medicine]]></institution_en><team_members_id>25201</team_members_id><team_members_names><![CDATA[ Doktorand: Ivana Trivić ]]></team_members_names><keywords_hr><![CDATA[upalne bolesti crijeva, djeca, crijevna flora, enteralna prehrana, incidencija, registar]]></keywords_hr><keywords_en><![CDATA[inflammatory bowel disease, children, enteral nutrition, incidence, registry]]></keywords_en><summary_hr><![CDATA[Etiologija i patogeneza kroničnih upalnih bolesti crijeva (IBD - inflammatory bowel disease), unatoč visokoj prevalenciji, nisu razjašnjene. Predloženi mehanizam uključuje interakciju neodgovarajućeg (aberantnog) imunološkog odgovora na crijevnu mikrofloru / crijevni sadržaj, u genetski predisponiranih osoba. Cilj je ovog istraživačkog projekta pridonijeti rasvjetljavanju navedene patogeneze.Ciljevi. 1. Prehrana. Bolesnici s IBD-om vrlo često izbjegavaju određene namirnice u prehrani, pridajući im – po njihovu bolest – neželjena svojstva. Međutim, učinak takvih samonametnutih dijeta nije do sada istražen i za takve dijetetske postupke zasad nema znanstveno utemeljnog opravdanja. Od posebne je to važnosti za djecu u koje ozbiljnije dijetetske restrikcije mogu imati dugoročne posljedice na rast i razvitak. Stoga je prvi cilj ovog projekta utvrditi učestalost samoiniciranih dijeta u djece s IBD-om i procijeniti njihov učinak na: a) nutritivni status koristeći strogo definirane parametre, b) tijek bolesti. U istraživanje će se uključiti novodijagnosticirani bolesnici s IBD-om te zdrave kontrole.2. Crijevna mikroflora. Znanstveno je potvrđena terapijska učinkovitost isključive enteralne prehrane (EEN - exclusive enteral nutrition) na aktivnu formu Crohnove bolesti (CD) u djece, koja se, dijelom, pripisuje utjecaju na crijevnu mikrofloru. Međutim, dokaza o njihovoj povezanosti zasad nema. Stoga je drugi cilj ovog istraživanja utvrditi razliku u crijevnoj mikroflori u trenutku postavljanja dijagnoze i nakon indukcije remisije sa EEN. Crijevna mikroflora bolesnika usporedit će se s crijevnom mikroflorom zdravog brata ili sestre oboljelog djeteta i to neposredno prije, i dva dana nakon početka EEN. Nadalje, u djece s CD crijevna će se mikroflora odrediti i nakon završetka EEN te svakih dva mjeseca tijekom cijele prve godine praćenja. 3. PED-IBD registar. Do sada nije utvrđena incidencija, tijek i ishod bolesti („natural history“) u djece oboljele od IBD-a u Republici Hrvatskoj. Slijedom navedenoga, treći je cilj našeg projekta utemeljiti nacionalni registar djece s IBD-om s on-line bazom podataka koja će sadržavati sve važne kliničke i dijagnostičke parametre u sve djece s novodijagnosticiranom bolesti u Hrvatskoj. Podaci o bolesniku unositi će se kod dijagnoze i nakon godine dana praćenja. Za određivanje rizičnih čimbenika za nastanak relapsa koristit će se multivarijatna analiza koja će uključiti kliničke i terapijske parametre. ]]></summary_hr><summary_en><![CDATA[The etiology and pathogenesis of inflammatory bowel disease (IBD) have not been fully elucidated. 1. Diet. Patients with IBD, despite the absence of scientific evidence, often avoid certain types of food; however the effect of those self-imposed diets has not been determined. This is especially important in children whereby insufficient diet could have long-term consequences on growth and development. Therefore, the first objective of our study is to determine the frequency of self-induced diets in children with IBD and their impact on: a) nutritional status by using clearly defined parameters and b) course of the disease. The study will include newly diagnosed patients with IBD and healthy controls. 2. Intestinal microflora. It has been hypothesized that the excellent therapeutic effect of exclusive enteral nutrition (EEN) on pediatric active Crohn&#39;s disease (CD) could be explained by the effect on intestinal microflora. However, well performed studies are lacking. Therefore, the second objective of our study is to determine the difference in gut microflora at diagnosis and after remission induction achieved with EEN. Patients’ intestinal microflora will be compared with the microflora of healthy siblings before and two days after both groups receive EEN. Furthermore, in children with CD the intestinal microflora will be determined after 6 weeks of EEN and during the first year of follow up.  3. PED-IBD Registry. The incidence and natural history of pediatric IBD in Croatia has not been determined yet. The third goal of our project is to establish a national registry of children with IBD by providing an on-line database that will contain relevant clinical and diagnostic factors on all newly diagnosed pediatric IBD patients. To achieve this goal data will be entered at diagnosis and after one year of follow up. Multivariate analysis, which will include clinical and therapeutic parameters, will be used to determine risk factors for early disease relapse.]]></summary_en></project><project>
<id>7544</id><title_hr><![CDATA[Utjecaj akvakulture na prirodne morske populacije]]></title_hr><title_en><![CDATA[]]></title_en><user_id>3217</user_id><user_firstLast_name>Tanja Šegvić Bubić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-01</proposal_call><code>DOK-2018-01-1940</code><acronim><![CDATA[AquaPop]]></acronim><duration>01.08.2018 - 30.04.2022</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Poljoprivreda, </scie_field_hr><scie_field_en>Agriculture, </scie_field_en><institution_hr><![CDATA[Institut za oceanografiju i ribarstvo]]></institution_hr><institution_en><![CDATA[Institute of Oceanography and Fisheries]]></institution_en><team_members_id>21299</team_members_id><team_members_names><![CDATA[ Doktorand: Igor Talijančić ]]></team_members_names><keywords_hr><![CDATA[Akvakultura, utjecaj, prirodne populacije riba i školjkaša, ekološke zamke, prebjezi, genetske interakcije]]></keywords_hr><keywords_en><![CDATA[Aquaculture, Impact, Wild fish and shellfish populations, ecological traps, escapees, genetic interactions]]></keywords_en><summary_hr><![CDATA[Zbog stalnog rasta broja lokacija za uzgoj morskih organizama javlja se sveprisutna zabrinutost da marikultura kao gospodarska djelatnost može predstavljati opasnost za morsku biološku raznolikost kroz negativni utjecaj na prirodne populacije morskih organizama kao i cjelokupni morski ekosustav. Ekološke interakcije se odražavaju kroz činjenicu da kavezne uzgojne instalacije postaju nove ekološke niše za prirodne populacije ribe kod kojih promjene u fiziologiji i ponašanju su moguće. Drugi rizik za okoliš se očituje u mogućem utjecaju zbjegova uzgojne ribe iz kaveza prisutne u morskom okolišu kao rezultat slučajnog bijega iz kaveza ili namjernog poribljavanja. Pobjezi ili poribljavane jedinke iz uzgoja predstavljaju potencijalni rizik genetskoj osnovi izvornih ribljih populacija. Zbog boljeg razumijevanja složenosti  utjecaja akvakulture na prirodne populacije, ovaj projekt će iskoristiti najnovije instrumentalne i genetske pristupe s ciljem podržavanja uzgojnih i upravljačkih aktivnosti, kao i zaštite morskog okoliša. Projekt uključuje: (i) uporabu suvremenog sustava stereoskopske kamere i multivarijatnih analizi indirektnih pokazatelja kondicije s ciljem procjene uloge uzgajališta kao ekoloških zamki divljih ribljih populacija, (ii) korištenje forenzički svojstvenih genetskih alata u procjeni genetske strukture divljih/uzgojnih riba i školjkaša , (iii) uporaba suvremenog genetski-analitičkog pristupa s ciljem određivanja porijekla uzgojnih populacija i utvrđivanja možebitnih genetskih interakcija populacija iz uzgoja s prirodnim/divljim populacijama iste vrste, a na kraju (iv) procjena utjecaja translokacije mlađi kamenica između geografski udaljenih uzgojnih lokacija na genetsku strukturu izvornih populacija kamenice u hrvatskom dijelu Jadrana.Zaključno, predloženi projekt se nadovezuje na zajednički izazov evropske zajednice  koji se očituje u poticanju razvoja održive akvakulture kroz poboljšanje konkurentnosti i ekološki prihvatljive proizvodnje. Kako su potencijalno negativni učinci akvakulture prisutni u svim zemljama EU-a, međunarodna suradnja će se biti prepoznata i implementirana tijekom provedbe projektnih zadataka. Projektni ishodi će biti dostupni svim zainteresiranim strankama odnosno istraživačima, industriji, zakonodavnim tijelima i svim potencijalnim korisnicima.]]></summary_hr><summary_en><![CDATA[Expansion of marine farming sites raised the concern that aquaculture may pose a threat to biodiversity due to detrimental impacts on wild populations and ecosystem. Ecological interactions of farm installations are reflected through  acting as new ecological niches for the local fish where also altered wild fish physiology and behaviour may occur. Another environmental risk is the potential impact of releasing farmed fish into the wild, through accidental escape or deliberate restocking. Escapes or releases of the domesticated aquaculture fish pose a potential risk of adverse effects on native fish gene pools. To better understand the complexity of aquaculture impacts on the native populations, this project will take advantage of cutting edge instrumental and genetic approaches to support aquaculture activity and management, as well as the protection of marine environment. This includes: (i) using novel stereoscopic camera system and multivariable analysis of proxy measure of fitness to asses do farms function as ecological traps for wild fish, (ii) using forensically validated genetic tools to assess genetic structure of wild/farmed fish and shellfish, (iii) using cutting edge genetic analytical approach to trace the origin of farmed fish and to monitor genetic interactions between fish from aquaculture and their wild conspecifics, and finally (iv) validation of the impact of oyster spat translocation between geographically distinct farming locations on genetic structure of native oysters populations in the Croatian part of the Adriatic Sea. Thus, this project addresses the common European challenge to develop sustainable aquaculture through improved competitiveness and environmentally-friendly production. As the potential adverse effects of aquaculture affect all EU countries, international collaboration will be implemented. The outcome of the project will be available to the researchers, the industry, policy makers and the general public.]]></summary_en></project><project>
<id>7547</id><title_hr><![CDATA[Uloga unutarstaničnog života Francisella tularensis u patogenezi eksperimentalne tularemije]]></title_hr><title_en><![CDATA[]]></title_en><user_id>114</user_id><user_firstLast_name>Marina Šantić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-01</proposal_call><code>DOK-2018-01-3785</code><acronim><![CDATA[FRANCYCLE]]></acronim><duration>02.07.2018 - 31.12.2022</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Medicine]]></institution_en><team_members_id>25206</team_members_id><team_members_names><![CDATA[ Doktorand: Ina Kelava ]]></team_members_names><keywords_hr><![CDATA[Francisella, FPO, sazrijavanje fagosoma/vakuole, autofagija, in vitro, in vivo]]></keywords_hr><keywords_en><![CDATA[Francisella, FPI, phagosome/vacuole maturation, autophagy, in vitro, in vivo]]></keywords_en><summary_hr><![CDATA[Francisella tularensis je gram-negativna, visoko infektivna, fakultativno unutarstanična bakterija koja uzrokuje tularemiju. Unutarstanični život F. tularensis je jedinstven u odnosu na druge unutarstanične bakterije. Fagosom koji sadrži francizelu (FCP - Francisella containing phagosome) zaustavljen je u fazi kasnog nezakiseljenog endosoma, nakon čega slijedi postupni bakterijski izlazak u citosol. Očito je da Francisella kruži kroz različite unutarstanične odjeljke; FCP i vakuolu koja sadrži francizelu (FCV – Franicisella containing vacuole). Zbog važnosti ovih staničnih odjeljaka u uspostavi i održavanju infekcije, po prvi put ćemo izolirati FCP i FCV iz makrofaga. Ovo je potpuno novi pristup u razumijevanju njihove uloge u unutarstaničnom životu francizela. Nadalje, pretpostavljamo da se značajni dio interakcije sa citosolom domaćina ostvaruje putem autofagije. Moguće je da, u kasnijoj fazi infekcije, Francisella oblikuje oštećenu FCV u autofagnu vakuolu. Brojna su istraživanja usredotočena na dio bakterijskog genoma poznatijem kao Francizela patogeni otok (FPO). Mnoge FPO mutante pokazuju jednoobrazan fenotip karakteriziran nemogućnošću bijega iz fagosoma, izostankom unutarstanične replikacije te gubitkom virulencije in vivo. Želimo dokazati da su FPO proteini (PdpC, IglC, IglI, PdpE i IglG) koji su efektori tipa VI sekrecijskog sustava uključeni u regulaciju procesa autofagije. Autofagija se smatra jednim od efektorskih mehanizama urođene imunosti protiv unutarstaničnih bakterija. Podaci o ulozi autofagije u regulaciji citokinske mreže tijekom tularemije su još uvijek rijetki i proturječni. Stoga bi naša daljnja istraživanja, posebno u modelu Atg5 transgeničnih miševa, trebala pridonijeti boljem razumijevanju autofagije kao imunom odgovoru na infekciju francizelom. Očekivani rezultati doprinijet će rasvjetljavanju patogeneze tularemije te pridonijeti razvoju novih terapijskih i preventivnih strategija baziranih na autofagiji.]]></summary_hr><summary_en><![CDATA[Francisella tularensis is a highly virulent facultative intracellular pathogen that causes  disease tularemia. The intracellular lifestyle of F. tularensis is unique compared to other intracellular pathogens. The Francisella-containing phagosome (FCP) is arrested at a non-acidified late endosome-like stage, which is followed by gradual bacterial escape into the cytosol. It is obvious that Francisella cycles through different intracellular compartments; FCP and the Francisella-containing vacuole (FCV). Because of the importance of these subcellular compartments during infection, we will establish a novel method of isolating the FCP/FCV from macrophages. This is an innovative approach in understanding their role in Francisella intracellular life cycle. Secondly, we proposed that the great part of communication with the host cytosol environment is accomplished by autophagy. We assume that Francisella reseal damaged FCV into the autophagic vacuole later during the infection. Many studies have been focused on a genomic region called the Francisella pathogenicity island (FPI). Some of the FPI mutants show a uniform phenotype characterized by lack of phagosomal escape, no intracellular replication, and a loss of virulence in vivo. We expect to find that FPI proteins, PdpC, IglC, IglI, PdpE, and IglG that are effectors of the type VI secretion system are also involved in manipulation of autophagy machinery. Autophagy is regarded as one of the innate immunity effectors against intracellular bacteria. However, the data on the role of autophagy in the regulation of cytokine networks by Francisella are still unknown. We propose a new concept using transgenic Atg5 mouse that should contribute to a better understanding of autophagy as host immune response to Francisella infections. The project will contribute to understanding the pathogenesis of tularemia, providing opportunities for the development of novel autophagy-based therapeutic and preventive strategies.]]></summary_en></project><project>
<id>7548</id><title_hr><![CDATA[Napredni deterministički i hibridni algoritmi na nizovima, sljedovima i stablima s primjenama u tehničkim znanostima i znanostima o životu]]></title_hr><title_en><![CDATA[Advanced deterministic and hybrid algorithms on strings, sequences and trees with applications in technical and life sciences]]></title_en><user_id>4140</user_id><user_firstLast_name>Strahil Ristov</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2018-01</proposal_call><code>IP-2018-01-7317</code><acronim><![CDATA[ALGSEQ18]]></acronim><duration>01.10.2018 - 30.09.2022</duration><status>Završio</status><financ_value>112.150,77 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Računarstvo, Temeljne tehničke znanosti, Interdisciplinarne tehničke znanosti, </scie_field_hr><scie_field_en>Computer sciences, Basic engineering sciences, Interdisciplinary technological sciences, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>6650, 864917, </team_members_id><team_members_names><![CDATA[Ino Čurik, Dalibor Hršak, ]]></team_members_names><keywords_hr><![CDATA[algoritmi, računarska teorija, kompaktne strukture podataka, promjenljive strukture podataka, bioinformatika, populacijska genetika]]></keywords_hr><keywords_en><![CDATA[algorithms, theoretical computer science, compact data structures, dynamic data structures, bioinformatics, population genetics]]></keywords_en><summary_hr><![CDATA[Deterministički kombinatorni algoritmi na nizovima i sljedovima temeljni su dio u rješenjima mnogih računarskih problema u tehničkim znanostima i znanostima o životu. U tehničkim znanostima radi se o sažimanju, pohrani, te pretrazi i dohvatu podataka. U znanostima o životu ti se postupci specifično primjenjuju na velike količine podataka o biološkim sekvencama. U novije vrijeme, veliko povećanje raspoloživih podataka (big data) stvorilo je potrebu za novim rješenjima i naprednijim algoritmima. U nekim primjenama koriste se hibridni postupci koji uključuju i probabilističke metode, kao što su to skriveni Markovljevi lanci, no u većini rješenja problema na nizovima i sljedovima postoji kombinatorna podloga. U ovom projektu, originalni postupci temeljeni na kombinatornom pristupu, koji je prema potrebi nadopunjen probabilističkim, koristit će se, u području tehničkih znanosti, za konstrukciju kompaktnih struktura podataka i rješavanje dinamičkih problema na nizovima. U  području znanosti o životu istraživat će se mogućnosti rješavanja algoritamskih zadaća u bioinformatici koje proizlaze iz različitih oblika problema  mapiranja kraćih dijelova sekvenci na dulje. Također, u području populacijske genetike istraživat će se mogućnost pronalaženja učinkovitije definicije regija homozigotnosti kod diploidnih organizama, te uključivanja detaljnih podataka o sekvencama u pedigre stabla sa svrhom optimiziranja populacijskih analiza i poboljšanja uzgojnog procesa u komercijalnim vrstama.Uz to, algoritmi na stablima će biti korišteni za optimizaciju postupka izbora jedinki od kojih treba uzeti uzorke DNA za optimalnu analizu populacije.]]></summary_hr><summary_en><![CDATA[Deterministic combinatorial algorithms on strings and sequences are central part of many computational solutions of problems in technical and life sciences. The relevant methods in technical sciences mainly include those for the compression, storage, and search and retrieval of data. In life sciences, these methods are specifically applied on huge amounts of biological sequence data. Recently, large increase in quantity of the available data (big data) has induced the need for novel and advanced algorithmic solutions. Some of the problems require the hybrid solutions that include probabilistic methods, such as hidden Markov models. However, in most of the solutions of the problems on strings and sequences there exists a central combinatorial part. In this project, original methods based on the combinatorial approach, and in some instances complemented with the probabilistic approach, will be used, in the field of computer science, for the construction of compact data structures and for solving dynamical problems on strings. In life sciences field, these types of methods will be used, in bioinformatics, to investigate possible solutions of various algorithmic problems arising from the task of mapping shorter sequence parts to the longer sequence. In the population genetics field, the possibility of finding a more productive definition of regions (runs) of homozigosity in diploid organisms will be investigated, as well as the inclusion of the detailed sequence data into pedigree trees, with the goal of optimizing the population analysis and improving the breeding selection for commercial species. Additionally, algorithms on trees will be used for the optimization of the process of the selection of individuals from which the sample should be taken for the optimal population analysis.]]></summary_en></project><project>
<id>7549</id><title_hr><![CDATA[Profesionalizam u zdravstvu]]></title_hr><title_en><![CDATA[]]></title_en><user_id>776</user_id><user_firstLast_name>Ana Marušić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-01</proposal_call><code>DOK-2018-01-3134</code><acronim><![CDATA[ProHealth]]></acronim><duration>01.09.2018 - 31.08.2021</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Javno zdravstvo i zdravstvena zaštita, </scie_field_hr><scie_field_en>Public health and health services, </scie_field_en><institution_hr><![CDATA[Sveučilište u Splitu, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Split School of Medicine]]></institution_en><team_members_id>25225</team_members_id><team_members_names><![CDATA[ Doktorand: Marin Viđak ]]></team_members_names><keywords_hr><![CDATA[profesionalizam, zdravstvena skrb, profesionalci, integritet, izvrsnost, odgovornost, transparencija]]></keywords_hr><keywords_en><![CDATA[professionalism, health care, students, professionals, integrity, excellence, accountability, transparence]]></keywords_en><summary_hr><![CDATA[Predloženi projekt ima za cilj istraživanje izvrsnosti, odgovornosti i integriteta/transparencije kao atributa profesionalizma koji su relevantni za zdravstvenu skrb utemeljenu na dokazima, gdje je profesionalizam široko definiran kao predanost izvršavanju profesionalne zadaća, pridržavanju etičkih principa i osjetljivosti za pacijentovu dobrobit. Prva istraživačka tema projekta usmjerena je na profesionalizam u studenata. Istražit ćemo determinante profesionalnog razvoja studenata, kao i okružje za razvoj profesionalne izvrsnosti i integriteta. Temeljem nalaza iz tog dijela istraživanja, razvit ćemo i testirati intervencije za poticanje razvoja profesionalizma tijekom studija. Druga istraživačka tema usmjerena je na profesionalizam u praksi zdravstvene skrbi. Prvo ćemo usporediti okvire za profesionalnu izvrsnost i integritet, uključujući i dokaze dostupne zdravstvenim profesionalcima i njihovu translaciju u praksi. Temeljem nalazi iz tog dijela istraživanja, razvit ćemo i testirati intervencije za poboljšanje profesionalne prakse. Pristup svakom specifičnom cilj istraživanja uključit će 1) mapiranje trenutnog znanja i identifikacija područja s manjkavim znanjem, 2) uporabu adekvatnih istraživačkih ustroja i metodologija, 3) sinteza rezultata istraživanja u eksplanatorne teorije i modele i 4) razvoj i diseminacija aplikacija važnih za javnu politiku i pristup zdravstvenoj skrbi. Rezultati predloženih istraživanja pridonijet će boljem razumijevanju kako se profesionalizam razvija tijekom obrazovanja i prakse u zdravstvenoj skrbi. Razvojem i testiranjem novih intervencija za poticanje razvoja profesionalizma, projekt će donijeti dokaze za promicanje kurikularnog i cjeloživotnog učenja i za promjenu politike zdravstvene skrbi, kao i donijeti važne ekonomske i javnozdravstvene koristi.]]></summary_hr><summary_en><![CDATA[The proposed project aims to study excellence, accountability and integrity/transparency as attributes of professionalism which are most relevant for evidence-based healthcare, where professionalism is broadly defined as commitment to carrying out professional responsibilities, adherence to ethical principles and sensitivity to patient populations. The first research theme addresses professionalism in healthcare students. We will investigate the determinants of professional development in students, as well as the environment for the development of professional excellence and integrity. Based on the findings from this research, we will develop and test interventions for teaching professionalism in health curricula. The second research theme addresses professionalism in healthcare practice. We will first describe the framework for professional excellence and integrity, including the evidence available to healthcare practitioners and its translation to practice. Based on research results, we will develop and test interventions for professional practice. Each specific objective will include: 1) mapping of current research results and identification of knowledge gaps, 2) using appropriate research design and methodology, 3) synthesising research results into explanatory theories and models, and 4) developing and disseminating applications relevant for policy and public use. Results from the proposed research will contribute to better understanding of how professionalism develops during healthcare education and practice. By developing and testing new interventions for professionalism, the project will provide evidence for the advancement of curricular and life-long learning and policy changes in healthcare, as well as bring important economic and public health benefits.]]></summary_en></project><project>
<id>7550</id><title_hr><![CDATA[Detaljan uvid u mehanizme polaronske i ionske vodljivosti u oksidnoj staklo-(keramici)]]></title_hr><title_en><![CDATA[Expanding insights into the mechanisms of POLARonic and IONic conduction in oxide GLASS-(ceramics)]]></title_en><user_id>3297</user_id><user_firstLast_name>Ana Šantić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2018-01</proposal_call><code>IP-2018-01-5425</code><acronim><![CDATA[POLAR-ION-GLASS]]></acronim><duration>19.10.2018 - 18.03.2023</duration><status>Završio</status><financ_value>132.722,81 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, </scie_field_hr><scie_field_en>Chemistry, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>4869, 3421, 3302, 23899, 13670, 13669, 23663, 13648, 26576, 865074, </team_members_id><team_members_names><![CDATA[Andrea Moguš-Milanković, Luka Pavić, Kristina  Sklepić, Radha Dilip Banhatti, Ladislav Koudelka, Petr Mosner, Petr Kalenda, Grégory Tricot, Sanja Renka, Sara Marijan, ]]></team_members_names><keywords_hr><![CDATA[staklo, staklo-keramika, ionska vodljivost, polaronska vodljivost, struktura]]></keywords_hr><keywords_en><![CDATA[glasses, glass-ceramics, ionic conductivity, polaronic conductivity, structure]]></keywords_en><summary_hr><![CDATA[Električki vodljiva oksidna stakla važni su elektrolitni/elektrodni materijali koji se sve više primijenjuju u modernim elektrokemijskim uređajima. U ovim staklima tip električne vodljivosti (polaronski, ionski ili miješani ionsko-polaronski) ovisi o sastavu stakla, dok utjecaj međudjelovanja nositelja naboja s lokalnim strukturnim okruženjem definira mehanizam transporta. Zbog strukturne neuređenosti i velike raznolikosti strukturnih jedinica razumijevanje električnog transporta na mikroskopskoj skali u staklu predstavlja veliki izazov. Glavni je cilj predloženog projekta razjasniti mehanizme polaronske i ionske vodljivosti u volframsko- i molibdensko-fosfatnim staklima i staklo-keramici s posebnim naglaskom na povezanost sa strukturom. Predloženo istraživanje sastoji se od tri međusobno povezana koraka: 1) određivanje faktora koji određuju polaronsku vodljivost u binarnim volframsko- i molibdensko-fosfatnim staklima, 2) istraživanje miješanog ionsko-polaronskog transporta u volframsko- i molibdensko-fosfatnim staklima koja sadrže alkalijske okside i 3) ispitivanje utjecaja kristalizacije na električni transport u odabranim modelnim staklima iz koraka 1) i 2) s ciljem priprave vodljive staklo-keramike s prilagodljivim doprinosom ionske i polaronske vodljivosti. Odabrani sustavi posebno su atraktivni za primjenu kao katode u krutim baterijama jer fosforov oksid tvori stakla s alkalijskim i prijelaznim metalnim oksidima u širokom koncentracijskom području što omogućava visoku polaronsku i ionsku vodljivost. Detaljna strukturna i električna karakterizacija neophodna za rasvjetljavanje i povezivanje procesa polaronskog i ionskog transporta u ovim materijalima provest će se nizom naprednih komplementarnih metoda (Ramanska, MAS NMR i EPR spektroskopija, neutronska i rendgenska difrakcija, impedancijska spektroskopija, DC mjerenja), a značajan uvid u elementarne procese gibanja polarona i iona dat će numeričko modeliranje električne provodnosti MIGRATION konceptom.]]></summary_hr><summary_en><![CDATA[Electrically conducting oxide glasses are an important class of electrolyte/electrode materials whose application in modern electrochemical devices are growing rapidly. The type of conduction (polaronic, ionic or mixed polaronic-ionic) in these glasses depends on the composition, while the transport mechanism itself is strongly influenced by the interaction of charge carriers with the local structural environment and understanding it from a microscopic point of view poses a major challenge. The overall aim of the proposed project is to clarify the mechanisms of polaronic and ionic conduction in tungsten phosphate and molybdenum phosphate glasses and glass-ceramics with a special emphasis on their correlation to the structure. The proposed research contains three interconnected steps: 1) identification of factors that govern polaronic conduction in binary tungsten/molybdenum phosphate glasses, 2) investigation of the mixed conduction in tungsten/molybdenum phosphate glasses containing alkali oxides and 3) study of the influence of crystallization on electrical transport in selected glasses from steps 1) and 2) in order to obtain highly conductive glass-ceramics with tuneable contributions of polaronic and ionic conduction. The chosen phosphate glasses are especially attractive for application as cathodes in solid-state batteries because they can accommodate a considerable amounts of transition metal and alkali oxides, and hence exhibit high polaronic and ionic conductivity. Detailed structural and electrical characterizations which are needed for resolving and relating processes of polaronic and ionic transport in these materials will be achieved using various advanced methods (Raman, MAS NMR and EPR spectroscopy, neutron and X-ray diffraction, impedance spectroscopy, DC measurements), while the numerical modelling of electrical conductivity using MIGRATION concept will give additional valuable insights into the elementary processes of polaronic and ionic motions.]]></summary_en></project><project>
<id>7551</id><title_hr><![CDATA[Sinkroni reluktantni generatori za mikro hidroelektrane]]></title_hr><title_en><![CDATA[Synchronous reluctance generators for micro hydropower plants]]></title_en><user_id>1528</user_id><user_firstLast_name>Stjepan Stipetić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2018-01</proposal_call><code>IP-2018-01-5822</code><acronim><![CDATA[HYDREL]]></acronim><duration>01.11.2018 - 31.10.2022</duration><status>Završio</status><financ_value>128.910,88 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Temeljne tehničke znanosti, Elektrotehnika, </scie_field_hr><scie_field_en>Basic engineering sciences, Electrical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id>23934, 19026, 6380, 3873, 2534, 3953, 22617, 2703, 22554, 6695, 23940, 28672, 25402, 25401, 25403, 5949, </team_members_id><team_members_names><![CDATA[Ivana Pavlić, Igor Sirotić, Igor Erceg, Damir Žarko, Marinko Kovačić, Zlatko Hanić, Filip Jukić, Mario Vražić, Luka Pravica, Martina Kutija, Nikola Vuger, Marijan Martinović, Niksa Ćavar, Mario Klanac, Dora Penić, Damir Sumina, ]]></team_members_names><keywords_hr><![CDATA[sinkroni generatori, reluktantni strojevi, mikro hidroelektrane, optimizacija, energetski pretvarači]]></keywords_hr><keywords_en><![CDATA[synchronous generators, reluctance machines, micro hydropower plants, optimisation, power electronic converter]]></keywords_en><summary_hr><![CDATA[Učinkovita potrošnja energije i povećana upotreba energije iz obnovljivih izvora su promovirane strateškim planovima Europske unije i Hrvatske. Mikro, mini i male hidroelektrane imaju značajan neiskorišteni potencijal i prednost pred energijom vjetra i sunčevom energijom u stabilnijoj i predvidivoj proizvodnji. Vodna turbina i električni generator su ključni elementi takvih sustava koji trebaju imati nisku cijenu, visoku učinkovitost i pouzdanost. Novi sustavi za pretvorbu energije su temeljeni na turbini promjenjive brzine vrtnje i na generatoru spojenom na energetski pretvarač čime se ostvaruje fleksibilan sustav za upravljanje radnom i jalovom snagom. Topologije generatora, koje nude visoku učinkovitost, temeljene su na stalnim magnetima s elementima rijetkih zemalja koji imaju visoku i nestabilnu cijenu na tržištu i čija proizvodnja ima iznimno negativan učinak na okoliš. Alternativa strojevima sa stalnim magnetima su sinkroni reluktantni strojevi, jednostavnog robusnog dizajna bez magneta, visoke učinkovitosti i niske cijene.Projekt HYDREL istražuje mogućnosti korištenja reluktantnih strojeva kao generatora u mikro hidroelektranama. Istraživanja i inovacije na projektu HYDREL su usredotočeni na sljedeće ciljeve: (i) istraživanje koncepta proizvodnje energije u mikro hidroelektranama inovativnim simulacijskim sustavom, (ii) istraživanje inovativnih i optimalnih oblika rotorskih barijera uz projektiranje i izradu prototipa reluktantnih generatora visoke učinkovitosti, (iii) projektiranje i izradu prototipa energetskog pretvarača s optimiranim filterskim komponentama, (iv) istraživanje inovativnog upravljačkog algoritma za energetski učinkovito upravljanje uz identifikaciju i adaptaciju parametara generatora. Razvijeni koncepti će biti potvrđeni simulacijskim modelima i eksperimentalno na laboratorijskom postavu dva mehanički spojena prototipna stroja, koji predstavljaju turbinu i generator, a spojeni su na mrežu preko prototipa energetskog pretvarača.]]></summary_hr><summary_en><![CDATA[Efficient energy consumption and the increased use of energy from renewable sources are promoted by strategic plans of the European Union and Croatia. Micro, mini and small hydropower plants have a significant unused potential and an advantage over wind and solar in more stable and predictable energy production. Water turbine and electrical generator are the key elements of such systems which need to have low cost, high efficiency, and reliability. Novel systems for energy conversion are based on the variable speed turbine and on the synchronous generator coupled with the power converter thus forming a flexible system capable of active and reactive power control. The most efficient generator topologies are based on rare-earth permanent magnets which have high and unstable price and whose manufacturing has an extremely negative environmental impact. An alternative to permanent magnet machines are the synchronous reluctance machines, which have simple robust design without magnets, high efficiency, and low cost.HYDREL project explores the capability of exploiting synchronous reluctance machine as a main generating unit in a micro hydropower plant. As a step forward in research and innovation, the focus of HYDREL is set on the following objectives: (i) research on power generation concept of micro hydropower plant through innovative simulation environment, (ii) research on innovative and optimal rotor flux barrier shapes along with design and prototyping of two high-efficiency synchronous reluctance generators, (iii) design and prototyping of power electronic converter with optimized filter components, (iv) research on innovative energy-efficient control algorithm with identification and adaptation of generator parameters. The developed system will be experimentally verified on the test rig consisting of two coupled prototyped machines representing turbine-generator system connected to the electrical grid through a prototyped power electronic converter.]]></summary_en></project><project>
<id>7552</id><title_hr><![CDATA[Unapređenje usluga šumskih ekosustava Hrvatske kroz vrednovanje bioraznolikosti gljiva temeljenoj na DNA barkodiranju]]></title_hr><title_en><![CDATA[Enhancement of Croatian forest ecosystem services through assessment of fungal diversity based on DNA barcoding ]]></title_en><user_id>19224</user_id><user_firstLast_name>Armin Mešić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2018-01</proposal_call><code>IP-2018-01-1736</code><acronim><![CDATA[ForFungiDNA]]></acronim><duration>01.10.2018 - 15.02.2023</duration><status>Završio</status><financ_value>126.153,03 eur</financ_value><scie_area_hr>Biotehničke znanosti, Prirodne znanosti, </scie_area_hr><scie_area_en>Biotechnical sciences, Natural sciences, </scie_area_en><scie_field_hr>Šumarstvo, Biologija, Interdisciplinarne biotehničke znanosti, </scie_field_hr><scie_field_en>Forestry, Biology, Interdisciplinary biotechnical sciences, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>5710, 13114, 12839, 13120, 13180, 12438, 5744, 23931, 23880, 23894, 5235, 27440, 26553, 865066, </team_members_id><team_members_names><![CDATA[Zdenko Tkalčec, Ivana Kušan, Margita Jadan, Neven Matočec, Tine Grebenc, Željko Zgrablić, Sanja Novak Agbaba, Dino Buršić, Ondřej Koukol, Luis Jesús Quijada Fumero, Nevenka Ćelepirović, Zuzana  Sochorová , Ana Pošta, Lucia Pole, ]]></team_members_names><keywords_hr><![CDATA[šumarstvo, usluge šumskih ekosustava, gljive, bioraznolikost, DNA barkodiranje, integrativna taksonomija, biogeografija, fitopatologija]]></keywords_hr><keywords_en><![CDATA[forestry, forest ecosystem services, fungi, biodiversity, DNA barcoding, integrative taxonomy, biogeography, phytopathology]]></keywords_en><summary_hr><![CDATA[Usluge ekosustava su ekološke značajke, funkcije ili procesi ekosustava koji imaju utjecaj na ljudsko blagostanje. Očuvanje cjelokupne biološke raznolikosti u šumama ima izrazito pozitivan utjecaj na unapređivanje usluga šumskih ekosustava. U ukupnoj kopnenoj površini Republike Hrvatske šume zauzimaju oko 37%. Zbog položaja na razmeđi kontinentalne, sredozemne, panonske i alpske biogeografske regije, Hrvatska se u europskim okvirima ističe vrlo velikom bioraznolikošću. Šume su najsloženiji kopneni ekosustavi i najznačajniji tip staništa za gljive u kojem živi najveći broj gljivljih vrsta. Gljive u šumskim staništima imaju ključne ekološke uloge i nužne su za zdravlje i opstanak šuma. Ljudski utjecaj koji se ogleda u često prekomjernom iskorištavanju prirodnih resursa i položaj u jednom od svjetskih žarišta klimatskih promjena čine biološku raznolikost u hrvatskim šumama vrlo ugroženom. Gljive su u Hrvatskoj daleko najslabije istražena skupina organizama, pri čemu je do danas poznato tek oko 23% od ukupno procijenjenog broja vrsta. Glavni cilj projekta je istražiti bioraznolikost gljiva u šumama Hrvatske uz pomoć metoda DNA barkodiranja, te analizirati njen utjecaj na usluge šumskih ekosustava. Važan rezultat projekta biti će nadopunjavanje bioinformatičkih međunarodnih baza podataka DNA sekvencama gljivljih vrsta koje do danas u tim bazama nisu zastupljene. Sve vrste za koje su u ovom projektu dobiveni DNA barkodovi kategorizirat će se u trofičke skupine (patogene, mikorizne i saprotrofne vrste) i procijenit će se status ugroženosti tih vrsta u Hrvatskoj. Rezultati projekta imat će veliki potencijal primjene u šumarstvu, prehrambenoj industriji, farmaciji te zaštiti prirode. Podaci o DNA barkodovima vrsta gljiva posebno će biti značajni u šumarstvu za relativno brzu i preciznu identifikaciju, kontrolu i suzbijanje patogena drveća, ali i za identifikaciju mikoriznih i saprotrofnih vrsta.]]></summary_hr><summary_en><![CDATA[Ecosystem services are the ecological characteristics, functions, or ecosystem processes that contribute to human wellbeing. Conservation of the overall biodiversity in the forests has strong positive effect on the enhancement of forest ecosystem services. About 37% of the total land area of the Republic of Croatia is covered by forests. Croatia is distinguished by the great biodiversity due to its position on the dividing line between Continental, Mediterranean, Pannonian and Alpine biogeographical regions. Forests are the most complex terrestrial ecosystems and the most important habitat for fungi. Fungi play key ecological roles in the forests and are necessary for the forest health and existence. Human over-exploitation of natural resources and the geographical position of Croatia in the climate change hot-spot area, make biodiversity of its forests highly endangered. Fungi are the far least studied group of organisms in Croatia with only 23% of species recorded so far out of the total estimated number. The main project aim is to study fungal biodiversity of Croatian forests through the DNA barcoding methods and to analyze its impact on forest ecosystem services. The project will result in the addition of fungal DNA sequences to international bioinformatic databases for a number of species that are not represented in these bases to date. All DNA barcoded species in this project will be categorised in trophic groups (pathogens, saprotrophs, and mycorrhizal species) and the intensity of their impact on the forest ecosystem services will be assessed. The project results will have great potential for different applications in forestry, food industry, pharmacy and nature conservation. Application of DNA fungal barcodes will be especially important in forestry for relatively fast and accurate identification, control, and suppression of plant pathogens, as well as for identification of mycorrhizal and saprotrophic species.]]></summary_en></project><project>
<id>7558</id><title_hr><![CDATA[Dinamika defekta u nanomaterijalima: istraživanje putem eksperimenata s ionskim tragovima]]></title_hr><title_en><![CDATA[Defects dynamics in NanoMaterials: research based on Ion Track Experiments]]></title_en><user_id>3498</user_id><user_firstLast_name>Marko Karlušić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2018-01</proposal_call><code>IP-2018-01-2786</code><acronim><![CDATA[DyNaMITE++]]></acronim><duration>01.11.2018 - 31.12.2022</duration><status>Završio</status><financ_value>132.457,36 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, </scie_field_hr><scie_field_en>Physics, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>21267, 4589, 4976, 2639, 5438, 25833, 25293, 865268, </team_members_id><team_members_names><![CDATA[Kristina Tomić, Stjepko Fazinić, Iva Božičević Mihalić, Pavo Dubček, Branko Šantić, Juraj Hanžek, Damjan Iveković, Sunil Kumar, ]]></team_members_names><keywords_hr><![CDATA[brzi teški ion, ionski trag, defekt, RBS/c, Ramanova spektroskopija, AFM, grafen]]></keywords_hr><keywords_en><![CDATA[swift heavy ion, ion track, defect, RBS/c, Raman spectroscopy, AFM, graphene]]></keywords_en><summary_hr><![CDATA[Napredni materijali i napredne tehnike procesiranja materijala osnova su suvremene tehnologije. Znanstveni napredak započet nedavnim otkrićem grafena koji u jednom materijalu sažima više izvanrednih svojstava, obećaje naslućene mogućnosti koje bi mogle uzrokovati velike promjene u sadašnjim industrijskim procesima i rezultirati radikalno novim proizvodima. Zato je kontrola svojstava ovih novih i uzbudljivih nanomaterijala od najveće važnosti za bilo koju industrijsku primjenu.Ionska implantacija je dobar primjer u kojem električna svojstva poluvodiča mogu biti dopiranjem podešavana u ogromnom rasponu. Visokoenergetska ozračavanja ionima se također mogu koristiti za kontroliranje svojstava materijala, ali putem inženjeringa defekata (tj. pomoću ionskih tragova). Ova vrsta zračenja je našla mnogobrojne primjene, npr. u proizvodnji membrana, hadronterapiji i istraživanjima skladištenja nuklearnog otpada.Cilj projekta je detaljno istraživanje defekata i njihove dinamike u naprednim materijalima tijekom zračenja visokoenergetskim ionima, a u svrhu da bi se odredili pogodni uvjeti za inženjering defekata. U fokusu su istraživanja defekata u grafenu i drugim izabranim 2D materijalima pomoću AFM/STM i Ramanove spektroskopije. Komplementarno ovom istraživanju bit će provedene studije o inženjeringu defekata putem visokoenergetskih ionskih snopova u drugim tehnološki važnim materijalima pomoću RBS/c-PIXE/c i AFM. Kako bi zadobili potpunu kontrolu nad defektima unesenim putem ionskih snopova, važno je razumijeti osnovne procese koji utječu na stvaranje defekata i njihovu dinamiku. Stoga, očekujemo da rezultati projekta pruže uvid u procese koji vladaju dinamikom defekata u naprednim materijalima tijekom zračenja ionima. Očekujemo da će rezultati projekta imati utjecaj na primjene poput senzora i katalizatora, putem novih funkcionalnih svojstava materijala dobivenih inženjeringom defekata. ]]></summary_hr><summary_en><![CDATA[Advanced materials and advanced materials processing techniques are basis of the present-day technology. Scientific advances initiated by recent discovery of graphene that captures many extraordinary properties in a single material promises unpreceded benefits that should justify disruption of current industrial processes, thus giving birth to radically new products. Clearly, to control properties of these new and exciting nanomaterials is of paramount importance for any kind of industrial application. Ion implantation is good example where electrical properties of semiconductors can be tuned in extraordinary wide range by ion doping. High energy ion irradiations can also be used to control materials properties, but in this instance control is achieved via defect engineering (i.e. ion tracks). This kind of irradiation has found many uses in diverse applications like track-etch-membrane production, hadron therapy, and nuclear waste storage studies.The aim of the project is to study in detail defects and their dynamics in advanced materials during high energy ion irradiation, in order to establish suitable conditions for defects engineering. In the research focus is defects analysis in graphene and other selected 2D materials using AFM/STM and Raman spectroscopy. Complementary to this research, studies of defects engineering by high energy ion beams in other technologically relevant materials using RBS/c-PIXE/c and AFM will be undertaken. To gain full control over defect engineering using ion beams, it is important to understand basic mechanisms governing defect production and their dynamics. Therefore, expected results of the project will provide insight into processes governing defect dynamics in advanced materials during ion irradiation. We expected project results to have impact on applications, like sensing and catalysis, due to new materials functionalities gained by defects engineering.]]></summary_en></project><project>
<id>7559</id><title_hr><![CDATA[Laboratorij za geoprostorne analize]]></title_hr><title_en><![CDATA[]]></title_en><user_id>12395</user_id><user_firstLast_name>Ante Šiljeg</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-01</proposal_call><code>DOK-2018-01-5748</code><acronim><![CDATA[GAL / GAL]]></acronim><duration>18.12.2019 - 17.07.2022</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Interdisciplinarno područje znanosti</scie_area_hr><scie_area_en>Interdisciplinary scientific area</scie_area_en><scie_field_hr>Geografija, </scie_field_hr><scie_field_en>Geography, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zadru]]></institution_hr><institution_en><![CDATA[University of Zadar]]></institution_en><team_members_id>22524</team_members_id><team_members_names><![CDATA[ Doktorand: Neda Kulenović ]]></team_members_names><keywords_hr><![CDATA[daljinska istraživanja, GIS, LiDAR, morfometrijske analize, UAV, višekriterijske analize]]></keywords_hr><keywords_en><![CDATA[GIS, LiDAR, morphometric analysis, multi-criteria decision analysis, remote sensing, UAV]]></keywords_en><summary_hr><![CDATA[Osnovni  cilj projekta  je uspostava  Laboratorija  za geoprostorne analize  (GAL)  pri  Odjelu  za  geografiju  Sveučilišta  u  Zadru  te  okupljanje  interdisciplinarnog  tima  znanstvenika  iz  različitih  znanstvenih  polja (geografija,  arheologija, geodezija, agronomija). Osnovna  svrha GAL-a  je  provođenje  znanstvenih  istraživanja,  edukacija  mladih  istraživača, primjena novih znanja i tehnologija te razvoj  inovativnih metoda istraživanja. Prva faza uspostave usmjerena je na opremanje laboratorija s najsuvremenijim  uređajima  uz istovremeno usavršavanje istraživačkog  tima. Primjenom GIS-a u kombinaciji sa korištenjem tehnologije daljinskih istraživanja (bespilotna letjelica, 3D-skener, LiDAR, infracrvena kamera, termalna kamera itd.) omogućava se proučavanje određenog procesa  ili pojave u krupnom mjerilu, pri čemu su sve karakteristike promatranog objekta mjerljivo, odnosno kvantitativno opisane. Stoga je drugi cilj ovog projekta usmjeren na primjenu geoprostornih analiza u primijenjenim istraživanjima kroz  (a)  razvoj   višekriterijskog   modela  održivog  upravljanja   na  području  sedrotvornih vodotoka (b) razvijanje novog metodološkog pristupa u proučavanju  jaruga i (c)  pronalaženje  praktičnih  rješenja  kroz  primjenu  geoprostornih  analiza  u arheologiji i agronomiji. Ostvarenje navedenih ciljeva i izvedeni rezultati pokazali bi primjenjivost i opravdanost laboratorija u daljnjim znanstvenim istraživanjima. Jedinstveni doprinos ostvarenja ovog projekta očituje se u tome da bi GAL predstavljao prvi laboratorij za geoprostorne analize u RH koji će biti usmjeren na usavršavanje te promociju i edukaciju mladih znanstvenika kroz njihovo uključivanje u rad laboratorija. Znanstveni doprinos ovog istraživanja iskazati će se kroz pisanje dvije doktorske disertacije, čiji je osnovni cilj istraživanja izrada prvog plana održivog upravljanja sedrotvornim vodotocima te razvoj novog metodološkog koncepta za proučavanje jaruga. ]]></summary_hr><summary_en><![CDATA[The main aim of the project is to set up a Geospatial Analysis Laboratory (GAL) at the Department of Geography, University of Zadar, and to gather an interdisciplinary team of scientists from various fields (geography, archaeology, geodesy, agronomy). GAL&#39;s basic aim is to produce scientific research, educate young researchers, apply new knowledge and technology, and develop innovative research methods. The first phase of the application focuses on equipping the laboratory with the most up-to-date devices and accompanying software, while training the research team. The use of GIS in combination with RS technology (unmanned aerial vehicle, 3D scanner, LiDAR, infrared camera, thermal camera, etc.) facilitates the study of certain processes or phenomena at close range, while their characteristics are measurable, i.e. can be described quantitatively. Therefore, the second goal of the project focuses on the application of geospatial analyses in applied research through (a) the development of multicriteria models of sustainable management in the area of tufa-forming watercourses, (b) the development of a new methodical approach to studying gullies, and (c) discovering practical solutions through applying geospatial analyses in archaeology and agronomy. Achieving these goals and the results produced would demonstrate to applicability of and justification for GAL in further scientific research. The unique contribution of this project would be the creation of the first laboratory for geospatial analysis in Croatia, focusing on training, promoting and educating young scientists by engaging them in its work. The scientific contribution of this research will be seen in two doctoral dissertations, whose basic research topics are concerned with the production of the first plan for the sustainable management of tufa-forming watercourses, and the development of a new methodological concept for studying gullies. ]]></summary_en></project><project>
<id>7560</id><title_hr><![CDATA[Transformacija pepela iz drvene biomase u građevne kompozite s dodanom vrijednošću]]></title_hr><title_en><![CDATA[]]></title_en><user_id>3406</user_id><user_firstLast_name>Nina Štirmer</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-01</proposal_call><code>DOK-2018-01-3084</code><acronim><![CDATA[TAREC2]]></acronim><duration>22.10.2018 - 15.01.2024</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Građevinarstvo, </scie_field_hr><scie_field_en>Civil engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Građevinski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Civil Engineering]]></institution_en><team_members_id>25367</team_members_id><team_members_names><![CDATA[ Doktorand: Jelena Šantek Bajto ]]></team_members_names><keywords_hr><![CDATA[drvna biomasa, pepeo drvne biomase, mineralni kompozit, građevni proizvod, trajnost]]></keywords_hr><keywords_en><![CDATA[wood biomass, wood biomass ash, mineral composite, construction product, durability ]]></keywords_en><summary_hr><![CDATA[Energane na krutu i plinovitu biomasu predstavljaju jedan od najznačajnijih obnovljivih izvora energije u Europskoj uniji te se očekuje da će biti jedan od glavnih aktera pri dostizanju europskog plana za primjenu 20 % obnovljive energije u 2020. Uobičajeno se tijekom izgaranja 1 tone drvne biomase proizvede 5 MWh energije, ali i 20 – 50 kg pepela s dna peći kao i letećeg pepela. Predviđa se da će u EU-28 primjena energije iz energana na drvnu biomasu u budućnosti utjecati na proizvodnju približno 600 000 tona pepela. Trenutno se 70 % biopepela drvne biomase (PDB) odlaže, 20 % se nastoji primijeniti kao dodatak tlu u poljoprivredi i 10 % za ostale namjene. Strategijom energetskog razvoja RH određeno je da će se do 2020. godine koristiti 85 MWe iz biomase. U ožujku 2016. u Hrvatskoj je bilo 10 elektrana na biomasu, potpisano je 57 ugovora s Hrvatskim operatorom tržišta energije za gradnju elektrana u 2014. i 2015. godini (ukupno 95,342 MWe) te su zaprimljeni zahtjevi za odobrenje građenja dodatnih elektrana na biomasu snage 51,034 MWe.Cilj projekta TAREC2 je transformirati pepeo drvne biomase (PDB) u građevne kompozite s dodanom vrijednošću, kroz povezivanje tri ključna aktera s njihovim specifičnim interesima, u industrijsku simbiozu sa zajedničkim komplementarnim interesom, koji je u skladu s EU pravnim okvirima. Prvi akter je energetski sektor koji je korisnik drvne biomase kako bi proizveo energiju i kao rezultat toga proizvođač otpada drvne biomase. Drugi je građevinski sektor koji je korisnik sirovine koju proizvodi energetski sektor. Na kraju, znanost o materijalima služi kao poveznica između dva sektora koja osigurava podatke o sirovini i moguće primjene. Projekt uključuje i optimizaciju i modifikaciju cijelog lanca u tehnologiji procesa: dobivanje pepela iz energetskog procesa, karakterizaciju pepela, određivanje udjela sastojaka mješavine za građevinsku industriju i konačno demonstraciju razvijenog proizvoda i primjenu u građevinskoj industriji. ]]></summary_hr><summary_en><![CDATA[Solid and gaseous biomass fuelled power plants are the biggest source of renewable energy in the EU and are expected to make a key contribution to the 20% EU renewable energy target by 2020. Typically burning of 1 tons of forest biomass and wood waste generates 5 MWh of energy as well as 20 – 50 kg/t of bottom ash and fly ash. It is foreseen that the use of energy from wood biomass plants will lead in the future to the production of approximately 600 000 tons of biomass ash in the EU-28. Currently, 70% of wood biomass ash (WBA) is land filled, 20% tends to be used as a soil supplement in agriculture and 10% is used for miscellaneous application. Energy Sector Development Strategy of the Republic of Croatia determined that by 2020 use of energy from biomass should be 85 MW. In March 2016, there were 10 biomass power plants installed (total power 24.585 MWe). Additionally, 57 contracts were signed with Croatian energy market operator for construction of power plants during 2014 and 2015 (in total 95.342 MWe), while HROTE received requests for approval of construction of additional 51.034 MWe of biomass power plants.TAREC2 aims to transform waste wood biomass ash (WBA) into resilient construction composites, through incorporating three key actors, into an industrial symbiosis with joint complementary interest that is in accordance with EU legal framework. First key actor is the energy sector; user of wood biomass to produce energy and consequently producer of waste wood biomass ash. Another one is construction industry; user of raw material provided by the energy sector. Finally, materials science acts as a bridge between the two sectors, providing information on properties of obtained material and potential application. Project involves the optimization and the modification of the whole chain of process technology: ash obtaining and characterization, mixture proportioning and demonstration of the developed products and the applications in construction industry.]]></summary_en></project><project>
<id>7561</id><title_hr><![CDATA[Dinamični hibridni materijali za novu primjenu temeljeni na metalnim nanočesticama i gelovima]]></title_hr><title_en><![CDATA[]]></title_en><user_id>4406</user_id><user_firstLast_name>Zoran Džolić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-01</proposal_call><code>DOK-2018-01-4114</code><acronim><![CDATA[NanoGelMat]]></acronim><duration>17.09.2018 - 18.09.2022</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, </scie_field_hr><scie_field_en>Chemistry, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>25267</team_members_id><team_members_names><![CDATA[ Doktorand: Toni Grgurić ]]></team_members_names><keywords_hr><![CDATA[supramolekulska kemija, gelovi, metalne nanočestice, plazmoni, meki materijali]]></keywords_hr><keywords_en><![CDATA[supramolecular chemistry, gels, metal nanoparticles, plasmons, soft materials]]></keywords_en><summary_hr><![CDATA[Proučavanje fenomena kiralnosti kod anorganskih nanočestica postaje jedna od vodećih tema istraživanja u nanoznanosti. Otkrivena su nova i zanimljiva svojstva kiralnih nanočestica koja pokazuju buduću primjenu tih sustava u temeljnim (metamaterijali) i primijenjenim (medicinska dijagnostika, terapija karcinoma) istraživanjima. Kiralnost nanočestica je važan parametar u utrci minijaturizacije. Cilj je pripraviti kiralne nanočestice s efektom cirkularnog dikroizma induciranog površinskim plazmonom (SP-CD) u vidljivom i infracrvenom dijelu spektra. Napredak u ovom području istraživanja do sada je bio otežan zbog strukturne složenosti takvih sustava te kompliciranih metoda priprave kiralnih nanočestica. Zbog toga je razvoj učinkovitih metoda priprave kiralnih nanočestica jedan od vodećih izazova s kojim se nanoznanost danas suočava. Nedavno smo izložili novi pristup dizajnu i pripravi kiralnih nanočestica. U njemu je kiralna organizacija nanočestica dobivena upotrebom predloška, supramolekularne gelne niti, po kojem je raspored nanočestica dirigiran &#39;&#39;upisanom informacijom&#39;&#39; unutar gelnih niti. Našim pristupom plazmonski cirkularni dikroizam je dobiven samo-udruživanjem zlatnih nanoštapića po predlošku, gelne niti, s upletenom (engl. twisted) morfologijom. Spektri cirkularnog dikroizma su pokazali intenzivne plazmonom-inducirane Cottonove efekte, a dobivene su do sada najviše vrijednosti anizotropnog faktora za metalne nanočestice u otopini. Predloženi projekt ima za za cilj pojasniti porijeklo fenomena kiralnosti kod anorganskih nanočestica i na molekularnoj razini proširiti saznanja o interakcijama između anorganskih nanočestica i molekula gelatora unutar gelne mreže. Nadalje, unutar ovog projekta planirano je istražiti, upotrebom oksalamidnih derivata kao molekula gelatora, mehanizam nastajanja gelnih niti s kiralnom morfologijom, kao i mogućnosti kontrole dobivene morfologije. ]]></summary_hr><summary_en><![CDATA[The observation of chirality on inorganic nanoparticles (NPs) systems is an interesting and highly important phenomenon which has recently attracted considerable attention and has become a hot topic in nanoscience research. Many novel and interesting properties of chiral NPs have been explored and studied, showing that these systems could be of significant importance in both fundamental and application-oriented research. Very recently we have introduced a new strategy for designing and preparing chiral NPs which relies on a gelator fiber-templated approach in which the local organization is driven by the information already inscribed on the gel fibers. Plasmonic circular dichroism was obtained by chiral 3D organisation of gold nanorods, generated by their self-assembly onto a gel fiber template with twisted morphology. Circular dichroism measurements revealed intense plasmon-induced Cotton effect, and the highest anisotropy factor for metal nanoparticles in solution reported so far. The aim of this project is to gain a molecular-level understanding of the interaction of NPs with the gelators within the gel matrix and of the origin of the chirality observed in the inorganic NPs. Furthermore, a comprehensive understanding of the mechanism of the twist formation and control the chiral twists in oxalamide-based gelator assemblies will be sought. The long-term objective of this project is to explore the correlation between the morphology of the chiral gel fibers and the SP-CD responses of NPs. More specifically, the project will focus on (1) the preparation of nanocomposite chiral materials built-up from supramolecular fibers of different morphology serving as templates for surface assembly of NPs; (2) the screening of their optical properties and on identifying the factors responsible for an efficient optical enhancement; (3) the determination of the characteristics and the origins of the chirality in NPs.]]></summary_en></project><project>
<id>7563</id><title_hr><![CDATA[Stohastički procesi sa skokovima i nelokalni operatori]]></title_hr><title_en><![CDATA[Discontinuous stochastic processes and non-local operators]]></title_en><user_id>145</user_id><user_firstLast_name>Zoran Vondraček</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2018-01</proposal_call><code>IP-2018-01-4197</code><acronim><![CDATA[DISPNOLO]]></acronim><duration>01.10.2018 - 30.09.2022</duration><status>Završio</status><financ_value>91.578,74 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Matematika, </scie_field_hr><scie_field_en>Mathematics, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>987, 635, 19068, 23258, 858435, </team_members_id><team_members_names><![CDATA[Nikola Sandrić, Vanja Wagner, Stjepan Šebek, Ivan Biočić, Indranil Chowdhury, ]]></team_members_names><keywords_hr><![CDATA[stohastički procesi sa skokovima, teorija potencijala, stohastička analiza, nelokalni operatori, semilinearne jednadžbe]]></keywords_hr><keywords_en><![CDATA[discontinuous stochastic processes, potential theory, stochastic analysis, non-local operators, semilinear equations]]></keywords_en><summary_hr><![CDATA[Mnoge slučajne pojave u životu i znanosti ne odvijaju se neprekidno u vremenu već imaju isprekidano ponašanje koje se očituje kroz iznenadne promjene stanja. Stohastički procesi sa skokovima modeliraju dinamiku takvih slučajnih evolucija. Slučaj kada evolucija zaboravlja svoju prošlost vodi do Markovljevog svojstva stohastičkog procesa. Markovljevi procesi su kroz svoje infinitezimalne generatore povezani s funkcionalnom analizom i teorijom parcijalnih diferencijalnih jednadžbi. Infinitezimalni generator Markovljevog procesa sa skokovima je nelokalni, integro-diferencijalni operator. Cilj ovog projekta je proučavanje određene klase stohastičkih procesa sa skokovima i nelokalnih operatora, pripadajuće teorije potencijala, teorije stabilnosti i veze s teorijom parcijalnih diferencijalnih jednadžbi. Preciznije, naši ciljevi su istraživanje sljedećih problema: (1)  Studirati Markovljev proces sa skokovima na omeđenom podskupu Euklidskog prostora definiran pomoću svoje jezgre skokova koja osim udaljenosti između točaka uzima u obzir i udaljenost točaka do granice podskupa. Postavljamo pitanje konstrukcije takvog procesa, te proučavamo njegovu teoriju potencijala, svojstva stabilnosti i analitička svojstva; (2) Proširiti neke dijelove teorije semilinearnih jednadžbi za eliptičke diferencijalne operatore na nelokalne operatore kao što su frakcionalni Laplaceov operator te općenitiji nelokalni operatori koji zadovoljavaju izvjesna slaba svojstva skaliranja. Konačni cilj je pronaći vjerojatnosnu interpretaciju rješenja semilinearnih jednadžbi za nelokalne operatore; (3) Primijeniti stohastičke procese sa skokovima u teoriji rizika.Metode istraživanja koje koristimo dolaze iz teorije vjerojatnosti, teorije potencijala, parcijalnih diferencijalnih jednadžbi i funkcionalne analize. Očekivani rezultat predloženog istraživanja je daljnji razvoj nekih aspekata teorije stohastičkih procesa sa skokovima i nelokalnih operatora i doprinos dubljem razumijevanju teorije. ]]></summary_hr><summary_en><![CDATA[Many random phenomena in real life and science do not evolve continuously in time, but rather have abrupt behaviour, manifested through a sudden change of states. Discontinuous stochastic processes model the dynamics of such random evolutions. The case when the evolution forgets its past leads to the Markov property of the stochastic process. Markov processes are, through their infinitesimal generators, related to functional analysis and partial differential equations. The infinitesimal generator of a discontinuous Markov process is a non-local, integro-differential operator. The goal of this project is to study certain classes of discontinuous stochastic processes and non-local operators, their potential theory and stability theory, and connection to partial differential equations. Specifically, our objectives are to investigate the following problems: (1) Study a discontinuous Markov process on a bounded subset of the Euclidean space defined through its jumping kernel which takes into account the distances of points to the boundary of the subset, as well as the distance between the points. We address the question of constructing such a process and study its potential-theoretic, analytic and stability properties; (2) Extend some parts of the theory of semilinear equations for elliptic differential operators to non-local operators such as the fractional Laplacian and more general non-local operators satisfying certain weak scaling properties and to find a probabilistic representation of solutions of semilinear equations for non-local operators; (3) Apply discontinuous stochastic processes to risk theory.The research methods we use come from probability theory, potential theory, partial differential equations and functional analysis. The expected result of the proposed research is to further develop some aspects of the mathematical theory of discontinuous stochastic processes and non-local operators and to contribute to deeper understanding of the theory. ]]></summary_en></project><project>
<id>7566</id><title_hr><![CDATA[Dialogue about Radicalisation and Equality (DARE;  725349)]]></title_hr><title_en><![CDATA[]]></title_en><user_id>3880</user_id><user_firstLast_name>Renata Franc</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-01</proposal_call><code>DOK-2018-01-1642</code><acronim><![CDATA[]]></acronim><duration>20.09.2018 - 20.12.2022</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Psihologija, </scie_field_hr><scie_field_en>Psychology, </scie_field_en><institution_hr><![CDATA[Institut društvenih znanosti Ivo Pilar]]></institution_hr><institution_en><![CDATA[Institute of Social Sciences Ivo Pilar in Zagreb]]></institution_en><team_members_id>25218</team_members_id><team_members_names><![CDATA[ Doktorand: Tomislav Pavlović ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>7569</id><title_hr><![CDATA[Ekstrakcija bioaktivnih biljnih sastavnica pomoću zelenih otapala – korak prema zelenim kozmeceuticima]]></title_hr><title_en><![CDATA[Bioactive plant principles extraction using green solvents - a step towards green cosmeceuticals ]]></title_en><user_id>4167</user_id><user_firstLast_name>Marijana Zovko Končić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2018-01</proposal_call><code>IP-2018-01-6504</code><acronim><![CDATA[CosmoGreen]]></acronim><duration>01.10.2018 - 28.02.2023</duration><status>Završio</status><financ_value>139.204,19 eur</financ_value><scie_area_hr>Prirodne znanosti, Biomedicina i zdravstvo, </scie_area_hr><scie_area_en>Natural sciences, Biomedicine and health sciences, </scie_area_en><scie_field_hr>Kemija, Farmacija, </scie_field_hr><scie_field_en>Chemistry, Pharmaceutical sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Farmaceutsko-biokemijski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Pharmacy and Biochemistry]]></institution_en><team_members_id>23855, 23854, 6966, 20361, 22753, 3925, 23856, 3915, 23972, 26076, 858443, 861756, 6482, 18925, 3946, </team_members_id><team_members_names><![CDATA[Vassilios Roussis, Efstathia Ioannou, Lovorka Vujić, Monika Barbarić, Jasna Jablan, Suzana Inić, Biljana Božin, Mario Jug, Petar Ciganović, Marina Jurić, Lejsa Jakupovic, Michal Tomczyk, Jasna Prlić Kardum, Anamarija Mitar, Marijan Marijan, ]]></team_members_names><keywords_hr><![CDATA[Anti-aging, fibroblasti, izolacija vođena bioaktivnošću, kozmeceutici, optimizacija ekstrakcije, zelena otapala]]></keywords_hr><keywords_en><![CDATA[Anti-aging, bioactivity guided isolation, cosmeceuticals, extraction optimization, fibroblasts, green solvents]]></keywords_en><summary_hr><![CDATA[Mnogobrojne biljne sastavnice mogu utjecati na različite mete u ljudskom organizmu, uključujući stanice kože i ekstracelularni matriks. Na taj način one mogu djelovati ne samo na izgled nego i na zdravlje ovog važnog organa. Zbog toga se biljni ekstrakti često koriste u izradi takozvanih &#39;&#39;kozmeceutika&#39;&#39;, proizvoda za koje se smatra da imaju značajke kozmetike i lijekova. Prirodno porijeklo sastavnica takvih proizvoda, što uključuje i aktivne i pomoćne tvari, vrlo je poželjno. Stoga bi otapala koja se koriste za ekstrakciju biljnog materijala trebala biti prirodnog porijekla, biorazgradiva i netoksična. Nadalje, postupak ekstrakcije trebao bi biti usmjeren k povećanju sadržaja aktivne tvari u ekstraktima. Također je poželjno da otapalo ne bude samo pasivni nosač aktivne tvari nego i da učinkovito povećava njezinu djelotvornost. U sklopu projekta biti će priređena serija ekstrakata kopnenih i morskih organizama. Izolirat će se njihove aktivne sastavnice te odrediti njihova struktura. Biološka aktivnost ekstrakata bit će detaljno ispitana korištenjem više enzimskih testova te ispitivanja na stanicama. Odredit će se optimalni uvjeti ekstrakcije aktivnih tvari. Rezultati projekta bit će primjenjivi u razvoju kozmetičkih i dermatoloških proizvoda. Imajući na umu da će dio biljnog materijala koji će se koristiti u istraživanju biti dobiven iz otpadne biomase, rezultati će imati značajan ekonomski i ekološki potencijal  za proizvodnju kozmetike iz obnovljivih izvora. ]]></summary_hr><summary_en><![CDATA[Numerous plant secondary metabolites can affect multiple targets in human body, including skin cells and extracellular matrix. In this way, they can influence not only look, but also overall health of this important organ. For this reason plant extracts are often part of so-called “cosmeceuticals”, products combining the principles of cosmetics and drugs. Natural origin of such products&#39; ingredients, including both the active principles and the excipients, is highly valued. Therefore, the solvent used for the extraction of plant material should be of natural origin, biodegradable and non-toxic. Furthermore, the extraction process should be aimed at increasing the content of the active ingredient in the extract. Finally, it is desirable that the solvent is not only a passive carrier of the bioactive molecule but that it effectively enhances its desired activity. In the course of the project, a series of extracts from both terrestrial and marine organisms using non-toxic solvents of natural origin will be prepared. Their active constituents will be isolated, their structure determined and the biological activity thoroughly tested using several enzyme and cellular assays. Optimal conditions for the &#39;&#39;green&#39;&#39; extraction of active principles will be determined. The findings of this project will be applicable in development of cosmetic and dermatological products. Having in mind that the part of plant material used for the extraction will be obtained from waste biomass, the results will have a significant economical and ecological potential for production of cosmetics from renewable sources.]]></summary_en></project><project>
<id>7573</id><title_hr><![CDATA[Umrežavanje glazbom: promjene paradigmi u „dugom 19. stoljeću“ – od Luke Sorkočevića do Franje Ks. Kuhača]]></title_hr><title_en><![CDATA[]]></title_en><user_id>7808</user_id><user_firstLast_name>Vjera Katalinić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-01</proposal_call><code>DOK-2018-01-8641</code><acronim><![CDATA[NETMUS19]]></acronim><duration>01.08.2018 - 01.10.2021</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Znanost o umjetnosti, </scie_field_hr><scie_field_en>Arts, </scie_field_en><institution_hr><![CDATA[Hrvatska akademija znanosti i umjetnosti]]></institution_hr><institution_en><![CDATA[Croatian Academy of Sciences and Arts]]></institution_en><team_members_id>19469</team_members_id><team_members_names><![CDATA[ Doktorand: Sara Ries ]]></team_members_names><keywords_hr><![CDATA[umrežavanje, glazba, dugo 19. stoljeće, Luka Sorkočević, Franjo Ksaver Kuhač, korespondencija, dnevnik]]></keywords_hr><keywords_en><![CDATA[networking, music, long 19th century, Luka Sorkočević, Franjo Ksaver Kuhač, correspondence, diary]]></keywords_en><summary_hr><![CDATA[Umrežavanje glazbom u „dugom 19. stoljeću“ proučavat će se komparativno na tri tematska kruga: 1) Boravak Luke Sorkočevića (1734-1789) u Beču (1781-82) i njegov dnevnik koji pruža uvid u krug istaknutih političkih, kulturnih i intelektualnih ličnosti i u sustav provođenja politike Dubrovačke Republike; 2) mapiranje dolazaka i nastupa inozemnih putujućih opernih družina i solista u Zagrebu sredinom 19. stoljeća od „prve nacionalne opere“ - Ljubavi i zlobe V. Lisinskoga (1846) do pokretanja stalne nacionalne opere u zagrebu i Zajčeva Mislava (1870); 3) obrazovna i istraživačka povezivanja F. Ks. Kuhača (1834-1911) sa skladateljima, muzikografima i melografima srednje i jugoistočne Europe kroz prizmu korespondencije te objavljene dokumentacije i njegovih radova. Uz arhivska i terenska istraživanja komparativno će se analizirati izvori sačuvani u Hrvatskoj i inozemstvu (Italija, Austrija, Mađarska, Češka, Slovačka, Poljska, Srbija, Bugarska). Istraživanja će rezultirati pojedinačnim člancima i kritičkim izdanjima Sorkočevićeva dnevnika te druge i treće knjige (1864-1872) korespondencije od 13 sačuvanih iz Kuhačeve ostavštine.]]></summary_hr><summary_en><![CDATA[Networking through music in the „long 19th century“ will be comparatively investigated within three thematic areas: 1) The sojourn of Luka Sorkočević (1734-1789) in Vienna in 1781-82 and his diary which gives insight into the circle of outstanding political, cultural and intellectual figures and into the functioning of the politics led by the Dubrovnik Republic; 2) maping of arrivals and performances of foreign itinerant opera companies and soloists in Zagreb in the mid-19th century, from „first national opera“ - Lisinski&#39;s Love and malice (1846) - to the foundation of the permanent opera ensemble in Zagreb and Zajc&#39;s opera Mislav  (1870); 3) educational and research connections of Franjo Ksaver Kuhač (1834-1911) with composers, musicographers and melographers from the central and south-eastern Europe through his correspondence and published documents and his publications. Beside archival and filed research, a comparative analyses of sources preserved in Croatia and abroad (Italy, Austria, Hungary, Czechia, Slovakia, Poland, Serbia, Bulgaria) will be conducted. The research will result with articles and critical editions of Sorkočević&#39;s diary, as well as the second and third book of correspondence (1864-1872) out of 13 preserved in the legacy F. Ks. Kuhač.]]></summary_en></project><project>
<id>7577</id><title_hr><![CDATA[Dinamička i ergodička svojstva preslikavanja na plohama]]></title_hr><title_en><![CDATA[Dynamical and ergodic properties of maps on surfaces]]></title_en><user_id>2870</user_id><user_firstLast_name>Sonja Štimac</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2018-01</proposal_call><code>IP-2018-01-7491</code><acronim><![CDATA[DEPOMOS]]></acronim><duration>01.11.2018 - 31.10.2022</duration><status>Završio</status><financ_value>85.871,66 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Matematika, </scie_field_hr><scie_field_en>Mathematics, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>5838, 740, 20035, </team_members_id><team_members_names><![CDATA[Siniša Slijepčević, Vjekoslav Kovač, Kristijan Kilassa Kvaternik, ]]></team_members_names><keywords_hr><![CDATA[Teorija tiještenja, topološka entropija, atraktor, metrička entropija, tvist difeomorfizam, ergodički teorem, Heisenbergova grupa]]></keywords_hr><keywords_en><![CDATA[The kneading theory, topological entropy, attractor, metric entropy, twist diffeomorphism, ergodic theorem, Heisenberg group]]></keywords_en><summary_hr><![CDATA[Teorija dinamičkih sustava i posebno studija kaotičnih sustava bila je jedan od važnih otkrića u znanosti 20-og stoljeća. Geometrijske i kvalitativne tehnike iz dinamičkih sustava uspješno se primijenjuju na niz važnih nelinearnih problema, od fizike i kemije do ekologije i ekonomije. Razvoj snažnih računala i kompjutorske grafike pokazao je da dinamika niskodimenzionalnih sustava može biti istodobno lijepa i komplicirana.Cilj predloženog projekta je proučavanje određenih klasa tih lijepih i kompliciranih niskodimenzionalnih kaotičnih dinamičkih sustava. Točnije, naši ciljevi su istražiti sljedeće probleme: (1) Lozijevski atraktori. Planiramo istražiti dinamička svojstva lozijevskih preslikavamnja i topološka svojstva lozijevskih atraktora. (2) Tvist difeomorfizmi na cilindru koji čuvaju površinu. Postoje brojna fundementalna ergodsko-teoretska pitanja za te klase preslikavanja koja još nisu odgovorena, posebice vezano uz jake ocjene topološke i metričke entropije te Lyapunovljevih eksponenata. Planiramo dalje razvijati varijacione metode koje adresiraju te probleme.(3) Ergodička teorija na Heisenbergovoj grupi. Namjeravamo izvesti ocjene koje daju kvantitativnu informaciju o konvergenciji po normi dvostrukih ergodičkih usrednjenja obzirom na dva toka/preslikavanja koji/koja generiraju Heisenbergovu grupu. To će biti ostvareno proučavanjem svojstava lijevo-invarijantnih tokova i pripadnih analitičkih usrednjenja na neprekidnoj Heisenbergovoj grupi, koja je već zanimljiva sama za sebe. Metode istraživanja koje namjeravamo koristiti dolaze iz ergodske teorije, simboličke i hiperboličke dinamike, teorije kontinuuma, topologije i analize. Očekivani rezultati su daljnji razvoj nekih aspekata niskodimenzionalnih dinamičkih sustava. Rezultati istraživanja bit će napisani u 10-12 radova objavljenih u vodećim svjetskim matematičkim časopisima.]]></summary_hr><summary_en><![CDATA[The theory of dynamical systems and especially the study of chaotic systems has been one of the important breakthroughs in science in the 20th century. Scientists have been able to apply the geometric and qualitative techniques from dynamical systems to a number of important nonlinear problems ranging from physics and chemistry to ecology and economics. Development of powerful computers and computer graphics has shown that the dynamics of low-dimensional systems can be at once beautiful and complicated. The goal of the proposed project is to study certain classes of these beautiful and complicated low-dimensional chaotic dynamical systems. More precisely, our objectives are as follows: (1) The Lozi-like maps. We plan to investigate dynamical properties of the Lozi-loke maps and topological properties of the Lozi-like attractors. (2) The area-preserving twist diffeomorphisms on a cylinder. There is a number of fundamental ergodic theoretical questions still unanswered for these classes of maps, in particular related to obtaining sharp bounds on topological and metric entropy and Lyapunov exponents. We plan to develop further variational techniques to address these problems. (3) Ergodic theory on the Heisenberg group. We plan to derive estimates providing quantitative information on the norm convergence of double ergodic averages with respect to two flows/maps generating the Heisenberg group. This will be achieved by investigating properties of left-invariant flows and the corresponding analytical averages on the continuous Heisenberg group, which is an interesting structure on its own. The research methods we plan to use come from ergodic theory, symbolic and hyperbolic dynamics, continua theory, topology and analysis. The expected results are to further develop some aspects of the low-dimensional dynamical systems. The results of the research will be written in 10 – 12 papers published in leading international mathematical journals.]]></summary_en></project><project>
<id>7579</id><title_hr><![CDATA[Svjetlo na molekulama: istraživanje spregnute elektronske i nuklearne dinamike]]></title_hr><title_en><![CDATA[]]></title_en><user_id>2848</user_id><user_firstLast_name>Nađa Došlić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-01</proposal_call><code>DOK-2018-01-4034</code><acronim><![CDATA[LightMol]]></acronim><duration>05.09.2018 - 04.12.2022</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, </scie_field_hr><scie_field_en>Chemistry, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>25276</team_members_id><team_members_names><![CDATA[ Doktorand: Tomislav Piteša ]]></team_members_names><keywords_hr><![CDATA[neadijabatska dinamika, fotoelektronska spektroskopija, DNA, mikrosolvatacija, višekromoforni sustavi]]></keywords_hr><keywords_en><![CDATA[nonadiabatic dynamics, photoelectron spectroscopy, DNA, microsolvation, multichromophore systems]]></keywords_en><summary_hr><![CDATA[Mogućnost praćenja elektronskih i strukturnih transformacija kroz koje molekulski sustav prolazi nakon apsorpcije svjetla je dugo sanjani san. Njegovo je ostvarenje moguće samo kombinacijom teorijskih i eksperimentalnih istraživanja.  Nove spektroskopijske tehnike temeljene na interakciji s visokofrekventnim zračenjem dopuštaju istraživanje molekulske strukturne dinamike na dosad neviđenoj razini detaljnosti.  Posebno se vremenski razlučena fotoelektronska spektroskopija (TRPES) etablirala kao vodeća tehnika u tom polju. Međutim, interpretacija TRPES eksperimenata zahtijeva naprednu razinu teorije. Teorijske metode za računanje TRPES opservabli moraju biti dovoljno točne da se može uspostaviti izravna veza između strukture molekule i eksperimentalne opservable. One također moraju biti efikasne, jer simulacija vremenski razlučenih eksperimenata zahtijeva račune za stotine ili čak za tisuće molekulskih gemoetrija. Ciljevi ovog projekta su (i) poboljšanje numeričke efikasnosti računanja fotoionizacijskih opservabli. Naš cilj je učiniti vrijeme potrebno za računanje vrlo točnih udarnih presjeka i parametara asimetrije usporedivim s vremenom računanja dinamike u pobuđenim stanjima.;(ii) razvoj metoda za pouzdanije simulacije nedijabatske molekulske dinamike. To se prvenstveno odnosi na uključivanje u simulacije nuklearnih kvantnih efekata. Relaksacija pobuđenih stanja u biomolekulama često odvija  eliminacijom vodika kojeg simulacije neadijabatske dinamike često “ne vide” .(iii) poboljšanje numeričke efikasnost simulacija neadijabatske molekulske dinamike prijenosom dijela računa na grafičke procesore (GPU). To će nam omogućiti istraživanje dinamike složenih  struktura kao što su hidratirane nukleobaze, vertikalno i horizontalno povezane DNA baze.Mišljenja smo da uz korištenje naprednih algoritamskih tehnika ostvarenje sna i nije tako daleko.]]></summary_hr><summary_en><![CDATA[The possibility to follow the electronic and structural transformations that a molecular system undergoes after light absorption is a long-standing dream. The realization of this dream is possible only through a joint theoretical and experimental effort. New spectroscopic techniques based on interaction with high frequency radiation permit the investigation of molecular structural dynamics at an unprecedented level of detail. In particular, time-resolved photoelectron spectroscopy (TRPES) has emerged as the leading technique in this field. However, the interpretation of TRPES experiments requires advanced theory. Theoretical methods for calculating TRPES observables need to be accurate, so that a direct link between the structure of a molecule and the experimental observable can be established. They also need to be efficient because the simulation of time-resolved experiments requires calculations to be performed for hundreds or even thousands of molecular geometries. In order to meet these conditions, which are at the very heart of this project, advances on several fronts will be made: (i) we will improve the numerical efficiency of the computation of photoionization observables. Our goal is to make the numerical effort required for the computation of very accurate cross sections and asymmetry parameters comparable to the one for the computation of the excited state dynamics; (ii) better-quality methods for nonadiabatic molecular dynamics will be developed by the inclusion of nuclear quantum effects in simulations; (iii) we will improve the numerical efficiency of nonadiabatic molecular dynamics simulations by porting part of the calculation to graphical processor units (GPU). This will allow us to explore the dynamics of complex structures such as hydrated nucleobases, stacked and paired DNA bases.We feel that with advanced algorithmic techniques the dream is not so far away.]]></summary_en></project><project>
<id>7580</id><title_hr><![CDATA[Anisakis kao kancerogen: Izazov rušenja Lancetovog mita ili otkrivanje prave istine]]></title_hr><title_en><![CDATA[Anisakis as a carcinogen: Daring to bust Lancet&#39;s myth or revealing its true colours]]></title_en><user_id>132</user_id><user_firstLast_name>Ivona Mladineo</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2018-01</proposal_call><code>IP-2018-01-8490</code><acronim><![CDATA[AnisCar]]></acronim><duration>01.04.2019 - 31.03.2023</duration><status>Prekinut</status><financ_value>199.084,21 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Veterinarska medicina, </scie_field_hr><scie_field_en>Veterinary medicine, </scie_field_en><institution_hr><![CDATA[Institut za oceanografiju i ribarstvo]]></institution_hr><institution_en><![CDATA[Institute of Oceanography and Fisheries]]></institution_en><team_members_id>23685, 23713, 19279, 4601, 23767, 13683, 23921, 1238, 1127, 28773, 5343, </team_members_id><team_members_names><![CDATA[Concetta Maria Messina, Binh Dang Thuy, Violeta Šoljić, Mirela Petrić, Anamarija Vrbatović, Jerko Hrabar, Igor Azinovic, Diana Nonković, Vedran Poljak, Tina Pavelin, Svjetlana  Cvjetan Čutura, ]]></team_members_names><keywords_hr><![CDATA[Anisakis pegreffii, kancerogenost, zoonoza, nametnik, CTA]]></keywords_hr><keywords_en><![CDATA[Anisakis pegreffii, carcinogenicity, zoonosis, parasite, CTA]]></keywords_en><summary_hr><![CDATA[AnisCar obuhvaća temeljna istraživanja usmjerena prema otkrivanju kancerogenog potencijala ličinke zoonotičnog oblića Anisakis u ljudi. Danas je poznato da je više od 20% bolesti raka u zemljama u razvoju uzrokovano infekcijama, ali je manje poznata činjenica da infekcija helmintima može imati slične posljedice. Međunarodna agencija za istraživanje raka (IARC) zasada smatra da su jedino tri vrste metilja odgovorne za izazivanje raka u ljudi: Schistosoma haematobium, Opisthorchis viverrini i Clonorchis sinensis. Pred gotovo tri desetljeća prestižni časopis Lancet je objavio rad u kojem se spekuliralo o mogućnosti da pripadnici roda Anisakis mogu djelovati kao potencijalni kancerogeni, dok se tek u nekoliko nedavnih studija dokazala kolokalizacija raka probavila i infektivne Anisakis ličinke. Iako još uvijek nije razjašnjeno jesu li dvije etiologije, anisakijaza i karcinom, povezane ili slučajna pojava, u svim opisanim slučajevima je zapaženo da neoplazija i ličinka dijele područje zahvaćeno kroničnom upalom. Nadalje, nekoliko opreznih pokušaja interpretacije interakcije između Anisakisa i stanica domaćina je potaklo ideju da kronična infekcija ličinkom može biti okidač za intestinalnu kancerogenezu. Nastavljajući se na prethodni HRZZ projekt, cilj AnisCar je rasvijetliti mehanizme toksičnog i kancerogenog potencijala Anisakis ličinke u in vivo i in vitro mišjem modelu, u usporedbi s dva poznata kancerogena, azijskim metiljima O. viverrini i C. sinensis. Metodologija obuhvaća izolaciju ukupnih proteina iz tri vrste nametnika, određivanje njihove citotoksičnosti u BALB/c 3T3 mišjim fibroblastima, tesiranje potencijala transformacije BALB/c 3T3 stanica, te konačno dokazivanje tumorskog rasta u miševa nakon aplikacije BALB/c 3T3 transformiranih stanice. Ova saznanja će utjecati na osnove parazitologije pružajući uvid u nove osobine oblića, te će dati na važnosti i težini ovoj bolesti koja se kod ljudi često pogrešno dijagnosticira i slabo prijavljuje na području Europe. ]]></summary_hr><summary_en><![CDATA[AnisCar is a fundamental research directed toward better understanding of carcinogenic potential of zoonotic nematode larvae Anisakis in men. Today more than 20% of cancers in the developing world are caused by infections, but less perceived is the fact that infection with helminths can have similar consequences. The International Agency for Research on Cancer so far considers only three species of trematodes, Schistosoma haematobium, Opisthorchis viverrini and Clonorchis sinensis, responsible for helminth-induced human cancer. Almost three decades ago, prestigious journal Lancet published a view speculating on the possibility that Anisakis could also act as potential carcinogen, and only recently a number of studies have co-localised intestinal cancers and Anisakis larvae. Even though it is still unclear if two aetiologies, anisakiasis and carcinoma are related or just accidental incidence, all reported cases observed neoplasia and embedded larvae sharing the common site affected by chronic inflammation. In addition, a few timid assessments of Anisakis-host cells interactions encouraged the idea that chronic larval infection could represent a trigger for intestinal carcinogenesis. Capitalising on previous HRZZ project, AnisCar objective is to divulge mechanisms of Anisakis toxic and carcinogenic potential in vivo and in vitro mouse model, in relation to two known helminth carcinogens, Asian trematodes O. viverrini and C. sinensis. Methodology encompasses the isolation of crude extracts from three parasites; determination of its cytotoxicity in BALB/c 3T3 fibroblast mice cells; testing of transformation potential of BALB/c 3T3 cells; and finally evidencing tumour growth in mice after application of BALB/c 3T3 transformed cells. Contributing with this knowledge, we will affect the fundamental parasitology by gaining insight in new traits of nematodes and contribute to seriousness of the disease that in men throughout the Europe is misdiagnosed and underreported.]]></summary_en></project><project>
<id>7581</id><title_hr><![CDATA[Umjetnost i država u Hrvatskoj od prosvjetiteljstva do danas]]></title_hr><title_en><![CDATA[Art and the State in Croatia from the Enlightenment to the Present]]></title_en><user_id>3499</user_id><user_firstLast_name>Dragan Damjanović</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2018-01</proposal_call><code>IP-2018-01-9364</code><acronim><![CDATA[ASCEP]]></acronim><duration>15.10.2018 - 14.04.2023</duration><status>Završio</status><financ_value>79.633,69 eur</financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Povijest umjetnosti, </scie_field_hr><scie_field_en>Art history, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Filozofski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Humanities and Social Sciences]]></institution_en><team_members_id>4794, 23503, 23689, 4206, 4195, 23276, 23484, 4143, 4446, 4416, 4554, 4475, 23485, 23307, 865209, </team_members_id><team_members_names><![CDATA[Frano Dulibić, Ivan Kokeza, Matea Brstilo Rešetar, Sandi Bulimbašić, Zvonko Maković, Jasmina Nestić, Patricia Počanić, Željka Miklošević, Lovorka Magaš Bilandžić, Silvija Lučevnjak, Jasminka Najcer Sabljak, Sanja  Zadro, Marina Bregovac Pisk, Josipa Alviž, Sanja Delić, ]]></team_members_names><keywords_hr><![CDATA[umjetnost, država, baština, politika, obrazovanje, muzeji, povijest umjetnosti, moderno i suvremeno doba]]></keywords_hr><keywords_en><![CDATA[state, art, heritage, politics, education, museums, history of art, late modern and contemporary period]]></keywords_en><summary_hr><![CDATA[Cilj je projekta Umjetnost i država u Hrvatskoj od prosvjetiteljstva do danas istražiti utjecaje koje su državne strukture vlasti imale na umjetničku produkciju te na interpretaciju umjetničkih djela i baštine.Budući da je hrvatski politički i kulturni prostor u promatranom razdoblju od kraja 18. stoljeća do osamostaljenja Hrvatske 1991., bio u sastavu raznih država (Habsburške, odnosno Austro-Ugarske Monarhije, prve i druge Jugoslavije, Kraljevine Italije, Nezavisne Države Hrvatske) istraživači na projektu pokušat će pokazati kako, koliko (i da li je) promjena državnih okvira utjecala na odnose prema umjetničkoj produkciji te kulturnoj i obrazovnoj politici uopće u polju vizualnih umjetnosti.Zbivanja u hrvatskoj umjetnosti nastojat će se kontekstualizirati sa situacijom u susjednim zemljama, odnosno s područjima kojima je Hrvatska politički pripadala te stoga uključuje brojna terenska, arhivska, muzejska i bibliotečna istraživanja. Istraživački ciljevi unutar projekta mogu se podijeliti u dvije osnovne skupine – istraživanje utjecaja države na sva polja likovnog stvaralaštva putem narudžbi, subvencija i kontrole nad umjetničkom produkcijom, te istraživanje utjecaja države na procese stvaranja i očuvanja umjetničke baštine kao i na formalno i neformalno obrazovanje u području likovnih umjetnosti.Uz voditelja u projekt je uključeno 14 istraživača, od kojih je 8 u statusu doktoranda ili postdoktoranda kojima je ovaj projekt od osobite važnosti za daljnju izgradnju znanstvenih karijera. Uključivanjem istraživača iz baštinskih institucija (muzeja, konzervatorskih odjela) nastojat će se produbiti međuinstitucionalna suradnja i omogućiti višedimenzionalno sagledavanje složenih odnosa države prema umjetnosti.Rezultate projekta predstavljat će radovi u časopisima, knjige, zbornici, katalozi i druge publikacije, izložbe, izlaganja na znanstvenim skupovima, a članovi projekta namjeravaju organizirati i dva znanstvena skupa te radionicu.]]></summary_hr><summary_en><![CDATA[The project Art and the State in Croatia from the Enlightenment to the Present aims to explore influences of the state regime on art production and interpretation of artworks and artistic heritage.Since the Croatian cultural and political space in the period from the late 18th century to 1991 formed part of different states (Austro-Hungarian Empire, first and second Yugoslavia, Independent State of Croatia, Kingdom of Italy), the project researchers will attempt to show the degree and nature of the impact the state-based bodies exerted on artistic production and cultural and educational policies related to visual arts.Croatian art will be contextualized with artistic developments in the neighboring countries or the areas of political association with Croatia, due to which the implementation of the project entails numerous field researches (urban space, museums, libraries, archives).In terms of its goals, the project is divided into two major groups of activities – research on the impact of the state on different areas of artistic production through commissions, grants and censorship, and the impacts on the process of artistic heritage production and care and on formal and informal education in the field of visual arts.In addition to the principal investigator the project includes 14 researchers (2 doctoral students and 6 postdoctoral researchers) for whom this project presents an opportunity for academic career development. By engaging researchers from heritage institutions (museums and conservation departments), the project contributes to the promotion of inter-institutional cooperation and ensures multidimensional views on intricate relationships between art and the state.Project results will be published in journals, books, proceedings, catalogues and the like, as well as through exhibitions and conferences. The team plans to organize two project-related scientific conferences and a workshop.]]></summary_en></project><project>
<id>7582</id><title_hr><![CDATA[Književne revolucije]]></title_hr><title_en><![CDATA[Literary Revolutions]]></title_en><user_id>19523</user_id><user_firstLast_name>Marina  Protrka Štimec</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2018-01</proposal_call><code>IP-2018-01-7020</code><acronim><![CDATA[LIRE]]></acronim><duration>12.11.2018 - 11.05.2023</duration><status>Završio</status><financ_value>27.745,57 eur</financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Filologija, Interdisciplinarne humanističke znanosti, </scie_field_hr><scie_field_en>Philology, Interdisciplinary humanities, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Filozofski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Humanities and Social Sciences]]></institution_en><team_members_id>5581, 6591, 23960, 19189, 19165, 27498, </team_members_id><team_members_names><![CDATA[Zrinka Božić Blanuša, Aleksandar Mijatović, Ana Tomljenović, Zvonimir Glavaš, Andrea Milanko, Mirela Dakić, ]]></team_members_names><keywords_hr><![CDATA[književnost, revolucije, avangarda, književni kanon, estetska autonomija, emancipacija, zajednica]]></keywords_hr><keywords_en><![CDATA[literature, revolutions, Avangarde, literary canon formation, esthetic autonomy, emantipation, community]]></keywords_en><summary_hr><![CDATA[Projektom će se istraživati naslijeđe avangarde u književnom i društvenom polju, složena međuovisnost estetske autonomije i emancipacijskih praksi. Taj će se problemski sklop analizirati s obzirom na: 1. plan na kojemu se književnost odvija (poetički, estetički, politički, ideološki), 2. logiku temporalnosti – odnos prema prošlosti i tradiciji, 3. ideologiju – građansku, nacionalne narative i projekte političkih zajednica, te na 4. dominantni tip racionalnosti, tj. prevladavajuće simboličke prakse.U prvom koraku ćemo nastaviti tradiciju istraživanja avangarde kao književnopovijesnog fenomena, ali tako da je kritički promotrimo u svjetlu novih metodologija i pristupâ te u širem srednjoeuropskom i južnoslavenskom kontekstu. Cilj projekta je razviti temeljna znanja – teorijsku i metodološku paradigmu za razumijevanje i analizu koncepta književnih revolucija, utemeljenih u estetskoj autonomiji književnosti. Ispitat ćemo kako su revolucije, Francuska i Oktobarska, generirale promjene u književnom polju i kako je književno polje odredilo razumijevanje političkih pojmova zajednice i povijesnih procesa.  Pri tome ćemo identificirati pretpostavke koje su omogućile avangardnu književnu revoluciju te opisati tekstualnu mrežu simboličkih i političkih praksi koje zajednički tvore revolucionarni, emancipatorski potencijal književnosti, posebno kanonskih autora „malih“ književnosti poput hrvatske čiji je status dodatno složen i slabo istražen zbog političkih otpora koji su se vodili na književnom polju, odvraćajući pozornost istraživača s otpora forme (Krleža, Begović, Desnica). Istražit ćemo kako se prema dominantnim tekstualnim strategijama odnosi subverzivno „žensko pismo“ (Cixious), po definiciji manjinsko, a kako feministička teorija i književna kritika, a posebno ona nastala na psihoanalitičkim temeljima. Istraživačke aktivnosti rezultirat će  teorijskom i metodološkom platformom za istraživanje avangarde te novim opisom poetike kanonskih autora hrvatskog modernizma.]]></summary_hr><summary_en><![CDATA[The research project will investigate the avant-garde literary and social legacy, with special emphasis on its intricate interrelations between aesthetic autonomy and emancipation practices, to be analyzed with respectto: i) the emergence of literature and its spheres of influence (poetic, aesthetic, political and ideological); ii) a particular logic of temporality, i.e. how newly emerged literature relates to its past and tradition; iii) ideology, i.e. national narratives, political communities, and citizenship; iv) the dominant mode of rationality, i.e. prevalent symbolic practices.Innovation in approach is in critical examination of literary avant-garde in the light of contemporary methodologies and approaches, as well as in taking a wider context into consideration (Central European and South Slavic). This will help develop fundamental knowledge, i.e. theoretical and methodological paradigm for understanding and analysis of literary revolutions with their basis in the idea of aesthetic autonomy. We will be focusing on how the French and October Revolutions induced changes in literary field and how literary field marked out the understanding of political notions. Special attention will be paid to the status of &#39;&#39;minor&#39;&#39;literature such as Croatian, even more complex and critically underexamined case due to political resistance that took place on literary field, diverting interest of literary scholars and critics from the resistance of form (Krleza, Begovic, Desnica). We will also encompass &#39;&#39;écriture féminine&#39;&#39; (Cixous), by definition minor and subversive, how it positions itself towards the patriarchal yet dominant textual strategies and concepts, along with feminist literary theory and criticism, especially its he latter&#39;s psychoanalytically informed branch. All this will offer an innovative description of poetics of canonical writers of Croatian modernity and invention of a theoretical and methodological study platform for critical research of the avant-garde.]]></summary_en></project><project>
<id>7584</id><title_hr><![CDATA[Zemljovid atomskih jezgara - neutronski bogata strana]]></title_hr><title_en><![CDATA[Neutron Rich Side of the Nuclear Landscape]]></title_en><user_id>166</user_id><user_firstLast_name>Suzana Szilner</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2018-01</proposal_call><code>IP-2018-01-1257</code><acronim><![CDATA[NeRiS-Land]]></acronim><duration>01.12.2018 - 30.05.2024</duration><status>Završio</status><financ_value>191.253,57 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, </scie_field_hr><scie_field_en>Physics, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>255, 414, 4019, 163, 185, 193, 21303, 23001, 257, 865037, 865036, </team_members_id><team_members_names><![CDATA[Mile Zadro, Neven Soić, Matko Milin, Igor Gašparić, Milivoj Uroić, Deša Jelavić Malenica, Nikola Vukman, Deni Nurkić, Tea Mijatović, Luka Palada, Josipa Diklić, ]]></team_members_names><keywords_hr><![CDATA[struktura atomskih jezgara, nuklearne reakcije, nukleonske korelacije, sparivanja nukleona, nuklearni klasteri]]></keywords_hr><keywords_en><![CDATA[nuclear structure, nuclear reactions, neutron-rich nuclei, nucleon-nucleon correlations, nuclear pairing, nuclear clustering]]></keywords_en><summary_hr><![CDATA[Vrlo nedavno opažanje spajanja dvaju neutronskih zvijezda, koje nedvojbeno povezuje konkretan astronomski događaj s proizvodnjom teških elemenata, pobudilo je posebnu pažnju nuklearnih i astrofizičkih zajednica. Doprinosi u vidu novih nuklearnih podataka nužni su, uz poznavanje zvjezdanih parametara, za razumijevanje podrijetla elemenata u svemiru i određivanje stvarnog puta odvijanja procesa brzog neutronskog uhvata u karti nuklida, kao i eksplozivne nukleosinteze lakih jezgara. Predloženi projekt ima za cilj rješavanje ključnih nepoznanica na neutronskoj strani nuklearnog zemljovida upotrebom specijaliziranih akceleratorskih postrojenja i unaprijeđenih detektorskih sustava velikih dimenzija u prikupljanju visoko-kvalitetnih podataka, a uz fokus na metode produkcije jezgara bogatih neutronima i pobuđivanja egzotičnih nuklearnih struktura. Novi podaci poslužit će i za testiranje naprednih teorijskih modela i time unaprijediti razumijevanje nuklearne interakcije i još uvijek neutvrđene veze između nuklearne strukture i dinamike s teorijom jake nuklearne sile koja veže neutrone i protone.Najveći dio predloženih mjerenja izvršit će se na vrhunskim međunarodnim akceleratorskim postrojenjima za stabilne i radioaktivne ionske snopove, korištenjem najsuvremenijih detekcijskih sustava. U prikladnim slučajevima mjerenja će se provoditi i na ubrzivačima IRB-a. Ovaj projekt ujedinjuje hrvatsku zajednicu eksperimentalnih niskoenergijskih nuklearnih fizičara i jača njen položaj na karti europske nuklearne fizike. Znanstvenici koji sudjeluju u projektu bili su glasnogovornici brojnih eksperimenata na međunarodnim postrojenjima, imaju veliko iskustvo u nuklearnim eksperimentalnim istraživanjima i značajan međunarodni ugled. Konačno, ovaj je projekt posve usklađen sa strateškim dokumentom dugoročnog plana ekspertne komisije za nuklearnu fiziku Europske znanstvene zaklade.]]></summary_hr><summary_en><![CDATA[The very recent observation of a merger of two neutron stars, which has unambiguously connected an astronomical event with the production of heavy elements, is presently receiving a distinctive attention of the nuclear and astrophysics community. In order to understand the origin of elements in the Universe, besides stellar parameters, inputs from nuclear physics are indispensable to define the actual path of the rapid neutron capture of heavy-mass and explosive synthesis of low-mass nuclei. The proposed project aims to address key unknowns at the neutron-rich side of the nuclear landscape by exploiting dedicated accelerator facilities and improved large-scale detection systems in acquisition of a new high quality data, focusing on the methods of  production of neutron-rich nuclei and on excitation of exotic nuclear structures. New informations will benchmark recent advanced theoretical models and thus progress the present understanding of nuclear interaction and the still missing link between the nuclear structure and dynamics and the theory of strong interaction which binds neutrons and protons.The major part of the proposed experimental work will be performed at the top international accelerator facilities for stable and radioactive ion beams by using state-of-the-art detection systems. In the well suited cases, the measurements will also be performed at the RBI accelerators. This project consolidates the Croatian community of experimental low-energy nuclear physicists and strengthens its position on the map of European nuclear physics. Senior scientists involved in this project were spokespersons of numerous experiments at international facilities, have a great experience in nuclear experimental research and a considerable international reputation. Finally, this project nicely matches the strategic community document Long Range Plan of the Nuclear Physics European Collaboration Committee of European Science Foundation.]]></summary_en></project><project>
<id>7585</id><title_hr><![CDATA[Regulacija GLI koda u tumorima ovisnim o BRAF/NRAS mutacijama]]></title_hr><title_en><![CDATA[Differential regulation of the GLI code in BRAF/NRAS driven tumors]]></title_en><user_id>19584</user_id><user_firstLast_name>Maja Sabol</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2018-01</proposal_call><code>IP-2018-01-4889</code><acronim><![CDATA[GLIcode]]></acronim><duration>01.01.2019 - 31.12.2022</duration><status>Završio</status><financ_value>132.464,53 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>23741, 942, 712, 1033, 23840, 13676, 28631, 27627, 864899, 865071, </team_members_id><team_members_names><![CDATA[Nenad Bartoniček, Vesna Musani, Petar Ozretić, Diana Trnski, Sanja Poduje, Majda Vučić, Nikolina Rinčić, Matea Kurtović, Tina Petrić, Josipa Čonkaš, ]]></team_members_names><keywords_hr><![CDATA[Signalni put Hedgehog, BRAF, NRAS, melanom, GLI]]></keywords_hr><keywords_en><![CDATA[Hedgehog signaling, BRAF, NRAS, melanoma, GLI]]></keywords_en><summary_hr><![CDATA[Signalni put Hedgehog povezan je s nastankom raznih tumora, ali točni mehanizmi djelovanja još nisu u potpunosti razjašnjeni. Fokus ovog istraživanja su tumori s mutacijama u genima BRAF ili NRAS, te njihov odgovor na inhibiciju signalnog puta Hedgehog. BRAF i NRAS nekanonički aktiviraju sva tri proteina GLI, ali točan slijed i djelovanje ovih interakcija još nisu razjašnjeni. Ovim projektom planiramo odrediti točne transkripcijske mete proteina GLI1, GLI2 i GLI3 u melanomima s različitim genetičkim podlogama: mutacijom u BRAF, mutacijom u NRAS, ili bez mutacije u ova dva gena. Stoga ćemo prvo provesti analizu ChIP-seq kako bismo odredili točne transkripcijske mete ovih proteina. Nakon toga uklonit ćemo gene za svaki od tih proteina („knock-out“) i sekvencirati transkriptome tih staničnih linija. Nakon izrade „knock-out“ linija, testirat ćemo ih nizom testova kako bismo odredili ulogu svakog od tri proteina GLI u tumorima ovisnim o BRAF/NRAS mutacijama, te kako bismo razjasnili mehanizam njihovog djelovanja u melanomima. Kombiniranim tretmanima inhibitorima signalnog puta Hedgehog i specifičnim inhibitorima BRAF/NRAS, te izradom i testiranjam staničnih linija otpornih na te lijekove, pokazat ćemo postoji li pozitivan učinak za potencijalno liječenje melanoma. Sve ove analize pokazat će nam mogu li se proteini GLI ili njihovi ciljni geni koristiti kao potencijalni biomarkeri za melanom. Na kraju, u zadnjoj godini projekta, analizirat ćemo set kliničkih uzoraka na te potencijalne biomarkere, kako bismo procijenili njihovu moguću primjenu u klinici. Ukratko, ovim projektom u planu je kompletna analiza GLI koda u melanomima ovisnim o BRAF/NRAS mutacijama, od određivanja transkripcijskih meta i pronalaženja molekularnih mehanizama do potencijalne primjene u klinici.]]></summary_hr><summary_en><![CDATA[The Hedgehog signaling pathway has been implicated in development of various tumors, but the exact roles and molecular mechanisms are still not understood. The focus of this research are the tumors harboring BRAF of NRAS mutations, and their differential response to Hedgehog pathway inhibition. Both BRAF and NRAS non-canonically activate the three GLI proteins, but the activity and interplay of this interaction in still unclear. With this project we propose to determine the exact transcriptional targets of GLI1, GLI2 and GLI3 proteins in melanoma with different genetic backrounds, either harboring a BRAF mutation, a NRAS mutation, or no mutation in these two genes. For this purpose, we will first perform ChIP-seq to determine the transcriptional targets, then knock-out each of the three GLI proteins and sequence the transcriptomes of the knock-out cell lines. After the knock-outs have been generated, a series of cell assays will be performed to determine to role of each of the three GLI proteins in BRAF/NRAS dependant tumors, and to elucidate the mechanism of their action in melanoma. Combined treatments with Hedgehog inhibitors and specific BRAF/NRAS inhibitors, followed by generation and testing of resistant cell lines, will demonstrate if there is a potential benefit in the clinical management of melanoma. All these analyses will demonstrate whether GLI proteins or their transcriptional targets can be used as potential biomarkers for melanoma. Finally, in the final year of the project, a set of clinical samples will be analyzed for these potential biomarkers to determine their possible use in the clinic. In summary, this project plans a complete analysis of the GLI code in BRAF/NRAS dependant melanoma, from determining the transcriptional targets and finding molecular mechanisms, to potential translation to the clinic.]]></summary_en></project><project>
<id>7589</id><title_hr><![CDATA[Razvoj integriranog mikrosustava za biokatalitičku proizvodnju biodizela]]></title_hr><title_en><![CDATA[]]></title_en><user_id>7049</user_id><user_firstLast_name>Bruno Zelić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-01</proposal_call><code>DOK-2018-01-5527</code><acronim><![CDATA[DeMSy(BioPro)2]]></acronim><duration>17.09.2018 - 16.09.2022</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Kemijsko inženjerstvo, </scie_field_hr><scie_field_en>Chemical engineering, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet kemijskog inženjerstva i tehnologije]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Chemical Engineering and Technology]]></institution_en><team_members_id>25366</team_members_id><team_members_names><![CDATA[ Doktorand: Martin Gojun ]]></team_members_names><keywords_hr><![CDATA[biodizel, enzim lipaza, pročišćavanje, mikroreaktor, integrirani proces]]></keywords_hr><keywords_en><![CDATA[biodiesel, lipase, purification, microreactor, integrated process]]></keywords_en><summary_hr><![CDATA[U današnje vrijeme kada se raspoloživost i dostupnost fosilnih goriva značajno smanjuje, potreba za proizvodnjom biogoriva iz različitih obnovljivih izvora je sve izraženija. Biorazgradivost, netoksičnost i mala emisija štetnih tvari samo su neka od svojstava koja čine biodizel ekološki prihvatljivijim gorivom. Cilj ovog projekta je razviti integrirani mikrosustav za biokatalitičku proizvodnju biodizela. U tu svrhu će se proizvesti biokatalizator, enzim lipaza podrijetlom iz gljive Thermomyces lanuginosus fermentacijom na čvrstom otpadu prehrambene industrije kao supstrat, sintetizirati biodizel transesterifikacijom u kotlastom bioreaktoru i različitim mikroreaktoriskim sustavima korištenjem komercijalno dostupne i lipaze proizvedene fermentacijom na čvrstim nosačima pomoću gljive T. lanuginosus, provesti separaciju glicerola u prvoj fazi i pročišćavanje dobivenog biodizela u drugoj fazi primjenom membranske ultrafiltracije na modulima sa šupljim vlaknima kako bi proizvedeni biodizel kvantitativno i kvalitativno zadovoljio propisane norme. Kao supstrat u procesu transeterifikacije koristit će se svježe i otpadno jestivo ulje, a rezultati pokusa provedenih u različitim reaktorskim konfiguracijama će se usporediti kako bi se izabrao najpogodniji reakcijski sustav. Po prvi puta razvit će se integrirani mikroreaktorski sustav koji će na jednom čipu omogućiti kontinuiranu proizvodnju biodizela dok će se na drugom čipu odvijati kontinuirana separacija i pročišćavanje biodizela korištenjem filtera integriranih u sustav. Osim provedbe pokusa posebna pozornost će se posvetiti i razvoju matematičkog modela procesa proizvodnje biodizela u mikroreaktoru. Razvit će se 2D i 3D matematički model procesa, a rezultati simulacije matematičkog modela procesa koristit će se u svrhu boljeg razumijevanja strujanja reakcijske smjese u mikrokanalu, optimizacije procesa i uvećanja procesa.]]></summary_hr><summary_en><![CDATA[Nowadays as the availability and accessibility of fossil fuels is significantly declining, the need for the production of biofuels from various renewable sources is becoming increasingly interesting. Biodegradability, non-toxicity and low pollution emissions are merely some properties making biodiesel a more environmentally friendly fuel. The aim of this project is to develop an integrated microsystem for the biocatalytic production of biodiesel. For this purpose: (i) an enzyme lipase from the fungus Thermomyces lanuginosus will be produced on solid waste from food industry, (ii) biodiesel will be produced using transesterification reaction in a stirred-tank bioreactor and different microrector systems utilising a commercially available lipase and a lipase produced by solid-state fermentation using the fungus T. lanuginosus, (iii) separation of glycerol will be carried out in the first phase and purification of the obtained biodiesel in the second phase applying  the membrane ultrafiltration modules with hollow fibres to produce biodiesel that quantitatively and qualitatively fulfils the prescribed standards. Fresh and waste cooking oil will be used as a substrate in the transesterification process. The results of the experiments conducted in different reactor configurations will be compared in order to select the most appropriate reaction system. For the first time, an integrated microreactor system will be developed. The continuous production of biodiesel will take place in a single chip, while another chip will be used for continuous separation and purification of biodiesel using a filter integrated into the system. Special attention will be paid to the development of mathematical models for biodiesel production in a microreactor. 2D and 3D mathematical models will be developed for the processes and the results of mathematical model simulations will be used to better understand the flow of the reaction mixture, process optimization and process scale up.]]></summary_en></project><project>
<id>7590</id><title_hr><![CDATA[Imunosni mehanizmi u razvoju upale i metaboličkog sindroma u debljini]]></title_hr><title_en><![CDATA[]]></title_en><user_id>7082</user_id><user_firstLast_name>Bojan Polić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-01</proposal_call><code>DOK-2018-01-5814</code><acronim><![CDATA[INFLAMETAB]]></acronim><duration>02.07.2018 - 01.10.2022</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Temeljne medicinske znanosti, </scie_field_hr><scie_field_en>Basic Medical Sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Rijeci, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Rijeka, Faculty of Medicine]]></institution_en><team_members_id>25199</team_members_id><team_members_names><![CDATA[ Doktorand: Ante Benić ]]></team_members_names><keywords_hr><![CDATA[Upala, Debljina, Rezistencija na inzulin, metabolički sindrom, diabetes, NASH,  stanice NK, urođeni limfociti, gamma delta limfociti T, citokini]]></keywords_hr><keywords_en><![CDATA[Inflammation, Obesity, Insuline resistance, Metabolic Syndrome, diabetes, NASH, NK cells, ILCs, gamma delta T cells, macrophages, cytokines]]></keywords_en><summary_hr><![CDATA[Pretilost je jedan od najznačajnijih i rastućih medicinskih zdravstvenih problema današnjice. Procjenjuje se da trenutno na svijetu živi više od pola milijarde debelih ljudi i  preko milijarde onih s prekomjernom težinom. Značajan broj njih oboljeva od šećerne bolesti tipa 2 (DM2) i nealkoholne bolesti masne jetre (NAFLD), koje često koegzistirjau i dijele patogene abnormalnosti debljine kao što su rezistencija na inzulin (IR), dislipidemija i hipertenzija, što su karakteristike metaboličkog sindroma. Debljina je povezana sa kroničnom sistemskom upalom niskog intenziteta za koju se smatra da je važan pozadinski uzrok IR, koja dovodi do DM2 i NAFLD. Ciljanje mehanizama upale u obje bolesti je stoga obećavajuće za buduće pristupe u terapiji. No, stvarni mehanizmi koji induciraju ili pogoršavaju upalu u debljini i uzrokuju prijelaz iz stadija pre-dijabetesa u DM2 ili iz stadija jetrene steatoze u nealkoholni steatohepatitis (NASH) su još uvjek uglavnom nejasni. Stoga je bolje poznavanje imunosnih uzroka DM2-a i NASH-a neophodno potrebno. U ovom projektu namjeravamo istražiti imunosne mehanizme koji su važni za indukciju upalnih procesa u visceralnom masnom tkivu (VAT) i jetri, te su odgovorni za razvoj DM2 i NASH. Dodatno, naš cilj je istražiti virusne faktore koji pogoršavaju IR i imaju učinak na tranziciju iz pre-dijabetesa u DM2. U ovoj studiji koristi ćemo dobro pozate mišje modele dijetom inducirane debljine (DIO), te odgovarajuće mišje mutante i druga oruđa kako bismo odgovorili na postaljena pitanja. Isto tako, usporediti ćemo eksperimentalne podatke sa podacima analize uzoraka sakupljenih od pretilih bolesnika što je također planirano projektom. Ovaj projekt povezuje imunologiju, virologiju i endokrinologiju. Istraživački tim ima dovoljno iskustva i znanja za uspješno provođenje predloženog istraživanja, te će bti sposoban stvoriti nova vrijedna i korisna saznanja o razvoju DM2-a i NASH-a. ]]></summary_hr><summary_en><![CDATA[Obesity is one of the most prominent and growing health problem of our time. It is estimated that more than a half billion of obese and another billion of overweight people live currently in the world. A significant number of them develop Diabetes Mellitus type 2 (DM2) and Non-alcoholic Fatty Liver Disease (NAFLD), which often coexist and share pathogenic abnormalities of obesity like insulin resistance (IR), dyslipidaemia and hypertension, which are features of the metabolic syndrome. Obesity is associated with a chronic systemic low-grade inflammation which is thought to be an important underlying cause of IR that leads to DM2 and NAFLD. Targeting of the underlying mechanisms of inflammation in both diseases therefore holds much promise for future therapies. However, the exact mechanisms that induce or aggravate inflammation and trigger transition from pre-diabetes to DM2 or from hepatic steatosis to non-alcoholic steatohepatitis (NASH) in obesity are still largely unclear. A better understanding of immunological causes of DM2 and NASH is therefore required.In this project we aim to investigate immune mechanisms that are important for induction of inflammatory processes in visceral adipose tissue (VAT) and liver, which are responsible for development of DM2 and NASH. In addition, our goal is to investigate viral factors that aggravate IR such as impact progression from pre-diabetes to DM2. In our study we will use well established mouse models of diet induced obesity (DIO) and appropriate mouse mutants and tools to address raised questions. We will compare experimental data with the analysis of samples collected from obese human subjects also planned in the project. Our project bridges immunology, virology and endocrinology. Our team has enough experience and expertise to drive successfully proposed research and will be able to provide valuable new insights in the development of DM2 and NASH. ]]></summary_en></project><project>
<id>7594</id><title_hr><![CDATA[Razumijevanje rimskih granica: primjer istočnog Jadrana]]></title_hr><title_en><![CDATA[Understanding Roman Borders: the Case of the Eastern Adriatic]]></title_en><user_id>7512</user_id><user_firstLast_name>Domagoj Tončinić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2018-01</proposal_call><code>IP-2018-01-4934</code><acronim><![CDATA[AdriaRom]]></acronim><duration>19.10.2018 - 18.10.2022</duration><status>Završio</status><financ_value>118.986,00 eur</financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Arheologija, </scie_field_hr><scie_field_en>Archeology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Filozofski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Humanities and Social Sciences]]></institution_en><team_members_id>7551, 7519, 7536, 7532, 7513, 7537, 7516, 19244, 23601, 25773, 4028, 17731, </team_members_id><team_members_names><![CDATA[Zrinka Šimić-Kanaet, Ina Miloglav, Zrinka Buljević, Sanja Ivčević, Iva Kaić, Ana Pavlović, Vinka Matijević, Miroslav Vuković, Joško Zaninović, Domagoj Bužanić, Mirjana Sanader, Mirna Vukov, ]]></team_members_names><keywords_hr><![CDATA[Istočni Jadran, Rimljani, pogranična zona, delmatski limes, rimski logori i kasteli, rimska vojska, nedestruktivne arheološke metode]]></keywords_hr><keywords_en><![CDATA[Eastern Adriatic, Romans, border zone, Delmataean limes, legionary fortresses, auxiliary forts, Roman army, non-destructive archaeology]]></keywords_en><summary_hr><![CDATA[Nakon uspjeha u Prvom punskom ratu, Rimljani su se zainteresirali za područje Grčke i Makedonije te su stoga počeli tražiti odgovarajuće prometne pravce prema tim teritorijima. Uz morski, jedini kopneni put vodio je duž istočne jadranske obale nastanjene narodima koje su Rimljani nazivali Ilirima. Rimsko osvajanje tog područja trajalo je od Prvog ilirskog rata 229. god. pr. Kr. do 9. god. po. Kr. Kako bi osigurali osvojeni teritorij između kolonija Jadera i Salone, gdje su se već smjestili prvi rimski imigranti, Rimljani su sagradili dva legijska logora i nekoliko kastela. U znanstvenoj literaturi taj je obrambeni sustav lakonski nazivan Delmatski limes, što je uzrokovalo trajnu znanstvenu raspravu. Međutim, zbog nedostatka arheoloških istraživanja koja bi podržala raspravu, još treba dovršiti sveobuhvatni pregled konteksta i značenja gore spomenute izgradnje. Namjera AdriaRom projekta jest istraživanje linije logora i kastela na tzv. Delmatskom limesu kako bi se pokazalo je li ta linija bila granica ili ne. Slijedom toga projekt bi pokušao pokazati koliku je ulogu ta granica imala u zaštiti rimskih imigranata i njihovih ekonomskih interesa. Pritom će projekt AdriaRom koristiti metodološki pristup temeljen na kombinaciji triju metoda: primjeni nedestruktivnih arheoloških istraživanja, ciljanih arheoloških iskopavanja i analizi arheoloških nalaza. Naime, ako su navedene građevne konstrukcije uistinu bile u funkciji obrane pogranične zone, to bi impliciralo da je tzv. Delmatski lime bio jedan od najranijih rimskodobnih obrambenih sustava.Ishodi predloženog projekta AdriaRom omogućit će bolje razumijevanje i potaknuti daljnje rasprave o razvoju rimskih granica, sigurnosnim i imigracijskim politikama u pograničnim zonama duž istočne obale Jadrana, kao i u rimskom svijetu općenito.]]></summary_hr><summary_en><![CDATA[Following their success in the First Punic War, the Romans became more interested in the area of Greece and Macedonia and hence sought appropriate routes to those territories. The only alternative to traveling there by the sea was using the overland route leading along the eastern Adriatic coast inhabited by the people referred to by Romans as Illyrians. The Roman conquest of this region lasted from the First Illyrian war in 229BCE until 9CE. To secure the conquered territory between the colonies of Iader and Salona, where the first Roman immigrants had already arrived, Romans built two fortresses and several forts. In the scientific literature, this defence construction was laconically called the Delmataean limes, and it has been the subject of persistent scientific discussion. However, due to insufficient archaeological research that would support the discussion, comprehensive overview of the context and meaning of above mentioned construction is yet to be completed.The aim of the AdriaRom project is to investigate the line of fortresses and forts of so called Delmataean limes in order to show whether that line was a border or not. Consequently, project aims to establish the role of the border in the protection of the safety and economic interests of Roman immigrants. In doing so, the AdriaRom project will use a methodological approach based on the combination of three methods: application of non-destructive archaeological research, targeted archaeological excavations and analysis of archaeological findings. Namely, if the stated construction was indeed intended to be a border line of a frontier zone, it would imply that so called Delmataean limes was one of the earliest Roman defence systems.The outcome of the proposed AdriaRom project will enable better understanding and drive further discussions about the development of Roman borders, security and immigration policies in frontier zones along the eastern Adriatic coast, as well as in the rest of the Roman world.]]></summary_en></project><project>
<id>7596</id><title_hr><![CDATA[Između istoka i zapada – dolina rijeke Cetine kao komunikacijska poveznica tijekom prapovijesti i antike]]></title_hr><title_en><![CDATA[]]></title_en><user_id>19187</user_id><user_firstLast_name>Helena Tomas Bakota</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-01</proposal_call><code>DOK-2018-01-5724</code><acronim><![CDATA[CeVaS]]></acronim><duration>01.09.2018 - 01.09.2022</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Arheologija, </scie_field_hr><scie_field_en>Archeology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Filozofski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Humanities and Social Sciences]]></institution_en><team_members_id>25379</team_members_id><team_members_names><![CDATA[ Doktorand: Jura Triplat ]]></team_members_names><keywords_hr><![CDATA[dolina rijeke Cetine, komunikacijski putevi, prapovijest, antika, naselja, grobnice, trgovačka razmjena, terenski pregled]]></keywords_hr><keywords_en><![CDATA[Cetina River Valley, communication pathway, prehistory, antiquity, settlement pattern, burials, trade and exchange, survey]]></keywords_en><summary_hr><![CDATA[U rano brončano doba u dolini Cetine razvila se cetinska kultura čije se odlike mogu naći po cijelom jadranskome bazenu, Malti i u Grčkoj. Stoga se s pravom može reći da je cetinska kultura predstavljala najznačajniju epohu prapovijesnoga života u dolini; ona ukazuje da su njeni nosioci mogli ostvariti kontakte s udaljenim krajevima. Rijeka Cetina, koja je u nekim svojim dijelovima plovna, pri tim je putovanjima vjerojatno služila kao važan put. Usprkos tako profitabilnoj komunikaciji koja je dolinu povezivala s Jadranom i vibrantnim Sredozemljem, razdoblja prije i nakon cetinske kulture nisu bila podjednako napredna. Jedan od ciljeva projekta jest ustanoviti koji su faktori utjecali na te varijacije kroz vrijeme. Također se namjeravaju utvrditi stupnjevi važnosti doline kao mjesta obitavališta i komunikacijskih puteva kroz prapovijesna i povijesna razdoblja. Ovi bi se ciljevi ostvarili metodom arheološkog rekognosciranja (terenskog pregleda) ciljano odabranih dijelova cetinske doline. Očekuje se da će otkriveni materijal ukazati na intenzitet naseljavanja doline u pojedinim razdobljima, ali i na intenzitet kontakata s ostalim, pogotovo udaljenijim područjima, pa će nam tako i odgovoriti na pitanja do koje je mjere u određenom razdoblju dolina bila izolirana ili pak otvorena vanjskome svijetu. Usporedbe s recentnijim epohama i događajima mogu ukazati na prednosti koje pruža život u tako plodnome okružju, ali isto tako i na nedostatke uvjetovane činjenicom da je cetinska dolina važna poveznica unutrašnjosti Balkanskoga poluotoka i Jadranskoga mora, pa je tako bila metom brojnih sila i poprištem čestih sukoba i ratova. Činjenica da je rimska legija nekoć bila stacionirana upravo u ovoj dolini (rimski vojni logor kod Trilja) govori nam da su slični problemi i sukobi život u dolini ugrožavali i u davnijoj prošlosti. Podaci prikupljeni predloženim rekognosciranjem zasigurno će pružiti bogatstvo novih arheoloških i povijesnih svjedočanstava o dolini Cetine.]]></summary_hr><summary_en><![CDATA[During the Early Bronze Age a culture developed in the Cetina Valley – the Cetina Culture – whose features over time got distributed in the Adriatic basin, Malta and Greece. That culture was a prehistoric highlight of the valley and demonstrated that its inhabitants were capable of establishing far-reaching contacts; the Cetina river, navigable at some parts, may have in that process served as a crucial communication channel. Despite this beneficial river giving access to the Adriatic sea and the vibrant Mediterranean basin, periods prior or posterior to the Cetina Culture were not equally prominent. The project seeks to explore the factors that may have influenced such a diachronic variation. Also, it aims to establish degrees of general importance of the valley as a place of habitation and communication through prehistoric and historic times. These goals will be achieved by archaeological surveying of the purposefully selected parts of the valley. The material recovered during surveying is expected to give an insight into the level of intensity of habitation of the area through time, as well as the intensity of foreign contacts (i.e. the isolation of the valley versus its receptiveness of the outside world). Comparisons to more recent periods or episodes may highlight the advantages of living in a very fertile environment, but also disadvantages caused by the role of the Cetina Valley as a transit zone from the inner Balkan peninsula to the open sea. As such, the valley has been a stage of numerous conflicts and wars. The fact that a Roman legion was once settled in the Valley (the fort of Tilurium) testifies that conflicts may have disturbed the life in the valley even in a more distant past. In brief, data obtained through a systematic archaeological survey will certainly reveal valuable archaeological and historical testimonies, but will also enhance the awareness of present local communities of the rich past of the valley.]]></summary_en></project><project>
<id>7598</id><title_hr><![CDATA[Kristalno inženjerstvo višekomponentnih metaloorganskih materijala povezanih halogenskom vezom: ususret supramolekulskom ugađanju strukture i svojstava]]></title_hr><title_en><![CDATA[]]></title_en><user_id>310</user_id><user_firstLast_name>Vladimir Stilinović</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-01</proposal_call><code>DOK-2018-01-7325</code><acronim><![CDATA[CrystEngMOM]]></acronim><duration>10.10.2018 - 09.10.2022</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, </scie_field_hr><scie_field_en>Chemistry, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>25323</team_members_id><team_members_names><![CDATA[ Doktorand: Luka Fotović ]]></team_members_names><keywords_hr><![CDATA[Halogenska veza, metaloorganski materijali, kokristali, supramolekulska kemija, mehanosinteza]]></keywords_hr><keywords_en><![CDATA[Halogen bond, metal-organic materials, cocrystals, supramolecular chemistry, mechanosynthesis]]></keywords_en><summary_hr><![CDATA[Glavni cilj predloženog istraživanja je razvijanje općeg principa priprave višekomponentnih kristalnih materijala (kokristala) ugodivih svojstava koji sadrže metaloorganske jedinice povezane halogenskim vezama. Ciljana sinteza kokristala metaloorganskih spojeva s donorima halogenske veze predstavljala bi značajan doprinos ne samo kristalnom inženjerstvu već i kemiji materijala te supramolekulskoj kemiji krutina. Predloženo istraživanje otvorit će put ka sintezi novih supramolekulskih krutina kontrolirane strukture i dimenzionalnosti sastavljenih od metaloorganskih jedinica. Takvi materijali mogu imati magnetska, optička i električna svojstva različita od svojstava organskih supramolekulskih materijala. Uz temeljne spoznaje o povezivanju metaloorganskih spojeva halogenskim vezama, proučit će se mogućnost primjene takovog povezivanja u ciljanoj sintezi fotoosjetljivih materijala, navlast kokristala sposobnih prevoditi svjetlostnu energiju u mehaničku. Drugi dio predloženog projekta bit će dizajn i sinteza organskih višekomponentnih materijala povezanih halogenskim vezama. Do sada je izučavanje halogenskih veza bilo osjetno ograničeno jednoličnošću dostupnih donora halogenske veze. Predložena istraživačka skupina spaja iskustva pojedinih suradnika u kovalentnoj sintezi, koordinacijskoj kemiji te kristalnim inženjerstvu, što će omogućiti sintezu kako novih donora halogenske veze, tako i metaloorganskih akceptora te supramolekulskih krutina. Ti će spojevi omogućiti temeljno istraživanje sintonâ halogenske veze, te izučavanje pouzdanih načina izrade proširenih metaloorganskih materijala povezanih halogenskim vezama i mogućnosti priprave izostrukturnih metaloorganskih kokristala radi ugađanja svojstava materijala unošenjem samo malih promjena u zadanu arhitekturu kokristala.]]></summary_hr><summary_en><![CDATA[The principal aim of the proposed research is to develop the first general designs for the assembly of functional multicomponent crystalline materials (cocrystals) involving metal-organic units organized by way of halogen-bonding interactions. The controlled and deliberate synthesis of halogen-bonded cocrystals involving metal-organic building blocks remains an outstanding challenge of crystal engineering, materials science and solid-state supramolecular chemistry. The proposed research will open a path to synthesize new molecular materials with controlled 1-, 2- or 3-D architectures, involving metal-organic building blocks which are expected to provide access to new magnetic, optical and electrical properties not usually available in carbon-based supramolecular networks. In particular, besides establishing the fundamental aspects of the design of halogen-bonded metal-organic materials, the proposed research will explore the application of these designs in the synthesis of photoresponsive switching materials, specifically of cocrystals capable of transforming light into mechanical motion. Another element of the proposed research project will be the design and synthesis of purely organic halogen-bonded multi-component materials. The field of halogen-bonded cocrystals has so far been heavily limited by the poor availability of diverse halogen bond donor building blocks. A particular strength of the assembled research team lies in the extensive experience in covalent synthesis, coordination chemistry and crystal engineering, enabling the synthesis of new halogen bond donors of different bonding strength and directionality, which will be employed for the fundamental studies of halogen bonding synthons, of reliable strategies for the construction of extended halogen bonded metal-organic materials, and of isostructural metal-organic cocrystals as a means to fine-tune the properties of solid materials by introducing minute differences into a given cocrystal architecture.]]></summary_en></project><project>
<id>7604</id><title_hr><![CDATA[Arhitekture eksaskalarnih računala visokih performanci]]></title_hr><title_en><![CDATA[High Performance Computing Architectures for Exascale Era]]></title_en><user_id>5886</user_id><user_firstLast_name>Mario Kovač</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2018-01</proposal_call><code>IP-2018-01-7674</code><acronim><![CDATA[HPCExa]]></acronim><duration>01.06.2019 - 31.05.2023</duration><status>Prekinut</status><financ_value>111.212,33 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Računarstvo, </scie_field_hr><scie_field_en>Computer sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Fakultet elektrotehnike i računarstva]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Electrical Engineering and Computing]]></institution_en><team_members_id>170, 24050, 3619, 5946, 6062, 5914, </team_members_id><team_members_names><![CDATA[Josip Knezović, Alen Duspara, Daniel Hofman, Igor Čavrak, Vlado Sruk, Hrvoje Mlinaric, ]]></team_members_names><keywords_hr><![CDATA[računarstvo visokih performanci, eksaskalarno računarstvo, heterogene arhitekture, energetski učinkovito računarstvo,  akceleratori, optimizacija]]></keywords_hr><keywords_en><![CDATA[High Performance Computing, exascale computing, heterogeneous architectures, energy efficient computing, accelerators, application optimisation]]></keywords_en><summary_hr><![CDATA[Globalni izazov eksaskalarnom računarstvu visokih performanci (engl. HPC) je izgraditi sustav koji će isporučiti 50 GFlops/W. Kako bi se riješio taj problem, uporaba HPC arhitektura temeljenih na akceleratorima dobila je značajnu ulogu u proteklim godinama. Potrebna nam je nova heterogena arhitektura koja se može učinkovito prilagoditi širokom rasponu aplikacija kako bi se premostio jaz snage i performansi uz održavanje primjenjivosti. Aplikacije obično imaju skup pareto-optimalnih izvedbi koje u obzir uzimaju mnoštvo kompromisa između mjerljivih podataka kao što su performance, propusnost, moć, energija, trošak, kvaliteta usluge, ograničenja vremena i sl.HPCExa projekt ima za cilj istražiti i predložiti eksaskalarnu heterogenu arhitekturu za buduće HPC sustave koji su temeljeni na novim arhitekturalnim značajkama, kao što su Intel x86 SIMD i vektorska proširenja, nove ISA inicijative (RISC-V) i već prisutne ARM-temeljene ISA-e, zajedno s akceleratorima za odabrane računalno-intenzivne aplikacije. Projekt će istražiti kombinacije akceleratora koje uključuju: RISC CPU male potrošnje, akceleratore temeljene na GPU-u i prilagodljive akceleratore. Kako bismo ostvarili predložene ciljeve usredotočit ćemo se na dva glavna računarska uzorka: a) iznimno visoka mogućnost paralelizacije podataka, veliki i dinamičan raspon (eng. floating point) računanja na velikim multidimenzionalnim redovima s podesivom preciznosti. Ovo će pokriti većinu aplikacija koje se koriste u HPC-u, uključujući i strojno učenje. b) operacije s cijelim brojevima, manipulacijom bitova, s visokom paralelizacijom na razini proizvođač - potrošač. Ovo pokriva aplikacije transkodiranja i kriptiranja. Cilj nam je razviti studije slučaja i demonstracije provjere valjanosti za aplikacije koje se izvode na predloženom sustavu: umjetna inteligencija, video transkodiranje i 3D/4D obrada medicinskih slika u realnom vremenu. Konačno, projekt će integrirati rezultate u EPI H2020 FPA projekt.]]></summary_hr><summary_en><![CDATA[A global exascale challenge in High Performance Computing (HPC) is to build a system that would deliver 50 GFlops/W. To address this problem, the use of accelerator based HPC has gained significant importance in the last years. We need a novel heterogeneous architecture that can be efficiently customized to a wide range of applications to bridge the power/performance gap while maintaining applicability. Applications generally have a set of Pareto-optimal implementations that trade-off numerous metrics such as performance, throughput, power, energy, cost, quality of service, timing constraints etc. The HPCExa project aims to explore and propose the Exascale Heterogeneous Architectures for next-generation HPC based on novel architectural features such as SIMD and Vector extensions, new ISA initiatives such as RISC-V and already present and consolidated ARM-based ISA, together with customized and customizable accelerators for selected compute-intensive applications.  The project will Investigate the accelerator mixes comprising of: low-power RISC CPUs, GPU-based accelerators and custom designed FPGA accelerators. To make the proposed accelerators goals attainable, we will focus on two main computational patterns: a) extremely data-parallel, high-dynamic range (floating point) computation on large multidimensional arrays with tunable precision. This will cover most of classical HPC applications as well as machine learning (AI).  b) integer/fixed-point, bit-manipulation centric computation, with extreme producer-consumer parallelism. This covers transcoding and crypto application. We then aim to develop the case studies and validation demonstrators for the following applications running on the proposed Heterogeneous Computing System: Artificial Intelligence (AI), Video Transcoding (VT), and 3D/4D Real-Time Medical Image Processing (MP). Finally, the project will integrate the results into EPI H2020 FPA project.]]></summary_en></project><project>
<id>7605</id><title_hr><![CDATA[Sinteza supramolekulskih samo-udruženih nanostruktura za izgradnju naprednih funkcionalnih materijala]]></title_hr><title_en><![CDATA[Synthesis of Supramolecular Self-assembled Nanostructures for Construction of Advanced Functional Materials]]></title_en><user_id>348</user_id><user_firstLast_name>Leo Frkanec</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2018-01</proposal_call><code>IP-2018-01-6910</code><acronim><![CDATA[SUPeRNANO]]></acronim><duration>06.11.2018 - 05.11.2022</duration><status>Završio</status><financ_value>132.722,81 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, </scie_field_hr><scie_field_en>Chemistry, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>21266, 963, 1104, 4852, 7690, 9862, 7725, 2927, 28075, 864887, 865253, </team_members_id><team_members_names><![CDATA[Tomislav Gregorić, Tomislav Portada, Ruža Frkanec, Adela Štimac, Vladislav Tomišić, Žiga  Jakopin , Mladen Žinić, Berislav Perić, Nika Gazdek, Ivona Čipor, Marcela Šišić, ]]></team_members_names><keywords_hr><![CDATA[supramolekulska kemija,  sinteza, samo-udruge, nanostrukture, napredni funkcionalni materijala]]></keywords_hr><keywords_en><![CDATA[Supramolecular Chemistry, Synthesis, Self-assembles, Nanostructures, Advanced Functional Materials]]></keywords_en><summary_hr><![CDATA[Istraživanja u okviru predloženog projekta su interdisciplinarna s ciljem dizajna, supramolekulske  sinteze i karakterizacije novih samoorganizirajućih nano-struktura za izgradnju naprednih funkcionalnih materijala. Molekularno samoudruživanje koristi prednosti supramolekulskih interakcija (ionske, hidrofobne, van der Waals-ove, vodikove i koordinacijske veze)  koje omogućavaju konstruiranje novih nanostruktura  atraktivnih svojstava. Temeljeno na zakonitostima supramolekulske kemije, „bottom-up“ pristup za projektiranje funkcionalnih struktura u nano dimenzijama omogućuje nastajanje vrlo sofisticiranih materijala za široku primjenu. Takve strukturne karakteristike danas su dobro poznate i mogu se precizno kontrolirati kako bi se uvela i prilagodila specifična funkcionalna svojstva samoorganiziranih nanomaterijala. Nadalje, ovi sustavi pokazuju složenu morfologiju i dinamiku te imaju veliki potencijal za primjenu u biomedicinskim znanostima, informacijskim tehnologijama i znanostima o okolišu. U nastavku naših istraživanja supramolekulskih sustava pažnja u ovom projektu bit će usmjerena na dva glavna područja: 1) nanoproizvode, sintezu i karakterizacija novih mekih nanomaterijala temeljenih na organo- i hidro-gelovima s inkorporiranim oksalilamidnim ili fumaramidnim centralnim jedinicama i sinteze bioinspiriranih supramolekulskih sustava baziranih na samoorganizacijama  prirodnih peptida, priprava novih materijala polimerizacijom gelske mreže i razvoj novih supramolekulskih materijala koje uključuju fotoaktivne funkcionalne skupine 2) dizajn, priprema i karakterizacija novih funkcionalnih supramolekulskih sustava baziranih na liposomima i ß-ciklodekstrinama za ciljanu dostavu lijekova i istraživanje staničnog prepoznavanja. Nadalje, testirat će se biološki potencijal sintetiziranih funkcionalnih supramolekulskih sustava u dostavi lijekova i genskoj dostavi.]]></summary_hr><summary_en><![CDATA[Research in the framework of the proposed project is interdisciplinary with the aim of design, supramolecular synthesis and characterization of new functional supramolecular self-assembled nanostructures for construction of advanced functional materials. Molecular self-assembly usually takes advantage of supramolecular interactions (ionic, hydrophobic, van der Waals, hydrogen and coordination bonds) which allow construction of new nanostructures with attractive properties. Based on the rules of supramolecular chemistry, the bottom-up approach to design functional structures at the nanoscale is currently producing highly sophisticated materials for wide application. These structural features are nowadays well understood and can be finely controlled in order to introduce and tune specific functional properties of self-assembled nanomaterials. Further, such systems exhibit a complex array of morphologies and dynamics and have a huge potential for new applications in biomedical sciences, information technologies and environmental sciences. In continuation of our previous research of self-assembly systems the attention in this project will be focused on two main areas of research: 1) nanofabrication, preparation and characterization of new soft nanomaterials based on organo- and hydro-gels with incorporated oxalylamide or fumaramide central units and synthesis of bioinspirated supramolecular systems based on self-assembled natural peptides, the preparation of new materials by gel polymerization and the development of new supramolecular materials that incorporate photoactive functional groups 2) design, preparation and characterization of new functional supramolecular systems based on liposomes and ß-cyclodextrines for targeted drug delivery and surface recognition studies. Further, biological potential of synthesized functional supramolecular systems in drug and gene delivery will be tested. ]]></summary_en></project><project>
<id>7608</id><title_hr><![CDATA[Razvoj kapilarne mikroprobe za MeV SIMS s primjenom na analizu bioloških materijala]]></title_hr><title_en><![CDATA[]]></title_en><user_id>2755</user_id><user_firstLast_name>Ivančica Bogdanović Radović</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-01</proposal_call><code>DOK-2018-01-4454</code><acronim><![CDATA[BioCapSIMS]]></acronim><duration>09.10.2018 - 08.10.2022</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, </scie_field_hr><scie_field_en>Physics, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>25285</team_members_id><team_members_names><![CDATA[ Doktorand: Marko Brajković ]]></team_members_names><keywords_hr><![CDATA[teški ioni, kapilarna mikroproba, MeV SIMS, biološki uzorci, ispodmikronska rezolucija]]></keywords_hr><keywords_en><![CDATA[heavy ions, capillary microbeam, MeV SIMS, biological samples, sub-micron resolution]]></keywords_en><summary_hr><![CDATA[Određivanje molekularnog sastava na staničnom nivou važno je za razumjevanje biokemijskih procesa unutar stanica a time i za istraživanje nastanka pojedinih bolesti. Jedna od obećavajućih masenih spektrometrija za 2D molekularno mapiranje na staničnom nivou je i MeV SIMS, spektrometrija sekundarnih molekularnih iona pomoću iona MeVskih energija koja je 2013. instalirana na ionskoj mikroprobi akceleratora u Zagrebu. Nedavno je pokazano da je s trenutnim eksperimentalnim postavom moguće postići 2D mapiranje molekula unutar stanice s lateralnom razlučljivošću ispod jednog mikrometra. Ipak, puni potencijal metode moglo bi se ostvariti samo korištenjem najtežih iona (npr I, Au) energija oko 30 MeV-a, što u postojećem MeV SIMS sustavu na ionskoj mikroprobi IRB-a nije moguće zbog ograničenja u potrebnim magnetskim poljima ionsko-optičkih elemenata. Naime od ranije je poznato da prinos sekundarnih molekularnih iona jako ovisi o elektronskoj zaustavnoj moći iona koji se koriste kao pobuda, te je znatno veći ako se koriste teški ioni visokih energija. Visoka vjerojatnost ovih procesa omogućila bi da se umjesto složenog sustava fokusirajućih leća ionski snop kolimira na mikronske dimenzije pomoću staklene kapilare. Nova kapilarna mikroproba za MeV SIMS koja bi u potpunosti bila optimizirana za 2D mapiranje bioloških materijala bi zbog svoje jednostavnosti mogla biti u daleko široj primjeni posebno na akceleratorima koji nemaju složene i skupe sustave za fokusiranje iona. Također, kapilarna mikroproba sa masenim spektrometrom bit će izgrađena na centralnoj eksperimentalnoj liniji 6.0 MV tandem akceleratora IRB-a te bi se tako minimizirale i teškoće zakretanja ionskog snopa u skretnom magnetu. Na taj način dobio bi se uređaj koji bi i po lateralnoj razlučljivosti i po prinosu sekundarnih molekularnih iona bio superioran u odnosu na postojeće slične uređaje za masenu spektrometriju bioloških materijala.]]></summary_hr><summary_en><![CDATA[Determination of the molecular composition at the cellular level is important to understand the biochemical processes within the cells and thus to explore the occurrence of certain diseases. One of the promising mass spectrometry methods for 2D molecular mapping at the cellular level is MeV SIMS, spectrometry of secondary molecular ions using MeV ions that was installed in 2013 at the ion microprobe in Zagreb. Recently we have demonstrated that with the current experimental setup we can achieve 2D imaging of molecular distribution within the cell with the sub-micron later resolution. However, the full potential of the method could only be achieved by using heavier ions such as I or Au with energies up to 30 MeV, which is presently not possible in the current MeV SIMS setup due to the limitations in the required magnetic fields in the ion-optical elements. It is already known that the secondary molecular ion yield strongly depends on the electronic stopping power of the used ions which increases significantly for heavier high energy ions. High probability of these processes allow us that instead of a complex system of focusing lenses ion beam can be collimated to micron dimensions by using glass capillaries. New capillary microprobe for MeV SIMS that would be fully optimised for 2D mapping of biological samples due to its simplicity could be very interesting at accelerators facilities that do not have complex and expensive systems for ion focusing. Also, capillary microprobe mass spectrometer will be mounted in the central experimental line of the 6.0 MV tandem accelerator RBI in order to minimise the difficulties of turning ion beam to the other beam lines. In this way the setup can be obtained with the lateral resolution and secondary ion molecular yields that is superior to the existing similar setups for mass spectrometry of biological materials.]]></summary_en></project><project>
<id>7609</id><title_hr><![CDATA[Sto dvadeset i pet  milijuna piksela za otkriće vezanja Higgsovog bozona na fermione i novih čestica na Velikom hadronskom sudarivaču]]></title_hr><title_en><![CDATA[]]></title_en><user_id>19738</user_id><user_firstLast_name>Dinko Ferenček</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-01</proposal_call><code>DOK-2018-01-9182</code><acronim><![CDATA[HIGGS125]]></acronim><duration>14.06.2019 - 31.03.2023</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, </scie_field_hr><scie_field_en>Physics, </scie_field_en><institution_hr><![CDATA[Institut "Ruđer Bošković"]]></institution_hr><institution_en><![CDATA[Ruđer Bošković Institute in Zagreb]]></institution_en><team_members_id>29408</team_members_id><team_members_names><![CDATA[ Doktorand: Saswat Mishra ]]></team_members_names><keywords_hr><![CDATA[Higgsov bozon, fermionska vezanja, Standardni model, nove čestice, identifikacija b kvarkova, piksel detektor, LHC]]></keywords_hr><keywords_en><![CDATA[Higgs boson, fermionic couplings, Standard model, new particles,  b tagging, pixel detector, LHC]]></keywords_en><summary_hr><![CDATA[Ulaskom u drugu fazu rada Velikog hadronskog sudarivača čestica (LHC) na CERN-u započelo je još jedno uzbudljivo razdoblje u istraživanju temeljnih gradivnih  elemenata tvari. Opažanjem čestice sa svojstvima Higgsovog bozona na LHC-u čini se da je potvrđeno jedno od središnjih predviđanja Standardnog modela (SM) fizike čestica.  Međutim, sva svojstva otkrivene čestice tek se trebaju precizno odrediti kako bi se potvrdilo da je ona uistinu Higgsov bozon predviđen Standardnim modelom.  Cilj projekta je proučavanje vezanja Higgsovog bozona s fermionima, koja su u SM-u odgovorna za mase kvarkova i leptona. Ova vezanja dopuštaju raspade  Higgsovog bozona u fermione.  Međutim, takvi raspadi još nisu opaženi. Cilj projekta je opažanje raspada Higgsovog bozona u par b kvarkova  te precizno mjerenje učestalosti ovog raspada koristeći sve podatke koji će se prikupiti detektorom CMS u drugoj fazi rada LHC-a. Neopažanje ovog raspada ili odstupanje učestalosti raspada od vrijednosti predviđenih SM-om ukazalo bi na postojanje fizike izvan SM-a što bi bilo od iznimne važnosti. Cilj projekta su i izravne potrage za novim česticama proučavanjem konačnih stanja s b kvarkovima.  Projekt također namjerava pridonijeti poboljšanju performansi detektora CMS boljom identifikacijom hadronskih mlazova koji nastaju hadronizacijom b kvarkova (b mlazovi). Unapređenju identifikacije b mlazova (B označavanje) ponajviše će doprinijeti instalacija nadograđenog silicijskog piksel detektora početkom 2017. Jedan od ciljeva projekta je optimizacija performansi identifikacije b mlazova koristeći svojstva nadograđenog detektora, s posebnim naglaskom na označavanje topologija u kojima su se dva vrlo energijska b mlaza spojila u jedan mlaz. To će ovisiti o dobroj integraciji nadograđenog piksel detektora u CMS mjerenja, te projekt također uključuje niz ciljeva vezanih uz poboljšanje performansi piksel detektora i rekonstrukcije događaja.]]></summary_hr><summary_en><![CDATA[With the start of the second running phase (Run 2) of the Large Hadron Collider (LHC) at CERN, the study of the fundamental constituents of matter has again entered an exciting time. The observation of a Higgs-like boson at the LHC seems to confirm a central prediction of the Standard Model (SM) of particle physics. All properties of the discovered particle need however to be accurately determined to establish whether the new particle is the Higgs boson predicted in the SM.The proposal aims at studying the couplings of the Higgs boson to fermions, which in the SM gives rise to masses of quarks and leptons. These couplings allow the Higgs boson to decay into fermions. No such decay has however been observed yet. This projects targets an observation of the Higgs boson decay into a pair of b quarks, and a precise measurement of this decay rate using the full dataset to be acquired by the CMS detector during Run 2. A lack of observation of this decay or a deviation of its rate from the SM expectation would point at the presence of physics beyond the SM and be of great significance. The project also aims at direct searches for new particles by studying final states with b quarks.The project also intends to contribute to the improved performance of the CMS detector by improving the identification of hadronic jets stemming from the hadronization of a b quark (b-jets). The identification of b-jets (B tagging) will in particular benefit from the installation of an upgraded silicon pixel detector in early 2017. One of the project goals consists in optimizing the B tagging performance using the features of the upgraded detector, with a special focus on the tagging of topologies in which two very energetic b-jets are merged in one so-called “fat jet”. This relies on a good integration of the upgraded pixel detector in the CMS measurements, and the project therefore also includes a set of objectives linked to the improvement of the pixel detector performance and reconstruction.]]></summary_en></project><project>
<id>7610</id><title_hr><![CDATA[Interakcije slatkovodnih patogenih oomiceta i okoliša]]></title_hr><title_en><![CDATA[]]></title_en><user_id>18946</user_id><user_firstLast_name>Ana Bielen</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-01</proposal_call><code>DOK-2018-01-8751</code><acronim><![CDATA[InteractOomyc]]></acronim><duration>01.10.2018 - 30.09.2022</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Biotehnologija, </scie_field_hr><scie_field_en>Biotechnology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prehrambeno-biotehnološki fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Food Technology and Biotechnology]]></institution_en><team_members_id>25270</team_members_id><team_members_names><![CDATA[ Doktorand: Anđela Miljanović ]]></team_members_names><keywords_hr><![CDATA[patogeni oomiceti, slatkovodni rakovi, slatkovodna akvakultura, mikrobne zajednice, ekološke interakcije]]></keywords_hr><keywords_en><![CDATA[pathogenic oomycetes, freshwater crayfish, freshwater aquaculture, microbial communities, ecological interactions]]></keywords_en><summary_hr><![CDATA[U posljednja dva desetljeća globalno širenje oomicetnih patogena u slatkovodnim ekosustavima uzrokuje smanjenje brojnosti mnogih populacija. Istovremeno, oomicetni patogeni uzrokuju značajne ekonomske gubitke u slatkovodnoj akvakulturi. Unatoč tome, većina postojećih istraživanja fokusirana je na odnos domaćina i uzročnika bolesti, dok se drugi tipovi ekoloških interakcija u koje su uključeni slatkovodni oomiceti uglavnom ne uzimaju u obzir. Stoga je osnovni cilj predloženog projekta poboljšati razumijevanje ekologije oomicetnih patogena u slatkovodnim ekosustavima. Kao modelni organizmi koristiti će se dva patogena oomiceta - Aphanomyces astaci i Saprolegnia sp. A. astaci je kao uzročnik račje kuge odgovoran za nestanak brojnih populacija zavičajnih deseteronožnih rakova u Europi i time je goruća tema u području konzervacije rakova. Oomiceti iz roda Saprolegnia uzročnici su saprolegnioze - bolesti pastrve i drugih salmonidnih riba značajnih za slatkovodnu akvakulturu u Hrvatskoj i svijetu. Primjenom interdisciplinarnog pristupa u kojem će se preklopiti moderne kemijske, molekularno-biološke, mikrobiološke i bioinformatičke metode, projekt će odgovoriti na nekoliko međunarodno relevantnih i do sada neistraženih pitanja. Istražit će se utjecaj abiotskih (sastav vode) i biotskih (sastav mikrobnih zajednica) čimbenika na različite faze životnog ciklusa oomiceta. Na taj će se način predvidjeti &#39;&#39;vruće točke&#39;&#39; koje imaju povećani rizik od širenja/izbijanja bolesti uzrokovanih oomicetima u slatkovodnim ekosustavima. Osim toga, istražiti će se potencijal komenzalnih bakterijskih zajednica domaćina za inhibiciju rasta oomiceta, kao i odabranih biljnih ekstrakata koji bi se mogli primijeniti kao mjera kontrole saprolegnioze u akvakulturi. Zaključno, rezultati predloženog projekta donijet će nova fundamentalna znanja o interakcijama oomicetnih patogena i njihovog okoliša te istražiti nove metode njihove kontrole.]]></summary_hr><summary_en><![CDATA[In the last two decades, global spreading of oomycete pathogens in freshwater ecosystems is causing decline of many populations. At the same time, oomycete pathogens are also causing significant economic losses in freshwater aquaculture. Despite of this, most of the existing research is focused on host/pathogen relationship, whereas other types of ecological interactions are largely overlooked. Therefore, the main objective of the proposed project is to improve understanding of the oomycete pathogens ecology in freshwater ecosystems. Two model oomycete pathogens will be used - Aphanomyces astaci and Saprolegnia sp. A. astaci is the causative agent of crayfish plague and is responsible for the disappearance of numerous indigenous decapod crayfish populations in Europe, which makes it a hot topic in the area of crayfish conservation. Oomycetes in the genus Saprolegnia are causing saprolegniosis – a disease of trouts and other salmonid fish important for freshwater aquaculture in Croatia and globally. Using an interdisciplinary approach with complementing methods in chemistry, molecular biology, microbiology and bioinformatics, the project will try to answer on several so far unexplored and internationaly relevant issues. The effect of abiotic (water composition) and biotic (microbial communities composition) factors on different oomycetal life cycle stages will be investigated. In that manner „hot spots“ in freshwater ecosystem will be predicted, having increased risk for outbreak/spreading of diseases caused by oomycete pathogens. In addition, the potential of hosts comensal bacterial communities and selected plant extracts to inhibit the growth of oomycetes will be investigated, as well as their potential application in controlling saprolegniosis in aquaculture. In summary, results of the proposed project will bring about new basic knowledge about oomycete pathogens interaction with their environment, and asses new methods for their control. ]]></summary_en></project><project>
<id>7612</id><title_hr><![CDATA[Međuusporedba metoda mjerenja denudacije krša]]></title_hr><title_en><![CDATA[Inter-comparison of karst denudation measurement methods]]></title_en><user_id>6006</user_id><user_firstLast_name>Kristina Krklec</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2018-01</proposal_call><code>IP-2018-01-7080</code><acronim><![CDATA[KADEME]]></acronim><duration>01.10.2018 - 30.09.2022</duration><status>Završio</status><financ_value>132.632,56 eur</financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Poljoprivreda, </scie_field_hr><scie_field_en>Agriculture, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Agronomski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Agriculture]]></institution_en><team_members_id>4675, 19493, 20456, 24181, 24134, 24096, 24218, 25734, 855332, 865056, </team_members_id><team_members_names><![CDATA[Sonja Lojen, David Domínguez-Villar, Aleksandra Bensa, Braucher Regis, Sanja Lozić, Dražen Perica, Natalija Andačić, Kristina Koret, Mirna Švob, Josip Šušnjar, ]]></team_members_names><keywords_hr><![CDATA[denudacija, trošenje stijena, tlo, krš, špilja]]></keywords_hr><keywords_en><![CDATA[denudation, rock weathering, soil, karst, cave]]></keywords_en><summary_hr><![CDATA[Denudacija površine temeljni je proces razvoja reljefa i tla. Otapanjem karbonata ostaje netopivi ostatak iz kojeg se može razviti tlo. Stoga je poznavanje brzine trošenja stijena i denudacije važno za evaluaciju potrebnog vremena za razvoj tla. Postoji nekoliko različitih metodoloških pristupa za mjerenje stope denudacije. Najčešće se koriste: izlaganje stijenskih pločica uvjetima u okolišu; upotreba mikro-erozijskog metra; mjerenje koncentracije kozmogenih radionuklida na izloženim stijenama i mjerenje hidrokemijskih značajki vode u svrhu određivanja količine otopljenih karbonatnih stijena. Svaka metoda ima prednosti i nedostatke i ne postoji konsenzus o tome koja metoda pruža najpouzdanije vrijednosti stope denudacije, štoviše, zabilježene su značajne razlike u rezultatima među metodama. Stoga ovo istraživanje ima za cilj identificirati metode koje bi mogle pružiti pristrane rezultate i ukazati na prednosti i nedostatke svake metode, kako bi se istraživačima olakšao odabir bolje metode ovisno o ciljevima njihovih istraživanja.Metode će se primijeniti na dvije različite lokacije pod utjecajem mediteranske klime, ali s vrlo različitom debljinom tla. Ovaj pristup važan je za vrednovanje sprege stope denudacije i debljine tla, te za utvrđivanje jesu li rezultati usporedbe metoda sustavni na mjestima s promjenjivom značajkama. Dobivene stope denudacije koristiti će se za procjenu produkcije materijala na lokacijama istraživanja, odnosno za proučavanje potencijalne proizvodnje tla ovisno o denudaciji. Važnost ovoga ogleda se u činjenici da je u scenariju erozije tla u mediteranskoj regiji važno znati potencijal oporavka tih sustava.]]></summary_hr><summary_en><![CDATA[Denudation of earth surface is the fundamental process governing the landscape and soil development. The dissolution of carbonates results in insoluble material of these rocks being available for the development of soils. Therefore, knowing rock denudation-weathering rates is important to evaluate the time required for a certain soil to develop. There are several different methodological approaches to measure denudation rate. The must commonly used are: the exposure of rock tablets to the natural environment; the use of micro-erosion meters; measuring the concentration of cosmogenic radionuclides on exposed rocks and measuring water hydrochemistry to infer amount of carbonates being dissolved. Every method has pros and cons and there is no consensus on which method provides the more reliable denudation rates, furthermore, significant differences among methods have been reported. Therefore, this investigation aims to identify methods that could provide biased results and as well to report the strengths and flaws of every method, to help researchers to select the better methods depending on the goals of their particular studies.The methods will be applied at two different locations affected by Mediterranean climate, but with very different soil thickness. This approach is important to evaluate the feedback of soil thickness on denudation rates, and confirm if the conclusions from the method comparison are systematic on sites with variable characteristics. The denudation rates obtained will be used to evaluate the production of material at the studied sites to study the potential production of soil depending on denudation. This is important, since in a scenario of soil erosion in the Mediterranean region, it is important to know the potential recovery of these systems. ]]></summary_en></project><project>
<id>7613</id><title_hr><![CDATA[Utjecaj prehrambenih vlakana na bioraspoloživost polifenola istraživanjem adsorpcije i simuliranih probavnih procesa, in vitro]]></title_hr><title_en><![CDATA[]]></title_en><user_id>7376</user_id><user_firstLast_name>Lidija Jakobek Barron</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-01</proposal_call><code>DOK-2018-01-6710</code><acronim><![CDATA[BIO-POLIFENOL]]></acronim><duration>01.10.2018 - 30.09.2022</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Biotehničke znanosti</scie_area_hr><scie_area_en>Biotechnical sciences</scie_area_en><scie_field_hr>Prehrambena tehnologija, </scie_field_hr><scie_field_en>Food technology, </scie_field_en><institution_hr><![CDATA[Sveučilište Josipa Jurja Strossmayera u Osijeku, Prehrambeno-tehnološki fakultet]]></institution_hr><institution_en><![CDATA[Josip Juraj Strossmayer University of Osijek, Faculty of Food Technology]]></institution_en><team_members_id>25258</team_members_id><team_members_names><![CDATA[ Doktorand: Jozo Ištuk ]]></team_members_names><keywords_hr><![CDATA[adsorpcija, bioraspoloživost, b-glukan, prehrambena vlakna, polifenoli, bioaktivnosti]]></keywords_hr><keywords_en><![CDATA[adsorption, bioaccessibility, b-glucan, dietary fiber, polyphenols, bioactivities]]></keywords_en><summary_hr><![CDATA[Ranijim istraživanjima pokazalo se da polifenolni spojevi imaju razne bioaktivnosti. Od antioksidacijskog djelovanja do modulacije enzima, djelovanja metabolita polifenola, interakcija s mikroflorom te interakcija s makromolekulama prisutnima u hrani. Sve ove bioaktivnosti mogu zajedno objasniti potencijalno pozitivan utjecaj polifenola na zdravlje. U zadnje vrijeme pažnja se posvećuje interakcijama s makromolekulama u hrani jer one mogu utjecati na bioraspoloživost polifenola. Bioraspoloživost se definira kao količina nutrijenata koji su raspoloživi za apsorpciju u probavnom traktu. Ukoliko polifenoli kroz interakcije s molekulama iz hrane bivaju “zarobljeni” (vezani) za molekule to može utjecati na raspoloživost za njihovu apsorpciju te na njihovo djelovanje u organizmu. Prehrambena vlakna imaju potencijal  vezanja polifenola te ih na taj način mogu zaštititi od razgradnje i prenijeti u donje dijelove probavnog trakta. To može utjecati na bioraspoloživost, ali imati i druge potencijalno pozitivne efekte – polifenoli mogu u izvornom obliku pokazati pozitivne bioaktivnosti u donjim dijelovima probavnog trakta. U ovom projektu cilj je istražiti bioraspoloživost polifenola kroz dva procesa. Prvi bi bio istraživanje procesa adsorpcije polifenola na prehrambenim vlaknima (b-glukan). U ovom dijelu istraživala bi se adsorpcija polifenolnih standarda na prehrambena vlakna (b-glukan) te utjecaj pH, temperature i vremena na adsorpciju. Preko adsorpcije bi se interpretirale interakcije koje se mogu dogoditi između polifenola i prehrambenih vlakana. Drugi proces koji bi se istraživao bio bi simulirani probavni proces, in vitro, u kojem bi se simulirali probavni procesi te istraživala količina polifenola (iz voća) u izvornom obliku nakon probave te utjecaj prehrambenih vlakana na ovaj proces. Rezultatima iz istraživanja adsorpcije i simuliranih probavnih procesa interpretirala bi se bioraspoloživost polifenola te utjecaj prehrambenih vlakana na bioraspoloživost.]]></summary_hr><summary_en><![CDATA[Previous studies have shown that the polyphenolic compounds have various bioactivities: from antioxidant activity to the modulation of enzymes, the action of polyphenol metabolites, interaction with the microflora, and interactions with macromolecules present in food. All of these bioactivities can together explain a potentially positive effect of polyphenols on health. Lately, attention is paid to interactions with macromolecules in food because they can affect the bioaccessibility of polyphenols. Bioaccessibility is defined as the amount of nutrients available for absorption in the gastrointestinal tract. If polyphenols through interaction with molecules from food are &#39;&#39;captured&#39;&#39; (linked) to molecules that can affect the availability for their absorption and their effects in the body. Dietary fibers have the potential to bind polyphenols. Polyphenols can thus be protected from degradation and transferred to the lower parts of intestinal tract. This may affect the bioaccessibility, or have other potentially positive effects - polyphenols may in their original form show positive bioactivities in the lower digestive tract. In this project, the goal is to explore the bioaccessibility of polyphenols through two processes. The first will be the study the adsorption of polyphenols onto dietary fiber (b-glucan), along with the impact of pH, temperature and time on this process. Through adsorption, the interactions that can occur between polyphenols and dietary fiber could be interpreted. Another process that will be studied is the simulated digestion process, in vitro, which would simulate the digestive processes, explore the amount of polyphenols (in fruit) in its original form upon digestion, and the effect of dietary fiber on this process. The results from the adsorption and simulated digestive processes would be used to interpret bioaccessibility of polyphenols and the impact of dietary fiber on bioaccessibility.]]></summary_en></project><project>
<id>7614</id><title_hr><![CDATA[MATH-BTB proteini kao regulatori transkripcije i RNA posredovane metilacije DNA u biljnom razvitku]]></title_hr><title_en><![CDATA[]]></title_en><user_id>3746</user_id><user_firstLast_name>Dunja Leljak-Levanić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-01</proposal_call><code>DOK-2018-01-2144</code><acronim><![CDATA[PHYTOMETHDEV]]></acronim><duration>10.10.2018 - 31.12.2022</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Biologija, </scie_field_hr><scie_field_en>Biology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>25338</team_members_id><team_members_names><![CDATA[ Doktorand: Tamara Vuk ]]></team_members_names><keywords_hr><![CDATA[metilacija DNA, RdDM, MATH-BTB, embriogeneza, stres, biljke]]></keywords_hr><keywords_en><![CDATA[DNA methylation, RdDM, MATH-BTB, embryogenesis, stress, plants]]></keywords_en><summary_hr><![CDATA[Metilacija DNA jedan je od nekoliko epigenetičkih mehanizama kontrole ekspresije gena. U biljaka raznolikost epigenetičkih mehanizama ima, osim u regulaciji razvojnih procesa, važnu ulogu u fenotipskoj i fiziološkoj prilagodljivosti, te sposobnosti biljaka da prežive i razmnožavaju se u promjenjivom okolišu. Metilacija biljne DNA odvija se na sljedovima CG, CHG i asimetričnom CHH (H simbol za A, C ili T), a svaki od njih ima različite &#39;&#39;genetičke zahtjeve&#39;&#39; za očuvanje. Nesimetrična metilacija CHH ne može se održati i zahtijeva de novo metilaciju u svakom staničnom ciklusu. Proces kojim se to ostvaruje je metilacija DNA usmjerena s RNA (RdDM). Dvije RNA polimeraze specifične za biljke, Pol IV i Pol V sintetiziraju male interferirajuće RNA, odnosno dugačke nekodirajuće molekule RNA, važne za RNA-DNA prepoznavanje. Kompleks DDR predstavlja proteinski kompleks za koji se smatra da je odgovoran za dovođenje enzima Pol V na mjesto regulacije gena, no mehanizam specifičnosti nije jasan. Naši preliminarni rezultati ukazuju da proteini MATH-BTB iz uročnjaka stupaju u interakciju s kompleksom DDR, te tako mogu posredovati u pozicioniranju sustava RdDM. Najnovija otkrića ukazuju da su supstrati proteina BPM transkripcijski faktori. Proteini s ovakvim interakcijskim mogućnostima imaju potencijal  održavanja ravnoteže između metilacije (posredovane Pol V) i transkripcije (posredovane Pol II). Glavni cilj projekta je rasvjetljavanje funkcionalne uloge proteina BPM u regulaciji transkripcije i RdDM-a kao i moguće uloge u biljnoj embriogenezi i prilagodbi na stresne uvjete. Posebna pozornost biti će dana identifikaciji gena čija je transkripcija ili RdDM metilacija uravnotežena proteinom BPM1 (kromatinska imunoprecipitacija-ChIP, ChIP-sekvenciranje). Nadalje, metilacijski uzorak (bisulfitno sekvenciranje) odabranih gena će biti povezan s njihovom ekspresijom (Q-PCR), te s embriogenezom i odgovorom biljaka na stres u linijama s promijenjenim sustavom RdDM ili ekspresijom gena BPM.]]></summary_hr><summary_en><![CDATA[DNA methylation is one of several epigenetic mechanisms used by cells to control gene expression. In plants epigenetic diversity, besides regulating development, presumably contributes in plant phenotypic and physiological plasticity and the ability to survive and reproduce in unpredictable environments. Plant DNA methylation occurs at CG, CHG and nonsymmetrical CHH (where H is A, C or T) sequences, each of which has different genetic requirements for its preservation. Nonsymmetrical CHH methylation cannot be sustained by the maintenance machinery and require de novo methylation in each cell cycle through a process called RNA-directed DNA methylation (RdDM). Two plant specific RNA polymerases, Pol IV and Pol V, produce small interfering RNAs and long non-coding RNAs respectively, which are important for RNA-DNA target sequence recognition. The DDR complex represents a major determinant that is proposed to be responsible for recruitment of the Pol V enzyme to the specific loci, but the mechanism is still not clear. Our preliminary results indicate that Arabidopsis MATH-BTB proteins recognize and interact with the DDR complex and thus might mediate the positioning of RdDM machinery. Recent findings indicate that substrates of BPM proteins are predominantly transcription factors. These two properties of a single BPM protein suggest its capacity to act as a control switch between methylation (mediated by Pol V) and transcription (mediated by Pol II). The main goal of this project is to elucidate the functional roles of BPMs in orchestrating transcription and RdDM, and its possible role in plant embryogenesis and stress adaptation. Particular focus will be placed to identification of genes whose transcription or RdDM methylation is affected by BPMs (by ChIP and ChIP seq). Further, methylation context (bisulfite sequencing) of selected genes will be correlated with their expression (Q-PCR) and with embryogeneis and stress responses in different RdDM and BPM mutant lines.]]></summary_en></project><project>
<id>7615</id><title_hr><![CDATA[Demistificiranje dvočestičnih korelacija u pp sudarima s nadograđenom komorom vremenske projekcije]]></title_hr><title_en><![CDATA[Demystifying Two Particle Correlations in pp collisions with the upgraded Time Projection Chamber]]></title_en><user_id>7691</user_id><user_firstLast_name>Mirko Planinić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2018-01</proposal_call><code>IP-2018-01-4108</code><acronim><![CDATA[TPCwithTPC]]></acronim><duration>01.10.2018 - 31.10.2022</duration><status>Završio</status><financ_value>132.515,36 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Fizika, </scie_field_hr><scie_field_en>Physics, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>12808, 13010, 24010, 13058, 28908, </team_members_id><team_members_names><![CDATA[Nikola Poljak, Filip Erhardt, Marko Jerčić, Antonija Utrobičić, David Karatović , ]]></team_members_names><keywords_hr><![CDATA[Dvočestične korelacije, Kvarkovsko-gluonska plazma, TPC, GEM, Iskrenje, RIDGE]]></keywords_hr><keywords_en><![CDATA[Two particle correlations, Quark-Gluon Plasma (QGP), TPC, GEM, sparking, RIDGE]]></keywords_en><summary_hr><![CDATA[Primarni cilj ovog projekta je istražiti dvočestične korelacije čestica u sudarima protona (pp) koristeći varijable oblika događaja koje je naša grupa u prethodnim analizama opsežno koristila. 2010. g. izmjerena je izražena struktura u dvodimenzionalnoj funkciji angularnih korelacija za parove čestica kod malih azimutalnih kutnih razlika delta phi i preko širokog raspona razlika pseudorapiditeta delta eta. Ta je struktura nazvana &#39;&#39;greben&#39;&#39;, a promatrana je u događajima s velikim multiplicitetom. Korelacija grebena prvi put se vidjela u sudarima teških iona u kojima znamo da se proizvodi kvarkovsko-gluonska plazma (QGP). Nedavno je opažena struktura grebena u pp događajima visokog multipliciteta kod 7 TeV. Greben u  pp događajima visokog multipliciteta potaknuo je spekulacije o formiranju QGP u malim sustavima. Nedavni rezultati ALICE-a o prvom opažanju povećanja stranosti u sudarima protona s velikim multiplicitetom također nam govore da još ne razumijemo mehanizam formiranja QGP. Korištenje metoda razvijenih u PI grupi može pomoći u razumjevanju podrijetla strukture &#39;&#39;grebena&#39;&#39; novom metodom eliminiranja pozadine koju je već uspješno koristila naša grupa.  Sekundarni cilj ovog projekta je demistificirati pojavu iskrenja  GEM detektora  koji se koriste za TPC nadogradnju ALICE detektora na CERN-u. PI je utemeljio GEM laboratorij s čistom sobom koristeći prijašnji  UKF projekt i grupa je već stekla značajno iskustvo s GEM folijama. GEM folije su sastavni dio nadolazeće nadogradnje ALICE detektora, budući da su neophodne za planirane  pp i teškoionske sudare velikog luminoziteta. Ova nadogradnja je također motivirana otvorenim pitanjima u QGP-u, budući da će run velikog luminoziteta rezultirati značajnim povećanjem količine podataka koji se koriste za QGP analize.]]></summary_hr><summary_en><![CDATA[The primary objective of this project is to explore two particle correlations in proton-proton (pp) collisions using event shape variables extensively used by our group in previous analyses. In 2010, a pronounced structure in the two-dimensional angular correlation function was measured for particle pairs at small azimuthal angle differences delta phi and over a wide range of pseudorapidity differences delta eta. This structure was named the “ridge” and is observed in events with sufficiently high multiplicity. The ridge correlation was first seen in those heavy ion collisions for which we firmly believe that quark-gluon plasma (QGP) is produced.Recently, the ridge correlation was also observed in high-multiplicity pp events at 7 TeV. The appearance of this “ridge-like” structure in high-multiplicity pp events caused speculation for the formation of QGP in small systems. Recent ALICE results of the first observation of strangeness enhancement in high-multiplicity pp collisions are also telling us that we do not yet understand the mechanism of QGP formation. Using the methods developed in the PI’s group may help understand the origin of “ridge-like” structures by a novel background elimination method which was already successfully used by our group. The secondary objective of this project is to demystify the occurrence of sparking in Gas Electron Multiplier (GEM) detectors that are used for TPC upgrade of the ALICE detector at CERN. The PI has founded a GEM Lab with a clean room using a previous Unity through Knowledge Fund grant and the group has already gained significant experience with GEM foils. The GEM foils are an integral part of the upcoming ALICE detector upgrade, since they are essential for the planned high luminosity pp and heavy ion collisions at the LHC. This upgrade is also motivated by the open questions in QGP, since a high luminosity run will result in a significant increase in the data sample used for QGP analyses. ]]></summary_en></project><project>
<id>7618</id><title_hr><![CDATA[Željeznodobni ženski identiteti u južnom dijelu Karpatske kotline]]></title_hr><title_en><![CDATA[]]></title_en><user_id>3432</user_id><user_firstLast_name>Hrvoje Potrebica</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-01</proposal_call><code>DOK-2018-01-7084</code><acronim><![CDATA[FEMINE]]></acronim><duration>01.10.2018 - 29.06.2024</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Humanističke znanosti</scie_area_hr><scie_area_en>Humanities</scie_area_en><scie_field_hr>Arheologija, </scie_field_hr><scie_field_en>Archeology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Filozofski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Humanities and Social Sciences]]></institution_en><team_members_id>25275</team_members_id><team_members_names><![CDATA[ Doktorand: Julia Katarina Kramberger ]]></team_members_names><keywords_hr><![CDATA[željezno doba, žene, identitet, Karpatska kotlina, nošnja, nakit, grobovi, groblja, rod, funkcionalna analiza, bioarheologija]]></keywords_hr><keywords_en><![CDATA[Iron Age, females, identity, Carpathian Basin, costume, jewellery, graves, cemeteries, gender, functional analysis, bioarchaeology]]></keywords_en><summary_hr><![CDATA[Cilj predloženoga projekta o razdoblju željeznoga doba, poduzetoga od strane arheologije u suradnji s antropološkim i arheometalurškim istraživanjima, naglasak stavlja na proučavanje različitih aspekata željeznodobnih (ŽD) ženskih društvenih identiteta koji se jedino mogu rekonstruirati iz arheoloških podataka. U projektu je predviđeno istraživanje zajedničkih modela, uz korištenje trenutnih interdisciplinarnih mogućnosti, koji se odnose na proučavanje rodnoga koncepta, što će predstavljati inovativnu aktivnost i značajan napredak u istraživanju ŽD zajednica u južnom dijelu Karpatske kotline (KK). Ženski identitet sastavljen je od višestrukih značajki koje su združene kako bi stvorile individualnu osobnost. Za vrijeme života pojedinac ima različite društvene identitete, čak i po nekoliko u isto vrijeme. Žene za vrijeme ŽD u južnom dijelu KK postaju posebno vidljive na osnovi arheoloških nalaza koji pokazuju razvoj brojnih karakterističnih predmeta. Naše trenutne spoznaje o položaju i ulozi žena većinom potječu iz istraživanja groblja koja nude prilično točnu sliku o svakodnevnom životu ŽD zajednica. Za vrijeme ŽD u KK uobičajeno je kako su pokojnice bile pokopane u svakodnevnoj nošnji i s osobnim nakitom koji se, s nalazima pršljena, smatraju kao iznimno jasan rodni prikaz. Projekt predstavlja kompleksnu studiju poznatih ŽD ženskih pokopa sa šest groblja u promatranom području na osnovi roda, dobi i grobnih priloga koje mogu obogatiti naše spoznaje o ŽD društvu na mnogo načina, pri čemu se posebna pažnja posvećuje funkcionalnoj analizi kombinacija u grobovima koje prikazuju različite lokalne ŽD zajednice te  višestruke identiteta jedne osobe. Funkcionalna analiza, odnosno kako su različiti elementi nošnje i nakita organizirani i udruženi u različite kombinacije, pruža pouzdane podatke o načinima koje su različiti pojedinci i/ili zajednice odabirali kako bi vizualno prikazali vlastite identitete i društvene odnose.]]></summary_hr><summary_en><![CDATA[Aim of proposed Iron Age project, conducted by archaeology in collaboration with anthropological and archaeometallurgical researches, is emphasis placed on the study of different aspects of the Iron Age (IA) female social identities which only can be reconstructed from the archaeological records. In this project is planning to explore common models, with the use of current interdisciplinary possibilities, in the field of gender concept which will be innovative activity and significant improvements in exploring of IA communities in the southern Carpathian Basin (CB). Female identity is composed of multiple features that are connected together to create an individual personhood. During a lifetime an individual has various social identities, even several at the same time. Females during the IA in the southern CB become increasingly visible in the archaeological record through the development of numerous characteristic accessories. Our present knowledge about position and role of women comes mostly from cemeteries which offer a fairly accurate picture of the everyday life of the IA communities. During the IA in the CB was a standard for the deceased to be buried in the everyday costume and with personal jewellery which, with spindle whorls, are remarkably sharp gender outfits. A project represent a complex study of the known IA female burials from six cemeteries in define region in terms of gender, age and grave goods which can enrich our knowledge of the IA society in many ways, with special attention to the functional analysis of the grave assemblages which reflects different local IA communities and shared identities of single persons. Functional analysis, the manner in which different costume and jewellery elements are composed and associated in various assemblages, provides relevant information regarding the ways in which various individuals and/or different communities chose to visually express their identities and social relationships.]]></summary_en></project><project>
<id>7622</id><title_hr><![CDATA[METALOSUPRAMOLEKULSKE STRUKTURE I ANORGANSKO-ORGANSKI POLIOKSOMETALATNI HIBRIDI ]]></title_hr><title_en><![CDATA[]]></title_en><user_id>134</user_id><user_firstLast_name>Višnja Vrdoljak</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-01</proposal_call><code>DOK-2018-01-2201</code><acronim><![CDATA[MOLART]]></acronim><duration>10.10.2018 - 31.12.2022</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Kemija, </scie_field_hr><scie_field_en>Chemistry, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>25322</team_members_id><team_members_names><![CDATA[ Doktorand: Mirna Mandarić ]]></team_members_names><keywords_hr><![CDATA[metalosupramolekulski spojevi, polioksometalati, hibridi, hidrazoni, dikarboksilati, struktura, biološka svojstva, kvantno kemijski računi]]></keywords_hr><keywords_en><![CDATA[metallosupramolecular compounds, poyoxometalates, hybrides, hydrazones, dicarboxylate, structure, biological properties, quantum chemical calculations]]></keywords_en><summary_hr><![CDATA[Glavna ideja projekta temelji se na principima koordinacijske kemije u dizajnu i sintezi novih MoVI metalosupramolekulskih struktura i organsko-anorganskih hibridnih polioksometalatnih materijala. Sinteza novih spojeva bazirat će se na “bottom-up” pristupu, odnosno njihovoj pripravi iz građevnih blokova nastalih in situ kako u otopini tako i u čvrstom stanju. To će omogućiti ispitivanje procesa samoudruživanja i kristalnog rasta navedenih sustava. Poveznica svih segmenata istraživanja je i u pronalaženju uvjeta neophodnih u kontroli sastava, strukture i svojstava ciljnih spojeva. Očekuje se da će ovo istraživanje dati uvid u mehanizme ispitivanih reakcija i omogućiti tumačenje utjecaja različitih inter- i intramolekulskih interakcija na svojstva višedimenzionalnih sustava ili njihovih građevnih blokova. Metode koje će se koristiti u sintezi organskih, metalosupramolekulskih i anorgansko-organskih polioksometalatnih hibrida bit će modificirane metode otopinske kemije, ali će se koristiti i metodologije zelene kemije. Istraživanja termički induciranih reakcija u čvrstom stanju predstavljaju dodatni izazov ovoga projekta. Predloženi projekt sastoji se od sljedećih dijelova: (i) dizajna i sinteze multifunkcionalnih N,O-donorskih liganada i ispitivanja njihovih svojstava; (ii) sinteze novih MoVI metalosupramolekulskih sustava; (iii) sinteze novih hibridnih organsko-anorganskih polioksometalatnih spojeva; (iv) karakterizacije svih priređenih spojeva; (v) kvantno-kemijskih proračuna i teorijskih tumačenja eksperimentalnih rezultata s ciljem boljeg razumijevanja i poboljšanja ispitivanih procesa; (vi) ispitivanja kemijskih i fizikalnih svojstava priređenih spojeva; (vii) ispitivanja bioloških svojstava odabranih spojeva.]]></summary_hr><summary_en><![CDATA[The main idea of the project is to apply principles of coordination chemistry to design and synthesise new MoVI metallosupramolecular architectures and POM-based organic-inorganic hybrid materials. Such systems will be developed via a bottom-up approach combining suitable building blocks generated in situ in solution as well as in the solid state. The complexity in their construction is an invaluable opportunity to study the self-assembly and crystal growth processes. Links between all segments of this research are in finding suitable conditions that are necessary to control the composition and/or structural features of target architectures. It is expected that our investigation will give insight into particular reaction mechanisms and provide explanation for the influence of different inter- and intramolecular interactions on properties of high-dimensional compounds or their building blocks. Methods used in the synthesis of organic, metallosupramolecular and inorganic-organic hybrids will be modified and performed in accordance to conventional, but also green, chemical methodologies. Investigations of thermally induced reactions in the solid state are additional challenging part of the project. The proposed project consists of the following parts: (i) design and synthesis of multifunctional N,O-donor ligands and study of their properties; (ii) synthesis of novel MoVI metallosupramolecular architectures; (iii) preparation of novel hybrid organic-inorganic compounds based on polyoxomolybdates; (iv) characterisation of all prepared compounds; (v) quantum chemical calculations and theoretical support to the experimental research which will be used to understand and guide the improved efficiency of the studied processes; (vi) investigation of chemical and physical properties of prepared compounds; (vii) investigation of biological properties of selected compounds.]]></summary_en></project><project>
<id>7625</id><title_hr><![CDATA[H2020 “Mediterranean Aquaculture Integrated Development – MedAID”]]></title_hr><title_en><![CDATA[]]></title_en><user_id>2574</user_id><user_firstLast_name>Snježana Zrnčić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-01</proposal_call><code>DOK-2018-01-2908</code><acronim><![CDATA[]]></acronim><duration>28.09.2018 - 31.12.2022</duration><status>Završio</status><financ_value></financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Veterinarska medicina, </scie_field_hr><scie_field_en>Veterinary medicine, </scie_field_en><institution_hr><![CDATA[Hrvatski veterinarski institut]]></institution_hr><institution_en><![CDATA[Croatian Veterinary Institute]]></institution_en><team_members_id>25383</team_members_id><team_members_names><![CDATA[ Doktorand: Ivana Giovanna Zupičić ]]></team_members_names><keywords_hr><![CDATA[]]></keywords_hr><keywords_en><![CDATA[]]></keywords_en><summary_hr><![CDATA[]]></summary_hr><summary_en><![CDATA[]]></summary_en></project><project>
<id>7628</id><title_hr><![CDATA[Normativni modeli vaskularnih biomarkera za unapređenje stratifikacije kardiovaskularnog rizika u primarnoj i sekundarnoj prevenciji]]></title_hr><title_en><![CDATA[Normative models of,vascular biomarkers for improvement of stratification of cardiovascular risk in primary and secondary prevention]]></title_en><user_id>2713</user_id><user_firstLast_name>Ana Jerončić</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2018-01</proposal_call><code>IP-2018-01-4729</code><acronim><![CDATA[NormPreven]]></acronim><duration>12.11.2018 - 11.02.2024</duration><status>Prekinut</status><financ_value>121.640,45 eur</financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Javno zdravstvo i zdravstvena zaštita, Kliničke medicinske znanosti, Dentalna medicina, </scie_field_hr><scie_field_en>Public health and health services, Clinical sciences, Dental medicine, </scie_field_en><institution_hr><![CDATA[Sveučilište u Splitu, Medicinski fakultet]]></institution_hr><institution_en><![CDATA[University of Split School of Medicine]]></institution_en><team_members_id>65, 3182, 4547, 2679, 24041, 24088, 24104, 24136, 19211, 24198, 22661, 5404, 24221, 4096, 865290, </team_members_id><team_members_names><![CDATA[Joško Božić, Viktor Čulić, Renata Pecotić, Mladen Boban, Daniela  Šupe-Domić, Roko Duplančić, Maja Vajagić, Mario Podrug , Tea Galić, Damir Ivanković, Marija Roguljić, Tina Poklepović Peričić, Darko Božić, Varja Đogaš, Pjero Koren, ]]></team_members_names><keywords_hr><![CDATA[kardiovaskularni rizik, primarna i sekundarna prevencija, vaskularni biomarkeri, unapređenje procjene rizika, inovativni modeli   ]]></keywords_hr><keywords_en><![CDATA[cardiovascular risk, primary and secondary prevention, vascular biomarkers,  improvement in risk assessment, innovative models]]></keywords_en><summary_hr><![CDATA[Hrvatska ima visok mortalitet od kardiovaskularnih bolesti i stopu izbježive smrtnosti. Točna procjena ukupnog kardiovaskularnog (KV) rizika omogućuje rano otkrivanje osoba s rizikom i izbor optimalne preventivne skrbi. Tradicionalni modeli procjene KV rizika predviđaju rizik na razini populacije, ali nisu dovoljno točni u utvrđivanju rizika za pojedinca. Vaskularni biomarkeri (VB), pokazatelji ranog vaskularnog starenja, imaju velik potencijal za preciznije predviđanje pojedinačnog rizika.Projekt predviđa razvoj dva inovativna modela za procjenu KV rizika temeljena na VB, kao nadopunu tradicionalnim pristupima. Slučajno ćemo uzorkovati populaciju odraslih zdravstvenih osiguranika u Splitu i sakupiti njihove podatke o čimbenicima KV rizika, VB i drugim stanjima povezanim s vaskularnim oštećenjem, kao što su parodontitis, opstruktivna apneja u spavanju te kardiometabolički rizik. Model1 temelji se na robusnom grupiranju ispitanika s obzirom na različite VB što smo već opazili u velikoj kohortnoj studiji na populaciji Splita i što ukazuje na zajedničku vaskularnu strukturu unutar skupine. Testirat ćemo: a) replicira li se fenomen u našem uzorku, b) odražava li grupiranje stupanj vaskularne štete; c) je li u korelaciji s tradicionalnim modelom KV rizika. Model2 obuhvaća izradu normativnih jednadžbi centralnog augmentacijskog indeksa - surogatne mjere arterijske elastičnosti, na ispitanicima s niskim KV rizikom uz korištenje regresijskih modela specifičnih za spol i dobnu dekadu te uz dodatni prediktor što bi trebao poboljšati preciznost stratifikacije KV rizika. Modeli će se procjenjivati neizravno, putem slaganja sa SCORE modelom te procjenom njihove povezanosti s brojnim pokazateljima vaskularnog oštećenja. Provest će se i mnoštvo epidemioloških istraživanja.Očekujemo da ćemo izraditi obećavajuće modele za unapređenje procjene KV rizika, unaprijediti  znanje o epidemiologiji ispitivanih stanja i dati doprinos javno-zdravstvenim intervencijama utemeljenim na dokazima.]]></summary_hr><summary_en><![CDATA[Croatia is country with high burden of cardiovascular diseases, and amenable mortality. An accurate assessment of total cardiovascular (CV) risk enables early detection of people at risk and choice of optimal preventive treatment. Conventional models of CV risk assessment predict population attributable risk but lack sensitivity or specificity in identifying individual’s risk. Vascular biomarkers such as arterial stiffness indices are hallmarks of early vascular aging and have potential to predict this risk more accurately.We propose two innovative models for CV risk assessment that are based on vascular biomarkers and intended to complement traditional approaches. We will randomly sample adult primary care population from Split and collect data on CV risk factors, vascular biomarkers, and other conditions associated with vascular damage such as periodontitis and obstructive sleep apnea diagnoses, cardiometabolic risk. Model 1 is based on robust clustering of subjects according to various vascular biomarkers we had observed in large cohort; implying common vascular structure in a cluster. We will test if: a) phenomenon is replicated in our sample, b) clustering reflects the gradation of vascular damage; c) is correlated to traditional CV risk stratification model (SCORE). Model 2 foresees building of normative equations of central augmentation index, a surrogate measure of arterial stiffness, on data of low CV risk participants by using sex- and age-decade specific regression models and additional predictor which should improve precision of CV risk stratification. Models will be assessed indirectly via agreement with the SCORE model; and by evaluating their associations with numerous indicators of vascular damage. A multitude epidemiological research will also be performed.We expect to generate promising models for CV risk assessment, improve existing knowledge on epidemiology of screened conditions, and provide input for evidence-based public health interventions.]]></summary_en></project><project>
<id>7629</id><title_hr><![CDATA[Lipidi hrane, spol i dob u patogenezi metaboličkog sindroma]]></title_hr><title_en><![CDATA[]]></title_en><user_id>12663</user_id><user_firstLast_name>Kristina Starčević</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>DOK</proposal_type><proposal_call>2018-01</proposal_call><code>DOK-2018-01-6623</code><acronim><![CDATA[DietMetSyn]]></acronim><duration>03.09.2018 - 20.03.2024</duration><status>U tijeku</status><financ_value></financ_value><scie_area_hr>Biomedicina i zdravstvo</scie_area_hr><scie_area_en>Biomedicine and health sciences</scie_area_en><scie_field_hr>Veterinarska medicina, </scie_field_hr><scie_field_en>Veterinary medicine, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Veterinarski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Veterinary Medicine]]></institution_en><team_members_id>25364</team_members_id><team_members_names><![CDATA[ Doktorand: Petra Roškarić ]]></team_members_names><keywords_hr><![CDATA[Lipidi, metabolički sindrom, hrana, miRNA, kronična upala, rezistencija na inzulin]]></keywords_hr><keywords_en><![CDATA[Lipids, metabolic syndrome, food, miRNA, cronic inflammation, insulin resistence]]></keywords_en><summary_hr><![CDATA[Poremećaj metabolizma lipida ključna je komponenta u razvoju metaboličkog sindroma pa je i prevalencija metaboličkog sindroma povezana sa stupnjem pretilosti. Stoga, promjene u sastavu hrane mogu biti važna strategija za prevenciju metaboličkog sindroma i posljedičnih bolesti.Pretilost nastaje tijekom dugotrajne pozitivne energetske ravnoteže koja potiče proupalni odgovor. To uzrokuje kroničnu upalu i pojačani dotok lipida iz masnog tkiva u jetru, mišićno tkivo i gušteraču što rezultira s glukotoksičnosti i lipotoksičnosti. Kronična upala i rezistencija na inzulin danas su prepoznati kao bitni čimbenici kod mnogih bolesti kao što su dijabetes tipa 2, kardiovaskularne bolesti, Alzheimerove bolesti i tumora.Za postizanje ciljeva projekta istražit ćemo nekoliko interakcija važnih za patogenezu metaboličkog sindroma: A) utjecaj n3/n6 omjera lipida hrane i dodavanja DHA kao prevencije metaboličkog sindroma, B) utjecaj n3/n6 omjera lipida hrane i dodavanja DHA kao moguće terapije metaboličkog sindroma, C) prijenos sklonosti razvitku metaboličkog sindroma i prekomjerne tjelesne mase s roditelja na potomstvo kao i utjecaj prehrane potomstva na težinu poremetnji prije i nakon spolne zrelosti, D) interakciju između dobi i metaboličkog sindroma i E) metabolizam lipida u tumorskom tkivu i tumorske markere lipidnog porijekla kao moguću vezu između pretilosti, metaboličkog sindroma, kronične upale i tumora.Naposlijetku, podaci iz cijelog projekta rezultirat će integracijom stečenih znanja iz svih pokusa i boljem razumijevanju složenosti patogeneze metaboličkog sindroma. Integrativni pristup omogućit će nove pristupe prevenciji i liječenju metaboličkog sindroma putem modifikacije prehrane kao i bolje razumijevanje veze između kronične upale izazvane pretilošću i tumora.]]></summary_hr><summary_en><![CDATA[Dysfunction of lipid metabolism is a key component in the development of metabolic syndrome and the prevalence of metabolic syndrome is strongly associated with the severity of obesity. Therefore, dietary intervention could be important strategy for the prevention of metabolic syndrome and associated diseases.Obesity arises from a sustained positive energy balance which triggers a pro-inflammatory response. These disturbances culminate in impaired insulin signaling, dysregulated glucose homeostasis and consequent development of insulin resistance. Chronic inflammation and insulin resistance are now recognized as contributing factors to many modern diseases such as insulin non dependent diabetes mellitus, cardiovascular diseases, Alzheimer disease and cancer. To achieve project objectives we will investigate several interactions that take place in metabolic syndrome pathogenesis: A) Influence of dietary n6/n3 ratio and DHA as a preventive mechanism on the severity of metabolic syndrome, B) Influence of dietary n6/n3 ratio and DHA on therapy of induced metabolic syndrome, C) Parental transmission of predisposition to obesity-related disorders to their offspring and influence of offspring diet on severity of metabolic disorders before and after sexual maturity, D) Interaction between age and metabolic syndrome and E) Cancer lipid metabolism and cancer markers of lipid origin as well as possible link between obesity, metabolic syndrome, low grade chronic inflammation and cancer.Finally, data from the whole project will result in the integration of gained knowledge from all experiments and in better understanding of complex pathogenesis of metabolic syndrome. Integrative approach will allow us to suggest new approaches to dietary prevention and therapy of metabolic syndrome and to better understand underlying link between obesity related chronic inflammation and cancer.]]></summary_en></project><project>
<id>7631</id><title_hr><![CDATA[Razvoj i toplinska svojstava inteligentne odjeće]]></title_hr><title_en><![CDATA[Development and thermal properties of intelligent clothing]]></title_en><user_id>3850</user_id><user_firstLast_name>Dubravko Rogale</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2018-01</proposal_call><code>IP-2018-01-6363</code><acronim><![CDATA[ThermIC]]></acronim><duration>01.01.2019 - 31.05.2023</duration><status>Završio</status><financ_value>109.907,76 eur</financ_value><scie_area_hr>Tehničke znanosti</scie_area_hr><scie_area_en>Technological sciences</scie_area_en><scie_field_hr>Tekstilna tehnologija, Temeljne tehničke znanosti, </scie_field_hr><scie_field_en>Textile technology, Basic engineering sciences, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Tekstilno-tehnološki fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Textile Technology]]></institution_en><team_members_id>5611, 5992, 6964, 4448, 4273, 24165, 857, 3644, 26338, </team_members_id><team_members_names><![CDATA[Snježana  Firšt Rogale, Željko Knezić, Antoneta Tomljenović, Martina  Bobovčan Marcelić, Siniša Fajt, NIKOLINA JUKL, Kristina Krulić Himmelreich, Emilija Zdraveva, Daniel  Časar Veličan, ]]></team_members_names><keywords_hr><![CDATA[inteligentna odjeća, toplinska svojstva, termalni maneken,  vruća ploča, toplinski konduktometar, visokotehnološke metode spajanja odjeće]]></keywords_hr><keywords_en><![CDATA[intelligent clothing, thermal properties, thermal mannequin, hot plate, heat conductor, high-tech joining methods of clothing]]></keywords_en><summary_hr><![CDATA[Tim znanstvenika na Tekstilno-tehnološkom fakultetu bavi se razvojem potpuno nove vrste odjeće nazvane inteligentna odjeća s adaptivnim termoizolacijskim svojstvima. Razvili su i patentirali dvije generacije funkcionirajućih prototipova gdje senzori prate stanje vanjskog okoliša i mikroklime inteligentne odjeće, kao i trenutačno stanje tehničkih podsustava u odjeći. Stanje interpretira ugrađeno računalo, donosi zaključke o njemu te donosi odluke o potrebnim promjenama kako bi odjevni predmet smisleno reagirao i automatski adaptirao svoja toplinska svojstva u skladu sa stanjem okoliša i fizičke aktivnosti nositelja. Početna istraživanja i razvoj ukazala su na opravdanost uvođenja koncepcije inteligentne odjeće, a prototipovi i dijelovi mjeriteljske opreme dobili su priznanje međunarodne inovacijske zajednice nizom nagrada.Ciljevi ovog projekta su usavršavanje gradbene arhitekture sustava senzor-računalo-aktuator, izrada novih ergonomski oblikovanih segmentiranih termoizolacijskih komora i tehničkih podsustava korištenjem visokotehnoloških metoda spajanja te uspostava prototipa nove generacije inteligentne odjeće.Potom će se istražiti rad i karakteristike tehničkih podsustava i uspješnosti reakcija inteligentne odjeće s adaptivnim toplinskim svojstvima.  Za to će biti potrebno uspostaviti više novih mjernih metoda i protokola za mjerenje toplinskih svojstava te uspostaviti istraživački laboratorij za cjelovita mjerenja toplinskih svojstava odjeće. Stoga će se izvesti integracija svih mjeriteljskih podsustava u novoj klima komori podesivih parametara. Na temelju tih istraživanja izvest će se završno optimiranje reakcija inteligentne odjeće i određivanje njezinih svojstava pri promjenjivim uvjetima okoliša u laboratorijskim uvjetima i pri fizičkoj aktivnosti nositelja.Konačan cilj projekta je izrada usavršenog prototipa i istraživanje karakteristika nove vrste inteligentne odjeće te uspostava laboratorija za ispitivanje toplinskih svojstava svih vrsta odjeće.]]></summary_hr><summary_en><![CDATA[A team of scientists of the Faculty of Textile Technology is dealing with the development of an intelligent clothing with adaptive thermal insulation properties. They have developed and patented two generations of prototypes where sensors monitor the state of outdoor environment and the microclimate of intelligent clothing. The integrated computer interprets the existing situation, and it makes decisions about necessary changes so that the article of clothing intelligently responds and automatically adapts its thermal properties in accordance with the environment and physical activities of the wearer. Initial research activities and development have shown the justification of introducing the concept of intelligent clothing, while prototypes and parts of metrology equipment have been recognized by the innovation community with awards. The objectives of this project are to improve the architecture of the sensor-computer-actuator system, to design new ergonomically shaped segmented thermal insulation chambers and technical subsystems using high-tech welding methods and to create a new generation of intelligent clothing prototypes. The operation and characteristics of the technical subsystems and the reaction rate of intelligent clothing will be investigated. A new research laboratory for complete measurements of thermal properties of clothing shall also be established. The integration of metrology subsystems will be performed in the new climatic chamber. On the basis of these research activities, the final optimization of the reactions of intelligent clothing will be performed, and its properties in changing environmental conditions under laboratory conditions and during physical activities of the wearer will be determined. The final objective of this project is to create a sophisticated prototype and to study the properties of new kind of intelligent clothing and to establish a new laboratory for testing thermal properties of all types of clothing.]]></summary_en></project><project>
<id>7633</id><title_hr><![CDATA[Implicitna ličnost, donošenje odluka i vođenje u organizacijama]]></title_hr><title_en><![CDATA[Implicit personality, decision making and organizational leadership]]></title_en><user_id>3974</user_id><user_firstLast_name>Zvonimir Galic</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2018-01</proposal_call><code>IP-2018-01-9354</code><acronim><![CDATA[IMPEDEMOL]]></acronim><duration>01.12.2018 - 30.04.2023</duration><status>Završio</status><financ_value>79.208,97 eur</financ_value><scie_area_hr>Društvene znanosti</scie_area_hr><scie_area_en>Social sciences</scie_area_en><scie_field_hr>Psihologija, </scie_field_hr><scie_field_en>Psychology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Filozofski fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Humanities and Social Sciences]]></institution_en><team_members_id>23666, 6601, 22773, 5480, 13589, 4979, 6848, 5575, 27640, </team_members_id><team_members_names><![CDATA[Nikola Erceg, Maja Parmač Kovačić, Mitja Ružojčić, Andreja Bubić, Maja Klindžić, Nataša Trojak, Željko Jerneić, Tomislav Hernaus, Antun Palanović, ]]></team_members_names><keywords_hr><![CDATA[vođenje u organizacijama, implicitna ličnosti, motiv za moći, testovi uvjetovanog rezoniranja,  individualne razlike u donošenju odluka]]></keywords_hr><keywords_en><![CDATA[organizational leadership, implicit personality, power motive, conditional reasoning tests,  individual differences in decision-making]]></keywords_en><summary_hr><![CDATA[Menadžeri i rukovoditelji u organizacijama odgovorni su za motiviranje zaposlenika, donošenje kvalitetnih odluka i izgradnju timova koji će s vremenom postizati dobre rezultate. Oni su ključni za uspjeh i razvoj tvrtki, kao i za motivaciju i dobrobit podređenih. Ipak, istraživanja pokazuju da je više od pola menadžera neuspješno u svom poslu te ili sami daju otkaz ili bivaju otpušteni. Također, neke studije ukazuju na to da čak 50% odluka koje donesu visokopozicionirani menadžeri rezultiraju neuspjehom. Neovisno o sektoru ili poziciji unutar organizacijske hijerarhije, razlozi za neuspjeh menadžera uglavnom su povezani s nekim njihovim psihološkim karakteristikama.Smatramo da rukovoditelji utječu na organizacijske ishode putem skupa kompetencija koje čine njihov rukovoditeljski potencijal. Rukovoditeljski potencijal dijelom ovisi o ličnosti i kompetentnosti u  donošenju odluka. Kroz ovaj projekt, pokušat ćemo istražiti mogu li novije spoznaje u području mjerenja implicitne ličnosti doprinijeti istraživanju rukovođenja u organizacijama. Također, u skladu s novijim prijedlozima o potrebi integracije spoznaja iz područja psihologije rada i organizacijske psihologije s onima iz područja prosuđivanja i donošenja odluka, istražit ćemo kako je uspješnost u rukovođenju povezana s individualnim razlikama u odlučivanju.Kao ishod ovog projekta, planiramo razviti i empirijski validirati bateriju psihologijskih testova za odabir i razvoj menadžera, koja će biti bazirana na najnovijim znanstvenim spoznajama u području selekcije i menadžmenta. Baterija će se sastojati od testova implicitne ličnosti temeljenih na paradigmi uvjetovanog rezoniranja, instrumenata za mjerenje individualnih razlika u donošenju odluka i testa situacijskih prosudi za procjenu rukovoditeljskog potencijala.]]></summary_hr><summary_en><![CDATA[Managers or organizational leaders are responsible for motivating their employees, making good decisions, and building teams that produce results over time. They are crucial for success and development of companies as well as for motivation and well-being of their subordinates. Still, recent research shows that about half of managers are unsuccessful in their jobs and either resign or get fired. Moreover, some studies showed that important decisions by top managers in at least 50% of cases result with failure.  Irrespective of the type of industry or exact level of the position in an organizational hierarchy, the reasons for managerial derailment are typically related to some psychological characteristics of the leaders.We believe that leaders affect organizations through a set of competencies that make their leadership potential, and that, in turn, determine their performance.  The leadership potential and leadership performance are to a large extent a function of leaders’ personality, and decision-making competencies. Within the project, we will try to explore how recent advances in implicit personality assessment could contribute to organizational leadership research. Moreover, in accordance with recent calls to integrate work and organizational psychology with decision-making literature, we will try to explore how is leadership performance related to individual differences in decision-making. As an outcome of this research project, we plan to develop and empirically test a battery of psychological instruments for selection and development of managers that is based on recent advances in personnel selection and management literature. The battery will consist of the tests of implicit personality based on the conditional reasoning paradigm, instruments for measurement of individual differences in decision-making and a situational judgment test for the assessment of leadership potential.]]></summary_en></project><project>
<id>7634</id><title_hr><![CDATA[Asimptotička analiza rubnih problema u mehanici kontinuuma]]></title_hr><title_en><![CDATA[Asymptotic analysis of boundary value problems in continuum mechanics]]></title_en><user_id>1462</user_id><user_firstLast_name>Eduard Marušić-Paloka</user_firstLast_name><svouser_id></svouser_id><svouser_firstLast_name> </svouser_firstLast_name><proposal_type>IP</proposal_type><proposal_call>2018-01</proposal_call><code>IP-2018-01-2735</code><acronim><![CDATA[ASAN]]></acronim><duration>01.10.2018 - 30.09.2022</duration><status>Završio</status><financ_value>94.498,64 eur</financ_value><scie_area_hr>Prirodne znanosti</scie_area_hr><scie_area_en>Natural sciences</scie_area_en><scie_field_hr>Matematika, Fizika, Biologija, </scie_field_hr><scie_field_en>Mathematics, Physics, Biology, </scie_field_en><institution_hr><![CDATA[Sveučilište u Zagrebu, Prirodoslovno-matematički fakultet]]></institution_hr><institution_en><![CDATA[University of Zagreb, Faculty of Science]]></institution_en><team_members_id>4816, 22664, 23314, 817, 3424, 864969, </team_members_id><team_members_names><![CDATA[Josip Tambača, Marko Radulović, Matko Ljulj, Igor Pažanin, Andrijana Ćurković, Jean Carlos Nakasato, ]]></team_members_names><keywords_hr><![CDATA[asimptotička analiza, mehanika kontinuuma, rubni problemi, parcijalne diferencijalne jednadžbe, matematičko modeliranje]]></keywords_hr><keywords_en><![CDATA[asymptotic analysis, continuum mechanics, boundary value problems, partial-differential equations, mathemetical modeling]]></keywords_en><summary_hr><![CDATA[Cilj ovog projekta je koristiti asimptotičke metode za izvod efektivnih modela koji opisuju razne procese u mehanici kontinuuma. Istraživanje je podijeljeno u 7 cjelina koje su opisane sljedećim ciljevima: Cilj 1. Perturbacija ruba i Darcy-Weisbachov zakon. Koristeći perturbacijske tehnike razvijene u [24] i [25] izvodimo formulu za računanje pada tlaka u cijevi, usljed trenja o stijenku. Cilj 2. Spoj tankih sudova ispunjenih fluidom. Uobičajena metoda za proučavanje tokova fluida kroz takva područja je izvođenje nižedimenzionalnih modela. Planiramo koristiti sličan pristup kakav je korišten u teoriji elastičnosti za izvođenje novih modela u mehanici fluida. Cilj 3. Nestacionarni tok mikropolarnog fluida. Idući cilj predložiti je nove efektivne modele višeg reda točnosti koji bi opisivali nestacionarni tok mikropolarnog fluida u tankim cijevima.Cilj 4. Neizotermni tok u poroznoj sredini. Motivirani brojnim inženjerskim primjenama, planiramo izučavati i prijenos topline u fluidu koji se kreće kroz poroznu sredinu. Cilj 5. Modeli interakcije elastičnih tijela. U ovom dijelu projekta radit ćemo na izvodu i opravdanju različitih modela interakcije elastičnih tijela različitih veličina. Cillj 6. Interakcija elastične ploče i tankog sloja kompresibilnog fluida.Ideja je razviti pojednostavljeni model za interakciju tankog sloja fluida i ploče koja se nalazi na dijelu ruba domene.]]></summary_hr><summary_en><![CDATA[We propose a research that uses rigorous asymptotic techniques for deriving effective models governing different processes in continuum mechanics. The research is separated in 6 parts defined by following goals: Goal 1. Boundary perturbation and the Darcy-Weisbach law.  Using the perturbation and homogenization methods developed , our first goal is to derive the effective law describing the pressure drop in the rough pipe, due to the friction on the boundary. Goal 2. Junctions of thin vessels filled with fluid.  We plan to use the methods applied in elasticity theory and hope to derive some new models. Goal 3. Non-stationary micropolar fluid flow. Our next goal is to propose new effective models of higher order of accuracy describing non-stationary flow of a micropolar fluid in thin pipe-like domains. Goal 4. Non-isothermal porous medium flow. Motivated by a broad range of engineering applications, we also intend to study heat transfer phenomena through fluid- saturated porous media. Goal 5. Interactions of elastic bodies. We will work on derivation and justification of  different models of interaction of elastic bodies of different sizes. For instance three-dimensional and thin plate-like elastic bodies or thin plate-like and thin rod-like elastic bodies. Goal 6.Interaction of an elastic plate and a thin layer of compressible fluid. The idea is to develop a simplified model for the interaction of the thin layer of fluid and the plate which is part of the fluid domain boundary.  ]]></summary_en></